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Genomes and Genes | Samih H NasrSummaryAffiliation: Mayo Clinic Country: USA Publications
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Publications
Proliferative glomerulonephritis with monoclonal IgG deposits recurs in the allograftSamih H Nasr
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
Clin J Am Soc Nephrol 6:122-32. 2011..Proliferative GN with monoclonal IgG deposits (PGNMID) is a newly described entity resembling immune complex GN. Its potential to recur in the allograft is undefined...
Myeloproliferative neoplasms cause glomerulopathySamar M Said
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
Kidney Int 80:753-9. 2011..Greater awareness of this entity and larger studies are needed to define possible therapies...- Acquired glomerular lesions in patients with Down syndromeSamar M Said
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
Hum Pathol 43:81-8. 2012..Renal biopsy is necessary to determine the type of glomerular lesion and appropriate treatment... - The diagnosis and characteristics of renal heavy-chain and heavy/light-chain amyloidosis and their comparison with renal light-chain amyloidosisSamih H Nasr
Department of Laboratory Medicine and Pathology, Mayo Clinic, Division of Anatomic Pathology, Hilton 10 20 200 First Street, SW, Rochester, Minnesota 55905, USA
Kidney Int 83:463-70. 2013..The accurate histological diagnosis of renal AH/AHL and distinction from AL may have important clinical and prognostic implications... - Immunotactoid glomerulopathy: clinicopathologic and proteomic studySamih H Nasr
Correspondence and offprint requests to Samih H Nasr E mail
Nephrol Dial Transplant 27:4137-46. 2012..The proteomic profile of ITG is consistent with deposition of monotypic immunoglobulins and activation of the classical and terminal pathway of complement... - Clinicopathologic correlations in multiple myeloma: a case series of 190 patients with kidney biopsiesSamih H Nasr
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
Am J Kidney Dis 59:786-94. 2012..Renal involvement is common in multiple myeloma. In this study, we examined kidney biopsy findings in patients with multiple myeloma and correlated them with their clinical renal and hematologic characteristics... - Renal monoclonal immunoglobulin deposition disease: a report of 64 patients from a single institutionSamih H Nasr
Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Hilton 10 20, Rochester, MN 55905, USA
Clin J Am Soc Nephrol 7:231-9. 2012..To better define the clinical-pathologic spectrum and prognosis of monoclonal immunoglobulin deposition disease (MIDD), this study reports the largest series... - Crystalline nephropathy due to 2,8-dihydroxyadeninuria: an under-recognized cause of irreversible renal failureSamih H Nasr
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
Nephrol Dial Transplant 25:1909-15. 2010..Only rare cases of DHA nephrolithiasis have been reported from the USA. Herein, we report three American patients who developed DHA crystalline nephropathy leading to end-stage renal disease (ESRD) with recurrence in the allograft... - IgA-dominant postinfectious glomerulonephritis: a new twist on an old diseaseSamih H Nasr
Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Nephron Clin Pract 119:c18-25; discussion c26. 2011..The pathogenetic mechanism of selective IgA deposition in patients with poststaphylococcal glomerulonephritis likely involves specific host responses to the inciting pathogen... - Fibrillary glomerulonephritis: a report of 66 cases from a single institutionSamih H Nasr
Mayo Clinic, Division of Anatomic Pathology, Hilton 10 20, 200 First Street SW, Rochester, MN 55905, USA
Clin J Am Soc Nephrol 6:775-84. 2011..Most previously reported cases were idiopathic. To better define the clinical-pathologic spectrum and prognosis, we report the largest single-center series with the longest follow-up... - Postinfectious glomerulonephritis in the elderlySamih H Nasr
Mayo Clinic, Division of Anatomic Pathology, Hilton 10 20, 200 First Street, SW, Rochester, MN 55905, USA
J Am Soc Nephrol 22:187-95. 2011..Prognosis for these older patients is poor, with fewer than 25% recovering full renal function... - Laser microdissection and mass spectrometry-based proteomics aids the diagnosis and typing of renal amyloidosisSanjeev Sethi
Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
Kidney Int 82:226-34. 2012.... - Mass spectrometry-based proteomic diagnosis of renal immunoglobulin heavy chain amyloidosisSanjeev Sethi
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
Clin J Am Soc Nephrol 5:2180-7. 2010..We also describe the clinicopathologic findings of four problematic cases of renal Ig heavy chain amyloidosis that required LMD/MS proteomic analysis for accurate typing of the amyloid... - Urinary albumin excretion patterns of patients with cast nephropathy and other monoclonal gammopathy-related kidney diseasesNelson Leung
Division of Hematology, Mayo Clinic, Rochester, Minnesota 55901, USA
Clin J Am Soc Nephrol 7:1964-8. 2012.... - C1q deposition in the renal allograft: a report of 24 casesSamar M Said
Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
Mod Pathol 23:1080-8. 2010..The rate of preceding infection and the prevalence of proteinuria seem to be similar to the renal transplant recipients in general. Most cases show mesangial hypercellularity or no glomerular changes on light microscopy... - Clinical features of patients with immunoglobulin light chain amyloidosis (AL) with vascular-limited deposition in the kidneyAlfonso Eirin
Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA
Nephrol Dial Transplant 27:1097-101. 2012..There was a preference for λ light chain in the D-AL that was not noted in the V-AL. Patients with D-AL in this study had a longer median survival but most of them were stem cell transplantation candidates... - Membranous glomerulonephritis is a manifestation of IgG4-related diseaseMariam P Alexander
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA
Kidney Int 83:455-62. 2013..4 mg/dl). Thus, MGN should be included in the spectrum of IgG4-RD and should be suspected in proteinuric IgG4-RD patients. Conversely, patients with MGN and an appropriate clinical history should be evaluated for IgG4-RD... - Monoclonal gammopathy of renal significance: when MGUS is no longer undetermined or insignificantNelson Leung
Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA
Blood 120:4292-5. 2012.... 
C3 glomerulonephritis: clinicopathological findings, complement abnormalities, glomerular proteomic profile, treatment, and follow-upSanjeev Sethi
Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
Kidney Int 82:465-73. 2012..Thus, C3GN results from diverse abnormalities of the alternative complement pathway leading to subsequent glomerular injury...- Atypical postinfectious glomerulonephritis is associated with abnormalities in the alternative pathway of complementSanjeev Sethi
Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
Kidney Int 83:293-9. 2013..Hence, the sequela is continual glomerular deposition of complement factors with resultant inflammation and development of an 'atypical' postinfectious glomerulonephritis... - How I treat amyloidosis: the importance of accurate diagnosis and amyloid typingNelson Leung
Division of Nephrology and Hypertension, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
Blood 120:3206-13. 2012.... - Proliferative glomerulonephritis secondary to dysfunction of the alternative pathway of complementSanjeev Sethi
Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
Clin J Am Soc Nephrol 6:1009-17. 2011..A recently described entity referred to as GN with C3 deposition (GN-C3) bears many similarities to DDD. The purpose of this study was to evaluate AP function in cases of GN-C3... - Low- and high-molecular-weight urinary proteins as predictors of response to rituximab in patients with membranous nephropathy: a prospective studyMaria V Irazabal
Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, MN, USA
Nephrol Dial Transplant 28:137-46. 2013..Selective urinary biomarkers have been considered superior to total proteinuria in predicting response to treatment and outcome in patients with membranous nephropathy (MN)... - Renal crescentic alpha heavy chain deposition disease: a report of 3 cases and review of the literatureMariam P Alexander
Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
Am J Kidney Dis 58:621-5. 2011..In this report, we describe 3 additional cases of α HCDD, all with a crescentic pattern of injury and one of which was associated with cutis laxa. We compare their clinicopathologic features with all previously reported cases of HCDD... - A novel mutation of LAMB2 in a multigenerational mennonite family reveals a new phenotypic variant of Pierson syndromeBrian G Mohney
Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905, USA
Ophthalmology 118:1137-44. 2011..To describe a novel laminin β-2 (LAMB2) mutation associated with nephrotic syndrome and severe retinal disease without microcoria in a large, multigenerational family with Pierson syndrome... - Diagnosis of IgG4-related tubulointerstitial nephritisYassaman Raissian
Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 1 Street SW, Rochester, MN 55905, USA
J Am Soc Nephrol 22:1343-52. 2011..When the disease manifests in the kidney, our data support diagnostic criteria that can distinguish IgG4-TIN from other types of TIN... - Bacterial infection-related glomerulonephritis in adultsSamih H Nasr
Department of Laboratory Medicine and Pathology, Division of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota, USA
Kidney Int 83:792-803. 2013..This review will address the current status of sporadic bacterial IRGN in adults... - Functional polycystin-1 dosage governs autosomal dominant polycystic kidney disease severityKatharina Hopp
Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA
J Clin Invest 122:4257-73. 2012..Altogether, this study highlights the role that in trans variants at the disease locus can play in phenotypic modification of dominant diseases and provides a truly orthologous PKD1 model, optimal for therapeutic testing... - Myoglobin-associated acute kidney injury in the setting of ciprofloxacin administrationQi Qian
Department of Medicine, Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Am J Kidney Dis 59:462-6. 2012..We present a case of myoglobin-associated kidney failure in the setting of repeated ciprofloxacin administration in a lung transplant patient. Kidney biopsy was critical to establishing the diagnosis and avoiding future exposure...