J M Miles

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. doi Use of metformin in diseases of aging
    John M Miles
    Divisions of Endocrinology, Nephrology and Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA
    Curr Diab Rep 14:490. 2014
  2. pmc Intravenous niacin acutely improves the efficiency of dietary fat storage in lean and obese humans
    Robert H Nelson
    Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota, USA
    Diabetes 61:3172-5. 2012
  3. pmc Effect of insulin infusion on spillover of meal-derived fatty acids
    Kalpana Muthusamy
    Endocrine Research Unit, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 97:4201-5. 2012
  4. ncbi Effect of orlistat in overweight and obese patients with type 2 diabetes treated with metformin
    John M Miles
    Lipid and Diabetes Research Center, St Lukes Hospital, Kansas City, Missouri, USA
    Diabetes Care 25:1123-8. 2002
  5. ncbi Contribution of triglyceride-rich lipoproteins to plasma free fatty acids
    J M Miles
    Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    Horm Metab Res 39:726-9. 2007
  6. ncbi No, the glycaemic target in the critically ill should not be < or = 6.1 mmol/l
    J M Miles
    Endocrine Research Unit, Mayo Clinic, Rochester, MN, USA
    Diabetologia 51:916-20. 2008
  7. ncbi A role for the glycemic index in preventing or treating diabetes?
    John M Miles
    Division of Endocrinology, Metabolism and Nutrition, Mayo Clinic, Rochester, MN 55905, USA
    Am J Clin Nutr 87:1-2. 2008
  8. ncbi Counterpoint: visceral adiposity is not causally related to insulin resistance
    John M Miles
    Endocrine Research Unit, Division of Endocrinology, Metabolism and Nutrition, Mayo Clinic, Rochester, Minnesota 55905, USA
    Diabetes Care 28:2326-8. 2005
  9. ncbi Energy expenditure in hospitalized patients: implications for nutritional support
    John M Miles
    Endocrine Research Unit, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Mayo Clin Proc 81:809-16. 2006
  10. ncbi Systemic and forearm triglyceride metabolism: fate of lipoprotein lipase-generated glycerol and free fatty acids
    John M Miles
    Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota, USA
    Diabetes 53:521-7. 2004

Research Grants

Detail Information

Publications44

  1. doi Use of metformin in diseases of aging
    John M Miles
    Divisions of Endocrinology, Nephrology and Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA
    Curr Diab Rep 14:490. 2014
    ..Prospective, randomized trials of the use of metformin in HF are needed to investigate this possibility. ..
  2. pmc Intravenous niacin acutely improves the efficiency of dietary fat storage in lean and obese humans
    Robert H Nelson
    Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota, USA
    Diabetes 61:3172-5. 2012
    ..Infusion of intravenous niacin provides a model for acutely improving dietary fat storage, perhaps by suppressing lipolysis in visceral adipose tissue...
  3. pmc Effect of insulin infusion on spillover of meal-derived fatty acids
    Kalpana Muthusamy
    Endocrine Research Unit, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 97:4201-5. 2012
    ..Spillover of chylomicron triglyceride fatty acids directly into the circulation as free fatty acids (FFAs) during lipoprotein lipase hydrolysis may contribute to the elevated total FFAs seen in insulin-resistant states...
  4. ncbi Effect of orlistat in overweight and obese patients with type 2 diabetes treated with metformin
    John M Miles
    Lipid and Diabetes Research Center, St Lukes Hospital, Kansas City, Missouri, USA
    Diabetes Care 25:1123-8. 2002
    ..The purpose of this study was to assess the effect of orlistat, a gastrointestinal lipase inhibitor, on body weight, glycemic control, and cardiovascular risk factors in metformin-treated type 2 diabetic patients...
  5. ncbi Contribution of triglyceride-rich lipoproteins to plasma free fatty acids
    J M Miles
    Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    Horm Metab Res 39:726-9. 2007
    ..If systemic spillover is increased in insulin resistant states such as diabetes, this could represent a mechanism contributing to the abnormal increases in plasma concentrations of free fatty acids in that condition...
  6. ncbi No, the glycaemic target in the critically ill should not be < or = 6.1 mmol/l
    J M Miles
    Endocrine Research Unit, Mayo Clinic, Rochester, MN, USA
    Diabetologia 51:916-20. 2008
  7. ncbi A role for the glycemic index in preventing or treating diabetes?
    John M Miles
    Division of Endocrinology, Metabolism and Nutrition, Mayo Clinic, Rochester, MN 55905, USA
    Am J Clin Nutr 87:1-2. 2008
  8. ncbi Counterpoint: visceral adiposity is not causally related to insulin resistance
    John M Miles
    Endocrine Research Unit, Division of Endocrinology, Metabolism and Nutrition, Mayo Clinic, Rochester, Minnesota 55905, USA
    Diabetes Care 28:2326-8. 2005
  9. ncbi Energy expenditure in hospitalized patients: implications for nutritional support
    John M Miles
    Endocrine Research Unit, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Mayo Clin Proc 81:809-16. 2006
    ..Additional research in hospitalized patients on total energy expenditure and on the relationship between severity of illness and energy expenditure is needed...
  10. ncbi Systemic and forearm triglyceride metabolism: fate of lipoprotein lipase-generated glycerol and free fatty acids
    John M Miles
    Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota, USA
    Diabetes 53:521-7. 2004
    ..They further suggest that LPL-mediated fatty acid uptake is an inefficient process, but may be more efficient in muscle than in adipose tissue...
  11. ncbi Nocturnal and postprandial free fatty acid kinetics in normal and type 2 diabetic subjects: effects of insulin sensitization therapy
    John M Miles
    Mid America Heart Institute of Saint Luke s Hospital, University of Missouri Kansas City, Kansas City, MO, USA
    Diabetes 52:675-81. 2003
    ..In summary, nocturnal and postprandial FFA R(a) is increased in type 2 diabetes. Postprandial lipolysis appears to be preferentially improved by thiazolidinediones compared with nocturnal lipolysis...
  12. ncbi Triacetin: a potential parenteral nutrient
    J W Bailey
    Department of Medicine, Mayo Medical School, Rochester, Minnesota 55905
    JPEN J Parenter Enteral Nutr 15:32-6. 1991
    ..These preliminary data indicate that triacetin may have a future role as a parenteral nutrient, and that further studies of its use are warranted...
  13. pmc Estrogen supplementation selectively enhances hypothalamo-pituitary sensitivity to ghrelin in postmenopausal women
    Petra Kok
    Department of Internal Medicine, Mayo School of Graduate Medical Education, Clinical Translational Science Center, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 93:4020-6. 2008
    ..The hypothesis is relevant to understanding the basis of hyposomatotropism in aging and other relatively hypogonadal states...
  14. pmc Pituitary and/or peripheral estrogen-receptor alpha regulates follicle-stimulating hormone secretion, whereas central estrogenic pathways direct growth hormone and prolactin secretion in postmenopausal women
    Mihaela Cosma
    Endocrine Research Unit, Department of Internal Medicine, Mayo Medical and Graduate Schools of Medicine, Mayo Clinic, 200 First Street S W, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 93:951-8. 2008
    ..Estradiol (E(2)) stimulates GH and prolactin secretion and suppresses FSH secretion in postmenopausal women. Whether central nervous system (CNS) or pituitary mechanisms (or both) mediate such actions is not known...
  15. ncbi Calcium, magnesium, and phosphorus metabolism in dogs given intravenous triacetin
    J W Bailey
    Endocrine Research Unit, Mayo Clinic and Medical School, Rochester, MN 55905
    Am J Clin Nutr 49:385-8. 1989
    ..A short-chain triglyceride administered to dogs at a rate approximating resting energy expenditure has no demonstrable adverse effects on mineral metabolism...
  16. pmc Pre- versus postmenopausal age, estradiol, and peptide-secretagogue type determine pulsatile growth hormone secretion in healthy women: studies using submaximal agonist drive and an estrogen clamp
    Susan B Hudson
    Department of Obstetrics and Gynecology, Mayo School of Graduate Medical Education, Clinical Translational Research Center, Mayo Clinic, Rochester, Minnesota 55905
    J Clin Endocrinol Metab 95:353-60. 2010
    ..GH-releasing peptide (GHRP), GHRH, and somatostatin are physiological regulators of pulsatile GH secretion...
  17. ncbi Dual secretagogue drive of burst-like growth hormone secretion in postmenopausal compared with premenopausal women studied under an experimental estradiol clamp
    Dana Erickson
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Medical and Graduate Schools of Medicine, General Clinical Research Center, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 89:4746-54. 2004
    ....
  18. pmc Gonadal status and body mass index jointly determine growth hormone (GH)-releasing hormone/GH-releasing peptide synergy in healthy men
    Remberto C Paulo
    Department of Pediatrics, Endocrine Research Unit, Clinical Translational Research Center, Mayo Medical and Graduate Schools, Mayo Clinic, Rochester, Minnesota 55901, USA
    J Clin Endocrinol Metab 93:944-50. 2008
    ..The issue is important in designing GH-stimulation regimens that are relatively insensitive to both gonadal status and adiposity...
  19. ncbi Splanchnic spillover of extracellular lipase-generated fatty acids in overweight and obese humans
    Robert H Nelson
    Endocrine Research Unit, Division of Endocrinology, Metabolism, Diabetes and Nutrition, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Diabetes 56:2878-84. 2007
    ..The present study was undertaken to determine whether spillover occurs in the splanchnic bed of humans...
  20. pmc Aromatase and 5alpha-reductase inhibition during an exogenous testosterone clamp unveils selective sex steroid modulation of somatostatin and growth hormone secretagogue actions in healthy older men
    Johannes D Veldhuis
    Department of Internal Medicine and Pediatrics, Endocrine Research Unit, Clinical Translational Research Center, Mayo Medical and Graduate Schools, Mayo Clinic, Rochester Minnesota 55901, USA
    J Clin Endocrinol Metab 94:973-81. 2009
    ..How endogenous testosterone (Te), 5alpha-dihydrotestosterone (DHT), and estradiol (E(2)) regulate pulsatile GH secretion is not understood...
  21. pmc Preservation of GHRH and GH-releasing peptide-2 efficacy in young men with experimentally induced hypogonadism
    Johannes D Veldhuis
    Endocrine Research Unit, Mayo School of Graduate Medical Education, Clinical Translational Science Center, Mayo Clinic, Rochester, Minnesota 55905, USA
    Eur J Endocrinol 161:293-300. 2009
    ..Somatostatin (SS), GHRH, GH-releasing peptide (GHRP), and the sex-steroid milieu regulate GH secretion...
  22. pmc Estradiol supplementation in postmenopausal women attenuates suppression of pulsatile growth hormone secretion by recombinant human insulin-like growth factor type I
    Johannes D Veldhuis
    Department of Medicine, Mayo School of Graduate Medical Education, Clinical Translational Science Center, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 93:4471-8. 2008
    ..One possibility is that estrogen not only enhances stimulation by secretagogues but also attenuates negative feedback by systemic IGF-I. SITE: The study took place at an academic medical center...
  23. pmc Novel relationships of age, visceral adiposity, insulin-like growth factor (IGF)-I and IGF binding protein concentrations to growth hormone (GH) releasing-hormone and GH releasing-peptide efficacies in men during experimental hypogonadal clamp
    Johannes D Veldhuis
    Endocrine Research Unit, Mayo School of Graduate Medical Education, Clinical Translational Science Center, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 94:2137-43. 2009
    ..Sex steroids influence GH secretion in complex ways...
  24. pmc Testosterone supplementation in older men restrains insulin-like growth factor's dose-dependent feedback inhibition of pulsatile growth hormone secretion
    Johannes D Veldhuis
    Department of Medicine, Endocrine Research Unit, Mayo School of Graduate Medical Education, Clinical Translational Science Center, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 94:246-54. 2009
    ..The causal mechanisms are unknown. Candidates include deficient feedforward (stimulation) by endogenous secretagogues and excessive feedback (inhibition) by GH or IGF-I due to age and/or relative hypoandrogenemia...
  25. ncbi Estradiol potentiates ghrelin-stimulated pulsatile growth hormone secretion in postmenopausal women
    Johannes D Veldhuis
    Endocrine Research Unit, Department of Internal Medicine, Mayo School of Graduate Medical Education, General Clinical Research Center, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 91:3559-65. 2006
    ..Ghrelin and an estrogen-rich milieu individually amplify pulsatile GH secretion by increasing the amount of hormone released per burst. However, how these distinct agonists interact in controlling pulsatile GH output is not known...
  26. ncbi The effect of high-dose simvastatin on triglyceride-rich lipoprotein metabolism in patients with type 2 diabetes mellitus
    William L Isley
    Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic College of Medicine, Rochester, MN, USA
    J Lipid Res 47:193-200. 2006
    ..The effect of high-dose simvastatin on triglyceride-rich lipoprotein metabolism in patients with type 2 diabetes mellitus...
  27. pmc Complementary secretagogue pairs unmask prominent gender-related contrasts in mechanisms of growth hormone pulse renewal in young adults
    Cacia Soares-Welch
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo School of Graduate Medical Education, General Clinical Research Center, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 90:2225-32. 2005
    ..This inference upholds recent clinical precedence and yields valid predictions of sex differences in self-renewable GH pulsatility...
  28. ncbi The effect of high-dose simvastatin on free fatty acid metabolism in patients with type 2 diabetes mellitus
    William L Isley
    Endocrine Research Unit, Division of Endocrinology, Nutrition, and Metabolism, Mayo Clinic, Rochester, MN 55905, USA
    Metabolism 55:758-62. 2006
    ..These results suggest that the triglyceride-lowering effect of statins is not mediated through an effect on FFA metabolism...
  29. ncbi Ghrelin potentiates growth hormone secretion driven by putative somatostatin withdrawal and resists inhibition by human corticotropin-releasing hormone
    Johannes D Veldhuis
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Medical and Graduate Schools of Medicine, General Clinical Research Center, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 91:2441-6. 2006
    ..Beyond the capability of ghrelin to synergize with GHRH, little is known about multipeptide modulation of ghrelin's actions in humans...
  30. ncbi Glycemic control and nutrition in the intensive care unit
    M Molly McMahon
    Division of Endocrinology, Diabetes, Metabolism, Nutrition and Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Curr Opin Clin Nutr Metab Care 9:120-3. 2006
    ..Hospital clinicians frequently encounter hyperglycemia due to diabetes or the stress of critical illness in patients who are receiving nutrition support...
  31. ncbi Sex-steroid control of the aging somatotropic axis
    Johannes D Veldhuis
    Endocrine Research Unit, Department of Internal Medicine, Mayo School of Graduate Medical Education, General Clinical Research Center, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Endocrinol Metab Clin North Am 34:877-93, viii. 2005
  32. ncbi Testosterone supplementation in healthy older men drives GH and IGF-I secretion without potentiating peptidyl secretagogue efficacy
    Johannes D Veldhuis
    Department of Internal Medicine, Mayo Medical and Graduate Schools of Medicine, General Clinical Research Center, Mayo Clinic, Rochester, MN 55905, USA
    Eur J Endocrinol 153:577-86. 2005
    ..e. reduces opposition by hypothalamic somatostatin) and (iii) abdominal visceral fat (AVF) mass is a negative determinant of specific secretagogue-stimulated GH secretion...
  33. ncbi Effect of parenteral administration of short-chain triglycerides on leucine metabolism
    J W Bailey
    Department of Medicine, Mayo Clinic and Foundation, Rochester, MN 55905
    Am J Clin Nutr 58:912-6. 1993
    ..Because of its water solubility, lack of toxicity, and favorable effects on protein metabolism, further studies are warranted regarding the use of triacetin as a parenteral nutrient...
  34. ncbi Insulin in the early management of diabetic complications
    John M Miles
    Mayo Medical School, Rochester, Minnesota, USA
    J Assoc Physicians India 51:501-5. 2003
    ..Insulin therapy has favorable effects on endothelial function and lipids, especially compared with sulfonylureas. More information is needed on the effects of diabetes pharmacotherapy on cardiovascular outcomes...
  35. ncbi The use of orlistat in the treatment of obesity, dyslipidaemia and Type 2 diabetes
    Robert H Nelson
    Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    Expert Opin Pharmacother 6:2483-91. 2005
    ..Orlistat should only be prescribed for individuals who are motivated to adhere to lifestyle modifications, especially dietary fat restriction...
  36. ncbi Triglyceride uptake and lipoprotein lipase-generated fatty acid spillover in the splanchnic bed of dogs
    Robert H Nelson
    Endocrine Research Unit, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Diabetes 56:1850-5. 2007
    ..005), the latter representing calculation of spillover between arterial and hepatic venous blood without portal venous data. Metabolism of chylomicron triglycerides in visceral fat may be an important source of portal venous FFAs...
  37. ncbi A new method for the study of chylomicron kinetics in vivo
    Y Park
    Department of Medicine, University of Missouri Kansas City, St Luke s Hospital, Kansas City, Missouri 64111, USA
    Am J Physiol Endocrinol Metab 279:E1258-63. 2000
    ..kg(-1). h(-1), equal to the presumed ingestion rate. In summary, a radiolabeled intravenous lipid emulsion is able to accurately estimate chylomicron TG R(a) and therefore can be used to measure in vivo fat absorption rates...
  38. doi Can serum beta-hydroxybutyrate be used to diagnose diabetic ketoacidosis?
    Mae Sheikh-Ali
    Division of Endocrinology, Diabetes, Nutrition, and Metabolism, Mayo Clinic, Rochester, Minnesota 55905, USA
    Diabetes Care 31:643-7. 2008
    ..The present study was undertaken to determine whether quantitative measurement of a ketone body anion could be used to diagnose DKA...
  39. ncbi Measurement of human chylomicron triglyceride clearance with a labeled commercial lipid emulsion
    Y Park
    University of Missouri Kansas City, Department of Medicine and Cardiovascular Research Department, Mid America Heart Institute, Saint Luke s Hospital, 64111, USA
    Lipids 36:115-20. 2001
    ..The results indicate that a radiolabeled commercial lipid emulsion is metabolized in a fashion similar to native chylomicron TG, and thus can be used to study chylomicron TG kinetics...
  40. ncbi Bilateral carotid body paraganglioma
    Nicholas W W Choong
    Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Mayo Clin Proc 79:681. 2004
  41. ncbi Myocardial uptake of circulating triglycerides in nondiabetic patients with heart disease
    Robert H Nelson
    Endocrine Research Unit, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Diabetes 56:527-30. 2007
    ..5%). These results indicate that circulating triglycerides may be a significant source of fatty acids for myocardial respiration...
  42. ncbi What does the measurement of whole-body fatty acid rate of appearance in plasma by using a fatty acid tracer really mean?
    Bettina Mittendorfer
    Department of Internal Medicine and Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Diabetes 52:1641-8. 2003
    ....
  43. ncbi A multicompartmental model of in vivo adipose tissue glycerol kinetics and capillary permeability in lean and obese humans
    Simon W Coppack
    Diabetes and Metabolic Medicine, St Bartholomew s and The London School of Medicine, London, UK
    Diabetes 54:1934-41. 2005
    ..45, P < 0.05). Our results support previous estimates of interstitial glycerol concentration within adipose tissue and reveal capillary diffusion capacity is reduced in obesity...
  44. ncbi Nutritional support in stroke: a balanced meal or a feast?
    John M Miles
    Neurocrit Care 1:283-5. 2004

Research Grants7

  1. FFA Production From Triglyceride-Rich Lipoproteins
    John Miles; Fiscal Year: 2009
    ..Dietary fat may contribute to FFAs by a process known as "spillover", which occurs during fat storage. This work is a comprehensive evaluation of the importance of spillover as a contributor to FFAs. ..
  2. FFA Production From Triglyceride-Rich Lipoproteins
    John M Miles; Fiscal Year: 2010
    ..Dietary fat may contribute to FFAs by a process known as "spillover", which occurs during fat storage. This work is a comprehensive evaluation of the importance of spillover as a contributor to FFAs. ..
  3. FFA Production From Triglyceride-Rich Lipoproteins
    John Miles; Fiscal Year: 2006
    ..These studies will provide new insights into the regulation of FFA metabolism in humans. ..