Brian M Necela

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. ncbi Toll-like receptor 4 mediates cross-talk between peroxisome proliferator-activated receptor gamma and nuclear factor-kappaB in macrophages
    Brian M Necela
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, FL 32224, USA
    Immunology 125:344-58. 2008
  2. ncbi Peroxisome proliferator-activated receptor gamma down-regulates follistatin in intestinal epithelial cells through SP1
    Brian M Necela
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida 32224, USA
    J Biol Chem 283:29784-94. 2008
  3. ncbi Peroxisome proliferator-activated receptor gamma promotes epithelial to mesenchymal transformation by Rho GTPase-dependent activation of ERK1/2
    Lu Chen
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida 32224, USA
    J Biol Chem 281:24575-87. 2006
  4. ncbi Differential expression, distribution, and function of PPAR-gamma in the proximal and distal colon
    Weidong Su
    Department of Cancer Biology, Mayo Clinic College of Medicine, Jacksonville, Florida 32225, USA
    Physiol Genomics 30:342-53. 2007
  5. ncbi The high affinity peroxisome proliferator-activated receptor-gamma agonist RS5444 inhibits both initiation and progression of colon tumors in azoxymethane-treated mice
    Weidong Su
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, FL 32224, USA
    Int J Cancer 123:991-7. 2008
  6. ncbi RS5444, a novel PPARgamma agonist, regulates aspects of the differentiated phenotype in nontransformed intestinal epithelial cells
    Lu Chen
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, 4500 San Pablo Road, Griffin Cancer Research Bldg, Rm 310, Jacksonville, FL 32224, USA
    Mol Cell Endocrinol 251:17-32. 2006
  7. ncbi MicroRNA signatures: clinical biomarkers for the diagnosis and treatment of breast cancer
    Cathy A Andorfer
    Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Trends Mol Med 17:313-9. 2011
  8. ncbi Differential expression of microRNAs in tumors from chronically inflamed or genetic (APC(Min/+)) models of colon cancer
    Brian M Necela
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida, United States of America
    PLoS ONE 6:e18501. 2011
  9. ncbi Pathophysiological Roles of PPARgamma in Gastrointestinal Epithelial Cells
    Brian M Necela
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, FL 32224, USA
    PPAR Res 2008:148687. 2008

Collaborators

  • E Aubrey Thompson
  • Panos Z Anastasiadis
  • Weidong Su
  • Alan P Fields
  • Lu Chen
  • Cathy A Andorfer
  • Nicole R Murray
  • Craig R Bush
  • Masahiro Yanagisawa
  • Edith A Perez
  • Kosaku Fujiwara
  • Shinichi Kurakata
  • Shelly R Calcagno

Detail Information

Publications9

  1. ncbi Toll-like receptor 4 mediates cross-talk between peroxisome proliferator-activated receptor gamma and nuclear factor-kappaB in macrophages
    Brian M Necela
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, FL 32224, USA
    Immunology 125:344-58. 2008
    ....
  2. ncbi Peroxisome proliferator-activated receptor gamma down-regulates follistatin in intestinal epithelial cells through SP1
    Brian M Necela
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida 32224, USA
    J Biol Chem 283:29784-94. 2008
    ..Collectively, our data indicate that repression of Sp1 transcriptional activity by PPARgamma is the underlying mechanism responsible for PPARgamma-mediated regulation of follistatin expression...
  3. ncbi Peroxisome proliferator-activated receptor gamma promotes epithelial to mesenchymal transformation by Rho GTPase-dependent activation of ERK1/2
    Lu Chen
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida 32224, USA
    J Biol Chem 281:24575-87. 2006
    ....
  4. ncbi Differential expression, distribution, and function of PPAR-gamma in the proximal and distal colon
    Weidong Su
    Department of Cancer Biology, Mayo Clinic College of Medicine, Jacksonville, Florida 32225, USA
    Physiol Genomics 30:342-53. 2007
    ....
  5. ncbi The high affinity peroxisome proliferator-activated receptor-gamma agonist RS5444 inhibits both initiation and progression of colon tumors in azoxymethane-treated mice
    Weidong Su
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, FL 32224, USA
    Int J Cancer 123:991-7. 2008
    ..We conclude that RS5444 inhibits both initiation and progression of colon tumors in the AOM model of sporadic colon carcinogenesis...
  6. ncbi RS5444, a novel PPARgamma agonist, regulates aspects of the differentiated phenotype in nontransformed intestinal epithelial cells
    Lu Chen
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, 4500 San Pablo Road, Griffin Cancer Research Bldg, Rm 310, Jacksonville, FL 32224, USA
    Mol Cell Endocrinol 251:17-32. 2006
    ..Many nuclear receptors regulate differentiation. However, our results point to novel effects of PPARgamma on cell-cell and cell-matrix interactions, which are not typical of other nuclear receptors...
  7. ncbi MicroRNA signatures: clinical biomarkers for the diagnosis and treatment of breast cancer
    Cathy A Andorfer
    Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Trends Mol Med 17:313-9. 2011
    ..In this review, we discuss the use of miRNA signatures for breast cancer treatment and discuss the challenges in the field...
  8. ncbi Differential expression of microRNAs in tumors from chronically inflamed or genetic (APC(Min/+)) models of colon cancer
    Brian M Necela
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida, United States of America
    PLoS ONE 6:e18501. 2011
    ..The aim of these studies was to identify microRNAs that are aberrantly regulated during inflammation and may participate in transformation of colonic epithelial cells in the inflammatory setting...
  9. ncbi Pathophysiological Roles of PPARgamma in Gastrointestinal Epithelial Cells
    Brian M Necela
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, FL 32224, USA
    PPAR Res 2008:148687. 2008
    ....