Alexander Scott Parker

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. doi request reprint ANKS1B is a smoking-related molecular alteration in clear cell renal cell carcinoma
    Jeanette E Eckel-Passow
    Department of Health Sciences Research, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    BMC Urol 14:14. 2014
  2. pmc Comparison of baseline quality of life measures between renal cell carcinoma patients undergoing partial versus radical nephrectomy
    Michelle L Arnold
    Department of Health Sciences Research, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    BMC Urol 13:52. 2013
  3. doi request reprint Evaluation of B7-H3 expression as a biomarker of biochemical recurrence after salvage radiation therapy for recurrent prostate cancer
    Alexander S Parker
    College of Medicine, Mayo Clinic Florida, Jacksonville, FL 32224, USA
    Int J Radiat Oncol Biol Phys 79:1343-9. 2011
  4. doi request reprint Evaluation of ki-67 staining levels as an independent biomarker of biochemical recurrence after salvage radiation therapy for prostate cancer
    Alexander S Parker
    College of Medicine, Mayo Clinic Florida, Jacksonville, FL 32224, USA
    Int J Radiat Oncol Biol Phys 75:1364-70. 2009
  5. doi request reprint Evaluation of the association of current cigarette smoking and outcome for patients with clear cell renal cell carcinoma
    Alexander Parker
    College of Medicine, Mayo Clinic, Jacksonville, Florida 32224, USA
    Int J Urol 15:304-8. 2008
  6. doi request reprint Evaluation of the impact of body mass index on outcome among renal mass patients treated with hand-assisted laparoscopic radical nephrectomy
    Alexander S Parker
    Department of Urology, Mayo Clinic Jacksonville, Jacksonville, Florida 3222, USA
    J Endourol 22:301-6. 2008
  7. ncbi request reprint Lower expression levels of the transforming growth factor beta receptor type II protein are associated with a less aggressive tumor phenotype and improved survival among patients with clear cell renal cell carcinoma
    Alexander Scott Parker
    Department of Urology, Mayo Clinic, Jacksonville, FL 32224, USA
    Hum Pathol 38:453-61. 2007
  8. ncbi request reprint High expression levels of survivin protein independently predict a poor outcome for patients who undergo surgery for clear cell renal cell carcinoma
    Alexander S Parker
    Department of Urology, Mayo Clinic College of Medicine, Jacksonville, Florida, USA
    Cancer 107:37-45. 2006
  9. ncbi request reprint Gender, alcohol consumption, and renal cell carcinoma
    Alexander S Parker
    Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Am J Epidemiol 155:455-62. 2002
  10. ncbi request reprint Smoking cessation and renal cell carcinoma
    Alexander S Parker
    Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Ann Epidemiol 13:245-51. 2003

Research Grants

Collaborators

Detail Information

Publications25

  1. doi request reprint ANKS1B is a smoking-related molecular alteration in clear cell renal cell carcinoma
    Jeanette E Eckel-Passow
    Department of Health Sciences Research, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    BMC Urol 14:14. 2014
    ..We used a multi-stage design to identify and validate genes that are associated with smoking-related ccRCC...
  2. pmc Comparison of baseline quality of life measures between renal cell carcinoma patients undergoing partial versus radical nephrectomy
    Michelle L Arnold
    Department of Health Sciences Research, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    BMC Urol 13:52. 2013
    ..Previous investigators have compared QoL outcomes for patients undergoing RN and NSS; however, there are limited data comparing QoL-related characteristics at baseline between these groups...
  3. doi request reprint Evaluation of B7-H3 expression as a biomarker of biochemical recurrence after salvage radiation therapy for recurrent prostate cancer
    Alexander S Parker
    College of Medicine, Mayo Clinic Florida, Jacksonville, FL 32224, USA
    Int J Radiat Oncol Biol Phys 79:1343-9. 2011
    ..Related to this, novel targets for adjuvant therapies are also lacking. Here, we evaluate the association of B7-H3 expression in primary PCa tumors and BCR after SRT...
  4. doi request reprint Evaluation of ki-67 staining levels as an independent biomarker of biochemical recurrence after salvage radiation therapy for prostate cancer
    Alexander S Parker
    College of Medicine, Mayo Clinic Florida, Jacksonville, FL 32224, USA
    Int J Radiat Oncol Biol Phys 75:1364-70. 2009
    ..Herein, we evaluate the ability of Ki-67 staining in primary prostate cancer to independently aid in the prediction of BCR among men undergoing SRT...
  5. doi request reprint Evaluation of the association of current cigarette smoking and outcome for patients with clear cell renal cell carcinoma
    Alexander Parker
    College of Medicine, Mayo Clinic, Jacksonville, Florida 32224, USA
    Int J Urol 15:304-8. 2008
    ..Herein, we test the hypothesis that cigarette smoking is associated with a more aggressive phenotype and poorer outcome among patients with RCC...
  6. doi request reprint Evaluation of the impact of body mass index on outcome among renal mass patients treated with hand-assisted laparoscopic radical nephrectomy
    Alexander S Parker
    Department of Urology, Mayo Clinic Jacksonville, Jacksonville, Florida 3222, USA
    J Endourol 22:301-6. 2008
    ..We evaluate whether obese patients undergoing HALRN to manage a renal mass are more likely than nonobese patients to experience poor intraoperative and perioperative outcomes...
  7. ncbi request reprint Lower expression levels of the transforming growth factor beta receptor type II protein are associated with a less aggressive tumor phenotype and improved survival among patients with clear cell renal cell carcinoma
    Alexander Scott Parker
    Department of Urology, Mayo Clinic, Jacksonville, FL 32224, USA
    Hum Pathol 38:453-61. 2007
    ..Data from this investigation are the first to suggest that loss of TbetaRII expression is associated with improved ccRCC patient survival, especially among those patients with less aggressive disease profiles at time of surgery...
  8. ncbi request reprint High expression levels of survivin protein independently predict a poor outcome for patients who undergo surgery for clear cell renal cell carcinoma
    Alexander S Parker
    Department of Urology, Mayo Clinic College of Medicine, Jacksonville, Florida, USA
    Cancer 107:37-45. 2006
    ..What remained in question was whether survivin expression at the protein level is an independent predictor of disease progression and cancer-specific survival...
  9. ncbi request reprint Gender, alcohol consumption, and renal cell carcinoma
    Alexander S Parker
    Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Am J Epidemiol 155:455-62. 2002
    ..These findings suggest an inverse association of alcohol consumption and RCC development among women but not among men...
  10. ncbi request reprint Smoking cessation and renal cell carcinoma
    Alexander S Parker
    Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Ann Epidemiol 13:245-51. 2003
    ..Furthermore, conclusions from previous investigations have been hampered by unstable risk estimates, broad exposure categories and/or insufficient adjustment for the inverse correlation of cessation years with lifetime smoking exposure...
  11. ncbi request reprint Pathologic T1 clear cell renal cell carcinoma: insulin-like growth factor-I receptor expression and disease-specific survival
    Alexander S Parker
    Department of Urology, Mayo College of Medicine, Jacksonville, Florida 32224, USA
    Cancer 100:2577-82. 2004
    ..The authors conducted a case-cohort investigation to examine the association of insulin-like growth factor I receptor (IGF-IR) expression and disease-specific survival in patients who underwent surgery for pT1 CC-RCC...
  12. ncbi request reprint Loss of expression of von Hippel-Lindau tumor suppressor protein associated with improved survival in patients with early-stage clear cell renal cell carcinoma
    Alexander S Parker
    Department of Urology, Mayo Clinic Jacksonville, Jacksonville, Florida 32224, USA
    Urology 65:1090-5. 2005
    ..Recent data have suggested that somatic mutations of the VHL tumor suppressor gene are associated with better cancer-specific survival in patients with CC-RCC...
  13. pmc Development and evaluation of BioScore: a biomarker panel to enhance prognostic algorithms for clear cell renal cell carcinoma
    Alexander S Parker
    Department of Urology, Mayo Medical School, Jacksonville, Florida, USA
    Cancer 115:2092-103. 2009
    ..In the current study, they described the creation of a scoring system based on this panel of biomarkers that can be used in tandem with existing clinicopathologic features and algorithms to improve ccRCC outcome prediction...
  14. ncbi request reprint High expression levels of insulin-like growth factor-I receptor predict poor survival among women with clear-cell renal cell carcinomas
    Alexander S Parker
    Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
    Hum Pathol 33:801-5. 2002
    ....
  15. pmc External validation of IMP3 expression as an independent prognostic marker for metastatic progression and death for patients with clear cell renal cell carcinoma
    Nathan E Hoffmann
    Department of Urology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer 112:1471-9. 2008
    ....
  16. ncbi request reprint Greater body mass index is associated with better pathologic features and improved outcome among patients treated surgically for clear cell renal cell carcinoma
    Alexander S Parker
    Department of Urology, Mayo Clinic Jacksonville, Jacksonville, Florida 32224, USA
    Urology 68:741-6. 2006
    ..We used data from a large cohort of patients treated surgically for clear cell RCC to evaluate the association of obesity with the pathologic features of tumor aggressiveness and cancer-specific outcomes...
  17. pmc Comparison of digital image analysis versus visual assessment to assess survivin expression as an independent predictor of survival for patients with clear cell renal cell carcinoma
    Alexander S Parker
    Department of Urology, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Hum Pathol 39:1176-84. 2008
    ..Thus, visual assessment represents an economical, widely available, and reliable method to assess survivin as a predictor of clear cell renal cell carcinoma patient outcomes...
  18. ncbi request reprint Prediction of progression after radical nephrectomy for patients with clear cell renal cell carcinoma: a stratification tool for prospective clinical trials
    Bradley C Leibovich
    Department of Urology, Mayo Medical School and Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer 97:1663-71. 2003
    ....
  19. ncbi request reprint History of urinary tract infection and risk of renal cell carcinoma
    Alexander S Parker
    Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
    Am J Epidemiol 159:42-8. 2004
    ..Results suggest a positive association of UTI history with RCC development, with elevated risks most notable for males with a history of smoking...
  20. ncbi request reprint Salvage radiotherapy for isolated prostate specific antigen increase after radical prostatectomy: evaluation of prognostic factors and creation of a prognostic scoring system
    Steven J Buskirk
    Department of Radiation Oncology, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    J Urol 176:985-90. 2006
    ..This study was performed to evaluate the results and prognostic factors associated with radiotherapy for a detectable serum prostate specific antigen level after radical prostatectomy...
  21. ncbi request reprint Survivin and b7-h1 are collaborative predictors of survival and represent potential therapeutic targets for patients with renal cell carcinoma
    Amy E Krambeck
    Department of Urology, Mayo Medical School, Mayo Clinic, Rochester, MN 55905, USA
    Clin Cancer Res 13:1749-56. 2007
    ..Herein, we examine the clinical effect of ccRCC combined expression of both survivin and B7-H1...
  22. ncbi request reprint Clear cell renal cell carcinoma: gene expression analyses identify a potential signature for tumor aggressiveness
    Farhad Kosari
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Clin Cancer Res 11:5128-39. 2005
    ..The objective of this study was to use gene expression profiling to identify novel biomarkers that are predictive of aggressive behavior in clear cell renal cell carcinoma (CCRCC)...
  23. ncbi request reprint Tumor B7-H1 is associated with poor prognosis in renal cell carcinoma patients with long-term follow-up
    R Houston Thompson
    Department of Urology, Mayo Medical School, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Cancer Res 66:3381-5. 2006
    ..RCC patients with tumor B7-H1 are at significant risk of rapid cancer progression and accelerated rates of mortality. B7-H1 may function as a key determinant in RCC, abrogating immune responses directed against this immunogenic tumor...
  24. ncbi request reprint Secreted frizzled-related protein 1 loss contributes to tumor phenotype of clear cell renal cell carcinoma
    Michelle L Gumz
    Department of Cancer Biology, Mayo Clinic Jacksonville, Florida 32224, USA
    Clin Cancer Res 13:4740-9. 2007
    ..In an effort to gain a better understanding of signaling events in clear cell RCC (cRCC), we investigated the antitumor activity of secreted frizzled-related protein 1 (sFRP1), a negative regulator of Wnt signaling...
  25. pmc A p120 catenin isoform switch affects Rho activity, induces tumor cell invasion, and predicts metastatic disease
    Masahiro Yanagisawa
    Department of Cancer Biology, Mayo Clinic, Jacksonville, FL 32224, USA
    J Biol Chem 283:18344-54. 2008
    ..The data indicate that the increased expression of p120 isoform 1 during tumor progression contributes to the invasive phenotype of cadherin-deficient carcinomas and that the N-terminal domain of p120 is a valid therapeutic target...

Research Grants3

  1. Differential Gene Expression in Renal Cancers
    Alexander Parker; Fiscal Year: 2003
    ..The long-term goal of the proposed study is to potentially inform novel prevention and treatment strategies for RCC at both the individual and population level. ..
  2. Type II TGF Beta Receptor and RCC Progression
    Alexander Parker; Fiscal Year: 2007
    ..In summary, we will evaluate an innovative translational hypothesis regarding molecular determinants of RCC progression in order to better understand the pathogenesis of this disease and potentially inform on novel treatment regimens. ..
  3. Design and Validation of a Biomarker-enhanced System to Predict RCC Progression
    Alexander S Parker; Fiscal Year: 2010
    ....