Research Topics
Genomes and GenesSpecies | J M MilesSummaryAffiliation: Mayo Clinic Country: USA Publications
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Publications
Intravenous niacin acutely improves the efficiency of dietary fat storage in lean and obese humansRobert H Nelson
Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota, USA
Diabetes 61:3172-5. 2012..Infusion of intravenous niacin provides a model for acutely improving dietary fat storage, perhaps by suppressing lipolysis in visceral adipose tissue...- Effect of insulin infusion on spillover of meal-derived fatty acidsKalpana Muthusamy
Endocrine Research Unit, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
J Clin Endocrinol Metab 97:4201-5. 2012..Spillover of chylomicron triglyceride fatty acids directly into the circulation as free fatty acids (FFAs) during lipoprotein lipase hydrolysis may contribute to the elevated total FFAs seen in insulin-resistant states... 
Effect of orlistat in overweight and obese patients with type 2 diabetes treated with metforminJohn M Miles
Lipid and Diabetes Research Center, St Lukes Hospital, Kansas City, Missouri, USA
Diabetes Care 25:1123-8. 2002..The purpose of this study was to assess the effect of orlistat, a gastrointestinal lipase inhibitor, on body weight, glycemic control, and cardiovascular risk factors in metformin-treated type 2 diabetic patients...- Systemic and forearm triglyceride metabolism: fate of lipoprotein lipase-generated glycerol and free fatty acidsJohn M Miles
Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota, USA
Diabetes 53:521-7. 2004..They further suggest that LPL-mediated fatty acid uptake is an inefficient process, but may be more efficient in muscle than in adipose tissue... - Energy expenditure in hospitalized patients: implications for nutritional supportJohn M Miles
Endocrine Research Unit, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
Mayo Clin Proc 81:809-16. 2006..Additional research in hospitalized patients on total energy expenditure and on the relationship between severity of illness and energy expenditure is needed... - Nocturnal and postprandial free fatty acid kinetics in normal and type 2 diabetic subjects: effects of insulin sensitization therapyJohn M Miles
Mid America Heart Institute of Saint Luke s Hospital, University of Missouri Kansas City, Kansas City, MO, USA
Diabetes 52:675-81. 2003..In summary, nocturnal and postprandial FFA R(a) is increased in type 2 diabetes. Postprandial lipolysis appears to be preferentially improved by thiazolidinediones compared with nocturnal lipolysis... - A role for the glycemic index in preventing or treating diabetes?John M Miles
Division of Endocrinology, Metabolism and Nutrition, Mayo Clinic, Rochester, MN 55905, USA
Am J Clin Nutr 87:1-2. 2008 - Contribution of triglyceride-rich lipoproteins to plasma free fatty acidsJ M Miles
Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA
Horm Metab Res 39:726-9. 2007..If systemic spillover is increased in insulin resistant states such as diabetes, this could represent a mechanism contributing to the abnormal increases in plasma concentrations of free fatty acids in that condition... - No, the glycaemic target in the critically ill should not be < or = 6.1 mmol/lJ M Miles
Endocrine Research Unit, Mayo Clinic, Rochester, MN, USA
Diabetologia 51:916-20. 2008 - Counterpoint: visceral adiposity is not causally related to insulin resistanceJohn M Miles
Endocrine Research Unit, Division of Endocrinology, Metabolism and Nutrition, Mayo Clinic, Rochester, Minnesota 55905, USA
Diabetes Care 28:2326-8. 2005 - Triacetin: a potential parenteral nutrientJ W Bailey
Department of Medicine, Mayo Medical School, Rochester, Minnesota 55905
JPEN J Parenter Enteral Nutr 15:32-6. 1991..These preliminary data indicate that triacetin may have a future role as a parenteral nutrient, and that further studies of its use are warranted... - Estrogen supplementation selectively enhances hypothalamo-pituitary sensitivity to ghrelin in postmenopausal womenPetra Kok
Department of Internal Medicine, Mayo School of Graduate Medical Education, Clinical Translational Science Center, Mayo Clinic, Rochester, Minnesota 55905, USA
J Clin Endocrinol Metab 93:4020-6. 2008..The hypothesis is relevant to understanding the basis of hyposomatotropism in aging and other relatively hypogonadal states... - Pituitary and/or peripheral estrogen-receptor alpha regulates follicle-stimulating hormone secretion, whereas central estrogenic pathways direct growth hormone and prolactin secretion in postmenopausal womenMihaela Cosma
Endocrine Research Unit, Department of Internal Medicine, Mayo Medical and Graduate Schools of Medicine, Mayo Clinic, 200 First Street S W, Rochester, Minnesota 55905, USA
J Clin Endocrinol Metab 93:951-8. 2008..Estradiol (E(2)) stimulates GH and prolactin secretion and suppresses FSH secretion in postmenopausal women. Whether central nervous system (CNS) or pituitary mechanisms (or both) mediate such actions is not known... - Calcium, magnesium, and phosphorus metabolism in dogs given intravenous triacetinJ W Bailey
Endocrine Research Unit, Mayo Clinic and Medical School, Rochester, MN 55905
Am J Clin Nutr 49:385-8. 1989..A short-chain triglyceride administered to dogs at a rate approximating resting energy expenditure has no demonstrable adverse effects on mineral metabolism... - Pre- versus postmenopausal age, estradiol, and peptide-secretagogue type determine pulsatile growth hormone secretion in healthy women: studies using submaximal agonist drive and an estrogen clampSusan B Hudson
Department of Obstetrics and Gynecology, Mayo School of Graduate Medical Education, Clinical Translational Research Center, Mayo Clinic, Rochester, Minnesota 55905
J Clin Endocrinol Metab 95:353-60. 2010..GH-releasing peptide (GHRP), GHRH, and somatostatin are physiological regulators of pulsatile GH secretion... - Dual secretagogue drive of burst-like growth hormone secretion in postmenopausal compared with premenopausal women studied under an experimental estradiol clampDana Erickson
Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Medical and Graduate Schools of Medicine, General Clinical Research Center, Mayo Clinic, Rochester, Minnesota 55905, USA
J Clin Endocrinol Metab 89:4746-54. 2004.... - Gonadal status and body mass index jointly determine growth hormone (GH)-releasing hormone/GH-releasing peptide synergy in healthy menRemberto C Paulo
Department of Pediatrics, Endocrine Research Unit, Clinical Translational Research Center, Mayo Medical and Graduate Schools, Mayo Clinic, Rochester, Minnesota 55901, USA
J Clin Endocrinol Metab 93:944-50. 2008..The issue is important in designing GH-stimulation regimens that are relatively insensitive to both gonadal status and adiposity... - Splanchnic spillover of extracellular lipase-generated fatty acids in overweight and obese humansRobert H Nelson
Endocrine Research Unit, Division of Endocrinology, Metabolism, Diabetes and Nutrition, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
Diabetes 56:2878-84. 2007..The present study was undertaken to determine whether spillover occurs in the splanchnic bed of humans... - Estradiol supplementation in postmenopausal women attenuates suppression of pulsatile growth hormone secretion by recombinant human insulin-like growth factor type IJohannes D Veldhuis
Department of Medicine, Mayo School of Graduate Medical Education, Clinical Translational Science Center, Mayo Clinic, Rochester, Minnesota 55905, USA
J Clin Endocrinol Metab 93:4471-8. 2008..One possibility is that estrogen not only enhances stimulation by secretagogues but also attenuates negative feedback by systemic IGF-I. SITE: The study took place at an academic medical center... - Testosterone supplementation in older men restrains insulin-like growth factor's dose-dependent feedback inhibition of pulsatile growth hormone secretionJohannes D Veldhuis
Department of Medicine, Endocrine Research Unit, Mayo School of Graduate Medical Education, Clinical Translational Science Center, Mayo Clinic, Rochester, Minnesota 55905, USA
J Clin Endocrinol Metab 94:246-54. 2009..The causal mechanisms are unknown. Candidates include deficient feedforward (stimulation) by endogenous secretagogues and excessive feedback (inhibition) by GH or IGF-I due to age and/or relative hypoandrogenemia... - Ghrelin potentiates growth hormone secretion driven by putative somatostatin withdrawal and resists inhibition by human corticotropin-releasing hormoneJohannes D Veldhuis
Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Medical and Graduate Schools of Medicine, General Clinical Research Center, Mayo Clinic, Rochester, Minnesota 55905, USA
J Clin Endocrinol Metab 91:2441-6. 2006..Beyond the capability of ghrelin to synergize with GHRH, little is known about multipeptide modulation of ghrelin's actions in humans... - Novel relationships of age, visceral adiposity, insulin-like growth factor (IGF)-I and IGF binding protein concentrations to growth hormone (GH) releasing-hormone and GH releasing-peptide efficacies in men during experimental hypogonadal clampJohannes D Veldhuis
Endocrine Research Unit, Mayo School of Graduate Medical Education, Clinical Translational Science Center, Mayo Clinic, Rochester, Minnesota 55905, USA
J Clin Endocrinol Metab 94:2137-43. 2009..Sex steroids influence GH secretion in complex ways... - Preservation of GHRH and GH-releasing peptide-2 efficacy in young men with experimentally induced hypogonadismJohannes D Veldhuis
Endocrine Research Unit, Mayo School of Graduate Medical Education, Clinical Translational Science Center, Mayo Clinic, Rochester, Minnesota 55905, USA
Eur J Endocrinol 161:293-300. 2009..Somatostatin (SS), GHRH, GH-releasing peptide (GHRP), and the sex-steroid milieu regulate GH secretion... - Estradiol potentiates ghrelin-stimulated pulsatile growth hormone secretion in postmenopausal womenJohannes D Veldhuis
Endocrine Research Unit, Department of Internal Medicine, Mayo School of Graduate Medical Education, General Clinical Research Center, Mayo Clinic, Rochester, Minnesota 55905, USA
J Clin Endocrinol Metab 91:3559-65. 2006..Ghrelin and an estrogen-rich milieu individually amplify pulsatile GH secretion by increasing the amount of hormone released per burst. However, how these distinct agonists interact in controlling pulsatile GH output is not known... - Aromatase and 5alpha-reductase inhibition during an exogenous testosterone clamp unveils selective sex steroid modulation of somatostatin and growth hormone secretagogue actions in healthy older menJohannes D Veldhuis
Department of Internal Medicine and Pediatrics, Endocrine Research Unit, Clinical Translational Research Center, Mayo Medical and Graduate Schools, Mayo Clinic, Rochester Minnesota 55901, USA
J Clin Endocrinol Metab 94:973-81. 2009..How endogenous testosterone (Te), 5alpha-dihydrotestosterone (DHT), and estradiol (E(2)) regulate pulsatile GH secretion is not understood... - Sex-steroid control of the aging somatotropic axisJohannes D Veldhuis
Endocrine Research Unit, Department of Internal Medicine, Mayo School of Graduate Medical Education, General Clinical Research Center, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Endocrinol Metab Clin North Am 34:877-93, viii. 2005 - The effect of high-dose simvastatin on triglyceride-rich lipoprotein metabolism in patients with type 2 diabetes mellitusWilliam L Isley
Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic College of Medicine, Rochester, MN, USA
J Lipid Res 47:193-200. 2006..The effect of high-dose simvastatin on triglyceride-rich lipoprotein metabolism in patients with type 2 diabetes mellitus... - Glycemic control and nutrition in the intensive care unitM Molly McMahon
Division of Endocrinology, Diabetes, Metabolism, Nutrition and Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Curr Opin Clin Nutr Metab Care 9:120-3. 2006..Hospital clinicians frequently encounter hyperglycemia due to diabetes or the stress of critical illness in patients who are receiving nutrition support... - Testosterone supplementation in healthy older men drives GH and IGF-I secretion without potentiating peptidyl secretagogue efficacyJohannes D Veldhuis
Department of Internal Medicine, Mayo Medical and Graduate Schools of Medicine, General Clinical Research Center, Mayo Clinic, Rochester, MN 55905, USA
Eur J Endocrinol 153:577-86. 2005..e. reduces opposition by hypothalamic somatostatin) and (iii) abdominal visceral fat (AVF) mass is a negative determinant of specific secretagogue-stimulated GH secretion... - The effect of high-dose simvastatin on free fatty acid metabolism in patients with type 2 diabetes mellitusWilliam L Isley
Endocrine Research Unit, Division of Endocrinology, Nutrition, and Metabolism, Mayo Clinic, Rochester, MN 55905, USA
Metabolism 55:758-62. 2006..These results suggest that the triglyceride-lowering effect of statins is not mediated through an effect on FFA metabolism... - Complementary secretagogue pairs unmask prominent gender-related contrasts in mechanisms of growth hormone pulse renewal in young adultsCacia Soares-Welch
Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo School of Graduate Medical Education, General Clinical Research Center, Mayo Clinic, Rochester, Minnesota 55905, USA
J Clin Endocrinol Metab 90:2225-32. 2005..This inference upholds recent clinical precedence and yields valid predictions of sex differences in self-renewable GH pulsatility... - Effect of parenteral administration of short-chain triglycerides on leucine metabolismJ W Bailey
Department of Medicine, Mayo Clinic and Foundation, Rochester, MN 55905
Am J Clin Nutr 58:912-6. 1993..Because of its water solubility, lack of toxicity, and favorable effects on protein metabolism, further studies are warranted regarding the use of triacetin as a parenteral nutrient... - Insulin in the early management of diabetic complicationsJohn M Miles
Mayo Medical School, Rochester, Minnesota, USA
J Assoc Physicians India 51:501-5. 2003..Insulin therapy has favorable effects on endothelial function and lipids, especially compared with sulfonylureas. More information is needed on the effects of diabetes pharmacotherapy on cardiovascular outcomes... - Triglyceride uptake and lipoprotein lipase-generated fatty acid spillover in the splanchnic bed of dogsRobert H Nelson
Endocrine Research Unit, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
Diabetes 56:1850-5. 2007..005), the latter representing calculation of spillover between arterial and hepatic venous blood without portal venous data. Metabolism of chylomicron triglycerides in visceral fat may be an important source of portal venous FFAs... - The use of orlistat in the treatment of obesity, dyslipidaemia and Type 2 diabetesRobert H Nelson
Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA
Expert Opin Pharmacother 6:2483-91. 2005..Orlistat should only be prescribed for individuals who are motivated to adhere to lifestyle modifications, especially dietary fat restriction... - A new method for the study of chylomicron kinetics in vivoY Park
Department of Medicine, University of Missouri Kansas City, St Luke s Hospital, Kansas City, Missouri 64111, USA
Am J Physiol Endocrinol Metab 279:E1258-63. 2000..kg(-1). h(-1), equal to the presumed ingestion rate. In summary, a radiolabeled intravenous lipid emulsion is able to accurately estimate chylomicron TG R(a) and therefore can be used to measure in vivo fat absorption rates... 
Can serum beta-hydroxybutyrate be used to diagnose diabetic ketoacidosis?Mae Sheikh-Ali
Division of Endocrinology, Diabetes, Nutrition, and Metabolism, Mayo Clinic, Rochester, Minnesota 55905, USA
Diabetes Care 31:643-7. 2008..The present study was undertaken to determine whether quantitative measurement of a ketone body anion could be used to diagnose DKA...- Measurement of human chylomicron triglyceride clearance with a labeled commercial lipid emulsionY Park
University of Missouri Kansas City, Department of Medicine and Cardiovascular Research Department, Mid America Heart Institute, Saint Luke s Hospital, 64111, USA
Lipids 36:115-20. 2001..The results indicate that a radiolabeled commercial lipid emulsion is metabolized in a fashion similar to native chylomicron TG, and thus can be used to study chylomicron TG kinetics... - Bilateral carotid body paragangliomaNicholas W W Choong
Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
Mayo Clin Proc 79:681. 2004 - Myocardial uptake of circulating triglycerides in nondiabetic patients with heart diseaseRobert H Nelson
Endocrine Research Unit, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Diabetes 56:527-30. 2007..5%). These results indicate that circulating triglycerides may be a significant source of fatty acids for myocardial respiration... - A multicompartmental model of in vivo adipose tissue glycerol kinetics and capillary permeability in lean and obese humansSimon W Coppack
Diabetes and Metabolic Medicine, St Bartholomew s and The London School of Medicine, London, UK
Diabetes 54:1934-41. 2005..45, P < 0.05). Our results support previous estimates of interstitial glycerol concentration within adipose tissue and reveal capillary diffusion capacity is reduced in obesity... - What does the measurement of whole-body fatty acid rate of appearance in plasma by using a fatty acid tracer really mean?Bettina Mittendorfer
Department of Internal Medicine and Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri 63110, USA
Diabetes 52:1641-8. 2003.... - Nutritional support in stroke: a balanced meal or a feast?John M Miles
Neurocrit Care 1:283-5. 2004
Research Grants
- FFA Production From Triglyceride-Rich LipoproteinsJohn Miles; Fiscal Year: 2006..These studies will provide new insights into the regulation of FFA metabolism in humans. ..
- FFA Production From Triglyceride-Rich LipoproteinsJohn Miles; Fiscal Year: 2009..Dietary fat may contribute to FFAs by a process known as "spillover", which occurs during fat storage. This work is a comprehensive evaluation of the importance of spillover as a contributor to FFAs. ..
- FFA Production From Triglyceride-Rich LipoproteinsJohn M Miles; Fiscal Year: 2010..Dietary fat may contribute to FFAs by a process known as "spillover", which occurs during fat storage. This work is a comprehensive evaluation of the importance of spillover as a contributor to FFAs. ..