A Nehra

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. ncbi Medical and surgical advances in the radical prostatectomy patient
    A Nehra
    Department of Urology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Int J Impot Res 12:S47-52. 2000
  2. ncbi Vardenafil improved patient satisfaction with erectile hardness, orgasmic function and sexual experience in men with erectile dysfunction following nerve sparing radical prostatectomy
    Ajay Nehra
    Department of Urology, Mayo Clinic, Rochester, Minnesota, USA
    J Urol 173:2067-71. 2005
  3. pmc Erectile dysfunction and cardiovascular disease: efficacy and safety of phosphodiesterase type 5 inhibitors in men with both conditions
    Ajay Nehra
    Department of Urology, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 84:139-48. 2009
  4. ncbi Selecting therapy for maintaining sexual function in patients with benign prostatic hyperplasia
    Ajay Nehra
    Department of Urology, Mayo Clinic, Rochester, MN 55905, USA
    BJU Int 96:237-43. 2005
  5. ncbi Global perspectives and controversies in the epidemiology of male erectile dysfunction
    Ajay Nehra
    Department of Urology, Mayo Medical School, Rochester, Minnesota 55905, USA
    Curr Opin Urol 12:493-6. 2002
  6. ncbi Intracavernosal therapy: when oral agents fail
    A Nehra
    Department of Urology, Mayo Medical School, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Curr Urol Rep 2:468-72. 2001
  7. ncbi Rationale for combination therapy of intraurethral prostaglandin E(1) and sildenafil in the salvage of erectile dysfunction patients desiring noninvasive therapy
    A Nehra
    Department of Urology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Int J Impot Res 14:S38-42. 2002
  8. ncbi Sildenafil citrate, a selective phosphodiesterase type 5 inhibitor: urologic and cardiovascular implications
    A Nehra
    Mayo Clinic, Rochester, MN 55905, USA
    World J Urol 19:40-5. 2001
  9. ncbi Neurologic erectile dysfunction
    A Nehra
    Department of Urology, Mayo Medical School, and Mayo Clinic and Foundation, Rochester, Minnesota, USA
    Urol Clin North Am 28:289-308. 2001
  10. ncbi Corporeal structural and vascular micro architecture with X-ray micro computerized tomography in normal and diabetic rabbits: histopathological correlation
    D N Simopoulos
    Department of Urology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Urol 165:1776-82. 2001

Detail Information

Publications51

  1. ncbi Medical and surgical advances in the radical prostatectomy patient
    A Nehra
    Department of Urology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Int J Impot Res 12:S47-52. 2000
    ..International Journal of Impotence Research (2000) 12, Suppl 4, S47-S52...
  2. ncbi Vardenafil improved patient satisfaction with erectile hardness, orgasmic function and sexual experience in men with erectile dysfunction following nerve sparing radical prostatectomy
    Ajay Nehra
    Department of Urology, Mayo Clinic, Rochester, Minnesota, USA
    J Urol 173:2067-71. 2005
    ..We report additional parameters important to patient perceptions regarding erection quality and satisfaction with sexual experience following NS-RRP...
  3. pmc Erectile dysfunction and cardiovascular disease: efficacy and safety of phosphodiesterase type 5 inhibitors in men with both conditions
    Ajay Nehra
    Department of Urology, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 84:139-48. 2009
    ..In most studies, PDE5 inhibitors were shown to effectively and safely improve erectile function regardless of cause, severity, or presence of comorbid conditions, including hypertension, diabetes mellitus, and dyslipidemia...
  4. ncbi Selecting therapy for maintaining sexual function in patients with benign prostatic hyperplasia
    Ajay Nehra
    Department of Urology, Mayo Clinic, Rochester, MN 55905, USA
    BJU Int 96:237-43. 2005
    ..Finally, the capacity to be creative in academic departments is extolled as a core property of academicians, and its surfacing described as having the potential to revitalize individuals and departments...
  5. ncbi Global perspectives and controversies in the epidemiology of male erectile dysfunction
    Ajay Nehra
    Department of Urology, Mayo Medical School, Rochester, Minnesota 55905, USA
    Curr Opin Urol 12:493-6. 2002
    ..This perspective discusses the global prevalence and the differences in prevalence on a worldwide basis...
  6. ncbi Intracavernosal therapy: when oral agents fail
    A Nehra
    Department of Urology, Mayo Medical School, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Curr Urol Rep 2:468-72. 2001
    ..Thus, injection therapy remains on the forefront of treatment options...
  7. ncbi Rationale for combination therapy of intraurethral prostaglandin E(1) and sildenafil in the salvage of erectile dysfunction patients desiring noninvasive therapy
    A Nehra
    Department of Urology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Int J Impot Res 14:S38-42. 2002
    ..Although both cAMP- and cGMP-mediated vasodilation can lead to penile erection, combining therapies that incorporate both pathways may succeed when single therapies fail...
  8. ncbi Sildenafil citrate, a selective phosphodiesterase type 5 inhibitor: urologic and cardiovascular implications
    A Nehra
    Mayo Clinic, Rochester, MN 55905, USA
    World J Urol 19:40-5. 2001
    ..FDA approval of sildenafil citrate as the first oral agent for ED in males has resulted in significant interest. We discuss the clinical and pharmacologic properties of sildenafil citrate as well as the urologic and cardiac implications...
  9. ncbi Neurologic erectile dysfunction
    A Nehra
    Department of Urology, Mayo Medical School, and Mayo Clinic and Foundation, Rochester, Minnesota, USA
    Urol Clin North Am 28:289-308. 2001
    ..g., erectile dysfunction after radical retropubic prostatectomy, spinal cord injury, or chronic diseases), a whole-patient approach encompassing psychotherapy is warranted...
  10. ncbi Corporeal structural and vascular micro architecture with X-ray micro computerized tomography in normal and diabetic rabbits: histopathological correlation
    D N Simopoulos
    Department of Urology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Urol 165:1776-82. 2001
    ..These results suggest that 3-D x-ray micro CT with molecular analysis may be a powerful tool for examining the pathophysiology of diabetic erectile dysfunction...
  11. ncbi Functional prostaglandin E (EP) receptors in human penile corpus cavernosum
    R B Moreland
    Department of Urology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Int J Impot Res 15:362-8. 2003
    ..Thus, we suggest that the ultimate response in erectile tissue to various prostanoids is the integration of responses elicited by individual EP receptor subtypes to a given ligand...
  12. ncbi Sleep apnea and cardiovascular disease. Implications for understanding erectile dysfunction
    Adelaide M Arruda-Olson
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Herz 28:298-303. 2003
    ..This review will examine the evidence and potential mechanisms, including abnormalities of neural, endothelial and hormonal function, linking OSA to erectile dysfunction...
  13. ncbi The 'effectiveness' scale--therapeutic outcome of pharmacologic therapies for ED: an international consensus panel report
    C Carson
    Department of Urology, University of North Carolina, Chapel Hill, North Carolina, USA
    Int J Impot Res 16:207-13. 2004
    ..The concept of 'treatment effectiveness' is proposed as a new 'umbrella concept' or distal outcome to be evaluated...
  14. ncbi Cyclin-dependent kinase 5 is expressed in both Sertoli cells and metaphase spermatocytes
    D R Session
    Department of Obstetrics and Gynecology, Mayo Clinic, Minnesota, Rochester 55905, USA
    Fertil Steril 75:669-73. 2001
    ..To gain insight into the function of cyclin-dependent kinase 5 (Cdk5) in spermatogenesis...
  15. pmc The associations between serum sex hormones, erectile function, and sex drive: the Olmsted County Study of Urinary Symptoms and Health Status among Men
    Naomi M Gades
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, USA
    J Sex Med 5:2209-20. 2008
    ..Testosterone replacement therapy has been used in the treatment of sexual dysfunction; however, its use remains controversial, and the effectiveness and long-term health implications are unknown...
  16. ncbi Prognostic value of p53 and MIB-1 in transitional cell carcinoma of the urinary bladder with regional lymph node involvement
    Igor Frank
    Department of Urology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer 101:1803-8. 2004
    ..The objective of this study was to assess the ability of these markers to predict disease-associated outcomes and response to chemotherapy in a cohort of patients with LN-positive TCC...
  17. ncbi Transitional cell carcinoma of the urinary bladder with regional lymph node involvement treated by cystectomy: clinicopathologic features associated with outcome
    Igor Frank
    Department of Urology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer 97:2425-31. 2003
    ..However, some patients are cured by radical cystectomy alone. The goal of this study was to identify predictors of survival in this cohort...
  18. pmc Presumed circle area ratio of the prostate in a community-based group of men
    Jennifer L St Sauver
    Mayo Clinic, Department of Health Sciences Research, Division of Epidemiology, Rochester, MN, USA
    BJU Int 104:58-62. 2009
    ..95, 95% confidence interval 1.39-6.25, and 3.47, 1.63-7.39, respectively). CONCLUSION PCAR might add further information beyond total prostate volume when predicting the development of obstructive LUTS...
  19. pmc Associations between C-reactive protein and benign prostatic hyperplasia/lower urinary tract symptom outcomes in a population-based cohort
    Jennifer L St Sauver
    Division of Epidemiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Am J Epidemiol 169:1281-90. 2009
    ..00, 95% CI: 1.04, 3.82; peak flow rate: OR = 2.45, 95% CI: 0.73, 8.25). These results suggest that rapid increases in irritative LUTS and rapid decreases in peak flow rates may be due to inflammatory processes...
  20. ncbi DHEA in elderly women and DHEA or testosterone in elderly men
    K Sreekumaran Nair
    Division of Endocrinology, Mayo Clinic, Rochester, MN 55905, USA
    N Engl J Med 355:1647-59. 2006
    ..Dehydroepiandrosterone (DHEA) and testosterone are widely promoted as antiaging supplements, but the long-term benefits, as compared with potential harm, are unknown...
  21. ncbi Combination therapy for erectile dysfunction: where we are and what's in the future
    Ajay Nehra
    Department of Urology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Curr Urol Rep 3:467-70. 2002
    ..The rationale for and recent reports on combination therapy are presented in this review...
  22. pmc Smoking and acute urinary retention: the Olmsted County study of urinary symptoms and health status among men
    Aruna V Sarma
    Department of Urology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0759, USA
    Prostate 69:699-705. 2009
    ..We hypothesized that acute urinary retention (AUR), an adverse outcome of this disease and indication for surgical treatment, may be related to smoking...
  23. pmc Longitudinal evaluation of sexual function in a male cohort: the Olmsted county study of urinary symptoms and health status among men
    Naomi M Gades
    Division of Epidemiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Sex Med 6:2455-66. 2009
    ..Long-term data showing how changes in multiple sexual function domains track together may be useful in understanding the importance of physical declines vs. sexual satisfaction...
  24. ncbi Cardiovascular effects of sildenafil during exercise in men with known or probable coronary artery disease: a randomized crossover trial
    Adelaide M Arruda-Olson
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    JAMA 287:719-25. 2002
    ..The relationship between sildenafil citrate use and reported adverse cardiovascular events in men with coronary artery disease (CAD) is unclear...
  25. ncbi Association between smoking and erectile dysfunction: a population-based study
    Naomi M Gades
    Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Am J Epidemiol 161:346-51. 2005
    ..00, 2.02), and there was a dose response. Although the causal pathway underlying this association is not clear, this study contributes to the growing literature describing an association between smoking and erectile dysfunction...
  26. ncbi The physiology of erectile dysfunction
    Shane Russell
    Department of Urology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Herz 28:277-83. 2003
    ....
  27. ncbi Lower extremity above-knee prosthesis-associated erectile dysfunction
    R Munarriz
    Boston University School of Medicine, Department of Urology, Massachusetts, USA
    Int J Impot Res 15:290-2. 2003
    ..Further research is needed in above-knee prosthesis design to prevent erectile dysfunction...
  28. ncbi Potassium outward currents in freshly dissociated rabbit corpus cavernosum myocytes
    J Malysz
    Division of Gastroenterology and Hepatology, Mayo Foundation/Mayo Clinic, Rochester, Minnesota, USA
    J Urol 166:1167-77. 2001
    ..The activation threshold suggests that delayed rectifier K+ channels are open at the resting membrane potential and, therefore, contribute to control and regulation of the cavernous myocyte excitability...
  29. ncbi Erectile dysfunction and cardiovascular disease
    Shane T Russell
    Department of Urology, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Mayo Clin Proc 79:782-94. 2004
    ..The risks of sexual activity for patients with cardiovascular disease are discussed, as are prevention and treatment strategies for ED in this patient population...
  30. ncbi Clinical evaluation of erectile dysfunction in the era of PDE-5 inhibitors
    John R Lobo
    Department of Urology, Mayo Clinic, Rochester, MN 55905, USA
    Urol Clin North Am 32:447-55, vi. 2005
    ....
  31. ncbi Review of erectile dysfunction and cardiovascular risk
    A Nehra
    Department of Urology, Rush University Medical Center, 60612 Chicago, IL, USA
    Minerva Urol Nefrol 65:109-15. 2013
    ..We advocate using ED as risk for future CVD events, and review the current literature for the management of ED and CVD...
  32. ncbi Report of the American Foundation for Urologic Disease (AFUD) Thought Leader Panel for evaluation and treatment of priapism
    R Berger
    Department of Urology, Boston University School of Medicine, MA 02118, USA
    Int J Impot Res 13:S39-43. 2001
    ..Critical areas to be addressed include the multiple pathophysiologies of priapism as well as multi-institutional trials to objectively assess safety and efficacy in the various treatment modalities...
  33. ncbi Expression of functional prostaglandin D (DP) receptors in human corpus cavernosum smooth muscle
    R B Moreland
    Department of Urology, Boston University School of Medicine, Boston, Massachusetts, USA
    Int J Impot Res 14:446-52. 2002
    ..These data are consistent with the expression of functional DP receptors in human corpus cavernosum. This suggests the presence of an intact prostanoid autocrine system that may play a role in regulating penile erectile function...
  34. ncbi Dual implantation of penile and sphincter implants in the post-prostatectomy patient
    Rajeev Kumar
    Department of Urology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Curr Urol Rep 8:477-81. 2007
    ..In this manuscript, we review the indications, techniques, merits, and safety of simultaneous dual implantation of the artificial urinary sphincter and penile prosthesis in the post-radical prostatectomy patient...
  35. ncbi Single-blind, multicenter, placebo controlled, parallel study to assess the safety and efficacy of intralesional interferon alpha-2B for minimally invasive treatment for Peyronie's disease
    Wayne J G Hellstrom
    Department of Urology, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    J Urol 176:394-8. 2006
    ..We investigated the efficacy and safety of intralesional interferon alpha-2b for the treatment of Peyronie's disease...
  36. ncbi Diabetes and sexual dysfunction: results from the Olmsted County study of urinary symptoms and health status among men
    James P Burke
    Division of Epidemiology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    J Urol 177:1438-42. 2007
    ..We examined the association of diabetes and domains of sexual dysfunction in a population based sample of men residing in Olmsted County, Minnesota...
  37. doi Pharmacoangiographic evidence of the presence and anatomical dominance of accessory pudendal artery(s)
    Ajay Nehra
    Department of Urology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    J Urol 179:2317-20. 2008
    ..We reviewed pudendal angiograms in patients with erectile dysfunction to evaluate the prevalence and importance of these vessels...
  38. ncbi The Kv2.2 alpha subunit contributes to delayed rectifier K(+) currents in myocytes from rabbit corpus cavernosum
    John Malysz
    Department of Physiology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Androl 23:899-910. 2002
    ..We conclude that Kv2.2 alpha subunits contribute to whole-cell currents in rabbit canvernosal myocytes. Further, K(v) currents play a role in regulating membrane potential and hence excitability in rabbit cavernosal myocytes...
  39. pmc The association between statin use and the diagnosis of prostate cancer in a population based cohort
    Rodney H Breau
    Department of Urology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    J Urol 184:494-9. 2010
    ..The effect of statin medication use on the risk of prostate cancer is unknown...
  40. doi Priapism: pathogenesis, epidemiology, and management
    Gregory A Broderick
    Department of Urology, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    J Sex Med 7:476-500. 2010
    ..A correct diagnosis of priapism is a matter of urgency requiring identification of underlying hemodynamics...
  41. ncbi Application of vacuum-assisted closure dressing in penile skin graft reconstruction
    Alex Senchenkov
    Department of Plastic and Reconstructive Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Urology 67:416-9. 2006
    ..Skin grafting of penile defects is difficult because of the flexibility of the underlying recipient bed. This leads to disruption of the vascular ingrowth into the skin graft and compromises the results of the reconstruction...
  42. ncbi Lower urinary tract symptoms and sexual dysfunction in community-dwelling men
    Woo Sik Chung
    Department of Urology, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Mayo Clin Proc 79:745-9. 2004
    ..To evaluate the cross-sectional association between lower urinary tract symptoms (LUTS) severity and sexual function in a population-based sample of men and the extent to which this association might be explained by age...
  43. ncbi Safety and efficacy of vardenafil for the treatment of men with erectile dysfunction after radical retropubic prostatectomy
    Gerald Brock
    St Joseph s Medical Center, Lawson Research Institute, London, Ontario, Canada
    J Urol 170:1278-83. 2003
    ..The efficacy and safety of vardenafil, a potent, selective, phosphodiesterase 5 inhibitor, was assessed for the treatment of ED after radical prostatectomy...
  44. ncbi The efficacy of sildenafil citrate (Viagra) in clinical populations: an update
    Culley C Carson
    Department of Surgery, Division of Urology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7235, USA
    Urology 60:12-27. 2002
    ..Findings from published accounts of sildenafil use in the clinical practice setting further demonstrated that sildenafil is an effective treatment for a wide range of patients with ED...
  45. doi Effect of sildenafil citrate (Viagra) on coronary flow in normal subjects
    Fuminobu Ishikura
    School of Allied Health Sciences, Osaka University, Faculty of Medicine, Osaka, Japan
    Echocardiography 25:72-6. 2008
    ..The purpose of this study was to evaluate the effect of sildenafil citrate (Viagra) on coronary function in normal subjects...
  46. ncbi Pharmacotherapy for erectile dysfunction
    Harin Padma-Nathan
    J Sex Med 1:128-40. 2004
    ..Advances in understanding of the biochemistry and physiology of penile erection have led to breakthroughs in pharmacotherapy of erectile dysfunction...
  47. ncbi American Urological Association guideline on the management of priapism
    Drogo K Montague
    J Urol 170:1318-24. 2003
  48. doi Re: "Cigarette smoking and erectile dysfunction among Chinese men without clinical vascular disease"
    Naomi M Gades
    Am J Epidemiol 167:882; author reply 882-3. 2008
  49. ncbi Chapter 1: The management of erectile dysfunction: an AUA update
    Drogo K Montague
    J Urol 174:230-9. 2005
  50. ncbi Sexual dysfunction and cardiac risk (the Second Princeton Consensus Conference)
    John B Kostis
    University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
    Am J Cardiol 96:85M-93M. 2005
    ..Finally, further research on the role of PDE-5 inhibition in treating patients with other medical or cardiovascular disorders is recommended...
  51. ncbi Sexual dysfunction and cardiac risk (the Second Princeton Consensus Conference)
    John B Kostis
    University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ, USA
    Am J Cardiol 96:313-21. 2005
    ..Finally, further research on the role of PDE-5 inhibition in treating patients with other medical or cardiovascular disorders is recommended...