L J Melton

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc What accounts for rib fractures in older adults?
    Lisa Ann Wuermser
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, College of Medicine, Rochester, MN 55905, USA
    J Osteoporos 2011:457591. 2011
  2. pmc Long-term mortality following fractures at different skeletal sites: a population-based cohort study
    L J Melton
    Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
    Osteoporos Int 24:1689-96. 2013
  3. pmc Fracture risk in women with breast cancer: a population-based study
    L Joseph Melton
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
    J Bone Miner Res 27:1196-205. 2012
  4. pmc Protocol for the Osteoporosis Choice trial. A pilot randomized trial of a decision aid in primary care practice
    Laurie J Pencille
    Knowledge and Encounter Research Unit, Mayo Clinic, Rochester, MN, USA
    Trials 10:113. 2009
  5. ncbi request reprint Effects of body size and skeletal site on the estimated prevalence of osteoporosis in women and men
    L J Melton
    Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Osteoporos Int 11:977-83. 2000
  6. ncbi request reprint Contributions of bone density and structure to fracture risk assessment in men and women
    L Joseph Melton
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Osteoporos Int 16:460-7. 2005
  7. ncbi request reprint Long-term fracture risk among women with proven endometriosis
    L Joseph Melton
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Fertil Steril 86:1576-83. 2006
  8. ncbi request reprint Long-Term fracture risk following ischemic stroke: a population-based study
    L J Melton
    Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Osteoporos Int 12:980-6. 2001
  9. pmc Relation of vertebral deformities to bone density, structure, and strength
    L Joseph Melton
    Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Bone Miner Res 25:1922-30. 2010
  10. pmc Trabecular bone deficits among Vietnamese immigrants
    L J Melton
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
    Osteoporos Int 22:1627-31. 2011

Detail Information

Publications139 found, 100 shown here

  1. pmc What accounts for rib fractures in older adults?
    Lisa Ann Wuermser
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, College of Medicine, Rochester, MN 55905, USA
    J Osteoporos 2011:457591. 2011
    ..Older women with rib fractures, regardless of cause, should be considered for an osteoporosis evaluation, and strategies to prevent falling should be considered in both sexes...
  2. pmc Long-term mortality following fractures at different skeletal sites: a population-based cohort study
    L J Melton
    Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
    Osteoporos Int 24:1689-96. 2013
    ..Adjusting for age, sex, and precipitating cause, the relative risk of death was increased following fractures at most skeletal sites...
  3. pmc Fracture risk in women with breast cancer: a population-based study
    L Joseph Melton
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
    J Bone Miner Res 27:1196-205. 2012
    ....
  4. pmc Protocol for the Osteoporosis Choice trial. A pilot randomized trial of a decision aid in primary care practice
    Laurie J Pencille
    Knowledge and Encounter Research Unit, Mayo Clinic, Rochester, MN, USA
    Trials 10:113. 2009
    ..e., absence of contamination) of patient-level randomization (vs. cluster randomization) in pilot trials of decision aid efficacy...
  5. ncbi request reprint Effects of body size and skeletal site on the estimated prevalence of osteoporosis in women and men
    L J Melton
    Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Osteoporos Int 11:977-83. 2000
    ..These observations emphasize the difficulties involved in attempts to standardize BMD scores and definitions of osteoporosis for clinical use...
  6. ncbi request reprint Contributions of bone density and structure to fracture risk assessment in men and women
    L Joseph Melton
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Osteoporos Int 16:460-7. 2005
    ..Because of the strong correlations, however, some judgment can be used in selecting the variables easiest to measure...
  7. ncbi request reprint Long-term fracture risk among women with proven endometriosis
    L Joseph Melton
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Fertil Steril 86:1576-83. 2006
    ..To determine whether women with pelvic endometriosis are at increased fracture risk...
  8. ncbi request reprint Long-Term fracture risk following ischemic stroke: a population-based study
    L J Melton
    Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Osteoporos Int 12:980-6. 2001
    ..Patients and their caretakers need to be aware of the risk of fracture from falls, particularly when moderate impairment permits the patient to be independently mobile...
  9. pmc Relation of vertebral deformities to bone density, structure, and strength
    L Joseph Melton
    Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Bone Miner Res 25:1922-30. 2010
    ..Thus significantly impaired bone density, structure, and strength compared with controls indicate that many grade 1 deformities do represent early osteoporotic fractures, with corresponding implications for clinical decision making...
  10. pmc Trabecular bone deficits among Vietnamese immigrants
    L J Melton
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
    Osteoporos Int 22:1627-31. 2011
    ....
  11. pmc Assessing forearm fracture risk in postmenopausal women
    L J Melton
    Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
    Osteoporos Int 21:1161-9. 2010
    ....
  12. pmc A bone structural basis for fracture risk in diabetes
    L Joseph Melton
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First Street Southwest, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 93:4804-9. 2008
    ..Elevated areal bone mineral density (aBMD) in type 2 diabetes mellitus is inconsistent with increased fracture risk at some skeletal sites...
  13. ncbi request reprint Epidemiology of vertebral fractures: implications for vertebral augmentation
    L Joseph Melton
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, MN 55905, USA
    Acad Radiol 13:538-45. 2006
    ..Vertebral augmentation may be able to help many of these patients, although opportunities exist to optimize management strategies with respect to the other factors that influence long-term outcomes in this patient population...
  14. pmc Secular trends in hip fracture incidence and recurrence
    L J Melton
    Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Osteoporos Int 20:687-94. 2009
    ..The decline in hip fracture incidence is now accompanied by a further reduction in the likelihood of a recurrent hip fracture among survivors of the first fracture...
  15. pmc Determinants of forearm strength in postmenopausal women
    L J Melton
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
    Osteoporos Int 22:3047-54. 2011
    ..The specific formula for this bone strength surrogate (-555.2 + 8.1 × [trabecular vBMD] + 19.6 × [cortical area] + 4.2 × [total cross-sectional area]) should be validated and tested in fracture risk assessment...
  16. ncbi request reprint Influence of baseline deformity definition on subsequent vertebral fracture risk in postmenopausal women
    L J Melton
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First Street S W, Rochester, MN 55905, USA
    Osteoporos Int 17:978-85. 2006
    ..Approaches for recognizing vertebral fractures remain controversial...
  17. ncbi request reprint Cost-equivalence of different osteoporotic fractures
    L J Melton
    Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Osteoporos Int 14:383-8. 2003
    ....
  18. pmc Influence of hysterectomy on long-term fracture risk
    L Joseph Melton
    Division of Epidemiology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Fertil Steril 88:156-62. 2007
    ..To assess long-term fracture risk after hysterectomy, with or without oophorectomy...
  19. pmc Disease associations with monoclonal gammopathy of undetermined significance: a population-based study of 17,398 patients
    John P Bida
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 84:685-93. 2009
    ..To systematically study the association of monoclonal gammopathy of undetermined significance (MGUS) with all diseases in a population-based cohort of 17,398 patients, all of whom were uniformly tested for the presence or absence of MGUS...
  20. ncbi request reprint Increased risk of cognitive impairment or dementia in women who underwent oophorectomy before menopause
    W A Rocca
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 69:1074-83. 2007
    ..We studied the association of oophorectomy performed before the onset of menopause with the risk of subsequent cognitive impairment or dementia...
  21. ncbi request reprint Predictors of recurrence after deep vein thrombosis and pulmonary embolism: a population-based cohort study
    J A Heit
    Division of Cardiovascular Diseases, Mayo Clinic and Mayo Foundation, Rochester, Minn 55905, USA
    Arch Intern Med 160:761-8. 2000
    ..The appropriate duration of oral anticoagulation after a first episode of venous thromboembolism (VTE) is uncertain and depends upon VTE recurrence rates...
  22. ncbi request reprint Bone density in an immigrant population from Southeast Asia
    M A Marquez
    Office of Diversity in Clinical Research, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Osteoporos Int 12:595-604. 2001
    ..These findings indicate a need for culturally sensitive educational interventions for Southeast Asians and for physicians to pursue diagnosis and treatment to prevent osteoporosis-related disabilities in this population...
  23. ncbi request reprint Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: a key role for bioavailable estrogen
    S Khosla
    Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 83:2266-74. 1998
    ..These studies suggest that in contrast to traditional belief, age-related bone loss may be the result of E deficiency not just in postmenopausal women, but also in men...
  24. ncbi request reprint Incidence of venous thromboembolism in hospitalized patients vs community residents
    J A Heit
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 76:1102-10. 2001
    ..This finding emphasizes the need for accurate identification of hospitalized patients at risk for venous thromboembolism and a better understanding of the mechanisms involved so that safe and effective prophylaxis can be implemented...
  25. ncbi request reprint Relationship of serum sex steroid levels to longitudinal changes in bone density in young versus elderly men
    S Khosla
    Endocrine Research Unit, Division of Endocrinology, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 86:3555-61. 2001
    ..This subset of men is perhaps most likely to benefit from preventive therapy...
  26. ncbi request reprint The epidemiology of venous thromboembolism in the community
    J A Heit
    Division of Cardiovascular Diseases, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Thromb Haemost 86:452-63. 2001
    ..To reduce venous thromboembolism incidence, improve survival, and prevent recurrence and complications, patients with these characteristics should receive appropriate prophylaxis...
  27. pmc Use of renal function measurements for assessing fracture risk in postmenopausal women
    James T McCarthy
    Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 83:1231-9. 2008
    ....
  28. ncbi request reprint Obesity is associated with increased risk of gastrointestinal symptoms: a population-based study
    Silvia Delgado-Aros
    Clinical Enteric Neuroscience Translational and Epidemiological Research C E N T E R Program, Mayo Clinic Rochester, 200 First Street SW, Rochester, MN 55905, USA
    Am J Gastroenterol 99:1801-6. 2004
    ..Alternatively, excess food intake may cause gastrointestinal (GI) symptoms in obese patients. We evaluated the relationship between body mass index (BMI) and specific GI symptoms in the community...
  29. pmc Morbidity and mortality among older individuals with undiagnosed celiac disease
    Jonathan D Godfrey
    Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Gastroenterology 139:763-9. 2010
    ..Outcomes of undiagnosed celiac disease (CD) are unclear. We evaluated the morbidity and mortality of undiagnosed CD in a population-based sample of individuals 50 years of age and older...
  30. pmc Mortality in the vertebroplasty population
    R J McDonald
    Clinician Investigator Training Program, Department of Radiology, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    AJNR Am J Neuroradiol 32:1818-23. 2011
    ....
  31. ncbi request reprint Estrogens and bone health in men
    S Khosla
    Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Calcif Tissue Int 69:189-92. 2001
    ..Collectively then, these findings indicate that estrogen plays a dominant role in regulating the male skeleton...
  32. pmc Comparison of sex steroid measurements in men by immunoassay versus mass spectroscopy and relationships with cortical and trabecular volumetric bone mineral density
    S Khosla
    Endocrine Research Unit, Division of Rheumatology, Department of Laboratory Medicine, and Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Osteoporos Int 19:1465-71. 2008
    ..In men, measurement of serum testosterone and estradiol levels with immunoassays correlated with mass spectroscopic measurements, and correlations of sex steroids with volumetric bone mineral density were similar...
  33. ncbi request reprint Trends in persistent proteinuria in adult-onset diabetes: a population-based study
    T S Larson
    Division of Nephrology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Diabetes Care 23:51-6. 2000
    ..This study investigates temporal trends in the prevalence and incidence of persistent proteinuria among people with adult-onset diabetes (age > or =40 years)...
  34. ncbi request reprint Functional gastrointestinal disorders among people with sleep disturbances: a population-based study
    Santhi Swaroop Vege
    Division of General Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Mayo Clin Proc 79:1501-6. 2004
    ..To determine whether unexplained gastrointestinal (GI) symptoms are more common in people with self-reported sleep disturbance...
  35. ncbi request reprint Changing trends in the incidence, stage, survival, and screen-detection of colorectal cancer: a population-based study
    Amit K Gupta
    Division of General Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA
    Clin Gastroenterol Hepatol 3:150-8. 2005
    ..This study assessed concurrent trends in CRC incidence, presentation, survival, mortality, and polypectomies in Olmsted County, Minnesota...
  36. ncbi request reprint Risk factors for deep vein thrombosis and pulmonary embolism: a population-based case-control study
    J A Heit
    Division of Cardiovascular Diseases, Mayo Clinic and Mayo Foundation, Rochester, Minn 55905, USA
    Arch Intern Med 160:809-15. 2000
    ..Reported risk factors for venous thromboembolism (VTE) vary widely, and the magnitude and independence of each are uncertain...
  37. ncbi request reprint Temporal trends in BMI among adults with diabetes
    C L Leibson
    Department of Health Sciences Research, Mayo Clinic Foundation, 200 First St SW, Rochester, MN 55905, USA
    Diabetes Care 24:1584-9. 2001
    ..Increasing obesity within the general population has been accompanied by rising rates of diabetes. The extent to which obesity has increased among people with diabetes is unknown, as are the potential consequences for diabetes outcomes...
  38. ncbi request reprint Direct medical costs attributable to osteoporotic fractures
    S E Gabriel
    Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA
    Osteoporos Int 13:323-30. 2002
    ..The use of incremental costs in economic analyses will provide a more accurate reflection of the true cost-effectiveness of osteoporosis prevention...
  39. ncbi request reprint Fracture risk in monoclonal gammopathy of undetermined significance
    L Joseph Melton
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    J Bone Miner Res 19:25-30. 2004
    ..There was a 2.7-fold increase in the risk of axial fractures but no increase in limb fractures. The pathophysiologic basis for the increased axial fractures should be determined...
  40. ncbi request reprint Incidence of a clinical diagnosis of the irritable bowel syndrome in a United States population
    G R Locke
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Aliment Pharmacol Ther 19:1025-31. 2004
    ..The incidence of irritable bowel syndrome is uncertain. We aimed to determine the incidence of clinically diagnosed irritable bowel syndrome in the community...
  41. ncbi request reprint Long-term effects of calcium supplementation on serum parathyroid hormone level, bone turnover, and bone loss in elderly women
    B L Riggs
    Division of Endocrinology and Metabolism, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    J Bone Miner Res 13:168-74. 1998
    ..Nonetheless, because of their safety, high tolerance, and low expense, calcium supplements may be a useful preventive measure for elderly postmenopausal women whose bone mineral density values are normal for their age...
  42. ncbi request reprint Correlates of osteoprotegerin levels in women and men
    S Khosla
    Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Osteoporos Int 13:394-9. 2002
    ..Further studies directly testing these hypotheses should provide additional insights into the potential role of OPG in bone loss related to aging and sex steroid deficiency...
  43. pmc Is diabetes mellitus an independent risk factor for venous thromboembolism?: a population-based case-control study
    John A Heit
    Division of Cardiovascular Diseases, Section of Vascular Diseases, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Arterioscler Thromb Vasc Biol 29:1399-405. 2009
    ..Consequently, we tested diabetes for an independent association with incident VTE...
  44. ncbi request reprint Secondary osteoporosis and the risk of distal forearm fractures in men and women
    L J Melton
    Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Bone 31:119-25. 2002
    ..These factors do not appear to account for the discrepancy in forearm fracture incidence in women when compared with men...
  45. pmc Suppression of uninvolved immunoglobulins defined by heavy/light chain pair suppression is a risk factor for progression of MGUS
    J A Katzmann
    Division of Clinical Biochemistry and Immunology, Department of Laboratory Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Leukemia 27:208-12. 2013
    ..8; 95% CI, 1.1-3.00; P=0.018). The finding that HLC-pair suppression predicts progression in MGUS and occurs several years before malignant transformation has implications for myeloma biology...
  46. pmc Relationship of femoral neck areal bone mineral density to volumetric bone mineral density, bone size, and femoral strength in men and women
    B Srinivasan
    Endocrine Research Unit, Mayo Clinic, Guggenheim 7, 200 First Street SW, Rochester, MN 55905, USA
    Osteoporos Int 23:155-62. 2012
    ....
  47. ncbi request reprint Decline in bilateral orchiectomy for prostate cancer in Olmsted county, Minnesota, 1956-2000
    L J Melton
    Department of Health Sciences Research, Mayo Clinic, Rochester, Minn. 55902, USA
    Mayo Clin Proc 76:1199-203. 2001
    ....
  48. ncbi request reprint Trends in the incidence of venous stasis syndrome and venous ulcer: a 25-year population-based study
    J A Heit
    Division of Cardiovascular Diseases, Section of Vascular Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    J Vasc Surg 33:1022-7. 2001
    ..The incidence rates of venous stasis syndrome and venous ulcer are uncertain, and trends in incidence are unknown...
  49. pmc Long-term trends in carpal tunnel syndrome
    R Gelfman
    Department of Physical Medicine and Rehabilitation, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 72:33-41. 2009
    ..To assess temporal trends in carpal tunnel syndrome (CTS) incidence, surgical treatment, and work-related lost time...
  50. ncbi request reprint Epidemiology and natural history of primary biliary cirrhosis in a US community
    W R Kim
    Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Gastroenterology 119:1631-6. 2000
    ..We report the incidence and prevalence of this condition in the general population. We also examined the validity of the Mayo natural history model for PBC among these unselected patients from the community...
  51. ncbi request reprint Long-term survival of patients with anorexia nervosa: a population-based study in Rochester, Minn
    Sergio R Korndörfer
    Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minn 55905, USA
    Mayo Clin Proc 78:278-84. 2003
    ..To estimate long-term survival of unselected patients with anorexia nervosa from Rochester, Minn...
  52. pmc Increased cardiovascular mortality after early bilateral oophorectomy
    Cathleen M Rivera
    Division of Preventive and Occupational Medicine, Department of Internal Medicine, College of Medicine, Mayo Clinic, Rochester, MN, USA
    Menopause 16:15-23. 2009
    ..To investigate the mortality associated with cardiovascular diseases and the effect of estrogen treatment in women who underwent unilateral or bilateral oophorectomy before menopause...
  53. pmc A population-based assessment of rates of bone loss at multiple skeletal sites: evidence for substantial trabecular bone loss in young adult women and men
    B Lawrence Riggs
    Endocrine Research Unit, Division of Endocrinology and Metabolism, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    J Bone Miner Res 23:205-14. 2008
    ..Cortical bone loss began in perimenopause in women and later in life in men. In contrast, trabecular bone loss began in young adulthood in both sexes...
  54. ncbi request reprint Overlap of gastrointestinal symptom complexes in a US community
    G R Locke
    Division of Gastroenterology and Internal Medicine, and Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Neurogastroenterol Motil 17:29-34. 2005
    ..In addition, therapies may be effective in subsets of people with specific disorders, yet at the same time help people with multiple disorders...
  55. ncbi request reprint Long-term fracture risk among infertile women: a population-based cohort study
    L J Melton
    Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, MN 55905, USA
    J Womens Health Gend Based Med 10:289-97. 2001
    ....
  56. ncbi request reprint Role of serum leptin, insulin, and estrogen levels as potential mediators of the relationship between fat mass and bone mineral density in men versus women
    T Thomas
    Endocrine Research Unit, Division of Endocrinology, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Bone 29:114-20. 2001
    ..In women, leptin may also mediate at least part of the protective effect of fat mass on the skeleton...
  57. ncbi request reprint The prevalence of osteoporosis: gender and racial comparison
    L J Melton
    Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Calcif Tissue Int 69:179-81. 2001
    ..These observations reinforce current efforts to move away from osteoporosis prevalence and toward absolute fracture risk as the main basis for clinical treatment decisions...
  58. pmc Incidence and prevalence of CIDP and the association of diabetes mellitus
    R S Laughlin
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 73:39-45. 2009
    ..9 to 7.7 per 100,000. CIDP is reported to occur more commonly in patients with diabetes mellitus (DM) but has not been rigorously tested...
  59. ncbi request reprint Age-related lobular involution and risk of breast cancer
    Tia R Milanese
    Mayo Medical School, Rochester, MN 55905, USA
    J Natl Cancer Inst 98:1600-7. 2006
    ..As women age, the lobules in their breasts undergo involution or regression. We investigated whether lobular involution in women with benign breast disease was associated with subsequent breast cancer risk...
  60. pmc Predictors of family risk for celiac disease: a population-based study
    Alberto Rubio-Tapia
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Clin Gastroenterol Hepatol 6:983-7. 2008
    ..Our aim was to determine the clinical, serologic, and genetic predictors of CD in FMs of a population-based cohort of index cases...
  61. ncbi request reprint Trends in the incidence of venous thromboembolism during pregnancy or postpartum: a 30-year population-based study
    John A Heit
    Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann Intern Med 143:697-706. 2005
    ..The risk for venous thromboembolism during pregnancy or postpartum is uncertain...
  62. ncbi request reprint Osteoporosis assessment by whole body region vs. site-specific DXA
    L Joseph Melton
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street S W, Rochester, MN 55905, USA
    Osteoporos Int 16:1558-64. 2005
    ....
  63. ncbi request reprint Relative impact of risk factors for deep vein thrombosis and pulmonary embolism: a population-based study
    John A Heit
    Hematology Research, Stabile 660, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Arch Intern Med 162:1245-8. 2002
    ....
  64. ncbi request reprint Relative contributions of bone density, bone turnover, and clinical risk factors to long-term fracture prediction
    L Joseph Melton
    Division of Epidemiology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    J Bone Miner Res 18:312-8. 2003
    ..Identifying patients at increased long-term risk of fracture is challenging, but it is reassuring that femoral neck bone mineral density can predict osteoporotic fractures up to 20 years later...
  65. ncbi request reprint Evaluation of a prediction model for long-term fracture risk
    L Joseph Melton
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Bone Miner Res 20:551-6. 2005
    ..The NOF cost-effectiveness model, based on clinical risk factors and femoral neck aBMD, predicted overall fracture risk in a cohort of postmenopausal women followed for up to 22 years...
  66. ncbi request reprint Role of low levels of endogenous estrogen in regulation of bone resorption in late postmenopausal women
    Hassan M Heshmati
    Division of Endocrinology and Metabolism, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    J Bone Miner Res 17:172-8. 2002
    ....
  67. pmc Trends in subtrochanteric, diaphyseal, and distal femur fractures, 1984-2007
    A C Ng
    Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Medicine, College of Medicine, Mayo Clinic, Rochester, MN, USA
    Osteoporos Int 23:1721-6. 2012
    ..The incidence of non-hip femur fractures increased between 1984 and 2007, with an increase in the rates for women after 1996...
  68. ncbi request reprint Is early colonoscopy after admission for acute diverticular bleeding needed?
    Rory L Smoot
    Mayo Medical School, Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, Minnesota, USA
    Am J Gastroenterol 98:1996-9. 2003
    ..This study evaluated the association between timing of colonoscopy and diagnostic yield in patients admitted with acute colonic diverticular bleeding...
  69. ncbi request reprint Epidemiology of spinal osteoporosis
    L J Melton
    Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA
    Spine (Phila Pa 1976) 22:2S-11S. 1997
    ..However, they have a substantial negative impact on the patient's function and quality of life. The adverse effects of osteoporotic fractures are likely to increase in the future with the growing number of elderly people...
  70. ncbi request reprint Potential for bone turnover markers to cost-effectively identify and select post-menopausal osteopenic women at high risk of fracture for bisphosphonate therapy
    J T Schousboe
    Division of Health Services Research and Policy, School of Public Health, University of Minnesota, Minneapolis, MN, USA
    Osteoporos Int 18:201-10. 2007
    ..Measurement of bone turnover may cost-effectively identify a subset of women with T-score >-2.5 for whom anti-resorptive drug therapy is cost-effective...
  71. ncbi request reprint Increased risk of parkinsonism in women who underwent oophorectomy before menopause
    W A Rocca
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Neurology 70:200-9. 2008
    ..We studied the association of oophorectomy performed before the onset of menopause with the risk of subsequent parkinsonism...
  72. ncbi request reprint Effects of changing diagnostic criteria on the risk of developing diabetes
    S F Dinneen
    Division of Endocrinology and Metabolism, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Diabetes Care 21:1408-13. 1998
    ..8 mmol/l (the level recommended by the National Diabetes Data Group [NDDG] in 1979) to 7.0 mmol/l. We examined the impact of this change on rates of progression to overt diabetes from different levels of FPG...
  73. ncbi request reprint Fracture risk with multiple myeloma: a population-based study
    L Joseph Melton
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Bone Miner Res 20:487-93. 2005
    ..Pathologic fractures, especially of the axial skeleton, are extremely common in patients with multiple myeloma and cluster around the time of diagnosis. Osteoporotic fractures seem to be less of a problem in these patients...
  74. ncbi request reprint Fracture risk after the diagnosis of Parkinson's disease: Influence of concomitant dementia
    L Joseph Melton
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Mov Disord 21:1361-7. 2006
    ..1). The increased fracture risk in patients with PD is not entirely explained by concomitant dementia, and additional study is needed to determine the relative contributions to fracture risk of falls versus bone loss in these patients...
  75. ncbi request reprint Does reduced skeletal loading account for age-related bone loss?
    L Joseph Melton
    Division of Epidemiology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Bone Miner Res 21:1847-55. 2006
    ..However, in a population-based study of 375 women and 325 men (age, 21-97 years), we failed to find a close correspondence between these variables and changes in bone strength with aging...
  76. pmc Fracture risk in type 2 diabetes: update of a population-based study
    L Joseph Melton
    Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA
    J Bone Miner Res 23:1334-42. 2008
    ....
  77. ncbi request reprint Long-term fracture risk following adult-onset asthma: a population-based study
    L Joseph Melton
    Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street S W, Rochester, MN 55905, USA
    Osteoporos Int 15:311-6. 2004
    ....
  78. ncbi request reprint Natural history of functional gastrointestinal disorders: a 12-year longitudinal population-based study
    Smita L S Halder
    Dyspepsia Center, Enteric Neuroscience Program, Division of Gastroenterology and Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Gastroenterology 133:799-807. 2007
    ..The natural history of FGID is unknown because of a lack of prospective population-based studies and the indistinct nature of the phenotype. We sought to report the natural history of FGID in a US population...
  79. pmc Prognostic value of the serum free light chain ratio in newly diagnosed myeloma: proposed incorporation into the international staging system
    C L H Snozek
    Department of Laboratory Medicine and Pathology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Leukemia 22:1933-7. 2008
    ..001). These findings suggest that the serum FLC ratio at initial diagnosis is an important predictor of prognosis in myeloma, and can be incorporated into the ISS for improved risk stratification...
  80. ncbi request reprint Long-term survival among patients operated upon for peptic ulcer disease
    J M Duggan
    Department of Health Sciences Research, Mayo Clinic Rochester, Minnesota 55905, USA
    J Gastroenterol Hepatol 14:1074-82. 1999
    ..Our aim was to compare long-term survival in a large, population-based cohort of operated patients with that expected in the general population...
  81. ncbi request reprint Alternating bowel pattern: what do people mean?
    R S Choung
    Dyspepsia Center and Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN, USA
    Aliment Pharmacol Ther 23:1749-55. 2006
    ..With the introduction of new therapies, the subgrouping of patients based on bowel pattern has become important. However, the appropriate definition of an alternating bowel pattern remains unclear...
  82. pmc Increased prevalence and mortality in undiagnosed celiac disease
    Alberto Rubio-Tapia
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Gastroenterology 137:88-93. 2009
    ..The historical prevalence and long-term outcome of undiagnosed celiac disease (CD) are unknown. We investigated the long-term outcome of undiagnosed CD and whether the prevalence of undiagnosed CD has changed during the past 50 years...
  83. pmc HLA DQ gene dosage and risk and severity of celiac disease
    Joseph A Murray
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Clin Gastroenterol Hepatol 5:1406-12. 2007
    ..The aim of this study was to examine the role of DQA and DQB alleles in determining the risk for and the age of onset and severity of CD in an American population...
  84. pmc Robust QCT/FEA models of proximal femur stiffness and fracture load during a sideways fall on the hip
    Dan Dragomir-Daescu
    Division of Engineering, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Ann Biomed Eng 39:742-55. 2011
    ..The predicted stiffness (cross-validation R (2) = 0.87), fracture load (cross-validation R (2) = 0.85), and fracture patterns (83% agreement) correlated well with experimental data...
  85. pmc Long-term effects of bilateral oophorectomy on brain aging: unanswered questions from the Mayo Clinic Cohort Study of Oophorectomy and Aging
    Walter A Rocca
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Womens Health (Lond Engl) 5:39-48. 2009
    ..Results from other studies are cited as evidence for or against each possible mechanism. These putative causal mechanisms are probably intertwined, and their clarification is a research priority...
  86. pmc Impact of venous thromboembolism, venous stasis syndrome, venous outflow obstruction and venous valvular incompetence on quality of life and activities of daily living: a nested case-control study
    Aneel A Ashrani
    Division of Hematology, Department of Internal Medicine, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Vasc Med 15:387-97. 2010
    ..VOO and VTE are associated with impaired ADL. We hypothesize that rapid clearance of venous outflow obstruction in individuals with acute VTE will improve their QoL and ADL...
  87. pmc Bowel disturbances are the most important risk factors for late onset fecal incontinence: a population-based case-control study in women
    Adil E Bharucha
    Clinical and Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Clinic, Rochester, Minnesota 55905, USA
    Gastroenterology 139:1559-66. 2010
    ..However, the contribution of obstetric injury to the development of FI later in life is unclear. We sought to better understand the risk factors for FI...
  88. ncbi request reprint Clinical review 144: Estrogen and the male skeleton
    Sundeep Khosla
    Endocrine Research Unit, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 87:1443-50. 2002
    ....
  89. pmc Effects of sex and age on bone microstructure at the ultradistal radius: a population-based noninvasive in vivo assessment
    Sundeep Khosla
    Endocrine Research Unit, Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Bone Miner Res 21:124-31. 2006
    ..Compared with women, men had thicker trabeculae in young adulthood and had less microstructural damage with aging. These findings may contribute to the virtual immunity of men to age-related increases in wrist fractures...
  90. ncbi request reprint Evidence that type I osteoporosis results from enhanced responsiveness of bone to estrogen deficiency
    B Lawrence Riggs
    Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, 200 First Street SW, MN 55905, Rochester, USA
    Osteoporos Int 14:728-33. 2003
    ..This is consistent with the hypothesis that the greater bone loss in type I osteoporosis is the result of impaired responsiveness of bone to low postmenopausal levels of sex steroids...
  91. ncbi request reprint Trends in the mortality burden associated with diabetes mellitus: a population-based study in Rochester, Minn, 1970-1994
    Randal J Thomas
    Department of Medicine, Mayo Clinic and Foundation, 200 First St SW, Rochester, MN 55905, USA
    Arch Intern Med 163:445-51. 2003
    ..The prevalence of diabetes mellitus (DM) has increased markedly in recent decades, but trends in the mortality burden associated with DM are unclear. Therefore, we analyzed population-based longitudinal data to address this issue...
  92. pmc Prevalence and risk of progression of light-chain monoclonal gammopathy of undetermined significance: a retrospective population-based cohort study
    Angela Dispenzieri
    Hematology, Mayo Clinic, Rochester, MN 55905, USA
    Lancet 375:1721-8. 2010
    ..The remaining 20% are characterised by absence of IgH expression; we aimed to assess prevalence of a corresponding precursor entity, light-chain MGUS...
  93. ncbi request reprint The epidemiology of primary hyperparathyroidism in North America
    L Joseph Melton
    Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    J Bone Miner Res 17:N12-7. 2002
    ..Better data on the disability and costs related to HPT and its treatment will be needed to devise the most efficient approaches to patient management...
  94. pmc Kidney stones and the risk for chronic kidney disease
    Andrew D Rule
    Departments of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota 55905
    Clin J Am Soc Nephrol 4:804-11. 2009
    ..Kidney stones lead to chronic kidney disease (CKD) in people with rare hereditary disorders (e.g., primary hyperoxaluria, cystinuria), but it is unknown whether kidney stones are an important risk factor for CKD in the general population...
  95. pmc Incidence and clinical spectrum of thiazide-associated hypercalcemia
    Robert A Wermers
    Division of Endocrinology, Department of Medicine, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Am J Med 120:911.e9-15. 2007
    ..The study determines the incidence of thiazide-associated hypercalcemia and clarifies its clinical features and natural history...
  96. ncbi request reprint Trends in the identification and clinical features of celiac disease in a North American community, 1950-2001
    Joseph A Murray
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Clin Gastroenterol Hepatol 1:19-27. 2003
    ..This study reports temporal trends in the incidence of celiac disease in Olmsted County, Minnesota...
  97. ncbi request reprint Long-term trends in thyroid carcinoma: a population-based study in Olmsted County, Minnesota, 1935-1999
    James P Burke
    Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Mayo Clin Proc 80:753-8. 2005
    ....
  98. ncbi request reprint Mortality and hospital utilization for hepatocellular carcinoma in the United States
    W Ray Kim
    Division of Gastroenterology and Hepatology and Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Gastroenterology 129:486-93. 2005
    ..Hospital service utilization was estimated based on length of stay, total hospitalization charges, and principal procedures...
  99. ncbi request reprint Presence of monoclonal free light chains in the serum predicts risk of progression in monoclonal gammopathy of undetermined significance
    S Vincent Rajkumar
    Division of Hematology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Br J Haematol 127:308-10. 2004
    ..The presence of an abnormal kappa/lambda FLC ratio in the serum was associated with a higher risk of MGUS progression (relative risk 2.5; 95% confidence interval: 1.6-4.0; P < 0.001)...
  100. ncbi request reprint Population-based analysis of the relationship of whole bone strength indices and fall-related loads to age- and sex-specific patterns of hip and wrist fractures
    B Lawrence Riggs
    Endocrine Research Unit, Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Bone Miner Res 21:315-23. 2006
    ..These load/strength ratios more closely simulated patterns of wrist and hip fractures occurring in the same population than did measurement of vBMD...