W G Owen

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. ncbi request reprint PAR-3 is a low-affinity substrate, high affinity effector of thrombin
    Whyte G Owen
    Department of Biochemistry and Molecular Biology, Mayo Foundation for Medical Education and Research, Rochester, MN 55905 0002, USA
    Biochem Biophys Res Commun 305:166-8. 2003
  2. ncbi request reprint Big piece, little piece or: yes, factor VIII is a protein
    W G Owen
    Mayo Clinic College of Medicine, Department of Biochemistry and Molecular Biology, Rochester, MN 55905, USA
    J Thromb Haemost 3:1905-9. 2005
  3. ncbi request reprint In vivo effects of lipopolysaccharide and TLR4 on platelet production and activity: implications for thrombotic risk
    Muthuvel Jayachandran
    Department of Surgery, Mayo Clinic Rochester, 200 First St SW, Rochester, MN 55905, USA
    J Appl Physiol 102:429-33. 2007
  4. ncbi request reprint Differential effects of 17beta-estradiol, conjugated equine estrogen, and raloxifene on mRNA expression, aggregation, and secretion in platelets
    Muthuvel Jayachandran
    Department of Physiology and Bioengineering, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Am J Physiol Heart Circ Physiol 288:H2355-62. 2005
  5. ncbi request reprint Estrogenic regulation of tissue factor and tissue factor pathway inhibitor in platelets
    Muthuvel Jayachandran
    Dept of Surgery, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Am J Physiol Heart Circ Physiol 289:H1908-16. 2005
  6. pmc Aggregation and microparticle production through toll-like receptor 4 activation in platelets from recently menopausal women
    Kazunori Hashimoto
    Department of Surgery, College of Medicine, MayoClinic, Rochester, MN 55905, USA
    J Cardiovasc Pharmacol 54:57-62. 2009
  7. ncbi request reprint Atrial fibrillation and thrombosis: immunohistochemical differences between in situ and embolized thrombi
    W E Wysokinski
    Division of Cardiovascular Medicine, Mayo Clinic and Foundation for Education and Research, Rochester, MN 55905, USA
    J Thromb Haemost 2:1637-44. 2004
  8. ncbi request reprint Sex-specific changes in platelet aggregation and secretion with sexual maturity in pigs
    Muthuvel Jayachandran
    Dept of Surgery, Mayo Clinic Rochester, 200 First St SW, Rochester, MN 55905, USA
    J Appl Physiol 97:1445-52. 2004
  9. ncbi request reprint Platelet characteristics change with aging: role of estrogen receptor beta
    Muthuvel Jayachandran
    Department of Surgery, Physiology and Biophysics, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905
    J Gerontol A Biol Sci Med Sci 60:815-9. 2005
  10. ncbi request reprint The impact of peripheral arterial disease on circulating platelets
    Robert D McBane
    Section of Hematology Research, Mayo Clinic and Foundation for Education and Research, Rochester, MN 55905, USA
    Thromb Res 113:137-45. 2004

Collaborators

Detail Information

Publications34

  1. ncbi request reprint PAR-3 is a low-affinity substrate, high affinity effector of thrombin
    Whyte G Owen
    Department of Biochemistry and Molecular Biology, Mayo Foundation for Medical Education and Research, Rochester, MN 55905 0002, USA
    Biochem Biophys Res Commun 305:166-8. 2003
    ..The allosteric effect of PAR-3 is characteristic of that of Na(+)...
  2. ncbi request reprint Big piece, little piece or: yes, factor VIII is a protein
    W G Owen
    Mayo Clinic College of Medicine, Department of Biochemistry and Molecular Biology, Rochester, MN 55905, USA
    J Thromb Haemost 3:1905-9. 2005
  3. ncbi request reprint In vivo effects of lipopolysaccharide and TLR4 on platelet production and activity: implications for thrombotic risk
    Muthuvel Jayachandran
    Department of Surgery, Mayo Clinic Rochester, 200 First St SW, Rochester, MN 55905, USA
    J Appl Physiol 102:429-33. 2007
    ..The persistence of the effect 1 wk after the injection suggests that the changes reflect an action of LPS on megakaryocytes and their platelet progeny rather than on circulating platelets, which would have been cleared...
  4. ncbi request reprint Differential effects of 17beta-estradiol, conjugated equine estrogen, and raloxifene on mRNA expression, aggregation, and secretion in platelets
    Muthuvel Jayachandran
    Department of Physiology and Bioengineering, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Am J Physiol Heart Circ Physiol 288:H2355-62. 2005
    ..These differences reflect transcriptional and posttranscriptional regulation of protein synthesis in bone marrow megakaryocytes and circulating platelets...
  5. ncbi request reprint Estrogenic regulation of tissue factor and tissue factor pathway inhibitor in platelets
    Muthuvel Jayachandran
    Dept of Surgery, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Am J Physiol Heart Circ Physiol 289:H1908-16. 2005
    ..These studies provide the rationale for evaluation of interactions among platelets and TF and TFPI expression on thrombin generation during estrogen treatment in humans...
  6. pmc Aggregation and microparticle production through toll-like receptor 4 activation in platelets from recently menopausal women
    Kazunori Hashimoto
    Department of Surgery, College of Medicine, MayoClinic, Rochester, MN 55905, USA
    J Cardiovasc Pharmacol 54:57-62. 2009
    ....
  7. ncbi request reprint Atrial fibrillation and thrombosis: immunohistochemical differences between in situ and embolized thrombi
    W E Wysokinski
    Division of Cardiovascular Medicine, Mayo Clinic and Foundation for Education and Research, Rochester, MN 55905, USA
    J Thromb Haemost 2:1637-44. 2004
    ..Quantitative immunohistochemistry was undertaken to define the composition of atrial thrombi and to explore morphological differences between atrial appendage thrombi and those that embolize...
  8. ncbi request reprint Sex-specific changes in platelet aggregation and secretion with sexual maturity in pigs
    Muthuvel Jayachandran
    Dept of Surgery, Mayo Clinic Rochester, 200 First St SW, Rochester, MN 55905, USA
    J Appl Physiol 97:1445-52. 2004
    ..These observations provide evidence on which clinical studies could be designed to examine platelet characteristics in human children and young adults...
  9. ncbi request reprint Platelet characteristics change with aging: role of estrogen receptor beta
    Muthuvel Jayachandran
    Department of Surgery, Physiology and Biophysics, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905
    J Gerontol A Biol Sci Med Sci 60:815-9. 2005
    ..Therefore, deletion of betaER is associated with specific platelet functions, which are expressed only with age-associated reproductive senescence...
  10. ncbi request reprint The impact of peripheral arterial disease on circulating platelets
    Robert D McBane
    Section of Hematology Research, Mayo Clinic and Foundation for Education and Research, Rochester, MN 55905, USA
    Thromb Res 113:137-45. 2004
    ..To measure the effect of a defined arterial injury on platelet function, platelet samples were compared before and 30 min after elective angioplasty...
  11. ncbi request reprint Estrogen therapy and thrombotic risk
    Virginia M Miller
    Department of Surgery, Mayo Clinic College of Medicine, Rochester, MN 55905, United States
    Pharmacol Ther 111:792-807. 2006
    ....
  12. ncbi request reprint A prospective, randomized platelet-function study of heparinized oxygenators and cardiotomy suction
    Gregory A Nuttall
    Department of Surgery, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Cardiothorac Vasc Anesth 20:554-61. 2006
    ..The purpose of this study was to determine if substitution of a heparin-coated oxygenator and salvaged autologous blood for cardiotomy suction would improve platelet function...
  13. ncbi request reprint Effects of ovariectomy on aggregation, secretion, and metalloproteinases in porcine platelets
    Muthuvel Jayachandran
    Department of Surgery, Mayo Clinic Rochester, 200 First Street SW, Rochester, MN 55905, USA
    Am J Physiol Heart Circ Physiol 284:H1679-85. 2003
    ..Increased platelet aggregation and activity of MMP-2 would alter platelet-platelet and platelet-vessel wall interactions, contributing to an exaggerated response to injury with loss of ovarian hormones...
  14. ncbi request reprint Ovariectomy increases mitogens and platelet-induced proliferation of arterial smooth muscle
    M P Bracamonte
    Department of Physiology and Biophysics, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Am J Physiol Heart Circ Physiol 283:H853-60. 2002
    ..Higher levels of PDGF(BB) in platelets in synergy with other platelet-derived products could contribute to increased proliferative arterial response to injury after ovariectomy...
  15. ncbi request reprint Ageing, oestrogen, platelets and thrombotic risk
    Virginia M Miller
    Department of Surgery, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Clin Exp Pharmacol Physiol 34:814-21. 2007
    ..e. adhesion, aggregation, secretion and thrombin production) in individuals with documented hormonal status are needed to better understand how hormonal changes associated with ageing impact thrombotic risk...
  16. doi request reprint Estrogen, inflammation, and platelet phenotype
    Virginia M Miller
    Department of Surgery, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Gend Med 5:S91-S102. 2008
    ..Although exogenous estrogenic therapies increase the risk of thrombosis, the effects of estrogen on formed elements of blood are uncertain...
  17. pmc Characterization of blood borne microparticles as markers of premature coronary calcification in newly menopausal women
    Muthuvel Jayachandran
    Department of Surgery and Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 1st St SW, Rochester, MN 55905, USA
    Am J Physiol Heart Circ Physiol 295:H931-H938. 2008
    ..Therefore, the characterization of platelet and endothelial microparticles may identify early menopausal women with premature CAC who would not otherwise be identified by the usual risk factor analysis...
  18. pmc Loss of estrogen receptor beta decreases mitochondrial energetic potential and increases thrombogenicity of platelets in aged female mice
    Muthuvel Jayachandran
    Department of Surgery, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN, 55905, USA
    Age (Dordr) 32:109-21. 2010
    ....
  19. ncbi request reprint Thrombomodulin gene polymorphisms or haplotypes as potential risk factors for venous thromboembolism: a population-based case-control study
    John A Heit
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MI, USA
    J Thromb Haemost 3:710-7. 2005
    ..Null genetic marker allele frequencies did not differ significantly among cases and controls. We conclude that polymorphisms or haplotypes within the TM gene are not common risk factors for incident VTE...
  20. pmc Procoagulant activity, but not number, of microparticles increases with age and in individuals after a single venous thromboembolism
    B A L Owen
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA
    Thromb Res 127:39-46. 2011
    ....
  21. ncbi request reprint Factors that influence platelet recovery after transfusion: resolving donor quality from ABO compatibility
    Teresa M Jiménez
    Section of Hematology Research, Division of Transfusion Medicine and Department of Biochemistry and Molecular Biology, Mayo Clinics and Foundation, Rochester, Minnesota 55905, USA
    Transfusion 43:328-34. 2003
    ..A system was established to examine the extent to which the apheresis donor determines platelet recovery after transfusion, to measure the impact of ABO identity, and to predict outcome by evaluating the donor...
  22. ncbi request reprint Thrombin induced inhibition of neurite outgrowth from dorsal root ganglion neurons
    J S Gill
    Molecular Neuroscience Program, Mayo Clinic and Mayo Foundation, 1501 Guggenheim Building, 200 First Street SW, Rochester, MN 55905, USA gi
    Brain Res 797:321-7. 1998
    ..These findings are the first to describe the localization of the thrombin receptor to dorsal root ganglion neurons. We propose that receptor activation is associated with thrombin induced inhibition of neurite outgrowth...
  23. ncbi request reprint A highly-sensitive plasma von Willebrand factor ristocetin cofactor (VWF:RCo) activity assay by flow cytometry
    D Chen
    Special Coagulation Laboratory, Division of Hematopathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Thromb Haemost 6:323-30. 2008
    ..However, current manual or automated VWF:RCo assay methods have relatively poor operating characteristics. Our goal was to develop and validate a simple, accurate, specific and sensitive platelet-based VWF:RCo assay...
  24. ncbi request reprint Platelet characteristics associated with coronary artery disease
    R D McBane
    Division of Cardiovascular Medicine, Section of Hematology Research, Mayo Clinic and Foundation for Education and Research, 200 S W First Street, Rochester, MN 55905, USA
    J Thromb Haemost 1:1296-303. 2003
    ..To measure the effect of angioplasty on platelet function, samples obtained before, 30 min after and 24 h after angioplasty were compared...
  25. ncbi request reprint Inhibition and reversal of platelet-rich arterial thrombus in vivo: direct vs. indirect factor Xa inhibition
    K Karnicki
    Division of Cardiology, May Clinic, Rochester, MN 55905, USA
    J Thromb Haemost 2:2162-9. 2004
    ..The efficacy of a direct factor (F)Xa inhibitor, ZK-807834, was compared with indirect inhibition by enoxaparin for inhibition and deaggregation of acute platelet-rich thrombi in a well-characterized porcine carotid injury model...
  26. ncbi request reprint Factors contributing to individual propensity for arterial thrombosis
    Krzysztof Karnicki
    Section of Hematology Research, Mayo Clinic and Foundation for Education and Research, Rochester, Minn 55905, USA
    Arterioscler Thromb Vasc Biol 22:1495-9. 2002
    ....
  27. ncbi request reprint Influence of anatomical location on arterial thrombosis
    Krzysztof Karnicki
    Division of Cardiovascular Medicine, Mayo Clinic and Foundation for Education and Research, Rochester, MN 55905, USA
    Arterioscler Thromb Vasc Biol 22:342-7. 2002
    ..Regional differences in arterial hemodynamics may account for substantial differences in thrombosis arising from deep arterial injury...
  28. ncbi request reprint Fechtner syndrome: physiologic analysis of macrothrombocytopenia
    R D McBane
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Blood Coagul Fibrinolysis 11:243-7. 2000
    ..This case illustrates that 'giant' platelets are not universally present in Fechtner syndrome cases, although the platelets are enlarged. Finally, renal pathology other than Alport's nephropathy may be associated with this syndrome...
  29. pmc Iron-dependent self-assembly of recombinant yeast frataxin: implications for Friedreich ataxia
    J Adamec
    Departments of Pediatric and Adolescent Medicine and Biochemistry and Molecular Biology, Mayo Clinic and Foundation, Rochester, MN, USA
    Am J Hum Genet 67:549-62. 2000
    ..We propose that iron-dependent self-assembly of recombinant mYfh1p reflects a physiological role for frataxin in mitochondrial iron sequestration and bioavailability...
  30. pmc Kinetic analysis of interaction of BRCA1 tandem breast cancer c-terminal domains with phosphorylated peptides reveals two binding conformations
    Yves Nominé
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, Minnesota 55905, USA
    Biochemistry 47:9866-79. 2008
    ..The dynamic nature of BRCA1-BRCT may facilitate the binding of BRCA1 to different phosphorylated protein targets...
  31. pmc Circulating microparticles and endogenous estrogen in newly menopausal women
    M Jayachandran
    Department of Surgery, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Climacteric 12:177-84. 2009
    ..A marker of these modulatory activities is formation of cell-specific microparticles. This study examined the relationship between blood-borne microparticles and endogenous estrogen at menopause...
  32. pmc The anticancer agent chaetocin is a competitive substrate and inhibitor of thioredoxin reductase
    Jennifer D Tibodeau
    Division of Medical Oncology, Department of Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Antioxid Redox Signal 11:1097-106. 2009
    ....
  33. ncbi request reprint Physical evidence that yeast frataxin is an iron storage protein
    Oleksandr Gakh
    Departments of Pediatric and Adolescent Medicine, Biochemistry and Molecular Biology, and Pharmacology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Biochemistry 41:6798-804. 2002
    ..These findings support the hypothesis that frataxin is an iron storage protein, which could explain the mitochondrial iron accumulation and oxidative damage associated with frataxin defects in yeast, mouse, and humans...
  34. ncbi request reprint Binding stoichiometry of an RNA aptamer and its transcription factor target
    Laura A Cassiday
    Department of Biochemistry and Molecular Biology, Mayo Foundation, Rochester, Minnesota 55905, USA
    Anal Biochem 306:290-7. 2002
    ..This work also demonstrates the successful application of mass spectrometry to characterize noncovalent RNA/protein interactions...