K SREEKKUMARAN NAIR

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. ncbi request reprint Aging muscle
    K Sreekumaran Nair
    Mayo Clinic College of Medicine, Division of Endocrinology and Endocrine Research, Rochester, MN 55905, USA
    Am J Clin Nutr 81:953-63. 2005
  2. pmc Age, obesity, and sex effects on insulin sensitivity and skeletal muscle mitochondrial function
    Helen Karakelides
    Division of Endocrinology, Endocrinology Research Unit, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Diabetes 59:89-97. 2010
  3. pmc The effect of high glucocorticoid administration and food restriction on rodent skeletal muscle mitochondrial function and protein metabolism
    Y Nancy You
    Endocrine Research Unit, Mayo Clinic College of Medicine, Rochester, MN, USA
    PLoS ONE 4:e5283. 2009
  4. pmc Quantitative metabolomics by H-NMR and LC-MS/MS confirms altered metabolic pathways in diabetes
    Ian R Lanza
    Endocrinology Research Unit, Division of Endocrinology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
    PLoS ONE 5:e10538. 2010
  5. pmc Identification of de novo synthesized and relatively older proteins: accelerated oxidative damage to de novo synthesized apolipoprotein A-1 in type 1 diabetes
    Abdul Jaleel
    Division of Endocrinology, Mayo Clinic, Rochester, Minnesota, USA
    Diabetes 59:2366-74. 2010
  6. pmc Function-based discovery of significant transcriptional temporal patterns in insulin stimulated muscle cells
    Barbara Di Camillo
    Information Engineering Department, University of Padova, Padova, Italy
    PLoS ONE 7:e32391. 2012
  7. pmc Effect of testosterone on insulin stimulated IRS1 Ser phosphorylation in primary rat myotubes--a potential model for PCOS-related insulin resistance
    Michael C Allemand
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Mayo Clinic Graduate School of Medicine, Rochester, Minnesota, United States of America
    PLoS ONE 4:e4274. 2009
  8. pmc Altered regulation of energy homeostasis in older rats in response to thyroid hormone administration
    Stephane Walrand
    1Endocrinology Research Unit, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    FASEB J 28:1499-510. 2014
  9. pmc Insulin fails to enhance mTOR phosphorylation, mitochondrial protein synthesis, and ATP production in human skeletal muscle without amino acid replacement
    Rocco Barazzoni
    Endocrine Research Unit, Mayo Clinic, Rochester, MN, USA
    Am J Physiol Endocrinol Metab 303:E1117-25. 2012
  10. pmc Can dietary nitrates enhance the efficiency of mitochondria?
    K Sreekumaran Nair
    Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Cell Metab 13:117-8. 2011

Detail Information

Publications70

  1. ncbi request reprint Aging muscle
    K Sreekumaran Nair
    Mayo Clinic College of Medicine, Division of Endocrinology and Endocrine Research, Rochester, MN 55905, USA
    Am J Clin Nutr 81:953-63. 2005
    ..Voluntary physical activity is regulated by cognitive centers and could attenuate the progressive decline in mitochondrial functions that occurs with age...
  2. pmc Age, obesity, and sex effects on insulin sensitivity and skeletal muscle mitochondrial function
    Helen Karakelides
    Division of Endocrinology, Endocrinology Research Unit, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Diabetes 59:89-97. 2010
    ..The objective was to determine whether insulin resistance and mitochondrial dysfunction are directly related to chronological age or are related to age-related changes in body composition...
  3. pmc The effect of high glucocorticoid administration and food restriction on rodent skeletal muscle mitochondrial function and protein metabolism
    Y Nancy You
    Endocrine Research Unit, Mayo Clinic College of Medicine, Rochester, MN, USA
    PLoS ONE 4:e5283. 2009
    ....
  4. pmc Quantitative metabolomics by H-NMR and LC-MS/MS confirms altered metabolic pathways in diabetes
    Ian R Lanza
    Endocrinology Research Unit, Division of Endocrinology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
    PLoS ONE 5:e10538. 2010
    ....
  5. pmc Identification of de novo synthesized and relatively older proteins: accelerated oxidative damage to de novo synthesized apolipoprotein A-1 in type 1 diabetes
    Abdul Jaleel
    Division of Endocrinology, Mayo Clinic, Rochester, Minnesota, USA
    Diabetes 59:2366-74. 2010
    ....
  6. pmc Function-based discovery of significant transcriptional temporal patterns in insulin stimulated muscle cells
    Barbara Di Camillo
    Information Engineering Department, University of Padova, Padova, Italy
    PLoS ONE 7:e32391. 2012
    ....
  7. pmc Effect of testosterone on insulin stimulated IRS1 Ser phosphorylation in primary rat myotubes--a potential model for PCOS-related insulin resistance
    Michael C Allemand
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Mayo Clinic Graduate School of Medicine, Rochester, Minnesota, United States of America
    PLoS ONE 4:e4274. 2009
    ..The phosphorylation of Akt, mTOR, and S6K, downstream targets of the PI3-kinase-IRS-1 complex were also studied...
  8. pmc Altered regulation of energy homeostasis in older rats in response to thyroid hormone administration
    Stephane Walrand
    1Endocrinology Research Unit, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    FASEB J 28:1499-510. 2014
    ..Walrand, S., Short, K. R., Heemstra, L. A., Novak, C. M., Levine, J. A., Coenen-Schimke, J. M., Nair, K. S. Altered regulation of energy homeostasis in older rats in response to thyroid hormone administration. ..
  9. pmc Insulin fails to enhance mTOR phosphorylation, mitochondrial protein synthesis, and ATP production in human skeletal muscle without amino acid replacement
    Rocco Barazzoni
    Endocrine Research Unit, Mayo Clinic, Rochester, MN, USA
    Am J Physiol Endocrinol Metab 303:E1117-25. 2012
    ..These results support that insulin and AA act in conjunction to stimulate muscle mitochondrial function and mitochondrial protein synthesis...
  10. pmc Can dietary nitrates enhance the efficiency of mitochondria?
    K Sreekumaran Nair
    Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Cell Metab 13:117-8. 2011
    ..It is an attractive hypothesis that dietary changes enhance energy efficiency, but its potential application depends on long-term studies investigating net benefits versus adverse effects...
  11. pmc Coingestion of whey protein and casein in a mixed meal: demonstration of a more sustained anabolic effect of casein
    Mattias Soop
    Division of Endocrinology, Mayo Clinic, Rochester, MN 55905, USA
    Am J Physiol Endocrinol Metab 303:E152-62. 2012
    ..Early after meal ingestion, amino acid absorption and retention across the leg were similar for WP and Cas, but as rates for WP waned, absorption and assimilation into skeletal muscle were better retained for Cas...
  12. pmc Concordance of changes in metabolic pathways based on plasma metabolomics and skeletal muscle transcriptomics in type 1 diabetes
    Tumpa Dutta
    Division of Endocrinology and Endocrine Research Unit Rochester, Rochester, Minnesota, USA
    Diabetes 61:1004-16. 2012
    ..Future research needs to be focused on newly discovered pathways affected by insulin deficiency and systemic insulin treatment to determine whether they contribute to the high morbidity and mortality in T1D despite insulin treatment...
  13. pmc Mitochondrial function as a determinant of life span
    Ian R Lanza
    Division of Endocrinology, Endocrinology Research Unit, Mayo Clinic College of Medicine, Rochester, MN, USA
    Pflugers Arch 459:277-89. 2010
    ..Regular aerobic exercise and prevention of adiposity by healthy diet may increase healthy life expectancy and prolong life span through beneficial effects at the level of the mitochondrion...
  14. ncbi request reprint Hormonal and signaling role of branched-chain amino acids
    K Sreekumaran Nair
    Mayo Clinic College of Medicine, Rochester, MN, USA
    J Nutr 135:1547S-52S. 2005
    ..It also remains to be determined whether potential adverse effects of BCAA supplementation is similar in people of different age groups...
  15. ncbi request reprint Asian Indians have enhanced skeletal muscle mitochondrial capacity to produce ATP in association with severe insulin resistance
    K Sreekumaran Nair
    Division of Endocrinology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Diabetes 57:1166-75. 2008
    ..We investigated whether Indians had any metabolic differences compared with Northern European Americans that may render them more susceptible to diabetes...
  16. ncbi request reprint DHEA in elderly women and DHEA or testosterone in elderly men
    K Sreekumaran Nair
    Division of Endocrinology, Mayo Clinic, Rochester, MN 55905, USA
    N Engl J Med 355:1647-59. 2006
    ..Dehydroepiandrosterone (DHEA) and testosterone are widely promoted as antiaging supplements, but the long-term benefits, as compared with potential harm, are unknown...
  17. ncbi request reprint Amino acid and protein metabolism in chronic renal failure
    K Sreekumaran Nair
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Ren Nutr 15:28-33. 2005
    ..In this review, the importance of this metabolic role of the kidney is discussed in context of chronic renal failure. The effect of renal failure on skeletal muscle protein metabolism is also discussed...
  18. pmc The effect of branched chain amino acids on skeletal muscle mitochondrial function in young and elderly adults
    Laura L Tatpati
    Mayo Clinic, 200 First Street SW, Joseph 5 194, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 95:894-902. 2010
    ..Branched chain amino acids (BCAA) have been extensively used to improve physical performance...
  19. ncbi request reprint Muscle changes in aging
    R Basu
    K Sreekumaran Nair, MD, PhD, Mayo Clinic Foundation200 1st Street SW, Rm 5 194, Rochester, MN 55905, U S A Phone 507 255 6515 Fax 507 255 4828 E mail
    J Nutr Health Aging 6:336-41. 2002
    ..An individualized exercise prescription involving both aerobic and resistance training is definitely helpful to overcome many aging-related muscle dysfunctions...
  20. ncbi request reprint Skeletal muscle mitochondrial dysfunction & diabetes
    Raghavakaimal Sreekumar
    Endocrinology Division, Mayo Clinic, Rochester, MN 55905, USA
    Indian J Med Res 125:399-410. 2007
    ..The lack of muscle mitochondrial response to insulin in type 2 diabetic patients is likely to be related to insulin resistance and reduced substrate utilization...
  21. ncbi request reprint Proteomic research: potential opportunities for clinical and physiological investigators
    K Sreekumaran Nair
    Mayo Clinic School of Medicine, Endocrinology Research Unit, Joseph 5 194, 200 First St SW, Rochester, MN 55905, USA
    Am J Physiol Endocrinol Metab 286:E863-74. 2004
    ..Such mechanistic information will improve the ability to perform early diagnosis of tumors and other diseases and develop prognostic indexes and novel therapies...
  22. ncbi request reprint Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacity
    Kevin R Short
    Department of Internal Medicine, Division of Endocrinology, Mayo Clinic, Rochester, Minnesota, USA
    Diabetes 52:1888-96. 2003
    ..Thus, the muscle mitochondrial response to 4 months of aerobic exercise training was similar in all age-groups, although the older people did not have an improvement in insulin sensitivity...
  23. pmc Functional impact of high protein intake on healthy elderly people
    Stephane Walrand
    Endocrinology Research Unit, Mayo Clinic School of Medicine, Rochester, Minnesota 55905, USA
    Am J Physiol Endocrinol Metab 295:E921-8. 2008
    ..Additionally, widening differences in GFR between young and older patients is a potential cause of concern in using HP diet in older people...
  24. pmc Dehydroepiandrosterone replacement therapy in hypoadrenal women: protein anabolism and skeletal muscle function
    Ketan K Dhatariya
    Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 83:1218-25. 2008
    ..To determine whether dehydroepiandrosterone (DHEA) replacement therapy in hypoadrenal women improves performance, muscle protein accretion, and mitochondrial functions...
  25. pmc Lack of dehydroepiandrosterone effect on a combined endurance and resistance exercise program in postmenopausal women
    Ada Igwebuike
    Division of Endocrinology, Endocrine Research Unit, Mayo Clinic, 200 First Street SW, Joseph 5 194, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 93:534-8. 2008
    ....
  26. ncbi request reprint Synthesis rate of muscle proteins, muscle functions, and amino acid kinetics in type 2 diabetes
    Panagiotis Halvatsiotis
    Division of Endocrinology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Diabetes 51:2395-404. 2002
    ..Insulin treatments in subjects with type 2 diabetes had no effect on muscle mitochondrial protein synthesis and cytochrome C oxidase, a key enzyme for ATP production...
  27. ncbi request reprint Effect of insulin deprivation on muscle mitochondrial ATP production and gene transcript levels in type 1 diabetic subjects
    Helen Karakelides
    Division of Endocrinology and Metabolism and Endocrine Research Unit, Mayo Clinic, 200 First St SW, Joseph 5 194, Rochester, MN 55905, USA
    Diabetes 56:2683-9. 2007
    ..We determined the impact of insulin deficiency on muscle mitochondrial ATP production by temporarily depriving type 1 diabetic patients of insulin treatment...
  28. ncbi request reprint Skeletal muscle mitochondrial functions, mitochondrial DNA copy numbers, and gene transcript profiles in type 2 diabetic and nondiabetic subjects at equal levels of low or high insulin and euglycemia
    Yan W Asmann
    Endocrinology Research Unit, Mayo Clinic, 200 First St SW, Joseph 5 194, Rochester, MN 55905, USA
    Diabetes 55:3309-19. 2006
    ..In conclusion, the current data supports that muscle mitochondrial dysfunction in type 2 diabetes is not an intrinsic defect, but instead a functional defect related to impaired response to insulin...
  29. ncbi request reprint Changes in skeletal muscle protein metabolism and myosin heavy chain isoform messenger ribonucleic acid abundance after treatment of hyperthyroidism
    Michael D Brennan
    Division of Endocrinology, Metabolism and Nutrition, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 91:4650-6. 2006
    ..Hyperthyroidism causes a hypermetabolic state and skeletal muscle dysfunction, but the underlying mechanism remains incompletely defined...
  30. pmc Endurance exercise as a countermeasure for aging
    Ian R Lanza
    Division of Endocrinology, Endocrinology Research Unit, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Diabetes 57:2933-42. 2008
    ..We determined whether reduced insulin sensitivity, mitochondrial dysfunction, and other age-related dysfunctions are inevitable consequences of aging or secondary to physical inactivity...
  31. ncbi request reprint Differential regulation of protein dynamics in splanchnic and skeletal muscle beds by insulin and amino acids in healthy human subjects
    Jonas Nygren
    Division of Endocrinology, Mayo Clinic and Foundation, Joseph 5 194, 200 First Street SW, Rochester, MN 55905, USA
    Diabetes 52:1377-85. 2003
    ..AAs largely determined protein anabolism in splanchnic bed by stimulating PS and decreasing protein breakdown...
  32. ncbi request reprint Age and aerobic exercise training effects on whole body and muscle protein metabolism
    Kevin R Short
    Endocrinology Research Unit, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Am J Physiol Endocrinol Metab 286:E92-101. 2004
    ..This study also demonstrates that aerobic exercise can enhance muscle protein synthesis irrespective of age...
  33. pmc Short-term prednisone use antagonizes insulin's anabolic effect on muscle protein and glucose metabolism in young healthy people
    Kevin R Short
    Endocrinology Research Unit, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Am J Physiol Endocrinol Metab 297:E1260-8. 2009
    ..This interactive effect may lead to muscle atrophy with continued use of glucocorticoids...
  34. pmc Differential effects of insulin deprivation and systemic insulin treatment on plasma protein synthesis in type 1 diabetic people
    Abdul Jaleel
    Division of Endocrinology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Physiol Endocrinol Metab 297:E889-97. 2009
    ..Moreover, chronic systemic insulin treatment not only did not normalize synthesis of all plasma proteins but also altered synthesis of several additional proteins that were unaltered during insulin deprivation...
  35. ncbi request reprint Aging and diabetes: mitochondrial dysfunction
    Brian A Irving
    Division of Endocrinology, Endocrine Research Unit, Mayo Clinic College of Medicine, 200 First Street SW, Joseph 5 194, Rochester, MN 55905, USA
    Curr Diab Rep 7:249-51. 2007
  36. pmc In vivo measurement of synthesis rate of individual skeletal muscle mitochondrial proteins
    Abdul Jaleel
    Division of Endocrinology, Endocrine Research Unit, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Am J Physiol Endocrinol Metab 295:E1255-68. 2008
    ..5 +/- 0.42%/h). This method offers an opportunity to better define the translational regulation of proteins in skeletal muscle or other tissues...
  37. ncbi request reprint Effect of 2 years of testosterone replacement on insulin secretion, insulin action, glucose effectiveness, hepatic insulin clearance, and postprandial glucose turnover in elderly men
    Rita Basu
    Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Diabetes Care 30:1972-8. 2007
    ..We sought to determine whether, and if so the mechanism by which, testosterone replacement improves carbohydrate tolerance...
  38. ncbi request reprint Effect of dehydroepiandrosterone replacement on insulin sensitivity and lipids in hypoadrenal women
    Ketan Dhatariya
    Endocrine Research Unit, Joseph 5 194, Mayo Clinic and Foundation, 200 First St, SW, Rochester, MN 55905, USA
    Diabetes 54:765-9. 2005
    ..In conclusion, replacement therapy with 50 mg of DHEA for 12 weeks significantly increased insulin sensitivity in hypoadrenal women, thereby suggesting that DHEA replacement could have a potential impact in preventing type 2 diabetes...
  39. ncbi request reprint Effects of free fatty acids and glycerol on splanchnic glucose metabolism and insulin extraction in nondiabetic humans
    Pankaj Shah
    Endocrine Research Unit, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Diabetes 51:301-10. 2002
    ..They increase the contribution of the indirect pathway to glycogen synthesis and impair hepatic autoregulation. On the other hand, they do not alter either splanchnic glucose uptake or splanchnic insulin extraction in nondiabetic humans...
  40. pmc Muscle mitochondrial changes with aging and exercise
    Ian R Lanza
    Division of Endocrinology, Endocrinology Research Unit, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Am J Clin Nutr 89:467S-71S. 2009
    ....
  41. ncbi request reprint Mechanism of insulin's anabolic effect on muscle: measurements of muscle protein synthesis and breakdown using aminoacyl-tRNA and other surrogate measures
    Lisa S Chow
    Division of Endocrinology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Am J Physiol Endocrinol Metab 291:E729-36. 2006
    ....
  42. pmc Decline in skeletal muscle mitochondrial function with aging in humans
    Kevin R Short
    Endocrine Research Unit and Department of Laboratory Medicine, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Proc Natl Acad Sci U S A 102:5618-23. 2005
    ..These results demonstrate that age-related muscle mitochondrial dysfunction is related to reduced mtDNA and muscle functional changes that are common in the elderly...
  43. ncbi request reprint Gene expression profile in skeletal muscle of type 2 diabetes and the effect of insulin treatment
    Raghavakaimal Sreekumar
    Endocrinology Division, Mayo Clinic, Rochester, Minnesota 55905, USA
    Diabetes 51:1913-20. 2002
    ..This study identified several candidate genes for muscle insulin resistance, complications associated with poor glycemic control, and effects of insulin treatment in people with type 2 diabetes...
  44. pmc Fatty acid metabolism in the elderly: effects of dehydroepiandrosterone and testosterone replacement in hormonally deficient men and women
    Christina Koutsari
    Endocrine Research, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 94:3414-23. 2009
    ..Aging, low dehydroepiandrosterone (DHEA), and testosterone are associated with increased adiposity and metabolic risk. Treatment with these hormones may improve these abnormalities...
  45. ncbi request reprint Effect of short-term prednisone use on blood flow, muscle protein metabolism, and function
    Kevin R Short
    Endocrinology Research Unit, Mayo Clinic School of Medicine, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 89:6198-207. 2004
    ..These results demonstrate that a short-term moderate dose of prednisone affects glucose metabolism but has no effect on whole-body or leg muscle protein metabolism or muscle function...
  46. pmc Protein and energy metabolism in type 1 diabetes
    Sadie L Hebert
    Mayo Clinic, 200 First St SW, Joseph 5 194, Rochester, MN 55905, USA
    Clin Nutr 29:13-7. 2010
    ..During insulin deprivation the splanchnic bed has a net protein accretion which accounts for the total increase in whole-body protein synthesis while muscle is in a net catabolic state...
  47. pmc Impact of type 1 diabetes and insulin treatment on plasma levels and fractional synthesis rate of retinol-binding protein 4
    Marion Jourdan
    Division of Endocrinology and Metabolism, Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 94:5125-30. 2009
    ..In vivo synthesis rates of RBP4 and their relationship to RBP4 levels remain to be determined...
  48. pmc Effects of adiposity and 30 days of caloric restriction upon protein metabolism in moderately vs. severely obese women
    Gregory C Henderson
    Division of Endocrinology, Mayo Clinic, Rochester, Minnesota, USA
    Obesity (Silver Spring) 18:1135-42. 2010
    ..We conclude that fat mass, like FFM, is a key determinant of protein turnover. However, during CR, higher fat mass does not favorably alter the response of protein metabolism and does not mitigate the loss of FFM...
  49. pmc Effect of insulin on human skeletal muscle mitochondrial ATP production, protein synthesis, and mRNA transcripts
    Craig S Stump
    Department of Endocrinology, Metabolism, and Nutrition, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Proc Natl Acad Sci U S A 100:7996-8001. 2003
    ..Skeletal muscle of type 2 diabetic patients has a reduced capacity to increase ATP production with high insulin levels...
  50. ncbi request reprint Effect of hyperthyroidism on spontaneous physical activity and energy expenditure in rats
    James A Levine
    Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Appl Physiol (1985) 94:165-70. 2003
    ..8 to 19.7 +/- 5.0 kcal/day (P < 0.001) but did not increase in the controls (8.7 +/- 3.5 cf 9.4 +/- 1.7 kcal/day; not significant). In conclusion, hyperthyroidism is associated with increased spontaneous physical activity and NEAT...
  51. ncbi request reprint Effects of caloric restriction on mitochondrial function and gene transcripts in rat muscle
    R Sreekumar
    Endocrinology Division, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Physiol Endocrinol Metab 283:E38-43. 2002
    ..Alterations in transcripts of many genes involved in reactive oxygen scavenging function may contribute to the increase in longevity reported with CR...
  52. ncbi request reprint Impact of high-fat diet and antioxidant supplement on mitochondrial functions and gene transcripts in rat muscle
    R Sreekumar
    Endocrinology Division, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Physiol Endocrinol Metab 282:E1055-61. 2002
    ..Antioxidants partially prevent these changes. Mitochondrial functions in skeletal muscle remain unaltered by the dietary intervention due to many adaptive changes in gene transcription...
  53. ncbi request reprint Apolipoprotein synthesis in nonalcoholic steatohepatitis
    Michael Charlton
    Department of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Hepatology 35:898-904. 2002
    ..In conclusion, because apoB-100 synthesis is a rate-determining step in hepatocyte lipid export, decreased synthesis of this protein may be an important factor in the development of hepatic steatosis, a prerequisite for NASH...
  54. ncbi request reprint Identification of Amadori-modified plasma proteins in type 2 diabetes and the effect of short-term intensive insulin treatment
    Abdul Jaleel
    Endocrinology Unit, Mayo Clinic, 200 First St, SW, 5 194 Joseph, Rochester, MN 55905, USA
    Diabetes Care 28:645-52. 2005
    ....
  55. ncbi request reprint Changes in myosin heavy chain mRNA and protein expression in human skeletal muscle with age and endurance exercise training
    Kevin R Short
    Division of Endocrinology, Department of Internal Medicine, Mayo Clinic School of Medicine, 200 First St SW, Rochester, MN 55905, USA
    J Appl Physiol 99:95-102. 2005
    ..In response to endurance exercise, regulation of MHC isoform transcripts remains robust in older muscle, but this did not result in corresponding changes in MHC protein expression...
  56. pmc Enhancement of muscle mitochondrial function by growth hormone
    Kevin R Short
    Endocrinology Research Unit, Mayo Clinic School of Medicine, 5 194 Joseph, 200 First Street SW, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 93:597-604. 2008
    ..Although GH promotes growth and protein anabolism, which are ATP-dependent processes, the GH effect on mitochondrial regulation remains to be determined...
  57. ncbi request reprint Impact of endurance training on murine spontaneous activity, muscle mitochondrial DNA abundance, gene transcripts, and function
    Lisa S Chow
    Division of Endocrinology, Nutrition and Metabolism, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Appl Physiol 102:1078-89. 2007
    ....
  58. ncbi request reprint Effect of T(3)-induced hyperthyroidism on mitochondrial and cytoplasmic protein synthesis rates in oxidative and glycolytic tissues in rats
    Kevin R Short
    Endocrine Research Unit, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Am J Physiol Endocrinol Metab 292:E642-7. 2007
    ....
  59. ncbi request reprint The impact of overt and subclinical hyperthyroidism on skeletal muscle
    Michael D Brennan
    Division of Endocrinology, Diabetes, Nutrition and Metabolism, Mayo Clinic, Rochester, Minnesota 55905, USA
    Thyroid 16:375-80. 2006
    ..This may have clinical relevance as SCH patients are often elderly and may therefore have concurrent sarcopenia of aging and would represent a previously unrecognized complication of SCH...
  60. pmc Higher muscle protein synthesis in women than men across the lifespan, and failure of androgen administration to amend age-related decrements
    Gregory C Henderson
    Division of Endocrinology, Mayo Clinic, Rochester, MN 55905, USA
    FASEB J 23:631-41. 2009
    ....
  61. pmc Frailty and its potential relevance to cardiovascular care
    Mandeep Singh
    Division of Cardiovascular Diseases, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Mayo Clin Proc 83:1146-53. 2008
    ..We also elaborate on reasons to consider frailty in older adults with cardiovascular disease and focus on its early identification, on referral to specialists, and on care after serious cardiac events...
  62. ncbi request reprint Assessment of branched-chain amino Acid status and potential for biomarkers
    Andrea Tom
    Endocrinology Research Unit, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    J Nutr 136:324S-30S. 2006
    ..We also discuss potential biomarkers of BCAA status...
  63. ncbi request reprint Anthropometric prediction of total body water in children who are on pediatric peritoneal dialysis
    Bruce Z Morgenstern
    Division of Pediatric Nephrology, Phoenix Children s Hospital, 1919 East Thomas Road, Phoenix, AZ 85016, USA
    J Am Soc Nephrol 17:285-93. 2006
    ..In summary, a new set of anthropometric TBW prediction equations that are suited specifically for use in pediatric PD patients have been provided...
  64. ncbi request reprint Impairment of phenylalanine conversion to tyrosine in end-stage renal disease causing tyrosine deficiency
    Yves Boirie
    Endocrine Research Unit, Division of Endocrinology and Metabolism, and Nephrology Department, Mayo Clinicand Foundation, Rochester, Minnesota 55905, USA
    Kidney Int 66:591-6. 2004
    ..Tyrosine is not considered an indispensable amino acid because in humans phenylalanine is converted to tyrosine. Recent human studies demonstrated that tyrosine production from phenylalanine occurs not only in liver but also in kidney...
  65. ncbi request reprint Effects of insulin deprivation and treatment on homocysteine metabolism in people with type 1 diabetes
    Haitham S Abu-Lebdeh
    Endocrine Research Unit, Mayo Clinic, 200 First Street SW, Joseph 5 194, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 91:3344-8. 2006
    ..Amino acid metabolism is altered in T1DM. In vitro, insulin reduces hepatic catabolism of homocysteine by inhibiting liver transsulfuration. It remains to be determined whether methionine-homocysteine metabolism is altered in T1DM...
  66. ncbi request reprint Changes in body composition in women following treatment of overt and subclinical hyperthyroidism
    Laura J S Greenlund
    Division of Endocrinology, Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    Endocr Pract 14:973-8. 2008
    ..To determine changes in weight, body composition, and bone density after treatment of overt hyperthyroidism (OH) and subclinical hyperthyroidism (SCH) in women...
  67. ncbi request reprint Elevated free fatty acids impair glucose metabolism in women: decreased stimulation of muscle glucose uptake and suppression of splanchnic glucose production during combined hyperinsulinemia and hyperglycemia
    Pankaj Shah
    Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
    Diabetes 52:38-42. 2003
    ....
  68. pmc Functional assessment of isolated mitochondria in vitro
    Ian R Lanza
    Division of Endocrinology, Endocrinology Research Unit, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Methods Enzymol 457:349-72. 2009
    ....
  69. pmc Effects on lipoprotein particles of long-term dehydroepiandrosterone in elderly men and women and testosterone in elderly men
    Manivannan Srinivasan
    Division of Endocrinology, Endocrine Research Unit, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 95:1617-25. 2010
    ..Although age-related declines in dehydroepiandrosterone sulfate (DHEAS) and testosterone are associated with cardiovascular risk, it remains to be determined whether replacement of these hormones improves cardiovascular risk factors...
  70. ncbi request reprint Dehydroepiandrosterone in adrenal insufficiency and ageing
    Sumit Bhagra
    Division of Endocrinology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Curr Opin Endocrinol Diabetes Obes 15:239-43. 2008
    ..The objective of this study is to critically review published results and determine whether there is a valid case for dehydroepiandrosterone treatment with advancing age and hypoadrenalism...

Research Grants34

  1. PATHOGENESIS OF SARCOPENIA AND METABOLIC CHANGE IN AGING
    K Nair; Fiscal Year: 2004
    ..This study will hopefully form the scientific basis for future trials of androgen replacement in the elderly. ..
  2. IN VIVO REGULATION OF PROTEIN TURNOVER BY HORMONES
    K Nair; Fiscal Year: 2005
    ..In addition, the studies will hopefully provide novel insights on pathophysiology muscle insulin resistance and mito functions in T2D patients. ..
  3. MECHANISM OF MUSCLE WASTING IN AGING MAN
    K Nair; Fiscal Year: 2006
    ..abstract_text> ..
  4. Plasma protein synthesis and abundance in T1 diabetes
    K Nair; Fiscal Year: 2007
    ..These studies are anticipated to form the basis of more elaborate mechanistic studies in the future and hopefully will lead to alternative therapeutic approaches for T1 D. ..
  5. IN VIVO REGULATION OF PROTEIN TURNOVER BY HORMONES
    K Nair; Fiscal Year: 2006
    ..In addition, the studies will hopefully provide novel insights on pathophysiology muscle insulin resistance and mito functions in T2D patients. ..
  6. MECHANISM OF MUSCLE WASTING IN AGING MAN
    K Nair; Fiscal Year: 2007
    ..abstract_text> ..
  7. IN VIVO REGULATION OF PROTEIN TURNOVER BY HORMONES
    K Nair; Fiscal Year: 2007
    ..In addition, the studies will hopefully provide novel insights on pathophysiology muscle insulin resistance and mito functions in T2D patients. ..
  8. MECHANISM OF MUSCLE WASTING IN AGING MAN
    K Sreekumaran Nair; Fiscal Year: 2009
    ..abstract_text> ..
  9. IN VIVO REGULATION OF PROTEIN TURNOVER BY HORMONES
    K Sreekumaran Nair; Fiscal Year: 2009
    ..In addition, the studies will hopefully provide novel insights on pathophysiology muscle insulin resistance and mito functions in T2D patients. ..
  10. IN VIVO REGULATION OF PROTEIN TURNOVER BY HORMONES
    K Sreekumaran Nair; Fiscal Year: 2010
    ....
  11. IN VIVO REGULATION OF PROTEIN TURNOVER BY HORMONES
    K Sreekumaran Nair; Fiscal Year: 2010
    ..In addition, the studies will hopefully provide novel insights on pathophysiology muscle insulin resistance and mito functions in T2D patients. ..
  12. MECHANISM OF MUSCLE WASTING IN AGING MAN
    K Nair; Fiscal Year: 2005
    ..abstract_text> ..
  13. IN VIVO REGULATION OF PROTEIN TURNOVER BY HORMONES
    K Sreekumaran Nair; Fiscal Year: 2004
    ..These results will allow us to better understand the pathophysiology of this disorder and its chronic complications. ..
  14. MECHANISM OF MUSCLE WASTING IN AGING MAN
    K Nair; Fiscal Year: 1999
    ..abstract_text> ..
  15. MECHANISM OF MUSCLE WASTING IN AGING MAN
    K Nair; Fiscal Year: 2000
    ..abstract_text> ..
  16. IN VIVO REGULATION OF PROTEIN TURNOVER BY HORMONES
    K Nair; Fiscal Year: 2000
    ..These results will allow us to better understand the pathophysiology of this disorder and its chronic complications. ..
  17. MECHANISM OF MUSCLE WASTING IN AGING MAN
    K Nair; Fiscal Year: 2001
    ..abstract_text> ..
  18. IN VIVO REGULATION OF PROTEIN TURNOVER BY HORMONES
    K Nair; Fiscal Year: 2001
    ..These results will allow us to better understand the pathophysiology of this disorder and its chronic complications. ..
  19. MECHANISM OF MUSCLE WASTING IN AGING MAN
    K Nair; Fiscal Year: 2002
    ..abstract_text> ..
  20. IN VIVO REGULATION OF PROTEIN TURNOVER BY HORMONES
    K Nair; Fiscal Year: 2002
    ..These results will allow us to better understand the pathophysiology of this disorder and its chronic complications. ..
  21. MECHANISM OF MUSCLE WASTING IN AGING MAN
    K Sreekumaran Nair; Fiscal Year: 2003
    ..abstract_text> ..
  22. IN VIVO REGULATION OF PROTEIN TURNOVER BY HORMONES
    K Nair; Fiscal Year: 2003
    ..These results will allow us to better understand the pathophysiology of this disorder and its chronic complications. ..
  23. MECHANISM OF MUSCLE WASTING IN AGING MAN
    K Sreekumaran Nair; Fiscal Year: 2010
    ..Understanding the cause of muscle weakness could pave the way for preventive and therapeutic strategies to help maintain or improve quality of life with advanced age. ..