Debabrata Mukhopadhyay

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. ncbi Antiangiogenic properties of gold nanoparticles
    Priyabrata Mukherjee
    Department of Biochemistry, Mayo Clinic Cancer Center, Rochester, Minnesota 55905, USA
    Clin Cancer Res 11:3530-4. 2005
  2. ncbi Complexity in the vascular permeability factor/vascular endothelial growth factor (VPF/VEGF)-receptors signaling
    Debabrata Mukhopadhyay
    Mayo Clinic Cancer Center, Department of Biochemistry and Molecular Biology, Mayo Clinic Foundation, Gugg, Rochester, MN 55905, USA
    Mol Cell Biochem 264:51-61. 2004
  3. ncbi Src homology 2 (SH2) domain containing protein tyrosine phosphatase-1 (SHP-1) dephosphorylates VEGF Receptor-2 and attenuates endothelial DNA synthesis, but not migration*
    Resham Bhattacharya
    Department of Biochemistry and Molecular Biology and Mayo Clinic Cancer Center, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Mol Signal 3:8. 2008
  4. ncbi The tumor suppressor von Hippel-Lindau gene product and metastasis: new thoughts on an old molecule
    Debabrata Mukhopadhyay
    Department of Biochemistry and Molecular Biology, Mayo Clinic Cancer Center, Mayo Clinic Foundation, Rochester, MN 55905, USA
    Am J Pathol 168:367-9. 2006
  5. ncbi The neurotransmitter dopamine modulates vascular permeability in the endothelium
    Resham Bhattacharya
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN, USA
    J Mol Signal 3:14. 2008
  6. ncbi Wall shear stress measurement using phase contrast magnetic resonance imaging with phase contrast magnetic resonance angiography in arteriovenous polytetrafluoroethylene grafts
    Sanjay Misra
    Department of Radiology, Division of Vascular and Interventional Radiology, Mayo Clinic College of Medicine, 200 First Street SW, Alfred 6460, Rochester, MN 55902, USA
    Angiology 60:441-7. 2009
  7. ncbi Dopamine regulates phosphorylation of VEGF receptor 2 by engaging Src-homology-2-domain-containing protein tyrosine phosphatase 2
    Sutapa Sinha
    Department of Biochemistry and Molecular Biology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Cell Sci 122:3385-92. 2009
  8. ncbi Adventitial transplantation of blood outgrowth endothelial cells in porcine haemodialysis grafts alleviates hypoxia and decreases neointimal proliferation through a matrix metalloproteinase-9-mediated pathway--a pilot study
    Deborah Hughes
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Nephrol Dial Transplant 24:85-96. 2009
  9. ncbi Insulin receptor substrate-2 mediated insulin-like growth factor-I receptor overexpression in pancreatic adenocarcinoma through protein kinase Cdelta
    Junhye Kwon
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Cancer Res 69:1350-7. 2009
  10. ncbi Distinct role of PLCbeta3 in VEGF-mediated directional migration and vascular sprouting
    Resham Bhattacharya
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Cell Sci 122:1025-34. 2009

Research Grants

  1. Distinct Pathways of VPF/VEGF Receptors
    Debabrata Mukhopadhyay; Fiscal Year: 2005
  2. REGULATORY PATHWAYS AND ROLE OF VPF/VEGF IN RENAL CANCER
    Debabrata Mukhopadhyay; Fiscal Year: 2009
  3. Distinct Pathways of VPF/VEGF Receptors
    Debabrata Mukhopadhyay; Fiscal Year: 2007
  4. REGULATORY PATHWAYS AND ROLE OF VPF/VEGF IN RENAL CANCER
    Debabrata Mukhopadhyay; Fiscal Year: 2007
  5. Distinct Pathways of VPF/VEGF Receptors
    Debabrata Mukhopadhyay; Fiscal Year: 2010
  6. Targeting Pancreatic Cancer Using Peptide Chemistry: From Bench to Bedside
    Mark R Spaller; Fiscal Year: 2010
  7. The Neurotransmitter dopamine and angiogenesis
    Debabrata Mukhopadhyay; Fiscal Year: 2007
  8. Neurotransmitter dopamine and angiogenesis
    Debabrata Mukhopadhyay; Fiscal Year: 2003
  9. The Neurotransmitter dopamine and angiogenesis
    Debabrata Mukhopadhyay; Fiscal Year: 2006
  10. REGULATORY PATHWAYS AND ROLE OF VPF/VEGF IN RENAL CANCER
    Debabrata Mukhopadhyay; Fiscal Year: 2010

Detail Information

Publications90

  1. ncbi Antiangiogenic properties of gold nanoparticles
    Priyabrata Mukherjee
    Department of Biochemistry, Mayo Clinic Cancer Center, Rochester, Minnesota 55905, USA
    Clin Cancer Res 11:3530-4. 2005
    ..These results report for the first time a novel property of gold nanoparticles to bind heparin-binding proteins and thereby inhibit their subsequent signaling events...
  2. ncbi Complexity in the vascular permeability factor/vascular endothelial growth factor (VPF/VEGF)-receptors signaling
    Debabrata Mukhopadhyay
    Mayo Clinic Cancer Center, Department of Biochemistry and Molecular Biology, Mayo Clinic Foundation, Gugg, Rochester, MN 55905, USA
    Mol Cell Biochem 264:51-61. 2004
    ..To this end, we conclude that more research needs to be done for completely understanding the VPF/VEGF biology with relation to angiogenesis...
  3. ncbi Src homology 2 (SH2) domain containing protein tyrosine phosphatase-1 (SHP-1) dephosphorylates VEGF Receptor-2 and attenuates endothelial DNA synthesis, but not migration*
    Resham Bhattacharya
    Department of Biochemistry and Molecular Biology and Mayo Clinic Cancer Center, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Mol Signal 3:8. 2008
    ..However, the mechanism by which SHP-1 executes KDR dephosphorylation, the targeted tyrosine residue(s) of KDR and also overall downstream signaling or phenotypic change(s) caused, is not defined...
  4. ncbi The tumor suppressor von Hippel-Lindau gene product and metastasis: new thoughts on an old molecule
    Debabrata Mukhopadhyay
    Department of Biochemistry and Molecular Biology, Mayo Clinic Cancer Center, Mayo Clinic Foundation, Rochester, MN 55905, USA
    Am J Pathol 168:367-9. 2006
  5. ncbi The neurotransmitter dopamine modulates vascular permeability in the endothelium
    Resham Bhattacharya
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN, USA
    J Mol Signal 3:14. 2008
    ..It is known that the neurotransmitter dopamine can inhibit VPF/VEGF mediated angiogenesis, in particular microvascular permeability, but the effectors of this action remain unclear...
  6. ncbi Wall shear stress measurement using phase contrast magnetic resonance imaging with phase contrast magnetic resonance angiography in arteriovenous polytetrafluoroethylene grafts
    Sanjay Misra
    Department of Radiology, Division of Vascular and Interventional Radiology, Mayo Clinic College of Medicine, 200 First Street SW, Alfred 6460, Rochester, MN 55902, USA
    Angiology 60:441-7. 2009
    ..The purpose of the present article was to determine the changes in luminal vessel area, blood flow, and wall shear stress in both the inflow artery and the venous stenosis of arteriovenous polytetrafluoroethylene (PTFE) grafts...
  7. ncbi Dopamine regulates phosphorylation of VEGF receptor 2 by engaging Src-homology-2-domain-containing protein tyrosine phosphatase 2
    Sutapa Sinha
    Department of Biochemistry and Molecular Biology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Cell Sci 122:3385-92. 2009
    ..Our data establish a novel role for SHP-2 phosphatase in the dopamine-mediated regulation of VEGFR-2 phosphorylation...
  8. ncbi Adventitial transplantation of blood outgrowth endothelial cells in porcine haemodialysis grafts alleviates hypoxia and decreases neointimal proliferation through a matrix metalloproteinase-9-mediated pathway--a pilot study
    Deborah Hughes
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Nephrol Dial Transplant 24:85-96. 2009
    ..Because matrix metalloproteinases (MMPs) have been shown to be involved with angiogenesis, the expression of MMPs and their inhibitors was determined...
  9. ncbi Insulin receptor substrate-2 mediated insulin-like growth factor-I receptor overexpression in pancreatic adenocarcinoma through protein kinase Cdelta
    Junhye Kwon
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Cancer Res 69:1350-7. 2009
    ..Overall, these findings suggest a novel regulatory role of IRS-2 on the expression of IGF-IR through PKCdelta and mTOR in pancreatic cancer cells...
  10. ncbi Distinct role of PLCbeta3 in VEGF-mediated directional migration and vascular sprouting
    Resham Bhattacharya
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Cell Sci 122:1025-34. 2009
    ....
  11. ncbi VEGF neutralizing antibody increases the therapeutic efficacy of vinorelbine for renal cell carcinoma
    Sutapa Sinha
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Cell Mol Med 14:647-58. 2010
    ..We observed a significant tumour growth inhibition when using a combinational therapy of anti-VEGF antibody 2C3 and vinorelbine in both A498 and 786-O tumour-bearing mice. The results suggest a breakthrough treatment for advanced RCC...
  12. ncbi Increased expression of hypoxia-inducible factor-1 alpha in venous stenosis of arteriovenous polytetrafluoroethylene grafts in a chronic renal insufficiency porcine model
    Sanjay Misra
    Department of Radiology, Mayo Medical School, Mayo Clinic, Rochester, MN 55905, USA
    J Vasc Interv Radiol 19:260-5. 2008
    ....
  13. ncbi Increased shear stress with upregulation of VEGF-A and its receptors and MMP-2, MMP-9, and TIMP-1 in venous stenosis of hemodialysis grafts
    Sanjay Misra
    Department of Radiology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Am J Physiol Heart Circ Physiol 294:H2219-30. 2008
    ....
  14. ncbi Von Hippel-Lindau gene product modulates TIS11B expression in renal cell carcinoma: impact on vascular endothelial growth factor expression in hypoxia
    Sutapa Sinha
    Department of Biochemistry and Molecular Biology, Mayo Clinic Foundation, Rochester, Minnesota 55905, USA
    J Biol Chem 284:32610-8. 2009
    ....
  15. ncbi Targeting GIPC/synectin in pancreatic cancer inhibits tumor growth
    Michael H Muders
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Clin Cancer Res 15:4095-103. 2009
    ..Furthermore, the effect of targeting GIPC on the IGF-I receptor as one of its associated receptors was tested...
  16. ncbi Fetuin-A expression in early venous stenosis formation in a porcine model of hemodialysis graft failure
    Sanjay Misra
    Department of Radiology, Mayo Clinic College of Medicine, 200 First Street Southwest, Alfred 6460, Rochester, MN 55905, USA
    J Vasc Interv Radiol 19:1477-82. 2008
    ....
  17. ncbi Neuropilin-1 mediates divergent R-Smad signaling and the myofibroblast phenotype
    Ying Cao
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Biol Chem 285:31840-8. 2010
    ..Taken together, our data suggest that NRP-1 functions as a key determinant of the diverse responses downstream of TGF-β1 that are mediated by distinct Smad proteins and promotes myofibroblast phenotype...
  18. ncbi NHERF-2 maintains endothelial homeostasis
    Resham Bhattacharya
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Blood 119:4798-806. 2012
    ..Thus, NHERF-2 is a negative regulator of endothelial proliferation and may have important roles in endothelial homeostasis and vascular modeling...
  19. ncbi Expression of hypoxia inducible factor-1 alpha, macrophage migration inhibition factor, matrix metalloproteinase-2 and -9, and their inhibitors in hemodialysis grafts and arteriovenous fistulas
    Sanjay Misra
    Department of Radiology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
    J Vasc Interv Radiol 19:252-9. 2008
    ..The present study tested the hypothesis that there are differences in the expression patterns of HIF-1 alpha, MIF, MMP-2, MMP-9, and TIMPs in specimens removed from patients with AVFs and PTFE grafts...
  20. ncbi Neuropilin-1 promotes cirrhosis of the rodent and human liver by enhancing PDGF/TGF-beta signaling in hepatic stellate cells
    Sheng Cao
    Gastroenterology Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Invest 120:2379-94. 2010
    ....
  21. ncbi Fabrication and characterization of an inorganic gold and silica nanoparticle mediated drug delivery system for nitric oxide
    Amitava Das
    Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Nanotechnology 21:305102. 2010
    ..This study indicates that gold and silica nanoparticle mediated drug delivery systems for introducing NO could be used as a strategy for the treatment of hepatic fibrosis or chronic liver diseases, by limiting HSC activation...
  22. ncbi Neuropilin-1 upholds dedifferentiation and propagation phenotypes of renal cell carcinoma cells by activating Akt and sonic hedgehog axes
    Ying Cao
    Department of Biochemistry and Molecular Biology, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer Res 68:8667-72. 2008
    ..Inhibition of sonic hedgehog expression can be reversed by DeltaNp63alpha overexpression. Our study reveals that NRP-1 helps maintain an undifferentiated phenotype in cancer cells...
  23. ncbi Proteomic profiling in early venous stenosis formation in a porcine model of hemodialysis graft
    Sanjay Misra
    Department of Radiology and Division of Vascular and Interventional Radiology, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, MN 55905, USA
    J Vasc Interv Radiol 20:241-51. 2009
    ..To use proteomic analysis to identify up- and downregulated proteins in early venous stenosis formation in a porcine model of hemodialysis graft failure...
  24. ncbi Regulatory role of dynamin-2 in VEGFR-2/KDR-mediated endothelial signaling
    Resham Bhattacharya
    Department of Biochemistry and Molecular Biology, Mayo Clinic Cancer Center, Rochester, Minnesota 55905, USA
    FASEB J 19:1692-4. 2005
    ..Taken together, our findings suggest that dynamin-2 regulates KDR expression and function and hence plays an important role in VPF/VEGF mediated angiogenesis...
  25. ncbi VEGF exerts an angiogenesis-independent function in cancer cells to promote their malignant progression
    Ying Cao
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer Res 72:3912-8. 2012
    ..Our findings define a novel function for VEGF in dedifferentiation of tumor cells expanding its role in cancer beyond its known proangiogenic function...
  26. ncbi Revealing the role of phospholipase Cβ3 in the regulation of VEGF-induced vascular permeability
    Luke H Hoeppner
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Blood 120:2167-73. 2012
    ..Our results suggest an important effect of PLCβ3 on VP and provide a new model with which to identify genetic regulators of VP crucial to several disease processes...
  27. ncbi RGS-GAIP-interacting protein controls breast cancer progression
    Ling Wang
    Department of Biochemistry and Molecular Biology, Gugg 13 21C, Mayo Clinic College of Medicine, 200 First St S W, Rochester, MN 55905, USA
    Mol Cancer Res 8:1591-600. 2010
    ....
  28. ncbi Designing nanoconjugates to effectively target pancreatic cancer cells in vitro and in vivo
    Jameel Ahmad Khan
    Department of Biochemistry and Molecular Biology, College of Medicine, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 6:e20347. 2011
    ..The fundamental parameters for intelligent design of nanoconjugates are on the forefront. The goal of this study is to define the necessary design parameters to successfully target pancreatic cancer cells...
  29. ncbi Protein kinase C-mediated modulation of FIH-1 expression by the homeodomain protein CDP/Cut/Cux
    Jinping Li
    Department of Biochemistry and Molecular Biology, Gugg 1401A, Mayo Clinic College of Medicine, 200 First Street SW, Rochester MN 55905, USA
    Mol Cell Biol 27:7345-53. 2007
    ..Taken together, our results suggest for the first time a potential connection between CDP and FIH that could lead to the development of future therapeutic interventions...
  30. ncbi Neuropilin-1 modulates p53/caspases axis to promote endothelial cell survival
    Ling Wang
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
    PLoS ONE 2:e1161. 2007
    ....
  31. ncbi Lack of an effect of pioglitazone or glipizide on lipoprotein-associated phospholipase A2 in type 2 diabetes
    Ananda Basu
    Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Endocr Pract 13:147-52. 2007
    ....
  32. ncbi Endogenous vascular endothelial growth factor-A (VEGF-A) maintains endothelial cell homeostasis by regulating VEGF receptor-2 transcription
    Guangqi E
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Biol Chem 287:3029-41. 2012
    ..Taken together, our results emphasize the importance of endogenous VEGF-A in endothelial cells by regulating key vascular proteins and maintaining the endothelial homeostasis...
  33. ncbi Fabrication of gold nanoparticles for targeted therapy in pancreatic cancer
    Chitta Ranjan Patra
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA
    Adv Drug Deliv Rev 62:346-61. 2010
    ..In this review, we will discuss how the unique physico-chemical properties of gold nanoparticles may be utilized for targeted drug delivery in pancreatic cancer leading to increased efficacy of traditional chemotherapeutics...
  34. ncbi Hypoxia-induced phenotypic switch of fibroblasts to myofibroblasts through a matrix metalloproteinase 2/tissue inhibitor of metalloproteinase-mediated pathway: implications for venous neointimal hyperplasia in hemodialysis access
    Sanjay Misra
    Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Vasc Interv Radiol 21:896-902. 2010
    ..It was hypothesized that, under hypoxic stimulus (ie, HIF-1alpha), fibroblasts will convert to myofibroblasts through a matrix metalloproteinase (MMP)-2-mediated pathway...
  35. ncbi Targeted delivery of gemcitabine to pancreatic adenocarcinoma using cetuximab as a targeting agent
    Chitta Ranjan Patra
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA
    Cancer Res 68:1970-8. 2008
    ..This strategy could be used as a generalized approach for the treatment of a variety of cancers characterized by overexpression of EGFR...
  36. ncbi Role of AKT-glycogen synthase kinase axis in monocyte activation in human beings with and without type 2 diabetes
    Debashis Nandy
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN, USA
    J Cell Mol Med 14:1396-407. 2010
    ..We conclude that diabetic monocytes show increased migratory capacity in response to GSK-3beta inhibition. GSK inhibitors developed to treat the metabolic complications of diabetes should therefore be used with caution...
  37. ncbi In vivo toxicity studies of europium hydroxide nanorods in mice
    Chitta Ranjan Patra
    Department of Biochemistry and Molecular Biology, 200 First Street S W, Guggenheim 1321A, Mayo Clinic College of Medicine, Mayo Foundation, Rochester, MN 55905, USA
    Toxicol Appl Pharmacol 240:88-98. 2009
    ..Histological examination of nanorod-treated vital organs (liver, kidney, spleen and lungs) showed no or only mild histological changes that indicate mild toxicity at the higher dose of nanorods...
  38. ncbi Chemically modified peptides targeting the PDZ domain of GIPC as a therapeutic approach for cancer
    Chitta Ranjan Patra
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States
    ACS Chem Biol 7:770-9. 2012
    ..This, in conjunction with optimization of targeting through side chain modification, has yielded an approach that will allow the discovery and development of next-generation cellular probes for GIPC PDZ as well as for other PDZ domains...
  39. ncbi Effect of hyperglycemia on human monocyte activation
    Debashis Nandy
    Division of Endocrinology and Metabolism, Mayo Clinic College of Medicine, Rochester, MN, USA
    J Investig Med 59:661-7. 2011
    ..These observations imply that modest hyperglycemia per se, as is commonly observed in diabetic individuals, is a potent stimulator of monocyte activity even without chemokines...
  40. ncbi The novel receptor tyrosine kinase Axl is constitutively active in B-cell chronic lymphocytic leukemia and acts as a docking site of nonreceptor kinases: implications for therapy
    Asish K Ghosh
    Division of Hematology, Mayo Clinic, Rochester, MN 55905, USA
    Blood 117:1928-37. 2011
    ..Therefore, we have identified a novel RTK in CLL B cells which appears to work as a docking site for multiple non-RTKs and drives leukemic cell survival signals. These findings highlight a unique target for CLL treatment...
  41. ncbi Plumbagin inhibits tumorigenesis and angiogenesis of ovarian cancer cells in vivo
    Sutapa Sinha
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN
    Int J Cancer 132:1201-12. 2013
    ..Collectively, our studies indicate that plumbagin, as an anti-cancer agent disrupts growth of ovarian cancer cells through the inhibition of proliferation as well as angiogenesis...
  42. ncbi Neuropilin-1 stimulates tumor growth by increasing fibronectin fibril assembly in the tumor microenvironment
    Usman Yaqoob
    Gastroenterology Research Unit and Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer Res 72:4047-59. 2012
    ..These results not only identify new molecular mechanisms of fibronectin fibril assembly but also have important implications for therapeutic targeting of the myofibroblast in the tumor microenvironment...
  43. ncbi Dopamine inhibits pulmonary edema through the VEGF-VEGFR2 axis in a murine model of acute lung injury
    Pawan K Vohra
    Dept of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Guggenheim 1334, 200 First St S W, Rochester, MN 55905, USA
    Am J Physiol Lung Cell Mol Physiol 302:L185-92. 2012
    ..Taken together, our results suggest that dopamine acts through D2DR to inhibit pulmonary edema-associated vascular permeability, which is mediated through VEGF-VEGFR2 signaling and conveys protective effects in an ALI model...
  44. ncbi Assessment of wall shear stress changes in arteries and veins of arteriovenous polytetrafluoroethylene grafts using magnetic resonance imaging
    Sanjay Misra
    Department of Radiology, Mayo Clinic, Rochester, MN, USA
    Cardiovasc Intervent Radiol 29:624-9. 2006
    ..High blood flows through the AA causes a decrease in average WSS and increase in the average luminal vessel area, whereas at the AV, the average WSS and intima-to-media ratio both increase while the average luminal vessel area decreases...
  45. ncbi Pancreatic stellate cell models for transcriptional studies of desmoplasia-associated genes
    Angela Mathison
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minn, USA
    Pancreatology 10:505-16. 2010
    ..The cells are scarce in the pancreas making their isolation time and resource use consuming...
  46. ncbi Ephrin B2/EphB4 pathway in hepatic stellate cells stimulates Erk-dependent VEGF production and sinusoidal endothelial cell recruitment
    Amitava Das
    Gastroenterology Research Unit, Mayo Clinic and Foundation, 200 First St SW, Rochester, MN 55905, USA
    Am J Physiol Gastrointest Liver Physiol 298:G908-15. 2010
    ..These studies identify EphrinB2 or EphB4 as a key intermediary that links HSC signal transduction pathways with angiogenesis and sinusoidal remodeling...
  47. ncbi The rat femoral arteriovenous fistula model: increased expression of matrix metalloproteinase-2 and -9 at the venous stenosis
    Sanjay Misra
    Department of Radiology, Mayo Clinic College of Medicine, 200 First Street Southwest, Alfred 6460, Rochester, MN 55905, USA
    J Vasc Interv Radiol 19:587-94. 2008
    ....
  48. ncbi Expression and regulatory role of GAIP-interacting protein GIPC in pancreatic adenocarcinoma
    Michael H Muders
    Department of Biochemistry and Molecular Biology, Mayo Clinic Cancer Center, Rochester, Minnesota 55905, USA
    Cancer Res 66:10264-8. 2006
    ..Taken together, our data suggest that GIPC is a central molecule for the stability of IGF-IR and could be a target for future therapy...
  49. ncbi Both vascular endothelial growth factor and soluble Flt-1 are increased in type 2 diabetes but not in impaired fasting glucose
    Debashis Nandy
    Division of Endocrinology and Metabolism, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Investig Med 58:804-6. 2010
    ..Vascular endothelial growth factor (VEGF) and its regulatory molecule soluble Flt-1(sFlt-1) play important roles in atherogenesis...
  50. ncbi Von Hippel-Lindau gene product directs cytokinesis: a new tumor suppressor function
    Sutapa Sinha
    Department of Biochemistry and Molecular Biology, Mayo Clinic Foundation, Rochester, MN 55905, USA
    J Cell Sci 124:2132-42. 2011
    ..Thus, this study offers a way to explain the chromosome instability in RCC and reveals a new direction for the tumor suppressor function of pVHL, which is independent of its E3 ubiquitin ligase activity...
  51. ncbi A lipid-modified estrogen derivative that treats breast cancer independent of estrogen receptor expression through simultaneous induction of autophagy and apoptosis
    Sutapa Sinha
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Guggenheim 1321, 200 First St S W, Rochester, MN 55905, USA
    Mol Cancer Res 9:364-74. 2011
    ..Together, our results open new perspective of breast cancer chemotherapy through a single agent, which could provide the therapeutic benefit across all stages of breast cancer...
  52. ncbi Nitric oxide promotes endothelial cell survival signaling through S-nitrosylation and activation of dynamin-2
    Ningling Kang Decker
    GI Research Unit, Department of Physiology and Tumor Biology Program, Mayo Clinic, Rochester, MN 55903, USA
    J Cell Sci 120:492-501. 2007
    ....
  53. ncbi Role of elongin-binding domain of von Hippel Lindau gene product on HuR-mediated VPF/VEGF mRNA stability in renal cell carcinoma
    Kaustubh Datta
    Department of Biochemistry and Molecular Biology and Mayo Clinic Cancer Center, Mayo Clinic Foundation, Rochester, MN 55905, USA
    Oncogene 24:7850-8. 2005
    ..The experiments presented here suggest that the association of the elongin-binding domain of VHL with a specific RNA-binding domain of HuR (RRM1) is important for the destabilizing function of VHL on VPF/VEGF mRNA...
  54. ncbi Tissue factor pathway inhibitor blocks angiogenesis via its carboxyl terminus
    Eric W Holroyd
    Division of Cardiovascular Diseases, Department of Biochemistry and Molecular Biology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Arterioscler Thromb Vasc Biol 32:704-11. 2012
    ..TFPI may also affect angiogenesis independently of TF, through sequences within its polybasic carboxyl terminus (TFPI C terminus [TFPIct]). We aimed to determine the effects of TFPI on angiogenesis and the role of TFPIct...
  55. ncbi Sclerostin binds and regulates the activity of cysteine-rich protein 61
    Theodore A Craig
    Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Biochem Biophys Res Commun 392:36-40. 2010
    ..The data show that sclerostin binds to and influences the activity of Cyr61...
  56. ncbi The porcine remnant kidney model of chronic renal insufficiency
    Sanjay Misra
    Department of Radiology, Division of Vascular Surgery, Mayo Clinic, Rochester, Minnesota 55905
    J Surg Res 135:370-9. 2006
    ..The purpose of the present study was to develop and characterize a porcine model of chronic renal insufficiency created by renal artery embolization...
  57. ncbi Regulation of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF-A) expression in podocytes
    Kaustubh Datta
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Kidney Int 66:1471-8. 2004
    ..We hypothesized that the glomerular basement membrane (GBM) matrix-podocyte interaction may play a role in the constitutive expression of VPF/VEGF-A in the adult glomerulus...
  58. ncbi DNA conjugated SWCNTs enter endothelial cells via Rac1 mediated macropinocytosis
    Santanu Bhattacharya
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Nano Lett 12:1826-30. 2012
    ..Additionally, by using pharmacological inhibitors as well as genetic approaches, we have found that SWCNT is endocytosed through Rac1- GTPase mediated macropinocytosis in normal endothelial cells...
  59. ncbi Aberrant regulation of pVHL levels by microRNA promotes the HIF/VEGF axis in CLL B cells
    Asish K Ghosh
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Blood 113:5568-74. 2009
    ..This is initial evidence that pVHL, without any genetic alteration, can be regulated by microRNA and explains the aberrant autocrine VEGF secretion in CLL...
  60. ncbi C terminus of RGS-GAIP-interacting protein conveys neuropilin-1-mediated signaling during angiogenesis
    Ling Wang
    Department Biochemistry and Molecular Biology, Gugg 1401A, Mayo Clinic College of Medicine, 200 First St SW, Rochester, Minnesota 55905, USA
    FASEB J 20:1513-5. 2006
    ..Taken together, our data suggest a novel role of GIPC in angiogenesis and vessel formation and also support our hypothesis that NRP-1 can facilitate downstream signaling to promote angiogenesis through GIPC...
  61. ncbi Lanthanide phosphate nanorods as inorganic fluorescent labels in cell biology research
    Chitta Ranjan Patra
    Department of Biochemistry and Molecular Biology, Mayo Clinic Cancer Center, Mayo Clinic, Rochester, MN, USA
    Clin Chem 53:2029-31. 2007
  62. ncbi Circulating microvesicles in B-cell chronic lymphocytic leukemia can stimulate marrow stromal cells: implications for disease progression
    Asish K Ghosh
    Division of Hematology, Mayo Clinic, Rochester, MN, USA
    Blood 115:1755-64. 2010
    ..This study demonstrates the existence of separate MV phenotypes during leukemic disease progression and underscores the important role of MVs in activation of the tumor microenvironment...
  63. ncbi Adrenomedullin is Up-regulated in Patients With Pancreatic Cancer and Causes Insulin Resistance in β Cells and Mice
    Gaurav Aggarwal
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota
    Gastroenterology 143:1510-1517.e1. 2012
    ..New-onset diabetes in patients with pancreatic cancer is likely to be a paraneoplastic phenomenon caused by tumor-secreted products. We aimed to identify the diabetogenic secretory product(s) of pancreatic cancer...
  64. ncbi Precise scheduling of chemotherapy primes VEGF-producing tumors for successful systemic oncolytic virotherapy
    Timothy Kottke
    Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Mol Ther 19:1802-12. 2011
    ....
  65. ncbi Increased expression of a disintegrin and metalloproteinase thrombospondin 1 in thrombosed hemodialysis grafts
    Sanjay Misra
    Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
    J Vasc Interv Radiol 19:111-9. 2008
    ..One of these significantly upregulated proteins was a disintegrin and metalloproteinase thrombospondin-1 (ADAMTS-1), and its expression and activity were determined in thrombosed hemodialysis grafts...
  66. ncbi A functional family-wide screening of SP/KLF proteins identifies a subset of suppressors of KRAS-mediated cell growth
    Martin E Fernandez-Zapico
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55901, USA
    Biochem J 435:529-37. 2011
    ....
  67. ncbi The use of microorganisms for the formation of metal nanoparticles and their application
    Deendayal Mandal
    Department of Orthopedics, Mayo Clinic and Foundation, 200 First Street SW, Medical Sciences Building 3 103, Rochester, MN 55905, USA
    Appl Microbiol Biotechnol 69:485-92. 2006
    ..This review describes a brief overview of the current research worldwide on the use of microorganisms in the biosynthesis of metal nanoparticles and their applications...
  68. ncbi Angiogenesis in atherogenesis
    Joerg Herrmann
    Division of Cardiovascular Diseases, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Arterioscler Thromb Vasc Biol 26:1948-57. 2006
    ..This article gives an updated overview on this topic and briefly reflects on the similarities with neovessel formation in carcinogenesis...
  69. ncbi Adventitial remodeling with increased matrix metalloproteinase-2 activity in a porcine arteriovenous polytetrafluoroethylene grafts
    Sanjay Misra
    Department of Radiology, Division of Vascular Surgery, Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Kidney Int 68:2890-900. 2005
    ....
  70. ncbi Ablation of peripheral dopaminergic nerves stimulates malignant tumor growth by inducing vascular permeability factor/vascular endothelial growth factor-mediated angiogenesis
    Sujit Basu
    Department of Biochemistry and Molecular Biology and Mayo Clinic Cancer Center, Mayo Clinic Foundation, Rochester, Minnesota 55905, USA
    Cancer Res 64:5551-5. 2004
    ....
  71. ncbi Effects of pioglitazone versus glipizide on body fat distribution, body water content, and hemodynamics in type 2 diabetes
    Ananda Basu
    Division of Endocrinology and Metabolism, 200 First Street SW, Rochester, MN 55905, USA
    Diabetes Care 29:510-4. 2006
    ..Our study was designed to examine the effects of pioglitazone versus glipizide on body water, body composition, and hemodynamic parameters in the presence of comparable glycemic control between groups...
  72. ncbi Effect of insulin deprivation on muscle mitochondrial ATP production and gene transcript levels in type 1 diabetic subjects
    Helen Karakelides
    Division of Endocrinology and Metabolism and Endocrine Research Unit, Mayo Clinic, 200 First St SW, Joseph 5 194, Rochester, MN 55905, USA
    Diabetes 56:2683-9. 2007
    ..We determined the impact of insulin deficiency on muscle mitochondrial ATP production by temporarily depriving type 1 diabetic patients of insulin treatment...
  73. ncbi Absence of histologic retinal toxicity of intravitreal nanogold in a rabbit model
    Sophie J Bakri
    Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA
    Retina 28:147-9. 2008
    ..To evaluate the retinal toxicity of intravitreal nanogold, a novel antiangiogenic and long-term delivery agent...
  74. ncbi Requirement of different signaling pathways mediated by insulin-like growth factor-I receptor for proliferation, invasion, and VPF/VEGF expression in a pancreatic carcinoma cell line
    Huiyan Zeng
    Department of Pathology, RN270H, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, MA 02215, USA
    Biochem Biophys Res Commun 302:46-55. 2003
    ..Taken together, our data indicate the importance of IGF-IR in growth and invasiveness of the pancreatic cancer cell lines and also point out the multiple signaling pathways channeled through this receptor...
  75. ncbi Heterotrimeric G alpha q/G alpha 11 proteins function upstream of vascular endothelial growth factor (VEGF) receptor-2 (KDR) phosphorylation in vascular permeability factor/VEGF signaling
    Huiyan Zeng
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 278:20738-45. 2003
    ..Taken together, this study demonstrates that Gq/11 proteins mediate KDR tyrosine phosphorylation and KDR-mediated HUVEC proliferation through interaction with KDR...
  76. ncbi Neuropilin-1-mediated vascular permeability factor/vascular endothelial growth factor-dependent endothelial cell migration
    Ling Wang
    Department of Pathology, Beth Israel Deaconess Medical Center, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 278:48848-60. 2003
    ..These results show for the first time that NRP-1 can independently promote cell signaling in endothelial cells and also demonstrate the importance of last three amino acids of NRP-1 for its function...
  77. ncbi Role of insulin receptor substrates and protein kinase C-zeta in vascular permeability factor/vascular endothelial growth factor expression in pancreatic cancer cells
    Matthias Neid
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 279:3941-8. 2004
    ..Our data also suggest that IRS proteins, which are known to play crucial roles in IGF-1R signaling, are also important mediators for tumor angiogenesis...
  78. ncbi Multiple regulatory pathways of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) expression in tumors
    Debabrata Mukhopadhyay
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Semin Cancer Biol 14:123-30. 2004
    ..In this article, we discuss different regulatory pathways in tumor cells comprised of oncogenes, tumor suppressor genes etc. that play important roles, in both the transcription and stability of VPF/VEGF mRNA...
  79. ncbi Myogenic Akt signaling regulates blood vessel recruitment during myofiber growth
    Akihiro Takahashi
    Division of Cardiovascular Research, St Elizabeth s Medical Center of Boston, School of Medicine, Tufts University, 02135, USA
    Mol Cell Biol 22:4803-14. 2002
    ..These data suggest that myogenic Akt signaling controls both fiber hypertrophy and angiogenic growth factor synthesis, illustrating a mechanism through which blood vessel recruitment can be coupled to normal tissue growth...
  80. ncbi Inhibition of vascular permeability factor/vascular endothelial growth factor-mediated angiogenesis by the Kruppel-like factor KLF2
    Resham Bhattacharya
    Program in Cardiovascular Transcriptional Biology, Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Biol Chem 280:28848-51. 2005
    ..This effect is due to a potent inhibition of VEGFR2/KDR expression and promoter activity. These observations identify KLF2 as a regulator of VEGFR2/KDR and provide a foundation for novel approaches to regulate angiogenesis...
  81. ncbi Flt-1-mediated down-regulation of endothelial cell proliferation through pertussis toxin-sensitive G proteins, beta gamma subunits, small GTPase CDC42, and partly by Rac-1
    Huiyan Zeng
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard University School of Medicine, Boston, Massachusetts 02215, USA
    J Biol Chem 277:4003-9. 2002
    ..Taken together, these results further expand our understanding of Flt-1-mediated antiproliferative activity in VPF/VEGF-stimulated endothelium...
  82. ncbi Effect of rapamycin alone and in combination with antiangiogenesis therapy in an orthotopic model of human pancreatic cancer
    Susann Stephan
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Clin Cancer Res 10:6993-7000. 2004
    ....
  83. ncbi Inhibition of vessel permeability by TNP-470 and its polymer conjugate, caplostatin
    Ronit Satchi-Fainaro
    Children s Hospital Boston and Harvard Medical School, Vascular Biology Program, Department of Surgery, 1 Blackfan Circle, Karp Family Research Laboratories, Floor 12, Boston, Massachusetts 02115, USA
    Cancer Cell 7:251-61. 2005
    ..This activity likely contributes to TNP-470's antiangiogenic effect and suggests that caplostatin can be used in the treatment of cancer and inflammation...
  84. ncbi Vascular endothelial growth factor impairs the functional ability of dendritic cells through Id pathways
    Sreenivas Laxmanan
    Department of Pathology, Beth Israel Deaconess Medical Center School, Harvard Medical School, Boston, MA, USA
    Biochem Biophys Res Commun 334:193-8. 2005
    ..Thus, the role of VEGF in downregulating host immunity may highlight a unique role of VEGF in the pathogenesis of cancer...
  85. ncbi Direct evidence for endothelial vascular endothelial growth factor receptor-1 function in nitric oxide-mediated angiogenesis
    Shakil Ahmad
    Department of Reproductive and Vascular Biology, Institute for Biomedical Research, The Medical School, University of Birmingham, Birmingham B15 2TT, UK
    Circ Res 99:715-22. 2006
    ..These studies provide new sites of modulation in VEGF-mediated vascular morphogenesis and highlight new therapeutic targets for management of vascular diseases...
  86. ncbi KDR stimulates endothelial cell migration through heterotrimeric G protein Gq/11-mediated activation of a small GTPase RhoA
    Huiyan Zeng
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 277:46791-8. 2002
    ..Taken together, our results indicate that KDR stimulates endothelial cell migration through a heterotrimeric G protein Gq/11 and Gbetagamma-mediated RhoA pathway...
  87. ncbi CD40-induced transcriptional activation of vascular endothelial growth factor involves a 68-bp region of the promoter containing a CpG island
    Peter H Lapchak
    The Division of Nephrology, Department of Medicine, Children s Hospital, Boston, MA 02115, USA
    Am J Physiol Renal Physiol 287:F512-20. 2004
    ..Taken together, this is the first demonstration that CpG binding transcriptional repressor proteins including MeCP2 may be of importance in VEGF biology...
  88. ncbi Proinflammatory functions of vascular endothelial growth factor in alloimmunity
    Marlies E J Reinders
    Division of Nephrology, Department of Medicine, Children's Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    J Clin Invest 112:1655-65. 2003
    ..Thus, VEGF appears to be functional in acute allograft rejection via its effects on leukocyte trafficking. Together, these observations provide mechanistic insight into the proinflammatory function of VEGF in immunity...
  89. ncbi Protein kinase C zeta transactivates hypoxia-inducible factor alpha by promoting its association with p300 in renal cancer
    Kaustubh Datta
    Departmens of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Cancer Res 64:456-62. 2004
    ....
  90. ncbi Vascular endothelial growth factor and semaphorin induce neuropilin-1 endocytosis via separate pathways
    Anna Salikhova
    Angiogenesis Research Center, Dartmouth Medical School, Lebanon, NH 03756, USA
    Circ Res 103:e71-9. 2008
    ..These results show that the endocytic pathway of Nrp1 is determined by its ligand and that the trafficking of Nrp1 is essential for its signaling...

Research Grants21

  1. Distinct Pathways of VPF/VEGF Receptors
    Debabrata Mukhopadhyay; Fiscal Year: 2005
    ..Taken together these experiments are likely to identify new therapeutic targets in order to combat angiogenesis in tumors and also in other disease processes. ..
  2. REGULATORY PATHWAYS AND ROLE OF VPF/VEGF IN RENAL CANCER
    Debabrata Mukhopadhyay; Fiscal Year: 2009
    ....
  3. Distinct Pathways of VPF/VEGF Receptors
    Debabrata Mukhopadhyay; Fiscal Year: 2007
    ..Hence, the results of these proposed studies will help identify potential angiogenic inhibitors or promoters that can be targeted and used to improve future therapies against different diseases. ..
  4. REGULATORY PATHWAYS AND ROLE OF VPF/VEGF IN RENAL CANCER
    Debabrata Mukhopadhyay; Fiscal Year: 2007
    ....
  5. Distinct Pathways of VPF/VEGF Receptors
    Debabrata Mukhopadhyay; Fiscal Year: 2010
    ..Hence, the results of these proposed studies will help identify potential angiogenic inhibitors or promoters that can be targeted and used to improve future therapies against different diseases. ..
  6. Targeting Pancreatic Cancer Using Peptide Chemistry: From Bench to Bedside
    Mark R Spaller; Fiscal Year: 2010
    ..The proposed study might define the mechanism of pancreatic cancer growth and progression and identify specific targets for therapeutic interventions for pancreatic adenocarcinoma where no current therapy is available. ..
  7. The Neurotransmitter dopamine and angiogenesis
    Debabrata Mukhopadhyay; Fiscal Year: 2007
    ..abstract_text> ..
  8. Neurotransmitter dopamine and angiogenesis
    Debabrata Mukhopadhyay; Fiscal Year: 2003
    ..abstract_text> ..
  9. The Neurotransmitter dopamine and angiogenesis
    Debabrata Mukhopadhyay; Fiscal Year: 2006
    ..abstract_text> ..
  10. REGULATORY PATHWAYS AND ROLE OF VPF/VEGF IN RENAL CANCER
    Debabrata Mukhopadhyay; Fiscal Year: 2010
    ....