Ann L Oberg

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. ncbi request reprint Joint estimation of calibration and expression for high-density oligonucleotide arrays
    Ann L Oberg
    Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic College of Medicine 200 First Street SW, Rochester, MN 55905, USA
    Bioinformatics 22:2381-7. 2006
  2. pmc Technical and biological variance structure in mRNA-Seq data: life in the real world
    Ann L Oberg
    Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA
    BMC Genomics 13:304. 2012
  3. pmc Statistical methods for quantitative mass spectrometry proteomic experiments with labeling
    Ann L Oberg
    Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    BMC Bioinformatics 13:S7. 2012
  4. pmc RNA-seq: technical variability and sampling
    Lauren M McIntyre
    Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, USA
    BMC Genomics 12:293. 2011
  5. pmc Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states
    Aaron L Sarver
    Biostatistics and Informatics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA
    BMC Cancer 9:401. 2009
  6. pmc Statistical analysis of relative labeled mass spectrometry data from complex samples using ANOVA
    Ann L Oberg
    Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    J Proteome Res 7:225-33. 2008
  7. pmc Fatty acids found in dairy, protein and unsaturated fatty acids are associated with risk of pancreatic cancer in a case-control study
    Rick J Jansen
    Division of Epidemiology Department of Health Sciences Research, Mayo Clinic, Rochester, MN
    Int J Cancer 134:1935-46. 2014
  8. pmc Nutrients from fruit and vegetable consumption reduce the risk of pancreatic cancer
    Rick J Jansen
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Gastrointest Cancer 44:152-61. 2013
  9. pmc Relationship of volumetric bone density and structural parameters at different skeletal sites to sex steroid levels in women
    Sundeep Khosla
    Mayo Clinic, Endocrine Research Unit, 200 First Street SW, 5 194 Joseph, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 90:5096-103. 2005
  10. ncbi request reprint Does reduced skeletal loading account for age-related bone loss?
    L Joseph Melton
    Division of Epidemiology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Bone Miner Res 21:1847-55. 2006

Detail Information

Publications76

  1. ncbi request reprint Joint estimation of calibration and expression for high-density oligonucleotide arrays
    Ann L Oberg
    Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic College of Medicine 200 First Street SW, Rochester, MN 55905, USA
    Bioinformatics 22:2381-7. 2006
    ..The need for normalization in microarray experiments has been well documented in the literature. Currently, many analysis methods treat normalization and analysis as a series of steps, with summarized data carried forward to the next step...
  2. pmc Technical and biological variance structure in mRNA-Seq data: life in the real world
    Ann L Oberg
    Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA
    BMC Genomics 13:304. 2012
    ..The Negative Binomial distribution which allows for over-dispersion, i.e., for the variance to be greater than the mean, is commonly used to model count data as well...
  3. pmc Statistical methods for quantitative mass spectrometry proteomic experiments with labeling
    Ann L Oberg
    Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    BMC Bioinformatics 13:S7. 2012
    ..Concepts are illustrated through the use of three case studies utilizing the iTRAQ 4-plex labeling protocol...
  4. pmc RNA-seq: technical variability and sampling
    Lauren M McIntyre
    Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, USA
    BMC Genomics 12:293. 2011
    ..However, strategies for dealing with technical variation will differ depending on the magnitude. The size of technical variance, and the role of sampling are examined in this manuscript...
  5. pmc Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states
    Aaron L Sarver
    Biostatistics and Informatics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA
    BMC Cancer 9:401. 2009
    ..Differential miRNA expression in cancer versus normal tissue is a common event and may be pivotal for tumor onset and progression...
  6. pmc Statistical analysis of relative labeled mass spectrometry data from complex samples using ANOVA
    Ann L Oberg
    Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    J Proteome Res 7:225-33. 2008
    ..The modeling approach, implementation, and useful visualization tools are demonstrated via a case study of complex biological samples assessed using the iTRAQ relative labeling protocol...
  7. pmc Fatty acids found in dairy, protein and unsaturated fatty acids are associated with risk of pancreatic cancer in a case-control study
    Rick J Jansen
    Division of Epidemiology Department of Health Sciences Research, Mayo Clinic, Rochester, MN
    Int J Cancer 134:1935-46. 2014
    ..23-2.74]). Our study suggests that eating a diet high in total protein and certain unsaturated FAs is associated with decreased risk of developing pancreatic cancer in a dose-dependent manner, whereas fats found in dairy increase risk. ..
  8. pmc Nutrients from fruit and vegetable consumption reduce the risk of pancreatic cancer
    Rick J Jansen
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Gastrointest Cancer 44:152-61. 2013
    ..Our objective was to evaluate the risk of pancreatic cancer associated with nutrients found in fruits and vegetables and nutrient supplementation using a clinic-based case-control design...
  9. pmc Relationship of volumetric bone density and structural parameters at different skeletal sites to sex steroid levels in women
    Sundeep Khosla
    Mayo Clinic, Endocrine Research Unit, 200 First Street SW, 5 194 Joseph, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 90:5096-103. 2005
    ..There are no data testing this in women...
  10. ncbi request reprint Does reduced skeletal loading account for age-related bone loss?
    L Joseph Melton
    Division of Epidemiology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Bone Miner Res 21:1847-55. 2006
    ..However, in a population-based study of 375 women and 325 men (age, 21-97 years), we failed to find a close correspondence between these variables and changes in bone strength with aging...
  11. ncbi request reprint Population-based analysis of the relationship of whole bone strength indices and fall-related loads to age- and sex-specific patterns of hip and wrist fractures
    B Lawrence Riggs
    Endocrine Research Unit, Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Bone Miner Res 21:315-23. 2006
    ..These load/strength ratios more closely simulated patterns of wrist and hip fractures occurring in the same population than did measurement of vBMD...
  12. pmc Polymorphisms in metabolism/antioxidant genes may mediate the effect of dietary intake on pancreatic cancer risk
    Rick J Jansen
    From the Divisions of Epidemiology, and Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN Department of Epidemiology, National Institutes of Health, Bethesda, MD Department of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN and Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD
    Pancreas 42:1043-53. 2013
    ..Seventy-six tag single-nucleotide polymorphisms were genotyped in 13 candidate genes to test differential associations with pancreatic adenocarcinoma...
  13. pmc Genome-wide characterization of transcriptional patterns in high and low antibody responders to rubella vaccination
    Iana H Haralambieva
    Vaccine Research Group, Mayo Clinic, Rochester, Minnesota, USA
    PLoS ONE 8:e62149. 2013
    ..Such information may provide new scientific insights into vaccine-induced immunity useful in rational vaccine development and immune response monitoring...
  14. pmc Meat-related mutagens and pancreatic cancer: null results from a clinic-based case-control study
    Rick J Jansen
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 22:1336-9. 2013
    ..The study objective was to evaluate risk of pancreatic cancer associated with meat preparation methods and meat-related mutagen consumption using a clinic-based case-control design...
  15. pmc High-dimensional gene expression profiling studies in high and low responders to primary smallpox vaccination
    Iana H Haralambieva
    Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Infect Dis 206:1512-20. 2012
    ..The mechanisms underlying smallpox vaccine-induced variations in immune responses are not well understood, but are of considerable interest to a deeper understanding of poxvirus immunity and correlates of protection...
  16. pmc Effects of sex and age on bone microstructure at the ultradistal radius: a population-based noninvasive in vivo assessment
    Sundeep Khosla
    Endocrine Research Unit, Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Bone Miner Res 21:124-31. 2006
    ..Compared with women, men had thicker trabeculae in young adulthood and had less microstructural damage with aging. These findings may contribute to the virtual immunity of men to age-related increases in wrist fractures...
  17. ncbi request reprint Hormonal and biochemical determinants of trabecular microstructure at the ultradistal radius in women and men
    Sundeep Khosla
    Mayo Clinic, Endocrine Research Unit, 200 First Street SW, 5 194 Joseph, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 91:885-91. 2006
    ....
  18. pmc Gene networks and microRNAs implicated in aggressive prostate cancer
    Liang Wang
    Department of Laboratory Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Cancer Res 69:9490-7. 2009
    ....
  19. ncbi request reprint Faster cyclic loess: normalizing RNA arrays via linear models
    Karla V Ballman
    Division of Biostatistics, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Bioinformatics 20:2778-86. 2004
    ..Our goal was to develop a normalization technique that yields results similar to cyclic loess normalization and with speed comparable to quantile normalization...
  20. ncbi request reprint Relationship of volumetric BMD and structural parameters at different skeletal sites to sex steroid levels in men
    Sundeep Khosla
    Endocrine Research Unit, Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Bone Miner Res 20:730-40. 2005
    ..Associations between these bone mass/structural parameters and sex steroid levels were progressively stronger with age. Our previously postulated "threshold" for skeletal estrogen deficiency was most evident at cortical sites...
  21. ncbi request reprint Long-term fracture risk among women with proven endometriosis
    L Joseph Melton
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Fertil Steril 86:1576-83. 2006
    ..To determine whether women with pelvic endometriosis are at increased fracture risk...
  22. doi request reprint Genomic and proteomic analysis of myocarditis and dilated cardiomyopathy
    Leslie T Cooper
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Heart Fail Clin 6:75-85. 2010
    ..This article reviews several examples of noncandidate genomic and proteomic screening, as well as the potential strengths and pitfalls of these strategies for the evaluation of myocarditis and nonischemic DCM...
  23. pmc miRNA expression in colon polyps provides evidence for a multihit model of colon cancer
    Ann L Oberg
    Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 6:e20465. 2011
    ..The comparison between pMMR and dMMR tumors identified four miRNAs (miR-31, miR-552, miR-592 and miR-224) with statistically significant expression differences (≥2-fold change)...
  24. pmc Vaccinomics, adversomics, and the immune response network theory: individualized vaccinology in the 21st century
    Gregory A Poland
    Mayo Clinic Vaccine Research Group, Rochester, MN 55905, USA
    Semin Immunol 25:89-103. 2013
    ..Herein, we discuss the above with a view toward the future of vaccinology. ..
  25. pmc 3' tag digital gene expression profiling of human brain and universal reference RNA using Illumina Genome Analyzer
    Yan W Asmann
    Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
    BMC Genomics 10:531. 2009
    ..In this preliminary effort, we evaluated the 3' DGE approach using two reference RNA samples from the MicroArray Quality Control Consortium (MAQC)...
  26. pmc Relative quantification: characterization of bias, variability and fold changes in mass spectrometry data from iTRAQ-labeled peptides
    Douglas W Mahoney
    Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, United States
    J Proteome Res 10:4325-33. 2011
    ..Fold changes were biased toward the null and variance of a fold change was a function of protein mass and abundance. The information presented herein will be valuable for experimental design and analysis of the resulting data...
  27. pmc A phase II study of gemcitabine in combination with tanespimycin in advanced epithelial ovarian and primary peritoneal carcinoma
    Andrea E Wahner Hendrickson
    Division of Medical Oncology, Mayo Clinic, Rochester, MN 55905, USA
    Gynecol Oncol 124:210-5. 2012
    ..To assess the effect of tanespimycin on tumor cells, levels of the chaperone proteins HSP90 and HSP70 were examined in peripheral blood mononuclear cells (PBMC) and paired tumor biopsy lysates...
  28. ncbi request reprint Fracture risk in monoclonal gammopathy of undetermined significance
    L Joseph Melton
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    J Bone Miner Res 19:25-30. 2004
    ..There was a 2.7-fold increase in the risk of axial fractures but no increase in limb fractures. The pathophysiologic basis for the increased axial fractures should be determined...
  29. pmc The ratios of CD8+ T cells to CD4+CD25+ FOXP3+ and FOXP3- T cells correlate with poor clinical outcome in human serous ovarian cancer
    Claudia C Preston
    Department of Immunology, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 8:e80063. 2013
    ..Thus, immunotherapy strategies that modify the ratio of CD4(+)CD25(+)FOXP3(+) Tregs or CD4(+)CD25(+)FOXP3(-) T cells to CD8(+) effector cells may be useful in improving outcomes in ovarian cancer. ..
  30. pmc Multi-platform analysis of microRNA expression measurements in RNA from fresh frozen and FFPE tissues
    Christopher P Kolbert
    Medical Genome Facility Gene Expression Core, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 8:e52517. 2013
    ....
  31. ncbi request reprint A phase 2 trial of flavopiridol (Alvocidib) and cisplatin in platin-resistant ovarian and primary peritoneal carcinoma: MC0261
    Keith C Bible
    Division of Medical Oncology, Department of Health Science Research, Mayo Clinic, Rochester, MN 55905, USA
    Gynecol Oncol 127:55-62. 2012
    ..Based upon promising preclinical and phase 1 trial results, combined flavopiridol and cisplatin therapy was evaluated in patients with ovarian and primary peritoneal cancers...
  32. ncbi request reprint A method for automatically interpreting mass spectra of 18O-labeled isotopic clusters
    Christopher J Mason
    Mayo Proteomics Research Center, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Mol Cell Proteomics 6:305-18. 2007
    ..We describe in detail the operation of the algorithm and demonstrate its use on datasets with known and unknown ratios...
  33. ncbi request reprint Linear mixed effects models
    Ann L Oberg
    Division of Biostatistics, Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, USA
    Methods Mol Biol 404:213-34. 2007
    ..As demonstrated in this chapter, linear mixed effects models provide a versatile and powerful framework in which to address research objectives efficiently and appropriately...
  34. pmc Optimizing high dimensional gene expression studies for immune response following smallpox vaccination using Taqman® low density immune arrays
    Ann L Oberg
    Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol Methods 366:69-78. 2011
    ..We sought to determine the time and vaccinia virus dose combination that would maximize the number of acute immune response changes in response to vaccinia stimulation in preparation for a large gene expression microarray experiment...
  35. ncbi request reprint Fracture risk after the diagnosis of Parkinson's disease: Influence of concomitant dementia
    L Joseph Melton
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Mov Disord 21:1361-7. 2006
    ..1). The increased fracture risk in patients with PD is not entirely explained by concomitant dementia, and additional study is needed to determine the relative contributions to fracture risk of falls versus bone loss in these patients...
  36. ncbi request reprint Incidence of primary hyperparathyroidism in Rochester, Minnesota, 1993-2001: an update on the changing epidemiology of the disease
    Robert A Wermers
    Division of Endocrinology, Department of Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    J Bone Miner Res 21:171-7. 2006
    ..The lower rates previously noted persisted, whereas parathyroidectomies at our institution remained high. These data suggest an etiologic factor may be responsible for the peak incidence in the 1970s...
  37. ncbi request reprint Long-term fracture risk following adult-onset asthma: a population-based study
    L Joseph Melton
    Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street S W, Rochester, MN 55905, USA
    Osteoporos Int 15:311-6. 2004
    ....
  38. pmc Dehydroepiandrosterone replacement therapy in hypoadrenal women: protein anabolism and skeletal muscle function
    Ketan K Dhatariya
    Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 83:1218-25. 2008
    ..To determine whether dehydroepiandrosterone (DHEA) replacement therapy in hypoadrenal women improves performance, muscle protein accretion, and mitochondrial functions...
  39. pmc Aspirin, nonsteroidal anti-inflammatory drugs, acetaminophen, and pancreatic cancer risk: a clinic-based case-control study
    Xiang Lin Tan
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Cancer Prev Res (Phila) 4:1835-41. 2011
    ..Our data suggest that aspirin use, but not non-aspirin NSAID use, is associated with lowered risk of developing pancreatic cancer...
  40. pmc Expression profiling of formalin-fixed paraffin-embedded primary breast tumors using cancer-specific and whole genome gene panels on the DASL® platform
    Monica M Reinholz
    Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First St SW, Rochester, Minnesota 55905, USA
    BMC Med Genomics 3:60. 2010
    ..5K) and 24,526-gene panel (24K) platforms at differentiating nine human epidermal growth factor receptor 2- positive (HER2+) and 11 HER2-negative (HER2-) paraffin-embedded breast tumors...
  41. pmc Systems biology approaches to new vaccine development
    Ann L Oberg
    Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, United States
    Curr Opin Immunol 23:436-43. 2011
    ..We also provide applied examples and point out new directions for the field in order to illustrate the power of systems biology...
  42. doi request reprint Statistical design of quantitative mass spectrometry-based proteomic experiments
    Ann L Oberg
    Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
    J Proteome Res 8:2144-56. 2009
    ..We illustrate the discussion using theoretical considerations, and using real-data examples of profiling of disease...
  43. ncbi request reprint Relationship of estrogen receptor genotypes to bone mineral density and to rates of bone loss in men
    Sundeep Khosla
    Endocrine Research Unit, Division of Endocrinology, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 89:1808-16. 2004
    ....
  44. ncbi request reprint "Diabetic mastopathy," or sclerosing lymphocytic lobulitis, is strongly associated with type 1 diabetes
    Yogish C Kudva
    Division of Endocrinology and Metabolism, Mayo Clinic, Rochester, Minnesota 55905 0001, USA
    Diabetes Care 25:121-6. 2002
    ..To demonstrate the strong association of diabetic mastopathy or sclerosing lymphocytic lobulitis with type 1 diabetes mellitus by studying appropriate control groups and to describe risk factors and natural history of the disorder...
  45. ncbi request reprint Papillary thyroid carcinoma managed at the Mayo Clinic during six decades (1940-1999): temporal trends in initial therapy and long-term outcome in 2444 consecutively treated patients
    Ian D Hay
    Department of Internal Medicine, Division of Endocrinology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    World J Surg 26:879-85. 2002
    ..Increasing use of RRA has not apparently improved the already excellent outcome, achieved before 1970, in low risk (MACIS <6) PTC patients managed by near-total thyroidectomy and conservative nodal excision...
  46. ncbi request reprint Higher frequency of diploidy in young-onset microsatellite-stable colorectal cancer
    Lisa A Boardman
    Department of Gastroenterology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Clin Cancer Res 13:2323-8. 2007
    ..The clinicopathologic features of MSS CIN- CRC are not well delineated. We assessed the relationship between age and chromosomal instability (CIN) status as measured by ploidy and allelic imbalance in a series of MSS tumors...
  47. ncbi request reprint Risk of fracture in ulcerative colitis: a population-based study from Olmsted County, Minnesota
    Edward V Loftus
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Clin Gastroenterol Hepatol 1:465-73. 2003
    ..Osteopenia is common in patients with ulcerative colitis (UC), but less is known about fracture risk. Previously we were unable to demonstrate increased fractures in a population-based cohort with Crohn's disease...
  48. ncbi request reprint A potentially deleterious role of IGFBP-2 on bone density in aging men and women
    Shreyasee Amin
    Division of Rheumatology, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Bone Miner Res 19:1075-83. 2004
    ..IGFBP-2, which increases with age in both men and women, was the strongest, most consistent predictor of BMD among the IGF/IGFBPs studied...
  49. ncbi request reprint Contributions of bone density and structure to fracture risk assessment in men and women
    L Joseph Melton
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Osteoporos Int 16:460-7. 2005
    ..Because of the strong correlations, however, some judgment can be used in selecting the variables easiest to measure...
  50. pmc Inherited variants in regulatory T cell genes and outcome of ovarian cancer
    Ellen L Goode
    Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 8:e53903. 2013
    ..1×10(-4)) among all cases combined. As the products of these genes are known to affect induction, trafficking, or immunosuppressive function of Tregs, these results suggest the need for follow-up phenotypic studies...
  51. pmc Genome-wide transcriptional profiling reveals microRNA-correlated genes and biological processes in human lymphoblastoid cell lines
    Liang Wang
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
    PLoS ONE 4:e5878. 2009
    ..However, past studies have focused on the miRNA target genes and used loss- or gain-of-function approach that may not reflect natural association between miRNA and mRNAs...
  52. ncbi request reprint Long-term fracture risk among children with asthma: a population-based study
    L Joseph Melton
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Bone Miner Res 20:564-70. 2005
    ..Fracture risk among patients diagnosed with asthma in childhood is greater in males and oral corticosteroid users, but most fractures are of the appendicular skeleton and may relate to impaired skeletal development...
  53. pmc Phase II trial of lapatinib and topotecan (LapTop) in patients with platinum-refractory/resistant ovarian and primary peritoneal carcinoma
    S John Weroha
    Department of Medical Oncology, Mayo, Rochester, MN 55905, USA
    Gynecol Oncol 122:116-20. 2011
    ..We designed a phase II clinical trial evaluating the efficacy and adverse event profile of concomitant topotecan and lapatinib, a small molecule pan-erbB inhibitor that can block BCRP/Pgp efflux of topotecan...
  54. ncbi request reprint Incidence of childhood distal forearm fractures over 30 years: a population-based study
    Sundeep Khosla
    Endocrine Research Unit, Division of Endocrinology, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minn 55905, USA
    JAMA 290:1479-85. 2003
    ..Changes in physical activity or diet may therefore influence risk of forearm fracture...
  55. ncbi request reprint Role of parathyroid hormone in mediating age-related changes in bone resorption in men
    Kurt A Kennel
    Endocrine Research Unit, Division of Endocrinology, Metabolism and Nutrition, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minn 55905, USA
    Osteoporos Int 14:631-6. 2003
    ..Since both estrogen and testosterone can attenuate the bone resorbing effects of PTH, it is possible that this difference may be due to the much milder degree of sex steroid deficiency in elderly men as compared to postmenopausal women...
  56. pmc Subfractionation, characterization, and in-depth proteomic analysis of glomerular membrane vesicles in human urine
    Marie C Hogan
    Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Kidney Int 85:1225-37. 2014
    ..We calculated sample sizes required to identify new glomerular disease biomarkers, expand the ELV proteome, and provide a reference proteome in a database that may prove useful in the search for biomarkers of glomerular disease. ..
  57. pmc Tumorgrafts as in vivo surrogates for women with ovarian cancer
    S John Weroha
    Authors Affiliations Departments of Oncology, Radiation Oncology, and Molecular Pharmacology and Experimental Therapeutics Department of Health Sciences Research, Division of Biomedical Statistics and Informatics Division of Gynecologic Surgery Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota and Women s Cancer Program, Samuel Oschin Cancer Institute, Cedars Sinai Medical Center, Los Angeles, California
    Clin Cancer Res 20:1288-97. 2014
    ..Ovarian cancer has a high recurrence and mortality rate. A barrier to improved outcomes includes a lack of accurate models for preclinical testing of novel therapeutics...
  58. ncbi request reprint Statistical evaluation of internal and external mass calibration laws utilized in fourier transform ion cyclotron resonance mass spectrometry
    David C Muddiman
    W M Keck FT ICR Mass Spectrometry Laboratory, Mayo Proteomics Research Center and Department of Biochemistry and Molecular Biology, Rochester, Minnesota 55905, USA
    Anal Chem 77:2406-14. 2005
    ..For both our internal and external calibration laws, the median MMA was less than 1 part-per-million. Furthermore, we investigate the number of calibrant ions as well as their required m/z range in order to successfully achieve high MMA...
  59. ncbi request reprint Long-term trends in thyroid carcinoma: a population-based study in Olmsted County, Minnesota, 1935-1999
    James P Burke
    Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Mayo Clin Proc 80:753-8. 2005
    ....
  60. ncbi request reprint Fracture risk with multiple myeloma: a population-based study
    L Joseph Melton
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Bone Miner Res 20:487-93. 2005
    ..Pathologic fractures, especially of the axial skeleton, are extremely common in patients with multiple myeloma and cluster around the time of diagnosis. Osteoporotic fractures seem to be less of a problem in these patients...
  61. ncbi request reprint Long-term fracture risk following renal transplantation: a population-based study
    Line M Vautour
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, Minn, USA
    Osteoporos Int 15:160-7. 2004
    ..Diabetic patients, particularly, experience excess lower limb fractures. Patients and their care providers should be aware of this elevated fracture risk, which continues long-term...
  62. ncbi request reprint Radioactive seed migration to the chest after transperineal interstitial prostate brachytherapy: extraprostatic seed placement correlates with migration
    Jeffrey S Eshleman
    Division of Radiation Oncology, Mayo Clinic, Rochester, MN 55905, USA
    Int J Radiat Oncol Biol Phys 59:419-25. 2004
    ..To examine the incidence of seed migration detected on chest X-ray and to identify the predictors associated with its occurrence...
  63. ncbi request reprint Evaluation of a prediction model for long-term fracture risk
    L Joseph Melton
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Bone Miner Res 20:551-6. 2005
    ..The NOF cost-effectiveness model, based on clinical risk factors and femoral neck aBMD, predicted overall fracture risk in a cohort of postmenopausal women followed for up to 22 years...
  64. ncbi request reprint Effects of duration of type 2 diabetes mellitus on insulin secretion
    Farhad Zangeneh
    Division of Endocrinology, Diabetes, Metabolism, Nutrition, and Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Endocr Pract 12:388-93. 2006
    ..To gain insight into the effects of duration of type 2 diabetes on insulin secretion in patients with type 2 diabetes mellitus...
  65. pmc Fruit and vegetable consumption is inversely associated with having pancreatic cancer
    Rick J Jansen
    Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Cancer Causes Control 22:1613-25. 2011
    ..We used a clinic-based case-control study specifically designed to address limitations of both cohort and case-control studies to examine the relationship...
  66. pmc Folate receptor alpha as a tumor target in epithelial ovarian cancer
    Kimberly R Kalli
    Division of Medical Oncology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Gynecol Oncol 108:619-26. 2008
    ..The goal of this study is to improve historical data that lack specific information about FRalpha expression in rare histological subtypes, primary disease versus metastatic foci, and recurrent disease...
  67. ncbi request reprint Effect of estrogen replacement therapy on parathyroid hormone secretion in elderly postmenopausal women
    Ann Vincent
    Endocrine Research Unit, Division of Endocrinology, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Menopause 10:165-71. 2003
    ..The goal of the present study was to test for these possible direct effects of estrogen on PTH secretion...
  68. ncbi request reprint Fracture risk following bilateral orchiectomy
    L Joseph Melton
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    J Urol 169:1747-50. 2003
    ..Bone loss has been reported in patients with prostate cancer treated with androgen deprivation therapy. We assess fracture risk following bilateral orchiectomy...
  69. ncbi request reprint Fracture risk after bilateral oophorectomy in elderly women
    L Joseph Melton
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    J Bone Miner Res 18:900-5. 2003
    ....
  70. ncbi request reprint Highly methylated genes in colorectal neoplasia: implications for screening
    Hongzhi Zou
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 16:2686-96. 2007
    ..Comethylation of these genes is common, and pursuit of complementary markers for methylation-negative neoplasms is a rational strategy to optimize screening sensitivity...
  71. ncbi request reprint Radiation exposure to operating room personnel during transperineal interstitial permanent prostate brachytherapy
    David J Schwartz
    Division of Radiation Oncology, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Brachytherapy 2:98-102. 2003
    ..To identify factors associated with radiation exposure (RE) to operating room personnel during transperineal interstitial permanent prostate brachytherapy (TIPPB)...
  72. ncbi request reprint Prevalence and predictors of coronary artery calcification in women with polycystic ovary syndrome
    Rose C Christian
    Division of Endocrinology, Metabolism, Diabetes, and Nutrition, Department of Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 88:2562-8. 2003
    ..CAC is more prevalent in PCOS women than in obese or nonobese women of similar age. PCOS women are at increased risk for atherosclerosis and should be targeted for primary prevention of CHD...
  73. pmc Discovery of ovarian cancer biomarkers in serum using NanoLC electrospray ionization TOF and FT-ICR mass spectrometry
    H Robert Bergen
    W M Keck FT ICR Mass Spectrometry Laboratory, Mayo Proteomics Research Center, Rochester, MN, USA
    Dis Markers 19:239-49. 2003
    ..One of these contains the sequence of fibrinopeptide-A known to be elevated in many types of cancer including ovarian cancer. The protocols utilized will be examined and would be applicable to a wide variety of cancers or disease states...
  74. ncbi request reprint Mechanisms of the age-associated deterioration in glucose tolerance: contribution of alterations in insulin secretion, action, and clearance
    Rita Basu
    Endocrine Research Unit, Mayo Medical School, Rochester, Minnesota, USA
    Diabetes 52:1738-48. 2003
    ....
  75. pmc A statistical model for iTRAQ data analysis
    Elizabeth G Hill
    Department of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Proteome Res 7:3091-101. 2008
    ..We demonstrate the model's utility based on an analysis of iTRAQ data derived from a spike-in study...
  76. ncbi request reprint Age- and sex-specific differences in the factor of risk for vertebral fracture: a population-based study using QCT
    Mary L Bouxsein
    Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Bone Miner Res 21:1475-82. 2006
    ..With age, vertebral strength declined and Phi(vert) increased significantly more in women than men. Age- and sex-specific differences in Phi(vert) closely resembled previously reported vertebral fracture incidence...