V M Miller

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Human-derived nanoparticles and vascular response to injury in rabbit carotid arteries: proof of principle
    Maria A K Schwartz
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Int J Nanomedicine 3:243-8. 2008
  2. pmc Leukocyte- and platelet-derived microvesicle interactions following in vitro and in vivo activation of toll-like receptor 4 by lipopolysaccharide
    Jing Xiong
    Department of Physiology, China Pharmaceutical University, Nanjing, Jiangsu, China
    PLoS ONE 6:e25504. 2011
  3. doi request reprint Should there be sex-specific criteria for the diagnosis and treatment of heart failure?
    Lawrence E Greiten
    Department of Surgery, Mayo Clinic, Med Sci 4 62, 200 First St SW, Rochester, MN, 55905, USA
    J Cardiovasc Transl Res 7:139-55. 2014
  4. pmc Embedding concepts of sex and gender health differences into medical curricula
    Virginia M Miller
    Department of Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Womens Health (Larchmt) 22:194-202. 2013
  5. pmc Sex-specific risk of cardiovascular disease and cognitive decline: pregnancy and menopause
    Virginia M Miller
    Departments of Surgery and Physiology and Biomedical Engineering, 200 1st St SW, Rochester, MN 55905, USA
    Biol Sex Differ 4:6. 2013
  6. pmc Genetic polymorphisms associated with carotid artery intima-media thickness and coronary artery calcification in women of the Kronos Early Estrogen Prevention Study
    Virginia M Miller
    Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA
    Physiol Genomics 45:79-88. 2013
  7. doi request reprint Evaluating sex and gender competencies in the medical curriculum: a case study
    Virginia M Miller
    Department of Surgery, Mayo Clinic, Rochester, MN 55905, USA
    Gend Med 9:180-186.e3. 2012
  8. pmc Strategies and methods to study sex differences in cardiovascular structure and function: a guide for basic scientists
    Virginia M Miller
    Departments of Surgery, Physiology and Biomedical Engineering, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA
    Biol Sex Differ 2:14. 2011
  9. pmc Alterations in platelet function and cell-derived microvesicles in recently menopausal women: relationship to metabolic syndrome and atherogenic risk
    Muthuvel Jayachandran
    Department of Physiology and Biomedical Engineering, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    J Cardiovasc Transl Res 4:811-22. 2011
  10. pmc Vascular actions of estrogens: functional implications
    Virginia M Miller
    Surgery and Physiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Pharmacol Rev 60:210-41. 2008

Research Grants

  1. Estrogen, Platelets, and Artherosclerosis
    VIRGINIA MILLER; Fiscal Year: 2009
  2. ESTROGEN STATUS AND THE FUNCTION OF CORONARY ARTERIES
    VIRGINIA MILLER; Fiscal Year: 2002
  3. ESTROGEN STATUS AND THE FUNCTION OF CORONARY ARTERIES
    VIRGINIA MILLER; Fiscal Year: 2001
  4. ESTROGEN STATUS AND THE FUNCTION OF CORONARY ARTERIES
    VIRGINIA MILLER; Fiscal Year: 1999
  5. ESTROGEN STATUS AND THE FUNCTION OF CORONARY ARTERIES
    VIRGINIA MILLER; Fiscal Year: 2000
  6. Estrogen, Platelets, and Artherosclerosis
    Whyte G Owen; Fiscal Year: 2010

Collaborators

Detail Information

Publications85

  1. pmc Human-derived nanoparticles and vascular response to injury in rabbit carotid arteries: proof of principle
    Maria A K Schwartz
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Int J Nanomedicine 3:243-8. 2008
    ..This study offers the first evidence that there may be a causal relationship between human-derived nanoparticles and response to injury including calcification in arteries with damaged endothelium...
  2. pmc Leukocyte- and platelet-derived microvesicle interactions following in vitro and in vivo activation of toll-like receptor 4 by lipopolysaccharide
    Jing Xiong
    Department of Physiology, China Pharmaceutical University, Nanjing, Jiangsu, China
    PLoS ONE 6:e25504. 2011
    ..Experiments were designed to evaluate the time course and mechanism of direct interactions between platelets and leukocytes following acute activation of TLR4 by bacterial lipopolysaccharide (LPS)...
  3. doi request reprint Should there be sex-specific criteria for the diagnosis and treatment of heart failure?
    Lawrence E Greiten
    Department of Surgery, Mayo Clinic, Med Sci 4 62, 200 First St SW, Rochester, MN, 55905, USA
    J Cardiovasc Transl Res 7:139-55. 2014
    ....
  4. pmc Embedding concepts of sex and gender health differences into medical curricula
    Virginia M Miller
    Department of Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Womens Health (Larchmt) 22:194-202. 2013
    ..This report summarizes these proceedings, recommendations, and action items from the workshop...
  5. pmc Sex-specific risk of cardiovascular disease and cognitive decline: pregnancy and menopause
    Virginia M Miller
    Departments of Surgery and Physiology and Biomedical Engineering, 200 1st St SW, Rochester, MN 55905, USA
    Biol Sex Differ 4:6. 2013
    ..Research into specific sex differences for these disease processes with attention to an individual's sex chromosomal complement and hormonal status is important and timely...
  6. pmc Genetic polymorphisms associated with carotid artery intima-media thickness and coronary artery calcification in women of the Kronos Early Estrogen Prevention Study
    Virginia M Miller
    Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA
    Physiol Genomics 45:79-88. 2013
    ..51, P value = 2.51 × 10(-04)) associated negatively; none remained significant after correcting for multiple testing. Whether these SNPs associate with CIMT and CAC in women randomized to MHT remains to be determined...
  7. doi request reprint Evaluating sex and gender competencies in the medical curriculum: a case study
    Virginia M Miller
    Department of Surgery, Mayo Clinic, Rochester, MN 55905, USA
    Gend Med 9:180-186.e3. 2012
    ..Sex and gender differences exist in the manifestation and prevalence of many conditions and diseases. Yet many clinician training programs neglect to integrate this information across their curricula...
  8. pmc Strategies and methods to study sex differences in cardiovascular structure and function: a guide for basic scientists
    Virginia M Miller
    Departments of Surgery, Physiology and Biomedical Engineering, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA
    Biol Sex Differ 2:14. 2011
    ..abstract:..
  9. pmc Alterations in platelet function and cell-derived microvesicles in recently menopausal women: relationship to metabolic syndrome and atherogenic risk
    Muthuvel Jayachandran
    Department of Physiology and Biomedical Engineering, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    J Cardiovasc Transl Res 4:811-22. 2011
    ..These cellular changes may explain in part how menopause contributes to MS and, eventually, to cardiovascular disease...
  10. pmc Vascular actions of estrogens: functional implications
    Virginia M Miller
    Surgery and Physiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Pharmacol Rev 60:210-41. 2008
    ..Although consensus opinions are emphasized, controversial views are presented to stimulate future research...
  11. ncbi request reprint Introduction to pathologic calcification: crystallization, infection, or cellular transdifferentiation
    Virginia M Miller
    Department of Surgery, Mayo Clinic College of Medicine, Rochester, MN, TX 55905, USA
    J Investig Med 54:365-6. 2006
  12. ncbi request reprint Endothelium-dependent effects of estrogen on vasomotor tone. Consequences of nongenomic actions
    Virginia M Miller
    Department of Surgery, Physiology and Biophysics, Medical Science 4 62, Mayo Clinic and Foundation, 200 First Street Southwest, Rochester, MN 55905, USA
    Vascul Pharmacol 38:109-13. 2002
    ..These results provide proof of principal that estradiol modulates responses of endothelial cells to vasoactive stimuli through changes in regulation of intracellular calcium...
  13. pmc Using basic science to design a clinical trial: baseline characteristics of women enrolled in the Kronos Early Estrogen Prevention Study (KEEPS)
    V M Miller
    Medical Science 4 62, College of Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    J Cardiovasc Transl Res 2:228-39. 2009
    ..KEEPS will provide information relevant to the critical timing hypothesis for MHT use in reducing risk for CVD...
  14. ncbi request reprint Use of BNP and CRP as biomarkers in assessing cardiovascular disease: diagnosis versus risk
    Virginia M Miller
    Departments of Surgery, Physiology and Biomedical Engineering, Mayo Clinic Rochester, Rochester, MN 55905, USA
    Curr Vasc Pharmacol 5:15-25. 2007
    ....
  15. ncbi request reprint Platelet characteristics change with aging: role of estrogen receptor beta
    Muthuvel Jayachandran
    Department of Surgery, Physiology and Biophysics, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905
    J Gerontol A Biol Sci Med Sci 60:815-9. 2005
    ..Therefore, deletion of betaER is associated with specific platelet functions, which are expressed only with age-associated reproductive senescence...
  16. ncbi request reprint Controversy of hormone treatment and cardiovascular function: need for strengthened collaborations between preclinical and clinical scientists
    Virginia M Miller
    Departments of Surgery, Physiology and Biophysics, Mayo Clinic, Rochester, MN 55905, USA
    Curr Opin Investig Drugs 4:1220-32. 2003
    ....
  17. ncbi request reprint Evidence of nanobacterial-like structures in calcified human arteries and cardiac valves
    Virginia M Miller
    Department of Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Physiol Heart Circ Physiol 287:H1115-24. 2004
    ..Therefore, nanometer-scale particles similar to those described as nanobacteria isolated from geological specimens and human kidney stones can be visualized in and cultured from calcified human cardiovascular tissue...
  18. ncbi request reprint Sex steroids and endothelial function: translating basic science to clinical practice
    Virginia M Miller
    Department of Surgery, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Trends Pharmacol Sci 28:263-70. 2007
    ..Therefore, endogenous hormonal status could present a confounding factor in the assessment of endothelial function...
  19. ncbi request reprint Estrogen therapy and thrombotic risk
    Virginia M Miller
    Department of Surgery, Mayo Clinic College of Medicine, Rochester, MN 55905, United States
    Pharmacol Ther 111:792-807. 2006
    ....
  20. doi request reprint Estrogen, inflammation, and platelet phenotype
    Virginia M Miller
    Department of Surgery, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Gend Med 5:S91-S102. 2008
    ..Although exogenous estrogenic therapies increase the risk of thrombosis, the effects of estrogen on formed elements of blood are uncertain...
  21. pmc Biologic nanoparticles and platelet reactivity
    Virginia M Miller
    Department of Surgery, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Nanomedicine (Lond) 4:725-33. 2009
    ..Since platelet aggregation and secretory processes participate in normal hemostasis, thrombosis and vascular remodeling, experiments were designed to determine if these biologic NPs alter specific platelet functions in vitro...
  22. doi request reprint Sex-based differences in vascular function
    V M Miller
    Departments of Surgery and Physiology and Biomedical Engineering, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Womens Health (Lond Engl) 6:737-52. 2010
    ..In this era of personalized medicine, basic research into mechanisms of sex differences in vascular function will result in improved prevention, detection and treatment of cardiovascular disease in both men and women...
  23. ncbi request reprint Time and dose effect of transdermal nicotine on endothelial function
    V M Miller
    Departments of Surgery, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Am J Physiol Heart Circ Physiol 279:H1913-21. 2000
    ..This complex relationship of duration and dose of nicotine treatment may explain, in part, discrepancies in effects of nicotine on endothelium-dependent responses...
  24. ncbi request reprint Prostaglandins but not nitric oxide are endothelium-derived relaxing factors in the trout aorta
    V M Miller
    Departments of Surgery, and Physiology and Biophysics, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Acta Pharmacol Sin 21:871-6. 2000
    ..To identify the type of prostanoids produced by endothelial cells of trout aorta and to determine whether or not the smooth muscle responds to nitric oxide...
  25. ncbi request reprint Pharmacological assessment of adrenergic receptors in human varicose veins
    V M Miller
    Department of Surgery, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Int Angiol 19:176-83. 2000
    ..Experiments were to characterize pharmacologically adrenergic receptors in human varicose veins to the natural transmitter norepinephrine and to an extract of Ruscus...
  26. ncbi request reprint Ageing, oestrogen, platelets and thrombotic risk
    Virginia M Miller
    Department of Surgery, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Clin Exp Pharmacol Physiol 34:814-21. 2007
    ..e. adhesion, aggregation, secretion and thrombin production) in individuals with documented hormonal status are needed to better understand how hormonal changes associated with ageing impact thrombotic risk...
  27. pmc Reporting of sex as a variable in cardiovascular studies using cultured cells
    K Efua Taylor
    Department of Physiology and Biomedical Engineering, Mayo Clinic, 200 1st St SW, Rochester, MN 55905 USA
    Biol Sex Differ 2:11. 2011
    ..abstract:..
  28. ncbi request reprint Gender differences and endothelium- and platelet-derived factors in the coronary circulation
    V M Miller
    Department of Surgery, Mayo Foundation, Rochester, Minnesota 55905, USA
    Clin Exp Pharmacol Physiol 26:132-6. 1999
    ..Furthermore, there are gender differences in platelets in the release of cyclo-oxygenase metabolites of arachidonic acid and 5-HT. These products could contribute to gender differences in response to injury in the coronary circulation...
  29. ncbi request reprint Selected contribution: Effects of sex and ovariectomy on responses to platelets in porcine femoral veins
    D A Lewis
    Department of Surgery, Mayo Clinic and Foundation, 200 First St. SW, Rochester, MN 55905, USA
    J Appl Physiol 91:2823-30. 2001
    ..In addition, products of cyclooxygenase may reduce endothelium-dependent relaxations in veins...
  30. ncbi request reprint Is nitric oxide the only endothelium-derived relaxing factor in canine femoral veins?
    V M Miller
    Department of Physiology and Biophysics, Mayo Clinic, Rochester, Minnesota 55905
    Am J Physiol 257:H1910-6. 1989
    ..A factor dissimilar to nitric oxide but acting like sodium nitroprusside may be released by the endothelium of canine systemic veins...
  31. ncbi request reprint Endothelial function and cardiovascular risk stratification in menopausal women
    S L Mulvagh
    Department of Internal Medicine, Division of Cardiovascular Diseases, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Climacteric 13:45-54. 2010
    ..This study tested the hypothesis that digital tonometry, as a surrogate of endothelial function, is useful to stratify cardiovascular risk in recently menopausal women who are asymptomatic for cardiovascular disease...
  32. ncbi request reprint Acute effects of 17beta -estradiol on femoral veins from adult gonadally intact and ovariectomized female pigs
    M P Bracamonte
    Department of Physiology and Biophysics, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Am J Physiol Heart Circ Physiol 283:H2389-96. 2002
    ..The relative contribution of nitric oxide and K(+) channels as mechanisms involved in relaxations to 17beta-estradiol in femoral veins is modulated by ovarian status...
  33. ncbi request reprint Endothelin-1 modulates intrahepatic resistance in a rat model of noncirrhotic portal hypertension
    P S Kamath
    Department of Medicine, Mayo Clinic, Rochester, MN, USA
    Hepatology 30:401-7. 1999
    ..We conclude that in a BDL model of portal hypertension where distortion of hepatic architecture by fibrosis is minimal, increased resistance to portal blood flow may be mediated by ET-1...
  34. ncbi request reprint Gene transfer of endothelial nitric oxide synthase to pulmonary allografts: impact on acute rejection
    A Jeppsson
    Mayo Clinic and Foundation, Rochester, Minnesota, USA
    Transpl Int 13:S591-6. 2000
    ..eNOS gene transfer to pulmonary allografts results in a functionally active transgene product and increased NO production. Increasing NO from eNOS does not affect histogically identified acute rejection...
  35. ncbi request reprint Effects of dietary L-arginine on structure and function of flow-restricted vein grafts
    M E Landis
    Department of Surgery, Mayo Foundation, Rochester, MN, USA
    J Vasc Surg 33:829-39. 2001
    ..Therefore, dietary supplementation with L -arginine may not improve long-term functions of flow-restricted peripheral bypass grafts...
  36. ncbi request reprint Ovariectomy increases mitogens and platelet-induced proliferation of arterial smooth muscle
    M P Bracamonte
    Department of Physiology and Biophysics, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Am J Physiol Heart Circ Physiol 283:H853-60. 2002
    ..Higher levels of PDGF(BB) in platelets in synergy with other platelet-derived products could contribute to increased proliferative arterial response to injury after ovariectomy...
  37. pmc Comparison of calibrated and uncalibrated bone mineral density by CT to DEXA in menopausal women
    Y Miyabara
    Department of Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Climacteric 15:374-81. 2012
    ....
  38. pmc Circulating microparticles and endogenous estrogen in newly menopausal women
    M Jayachandran
    Department of Surgery, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Climacteric 12:177-84. 2009
    ..A marker of these modulatory activities is formation of cell-specific microparticles. This study examined the relationship between blood-borne microparticles and endogenous estrogen at menopause...
  39. ncbi request reprint Further attenuation of endothelium-dependent relaxation imparted by natriuretic peptide receptor antagonism
    P W Wennberg
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Am J Physiol 277:H1618-21. 1999
    ..These investigations support the concept of release of multiple endothelium-derived factors in response to acetylcholine- and bradykinin-receptor stimulation in endothelial cells, which may include CNP, as well as NO...
  40. ncbi request reprint Gender-related differences in proliferative responses of vascular smooth muscle cells to endothelin-1
    D Antoniucci
    Department of Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Endothelium 8:137-45. 2001
    ..Gender associated inhibition of smooth muscle proliferation by endothelin-1 may contribute, in part, to cardioprotection noted in estrogen-replete states...
  41. ncbi request reprint Differential effects of 17beta-estradiol, conjugated equine estrogen, and raloxifene on mRNA expression, aggregation, and secretion in platelets
    Muthuvel Jayachandran
    Department of Physiology and Bioengineering, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Am J Physiol Heart Circ Physiol 288:H2355-62. 2005
    ..These differences reflect transcriptional and posttranscriptional regulation of protein synthesis in bone marrow megakaryocytes and circulating platelets...
  42. ncbi request reprint In vivo effects of lipopolysaccharide and TLR4 on platelet production and activity: implications for thrombotic risk
    Muthuvel Jayachandran
    Department of Surgery, Mayo Clinic Rochester, 200 First St SW, Rochester, MN 55905, USA
    J Appl Physiol (1985) 102:429-33. 2007
    ..The persistence of the effect 1 wk after the injection suggests that the changes reflect an action of LPS on megakaryocytes and their platelet progeny rather than on circulating platelets, which would have been cleared...
  43. ncbi request reprint Vascular effects of estrogens: arterial protection versus venous thrombotic risk
    M P Bracamonte
    Dept of Physiology and Biophysics, Mayo Clinic, 55905, Rochester, MN, USA
    Trends Endocrinol Metab 12:204-9. 2001
    ....
  44. ncbi request reprint Cofactors of constitutive nitric oxide synthase and endothelium-dependent relaxations in canine femoral veins
    D A Lewis
    Department of Surgery, Mayo Clinic and Foundation, Rochester, Minnesota 55905
    J Cardiovasc Pharmacol 22:443-8. 1993
    ..These data suggest that endothelium-dependent relaxations in canine femoral veins are mediated by factor(s) that are partly dependent on calmodulin or NADPH as cofactors for their production or release...
  45. ncbi request reprint Prospective randomized study of effects of unopposed estrogen replacement therapy on markers of coagulation and inflammation in postmenopausal women
    M D Luyer
    Department of Surgery, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 86:3629-34. 2001
    ..Concomitant changes in these parameters may reduce the risk for arterial disease while altering the threshold for thrombotic events...
  46. ncbi request reprint Increased coronary effects of stimulation of endothelin-B receptor in experimental hypercholesterolemia
    V Mathew
    Department of Internal Medicine, Mayo Foundation, Rochester, Minnesota, USA
    Coron Artery Dis 11:585-92. 2000
    ..Experimental hypercholesterolemia is associated with an increase in coronary vasoconstrictor response to endothelin-1 in vivo, although the relative contributions of subtypes of endothelin receptor in this model remain unknown...
  47. pmc Aggregation and microparticle production through toll-like receptor 4 activation in platelets from recently menopausal women
    Kazunori Hashimoto
    Department of Surgery, College of Medicine, MayoClinic, Rochester, MN 55905, USA
    J Cardiovasc Pharmacol 54:57-62. 2009
    ....
  48. ncbi request reprint Evaluation of a xenogeneic acellular collagen matrix as a small-diameter vascular graft in dogs--preliminary observations
    S Nemcova
    Department of Surgery, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Invest Surg 14:321-30. 2001
    ..This preliminary study demonstrates that a collagen-based xenogeneic biomaterial provides a scaffold for cellularization when used for arterial reconstruction in dogs...
  49. pmc Systemic injection of planktonic forms of mammalian-derived nanoparticles alters arterial response to injury in rabbits
    Maria K Schwartz
    Department of Physiology and Biomedical Engineering, Medical Sciences 4 62, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Am J Physiol Heart Circ Physiol 296:H1434-41. 2009
    ..In conclusion, the systemic administration of planktonic forms of human-derived NPs exacerbated arterial response to injury distinct from that of bovine-derived NPs and other inflammatory agents...
  50. ncbi request reprint Sex-specific changes in platelet aggregation and secretion with sexual maturity in pigs
    Muthuvel Jayachandran
    Dept of Surgery, Mayo Clinic Rochester, 200 First St SW, Rochester, MN 55905, USA
    J Appl Physiol 97:1445-52. 2004
    ..These observations provide evidence on which clinical studies could be designed to examine platelet characteristics in human children and young adults...
  51. ncbi request reprint Estrogenic regulation of tissue factor and tissue factor pathway inhibitor in platelets
    Muthuvel Jayachandran
    Dept of Surgery, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Am J Physiol Heart Circ Physiol 289:H1908-16. 2005
    ..These studies provide the rationale for evaluation of interactions among platelets and TF and TFPI expression on thrombin generation during estrogen treatment in humans...
  52. ncbi request reprint Effects of ovariectomy on aggregation, secretion, and metalloproteinases in porcine platelets
    Muthuvel Jayachandran
    Department of Surgery, Mayo Clinic Rochester, 200 First Street SW, Rochester, MN 55905, USA
    Am J Physiol Heart Circ Physiol 284:H1679-85. 2003
    ..Increased platelet aggregation and activity of MMP-2 would alter platelet-platelet and platelet-vessel wall interactions, contributing to an exaggerated response to injury with loss of ovarian hormones...
  53. pmc Loss of estrogen receptor beta decreases mitochondrial energetic potential and increases thrombogenicity of platelets in aged female mice
    Muthuvel Jayachandran
    Department of Surgery, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN, 55905, USA
    Age (Dordr) 32:109-21. 2010
    ....
  54. pmc Characterization of blood borne microparticles as markers of premature coronary calcification in newly menopausal women
    Muthuvel Jayachandran
    Department of Surgery and Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 1st St SW, Rochester, MN 55905, USA
    Am J Physiol Heart Circ Physiol 295:H931-H938. 2008
    ..Therefore, the characterization of platelet and endothelial microparticles may identify early menopausal women with premature CAC who would not otherwise be identified by the usual risk factor analysis...
  55. ncbi request reprint Hepatic localization of endothelin-1 in patients with idiopathic portal hypertension and cirrhosis of the liver
    P S Kamath
    Departments of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Liver Transpl 6:596-602. 2000
    ..In late stages of cirrhosis, ET-1 may not modulate resistance. We speculate that vascular resistance in late stages of cirrhosis probably results from distortion of hepatic architecture...
  56. doi request reprint Coronary arterial calcification and thoracic spine mineral density in early menopause
    Y Miyabara
    Department of Surgery, Mayo Clinic, 200 First St SW Rochester, MN 55905, USA
    Climacteric 14:438-44. 2011
    ....
  57. pmc Sex, hormones and neuroeffector mechanisms
    E C Hart
    Department of Anesthesia, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Acta Physiol (Oxf) 203:155-65. 2011
    ..Studies are needed to further evaluate how hormonal treatments and drugs used to modulate adrenergic and serotonergic activity affect progression and risk for cardiovascular disease in men and women...
  58. ncbi request reprint Endothelium-dependent responses and their potential relevance to the distribution of blood flow during hemorrhagic shock
    V M Miller
    Department of Physiology and Biophysics, Mayo Clinic, Rochester, MN 55905
    Resuscitation 18:165-71. 1989
    ....
  59. ncbi request reprint Endothelium-dependent responses in coronary arteries are changed with puberty in male pigs
    Ritu Chatrath
    Division of Pediatric Cardiology, Department of Surgery, Mayo Clinic Rochester, 200 First Street S W, Rochester, MN 55905, USA
    Am J Physiol Heart Circ Physiol 285:H1168-76. 2003
    ..In addition, endothelium-derived inhibitory cyclooxygenase products seem to predominate in juveniles...
  60. ncbi request reprint Ovariectomy upregulates expression of estrogen receptors, NOS, and HSPs in porcine platelets
    Muthuvel Jayachandran
    Department of Surgery and Physiology and Biophysics, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Am J Physiol Heart Circ Physiol 283:H220-6. 2002
    ..These results suggest that ovarian hormones influence expression of estrogen receptors and eNOS in platelets. Changes in estrogen receptors and NOS could affect platelet aggregation in response to hormone replacement...
  61. ncbi request reprint Differential effects of chronic treatment with estrogen receptor ligands on regulation of nitric oxide synthase in porcine aortic endothelial cells
    Hiroya Okano
    Department of Surgery, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Cardiovasc Pharmacol 47:621-8. 2006
    ..Three clinically relevant estrogen treatments restore plasma NO after ovariectomy, but do not affect eNOS mRNA, posttranslational regulation of eNOS or expression of estrogen receptors in the same way...
  62. ncbi request reprint Induction and cDNA sequence of inducible nitric oxide synthase from canine aortic smooth muscle cells
    X Wang
    Division of Cardiothoracic Surgery, Departments of Surgery and Physiology and Biophysics, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Am J Physiol 275:H1122-9. 1998
    ....
  63. ncbi request reprint Do calcifying nanoparticles promote nephrolithiasis? A review of the evidence
    F A Shiekh
    Departments of Internal Medicine, Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA
    Clin Nephrol 71:1-8. 2009
    ..This review evaluates the current evidence regarding nanoparticles as causal to disease and emphasizes the need for additional research to further elucidate their role in human stone formation...
  64. ncbi request reprint Human platelets contain estrogen receptor alpha, caveolin-1 and estrogen receptor associated proteins
    Muthuvel Jayachandran
    Department of Surgery, Mayo Clinic Rochester, 200 First Street SW, Rochester, MN 55905, USA
    Platelets 14:75-81. 2003
    ....
  65. pmc Sex/gender medicine. The biological basis for personalized care in cardiovascular medicine
    Faisal A Arain
    Department of General Internal Medicine, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Circ J 73:1774-82. 2009
    ....
  66. ncbi request reprint Mechanism of raloxifene-induced relaxation in femoral veins depends on ovarian hormonal status
    Margarita P Bracamonte
    Department of Physiology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Cardiovasc Pharmacol 39:704-13. 2002
    ..Whether nitric oxide or potassium channel activation contributes to relaxations by raloxifene may depend on ovarian hormonal status of the animal...
  67. ncbi request reprint Treatment with raloxifene and 17beta-estradiol differentially modulates nitric oxide and prostanoids in venous endothelium and platelets of ovariectomized pigs
    Debra A Lewis
    Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Cardiovasc Pharmacol 48:231-8. 2006
    ..These differences, if found in humans, may contribute to varying degrees of thrombotic risk with the SERM compared to the natural hormone...
  68. ncbi request reprint Correlating androgen and estrogen steroid receptor expression with coronary calcification and atherosclerosis in men without known coronary artery disease
    Peter Y Liu
    Division of Endocrinology, Metabolism, Diabetes and Nutrition, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 90:1041-6. 2005
    ..We therefore examined AR, ER alpha, and ER beta expression as a function of key components of atherosclerosis, namely plaque and calcium area, in male human coronary arteries...
  69. ncbi request reprint Pilot study of sex differences in chemokine/cytokine markers of atherosclerosis in humans
    Joseph Leung
    Department of Surgery, Physiology, and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Gend Med 5:44-52. 2008
    ....
  70. ncbi request reprint Differential effects of 17beta-estradiol and raloxifene on VSMC phenotype and expression of osteoblast-associated proteins
    Ewa Rzewuska-Lech
    Department of Surgery, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Am J Physiol Endocrinol Metab 289:E105-12. 2005
    ..In conclusion, E(2) slows differentiation of VSMC induced by excess phosphate. Effectiveness of raloxifene to preserve expression of bone cell-associated proteins depends on the hormonal status of the tissue donor...
  71. ncbi request reprint The effects of CTLA-4Ig on acute lung allograft rejection: a comparison of intrabronchial gene therapy with systemic administration of protein
    M M Ugurlu
    Department of Surgery, Mayo Transplant Center, Mayo Clinic, Rochester, MN 55905
    Transplantation 71:1867-71. 2001
    ..CONCLUSION: Local expression of immunomodulatory proteins can be achieved within lung allografts by intrabronchial delivery of adenoviral vector but may not significantly modify acute rejection...
  72. ncbi request reprint Effect of puberty on coronary arteries from female pigs
    Ritu Chatrath
    Division Pediatric Cardiology, Mayo Clinic Rochester, 200 First St SW, Rochester, MN 55905, USA
    J Appl Physiol 95:1672-80. 2003
    ..At maturity, plasma NO is reduced and sensitivity of the smooth muscle to exogenous NO is increased. Posttranscriptional regulation of eNOS protein may explain differences in NO bioavailability in juvenile pigs...
  73. ncbi request reprint Endothelial function in pigs transgenic for human complement regulating factor
    Gregor Warnecke
    Division of Cardiothoracic Surgery and Transplantation, Department of Surgery, Mayo Clinic and Foundation, 200 First Street SW, Rochester MN 55905, USA
    Transplantation 73:1060-7. 2002
    ..Experiments were designed to characterize endothelial and smooth muscle function of arteries from pigs transgenic for hCD46...
  74. pmc Characterization of biofilm formed by human-derived nanoparticles
    Maria K Schwartz
    Department of Physiology and Biomedical Engineering, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Nanomedicine (Lond) 4:931-41. 2009
    ..Experiments were designed to identify infectious pathogens in human aneurysms and to characterize biofilm formed by calcified human arterial-derived nanoparticles...
  75. ncbi request reprint Cell biology of pathologic renal calcification: contribution of crystal transcytosis, cell-mediated calcification, and nanoparticles
    Vivek Kumar
    Division of Nephrology, Mayo Clinic College of Medicine, Rochester, MN, USA
    J Investig Med 54:412-24. 2006
    ..The earliest lesion in the kidneys of idiopathic calcium oxalate stone formers is deposition of calcium phosphate in the interstitium, termed a Randall's plaque. Yet the cellular and molecular factors leading to their formation are unknown...
  76. ncbi request reprint Pulmonary arterial reactivity during induced infection of single lung allografts
    Hae Kyoon Kim
    Mayo Clinic College of Medicine, Rochester, MN 55905, United States
    Eur J Cardiothorac Surg 31:475-81. 2007
    ..Such information could help to develop better diagnostic and therapeutic targets to improve outcome when grafts become infected...
  77. ncbi request reprint Women, hormones, and clinical trials: a beginning, not an end
    Virginia M Miller
    J Appl Physiol 99:381-3. 2005
  78. ncbi request reprint Intimal estrogen receptor (ER)beta, but not ERalpha expression, is correlated with coronary calcification and atherosclerosis in pre- and postmenopausal women
    Rose C Christian
    Amgen, Inc, One Amgen Center Drive, Thousand Oaks, California 91361, USA
    J Clin Endocrinol Metab 91:2713-20. 2006
    ..In this study, we examined coronary artery ERalpha and ERbeta expression in pre- and postmenopausal women as a function of plaque area, calcium area, calcium-to-plaque ratio, and estrogen status...
  79. ncbi request reprint Of mice, men, and hormones
    Virginia M Miller
    Arterioscler Thromb Vasc Biol 24:995-7. 2004
  80. ncbi request reprint Postmenopausal hormone therapy: new questions and the case for new clinical trials
    JoAnn E Manson
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Menopause 13:139-47. 2006
    ....
  81. ncbi request reprint Search for microbial signatures within human and microbial calcifications using soft x-ray spectromicroscopy
    Karim Benzerara
    Institut de Minéralogie et de Physique des Milieux Condensés, UMR 7590 and Institut de Physique du Glove de Paris, Paris Cedex, France
    J Investig Med 54:367-79. 2006
    ..To address this controversy, the use of techniques capable of characterizing the organic and mineral content of these self-replicated structures at the submicrometer scale would be beneficial...
  82. ncbi request reprint Advancing the study of stroke in women: summary and recommendations for future research from an NINDS-Sponsored Multidisciplinary Working Group
    Cheryl D Bushnell
    Department of Medicine, Division of Neurology, Duke University Medical Center, Durham, NC 27710, USA
    Stroke 37:2387-99. 2006
    ..Besides the role of estrogen there are many gaps of knowledge about issues specific to women and stroke...
  83. ncbi request reprint Sex-based physiology prior to political correctness
    Virginia M Miller
    Am J Physiol Endocrinol Metab 289:E359-60. 2005
  84. ncbi request reprint Mechanisms of estrogenic vascular protection
    Muthuvel Jayachandran
    Am J Physiol Heart Circ Physiol 290:H507-8. 2006

Research Grants12

  1. Estrogen, Platelets, and Artherosclerosis
    VIRGINIA MILLER; Fiscal Year: 2009
    ..Thus, results will identify which women could benefit most with the least harm from hormone use in early menopause. ..
  2. ESTROGEN STATUS AND THE FUNCTION OF CORONARY ARTERIES
    VIRGINIA MILLER; Fiscal Year: 2002
    ..The experiments of this proposal take such an approach using molecular to integrated whole animal physiology. ..
  3. ESTROGEN STATUS AND THE FUNCTION OF CORONARY ARTERIES
    VIRGINIA MILLER; Fiscal Year: 2001
    ..The experiments of this proposal take such an approach using molecular to integrated whole animal physiology. ..
  4. ESTROGEN STATUS AND THE FUNCTION OF CORONARY ARTERIES
    VIRGINIA MILLER; Fiscal Year: 1999
    ..The experiments of this proposal take such an approach using molecular to integrated whole animal physiology. ..
  5. ESTROGEN STATUS AND THE FUNCTION OF CORONARY ARTERIES
    VIRGINIA MILLER; Fiscal Year: 2000
    ..The experiments of this proposal take such an approach using molecular to integrated whole animal physiology. ..
  6. Estrogen, Platelets, and Artherosclerosis
    Whyte G Owen; Fiscal Year: 2010
    ..Thus, results will identify which women could benefit most with the least harm from hormone use in early menopause. ..