V Shane Pankratz

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Replication of EPHA1 and CD33 associations with late-onset Alzheimer's disease: a multi-centre case-control study
    Minerva M Carrasquillo
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Mol Neurodegener 6:54. 2011
  2. pmc No evidence for association of inherited variation in genes involved in mitosis and percent mammographic density
    Celine M Vachon
    Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Breast Cancer Res 14:R7. 2012
  3. pmc Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers
    Antonis C Antoniou
    Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Worts Causeway, Cambridge CB1 8RN, UK
    Breast Cancer Res 14:R33. 2012
  4. pmc Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications
    Mariet Allen
    Mayo Clinic Florida, Department of Neuroscience, Jacksonville, FL, USA
    Mol Neurodegener 7:13. 2012
  5. pmc Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2
    Anna Marie Mulligan
    Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, 2 Worts Causeway, Cambridge, CB1 8RN, UK
    Breast Cancer Res 13:R110. 2011
  6. pmc Evidence for SMAD3 as a modifier of breast cancer risk in BRCA2 mutation carriers
    Logan C Walker
    Division of Genetics and Population Health, Queensland Institute of Medical Research, Brisbane, Australia
    Breast Cancer Res 12:R102. 2010
  7. pmc Genetic variation in stromal proteins decorin and lumican with breast cancer: investigations in two case-control studies
    Linda E Kelemen
    Department of Population Health Research, Alberta Cancer Board, 1331 29th Street NW, Calgary, AB T2N 4N2, Canada
    Breast Cancer Res 10:R98. 2008
  8. pmc Mammographic density, breast cancer risk and risk prediction
    Celine M Vachon
    Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Breast Cancer Res 9:217. 2007
  9. pmc Linkage analysis of obesity phenotypes in pre- and post-menopausal women from a United States mid-western population
    Linda E Kelemen
    Department of Population Health Research, Alberta Health Services Cancer Care, Calgary, AB, Canada
    BMC Med Genet 11:156. 2010
  10. ncbi request reprint Random-effects Cox proportional hazards model: general variance components methods for time-to-event data
    V Shane Pankratz
    Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA
    Genet Epidemiol 28:97-109. 2005

Detail Information

Publications127 found, 100 shown here

  1. pmc Replication of EPHA1 and CD33 associations with late-onset Alzheimer's disease: a multi-centre case-control study
    Minerva M Carrasquillo
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Mol Neurodegener 6:54. 2011
    ..abstract:..
  2. pmc No evidence for association of inherited variation in genes involved in mitosis and percent mammographic density
    Celine M Vachon
    Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Breast Cancer Res 14:R7. 2012
    ....
  3. pmc Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers
    Antonis C Antoniou
    Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Worts Causeway, Cambridge CB1 8RN, UK
    Breast Cancer Res 14:R33. 2012
    ..2)...
  4. pmc Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications
    Mariet Allen
    Mayo Clinic Florida, Department of Neuroscience, Jacksonville, FL, USA
    Mol Neurodegener 7:13. 2012
    ..4,617 controls) and PD (678 PDs vs. 712 controls) for association with disease risk (case-controls), age-at-diagnosis (cases) and brain gene expression levels (autopsied subjects)...
  5. pmc Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2
    Anna Marie Mulligan
    Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, 2 Worts Causeway, Cambridge, CB1 8RN, UK
    Breast Cancer Res 13:R110. 2011
    ..It is currently unknown how these alleles are associated with different breast cancer subtypes in BRCA1 and BRCA2 mutation carriers defined by estrogen (ER) or progesterone receptor (PR) status of the tumour...
  6. pmc Evidence for SMAD3 as a modifier of breast cancer risk in BRCA2 mutation carriers
    Logan C Walker
    Division of Genetics and Population Health, Queensland Institute of Medical Research, Brisbane, Australia
    Breast Cancer Res 12:R102. 2010
    ..In this study, we evaluated 24 SNPs tagged to 14 candidate genes derived through a novel approach that analysed gene expression differences to prioritise candidate modifier genes for association studies...
  7. pmc Genetic variation in stromal proteins decorin and lumican with breast cancer: investigations in two case-control studies
    Linda E Kelemen
    Department of Population Health Research, Alberta Cancer Board, 1331 29th Street NW, Calgary, AB T2N 4N2, Canada
    Breast Cancer Res 10:R98. 2008
    ..Altered expression of decorin and lumican is associated with breast tumors. We hypothesized that genetic variation in the decorin (DCN) and lumican (LUM) genes may contribute to breast cancer...
  8. pmc Mammographic density, breast cancer risk and risk prediction
    Celine M Vachon
    Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Breast Cancer Res 9:217. 2007
    ..Promising new measures of mammographic density, including volumetric density, which can be standardized using full-field digital mammography, will likely result in a stronger risk factor and improve accuracy of risk prediction models...
  9. pmc Linkage analysis of obesity phenotypes in pre- and post-menopausal women from a United States mid-western population
    Linda E Kelemen
    Department of Population Health Research, Alberta Health Services Cancer Care, Calgary, AB, Canada
    BMC Med Genet 11:156. 2010
    ..Women are also more likely to distribute weight in the abdomen following menopause. We investigated whether genetic loci link with obesity-related phenotypes differently by menopausal status...
  10. ncbi request reprint Random-effects Cox proportional hazards model: general variance components methods for time-to-event data
    V Shane Pankratz
    Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA
    Genet Epidemiol 28:97-109. 2005
    ..The methods outlined here make it possible to perform general variance components analyses on time-to-event endpoints, even on large data sets, in a computationally efficient manner...
  11. pmc Associations between SNPs in candidate immune-relevant genes and rubella antibody levels: a multigenic assessment
    V Shane Pankratz
    Division of Biomedical Statistics and Informatics, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA
    BMC Immunol 11:48. 2010
    ..Associations between rubella-specific antibody levels and 726 candidate tagSNPs were assessed both one SNP at a time and in a variety of multigenic analyses...
  12. pmc Human leukocyte antigen and interleukin 2, 10 and 12p40 cytokine responses to measles: is there evidence of the HLA effect?
    Inna G Ovsyannikova
    Mayo Clinic Vaccine Research Group, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Cytokine 36:173-9. 2006
    ..These novel findings suggest that HLA class II genes may influence the level of cytokine production in the adaptive immune responses to measles vaccine...
  13. pmc Influence of host genetic variation on rubella-specific T cell cytokine responses following rubella vaccination
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
    Vaccine 27:3359-66. 2009
    ....
  14. pmc Association between mammographic density and age-related lobular involution of the breast
    Karthik Ghosh
    Division of General Internal Medicine, Department of Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    J Clin Oncol 28:2207-12. 2010
    ..We examined the involution and density association in a large benign breast disease (BBD) cohort...
  15. pmc HLA haplotype and supertype associations with cellular immune responses and cytokine production in healthy children after rubella vaccine
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
    Vaccine 27:3349-58. 2009
    ....
  16. pmc Extended LTA, TNF, LST1 and HLA gene haplotypes and their association with rubella vaccine-induced immunity
    Inna G Ovsyannikova
    Vaccine Research Group, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 5:e11806. 2010
    ..Apart from HLA, little is known about the effect of this extended genetic region on HLA haplotypic backgrounds as applied to immune responses...
  17. ncbi request reprint Extinction of the human leukocyte antigen homozygosity effect after two doses of the measles-mumps-rubella vaccine
    Jennifer L St Sauver
    Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester, MN 55905, USA
    Hum Immunol 66:788-98. 2005
    ..However, children who are HLA homozygous may be less protected against mumps compared with children who are heterozygous...
  18. pmc Novel breast tissue feature strongly associated with risk of breast cancer
    Kevin P McKian
    Department of Oncology, Mayo Clinic Cancer Center, Mayo Graduate School of Medical Education, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Clin Oncol 27:5893-8. 2009
    ..Breast lobules are the anatomic sites of origin of breast cancer. As women age, these lobular structures should regress, which results in reduced breast cancer risk. However, this does not occur in all women...
  19. ncbi request reprint A comprehensive examination of CYP19 variation and breast density
    Janet E Olson
    Division of Epidemiology, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, MN 55901, USA
    Cancer Epidemiol Biomarkers Prev 16:623-5. 2007
  20. pmc Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk
    Ellen L Goode
    Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 18:935-44. 2009
    ..These results exemplify the utility of imputation in candidate gene studies and lend evidence to a role of cell cycle genes in ovarian cancer etiology, suggest a reduced set of SNPs to target in additional cases and controls...
  21. ncbi request reprint Longitudinal trends in mammographic percent density and breast cancer risk
    Celine M Vachon
    Mayo Clinic College of Medicine, Charlton 6 239, 200 First Street Southwest, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 16:921-8. 2007
    ..Mammographic density is a strong risk factor for breast cancer. However, whether changes in mammographic density are associated with risk remains unclear...
  22. pmc Association of prior stroke with cognitive function and cognitive impairment: a population-based study
    David S Knopman
    Department of Neurology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Arch Neurol 66:614-9. 2009
    ..Defining the nature of the contribution of stroke to cognitive impairment remains challenging...
  23. pmc Independent association of lobular involution and mammographic breast density with breast cancer risk
    Karthik Ghosh
    Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Natl Cancer Inst 102:1716-23. 2010
    ..Lobular involution, or age-related atrophy of breast lobules, is inversely associated with breast cancer risk, and mammographic breast density (MBD) is positively associated with breast cancer risk...
  24. pmc Physical exercise, aging, and mild cognitive impairment: a population-based study
    Yonas E Geda
    Mayo Clinic, 200 First Street SW, Rochester, MN 55905
    Arch Neurol 67:80-6. 2010
    ..Physical exercise is associated with decreased risk of dementia and Alzheimer disease...
  25. pmc Human leukocyte antigen and cytokine receptor gene polymorphisms associated with heterogeneous immune responses to mumps viral vaccine
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Pediatrics 121:e1091-9. 2008
    ..We set out to assess whether HLA and cytokine gene polymorphisms are associated with variations in the immune response to mumps viral vaccine...
  26. pmc Impact of cytokine and cytokine receptor gene polymorphisms on cellular immunity after smallpox vaccination
    Inna G Ovsyannikova
    Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
    Gene 510:59-65. 2012
    ..009 for Caucasians and p=0.01 for African-Americans). Our results demonstrate that variations in smallpox vaccine-induced cytokine responses are modulated by genetic polymorphisms in cytokine and cytokine receptor genes...
  27. pmc Association of genetic variation in mitotic kinases with breast cancer risk
    Xianshu Wang
    Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Breast Cancer Res Treat 119:453-62. 2010
    ..006) genes. Although requiring replication, these findings suggest that genetic polymorphisms in mitotic kinases that have been implicated in chromosome instability and aneuploidy may contribute to the development of breast cancer...
  28. pmc The Mayo Clinic Study of Aging: design and sampling, participation, baseline measures and sample characteristics
    Rosebud O Roberts
    Division of Epidemiology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Neuroepidemiology 30:58-69. 2008
    ..The objective of this study was to establish a prospective population-based cohort to investigate the prevalence, incidence and risk factors for mild cognitive impairment (MCI) and dementia...
  29. pmc Vegetables, unsaturated fats, moderate alcohol intake, and mild cognitive impairment
    Rosebud O Roberts
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA roberts rosebud mayo edu
    Dement Geriatr Cogn Disord 29:413-23. 2010
    ..To investigate associations of the Mediterranean diet (MeDi) components and the MeDi score with mild cognitive impairment (MCI)...
  30. ncbi request reprint Methylenetetrahydrofolate reductase haplotype tag single-nucleotide polymorphisms and risk of breast cancer
    Yvette N Martin
    Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 15:2322-4. 2006
  31. ncbi request reprint HLA homozygosity does not adversely affect measles vaccine-induced cytokine responses
    Inna G Ovsyannikova
    Mayo Clinic Vaccine Research Group, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Virology 364:87-94. 2007
    ..01). Our results suggest that HLA homozygosity showed no disadvantage for measles-specific cytokine responses and instead was associated with increased IFN-gamma levels...
  32. pmc 2'-5'-Oligoadenylate synthetase single-nucleotide polymorphisms and haplotypes are associated with variations in immune responses to rubella vaccine
    Iana H Haralambieva
    Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN, USA
    Hum Immunol 71:383-91. 2010
    ..Our results suggest that innate immunity and OAS genetic variations are likely involved in modulating the magnitude and quality of the adaptive immune responses to live attenuated rubella vaccine...
  33. pmc Evaluation of associations between common variation in mitotic regulatory pathways and risk of overall and high grade breast cancer
    Kristen N Stevens
    Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Breast Cancer Res Treat 129:617-22. 2011
    ..Further investigation in breast and other cancers are needed to understand the influence of inherited variation in mitotic genes on tumor grade and cancer risk...
  34. doi request reprint The role of polymorphisms in Toll-like receptors and their associated intracellular signaling genes in measles vaccine immunity
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic, Guggenheim 611C, 200 1st Street S W, Rochester, MN 55905, USA
    Hum Genet 130:547-61. 2011
    ..These data help to establish the genetic foundation for immune response variation in response to measles immunization and provide important insights for the rational development of new measles vaccines...
  35. pmc Associations between SNPs in toll-like receptors and related intracellular signaling molecules and immune responses to measles vaccine: preliminary results
    Neelam Dhiman
    Mayo Vaccine Research Group, Mayo Clinic, Guggenheim 611C, 200 First Street SW, Rochester, MN 55905, USA
    Vaccine 26:1731-6. 2008
    ..These data contribute to understanding the immunogenetic mechanisms underlying variations in the immune response to measles vaccine...
  36. pmc Association of genetic variation in genes implicated in the beta-catenin destruction complex with risk of breast cancer
    Xianshu Wang
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Stabile 2 42, 200 First Street Southwest, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 17:2101-8. 2008
    ....
  37. pmc Association of C-reactive protein with mild cognitive impairment
    Rosebud O Roberts
    Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, MN, USA
    Alzheimers Dement 5:398-405. 2009
    ..This study examined the association of inflammatory markers in serum or plasma with prevalent MCI and MCI subtypes in a population-based sample...
  38. ncbi request reprint Human leukocyte antigen haplotypes in the genetic control of immune response to measles-mumps-rubella vaccine
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Infect Dis 193:655-63. 2006
    ..002). Better characterization of such HLA profiles could inform and improve the design of novel epitope-rich vaccines and help to predict protective immune responses at the individual and population level...
  39. ncbi request reprint Age-related lobular involution and risk of breast cancer
    Tia R Milanese
    Mayo Medical School, Rochester, MN 55905, USA
    J Natl Cancer Inst 98:1600-7. 2006
    ..As women age, the lobules in their breasts undergo involution or regression. We investigated whether lobular involution in women with benign breast disease was associated with subsequent breast cancer risk...
  40. pmc Human leukocyte antigens and cellular immune responses to anthrax vaccine adsorbed
    Inna G Ovsyannikova
    Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, Minnesota, USA
    Infect Immun 81:2584-91. 2013
    ....
  41. pmc Cardiac disease associated with increased risk of nonamnestic cognitive impairment: stronger effect on women
    Rosebud O Roberts
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    JAMA Neurol 70:374-82. 2013
    ..Nonamnestic mild cognitive impairment, a putative precursor of vascular and other non-Alzheimer dementias, is hypothesized to have a vascular etiology...
  42. pmc Relative intake of macronutrients impacts risk of mild cognitive impairment or dementia
    Rosebud O Roberts
    Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA
    J Alzheimers Dis 32:329-39. 2012
    ..52-1.20]; p for trend = 0.03) in the fully adjusted models. A dietary pattern with relatively high caloric intake from carbohydrates and low caloric intake from fat and proteins may increase the risk of MCI or dementia in elderly persons...
  43. pmc A novel automated mammographic density measure and breast cancer risk
    John J Heine
    Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    J Natl Cancer Inst 104:1028-37. 2012
    ..We developed an automated and objective measurement of the grayscale value variation within a mammogram, evaluated its association with breast cancer, and compared its performance with that of percent density (PD)...
  44. pmc Associations between demographic variables and multiple measles-specific innate and cell-mediated immune responses after measles vaccination
    Benjamin J Umlauf
    Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, Minnesota 55905, USA
    Viral Immunol 25:29-36. 2012
    ..These data further advance our understanding regarding inter-individual and subgroup variations in immune responses to measles vaccination...
  45. ncbi request reprint Variations in measles vaccine-specific humoral immunity by polymorphisms in SLAM and CD46 measles virus receptors
    Neelam Dhiman
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, Minn, USA
    J Allergy Clin Immunol 120:666-72. 2007
    ..Measles infection requires 2 cellular receptors, signaling lymphocyte activation molecule (SLAM) and CD46. Known and novel single nucleotide polymorphisms (SNPs) in SLAM and CD46 genes might influence the immune response to measles vaccine...
  46. pmc Pseudoangiomatous stromal hyperplasia and breast cancer risk
    Amy C Degnim
    Department of Surgery, Mayo Clinic, Rochester, MN, USA
    Ann Surg Oncol 17:3269-77. 2010
    ..Pseudoangiomatous stromal hyperplasia (PASH) is a benign localized fibrotic lesion in which clusters of spindle cells form cleftlike spaces, resembling ectatic vessels. Its relationship to breast cancer risk has not been characterized...
  47. doi request reprint Age-specific trends in mammographic density: the Minnesota Breast Cancer Family Study
    Linda E Kelemen
    Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Am J Epidemiol 167:1027-36. 2008
    ..These data suggest that menopause, baseline PD, postmenopausal hormone use, and body mass index predict changes in mammographic density trends during adult life...
  48. pmc Evaluation of the Tyrer-Cuzick (International Breast Cancer Intervention Study) model for breast cancer risk prediction in women with atypical hyperplasia
    Judy C Boughey
    Mayo Clinic, Rochester, MN 55905, USA
    J Clin Oncol 28:3591-6. 2010
    ..We evaluated the performance of the Tyrer-Cuzick model, which was designed to predict 10-year risk of breast cancer development, in a well-defined cohort of women with atypia...
  49. ncbi request reprint HLA supertypes and immune responses to measles-mumps-rubella viral vaccine: findings and implications for vaccine design
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Vaccine 25:3090-100. 2007
    ..This information may be of significant value in the engineering of potential epitope-based vaccines that are recognized by T cells restricted by human HLA supertype alleles...
  50. pmc Association of mammographic density with the pathology of subsequent breast cancer among postmenopausal women
    Karthik Ghosh
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 17:872-9. 2008
    ..Limited studies have examined the associations between mammographic density and subsequent breast tumor characteristics...
  51. doi request reprint Breast cancer risk in women with radial scars in benign breast biopsies
    Jena C Berg
    Department of Laboratory Medicine and Pathology, Division of Anatomic Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Breast Cancer Res Treat 108:167-74. 2008
    ..We studied the relative risk of radial scar lesions in a large cohort of patients with benign breast disease (BBD)...
  52. ncbi request reprint Severity of childhood asthma and human leukocyte antigens type
    Young J Juhn
    Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Asthma 44:163-8. 2007
    ..Because of limited statistical power, our study findings are subject to further investigation...
  53. pmc Polyunsaturated fatty acids and reduced odds of MCI: the Mayo Clinic Study of Aging
    Rosebud O Roberts
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
    J Alzheimers Dis 21:853-65. 2010
    ..In this study, higher intake of PUFA and MUFA was associated with a reduced likelihood of MCI among elderly persons in the population-based setting...
  54. pmc Texture features from mammographic images and risk of breast cancer
    Armando Manduca
    Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 1st Street Southwest, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 18:837-45. 2009
    ..However, simultaneous inclusion of these features in a model with PD did not significantly improve the ability to predict breast cancer...
  55. ncbi request reprint Immunologic significance of HLA class I genes in measles virus-specific IFN-gamma and IL-4 cytokine immune responses
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Immunogenetics 57:828-36. 2005
    ..Understanding the genetic factors that influence variations in cytokine secretion following measles vaccination will provide insight into the factors that influence both cell-mediated and humoral immunity to measles...
  56. pmc Assessment of the accuracy of the Gail model in women with atypical hyperplasia
    V Shane Pankratz
    Division of Biostatistics, Medical Oncology, General Surgery, Internal Medicine, Epidemiology, and Anatomic Pathology, Mayo Clinic, Rochester, MN 55905, USA
    J Clin Oncol 26:5374-9. 2008
    ..Women with biopsy-confirmed atypical hyperplasia of the breast (atypia) are at high risk for breast cancer. The Gail model is widely used in these women, but has not been validated in them...
  57. ncbi request reprint Human leukocyte antigen class II alleles and rubella-specific humoral and cell-mediated immunity following measles-mumps-rubella-II vaccination
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Infect Dis 191:515-9. 2005
    ..This study of HLA class II-restricted humoral and cellular immune responses to rubella provides significant insight into mechanisms of vaccine response and new vaccine development...
  58. ncbi request reprint Associations between measles vaccine immunity and single-nucleotide polymorphisms in cytokine and cytokine receptor genes
    Neelam Dhiman
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
    J Infect Dis 195:21-9. 2007
    ..Cytokines are key regulators of measles vaccine humoral and cellular immunity. Single-nucleotide polymorphisms (SNPs) that are associated with differences in cytokine levels should also influence measles vaccine-induced immunity...
  59. pmc Computer activities, physical exercise, aging, and mild cognitive impairment: a population-based study
    Yonas E Geda
    Department of Psychiatry and Psychology, Mayo Clinic, Scottsdale, AZ 85259, USA
    Mayo Clin Proc 87:437-42. 2012
    ..To examine the association between computer use, physical exercise, aging, and mild cognitive impairment (MCI)...
  60. pmc Correlations between vaccinia-specific immune responses within a cohort of armed forces members
    Benjamin J Umlauf
    Vaccine Research Group, Mayo Clinic, Rochester, Minnesota 55905, USA
    Viral Immunol 24:415-20. 2011
    ....
  61. pmc Common variants associated with breast cancer in genome-wide association studies are modifiers of breast cancer risk in BRCA1 and BRCA2 mutation carriers
    Xianshu Wang
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
    Hum Mol Genet 19:2886-97. 2010
    ..Upon further validation, these SNPs together with other genetic and environmental factors may improve breast cancer risk assessment in these populations...
  62. pmc Predominant inflammatory cytokine secretion pattern in response to two doses of live rubella vaccine in healthy vaccinees
    Neelam Dhiman
    Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Cytokine 50:24-9. 2010
    ..These results suggest an immune-deviation or "skewing" from Th1/Th2 cytokine patterns towards a predominant inflammatory response upon in vitro rubella virus stimulation...
  63. pmc Polymorphisms in the vitamin A receptor and innate immunity genes influence the antibody response to rubella vaccination
    Inna G Ovsyannikova
    Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Infect Dis 201:207-13. 2010
    ..Genetic polymorphisms play an important role in rubella vaccine-induced immunity...
  64. pmc Common SNPs/haplotypes in IL18R1 and IL18 genes are associated with variations in humoral immunity to smallpox vaccination in Caucasians and African Americans
    Iana H Haralambieva
    Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Infect Dis 204:433-41. 2011
    ..Identifying genetic factors that influence poxvirus immunity across races may assist in the development of better vaccines and approaches for vaccine development...
  65. pmc Engaging in cognitive activities, aging, and mild cognitive impairment: a population-based study
    Yonas E Geda
    Department of Health Sciences Research, Divisions of Epidemiology, College of Medicine, Mayo Clinic, Rochester MN, Wheaton University Topazian, Chicago IL, USA
    J Neuropsychiatry Clin Neurosci 23:149-54. 2011
    ..The equally high prevalence of reading newspapers in both groups yielded no significant between-group difference...
  66. ncbi request reprint Analysis of hypocretin (orexin) antibodies in patients with narcolepsy
    John L Black
    Psychogenomics Laboratory, Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, MN, USA
    Sleep 28:427-31. 2005
    ..We tested the hypothesis that patients with narcolepsy have serum antibodies specific for preprohypocretin and its derivatives...
  67. pmc Polymorphisms in NF-kappaB inhibitors and risk of epithelial ovarian cancer
    Kristin L White
    Mayo Clinic College of Medicine, Rochester, MN, USA
    BMC Cancer 9:170. 2009
    ..Inhibitors of kappaB (IkappaB) prevent NF-kappaB activation by sequestering NF-kappaB proteins in the cytoplasm until IkappaB proteins are phosphorylated and degraded...
  68. pmc Associations between single nucleotide polymorphisms and haplotypes in cytokine and cytokine receptor genes and immunity to measles vaccination
    Iana H Haralambieva
    Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
    Vaccine 29:7883-95. 2011
    ..003). Our results validate previous findings and identify new plausible genetic determinants, including IL7R polymorphisms, regulating measles vaccine-induced immunity in a race-specific manner...
  69. ncbi request reprint Depression, apolipoprotein E genotype, and the incidence of mild cognitive impairment: a prospective cohort study
    Yonas E Geda
    Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn, USA
    Arch Neurol 63:435-40. 2006
    ..It remains unknown whether depression and apolipoprotein E genotype are risk factors for incident mild cognitive impairment (MCI)...
  70. pmc Validation of the telephone interview for cognitive status-modified in subjects with normal cognition, mild cognitive impairment, or dementia
    David S Knopman
    Department of Neurology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Neuroepidemiology 34:34-42. 2010
    ..The telephone assessment of cognitive functions may reduce the cost and burden of epidemiological studies...
  71. ncbi request reprint The association of class I HLA alleles and antibody levels after a single dose of measles vaccine
    Robert M Jacobson
    Department of Pediatric and Adolescent MedicineMayo Clinic, Rochester, MN 55903, USA
    Hum Immunol 64:103-9. 2003
    ....
  72. ncbi request reprint Stratification of breast cancer risk in women with atypia: a Mayo cohort study
    Amy C Degnim
    Division of General Surgery, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Clin Oncol 25:2671-7. 2007
    ..Atypical hyperplasia is a well-recognized risk factor for breast cancer, conveying an approximately four-fold increased risk. Data regarding long-term absolute risk and factors for risk stratification are needed...
  73. pmc Association of duration and severity of diabetes mellitus with mild cognitive impairment
    Rosebud O Roberts
    Department of Health Sciences Research, Division of Epidemiology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Arch Neurol 65:1066-73. 2008
    ..It remains unknown whether diabetes mellitus (DM) is a risk factor for mild cognitive impairment (MCI)...
  74. pmc Performance of amplified DNA in an Illumina GoldenGate BeadArray assay
    Julie M Cunningham
    Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 17:1781-9. 2008
    ..We recommend that biological SNP characteristics, notably distance to telomere and GC content (<50% GC recommended), as well as Illumina-provided metrics be considered in the creation of GoldenGate assays using MDA WGA DNA...
  75. pmc Genetic variants and risk of lung cancer in never smokers: a genome-wide association study
    Yafei Li
    Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Lancet Oncol 11:321-30. 2010
    ..Lung cancer in individuals who have never smoked tobacco products is an increasing medical and public-health issue. We aimed to unravel the genetic basis of lung cancer in never smokers...
  76. ncbi request reprint HLA class II alleles and measles virus-specific cytokine immune response following two doses of measles vaccine
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic and Foundation, Guggenheim 611C, 200 1st Street SW, Rochester, MN 55905, USA
    Immunogenetics 56:798-807. 2005
    ..These data suggest that IFN-gamma and IL-4 cytokine responses to measles may be genetically restricted in part by HLA class II genes, which in turn can restrict the cellular immune response to measles vaccine...
  77. pmc Aromatase immunoreactivity is increased in mammographically dense regions of the breast
    Celine M Vachon
    Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Breast Cancer Res Treat 125:243-52. 2011
    ..45, SD = 0.39) breast tissue (β(H) = 0.45; P < 0.001). Overall, aromatase IR was greater for mammographically dense versus non-dense tissue and may partly explain how MBD influences breast cancer...
  78. ncbi request reprint Strong evidence of a genetic determinant for mammographic density, a major risk factor for breast cancer
    Celine M Vachon
    Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Cancer Res 67:8412-8. 2007
    ..4 cM). The putative locus on chromosome 5p is likely to account for up to 22% of variation in MD. Hence, 1 or more of the 45 candidate genes in this region could explain a large proportion of MD and, potentially, breast cancer...
  79. pmc AURKA F31I polymorphism and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a consortium of investigators of modifiers of BRCA1/2 study
    Fergus J Couch
    Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 16:1416-21. 2007
    ..In summary, the F31I polymorphism in AURKA is not associated with a modified risk of breast cancer in BRCA1 and BRCA2 carriers...
  80. pmc Response surface methodology to determine optimal cytokine responses in human peripheral blood mononuclear cells after smallpox vaccination
    Jenna E Ryan
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, United States
    J Immunol Methods 341:97-105. 2009
    ..The use of the response surface methodology can be applied to the optimization of other laboratory assays; especially when the number of PBMC available limits the testing of all possible combinations of parameters...
  81. ncbi request reprint The contribution of HLA class I antigens in immune status following two doses of rubella vaccination
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Hum Immunol 65:1506-15. 2004
    ..These data may facilitate our understanding of immune response variation in a genetically outbred heterogeneous population...
  82. ncbi request reprint Benign breast disease and the risk of breast cancer
    Lynn C Hartmann
    Division of Medical Oncology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    N Engl J Med 353:229-37. 2005
    ..Benign breast disease is an important risk factor for breast cancer. We studied a large group of women with benign breast disease to obtain reliable estimates of this risk...
  83. pmc Replication of CLU, CR1, and PICALM associations with alzheimer disease
    Minerva M Carrasquillo
    Department of Neuroscience, Mayo Clinic, 4500 San Pablo Rd, Birdsall Building, Jacksonville, FL 32224, USA
    Arch Neurol 67:961-4. 2010
    ..To test for replication of the association between variants in the CLU, CR1, and PICALM genes with Alzheimer disease...
  84. ncbi request reprint The lifetime risk of suicide in schizophrenia: a reexamination
    Brian A Palmer
    Mayo Medical School, Department of Health Sciences Research, Rochester, Minn, USA
    Arch Gen Psychiatry 62:247-53. 2005
    ..The psychiatry literature routinely quotes a lifetime schizophrenia suicide prevalence of 10% based on 1 meta-analysis and 2 studies of chronic schizophrenics...
  85. ncbi request reprint Canine red blood cell thiopurine S-methyltransferase: companion animal pharmacogenetics
    Oreste E Salavaggione
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Medical School Mayo Clinic Mayo Foundation, Rochester, Minnesota 55905, USA
    Pharmacogenetics 12:713-24. 2002
    ..These observations represent a step towards the application of pharmacogenetic and pharmacogenomic principles to companion animal drug therapy...
  86. ncbi request reprint Confrontation naming does not add incremental diagnostic utility in MCI and Alzheimer's disease
    Julie A Testa
    Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota 55901, USA
    J Int Neuropsychol Soc 10:504-12. 2004
    ..Collectively these results suggest that although BNT impairments become more common as AD progresses, they are neither necessary for the diagnosis of AD nor particularly useful in identifying early AD...
  87. ncbi request reprint Decisional capacity of severely depressed patients requiring electroconvulsive therapy
    Maria I Lapid
    Department of Psychiatry and Psychology and dagger Department of Biostatistics, Mayo Clinic, Rochester, Minnesota, USA
    J ECT 19:67-72. 2003
    ..Our study aimed to determine the decisional capacity of severely depressed people requiring electroconvulsive therapy (ECT), and whether educational interventions improve their ability to provide informed consent for ECT...
  88. ncbi request reprint A multidimensional workshop using human cadavers to teach bedside procedures
    Amy S Oxentenko
    Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Teach Learn Med 15:127-30. 2003
    ..Internal medicine residents should be able to perform bedside procedures safely and efficiently...
  89. pmc Rates of brain atrophy over time in autopsy-proven frontotemporal dementia and Alzheimer disease
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
    Neuroimage 39:1034-40. 2008
    ..The trajectories of brain and ventricular changes were similar in AD and FTLD-U suggesting that it is independent of pathology, although subjects with FTLD-U show a more rapidly progressive decline...
  90. ncbi request reprint Primary pulmonary carcinoma in patients with idiopathic pulmonary fibrosis
    Marie Christine Aubry
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minn 55905, USA
    Mayo Clin Proc 77:763-70. 2002
    ..To identify distinguishing characteristics between patients with idiopathic pulmonary fibrosis (IPF) and primary lung carcinoma and patients with either IPF or carcinoma alone...
  91. ncbi request reprint Women with diabetes have poorer control of blood pressure than men
    Murali K Duggirala
    Division of General Internal Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota 55901, USA
    J Womens Health (Larchmt) 14:418-23. 2005
    ..Less aggressive control of the CHD risk factors in women can contribute to this excess mortality. Because hypertension has a high prevalence in subjects with diabetes, we compared the control of this risk factor between men and women...
  92. ncbi request reprint Hypocretin (orexin) levels in cerebrospinal fluid of patients with narcolepsy: relationship to cataplexy and HLA DQB1*0602 status
    Lois E Krahn
    Mayo Clinic, Department of Psychiatry and Psychology, Rochester, MN 55905, USA
    Sleep 25:733-6. 2002
    ..5%) and more specifically with patients with cataplexy who are HLA DQB1*0602 positive (95.7%). The relationship between hypocretin-1 levels and narcolepsy without cataplexy or the DQB1*0602 allele is less clear...
  93. ncbi request reprint Depression coping self-efficacy as a predictor of relapse 1 and 2 years following psychiatric hospital-based treatment
    Sharon Tucker
    Department of Nursing, Mayo Clinic, Rochester, MN 55905, USA
    Res Theory Nurs Pract 18:261-75. 2004
    ..Two-year findings did not differ based on original treatment type. Findings support further research examining the DCSES as a predictor of relapse and a target for treatment...
  94. ncbi request reprint Prospective evaluation of a screen for complex discharge planning in hospitalized adults
    Diane E Holland
    Department of Nursing, Mayo Clinic, Rochester, Minnesota 55902, USA
    J Am Geriatr Soc 51:678-82. 2003
    ..To test the predictive ability of the Probability of Repeated Admission (PRA) screen for nonroutine discharge planning (requiring new referrals for formal services)...
  95. ncbi request reprint Sensitivity and specificity of the semiquantitative latex agglutination D-dimer assay for the diagnosis of acute pulmonary embolism as defined by computed tomographic angiography
    David A Froehling
    Division of Area General Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Mayo Clin Proc 79:164-8. 2004
    ....
  96. ncbi request reprint Correlates of lymphoproliferative responses to measles, mumps, and rubella (MMR) virus vaccines following MMR-II vaccination in healthy children
    Neelam Dhiman
    Mayo Vaccine Research Group, Mayo Clinic and Foundation, 611C Guggenheim Building, 200 First Street SW, Rochester, MN 55905, USA
    Clin Immunol 115:154-61. 2005
    ..This study demonstrates recall CMI post-MMR-II vaccination with significant intraclass correlation among the CMI responses to the three vaccine components...
  97. ncbi request reprint Prenatal and perinatal correlates of adult mammographic breast density
    James R Cerhan
    Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, Minnesota 55905, USA
    Cancer Epidemiol Biomarkers Prev 14:1502-8. 2005
    ..We examined the hypothesis that those factors associated with higher levels of estrogen during pregnancy or shortly after birth are associated with higher mammographic breast density in adulthood...
  98. ncbi request reprint Mammographic breast density as a general marker of breast cancer risk
    Celine M Vachon
    Mayo Clinic College of Medicine, Charlton 6 239, 200 First Street Southwest, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 16:43-9. 2007
    ..Overall mammographic density seems to represent a general marker of breast cancer risk that is not specific to breast side or location of the eventual cancer...
  99. pmc Effect of rater training on reliability and accuracy of mini-CEX scores: a randomized, controlled trial
    David A Cook
    Office of Education Research, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Gen Intern Med 24:74-9. 2009
    ..Mini-CEX scores assess resident competence. Rater training might improve mini-CEX score interrater reliability, but evidence is lacking...
  100. pmc A comprehensive examination of CYP19 variation and risk of breast cancer using two haplotype-tagging approaches
    Janet E Olson
    Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic College of Medicine, Rochester, MN 55901, USA
    Breast Cancer Res Treat 102:237-47. 2007
    ..We recently published resequencing data on 88 polymorphisms identified in that gene. The hypothesis tested in this study was that polymorphisms, or haplotypes, in CYP19 are related to risk of breast cancer...
  101. ncbi request reprint Psychiatric manifestations of Creutzfeldt-Jakob disease: a 25-year analysis
    Christopher A Wall
    Department of Psychiatry and Psychology, Mayo Clinic, Mayo Building W11A, 200 First Street SW, Rochester, MN 55905, USA
    J Neuropsychiatry Clin Neurosci 17:489-95. 2005
    ..Psychiatric manifestations are an early and prominent feature of sporadic CJD, often occurring prior to formal diagnosis...