JAMES MESCHIA

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. ncbi request reprint Clinically translated ischemic stroke genomics
    James F Meschia
    Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Stroke 35:2735-9. 2004
  2. pmc TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease
    Sruti Rayaprolu
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA
    Mol Neurodegener 8:19. 2013
  3. pmc Genomic risk profiling of ischemic stroke: results of an international genome-wide association meta-analysis
    James F Meschia
    Department of Neurology, Mayo Clinic, Jacksonville, Florida, United States of America
    PLoS ONE 6:e23161. 2011
  4. ncbi request reprint New advances in identifying genetic anomalies in stroke-prone probands
    James F Meschia
    Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Curr Neurol Neurosci Rep 4:420-6. 2004
  5. ncbi request reprint Correlation of proband and sibling stroke latency: the SWISS Study
    J F Meschia
    Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Neurology 64:1061-3. 2005
  6. pmc Phosphodiesterase 4D and 5-lipoxygenase activating protein in ischemic stroke
    James F Meschia
    Department of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA
    Ann Neurol 58:351-61. 2005
  7. pmc The Siblings With Ischemic Stroke Study (SWISS): a progress report
    James F Meschia
    Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, Florida 32224, USA
    Clin Med Res 4:12-21. 2006
  8. doi request reprint Mayo Acute Stroke Trial for Enhancing Recovery (MASTER) protocol
    James F Meschia
    Department of Neurology, Mayo Clinic, Jacksonville, Florida 32224, USA
    J Stroke Cerebrovasc Dis 19:299-310. 2010
  9. pmc Family history of stroke and severity of neurologic deficit after stroke
    J F Meschia
    Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Neurology 67:1396-402. 2006
  10. ncbi request reprint Diagnosis and invasive management of carotid atherosclerotic stenosis
    James F Meschia
    Department of Neurology, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224, USA
    Mayo Clin Proc 82:851-8. 2007

Research Grants

  1. Siblings With Ischemic Stroke Study (SWISS)
    JAMES MESCHIA; Fiscal Year: 2009
  2. ISGS: The Ischemic Stroke Genetics Study
    JAMES MESCHIA; Fiscal Year: 2006
  3. MULTICENTERED STUDY OF STROKE GENETICS
    JAMES MESCHIA; Fiscal Year: 2004

Detail Information

Publications76

  1. ncbi request reprint Clinically translated ischemic stroke genomics
    James F Meschia
    Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Stroke 35:2735-9. 2004
    ....
  2. pmc TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease
    Sruti Rayaprolu
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA
    Mol Neurodegener 8:19. 2013
    ..With this in mind we set out to assess the genetic association of the Alzheimer's disease-related risk variant in TREM2 (rs75932628, p.R47H) with other related neurodegenerative disorders...
  3. pmc Genomic risk profiling of ischemic stroke: results of an international genome-wide association meta-analysis
    James F Meschia
    Department of Neurology, Mayo Clinic, Jacksonville, Florida, United States of America
    PLoS ONE 6:e23161. 2011
    ..We present a meta-analysis of genome-wide association scans (GWAS) from 3 cohorts to identify the contribution of common variants to ischemic stroke risk...
  4. ncbi request reprint New advances in identifying genetic anomalies in stroke-prone probands
    James F Meschia
    Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Curr Neurol Neurosci Rep 4:420-6. 2004
    ..In the foreseeable future, prevention, diagnosis, and treatment will incorporate genetic data to refine and individualize management of cerebrovascular disease...
  5. ncbi request reprint Correlation of proband and sibling stroke latency: the SWISS Study
    J F Meschia
    Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Neurology 64:1061-3. 2005
    ..68; p < 0.0001), diabetes (r = 0.73; p < 0.0001), and hypertension (r = 0.63; p < 0.0001). In the authors' cohort of affected sibling pairs, inherited factors were important determinants of incident ischemic stroke latency...
  6. pmc Phosphodiesterase 4D and 5-lipoxygenase activating protein in ischemic stroke
    James F Meschia
    Department of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA
    Ann Neurol 58:351-61. 2005
    ..There was no evidence of association between variants of ALOX5AP and ischemic stroke. These data suggest that common variants in PDE4D may contribute to the genetic risk for ischemic stroke in multiple populations...
  7. pmc The Siblings With Ischemic Stroke Study (SWISS): a progress report
    James F Meschia
    Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, Florida 32224, USA
    Clin Med Res 4:12-21. 2006
    ..This report updates the progress of enrollment in the SWISS protocol, discusses barriers to pedigree completion and describes innovative approaches used by the SWISS investigators to enhance enrollment...
  8. doi request reprint Mayo Acute Stroke Trial for Enhancing Recovery (MASTER) protocol
    James F Meschia
    Department of Neurology, Mayo Clinic, Jacksonville, Florida 32224, USA
    J Stroke Cerebrovasc Dis 19:299-310. 2010
    ..TRIAL REGISTRATION: Clinicaltrials.gov identifier NCT00805792...
  9. pmc Family history of stroke and severity of neurologic deficit after stroke
    J F Meschia
    Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Neurology 67:1396-402. 2006
    ..A family history of stroke is an independent risk factor for stroke...
  10. ncbi request reprint Diagnosis and invasive management of carotid atherosclerotic stenosis
    James F Meschia
    Department of Neurology, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224, USA
    Mayo Clin Proc 82:851-8. 2007
    ..Randomized comparisons of endarterectomy vs stenting have been performed in average- and high-risk patients with asymptomatic and symptomatic carotid artery stenosis with mixed results...
  11. doi request reprint Whole genome approaches in ischemic stroke
    James F Meschia
    Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Stroke 40:S61-3. 2009
    ..The field of ischemic stroke genetics is moving beyond candidate gene studies into the realm of genomewide association studies. Such studies have resulted in discoveries in diverse, complex disorders...
  12. pmc Pharmacogenetics and stroke
    James F Meschia
    Mayo Clinic, Jacksonville, Fla 32224, USA
    Stroke 40:3641-5. 2009
    ..Physicians, pharmaceutical companies, regulatory agencies, and health insurers continue to grapple with how best to translate this burgeoning field into effective individualized medicine...
  13. pmc Racial disparities in awareness and treatment of atrial fibrillation: the REasons for Geographic and Racial Differences in Stroke (REGARDS) study
    James F Meschia
    Department of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA
    Stroke 41:581-7. 2010
    ..Differences in awareness and treatment of AF may contribute to racial and geographic disparities in stroke mortality. The objective was to examine predictors of awareness of the diagnosis of AF and treatment with warfarin...
  14. pmc New information on the genetics of stroke
    James F Meschia
    Cerebrovascular Division, Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Curr Neurol Neurosci Rep 11:35-41. 2011
    ....
  15. doi request reprint Genetic susceptibility to ischemic stroke
    James F Meschia
    Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Nat Rev Neurol 7:369-78. 2011
    ....
  16. pmc Siblings with ischemic stroke study: results of a genome-wide scan for stroke loci
    James F Meschia
    Department of Neurology, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224, USA
    Stroke 42:2726-32. 2011
    ..The Siblings With Ischemic Stroke Study was conducted to examine the associations between single-nucleotide polymorphisms (SNPs) and risk of stroke and stroke subtypes within pairs...
  17. ncbi request reprint Not so accidental outcomes following cerebrovascular accidents
    James F Meschia
    Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Cannaday Building 2 East, Jacksonville, FL 32224, USA
    Curr Neurol Neurosci Rep 4:341-2. 2004
  18. ncbi request reprint Familial clustering of stroke according to proband age at onset of presenting ischemic stroke
    James F Meschia
    Dept of Neurology, Mayo Clinic, Jacksonville, Fla, USA
    Stroke 34:e89-91. 2003
    ..We investigated the relationship between age and inherited risk of stroke...
  19. ncbi request reprint Reliability of the questionnaire for verifying stroke-free status
    James F Meschia
    Department of Neurology, Mayo Clinic, Jacksonville, Fla, USA
    Cerebrovasc Dis 17:218-23. 2004
    ..The Questionnaire for Verifying Stroke-Free Status (QVSS) is a practical instrument for confirming absence of previous symptomatic stroke or transient ischemic attack in control subjects participating in stroke research...
  20. ncbi request reprint New insights on thrombolytic treatment of acute ischemic stroke
    J F Meschia
    Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Curr Neurol Neurosci Rep 1:19-25. 2001
    ..Additional controlled investigations of intra-arterial thrombolytic therapy are needed. Neuroprotectants in combination with intravenous tPA have yet to show improved efficacy over the use of tPA alone...
  21. pmc The Ischemic Stroke Genetics Study (ISGS) Protocol
    James F Meschia
    Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA
    BMC Neurol 3:4. 2003
    ..Our aim is to investigate potential associations between hemostatic gene polymorphisms and ischemic stroke, with particular emphasis on detailed characterization of the phenotype...
  22. ncbi request reprint Ischaemic stroke: one or several complex genetic disorders?
    James F Meschia
    Department of Neurology, Davis 8B, Mayo Clinic, Jacksonville, FL 32224, USA
    Lancet Neurol 2:459. 2003
  23. ncbi request reprint Failure to wean from a ventilator caused by ANNA-1 seropositive paraneoplastic syndrome
    James F Meschia
    Department of Neurology, Mayo Clinic, Jacksonville, Florida 32224, USA
    Eur Neurol 50:112-4. 2003
  24. ncbi request reprint Management of acute ischemic stroke. What is the role of tPA and antithrombotic agents?
    J F Meschia
    Mayo Medical School, Rochester, Minnesota, USA
    Postgrad Med 107:85-6, 89-93. 2000
    ..Early initiation of rehabilitation can maximize stroke recovery. Whenever feasible, institutions should have stroke teams or units to streamline care and provide expertise for patients with acute stroke...
  25. ncbi request reprint Is hormone replacement a risk factor for ischemic stroke in women with factor V Leiden mutation?
    J F Meschia
    Department of Neurology, Mayo Clinic Jacksonville, Fla 32224, USA
    Arch Neurol 55:1137-9. 1998
    ..To describe a patient with multifocal cerebral ischemia whose only identified potential risk factors were use of postmenopausal hormone replacement and heterozygosity to factor V Leiden mutation...
  26. ncbi request reprint Thrombolytic treatment of acute ischemic stroke
    James F Meschia
    Department of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA
    Mayo Clin Proc 77:542-51. 2002
    ....
  27. ncbi request reprint New advances in identifying genetic anomalies in stroke-prone probands
    James F Meschia
    Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Curr Atheroscler Rep 5:317-23. 2003
    ..In the foreseeable future, prevention, diagnosis, and treatment will incorporate genetic data to refine and individualize management of cerebrovascular disease...
  28. pmc IL1RN VNTR polymorphism in ischemic stroke: analysis in 3 populations
    Bradford B Worrall
    Department of Neurology, University of Virginia Health System, Charlottesville, VA, USA
    Stroke 38:1189-96. 2007
    ..The purpose of this study was to confirm our earlier finding of an association between allele 2 of a variable number tandem repeat of the IL-1 receptor antagonist gene (IL1RN) and cerebrovascular disease...
  29. ncbi request reprint Aging blunts ischemic-preconditioning-induced neuroprotection following transient global ischemia in rats
    Zhen He
    Department of Pharmacology, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Curr Neurovasc Res 2:365-74. 2005
    ..05), suggesting that mechanisms of ischemic cell death may change with aging. In conclusion, aging alters mechanisms of ischemic cell death in CA1 neurons and ischemic tolerance mechanisms are blunted by aging...
  30. ncbi request reprint Addressing the heterogeneity of the ischemic stroke phenotype in human genetics research
    James F Meschia
    Department of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA
    Stroke 33:2770-4. 2002
    ..The purpose of this study was to review systematically the methods used to subtype ischemic stroke in recent genetic studies...
  31. ncbi request reprint Recombinant factor VIIa for rapid reversal of warfarin anticoagulation in acute intracranial hemorrhage
    William D Freeman
    Department of Neurology, Mayo Clinic College of Medicine, Jacksonville, Fla 32224, USA
    Mayo Clin Proc 79:1495-500. 2004
    ..To assess the effects of recombinant factor VIIa (rFVIIa) on hemorrhage volume and functional outcomes in warfarin-related acute intracranial hemorrhage (ICH), which has a 30-day mortality of more than 50%...
  32. pmc Sex differences in stroke evaluations in the Ischemic Stroke Genetics Study
    Thabele M Leslie-Mazwi
    Department of Neurology, Mayo Clinic, Jacksonville, Florida 32224, USA
    J Stroke Cerebrovasc Dis 16:187-93. 2007
    ..Sex differences in stroke evaluation could lead to sex differences in the validity of diagnosing ischemic stroke subtypes. This study assessed sex differences in the Ischemic Stroke Genetics Study (ISGS)...
  33. ncbi request reprint Paraneoplastic chorea associated with CRMP-5 neuronal antibody and lung carcinoma
    Steven Vernino
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Ann Neurol 51:625-30. 2002
    ..Four patients improved with chemotherapy, and 2 improved with intravenous methylprednisolone...
  34. pmc Joint Commission primary stroke center certification does not affect proband enrollment: the siblings with ischemic stroke study
    Alexa N Richie
    Department of Neurology, Mayo Clinic, Jacksonville, Florida 32224, USA
    J Stroke Cerebrovasc Dis 18:363-6. 2009
    ..Whether certification promotes enrollment of study subjects into stroke research studies is not known. We examined whether enrollment performance of centers was related to JC certification status...
  35. pmc Stenting versus endarterectomy for treatment of carotid-artery stenosis
    Thomas G Brott
    Mayo Clinic, Griffin 304, 4500 San Pablo Rd, Jacksonville, FL 32224, USA
    N Engl J Med 363:11-23. 2010
    ..Carotid-artery stenting and carotid endarterectomy are both options for treating carotid-artery stenosis, an important cause of stroke...
  36. ncbi request reprint Postprandial limb-shaking: an unusual presentation of transient cerebral ischemia
    William P Cheshire
    Dept of Neurology, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224, USA
    Clin Auton Res 16:243-6. 2006
    ..She was found to have profound postprandial hypotension, and the episodes were interpreted as an unusual transient ischemic attack...
  37. ncbi request reprint Aging is neuroprotective during global ischemia but leads to increased caspase-3 and apoptotic activity in hippocampal neurons
    Zhen He
    Department of Pharmacology, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Curr Neurovasc Res 3:181-6. 2006
    ..05). Aging appears to delay caspase-3-dependent apoptotic cell death induced by global ischemia in the CA1 region of the hippocampus, consistent with an age-induced neuroprotective process...
  38. doi request reprint Behavioral symptoms in long-term survivors of ischemic stroke
    Beth K Rush
    Division of Psychology, Mayo Clinic, Jacksonville, Florida 32224, USA
    J Stroke Cerebrovasc Dis 19:326-32. 2010
    ..Future research is needed to understand how the identification of behavioral symptoms after stroke can improve care in stroke survivors...
  39. doi request reprint Computer-assisted volumetric analysis compared with ABC/2 method for assessing warfarin-related intracranial hemorrhage volumes
    William D Freeman
    Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Neurocrit Care 9:307-12. 2008
    ..We compared 2 methods of measuring ICH volume in patients with warfarin-related ICH...
  40. doi request reprint Rapidly progressive primary central nervous system vasculitis
    Carlo Salvarani
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Rheumatology (Oxford) 50:349-58. 2011
    ..To describe a subset of cases in a large cohort of patients with primary CNS vasculitis (PCNSV) who appear to have a rapidly progressive clinical course...
  41. ncbi request reprint Hippocampal progenitor cells express nestin following cerebral ischemia in rats
    Zhen He
    Department of Pharmacology, Mayo Clinic Jacksonville, Jacksonville, Florida 32224, USA
    Neuroreport 16:1541-4. 2005
    ..eight-vessel occlusion, respectively). Confocal microscopy verified that a subset of the bromedeoxyuridine-positive cells expressed nestin. In conclusion, severe ischemia elicits nestin expression in hippocampal progenitor cells in rats...
  42. pmc A survey of the SWISS researchers on the impact of sibling privacy protections on pedigree recruitment
    Bradford B Worrall
    Department of Neurology, University of Virginia, Charlottesville, VA, USA
    Neuroepidemiology 25:32-41. 2005
    ..A substantial minority of researchers (37%) said the strategy impeded enrollment, and 44% said it was overly burdensome to probands...
  43. pmc LRRK2 variation and Parkinson's disease in African Americans
    Owen A Ross
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida 32224, USA
    Mov Disord 25:1973-6. 2010
    ..Given the ethnic-specific LRRK2 variation previously identified in PD further studies in under-represented populations are warranted...
  44. pmc Proband race/ethnicity affects pedigree completion rate in a genetic study of ischemic stroke
    Brett M Kissela
    Department of Neurology, University of Cincinnati, Cincinnati, Ohio, USA
    J Stroke Cerebrovasc Dis 17:299-302. 2008
    ..However, little is known about the predictors of enrollment in family-based observational genetic studies. We tested the hypothesis that proband race/ethnicity is a significant predictor of enrolling a pedigree...
  45. doi request reprint Acute ischemic stroke management: medical management
    Kevin M Barrett
    Department of Neurology, Mayo Clinic Florida, Jacksonville, Florida 32224, USA
    Semin Neurol 30:461-8. 2010
    ..External ultrasound as an adjunct to intravenous thrombolysis and treatment of those patients that wake up with stroke symptoms will also be discussed...
  46. doi request reprint Evaluation of subclinical cerebral injury and neuropsychologic function in patients undergoing carotid endarterectomy
    Juergen Falkensammer
    Section of Vascular Surgery, Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA
    Ann Vasc Surg 22:497-504. 2008
    ..This was the only individual to obtain a consistently high S100B and NSE increase. Neuropsychological testing combined with measurements of S100B and NSE may improve sensitivity when assessing subtle cerebral damage following CEA...
  47. ncbi request reprint Ischemic stroke as a complex genetic disorder
    James F Meschia
    Department of Neurology, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Semin Neurol 26:49-56. 2006
    ..Family history studies suggest that some subphenotypes like cardioembolic stroke may be less heritable than others...
  48. pmc Sex differences in stroke severity, symptoms, and deficits after first-ever ischemic stroke
    Kevin M Barrett
    Department of Neurology, Mayo Clinic, Jacksonville, Florida 32224, USA
    J Stroke Cerebrovasc Dis 16:34-9. 2007
    ..The purpose of the study was to assess whether there were sex differences in stroke severity, infarct characteristics, symptoms, or the symptoms-deficit relationship at the time of acute stroke presentation...
  49. pmc Stroke genetic research and adults with impaired decision-making capacity: a survey of IRB and investigator practices
    Donna T Chen
    Department of Neurology, Center for Biomedical Ethics and Humanities, University of Virginia, Charlottesville, VA 22908, USA
    Stroke 39:2732-5. 2008
    ..This study was conducted to obtain data on how investigators and IRBs handle surrogate authorization to enroll probands into a genetic study where some may lack capacity because of ischemic stroke...
  50. pmc Spouses and unrelated friends of probands as controls for stroke genetics studies
    Bradford Burke Worrall
    Department of Neurology, University of Virginia, Charlottesville, VA, USA
    Neuroepidemiology 22:239-44. 2003
    ..33%; p = 0.0002). Without proper attention to matching, the use of a spouse/friend convenience sample would result in imbalances in basic demographic characteristics...
  51. ncbi request reprint Genetics of cerebrovascular disorders
    James F Meschia
    Department of Neurology, Mayo Clinic College of Medicine, Jacksonville, Fla, USA
    Mayo Clin Proc 80:122-32. 2005
    ..This article reviews the clinical and genetic features of some mendellan and mitochondrial disorders associated with ischemic stroke, hemorrhagic stroke, and cerebrovascular malformations...
  52. ncbi request reprint Brain injury after cardiopulmonary arrest and its assessment with diffusion-weighted magnetic resonance imaging
    Kevin M Barrett
    Department of Neurology, College of Medicine, Mayo Clinic, Jacksonville, FL 32224, USA
    Mayo Clin Proc 82:828-35. 2007
    ....
  53. ncbi request reprint Choice of neuroimaging in perioperative acute stroke management
    Pablo R Castillo
    Department of Neurology, University of Minnesota, Minneapolis VA Medical Center, Minneapolis, MN, USA
    Neurol Clin 24:807-20. 2006
    ..Although MRI can provide more precise information, it is more time consuming and currently should be considered the method of choice for follow-up imaging, rather than initial imaging, in patients who have perioperative stroke...
  54. ncbi request reprint Creation of a bilingual Spanish-English version of the Questionnaire for Verifying Stroke-free Status
    Pablo R Castillo
    Division of Cardiovascular Diseases, Mayo Clinic, Jacksonville, FL 32224, USA
    Neuroepidemiology 23:236-9. 2004
    ..Blinded back-translation confirmed conceptual equivalence of the original English-language and final Spanish-language versions...
  55. doi request reprint Safety of recombinant activated factor VII in patients with warfarin-associated hemorrhages of the central nervous system
    Maisha T Robinson
    Department of Neurology, Mayo Clinic, Rochester, Minn 55905, USA
    Stroke 41:1459-63. 2010
    ..In this study, we assessed the risk of thromboembolic events in patients receiving recombinant Factor VIIa after ICH associated with warfarin treatment...
  56. ncbi request reprint Primary central nervous system vasculitis: analysis of 101 patients
    Carlo Salvarani
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Ann Neurol 62:442-51. 2007
    ..To analyze the clinical findings, response to therapy, outcome, and incidence of primary central nervous system vasculitis (PCNSV) in a large cohort from a single center...
  57. ncbi request reprint Contrasting the neurologic complications of cardiac transplantation in adults and children
    Thomas O Mayer
    Department of Neurology, Indiana University School of Medicine, Indianapolis 46202 5124, USA
    J Child Neurol 17:195-9. 2002
    ..However, peripheral neuropathies tend to occur more frequently in adults than in children (P = .04), and the types of complications in the immediate post-transplant period seem to differ...
  58. ncbi request reprint Genetics of ischemic stroke: inheritance of a sporadic disorder
    Owen A Ross
    Department of Neurology, Mayo Clinic Florida, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Curr Neurol Neurosci Rep 9:19-27. 2009
    ..Herein we discuss these genes and the potential role of genetics in the more common sporadic form of stroke and therapeutic intervention strategies...
  59. ncbi request reprint Editorial comment--Vascular thickness and calcification as markers of atherosclerotic burden
    James F Meschia
    Stroke 34:2372-3. 2003
  60. ncbi request reprint Genetics of vascular cognitive impairment: the opportunity and the challenges
    Gabrielle G Leblanc
    The Neurogenetics Group, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA
    Stroke 37:248-55. 2006
    ..This review considers the current state of knowledge of genetic factors underlying vascular cognitive impairment (VCI)...
  61. pmc A genome-wide genotyping study in patients with ischaemic stroke: initial analysis and data release
    Mar Matarin
    Molecular Genetics Unit, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Lancet Neurol 6:414-20. 2007
    ..We aimed to identify any common genetic variability exerting a moderate to large effect on risk of ischaemic stroke, and to generate publicly available genome-wide genotype data to facilitate others doing the same...
  62. ncbi request reprint Planning genetic studies and human stroke: sample size estimates based on family history data
    James F Meschia
    Neurology 59:1292. 2002
  63. ncbi request reprint High prevalence of stroke symptoms among persons without a diagnosis of stroke or transient ischemic attack in a general population: the REasons for Geographic And Racial Differences in Stroke (REGARDS) study
    Virginia J Howard
    Department of Epidemiology, University of Alabama at Birmingham School of Public Health, 1665 University Blvd, Birmingham, AL 35294 0022, USA
    Arch Intern Med 166:1952-8. 2006
    ..This study assessed the prevalence of stroke symptoms in a stroke- and transient ischemic attack (TIA)-free population and the association of symptoms with risk factors indexed by the Framingham Stroke Risk Score...
  64. doi request reprint Whole genome analyses suggest ischemic stroke and heart disease share an association with polymorphisms on chromosome 9p21
    Mar Matarin
    Stroke 39:1586-9. 2008
    ..Given that stroke is a common complication after myocardial infarction, we investigated if the same SNPs were associated with ischemic stroke in our population...
  65. pmc Impact of restricting enrollment in stroke genetics research to adults able to provide informed consent
    Donna T Chen
    Department of Public Health Sciences, University of Virginia Center for Biomedical Ethics, University of Virginia, Charlottesville, VA, USA
    Stroke 39:831-7. 2008
    ..The purpose of this study was to assess differences in stroke cohort characteristics between those who provided informed consent and those whose enrollment was authorized by surrogate decision makers...
  66. ncbi request reprint Characteristics of 100 consecutive patients presenting with orthostatic hypotension
    A Ahsan Ejaz
    Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Jacksonville, Fla, USA
    Mayo Clin Proc 79:890-4. 2004
    ..To elucidate the demographic and clinical characteristics of a consecutive series of patients who presented for evaluation of orthostatic hypotension...
  67. ncbi request reprint Defining stroke risks in sickle cell anemia
    James F Meschia
    Nat Genet 37:340-1. 2005
  68. ncbi request reprint Spanish cross-cultural adaptation and validation of the National Institutes of Health Stroke Scale
    Raúl Dominguez
    University of Buenos Aires Hospital Sirio Libanés, Instituto Médico ENERI, Ciudad Autónoma de Buenos Aire, Argentina
    Mayo Clin Proc 81:476-80. 2006
    ..To adapt and validate a Spanish-language version (SV) of the National Institutes of Health Stroke Scale (NIHSS) to facilitate its use in Spanish-speaking contexts...
  69. ncbi request reprint Lessons from adult stroke trials
    Steven G Pavlakis
    Mount Sinai School of Medicine, New York, New York, USA
    Pediatr Neurol 34:446-9. 2006
    ..Because clinical trials, more often than not, fail to give positive (effective treatment) results, it seems reasonable to attempt to learn from others' past experiences before initiating pediatric stroke trials...
  70. ncbi request reprint Genetics of stroke
    James F Meschia
    N Engl J Med 348:1407. 2003
  71. ncbi request reprint Stroke symptoms in individuals reporting no prior stroke or transient ischemic attack are associated with a decrease in indices of mental and physical functioning
    George Howard
    Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Stroke 38:2446-52. 2007
    ..Stroke symptoms in the absence of recognized stroke are common, but potential associated dysfunctions have not been described...
  72. pmc Association of integrin alpha2 gene variants with ischemic stroke
    Mar Matarin
    Neurogenetics Laboratory, National Institute on Aging, Bethesda, Maryland, USA
    J Cereb Blood Flow Metab 28:81-9. 2008
    ..These results provide additional support for a role for platelet receptor genes in the pathogenesis of ischemic stroke of diverse subtypes...
  73. ncbi request reprint Cardiac papillary fibroelastoma as a cause of recurrent ischemic strokes: the diagnostic value of serial transesophageal echocardiography
    Yasuhiko Baba
    Department of 5th Internal Medicine, Fukuoka University, Fukuoka, Japan
    Cerebrovasc Dis 14:256-9. 2002
  74. ncbi request reprint Ethics consultations and patients with neurological diseases
    Avi Algom
    Mayo Clin Proc 82:1577; author reply 1577-8. 2007
  75. ncbi request reprint Fragile vessels: handle with care
    James F Meschia
    Neurology 69:1560-1. 2007
  76. ncbi request reprint Familial hypercholesterolemia: stroke and the broader perspective
    James F Meschia
    Stroke 34:22-5. 2003

Research Grants16

  1. Siblings With Ischemic Stroke Study (SWISS)
    JAMES MESCHIA; Fiscal Year: 2009
    ..DNA banking and the creation of permanent lymphoblastoid cell lines will be done to permit future collaborative efforts to study the genetic basis for stroke risk. ..
  2. ISGS: The Ischemic Stroke Genetics Study
    JAMES MESCHIA; Fiscal Year: 2006
    ..The application and SWISS share the same definitions for the present and absence of phenotype and key enrollment criteria. ..
  3. MULTICENTERED STUDY OF STROKE GENETICS
    JAMES MESCHIA; Fiscal Year: 2004
    ..A centralized stroke verification committee will assure and accuracy in stroke phenotyping. DNA banking will be done to permitted future collaborative efforts to study the genetic basis for stroke risk. ..