G M Petersen

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. ncbi request reprint Genetic testing
    G M Petersen
    Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA
    Hematol Oncol Clin North Am 14:939-52. 2000
  2. ncbi request reprint Pancreatic cancer genetic epidemiology consortium
    Gloria M Petersen
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 15:704-10. 2006
  3. ncbi request reprint Barriers to preventive intervention
    Gloria M Petersen
    Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Gastroenterol Clin North Am 31:1061-8, viii. 2002
  4. ncbi request reprint Changing trends in the incidence, stage, survival, and screen-detection of colorectal cancer: a population-based study
    Amit K Gupta
    Division of General Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA
    Clin Gastroenterol Hepatol 3:150-8. 2005
  5. pmc Irritable bowel syndrome aggregates strongly in families: a family-based case-control study
    Y A Saito
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Neurogastroenterol Motil 20:790-7. 2008
  6. doi request reprint Mutational analysis of thirty-two double-strand DNA break repair genes in breast and pancreatic cancers
    Xianshu Wang
    Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Cancer Res 68:971-5. 2008
  7. pmc Colorectal cancer risks in relatives of young-onset cases: is risk the same across all first-degree relatives?
    Lisa A Boardman
    Division of Gastroenterology, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Clin Gastroenterol Hepatol 5:1195-8. 2007
  8. ncbi request reprint Frequency of loss of hMLH1 expression in colorectal carcinoma increases with advancing age
    Sanjay Kakar
    Department of Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer 97:1421-7. 2003
  9. ncbi request reprint A genetic association study of 5-HTT LPR and GNbeta3 C825T polymorphisms with irritable bowel syndrome
    Y A Saito
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Neurogastroenterol Motil 19:465-70. 2007
  10. ncbi request reprint Increased prevalence of antimitochondrial antibodies in first-degree relatives of patients with primary biliary cirrhosis
    Konstantinos N Lazaridis
    Center for Basic Research in Digestive Diseases, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Hepatology 46:785-92. 2007

Detail Information

Publications69

  1. ncbi request reprint Genetic testing
    G M Petersen
    Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA
    Hematol Oncol Clin North Am 14:939-52. 2000
    ....
  2. ncbi request reprint Pancreatic cancer genetic epidemiology consortium
    Gloria M Petersen
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 15:704-10. 2006
    ..Linkage studies are ongoing. The PACGENE Consortium will be a valuable family-based resource that will greatly enhance genetic epidemiology research in pancreatic cancer...
  3. ncbi request reprint Barriers to preventive intervention
    Gloria M Petersen
    Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Gastroenterol Clin North Am 31:1061-8, viii. 2002
    ..Remedies that reduce intrinsic and extrinsic barriers to screening adherence are needed...
  4. ncbi request reprint Changing trends in the incidence, stage, survival, and screen-detection of colorectal cancer: a population-based study
    Amit K Gupta
    Division of General Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA
    Clin Gastroenterol Hepatol 3:150-8. 2005
    ..This study assessed concurrent trends in CRC incidence, presentation, survival, mortality, and polypectomies in Olmsted County, Minnesota...
  5. pmc Irritable bowel syndrome aggregates strongly in families: a family-based case-control study
    Y A Saito
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Neurogastroenterol Motil 20:790-7. 2008
    ....
  6. doi request reprint Mutational analysis of thirty-two double-strand DNA break repair genes in breast and pancreatic cancers
    Xianshu Wang
    Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Cancer Res 68:971-5. 2008
    ....
  7. pmc Colorectal cancer risks in relatives of young-onset cases: is risk the same across all first-degree relatives?
    Lisa A Boardman
    Division of Gastroenterology, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Clin Gastroenterol Hepatol 5:1195-8. 2007
    ..However, for young-onset microsatellite stable (MSS) CRC, the familial risk for CRC is unknown...
  8. ncbi request reprint Frequency of loss of hMLH1 expression in colorectal carcinoma increases with advancing age
    Sanjay Kakar
    Department of Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer 97:1421-7. 2003
    ..The correlation between age at diagnosis and loss of expression of hMLH1 protein in patients with colorectal carcinoma (CRC) has not been evaluated systematically...
  9. ncbi request reprint A genetic association study of 5-HTT LPR and GNbeta3 C825T polymorphisms with irritable bowel syndrome
    Y A Saito
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Neurogastroenterol Motil 19:465-70. 2007
    ..05). This study suggests that the 5-HTT LPR polymorphism may be associated with mixed-IBS, but not IBS overall. No association was observed for the GNbeta3 C825T polymorphism with IBS overall or subtypes...
  10. ncbi request reprint Increased prevalence of antimitochondrial antibodies in first-degree relatives of patients with primary biliary cirrhosis
    Konstantinos N Lazaridis
    Center for Basic Research in Digestive Diseases, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Hepatology 46:785-92. 2007
    ..1% and 1%, respectively. Greater prevalence of AMA was found in female FDRs of PBC probands [sisters (20.7%), mothers (15.1%), and daughters (9.8%)] than in male FDRs [brothers (7.8%), fathers (3.7%), and sons (0%)]...
  11. pmc Pancreatic cancer-associated diabetes mellitus: prevalence and temporal association with diagnosis of cancer
    Suresh T Chari
    Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Gastroenterology 134:95-101. 2008
    ..The temporal association between diabetes mellitus and pancreatic cancer is poorly understood. We compared temporal patterns in diabetes prevalence in pancreatic cancer and controls...
  12. ncbi request reprint Mitochondrial genetic polymorphisms and pancreatic cancer risk
    Liang Wang
    Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 200 First Street Southwest, Stabile 241, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 16:1455-9. 2007
    ..Investigation of other mitochondrial genetic variations (i.e., nuclear-encoded mitochondrial proteins) would be necessary to elucidate any role of mitochondrial DNA variation in PC...
  13. ncbi request reprint Higher frequency of diploidy in young-onset microsatellite-stable colorectal cancer
    Lisa A Boardman
    Department of Gastroenterology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Clin Cancer Res 13:2323-8. 2007
    ..The clinicopathologic features of MSS CIN- CRC are not well delineated. We assessed the relationship between age and chromosomal instability (CIN) status as measured by ploidy and allelic imbalance in a series of MSS tumors...
  14. doi request reprint Development and preliminary validation of the cancer family impact scale for colorectal cancer
    Pamela S Sinicrope
    Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Genet Test 12:161-9. 2008
    ..The aim of our study was to develop a measure of how a family history of colorectal cancer (CRC) affects families from the viewpoint of unaffected family members...
  15. pmc Prevalence and clinical profile of pancreatic cancer-associated diabetes mellitus
    Rahul Pannala
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota
    Gastroenterology 134:981-7. 2008
    ..Information on the clinical profile of pancreatic cancer (PaC) associated diabetes (DM) is limited. We compared the prevalence and clinical characteristics of DM in subjects with and without PaC...
  16. pmc Polymorphisms in DNA repair genes, smoking, and pancreatic adenocarcinoma risk
    Robert R McWilliams
    Division of Medical Oncology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA
    Cancer Res 68:4928-35. 2008
    ..78; 95% CI, 1.28-6.04) or D711D (OR, 2.19; 95% CI, 1.01-4.73). No other significant differences in risk were identified. Minor alleles in DNA repair genes XPF/ERCC4 and XPD/ERCC2 were associated with altered risk for pancreatic cancer...
  17. pmc Perceptions of lung cancer risk and beliefs in screening accuracy of spiral computed tomography among high-risk lung cancer family members
    Pamela S Sinicrope
    Department of Psychiatry and Psychology, Mayo Clinic Rochester, Rochester, MN 55905, USA
    Acad Radiol 17:1012-25. 2010
    ..Our objective was to describe the effect of participation in SCT screening on participants' risk perceptions, worry, and expectations regarding the accuracy of the screening result...
  18. pmc Familial aggregation of irritable bowel syndrome: a family case-control study
    Yuri A Saito
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA
    Am J Gastroenterol 105:833-41. 2010
    ..The aims of this study were to (i) compare the prevalence of IBS in case-relatives with control-relatives, and (ii) determine whether gender, relationship, predominant symptom, and environmental risk factors affect familial aggregation...
  19. pmc A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33
    Gloria M Petersen
    Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Nat Genet 42:224-8. 2010
    ..19, 95% CI 1.11-1.27), maps to the CLPTM1L-TERT locus on 5p15.33, which is associated with multiple cancers. Our study has identified common susceptibility loci for pancreatic cancer that warrant follow-up studies...
  20. pmc Association of mitotic regulation pathway polymorphisms with pancreatic cancer risk and outcome
    Fergus J Couch
    Department of Laboratory Medicine and Pathology, Stabile 2 42, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 19:251-7. 2010
    ..Single nucleotide polymorphisms (SNP) in regulators of mitosis may promote chromosome missegregation and influence pancreatic cancer and/or survival...
  21. pmc Parent of origin effects on age at colorectal cancer diagnosis
    Noralane M Lindor
    Department of Medical Genetics, Mayo Clinic, Rochester, MN, USA
    Int J Cancer 127:361-6. 2010
    ....
  22. pmc Cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations and risk for pancreatic adenocarcinoma
    Robert R McWilliams
    Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA
    Cancer 116:203-9. 2010
    ..The purpose of this case-control study was to determine whether CFTR mutations confer a higher risk of pancreatic cancer...
  23. pmc Fluorescence in situ hybridization to visualize genetic abnormalities in interphase cells of acinar cell carcinoma, ductal adenocarcinoma, and islet cell carcinoma of the pancreas
    Gordon W Dewald
    Division of Laboratory Genetics, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 84:801-10. 2009
    ..To use fluorescence in situ hybridization (FISH) to visualize genetic abnormalities in interphase cell nuclei (interphase FISH) of acinar cell carcinoma, ductal adenocarcinoma, and islet cell carcinoma of the pancreas...
  24. pmc Functional and clinical significance of variants localized to 8q24 in colon cancer
    Mine S Cicek
    Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street Southwest, 920 Hilton Building, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 18:2492-500. 2009
    ..Finally, these risk alleles do not seem to be associated with survival...
  25. pmc Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk
    Robert R McWilliams
    Department of Oncology, Mayo Clinic, 200 First Street, Southwest, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 18:2549-52. 2009
    ..We hypothesized that common variants in these genes, single nucleotide polymorphisms (SNP), may also influence risk for pancreatic cancer development...
  26. pmc Nucleotide excision repair pathway polymorphisms and pancreatic cancer risk: evidence for role of MMS19L
    Robert R McWilliams
    Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA
    Cancer Epidemiol Biomarkers Prev 18:1295-302. 2009
    ..Single nucleotide polymorphisms (SNP) in the nucleotide excision repair pathway may encode alterations that affect DNA repair function and therefore influence the risk of pancreatic cancer development...
  27. pmc Germline PKHD1 mutations are protective against colorectal cancer
    Christopher J Ward
    Division of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Hum Genet 129:345-9. 2011
    ..0002). We also show that the carriage rate for PKHD1 mutations in the European population is higher than previous accepted at 3.2% (1:31 genomes)...
  28. ncbi request reprint The prevalence of BRCA2 mutations in familial pancreatic cancer
    Fergus J Couch
    Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Cancer Epidemiol Biomarkers Prev 16:342-6. 2007
    ..A total of 10 carriers from 180 families were identified, suggesting that BRCA2 mutations account for 6% of moderate and high-risk pancreatic cancer families...
  29. pmc Association of family history of specific cancers with a younger age of onset of pancreatic adenocarcinoma
    Robert R McWilliams
    Department of Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Clin Gastroenterol Hepatol 4:1143-7. 2006
    ..Pancreatic adenocarcinoma has been associated with several familial cancer syndromes that also predispose to other malignancies. Younger ages of onset of pancreatic cancer (PC) have been reported in families with these syndromes...
  30. pmc Lower cancer incidence in Amsterdam-I criteria families without mismatch repair deficiency: familial colorectal cancer type X
    Noralane M Lindor
    Department of Medical Genetics, Mayo Clinic, Rochester, Minn, USA
    JAMA 293:1979-85. 2005
    ..Cancer incidence in AC-I families with MMR gene mutations is reported to be very high, but cancer incidence for individuals in AC-I families with no evidence of an MMR defect is unknown...
  31. pmc Probability of pancreatic cancer following diabetes: a population-based study
    Suresh T Chari
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Rochester, Minnesota 55905, USA
    Gastroenterology 129:504-11. 2005
    ..Although diabetes occurs frequently in pancreatic cancer, the value of new-onset diabetes as a marker of underlying pancreatic cancer is unknown...
  32. ncbi request reprint The genetics of irritable bowel syndrome
    Yuri A Saito
    Clinical Enteric Neuroscience Translational and Epidemiological Research C E N T E R, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Clin Gastroenterol Hepatol 3:1057-65. 2005
    ....
  33. pmc Association of breast cancer susceptibility variants with risk of pancreatic cancer
    Fergus J Couch
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer Epidemiol Biomarkers Prev 18:3044-8. 2009
    ..Recently, several breast cancer susceptibility loci have been identified through genome-wide association studies. Here we evaluated possible associations between these single nucleotide polymorphisms (SNP) and pancreatic cancer risk...
  34. ncbi request reprint MYH mutations in patients with attenuated and classic polyposis and with young-onset colorectal cancer without polyps
    Liang Wang
    Department of Laboratory Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Gastroenterology 127:9-16. 2004
    ....
  35. pmc Interacting alleles of the coinhibitory immunoreceptor genes cytotoxic T-lymphocyte antigen 4 and programmed cell-death 1 influence risk and features of primary biliary cirrhosis
    Brian D Juran
    Center for Basic Research in Digestive Diseases, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Hepatology 47:563-70. 2008
    ..As well, we identified the influence of an interaction between the putatively autoimmune-protective CTLA4 49AG:CT60 AA haplotype and autoimmune-risk PDCD1 PD1.3 A allele on development of PBC...
  36. ncbi request reprint Immunohistochemistry versus microsatellite instability testing in phenotyping colorectal tumors
    Noralane M Lindor
    Department of Medical Genetics, Mayo Foundation, Rochester, MN 55905, USA
    J Clin Oncol 20:1043-8. 2002
    ..To compare microsatellite instability (MSI) testing with immunohistochemical (IHC) detection of hMLH1 and hMSH2 in colorectal cancer...
  37. ncbi request reprint Risk of malignancy in first-degree relatives of patients with pancreatic carcinoma
    Robert R McWilliams
    Department of Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Cancer 104:388-94. 2005
    ..Counseling the families of PC patients regarding their risk of cancer remains problematic because little information is available...
  38. ncbi request reprint Genomics, genetic epidemiology, and genomic medicine
    Konstantinos N Lazaridis
    Division of Gastroenterology and Hepatology, Center for Basic Research in Digestive Diseases, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Clin Gastroenterol Hepatol 3:320-8. 2005
    ..In this inaugural article, we introduce and discuss concepts, facts, and methods of genomics and genetic epidemiology that will be drawn on in the forthcoming topics of the clinical genomics series...
  39. pmc Prevalence of CDKN2A mutations in pancreatic cancer patients: implications for genetic counseling
    Robert R McWilliams
    Department of Oncology, Mayo Clinic, Rochester, MN, USA
    Eur J Hum Genet 19:472-8. 2011
    ..Carriers of germline mutations of CDKN2A should be counseled to avoid tobacco use to decrease risk of pancreatic cancer in addition to taking measures to decrease melanoma risk...
  40. pmc Temporal association of changes in fasting blood glucose and body mass index with diagnosis of pancreatic cancer
    Rahul Pannala
    Department of Gastroenterology and Hepatology, Fiterman Center for Digestive Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Gastroenterol 104:2318-25. 2009
    ..Although the association between diabetes mellitus (DM) and pancreatic cancer is well described, temporal patterns of changes in fasting blood glucose (FBG) and body mass index (BMI) before pancreatic cancer diagnosis are not known...
  41. ncbi request reprint Recommendations for the care of individuals with an inherited predisposition to Lynch syndrome: a systematic review
    Noralane M Lindor
    Department of Medical Genetics, Mayo Clinic College of Medicine, Rochester, Minn, USA
    JAMA 296:1507-17. 2006
    ..Potential risk-reducing interventions are recommended for individuals known to have these mutations...
  42. ncbi request reprint The APC E1317Q variant in adenomatous polyps and colorectal cancers
    D Hahnloser
    Division of Colon and Rectal Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer Epidemiol Biomarkers Prev 12:1023-8. 2003
    ..These results underscore the importance of carefully defining the controls to be used in comparisons of allele frequencies...
  43. pmc Pancreatic neuroendocrine tumors (PNETs): incidence, prognosis and recent trend toward improved survival
    T R Halfdanarson
    Division of Medical Oncology, Mayo Clinic College of Medicine, Rochester, MN, USA
    Ann Oncol 19:1727-33. 2008
    ..Pancreatic neuroendocrine tumors (PNETs) are uncommon neoplasms that can present with symptoms of hormone overproduction. We evaluated the incidence, prognosis, and temporal trends of PNETs...
  44. pmc New-onset diabetes: a potential clue to the early diagnosis of pancreatic cancer
    Rahul Pannala
    Miles and Shirley Fiterman Center for Digestive Diseases, Mayo Clinic, Rochester, MN, USA
    Lancet Oncol 10:88-95. 2009
    ....
  45. pmc Pancreatic endocrine neoplasms: epidemiology and prognosis of pancreatic endocrine tumors
    Thorvardur R Halfdanarson
    Division of Oncology, Department of Medical Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Endocr Relat Cancer 15:409-27. 2008
    ..The epidemiology, prognosis, and established and novel prognostic markers of PETs are reviewed...
  46. pmc Long-term survival and prognostic indicators in small (<or=2 cm) pancreatic cancer
    Supot Pongprasobchai
    Division of Gastroenterology, Mayo Clinic, Rochester, MN 55905, USA
    Pancreatology 8:587-92. 2008
    ..In a matched analysis, we investigated clinical, histopathological, and survival characteristics of small (<or=2 cm) pancreatic cancer (PaC) as compared to large PaC...
  47. ncbi request reprint Case-control genetic association studies in gastrointestinal disease: review and recommendations
    Yuri A Saito
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Gastroenterol 101:1379-89. 2006
    ..Recommendations for reporting the results of a genetic association study are provided to assist with study planning and manuscript preparation...
  48. ncbi request reprint Familial pancreatic cancer: where are we in 2003?
    Gloria M Petersen
    J Natl Cancer Inst 95:180-1. 2003
  49. ncbi request reprint Genetic testing for hereditary colorectal cancer in children: long-term psychological effects
    Ann Marie Codori
    Department of Psychiatry and Behavioral Sciences, School of Medicine, The Johns Hopkins University, Baltimore, Maryland, USA
    Am J Med Genet A 116:117-28. 2003
    ..Our findings should call for a multidisciplinary approach to genetic testing for children...
  50. ncbi request reprint Cancer risks in BRCA1 carriers: time for the next generation of studies
    Stephen B Gruber
    J Natl Cancer Inst 94:1344-5. 2002
  51. ncbi request reprint Evidence for a major gene influencing risk of pancreatic cancer
    Alison P Klein
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    Genet Epidemiol 23:133-49. 2002
    ..This hospital-based segregation analysis of pancreatic cancer found evidence supporting the role of a rare major gene influencing risk of pancreatic cancer...
  52. ncbi request reprint Evaluation of candidate genes MAP2K4, MADH4, ACVR1B, and BRCA2 in familial pancreatic cancer: deleterious BRCA2 mutations in 17%
    Kathleen M Murphy
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Cancer Res 62:3789-93. 2002
    ..These findings confirm the increased risk of pancreatic cancer in individuals with BRCA2 mutations and identify germ-line BRCA2 mutations as the most common inherited genetic alteration yet identified in familial pancreatic cancer...
  53. ncbi request reprint Prospective risk of pancreatic cancer in familial pancreatic cancer kindreds
    Alison P Klein
    Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, NIH, Baltimore, Maryland, USA
    Cancer Res 64:2634-8. 2004
    ..Risk was higher in smokers than in nonsmokers. Individuals with a strong family history of pancreatic cancer have a significantly increased risk of developing pancreatic cancer...
  54. ncbi request reprint Impact of genetic counseling and testing on colorectal cancer screening behavior
    Karen A Johnson
    Oncology Center, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Genet Test 6:303-6. 2002
    ..However, patients with negative results may receive false reassurance about cancer risks and fail to follow recommended screening. Emphasis should be placed on the importance of screening even when genetic test results are negative...
  55. ncbi request reprint Screening for pancreatic neoplasia in high-risk individuals: an EUS-based approach
    Marcia Irene Canto
    Department of Medicine Gastroenterology, Johns Hopkins Medical Institution, Baltimore, MD 21205, USA
    Clin Gastroenterol Hepatol 2:606-21. 2004
    ..We prospectively evaluated the feasibility of screening for pancreatic neoplasia in high-risk individuals...
  56. pmc Mitochondrial genetic polymorphisms do not predict survival in patients with pancreatic cancer
    Thorvardur R Halfdanarson
    Department of Internal Medicine, Division of Hematology, Oncology and Blood and Marrow Transplantation, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
    Cancer Epidemiol Biomarkers Prev 17:2512-3. 2008
    ..After adjusting for covariates and multiple comparisons, no association between any of the mitochondrial single nucleotide polymorphisms or haplogroups and survival was observed...
  57. pmc Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer
    Pengyuan Liu
    Washington University, St Louis, MO 63110, USA
    J Natl Cancer Inst 100:1326-30. 2008
    ..67, CI = 2.21 to 14.60, both of which were located in the 15q24-25.1 locus, than among control subjects. Thus, further research to elucidate causal variants in the 15q24-25.1 locus that are associated with lung cancer is warranted...
  58. pmc Linkage analysis of chromosome 4 in families with familial pancreatic cancer
    Alison P Klein
    The Sol Goldman Pancreatic Research Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Cancer Biol Ther 6:320-3. 2007
    ....
  59. ncbi request reprint Genome-wide allelotypes of familial pancreatic adenocarcinomas and familial and sporadic intraductal papillary mucinous neoplasms
    Tadayoshi Abe
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Clin Cancer Res 13:6019-25. 2007
    ..Identifying the genomic losses that occur in pancreatic neoplasms, particularly those that occur in familial and precursor neoplasms, may help localize the genes responsible for pancreatic cancer susceptibility...
  60. pmc EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity
    Haris Vikis
    Washington University, St Louis, Missouri, USA
    Cancer Res 67:4665-70. 2007
    ..Our observations show that EGFR-T790M provides a proliferative advantage with respect to WT EGFR and suggest that the enhanced kinase activity of this mutant is the basis for rare cases of inherited susceptibility to lung cancer...
  61. pmc Identification of a novel tumor suppressor gene p34 on human chromosome 6q25.1
    Min Wang
    School of Medicine, Washington University, 660 Euclid Avenue, St Louis, MO, USA
    Cancer Res 67:93-9. 2007
    ..Our results suggest that p34 may be a novel tumor suppressor gene involved in sporadic lung cancer but it seems not to be the candidate familial lung cancer susceptibility gene linked to chromosomal region 6q23-25...
  62. ncbi request reprint Genetic epidemiology of melanoma: of consortia and conundrums
    Gloria M Petersen
    J Natl Cancer Inst 94:872-3. 2002
  63. ncbi request reprint Creating tomorrow's leaders in cancer prevention: a novel interdisciplinary career development program in cancer genetics research
    Kathleen R Blazer
    City of Hope Cancer Center, Duarte, CA 91010, USA
    J Cancer Educ 21:216-22. 2006
    ..To prepare oncology, genetics and molecular medicine professionals for basic, translational and epidemiological cancer genetics research through advanced training in a novel specialized cancer genetics career development program (CGCDP)...
  64. ncbi request reprint Opportunities and barriers in the age of team science: strategies for success
    Thomas A Sellers
    Division of Cancer Prevention and Control, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Cancer Causes Control 17:229-37. 2006
    ..To provide the voice of experience to investigators contemplating engagement in the realm of "team science"...
  65. ncbi request reprint Genetic counseling outcomes: perceived risk and distress after counseling for hereditary colorectal cancer
    Ann Marie Codori
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Genet Couns 14:119-32. 2005
    ..The findings suggest counseling interventions that should increase the likelihood of screening and offer hypotheses for future research...
  66. ncbi request reprint Screening for early pancreatic neoplasia in high-risk individuals: a prospective controlled study
    Marcia Irene Canto
    Depatment of Medicine Gastroenterology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Clin Gastroenterol Hepatol 4:766-81; quiz 665. 2006
    ..This study screened for early pancreatic neoplasia and compared the pancreatic abnormalities in high-risk individuals and control subjects...
  67. pmc Diagnosis of pancreatic cancer using serum proteomic profiling
    Sudeepa Bhattacharyya
    Center for Orthopaedic Research, Department of Orthopaedic Surgery, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Neoplasia 6:674-86. 2004
    ..These results suggest that high-throughput proteomics profiling has the capacity to provide new biomarkers for the early detection and diagnosis of PCa...
  68. ncbi request reprint Role and limitations of epidemiology in establishing a causal association
    Eduardo L Franco
    Department of Epidemiology, McGill University, 546 Pine Avenue West, Montreal, QC, Canada H2W1S6
    Semin Cancer Biol 14:413-26. 2004
    ..Both examples serve as paradigms of successful cooperation between epidemiologists and laboratory scientists in the pursuit of the understanding of cancer etiology...
  69. ncbi request reprint Familial aggregation of fainting in a case-control study of neurally mediated hypotension patients who present with unexplained chronic fatigue
    Katherine E Lucas
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, E6148, Baltimore, MD 21205, USA
    Europace 8:846-51. 2006
    ..We hypothesized that family history of fainting is a risk factor for adult-onset neurally mediated hypotension (NMH) in patients who present with chronic fatigue rather than fainting...