I Pirko

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Contrasting roles for CD4 vs. CD8 T-cells in a murine model of virally induced "T1 black hole" formation
    Istvan Pirko
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 7:e31459. 2012
  2. pmc Preserved vascular integrity and enhanced survival following neuropilin-1 inhibition in a mouse model of CD8 T cell-initiated CNS vascular permeability
    Georgette L Suidan
    Neuroscience Graduate Program, University of Cincinnati, Cincinnati, OH 45267, USA
    J Neuroinflammation 9:218. 2012
  3. pmc A hematopoietic contribution to microhemorrhage formation during antiviral CD8 T cell-initiated blood-brain barrier disruption
    Holly L Johnson
    Department of Neurology, Mayo Clinic, Rochester, MN, USA
    J Neuroinflammation 9:60. 2012
  4. pmc Advances in understanding gray matter pathology in multiple sclerosis: Are we ready to redefine disease pathogenesis?
    Robert Zivadinov
    Buffalo Neuroimaging Analysis Center, University at Buffalo, Buffalo, NY, USA
    BMC Neurol 12:9. 2012
  5. pmc CMV infection attenuates the disease course in a murine model of multiple sclerosis
    Istvan Pirko
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 7:e32767. 2012
  6. pmc Iron deposition and inflammation in multiple sclerosis. Which one comes first?
    Robert Zivadinov
    Buffalo Neuroimaging Analysis Center, University at Buffalo, Buffalo, NY, USA
    BMC Neurosci 12:60. 2011
  7. pmc Brain atrophy correlates with functional outcome in a murine model of multiple sclerosis
    I Pirko
    Mayo Clinic, Department of Neurology, College of Medicine, Rochester, MN 55905, USA
    Neuroimage 54:802-6. 2011
  8. doi request reprint Non-lesional white matter changes in pediatric multiple sclerosis and monophasic demyelinating disorders
    J M Tillema
    Department of Neurology, Mayo Clinic, Minnesota 55905, USA
    Mult Scler 18:1754-9. 2012
  9. pmc Diffusion-weighted imaging characteristics of biopsy-proven demyelinating brain lesions
    N Abou Zeid
    Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Neurology 78:1655-62. 2012
  10. doi request reprint Novel immunomodulatory approaches for the management of multiple sclerosis
    O H Kantarci
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
    Clin Pharmacol Ther 95:32-44. 2014

Collaborators

  • Diana M Lindquist
  • M Rodriguez
  • Kevin D Pavelko
  • J M Tillema
  • C Giannini
  • Robert Zivadinov
  • Georgette L Suidan
  • Holly L Johnson
  • O H Kantarci
  • N Abou Zeid
  • Aaron J Johnson
  • B Scheithauer
  • L Linbo
  • Fang Jin
  • Kim B Seroogy
  • Anne K Lohrey
  • Lisa M Hanson
  • K M Thomsen
  • C F Lucchinetti
  • S D Weigand
  • Yi Chen
  • B Erickson
  • Jonathan W Dickerson
  • Theresa W Chan
  • J E Parisi
  • Jeremiah R McDole
  • Bianca Weinstock-Guttman

Detail Information

Publications11

  1. pmc Contrasting roles for CD4 vs. CD8 T-cells in a murine model of virally induced "T1 black hole" formation
    Istvan Pirko
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 7:e31459. 2012
    ..These findings demonstrate contrasting roles for these cell types, with additional evidence for a direct pathogenic role of CD8 T-cells in our model of T1 black hole formation...
  2. pmc Preserved vascular integrity and enhanced survival following neuropilin-1 inhibition in a mouse model of CD8 T cell-initiated CNS vascular permeability
    Georgette L Suidan
    Neuroscience Graduate Program, University of Cincinnati, Cincinnati, OH 45267, USA
    J Neuroinflammation 9:218. 2012
    ..Our laboratory has developed a murine model of CD8 T cell-initiated central nervous system (CNS) vascular permeability in which vascular endothelial growth factor (VEGF) signaling plays a prominent role in BBB disruption...
  3. pmc A hematopoietic contribution to microhemorrhage formation during antiviral CD8 T cell-initiated blood-brain barrier disruption
    Holly L Johnson
    Department of Neurology, Mayo Clinic, Rochester, MN, USA
    J Neuroinflammation 9:60. 2012
    ..Therefore, we hypothesize that hematopoietic factors contribute to susceptibility to brain hemorrhage, CNS vascular permeability and death following induction of PIFS...
  4. pmc Advances in understanding gray matter pathology in multiple sclerosis: Are we ready to redefine disease pathogenesis?
    Robert Zivadinov
    Buffalo Neuroimaging Analysis Center, University at Buffalo, Buffalo, NY, USA
    BMC Neurol 12:9. 2012
    ..Monitoring the evolution of GM damage is becoming an important marker in predicting future disease course and response to therapy in MS patients...
  5. pmc CMV infection attenuates the disease course in a murine model of multiple sclerosis
    Istvan Pirko
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 7:e32767. 2012
    ..Future studies in this co-infection model will provide insight into mechanisms which modulate the development of demyelination and may be utilized for the development of novel therapeutic strategies...
  6. pmc Iron deposition and inflammation in multiple sclerosis. Which one comes first?
    Robert Zivadinov
    Buffalo Neuroimaging Analysis Center, University at Buffalo, Buffalo, NY, USA
    BMC Neurosci 12:60. 2011
    ..Creating a representative animal model that can study independently such relationship will be the key factor in this endeavor...
  7. pmc Brain atrophy correlates with functional outcome in a murine model of multiple sclerosis
    I Pirko
    Mayo Clinic, Department of Neurology, College of Medicine, Rochester, MN 55905, USA
    Neuroimage 54:802-6. 2011
    ..These studies are expected to pave the way to a better understanding of the substrate of disability in MS models...
  8. doi request reprint Non-lesional white matter changes in pediatric multiple sclerosis and monophasic demyelinating disorders
    J M Tillema
    Department of Neurology, Mayo Clinic, Minnesota 55905, USA
    Mult Scler 18:1754-9. 2012
    ..To analyze diffusion tensor imaging (DTI) derived metrics between patients with childhood onset multiple sclerosis (MS), monophasic demyelinating illnesses, and healthy controls...
  9. pmc Diffusion-weighted imaging characteristics of biopsy-proven demyelinating brain lesions
    N Abou Zeid
    Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Neurology 78:1655-62. 2012
    ....
  10. doi request reprint Novel immunomodulatory approaches for the management of multiple sclerosis
    O H Kantarci
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
    Clin Pharmacol Ther 95:32-44. 2014
    ..In the future, we envision new drugs to enhance remyelination and protect neurons and axons from death in order to promote central nervous system regeneration and repair...
  11. ncbi request reprint Neuroimaging of demyelination and remyelination models
    I Pirko
    Department of Neurology, Waddell Center for Multiple Sclerosis, University of Cincinnati, 260 Stetson St, Suite 2300, Cincinnati, OH 45267 0525, USA
    Curr Top Microbiol Immunol 318:241-66. 2008
    ..High field strength small-animal experimental MRI will continue to evolve and interact with the development of new human MR imaging and experimental NMR techniques...

Research Grants3

  1. CD8+ T cells in formation of T1 black holes in animal model of multiple sclerosis
    Istvan Pirko; Fiscal Year: 2009
    ..Studying our novel animal model will allow us to understand how the immune system mediates the formation of this MRI finding, which may lead to the development of more effective therapies in MS." ..
  2. CD8+ T cells in formation of T1 black holes in animal model of multiple sclerosis
    Istvan Pirko; Fiscal Year: 2010
    ..Studying our novel animal model will allow us to understand how the immune system mediates the formation of this MRI finding, which may lead to the development of more effective therapies in MS." ..
  3. CD8+ T cells in formation of T1 black holes in animal model of multiple sclerosis
    Istvan Pirko; Fiscal Year: 2009
    ..Studying our novel animal model will allow us to understand how the immune system mediates the formation of this MRI finding, which may lead to the development of more effective therapies in MS." ..