Michelle M Mielke

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Plasma sphingomyelins are associated with cognitive progression in Alzheimer's disease
    Michelle M Mielke
    Department of Psychiatry, Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Alzheimers Dis 27:259-69. 2011
  2. pmc Fornix integrity and hippocampal volume predict memory decline and progression to Alzheimer's disease
    Michelle M Mielke
    Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Alzheimers Dement 8:105-13. 2012
  3. pmc Serum ceramides increase the risk of Alzheimer disease: the Women's Health and Aging Study II
    Michelle M Mielke
    Division of Epidemiology, College of Medicine, Mayo Clinic, Rochester, MN, USA
    Neurology 79:633-41. 2012
  4. pmc Indicators of amyloid burden in a population-based study of cognitively normal elderly
    Michelle M Mielke
    Division of Epidemiology, College of Medicine, Mayo Clinic, Rochester, MN, USA
    Neurology 79:1570-7. 2012
  5. pmc Assessing the temporal relationship between cognition and gait: slow gait predicts cognitive decline in the Mayo Clinic Study of Aging
    Michelle M Mielke
    Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, 200 First Street S W, Rochester, MN 55905, USA
    J Gerontol A Biol Sci Med Sci 68:929-37. 2013
  6. pmc Sex-specific risk of cardiovascular disease and cognitive decline: pregnancy and menopause
    Virginia M Miller
    Departments of Surgery and Physiology and Biomedical Engineering, 200 1st St SW, Rochester, MN 55905, USA
    Biol Sex Differ 4:6. 2013
  7. pmc Higher risk of progression to dementia in mild cognitive impairment cases who revert to normal
    Rosebud O Roberts
    From the Divisions of Epidemiology R O R, M M M, Y E G, W A R, R C P and Biomedical Statistics and Informatics R H C V S P, T J H C, Department of Health Sciences Research Department of Neurology R O R, D S K, B F B, R C P Department of Psychiatry and Psychology R J I and Division of Primary Care Internal Medicine, Department of Internal Medicine E G T, Mayo Clinic, Rochester, MN and Departments of Psychiatry and Psychology and Neurology Y E G, Mayo Clinic, Scottsdale, AZ
    Neurology 82:317-25. 2014
  8. pmc Selective worsening of brain injury biomarker abnormalities in cognitively normal elderly persons with β-amyloidosis
    David S Knopman
    Mayo Clinic Alzheimer s Disease Research Center, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    JAMA Neurol 70:1030-8. 2013
  9. pmc Serum sphingomyelins and ceramides are early predictors of memory impairment
    Michelle M Mielke
    Department of Psychiatry, Division of Geriatric Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 550 North Broadway, Suite 308, Baltimore, MD 21205, USA
    Neurobiol Aging 31:17-24. 2010
  10. pmc Diabetes and elevated hemoglobin A1c levels are associated with brain hypometabolism but not amyloid accumulation
    Rosebud O Roberts
    Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota
    J Nucl Med 55:759-64. 2014

Collaborators

Detail Information

Publications57

  1. pmc Plasma sphingomyelins are associated with cognitive progression in Alzheimer's disease
    Michelle M Mielke
    Department of Psychiatry, Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Alzheimers Dis 27:259-69. 2011
    ..These results suggest that increased SM/ceramide and DHSM/DHCer ratios dose-dependently predict slower progression among AD patients and may be sensitive blood-based biomarkers for clinical progression...
  2. pmc Fornix integrity and hippocampal volume predict memory decline and progression to Alzheimer's disease
    Michelle M Mielke
    Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Alzheimers Dement 8:105-13. 2012
    ....
  3. pmc Serum ceramides increase the risk of Alzheimer disease: the Women's Health and Aging Study II
    Michelle M Mielke
    Division of Epidemiology, College of Medicine, Mayo Clinic, Rochester, MN, USA
    Neurology 79:633-41. 2012
    ..The aim of this study was to examine whether serum ceramides and sphingomyelins (SM) were associated with an increased risk of all-cause dementia and Alzheimer disease (AD)...
  4. pmc Indicators of amyloid burden in a population-based study of cognitively normal elderly
    Michelle M Mielke
    Division of Epidemiology, College of Medicine, Mayo Clinic, Rochester, MN, USA
    Neurology 79:1570-7. 2012
    ..The identification of inexpensive and noninvasive screening variables that can identify individuals who have significant amyloid accumulation would reduce screening costs...
  5. pmc Assessing the temporal relationship between cognition and gait: slow gait predicts cognitive decline in the Mayo Clinic Study of Aging
    Michelle M Mielke
    Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, 200 First Street S W, Rochester, MN 55905, USA
    J Gerontol A Biol Sci Med Sci 68:929-37. 2013
    ..The association between gait speed and cognition has been reported; however, there is limited knowledge about the temporal associations between gait slowing and cognitive decline among cognitively normal individuals...
  6. pmc Sex-specific risk of cardiovascular disease and cognitive decline: pregnancy and menopause
    Virginia M Miller
    Departments of Surgery and Physiology and Biomedical Engineering, 200 1st St SW, Rochester, MN 55905, USA
    Biol Sex Differ 4:6. 2013
    ..Research into specific sex differences for these disease processes with attention to an individual's sex chromosomal complement and hormonal status is important and timely...
  7. pmc Higher risk of progression to dementia in mild cognitive impairment cases who revert to normal
    Rosebud O Roberts
    From the Divisions of Epidemiology R O R, M M M, Y E G, W A R, R C P and Biomedical Statistics and Informatics R H C V S P, T J H C, Department of Health Sciences Research Department of Neurology R O R, D S K, B F B, R C P Department of Psychiatry and Psychology R J I and Division of Primary Care Internal Medicine, Department of Internal Medicine E G T, Mayo Clinic, Rochester, MN and Departments of Psychiatry and Psychology and Neurology Y E G, Mayo Clinic, Scottsdale, AZ
    Neurology 82:317-25. 2014
    ..To estimate rates of progression from mild cognitive impairment (MCI) to dementia and of reversion from MCI to being cognitively normal (CN) in a population-based cohort...
  8. pmc Selective worsening of brain injury biomarker abnormalities in cognitively normal elderly persons with β-amyloidosis
    David S Knopman
    Mayo Clinic Alzheimer s Disease Research Center, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    JAMA Neurol 70:1030-8. 2013
    ....
  9. pmc Serum sphingomyelins and ceramides are early predictors of memory impairment
    Michelle M Mielke
    Department of Psychiatry, Division of Geriatric Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 550 North Broadway, Suite 308, Baltimore, MD 21205, USA
    Neurobiol Aging 31:17-24. 2010
    ..Results suggest serum SM and ceramides vary according to the timing of the onset of memory impairment and may be good pre-clinical predictors, or biomarkers, of memory impairment: a deficit observed early in AD pathogenesis...
  10. pmc Diabetes and elevated hemoglobin A1c levels are associated with brain hypometabolism but not amyloid accumulation
    Rosebud O Roberts
    Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota
    J Nucl Med 55:759-64. 2014
    ..We investigated the associations of type 2 diabetes with amyloid accumulation measured using (11)C-Pittsburgh compound B ((11)C-PiB) and brain hypometabolism measured using (18)F-FDG PET...
  11. pmc Rates of β-amyloid accumulation are independent of hippocampal neurodegeneration
    Clifford R Jack
    From the Departments of Radiology C R J, P V, M L S, J L G, V L, B E G, Health Sciences Research H J W, M M M, S D W, V S P, and Neurology D S K, R C P, Mayo Clinic and Foundation, Rochester, MN
    Neurology 82:1605-12. 2014
    ....
  12. pmc Practice effects and longitudinal cognitive change in normal aging vs. incident mild cognitive impairment and dementia in the Mayo Clinic Study of Aging
    Mary M Machulda
    a Department of Psychiatry and Psychology, College of Medicine, Mayo Clinic, Rochester, MN, USA
    Clin Neuropsychol 27:1247-64. 2013
    ..Modeling cognitive change in an epidemiologic sample may serve as a useful benchmark for evaluating cognitive change in future intervention studies. ..
  13. pmc Head trauma and in vivo measures of amyloid and neurodegeneration in a population-based study
    Michelle M Mielke
    From the Divisions of Epidemiology M M Mielke, R O R, R C P, Y E G and Biomedical Statistics and Informatics H J W, S D W, Department of Health Sciences Research Departments of Neurology R S, D S K, R O R, R C P, Psychiatry and Psychology M M Machulda, and Radiology P V, V J L, C R J, Mayo Clinic, Rochester, MN and Departments of Psychiatry, Psychology, and Neurology Y E G, Mayo Clinic, Scottsdale, AZ
    Neurology 82:70-6. 2014
    ..We determined whether head trauma was associated with amyloid deposition and neurodegeneration among individuals who were cognitively normal (CN) or had mild cognitive impairment (MCI)...
  14. pmc The association of neuropsychiatric symptoms in MCI with incident dementia and Alzheimer disease
    Paul B Rosenberg
    Johns Hopkins University School of Medicine, Division of Geriatric Psychiatry and Neuropsychiatry, Baltimore, MD 21224, USA
    Am J Geriatr Psychiatry 21:685-95. 2013
    ..Among persons with MCI, depression and anxiety have been associated with an increased risk of incident dementia. We examined whether neuropsychiatric symptoms in MCI increased the risk of incident dementia (all-cause) and incident AD...
  15. pmc Plasma ceramides are altered in mild cognitive impairment and predict cognitive decline and hippocampal volume loss
    Michelle M Mielke
    Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Alzheimers Dement 6:378-85. 2010
    ..The present objective was to examine whether plasma ceramides varied by AD severity in a well-characterized clinic sample and were associated with cognitive decline and hippocampal volume loss over 1 year...
  16. pmc Effects of Food and Drug Administration-approved medications for Alzheimer's disease on clinical progression
    Michelle M Mielke
    Department of Psychiatry, Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Alzheimers Dement 8:180-7. 2012
    ..Given this response and existence of side effects, we sought to quantify medication use and benefits in a population-based study of incident AD cases...
  17. pmc A prospective study of chronic obstructive pulmonary disease and the risk for mild cognitive impairment
    Balwinder Singh
    Department of Neurology, Mayo Clinic, Rochester, Minnesota2Department of Clinical Neuroscience, University of North Dakota School of Medicine and Health Sciences, Fargo
    JAMA Neurol 71:581-8. 2014
    ..However, few studies have assessed whether COPD, a potentially modifiable factor, is associated with an increased risk for MCI and whether the relation is specific to the type of MCI...
  18. pmc Association of type 2 diabetes with brain atrophy and cognitive impairment
    Rosebud O Roberts
    From the Division of Epidemiology, Department of Health Sciences Research R O R, M M M, Y E G, W A R, R C P, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research S A P, V S P, and Departments of Neurology R O R, D S K, B F B, W A R, R C P, Radiology K K, G M P, M L S, C R J, and Psychiatry and Psychology R J I, Mayo Clinic, Rochester, MN and Departments of Psychiatry and Psychology Y E G and Neurology Y E G, Mayo Clinic, Scottsdale, AZ
    Neurology 82:1132-41. 2014
    ..We investigated the associations of diabetes and hypertension with imaging biomarkers (markers of neuronal injury and ischemic damage) and with cognition in a population-based cohort without dementia...
  19. pmc Brain injury biomarkers are not dependent on β-amyloid in normal elderly
    David S Knopman
    Department of Neurology, Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, MN Mayo Clinic Alzheimer s Disease Research Center, Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, MN
    Ann Neurol 73:472-80. 2013
    ..The characteristics of the sNAP group are poorly understood...
  20. pmc Amyloid-first and neurodegeneration-first profiles characterize incident amyloid PET positivity
    Clifford R Jack
    From the Departments of Radiology C R J, V L, P V, D T J, M L S, J L G, B E G, Health Sciences Research H J W, S D W, M M M, V S P, and Neurology D S K, R C P, Mayo Clinic and Foundation, Rochester, MN
    Neurology 81:1732-40. 2013
    ..To estimate the incidence of and to characterize cognitive and imaging findings associated with incident amyloid PET positivity...
  21. pmc Cardiac disease associated with increased risk of nonamnestic cognitive impairment: stronger effect on women
    Rosebud O Roberts
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    JAMA Neurol 70:374-82. 2013
    ..Nonamnestic mild cognitive impairment, a putative precursor of vascular and other non-Alzheimer dementias, is hypothesized to have a vascular etiology...
  22. pmc Cerebrospinal fluid profiles and prospective course and outcome in patients with amnestic mild cognitive impairment
    Ozioma C Okonkwo
    Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Arch Neurol 68:113-9. 2011
    ..To examine the effect of specific cerebrospinal fluid (CSF) profiles on the rate of cognitive decline, disease progression, and risk of conversion to Alzheimer disease (AD) dementia in patients with amnestic mild cognitive impairment (MCI)...
  23. pmc Effects of general medical health on Alzheimer's progression: the Cache County Dementia Progression Study
    Jeannie Marie S Leoutsakos
    Department of Psychiatry, Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Int Psychogeriatr 24:1561-70. 2012
    ..We sought to quantify the relationship in a population-based study of incident AD, and to compare global comorbidity ratings to counts of comorbid conditions and medications as predictors of AD progression...
  24. pmc DTI analyses and clinical applications in Alzheimer's disease
    Kenichi Oishi
    The Russell H Morgan Department of Radiology and Radiological Science, School of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA
    J Alzheimers Dis 26:287-96. 2011
    ..Application of these findings in clinical practice remains to be demonstrated...
  25. ncbi request reprint Apolipoprotein E genotype and lifetime cognitive decline
    Nicholas A Kozauer
    Division of Geriatric and Neuropsychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Int Psychogeriatr 20:109-23. 2008
    ..The relationship of apolipoprotein E (APOE) genotype to lifetime cognitive decline was examined over 22 years in a large community-based population study...
  26. pmc Longitudinal, region-specific course of diffusion tensor imaging measures in mild cognitive impairment and Alzheimer's disease
    Milap A Nowrangi
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine and Johns Hopkins Bayview Medical Center, Baltimore, MD, USA
    Alzheimers Dement 9:519-28. 2013
    ..There have not been many studies establishing its longitudinal utility...
  27. pmc A lipid storage-like disorder contributes to cognitive decline in HIV-infected subjects
    Veera Venkata Ratnam Bandaru
    From the Department of Neurology, Division of Neuroimmunology and Neurological Infections V V R B, N S, J C M, C P, P C, N J H, and the Department of Psychiatry N J H, The Johns Hopkins University, School of Medicine, Baltimore, MD the Department of Health Sciences Research M M M, Division of Epidemiology, The Mayo Clinic, Rochester, MN HIV Neurobehavioral Research Program and Department of Psychiatry I G, S L, School of Medicine, University of California, San Diego, La Jolla the Department of Psychiatry L C, S M, University of Hawaii, John A Burns School of Medicine, Honolulu and the Department of Neurology V W, Specialized Neurosciences Research Program, University of Puerto Rico Medical Sciences Campus, San Juan
    Neurology 81:1492-9. 2013
    ..In this multicenter cohort study, we sought to identify prognostic and associative metabolic indicators for HIV-associated neurocognitive disorders (HAND)...
  28. pmc Disturbance in cerebral spinal fluid sphingolipid content is associated with memory impairment in subjects infected with the human immunodeficiency virus
    Michelle M Mielke
    Department of Psychiatry, Richard T Johnson Division of Neuroimmunology and Neurological Infections, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Neurovirol 16:445-56. 2010
    ..These findings suggest that the sphingomyelin:ceramide ratio for C18:0 may be a reasonable surrogate marker for memory dysfunction in HIV-infected subjects...
  29. pmc Cerebrospinal fluid abnormalities and rate of decline in everyday function across the dementia spectrum: normal aging, mild cognitive impairment, and Alzheimer disease
    Ozioma C Okonkwo
    Department of Neurology, Johns Hopkins School of Medicine, 1620 McElderry St, Reed Hall East 2, Baltimore, MD 21205, USA
    Arch Neurol 67:688-96. 2010
    ..To investigate the effect of cerebrospinal fluid (CSF) abnormalities on the rate of decline in everyday function in normal aging, mild cognitive impairment (MCI), and mild Alzheimer disease (AD)...
  30. pmc Interaction between vascular factors and the APOE ε4 allele in predicting rate of progression in Alzheimer's disease
    Michelle M Mielke
    Department of Psychiatry, Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    J Alzheimers Dis 26:127-34. 2011
    ..Among individuals with a history of stroke or myocardial infarction at baseline, progression of AD is influenced by APOE ε4 carrier status and varies by time after AD diagnosis...
  31. pmc Subtle gait changes in patients with REM sleep behavior disorder
    Eric M McDade
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Mov Disord 28:1847-53. 2013
    ..01). Probable RBD is associated with subtle gait changes prior to overt clinical parkinsonism. Diagnosis of probable RBD supplemented by gait analysis may help as a screening tool for disorders of α-synuclein...
  32. pmc 18F-fluorodeoxyglucose positron emission tomography, aging, and apolipoprotein E genotype in cognitively normal persons
    David S Knopman
    Department of Neurology, Mayo Clinic and Foundation, Rochester, MN, USA Mayo Clinic Alzheimer s Disease Research Center, Mayo Clinic and Foundation, Rochester, MN, USA Electronic address
    Neurobiol Aging 35:2096-106. 2014
    ..The posterior cingulate and/or precuneus and lateral parietal regions have a unique vulnerability to reductions in glucose metabolic rate as a function both of age and carriage of an APOE ε4 allele...
  33. pmc Plasma ceramide and glucosylceramide metabolism is altered in sporadic Parkinson's disease and associated with cognitive impairment: a pilot study
    Michelle M Mielke
    Departments of Health Science Research and Neurology, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 8:e73094. 2013
    ..We hypothesized that plasma levels of lipids involved in ceramide metabolism would also be altered in PD non-GBA mutation carriers and associated with worse cognition...
  34. pmc Chronic obstructive pulmonary disease and association with mild cognitive impairment: the Mayo Clinic Study of Aging
    Balwinder Singh
    Department of Neurology, Mayo Clinic, Rochester, MN Department of Clinical Neuroscience, University of North Dakota School of Medicine and Health Sciences, Fargo, ND Electronic address
    Mayo Clin Proc 88:1222-30. 2013
    ..To investigate the association of chronic obstructive pulmonary disease (COPD) with mild cognitive impairment (MCI) and MCI subtype: amnestic MCI and nonamnestic MCI, in a population-based study of elderly patients...
  35. pmc Association of diabetes with amnestic and nonamnestic mild cognitive impairment
    Rosebud O Roberts
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA Department of Neurology, Mayo Clinic, Rochester, MN, USA Electronic address
    Alzheimers Dement 10:18-26. 2014
    ..We examined the association of type 2 diabetes with mild cognitive impairment (MCI) and MCI subtype (aMCI and naMCI) overall and by sex...
  36. pmc Depressive symptoms predict incident cognitive impairment in cognitive healthy older women
    Paul B Rosenberg
    Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins Bayview Medical Center, Baltimore MD 21224, USA
    Am J Geriatr Psychiatry 18:204-11. 2010
    ..The authors sought to examine whether depression increased the risk of incident cognitive impairment in a longitudinal study of older women...
  37. pmc Diffusion tensor imaging of neuropsychiatric symptoms in mild cognitive impairment and Alzheimer's dementia
    Sarah K Tighe
    Johns Hopkins University School of Medicine, Department of Psychiatry, Baltimore, MD, USA
    J Neuropsychiatry Clin Neurosci 24:484-8. 2012
    ..Further imaging studies are necessary to elucidate the role of the AC in the pathophysiology of neuropsychiatric symptoms in AD and MCI...
  38. pmc Neuropsychiatric symptoms in MCI subtypes: the importance of executive dysfunction
    Paul B Rosenberg
    Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Int J Geriatr Psychiatry 26:364-72. 2011
    ..Since dementia has been associated with a range of neuropsychiatric symptoms (NPS), we sought to examine the prevalence of NPS in MCI and its subtypes...
  39. ncbi request reprint Progranulin protein levels are differently regulated in plasma and CSF
    Alexandra M Nicholson
    From the Department of Neuroscience A M N, N A F, A W, N J R, R R and Division of Biomedical Statistics and Informatics C S T, Mayo Clinic, Jacksonville, FL and Division of Epidemiology, Department of Health Sciences Research M M M, R O R and Department of Neurology R O R, B F B, D S K, R C P, Mayo Clinic, Rochester, MN
    Neurology 82:1871-8. 2014
    ..We aimed to investigate the relationship between plasma and CSF progranulin (PGRN) levels...
  40. pmc Vascular risk factors and neuropsychiatric symptoms in Alzheimer's disease: the Cache County Study
    Martin Steinberg
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins Bayview Medical Center, Baltimore, MD, USA
    Int J Geriatr Psychiatry 29:153-9. 2014
    ..Knowledge of potentially modifiable risk factors for neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD) is important. This study longitudinally explores modifiable vascular risk factors for NPS in AD...
  41. pmc The fornix sign: a potential sign for Alzheimer's disease based on diffusion tensor imaging
    Kenichi Oishi
    Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neuroimaging 22:365-74. 2012
    ..We investigated a simple imaging sign for Alzheimer's disease (AD), using diffusion tensor imaging (DTI). We hypothesized that a reduction in fractional anisotropy (FA) in the fornix could be utilized as an imaging sign...
  42. pmc Brain β-amyloid load approaches a plateau
    Clifford R Jack
    From the Departments of Radiology, Mayo Clinic, Rochester, MN, USA
    Neurology 80:890-6. 2013
    ..To model the temporal trajectory of β-amyloid accumulation using serial amyloid PET imaging...
  43. pmc Evaluation of the effect of systolic blood pressure and pulse pressure on cognitive function: the Women's Health and Aging Study II
    Sevil Yasar
    Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 6:e27976. 2011
    ..There is mixed evidence regarding the effects of late life elevated SBP or PP on cognitive function, and limited information on the role of female gender...
  44. pmc Association of mediterranean diet with mild cognitive impairment and Alzheimer's disease: a systematic review and meta-analysis
    Balwinder Singh
    Department of Neurology, Mayo Clinic, Rochester, MN, USA Department of Clinical Neuroscience, University of North Dakota School of Medicine and Health Sciences, Fargo, ND, USA
    J Alzheimers Dis 39:271-82. 2014
    ..To conduct a systematic review of all studies to determine whether there is an association between the Mediterranean diet (MeDi) and cognitive impairment...
  45. pmc Caloric intake, aging, and mild cognitive impairment: a population-based study
    Yonas E Geda
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA
    J Alzheimers Dis 34:501-7. 2013
    ..96, 95% CI 1.26-3.06, p = 0.003) as compared to the reference group. Therefore, high caloric intake was associated with MCI but not moderate caloric intake. This association is not necessarily a cause-effect relationship...
  46. ncbi request reprint Low serum potassium in mid life associated with decreased cerebrospinal fluid Abeta42 in late life
    Michelle M Mielke
    Center on Aging and Health, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Alzheimer Dis Assoc Disord 20:30-6. 2006
    ..Nonetheless, serum potassium is a modifiable risk factor and further examination of the potassium-dementia relationship is warranted...
  47. pmc Rates of depression in individuals with pathologic but not clinical Alzheimer disease are lower than those in individuals without the disease: findings from the Baltimore Longitudinal Study on Aging (BLSA)
    Melissa D Morgan
    Johns Hopkins University, Baltimore, MD 21224, USA
    Alzheimer Dis Assoc Disord 21:199-204. 2007
    ..These findings suggest that depression is a risk factor for AD in the presence of AD pathology, but depression is not a risk factor for AD pathology...
  48. pmc Comparison of conventional ELISA with electrochemiluminescence technology for detection of amyloid-β in plasma
    Esther S Oh
    Department of Medicine, Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    J Alzheimers Dis 21:769-73. 2010
    ..However, the advantages of electrochemiluminescence detection technology include short processing time and small sample volume. This comparison demonstrates the need for a further study in optimizing this system...
  49. ncbi request reprint Lipids and the pathogenesis of Alzheimer's disease: is there a link?
    Michelle M Mielke
    Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry, and the Alzheimer s Disease Research Center, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
    Int Rev Psychiatry 18:173-86. 2006
    ..Given the many possibilities through which lipids may be directly involved in or contribute to the pathogenesis of AD, the use of lipids as biomarkers for disease progression is discussed, as are other avenues for future research...
  50. pmc Predictors of new-onset depression after mild traumatic brain injury
    Vani Rao
    Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD, USA
    J Neuropsychiatry Clin Neurosci 22:100-4. 2010
    ..Identifying risk factors for mild TBI depression can aid in early diagnosis and treatment...
  51. pmc Alterations of the sphingolipid pathway in Alzheimer's disease: new biomarkers and treatment targets?
    Michelle M Mielke
    Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Bayview, Alpha Commons Building, 4th Floor, Room 454, Baltimore, MD 21224, USA
    Neuromolecular Med 12:331-40. 2010
    ..Lastly, the potential role of peripheral ceramides in AD pathogenesis is discussed, as well as the possible use of sphingolipids as biomarkers for AD...
  52. ncbi request reprint Transition to nursing home from assisted living is not associated with dementia or dementia-related problem behaviors
    Paul B Rosenberg
    Department of Psychiatry and Behavioral Sciences, Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins School of Medicine, Osler 320, 600 North Wolfe Street, Baltimore, MD, USA
    J Am Med Dir Assoc 7:73-8. 2006
    ..To examine risk factors for transition from assisted living (AL) care to skilled nursing facility (SNF) care in a random sample of adults residing in AL...
  53. pmc Identification of altered metabolic pathways in plasma and CSF in mild cognitive impairment and Alzheimer's disease using metabolomics
    Eugenia Trushina
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
    PLoS ONE 8:e63644. 2013
    ..Our data suggest metabolomics could advance our understanding of the early disease mechanisms shared in progression from CN to MCI and to AD...
  54. ncbi request reprint Hematologic risk factors of vascular disease and their relation to dementia
    Michelle M Mielke
    Center on Aging and Health and the Alzheimer Disease Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Dement Geriatr Cogn Disord 21:335-52. 2006
    ..A necessary step is to examine multiple hematologic factors simultaneously, rather than in isolation, to determine how these factors are interrelated...
  55. ncbi request reprint Caregiver assessment of patients' depression in Alzheimer disease: longitudinal analysis in a drug treatment study
    Paul B Rosenberg
    Department of Psychiatry and Behavioral Sciences, Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins University School of Medicine, 550 N Broadway 308, Baltimore, MD 21205, USA
    Am J Geriatr Psychiatry 13:822-6. 2005
    ..Caregiver input is important in the assessment of depression in Alzheimer disease (AD), but depression and subjective burden can bias this input...
  56. pmc Baseline serum cholesterol is selectively associated with motor speed and not rates of cognitive decline: the Women's Health and Aging Study II
    Michelle M Mielke
    Johns Hopkins University School of Medicine, Center on Aging and Health and Department of Psychiatry, Division of Geriatric Psychiatry and Behavioral Sciences, 550 N Broadway, Suite 308, Baltimore, MD 21205, USA
    J Gerontol A Biol Sci Med Sci 63:619-24. 2008
    ..We examined serum total and high-density lipoprotein (HDL) cholesterol, total-to-HDL ratio, and trajectories across cognitive domains...