William Perkins

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Carotid stenting vs endarterectomy: new results in perspective
    William J Perkins
    Department of Anesthesiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Mayo Clin Proc 85:1101-8. 2010
  2. pmc Prolonged NO treatment decreases alpha-adrenoreceptor agonist responsiveness in porcine pulmonary artery due to persistent soluble guanylyl cyclase activation
    William J Perkins
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Am J Physiol Lung Cell Mol Physiol 296:L666-73. 2009
  3. pmc Prolonged treatment of porcine pulmonary artery with nitric oxide decreases cGMP sensitivity and cGMP-dependent protein kinase specific activity
    William J Perkins
    Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Am J Physiol Lung Cell Mol Physiol 296:L121-9. 2009
  4. ncbi request reprint A retained Racz catheter fragment after epidural neurolysis: implications during magnetic resonance imaging
    William J Perkins
    Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Anesth Analg 96:1717-9, table of contents. 2003
  5. ncbi request reprint Reduction in soluble guanylyl cyclase-specific activity following prolonged treatment of porcine pulmonary artery with nitric oxide
    William J Perkins
    Department of Anesthesiology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Am J Physiol Lung Cell Mol Physiol 293:L84-95. 2007
  6. ncbi request reprint Nitric oxide sensitivity in pulmonary artery and airway smooth muscle: a possible role for cGMP responsiveness
    Miwa Taniguchi
    Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Am J Physiol Lung Cell Mol Physiol 290:L1018-27. 2006
  7. ncbi request reprint NO responsiveness in pulmonary artery and airway smooth muscle: the role of cGMP regulation
    Young L Kwak
    Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Am J Physiol Lung Cell Mol Physiol 290:L200-8. 2006
  8. ncbi request reprint Differential effects of soluble and particulate guanylyl cyclase on Ca(2+) sensitivity in airway smooth muscle
    Edwin H Rho
    Department of Anesthesiology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    J Appl Physiol 92:257-63. 2002
  9. doi request reprint Airway management in patients who develop neck hematomas after carotid endarterectomy
    William A Shakespeare
    Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, Minnesota 55902, USA
    Anesth Analg 110:588-93. 2010
  10. doi request reprint Awake craniotomy, electrophysiologic mapping, and tumor resection with high-field intraoperative MRI
    Ian F Parney
    Department of Neurologic Surgery, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    World Neurosurg 73:547-51. 2010

Research Grants

  1. Nitric Oxide Tolerance in Smooth Muscle
    William Perkins; Fiscal Year: 2005

Collaborators

Detail Information

Publications17

  1. pmc Carotid stenting vs endarterectomy: new results in perspective
    William J Perkins
    Department of Anesthesiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Mayo Clin Proc 85:1101-8. 2010
    ....
  2. pmc Prolonged NO treatment decreases alpha-adrenoreceptor agonist responsiveness in porcine pulmonary artery due to persistent soluble guanylyl cyclase activation
    William J Perkins
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Am J Physiol Lung Cell Mol Physiol 296:L666-73. 2009
    ..We conclude that prolonged NO exposure results in a persistently increased sGC specific activity, which accounts for the observed alpha-adrenoreceptor agonist hyporesponsiveness...
  3. pmc Prolonged treatment of porcine pulmonary artery with nitric oxide decreases cGMP sensitivity and cGMP-dependent protein kinase specific activity
    William J Perkins
    Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Am J Physiol Lung Cell Mol Physiol 296:L121-9. 2009
    ..min(-1).ng cGKI(-1), respectively). We conclude that prolonged NO treatment induces decreased acute NO responsiveness in PA in part by decreasing cGMP sensitivity. It does so by decreasing both cGKI expression and cGKI specific activity...
  4. ncbi request reprint A retained Racz catheter fragment after epidural neurolysis: implications during magnetic resonance imaging
    William J Perkins
    Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Anesth Analg 96:1717-9, table of contents. 2003
    ..The implications of this are discussed in light of other reports of retained catheter fragments obtained from the Food and Drug Administration Manufacturer and Facility Device Experience Database (http://www.fda.gov/cdrh/maude.html)...
  5. ncbi request reprint Reduction in soluble guanylyl cyclase-specific activity following prolonged treatment of porcine pulmonary artery with nitric oxide
    William J Perkins
    Department of Anesthesiology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Am J Physiol Lung Cell Mol Physiol 293:L84-95. 2007
    ..We conclude that prolonged NO treatment induces decreased acute NO responsiveness in part by decreasing both sGC expression and sGC-specific activity...
  6. ncbi request reprint Nitric oxide sensitivity in pulmonary artery and airway smooth muscle: a possible role for cGMP responsiveness
    Miwa Taniguchi
    Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Am J Physiol Lung Cell Mol Physiol 290:L1018-27. 2006
    ..A novel intrinsic smooth muscle mechanism accounting for greater NO responsiveness in PASM vs. TSM is thus greater cGMP responsiveness from increased cGKI-specific activity in PASM...
  7. ncbi request reprint NO responsiveness in pulmonary artery and airway smooth muscle: the role of cGMP regulation
    Young L Kwak
    Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Am J Physiol Lung Cell Mol Physiol 290:L200-8. 2006
    ..An intrinsic smooth muscle mechanism accounting for greater NO responsiveness in PASM vs. TSM is greater sGC activity...
  8. ncbi request reprint Differential effects of soluble and particulate guanylyl cyclase on Ca(2+) sensitivity in airway smooth muscle
    Edwin H Rho
    Department of Anesthesiology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    J Appl Physiol 92:257-63. 2002
    ..Thus, during muscarinic stimulation, stimulation of pGC relaxes ASM exclusively by decreasing [Ca(2+)](i), whereas stimulation of sGC decreases both [Ca(2+)](i) and Ca(2+) sensitivity...
  9. doi request reprint Airway management in patients who develop neck hematomas after carotid endarterectomy
    William A Shakespeare
    Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, Minnesota 55902, USA
    Anesth Analg 110:588-93. 2010
    ..Despite this, the relationship of airway management technique to patient outcome has not been systematically studied in this population. We report the rate of successful airway management using various techniques in post-CEA patients...
  10. doi request reprint Awake craniotomy, electrophysiologic mapping, and tumor resection with high-field intraoperative MRI
    Ian F Parney
    Department of Neurologic Surgery, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    World Neurosurg 73:547-51. 2010
    ..Standard draping protocols in high-field iMRI units make awake craniotomies challenging, and only two groups have previously reported combined EPM and high-field iMRI...
  11. ncbi request reprint Anesthetics inhibit acetylcholine-promoted guanine nucleotide exchange of heterotrimeric G proteins of airway smooth muscle
    Chie Sakihara
    Department of Anesthesiology, Mayo Foundation, Rochester, Minnesota 55905, USA
    Anesthesiology 101:120-6. 2004
    ..e., they inhibit muscarinic receptor-Galphaq/11 coupling)...
  12. ncbi request reprint The effects of hexanol on Galpha(i) subunits of heterotrimeric G proteins
    John Streiff
    Departments of Anesthesiology and Physiology and Biophysics, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Anesth Analg 98:660-7, table of contents. 2004
    ..This finding implies that this is not a mechanism by which hexanol interferes with receptor-G protein function...
  13. ncbi request reprint Dual effects of hexanol and halothane on the regulation of calcium sensitivity in airway smooth muscle
    Hayashi Yoshimura
    Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Anesthesiology 98:871-80. 2003
    ..The authors tested the hypothesis that hexanol, like halothane, inhibits agonist-induced increases in calcium sensitivity in airway smooth muscle by inhibiting G-protein pathways...
  14. ncbi request reprint Effects of primary alcohols on airway smooth muscle
    Chie Sakihara
    Department of Anesthesiology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Anesthesiology 96:428-37. 2002
    ....
  15. ncbi request reprint Prolonged relaxation consistent with persistent soluble guanylyl cyclase activation in canine pulmonary artery following brief treatment with nitric oxide donors
    Young L Kwak
    Department of Anesthesia and Pain Medicine, Yonsei University College of Medicine, Republic of Korea
    Life Sci 79:2001-9. 2006
    ..Reversal of this cGMP-dependent process with DTT suggests that it occurs via mechanisms that are thiol redox sensitive...
  16. ncbi request reprint Regulation of soluble guanylyl cyclase: looking beyond NO
    William J Perkins
    Am J Physiol Lung Cell Mol Physiol 291:L334-6. 2006
  17. ncbi request reprint H(2)O(2)-induced kinetic and chemical modifications of smooth muscle myosin: correlation to effects of H(2)O(2) on airway smooth muscle
    Alan R Penheiter
    Department of Biochemistry and Molecular Biology, University of Nevada School of Medicine, Reno, Nevada 89557, USA
    J Biol Chem 282:4336-44. 2007
    ..These data, when compared with the in vitro kinetic data, are consistent with a H(2)O(2)-induced loss of functional myosin heads in the muscle...

Research Grants4

  1. Nitric Oxide Tolerance in Smooth Muscle
    William Perkins; Fiscal Year: 2005
    ..We will use a combination of pharmacological probes and novel antisense oligomers to determine the mechanism by which chronic NO treatment decreases the expression and activity of sGC subunits and cGK isoforms. ..