Research Topics
| William G MoriceSummaryAffiliation: Mayo Clinic Country: USA Publications
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Detail Information
Publications
Distinct bone marrow findings in T-cell granular lymphocytic leukemia revealed by paraffin section immunoperoxidase stains for CD8, TIA-1, and granzyme BWilliam G Morice
Division of Hematopathology, Mayo Clinic, Rochester, MN 55905, USA
Blood 99:268-74. 2002..These findings clarify the bone marrow histopathology of T-cell GLL and provide an additional tool by which the discrete, abnormal lymphocyte population required for a diagnosis of T-cell GLL can be identified...- Diffuse large B-cell lymphoma with distinctive patterns of splenic and bone marrow involvement: clinicopathologic features of two casesWilliam G Morice
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
Mod Pathol 18:495-502. 2005.... 
Predictive value of blood and bone marrow flow cytometry in B-cell lymphoma classification: comparative analysis of flow cytometry and tissue biopsy in 252 patientsWilliam G Morice
Division of Hematopathology, Mayo Clinic, Rochester, MN 55905, USA
Mayo Clin Proc 83:776-85. 2008..To study the effectiveness of peripheral blood (PB) and bone marrow flow cytometric immunophenotyping (FCIP) in predicting the histologic B-cell lymphoma type...- Novel immunophenotypic features of marrow lymphoplasmacytic lymphoma and correlation with Waldenström's macroglobulinemiaWilliam G Morice
Division of Hematopathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
Mod Pathol 22:807-16. 2009..Apart from this, no other pathological correlates of the clinical or laboratory features of symptomatic Waldenström's macroglobulinemia were identified... - The expression of the novel cytotoxic protein granzyme M by large granular lymphocytic leukaemias of both T-cell and NK-cell lineage: an unexpected finding with implications regarding the pathobiology of these disordersWilliam G Morice
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
Br J Haematol 137:237-9. 2007..These unexpected results suggest commonality between T- and NK-LGL, providing further support to the notion that T-LGL is a disorder of dysregulated, chronically stimulated, adaptive cytotoxic T-cells... - Demonstration of aberrant T-cell and natural killer-cell antigen expression in all cases of granular lymphocytic leukaemiaWilliam G Morice
Division of Hematopathology, Mayo Clinic, Rochester, MN 55905, USA
Br J Haematol 120:1026-36. 2003..These studies delineate the unique immunophenotypic features diagnostic of T-GLL and provide strong evidence that NK-GLL, like T-GLL, represents a clonal lymphoproliferative disorder... 
B-cell count and survival: differentiating chronic lymphocytic leukemia from monoclonal B-cell lymphocytosis based on clinical outcomeTait D Shanafelt
Mayo Clinic, Rochester, MN, USA
Blood 113:4188-96. 2009..Using clinically relevant criteria to distinguish between monoclonal B-cell lymphocytosis (MBL) and CLL could minimize patient distress caused by labeling asymptomatic people at low risk for adverse clinical consequences as having CLL...- CD5-positive chronic B-cell lymphoproliferative disorders: diagnosis and prognosis of a heterogeneous disease entityRoxana S Dronca
Division of Hematology, Mayo Clinic, Rochester, Minnesota 55905, USA
Cytometry B Clin Cytom 78:S35-41. 2010..e. CD5+B-CLPD) are poorly defined... - CD5+ B-cell lymphoproliferative disorders: Beyond chronic lymphocytic leukemia and mantle cell lymphomaDragan Jevremovic
Division of Hematopathology, Mayo Clinic, 200 1 st Street SW, Hilton 8200, Rochester, MN 55905, USA
Leuk Res 34:1235-8. 2010..Applying strict flow cytometry criteria, using genetic studies, and deferring to a lymph node/tissue diagnosis in non-classical cases are critical for accurate diagnosis and classification of CD5+ B-cell LPD... - Inflammatory pseudotumor of the spleen associated with a clonal Epstein-Barr virus genome. Case report and review of the literatureJason T Lewis
Dept of Pathology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
Am J Clin Pathol 120:56-61. 2003..The presence of clonal EBV DNA suggests some splenic IPTs may be true neoplasms... - Bone marrow histopathology in POEMS syndrome: a distinctive combination of plasma cell, lymphoid, and myeloid findings in 87 patientsLinda N Dao
Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Blood 117:6438-44. 2011.... - The immunophenotypic attributes of NK cells and NK-cell lineage lymphoproliferative disordersWilliam G Morice
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
Am J Clin Pathol 127:881-6. 2007.... - Brief report: natural history of individuals with clinically recognized monoclonal B-cell lymphocytosis compared with patients with Rai 0 chronic lymphocytic leukemiaTait D Shanafelt
Mayo Clinic, Rochester, MN 55905, USA
J Clin Oncol 27:3959-63. 2009..The natural history of clinically identified MBL is unclear. The goal of this study was to explore the outcome of patients with MBL relative to that of individuals with Rai stage 0 chronic lymphocytic leukemia (CLL)... - Expression of cytolytic lymphocyte-associated antigens in pulmonary lymphomatoid granulomatosisWilliam G Morice
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
Am J Clin Pathol 118:391-8. 2002.... - Human leucocyte antigen class I and killer immunoglobulin-like receptor expression patterns in T-cell large granular lymphocyte leukaemiaGrzegorz S Nowakowski
Department of Hematology, Mayo Clinic, Rochester, MN 55905, USA
Br J Haematol 128:490-2. 2005..Cytopenias occurred in all five 'mismatch' patients but not in two patients with 'match', suggesting that KIR/HLA-I mismatch may contribute to the suppression of haematopoiesis... - Spectrum of bone marrow findings in patients with angioimmunoblastic T-cell lymphomaKaren L Grogg
Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Br J Haematol 137:416-22. 2007..In two cases, these changes obscured the presence of BM involvement by AITL. The spectrum of BM findings in AITL patients is important to recognise for early and accurate diagnosis in this disease... - A comparison of morphologic features, flow cytometry, TCR-Vbeta analysis, and TCR-PCR in qualitative and quantitative assessment of peripheral blood involvement by Sézary syndromeWilliam G Morice
Division of Hematopathology, Mayo Clinic, Rochester, MN 55905, USA
Am J Clin Pathol 125:364-74. 2006.... - Clinical features in T-cell vs. natural killer-cell variants of large granular lymphocyte leukemiaMichelle A Neben
Division of Hematology and Internal Medicine; Division of Hematopathology, Mayo Clinic, Mayo Medical School, Rochester, MN 55905, USA
Eur J Haematol 71:263-5. 2003..04) and a higher frequency of palpable splenomegaly (P < 0.01). CONCLUSION: Overall disease progression and response to immunosuppressive therapy are similar between T-cell and natural killer-cell variants of LGLL... - An unusual case of leukemic mantle cell lymphoma with a blastoid component showing loss of CD5 and aberrant expression of CD10William G Morice
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
Am J Clin Pathol 122:122-7. 2004..This case illustrates the phenotypic heterogeneity of MCL and underscores the need for histopathologic correlation and, in some instances, ancillary genetic studies to accurately classify B-cell lymphomas... - MBL or CLL: which classification best categorizes the clinical course of patients with an absolute lymphocyte count >or= 5 x 10(9) L(-1) but a B-cell lymphocyte count <5 x 10(9) L(-1)?Tait D Shanafelt
Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, United States
Leuk Res 32:1458-61. 2008..In contrast, CD38 predicted TTT (p=0.02) regardless of the proposed new classification. Molecular characteristics of the leukemic clone are a better predictor of progression than an arbitrary ALC or B lymphocyte count threshold... - Clinical significance of monoclonal B cells in cerebrospinal fluidGrzegorz S Nowakowski
Division of Hematology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
Cytometry B Clin Cytom 63:23-7. 2005..Although flow cytometry is increasingly used to detect a monoclonal B-cell population in the CSF, the significance of this finding in the absence of morphologically identifiable malignant cells is unknown... - Immunophenotypic attributes of benign peripheral blood gammadelta T cells and conditions associated with their increaseAnja C Roden
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN55905, USA
Arch Pathol Lab Med 132:1774-80. 2008..In comparison to alphabeta T cells, little is known about the immunophenotype of healthy peripheral blood gammadelta T cells or about conditions associated with expansion of this usually minor T-cell subset... - Flow cytometric assessment of TCR-Vbeta expression in the evaluation of peripheral blood involvement by T-cell lymphoproliferative disorders: a comparison with conventional T-cell immunophenotyping and molecular genetic techniquesWilliam G Morice
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
Am J Clin Pathol 121:373-83. 2004..TCR-Vbeta flow cytometric analysis is a powerful clinical laboratory tool that can be used to aid in the rapid diagnosis of peripheral blood involvement by T-cell malignant neoplasms... - Flow cytometric assessment of T-cell chronic lymphoproliferative disordersFrancois M Cady
Division of Hematopathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA
Clin Lab Med 27:513-32, vi. 2007.... - Comparison of fluorescence in situ hybridization, p57 immunostaining, flow cytometry, and digital image analysis for diagnosing molar and nonmolar products of conceptionBenjamin R Kipp
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
Am J Clin Pathol 133:196-204. 2010..These data suggest that the combination of p57 and FISH seems to be the best ancillary testing strategy to aid pathologists in the appropriate identification of CM, PM, and HA in POC specimens... - Establishment and characterization of a novel Waldenstrom macroglobulinemia cell line, MWCL-1Lucy S Hodge
Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN, USA
Blood 117:e190-7. 2011..The genetic, immunophenotypic, and biologic data presented here confirm the validity of the MWCL-1 cell line as a representative model of WM... - Chronic basophilic leukemia: a distinct clinico-pathologic entity?Animesh D Pardanani
Divisions of Hematology and Internal Medicine, Hematopathology, Mayo Clinic, Rochester, MN 55905, USA
Eur J Haematol 71:18-22. 2003..We sought to better define a group of rare and poorly understood myeloproliferative disorders that are characterized by prominent chronic basophilia in the absence of the Philadelphia chromosome (Ph) or its molecular equivalent... - Immunohistochemical phenotyping of plasma cells in lymphoplasmacytic lymphoma/Waldenström's macroglobulinemia is comparable to flow cytometric techniquesMatthew T Howard
Division of Hematopathology, Mayo Clinic, Rochester, Minnesota, USA
Clin Lymphoma Myeloma Leuk 11:96-8. 2011..The results indicate that immunohistochemistry yields results comparable to flow cytometry, and suggests that using both modalities in parallel compensates for the shortcomings of each... - Diagnosis and management of Waldenström macroglobulinemia: Mayo stratification of macroglobulinemia and risk-adapted therapy (mSMART) guidelinesStephen M Ansell
Division of Hematology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
Mayo Clin Proc 85:824-33. 2010..Autologous stem cell transplant should be considered in all eligible patients with relapsed disease... - Hemophagocytosis in a patient with chronic lymphocytic leukemia and histoplasmosisRavi D Rao
Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, Minn 55905, USA
Mayo Clin Proc 77:287-90. 2002..Clinical manifestations include signs and symptoms of immune activation and decreased peripheral blood cell counts. This condition is often underdiagnosed because clinicians are unfamiliar with it... - Anti-CD20 monoclonal antibody therapy in multiple myelomaPrashant Kapoor
Division of Hematology, Mayo Clinic, Rochester, MN 55905, USA
Br J Haematol 141:135-48. 2008..Further large-scale clinical trials are therefore needed to establish the role of this promising strategy in the treatment of myeloma... - The clinical and laboratory approach to the CD5/CD10 negative B-cell chronic lymphoproliferative leukemiasCurtis A Hanson
Am J Hematol 83:347-8. 2008 - Bone marrow histopathology in peripheral T-cell lymphomasAhmet Dogan
Department of Histopathology, University College London, London, UK
Br J Haematol 127:140-54. 2004..In this article we review the histopathology of bone marrow biopsy in PTCL within the context of the new WHO classification...