Carmen Perez-Terzic

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Stem cell systems informatics for advanced clinical biodiagnostics: tracing molecular signatures from bench to bedside
    Randolph S Faustino
    C Perez Terzic, Mayo Clinic, 200 First Street SW, Rochester, MN, USA 55905
    Croat Med J 54:319-29. 2013
  2. doi request reprint Exercise in cardiovascular diseases
    Carmen M Perez-Terzic
    Cardiovascular Rehabilitation Program, Department of Physical Medicine and Rehabilitation, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    PM R 4:867-73. 2012
  3. pmc Cardiopoietic programming of embryonic stem cells for tumor-free heart repair
    Atta Behfar
    Marriott Heart Disease Research Program, Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Exp Med 204:405-20. 2007
  4. ncbi request reprint Administration of allogenic stem cells dosed to secure cardiogenesis and sustained infarct repair
    Atta Behfar
    Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Ann N Y Acad Sci 1049:189-98. 2005
  5. pmc iPS programmed without c-MYC yield proficient cardiogenesis for functional heart chimerism
    Almudena Martinez-Fernandez
    Marriott Heart Disease Research Program, Division of Cardiovascular Diseases, Departments of Medicine, Molecular Pharmacology and Experimental Therapeutics, and Medical Genetics, Mayo Clinic, Rochester, Minn 55905, USA
    Circ Res 105:648-56. 2009
  6. pmc Nuclear reprogramming with c-Myc potentiates glycolytic capacity of derived induced pluripotent stem cells
    Clifford D L Folmes
    Center for Regenerative Medicine and Marriott Heart Disease Research Program, Division of Cardiovascular Diseases, Departments of Medicine, Molecular Pharmacology and Experimental Therapeutics, and Medical Genetics, Mayo Clinic, Rochester, MN, USA
    J Cardiovasc Transl Res 6:10-21. 2013
  7. pmc Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming
    Clifford D L Folmes
    Center for Regenerative Medicine and Marriott Heart Disease Research Program, Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Cell Metab 14:264-71. 2011
  8. pmc Guided cardiopoiesis enhances therapeutic benefit of bone marrow human mesenchymal stem cells in chronic myocardial infarction
    Atta Behfar
    Department of Medicine, Division of Cardiovascular Diseases, Marriott Heart Disease Research Program, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 56:721-34. 2010
  9. pmc Kir6.2 is required for adaptation to stress
    Leonid V Zingman
    Division of Cardiovascular Diseases, Departments of Medicine and Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA
    Proc Natl Acad Sci U S A 99:13278-83. 2002
  10. ncbi request reprint ATP-sensitive K+ channel knockout compromises the metabolic benefit of exercise training, resulting in cardiac deficits
    Garvan C Kane
    Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Diabetes 53:S169-75. 2004

Collaborators

Detail Information

Publications31

  1. pmc Stem cell systems informatics for advanced clinical biodiagnostics: tracing molecular signatures from bench to bedside
    Randolph S Faustino
    C Perez Terzic, Mayo Clinic, 200 First Street SW, Rochester, MN, USA 55905
    Croat Med J 54:319-29. 2013
    ....
  2. doi request reprint Exercise in cardiovascular diseases
    Carmen M Perez-Terzic
    Cardiovascular Rehabilitation Program, Department of Physical Medicine and Rehabilitation, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    PM R 4:867-73. 2012
    ..This review will discuss an exercise prescription for patients with coronary artery disease, heart failure, and after heart transplantation. Detailed precautions for particular groups of patients will be discussed...
  3. pmc Cardiopoietic programming of embryonic stem cells for tumor-free heart repair
    Atta Behfar
    Marriott Heart Disease Research Program, Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Exp Med 204:405-20. 2007
    ..Thus, cardiopoietic programming establishes a strategy to hone stem cell pluripotency, offering a tumor-resistant approach for regeneration...
  4. ncbi request reprint Administration of allogenic stem cells dosed to secure cardiogenesis and sustained infarct repair
    Atta Behfar
    Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Ann N Y Acad Sci 1049:189-98. 2005
    ..Supported by the host environment, proper dosing and administration of embryonic stem cells is thus here shown useful in the chronic management of cardiac injury promoting sustained repair...
  5. pmc iPS programmed without c-MYC yield proficient cardiogenesis for functional heart chimerism
    Almudena Martinez-Fernandez
    Marriott Heart Disease Research Program, Division of Cardiovascular Diseases, Departments of Medicine, Molecular Pharmacology and Experimental Therapeutics, and Medical Genetics, Mayo Clinic, Rochester, Minn 55905, USA
    Circ Res 105:648-56. 2009
    ..Induced pluripotent stem cells (iPS) allow derivation of pluripotent progenitors from somatic sources. Originally, iPS were induced by a stemness-related gene set that included the c-MYC oncogene...
  6. pmc Nuclear reprogramming with c-Myc potentiates glycolytic capacity of derived induced pluripotent stem cells
    Clifford D L Folmes
    Center for Regenerative Medicine and Marriott Heart Disease Research Program, Division of Cardiovascular Diseases, Departments of Medicine, Molecular Pharmacology and Experimental Therapeutics, and Medical Genetics, Mayo Clinic, Rochester, MN, USA
    J Cardiovasc Transl Res 6:10-21. 2013
    ..Thus, inclusion of c-Myc potentiates the pluripotent glycolytic behavior of derived iPS cells, supporting c-Myc-free reprogramming as a strategy to facilitate oxidative metabolism-dependent lineage engagement...
  7. pmc Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming
    Clifford D L Folmes
    Center for Regenerative Medicine and Marriott Heart Disease Research Program, Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Cell Metab 14:264-71. 2011
    ..Thus, the energetic infrastructure of somatic cells transitions into a required glycolytic metabotype to fuel induction of pluripotency...
  8. pmc Guided cardiopoiesis enhances therapeutic benefit of bone marrow human mesenchymal stem cells in chronic myocardial infarction
    Atta Behfar
    Department of Medicine, Division of Cardiovascular Diseases, Marriott Heart Disease Research Program, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 56:721-34. 2010
    ..The goal of this study was to guide bone marrow-derived human mesenchymal stem cells (hMSCs) into a cardiac progenitor phenotype and assess therapeutic benefit in chronic myocardial infarction...
  9. pmc Kir6.2 is required for adaptation to stress
    Leonid V Zingman
    Division of Cardiovascular Diseases, Departments of Medicine and Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA
    Proc Natl Acad Sci U S A 99:13278-83. 2002
    ..In the absence of Kir6.2, vigorous sympathetic challenge caused arrhythmia and sudden death, preventable by calcium-channel blockade. Thus, this vital function identifies a physiological role for K(ATP) channels in the heart...
  10. ncbi request reprint ATP-sensitive K+ channel knockout compromises the metabolic benefit of exercise training, resulting in cardiac deficits
    Garvan C Kane
    Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Diabetes 53:S169-75. 2004
    ..Thus, Kir6.2-containing K(ATP) channel activity is required for attainment of the physiologic benefits of exercise training without injury...
  11. pmc Embryonic stem cell therapy of heart failure in genetic cardiomyopathy
    Satsuki Yamada
    Department of Medicine, Division of Cardiovascular Diseases, Marriott Heart Disease Research Program, Mayo Clinic, Rochester, Minnesota, USA 55905, USA
    Stem Cells 26:2644-53. 2008
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  12. pmc Decoded calreticulin-deficient embryonic stem cell transcriptome resolves latent cardiophenotype
    Randolph S Faustino
    Marriott Heart Disease Research Program, Division of Cardiovascular Diseases, Departments of Medicine, Molecular Pharmacology and Experimental Therapeutics, and Medical Genetics, Mayo Clinic, Rochester, Minnesota 55905, USA
    Stem Cells 28:1281-91. 2010
    ....
  13. ncbi request reprint CXCR4+ and FLK-1+ identify circulating cells associated with improved cardiac function in patients following myocardial infarction
    Rahul Suresh
    Mayo Medical School, College of Medicine, Rochester, MN, USA
    J Cardiovasc Transl Res 6:787-97. 2013
    ..Thus, CD45(-)/CXCR4(+)/FLK-1(+) cells may provide a diagnostic tool to follow cardiac regenerative capacity and potentially serve as a prognostic marker in AMI. ..
  14. pmc Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency
    Darren J Baker
    Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Nat Cell Biol 10:825-36. 2008
    ..Thus, we identify BubR1 insufficiency as a trigger for activation of the Cdkn2a locus in certain mouse tissues, and demonstrate that p16(Ink4a) is an effector and p19(Arf) an attenuator of senescence and ageing in these tissues...
  15. pmc Induced pluripotent stem cell intervention rescues ventricular wall motion disparity, achieving biological cardiac resynchronization post-infarction
    Satsuki Yamada
    A Terzic Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Physiol 591:4335-49. 2013
    ..Thus, in ischaemic cardiomyopathy, targeted iPS cell transplantation synchronized failing ventricles, offering a regenerative strategy to achieve biological resynchronization...
  16. ncbi request reprint Stem cells transform into a cardiac phenotype with remodeling of the nuclear transport machinery
    Carmen Perez-Terzic
    Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Nat Clin Pract Cardiovasc Med 4:S68-76. 2007
    ....
  17. pmc Guided stem cell cardiopoiesis: discovery and translation
    Atta Behfar
    Marriott Heart Disease Research Program, Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Mol Cell Cardiol 45:523-9. 2008
    ..With appropriate validation of this newly derived cardiopoietic phenotype, the next generation of trials should achieve demonstrable benefit across patient populations...
  18. doi request reprint Availability and characteristics of cardiovascular rehabilitation programs in South America
    Mery Cortés-Bergoderi
    Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA
    J Cardiopulm Rehabil Prev 33:33-41. 2013
    ..This study was carried out to assess the characteristics and current level of CR program implementation in South America...
  19. pmc Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice
    Darren J Baker
    Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Cell Biol 172:529-40. 2006
    ..Our findings suggest that early onset of aging-associated phenotypes in mice with mitotic checkpoint gene defects is linked to cellular senescence and activation of the p53 and p16 pathways rather than to aneuploidy...
  20. pmc Mitochondrial oxidative metabolism is required for the cardiac differentiation of stem cells
    Susan Chung
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Nat Clin Pract Cardiovasc Med 4:S60-7. 2007
    ..Mitochondria-dependent energetic circuits are thus critical regulators of de novo cardiogenesis and targets for heart regeneration...
  21. pmc Disease-causing mitochondrial heteroplasmy segregated within induced pluripotent stem cell clones derived from a patient with MELAS
    Clifford D L Folmes
    Department of Medicine, Mayo Clinic, Rochester, MN, USA
    Stem Cells 31:1298-308. 2013
    ....
  22. pmc Repair of acute myocardial infarction by human stemness factors induced pluripotent stem cells
    Timothy J Nelson
    Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Circulation 120:408-16. 2009
    ..Induced pluripotent stem cells (iPS) demonstrate aptitude for de novo cardiac differentiation, yet their potential for heart disease therapy has not been tested...
  23. ncbi request reprint Transgenic overexpression of human DMPK accumulates into hypertrophic cardiomyopathy, myotonic myopathy and hypotension traits of myotonic dystrophy
    D Fearghas O'Cochlain
    Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Hum Mol Genet 13:2505-18. 2004
    ..Proper expression of hDMPK is, therefore, mandatory in supporting the integral balance among cytoarchitectural infrastructure, ion-homeostasis and viability control in various muscle cell types...
  24. pmc Genomic chart guiding embryonic stem cell cardiopoiesis
    Randolph S Faustino
    Marriott Heart Disease Research Program, Division of Cardiovascular Diseases, Departments of Medicine, Molecular Pharmacology and Experimental Therapeutics, and Medical Genetics, Mayo Clinic, Rochester, Minnesota 55905, USA
    Genome Biol 9:R6. 2008
    ..To map molecular patterns critical to cardiogenesis, we interrogated gene expression in stem cells undergoing guided differentiation, and defined a genomic paradigm responsible for confinement of pluripotency...
  25. pmc Cardiac cell repair therapy: a clinical perspective
    Bernard J Gersh
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 84:876-92. 2009
    ..An interdisciplinary effort across the scientific and clinical community within academia, biotechnology, and government will drive the successful realization of this next generation of therapeutic agents for the "broken" heart...
  26. ncbi request reprint Validity of cardiovascular risk prediction models in Latin America and among Hispanics in the United States of America: a systematic review
    Mery Cortés-Bergoderi
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, United States of America
    Rev Panam Salud Publica 32:131-9. 2012
    ..To assess the use and validity of prediction models to estimate the risk of cardiovascular disease (CVD) in Latin America and among Hispanic populations in the United States of America...
  27. ncbi request reprint Is exercise training safe and beneficial in patients receiving left ventricular assist device therapy?
    Osama Alsara
    Department of Internal Medicine, Michigan State University, East Lansing Dr Alsara Department of Internal Medicine, Division of Cardiovascular Diseases and Internal Medicine, Cardiovascular Health Clinic, Rochester, Minnesota Drs Perez Terzic, Squires, and Thomas and Department of Physical Medicine and Rehabilitation Dr Perez Terzic, Department of Internal Medicine, Division of General Internal Medicine Drs Dandamudi and Miranda, and Department of Surgery, Division of Cardiovascular Surgery Dr Park, Mayo Clinic, Rochester, Minnesota
    J Cardiopulm Rehabil Prev 34:233-40. 2014
    ....
  28. ncbi request reprint Channelopathies: decoding disease pathogenesis
    Andre Terzic
    Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Sci Transl Med 2:42ps37. 2010
    ..Advances in the molecular medicine of K(ATP) channelopathies offer new perspectives for personalized diagnosis and therapy...
  29. doi request reprint Current status of cardiac rehabilitation in Latin America and the Caribbean
    Yoel Korenfeld
    Cardiovascular Division, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Am Heart J 158:480-7. 2009
    ..Advanced resources for the diagnosis and treatment of CAD are available in most of the region. However, preventive approaches such as cardiovascular rehabilitation programs (CVRP) may not be widely implemented...
  30. pmc Interaction of asymmetric ABCC9-encoded nucleotide binding domains determines KATP channel SUR2A catalytic activity
    Sungjo Park
    Marriott Heart Disease Research Program, Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Proteome Res 7:1721-8. 2008
    ....
  31. ncbi request reprint Stable benefit of embryonic stem cell therapy in myocardial infarction
    Denice M Hodgson
    Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Am J Physiol Heart Circ Physiol 287:H471-9. 2004
    ..These findings indicate that embryonic stem cells, through differentiation within the host myocardium, can contribute to a stable beneficial outcome on contractile function and ventricular remodeling in the infarcted heart...

Research Grants4

  1. Regulation of cardiac nuclear pore structure and function
    CARMEN TERZIC; Fiscal Year: 2007
    ..As abnormal function of the nuclear envelope has been linked to a growing number of cardiac congenital defects, this proposal will establish a framework for targeted strategies aimed at supporting reparative cardiogenesis. ..
  2. Regulation of cardiac nuclear pore structure and function
    CARMEN TERZIC; Fiscal Year: 2009
    ..As abnormal function of the nuclear envelope has been linked to a growing number of cardiac congenital defects, this proposal will establish a framework for targeted strategies aimed at supporting reparative cardiogenesis. ..
  3. Regulation of cardiac nuclear pore structure and function
    CARMEN M TERZIC; Fiscal Year: 2010
    ..As abnormal function of the nuclear envelope has been linked to a growing number of cardiac congenital defects, this proposal will establish a framework for targeted strategies aimed at supporting reparative cardiogenesis. ..