TIMOTHY MARK OLSON

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Histoplasmosis infection in patients with rheumatoid arthritis, 1998-2009
    Timothy C Olson
    Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    BMC Infect Dis 11:145. 2011
  2. pmc Human K(ATP) channelopathies: diseases of metabolic homeostasis
    Timothy M Olson
    Marriott Heart Disease Research Program, Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Pflugers Arch 460:295-306. 2010
  3. pmc KATP channel mutation confers risk for vein of Marshall adrenergic atrial fibrillation
    Timothy M Olson
    Marriott Heart Disease Research Program, Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Nat Clin Pract Cardiovasc Med 4:110-6. 2007
  4. ncbi request reprint What makes the heart fail? New insights from defective genes
    Timothy M Olson
    Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Acta Paediatr Suppl 95:17-21. 2006
  5. pmc Sodium channel mutations and susceptibility to heart failure and atrial fibrillation
    Timothy M Olson
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    JAMA 293:447-54. 2005
  6. ncbi request reprint Inherited and de novo mutations in the cardiac actin gene cause hypertrophic cardiomyopathy
    T M Olson
    Department of Pediatrics, Division of Pediatric Cardiology, Salt Lake City, UT 84113, USA
    J Mol Cell Cardiol 32:1687-94. 2000
  7. ncbi request reprint Mutations that alter the surface charge of alpha-tropomyosin are associated with dilated cardiomyopathy
    T M Olson
    Department of Pediatrics, Division of Cardiology and Biochemistry, University of Utah, Salt Lake City, UT 84113, USA
    J Mol Cell Cardiol 33:723-32. 2001
  8. ncbi request reprint Myosin light chain mutation causes autosomal recessive cardiomyopathy with mid-cavitary hypertrophy and restrictive physiology
    Timothy M Olson
    Department of Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Circulation 105:2337-40. 2002
  9. ncbi request reprint Metavinculin mutations alter actin interaction in dilated cardiomyopathy
    Timothy M Olson
    Department of Pediatrics and the Division of Cardiology, University of Utah, Salt Lake City, Utah, USA
    Circulation 105:431-7. 2002
  10. pmc Mutations in ribonucleic acid binding protein gene cause familial dilated cardiomyopathy
    Katharine M Brauch
    Cardiovascular Genetics Laboratory, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA
    J Am Coll Cardiol 54:930-41. 2009

Detail Information

Publications25

  1. pmc Histoplasmosis infection in patients with rheumatoid arthritis, 1998-2009
    Timothy C Olson
    Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    BMC Infect Dis 11:145. 2011
    ..Patients with rheumatic diseases including rheumatoid arthritis (RA) are at increased risk for infections related to both the disease and its treatments. These include uncommonly reported infections due to histoplasmosis...
  2. pmc Human K(ATP) channelopathies: diseases of metabolic homeostasis
    Timothy M Olson
    Marriott Heart Disease Research Program, Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Pflugers Arch 460:295-306. 2010
    ..Thus, advances in molecular medicine in the emerging field of human KATP channelopathies offer new opportunities for targeted individualized screening, early diagnosis, and tailored therapy...
  3. pmc KATP channel mutation confers risk for vein of Marshall adrenergic atrial fibrillation
    Timothy M Olson
    Marriott Heart Disease Research Program, Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Nat Clin Pract Cardiovasc Med 4:110-6. 2007
    ..In the absence of traditional risk factors for disease, a genetic defect in electrical homeostasis underlying stress-induced AF was explored...
  4. ncbi request reprint What makes the heart fail? New insights from defective genes
    Timothy M Olson
    Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Acta Paediatr Suppl 95:17-21. 2006
    ..CONCLUSION: Collectively, family-based studies of DCM provide the rationale for clinical screening in first-degree relatives, regardless of family history or age of the index case...
  5. pmc Sodium channel mutations and susceptibility to heart failure and atrial fibrillation
    Timothy M Olson
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    JAMA 293:447-54. 2005
    ..Recently, genetic defects in calcium and potassium regulation have been discovered in patients with DCM, implicating an alternative disease mechanism. The full spectrum of genetic defects in DCM, however, has not been established...
  6. ncbi request reprint Inherited and de novo mutations in the cardiac actin gene cause hypertrophic cardiomyopathy
    T M Olson
    Department of Pediatrics, Division of Pediatric Cardiology, Salt Lake City, UT 84113, USA
    J Mol Cell Cardiol 32:1687-94. 2000
    ..These findings support the hypothesis that a single amino acid substitution in actin causes either congestive heart failure or maladaptive cardiac hypertrophy, depending on its effect on actin structure and function...
  7. ncbi request reprint Mutations that alter the surface charge of alpha-tropomyosin are associated with dilated cardiomyopathy
    T M Olson
    Department of Pediatrics, Division of Cardiology and Biochemistry, University of Utah, Salt Lake City, UT 84113, USA
    J Mol Cell Cardiol 33:723-32. 2001
    ..Therefore, substitution of different amino acid residues in the same thin filament proteins is associated with the distinct phenotypes of cardiac hypertrophy or congestive heart failure...
  8. ncbi request reprint Myosin light chain mutation causes autosomal recessive cardiomyopathy with mid-cavitary hypertrophy and restrictive physiology
    Timothy M Olson
    Department of Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Circulation 105:2337-40. 2002
    ..Autosomal dominant hypertrophic cardiomyopathy (HCM) is caused by inherited defects of sarcomeric proteins. We tested the hypothesis that homozygosity for a sarcomeric protein defect can cause recessive HCM...
  9. ncbi request reprint Metavinculin mutations alter actin interaction in dilated cardiomyopathy
    Timothy M Olson
    Department of Pediatrics and the Division of Cardiology, University of Utah, Salt Lake City, Utah, USA
    Circulation 105:431-7. 2002
    ..We tested the hypothesis that heritable dysfunction of metavinculin may contribute to the pathogenesis of dilated cardiomyopathy (DCM)...
  10. pmc Mutations in ribonucleic acid binding protein gene cause familial dilated cardiomyopathy
    Katharine M Brauch
    Cardiovascular Genetics Laboratory, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA
    J Am Coll Cardiol 54:930-41. 2009
    ..We sought to identify a novel gene for dilated cardiomyopathy (DCM)...
  11. pmc The effect of the brain-type natriuretic peptide single-nucleotide polymorphism rs198389 on test characteristics of common assays
    Lisa C Costello-Boerrigter
    Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 86:210-8. 2011
    ....
  12. pmc A human atrial natriuretic peptide gene mutation reveals a novel peptide with enhanced blood pressure-lowering, renal-enhancing, and aldosterone-suppressing actions
    Paul M McKie
    Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 54:1024-32. 2009
    ..We sought to determine the physiologic actions and potential therapeutic applications of mutant atrial natriuretic peptide (mANP)...
  13. pmc Atrial natriuretic peptide frameshift mutation in familial atrial fibrillation
    Denice M Hodgson-Zingman
    Department of Internal Medicine, University of Iowa, Carver College of Medicine, Iowa City, USA
    N Engl J Med 359:158-65. 2008
    ..This report implicates perturbation of the atrial natriuretic peptide-cyclic guanosine monophosphate (cGMP) pathway in cardiac electrical instability...
  14. ncbi request reprint Familial atrial fibrillation is a genetically heterogeneous disorder
    Dawood Darbar
    Department of Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 41:2185-92. 2003
    ..The aims of this study were to identify and characterize familial cases of atrial fibrillation (AF) in our clinical practice and to determine whether AF is genetically heterogeneous...
  15. pmc ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gating
    Martin Bienengraeber
    Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic College of Medicine, Mayo Foundation, Rochester, Minnesota 55905, USA
    Nat Genet 36:382-7. 2004
    ..Defective catalysis-mediated pore regulation is thus a mechanism for channel dysfunction and susceptibility to dilated cardiomyopathy...
  16. ncbi request reprint Frequency of development of idiopathic dilated cardiomyopathy among relatives of patients with idiopathic dilated cardiomyopathy
    Virginia V Michels
    Department of Medical Genetics, Mayo Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Am J Cardiol 91:1389-92. 2003
  17. pmc Cardiac KATP channels in health and disease
    Garvan C Kane
    Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Mol Cell Cardiol 38:937-43. 2005
    ....
  18. ncbi request reprint Identification of a metavinculin missense mutation, R975W, associated with both hypertrophic and dilated cardiomyopathy
    Vlad C Vasile
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Mol Genet Metab 87:169-74. 2006
    ..However, this study demonstrates that the same fundamental mutation in humans can yield either cardiomyopathic phenotype, underscoring a critical role for modifier genes and/or environmental stressors in cardiac remodeling...
  19. ncbi request reprint Kv1.5 channelopathy due to KCNA5 loss-of-function mutation causes human atrial fibrillation
    Timothy M Olson
    Department of Medicine, Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Hum Mol Genet 15:2185-91. 2006
    ..This first report of Kv1.5 loss-of-function channelopathy establishes KCNA5 mutation as a novel risk factor for repolarization deficiency and atrial fibrillation...
  20. pmc Comprehensive mutation scanning of LMNA in 268 patients with lone atrial fibrillation
    Katharine M Brauch
    Cardiovascular Genetics Laboratory, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Am J Cardiol 103:1426-8. 2009
    ..Comprehensive mutation scanning identified only 1 potentially pathogenic mutation. In conclusion, LMNA mutations rarely cause lone AF and routine genetic testing of LMNA in these patients does not appear warranted...
  21. pmc X-linked nonsyndromic sinus node dysfunction and atrial fibrillation caused by emerin mutation
    Margaret L Karst
    Department of Medicine, Division of Cardiovascular Diseases, and Pediatric and Adolescent Medicine, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Cardiovasc Electrophysiol 19:510-5. 2008
    ..This study sought to identify the genetic basis for male-restricted, nonsyndromic sinus node dysfunction and AF in a multigenerational family...
  22. pmc K(ATP) channel polymorphism is associated with left ventricular size in hypertensive individuals: a large-scale community-based study
    Santiago Reyes
    Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, MN, USA
    Hum Genet 123:665-7. 2008
    ..These findings implicate Kir6.2 K23 as a risk factor for adverse subclinical myocardial remodeling, and underscore the significance of cardiac K(ATP) channels within the population...
  23. ncbi request reprint Gene mutations in apical hypertrophic cardiomyopathy
    Michael Arad
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Circulation 112:2805-11. 2005
    ..The genetic relationship between HCM with typical hypertrophic morphology versus isolated apical hypertrophy is incompletely understood...
  24. pmc Lone atrial fibrillation: influence of familial disease on gender predilection
    Lin Y Chen
    Department of Medicine, Cardiovascular Division, National University of Singapore, Singapore
    J Cardiovasc Electrophysiol 19:802-6. 2008
    ..We sought to determine gender distribution in sporadic and familial LAF, gender-based differences, and phenotypic differences between sporadic and familial LAF...
  25. ncbi request reprint Inherited arrhythmias: a National Heart, Lung, and Blood Institute and Office of Rare Diseases workshop consensus report about the diagnosis, phenotyping, molecular mechanisms, and therapeutic approaches for primary cardiomyopathies of gene mutations affe
    Stephan E Lehnart
    Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, College of Physicians and Surgeons of Columbia University, P and S 9 401 box 22, 630 W 168 St, New York, NY 10032, USA
    Circulation 116:2325-45. 2007
    ....

Research Grants12

  1. Identification of Disease Genes for Atrial Fibrillation
    Timothy Olson; Fiscal Year: 2007
    ..The long-term objectives of this work are to gain new insights into molecular mechanisms of arrhythmogenesis and to improve prediction, prevention, and treatment of AF. ..
  2. Identification of Disease Genes for Atrial Fibrillation
    Timothy Olson; Fiscal Year: 2009
    ..The long-term objectives of this work are to gain new insights into molecular mechanisms of arrhythmogenesis and to improve prediction, prevention, and treatment of AF. ..
  3. Mapping Novel Disease Genes for Dilated Cardiomyopathy
    Timothy Olson; Fiscal Year: 2007
    ..Discovering the genetic basis of DCM will lead to better ways to diagnose and prevent the progressive weakening of heart muscle that afflicts patients with this disorder. ..
  4. Mapping Novel Disease Genes for Dilated Cardiomyopathy
    Timothy Olson; Fiscal Year: 2004
    ..The long-term objectives of this work are to gain new insights into molecular mechanisms for heart failure and to improve prediction, prevention, and treatment of DCM. ..
  5. Mapping Novel Disease Genes for Dilated Cardiomyopathy
    TIMOTHY MARK OLSON; Fiscal Year: 2010
    ..Discovering the genetic basis of DCM will lead to better ways to diagnose and prevent the progressive weakening of heart muscle that afflicts patients with this disorder. ..