Brian M Necela

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Toll-like receptor 4 mediates cross-talk between peroxisome proliferator-activated receptor gamma and nuclear factor-kappaB in macrophages
    Brian M Necela
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, FL 32224, USA
    Immunology 125:344-58. 2008
  2. pmc Peroxisome proliferator-activated receptor gamma down-regulates follistatin in intestinal epithelial cells through SP1
    Brian M Necela
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida 32224, USA
    J Biol Chem 283:29784-94. 2008
  3. ncbi request reprint Peroxisome proliferator-activated receptor gamma promotes epithelial to mesenchymal transformation by Rho GTPase-dependent activation of ERK1/2
    Lu Chen
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida 32224, USA
    J Biol Chem 281:24575-87. 2006
  4. ncbi request reprint Differential expression, distribution, and function of PPAR-gamma in the proximal and distal colon
    Weidong Su
    Department of Cancer Biology, Mayo Clinic College of Medicine, Jacksonville, Florida 32225, USA
    Physiol Genomics 30:342-53. 2007
  5. pmc The high affinity peroxisome proliferator-activated receptor-gamma agonist RS5444 inhibits both initiation and progression of colon tumors in azoxymethane-treated mice
    Weidong Su
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, FL 32224, USA
    Int J Cancer 123:991-7. 2008
  6. ncbi request reprint RS5444, a novel PPARgamma agonist, regulates aspects of the differentiated phenotype in nontransformed intestinal epithelial cells
    Lu Chen
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, 4500 San Pablo Road, Griffin Cancer Research Bldg, Rm 310, Jacksonville, FL 32224, USA
    Mol Cell Endocrinol 251:17-32. 2006
  7. pmc Gene expression, single nucleotide variant and fusion transcript discovery in archival material from breast tumors
    Nadine Norton
    Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America
    PLoS ONE 8:e81925. 2013
  8. pmc RNA sequencing identifies multiple fusion transcripts, differentially expressed genes, and reduced expression of immune function genes in BRAF (V600E) mutant vs BRAF wild-type papillary thyroid carcinoma
    Robert C Smallridge
    Department of Medicine R C S, Division of Endocrinology and Metabolism, Mayo Clinic, Jacksonville, Florida 32224 Department of Otorhinolaryngology Head and Neck Surgery A M C, J D C, Mayo Clinic, Jacksonville, Florida 32224 Department of Health Sciences Research Y W A, D J S, Mayo Clinic, Jacksonville, Florida 32224 Department of Medicine, Division of Endocrinology H V R, N L E, B M, Mayo Clinic, Rochester, Minnesota 55905 Department of Laboratory Medicine and Pathology K W C, S K G, Division of Clinical Biochemistry and Immunology, Mayo Clinic, Rochester, Minnesota 55905 Department of Laboratory Medicine and Pathology M R, Division of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota 55905 Department of Cancer Biology B N, J M C, J A C, E A T, Mayo Clinic, Jacksonville, Florida 32224 and Department of Biochemistry and Molecular Biology N L E, Mayo Clinic, Rochester, Minnesota 55905
    J Clin Endocrinol Metab 99:E338-47. 2014
  9. doi request reprint MicroRNA signatures: clinical biomarkers for the diagnosis and treatment of breast cancer
    Cathy A Andorfer
    Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Trends Mol Med 17:313-9. 2011
  10. pmc Differential expression of microRNAs in tumors from chronically inflamed or genetic (APC(Min/+)) models of colon cancer
    Brian M Necela
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida, United States of America
    PLoS ONE 6:e18501. 2011

Collaborators

Detail Information

Publications11

  1. pmc Toll-like receptor 4 mediates cross-talk between peroxisome proliferator-activated receptor gamma and nuclear factor-kappaB in macrophages
    Brian M Necela
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, FL 32224, USA
    Immunology 125:344-58. 2008
    ....
  2. pmc Peroxisome proliferator-activated receptor gamma down-regulates follistatin in intestinal epithelial cells through SP1
    Brian M Necela
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida 32224, USA
    J Biol Chem 283:29784-94. 2008
    ..Collectively, our data indicate that repression of Sp1 transcriptional activity by PPARgamma is the underlying mechanism responsible for PPARgamma-mediated regulation of follistatin expression...
  3. ncbi request reprint Peroxisome proliferator-activated receptor gamma promotes epithelial to mesenchymal transformation by Rho GTPase-dependent activation of ERK1/2
    Lu Chen
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida 32224, USA
    J Biol Chem 281:24575-87. 2006
    ....
  4. ncbi request reprint Differential expression, distribution, and function of PPAR-gamma in the proximal and distal colon
    Weidong Su
    Department of Cancer Biology, Mayo Clinic College of Medicine, Jacksonville, Florida 32225, USA
    Physiol Genomics 30:342-53. 2007
    ....
  5. pmc The high affinity peroxisome proliferator-activated receptor-gamma agonist RS5444 inhibits both initiation and progression of colon tumors in azoxymethane-treated mice
    Weidong Su
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, FL 32224, USA
    Int J Cancer 123:991-7. 2008
    ..We conclude that RS5444 inhibits both initiation and progression of colon tumors in the AOM model of sporadic colon carcinogenesis...
  6. ncbi request reprint RS5444, a novel PPARgamma agonist, regulates aspects of the differentiated phenotype in nontransformed intestinal epithelial cells
    Lu Chen
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, 4500 San Pablo Road, Griffin Cancer Research Bldg, Rm 310, Jacksonville, FL 32224, USA
    Mol Cell Endocrinol 251:17-32. 2006
    ..Many nuclear receptors regulate differentiation. However, our results point to novel effects of PPARgamma on cell-cell and cell-matrix interactions, which are not typical of other nuclear receptors...
  7. pmc Gene expression, single nucleotide variant and fusion transcript discovery in archival material from breast tumors
    Nadine Norton
    Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America
    PLoS ONE 8:e81925. 2013
    ..The RiboZeroGold ScriptSeq protocol performed particularly well for lincRNA expression from FFPE libraries, but detection of eSNV and fusion transcripts was less sensitive. ..
  8. pmc RNA sequencing identifies multiple fusion transcripts, differentially expressed genes, and reduced expression of immune function genes in BRAF (V600E) mutant vs BRAF wild-type papillary thyroid carcinoma
    Robert C Smallridge
    Department of Medicine R C S, Division of Endocrinology and Metabolism, Mayo Clinic, Jacksonville, Florida 32224 Department of Otorhinolaryngology Head and Neck Surgery A M C, J D C, Mayo Clinic, Jacksonville, Florida 32224 Department of Health Sciences Research Y W A, D J S, Mayo Clinic, Jacksonville, Florida 32224 Department of Medicine, Division of Endocrinology H V R, N L E, B M, Mayo Clinic, Rochester, Minnesota 55905 Department of Laboratory Medicine and Pathology K W C, S K G, Division of Clinical Biochemistry and Immunology, Mayo Clinic, Rochester, Minnesota 55905 Department of Laboratory Medicine and Pathology M R, Division of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota 55905 Department of Cancer Biology B N, J M C, J A C, E A T, Mayo Clinic, Jacksonville, Florida 32224 and Department of Biochemistry and Molecular Biology N L E, Mayo Clinic, Rochester, Minnesota 55905
    J Clin Endocrinol Metab 99:E338-47. 2014
    ..The BRAF V600E mutation (BRAF-MUT) confers an aggressive phenotype in papillary thyroid carcinoma, but unidentified additional genomic abnormalities may be required for full phenotypic expression...
  9. doi request reprint MicroRNA signatures: clinical biomarkers for the diagnosis and treatment of breast cancer
    Cathy A Andorfer
    Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Trends Mol Med 17:313-9. 2011
    ..In this review, we discuss the use of miRNA signatures for breast cancer treatment and discuss the challenges in the field...
  10. pmc Differential expression of microRNAs in tumors from chronically inflamed or genetic (APC(Min/+)) models of colon cancer
    Brian M Necela
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida, United States of America
    PLoS ONE 6:e18501. 2011
    ..The aim of these studies was to identify microRNAs that are aberrantly regulated during inflammation and may participate in transformation of colonic epithelial cells in the inflammatory setting...
  11. pmc Pathophysiological Roles of PPARgamma in Gastrointestinal Epithelial Cells
    Brian M Necela
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, FL 32224, USA
    PPAR Res 2008:148687. 2008
    ....