H L Melrose

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors
    Kelly M Hinkle
    Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224, USA
    Mol Neurodegener 7:25. 2012
  2. pmc ER stress response plays an important role in aggregation of α-synuclein
    Peizhou Jiang
    Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, Florida 32224, USA
    Mol Neurodegener 5:56. 2010
  3. pmc In vivo silencing of alpha-synuclein using naked siRNA
    Jada Lewis
    Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Mol Neurodegener 3:19. 2008
  4. ncbi request reprint Anatomical localization of leucine-rich repeat kinase 2 in mouse brain
    H Melrose
    Department of Neuroscience, Genetics of Parkinsonism and Related Disorders, Morris K Udall Parkinson s Disease Research Center of Excellence, Birdsall Building, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Neuroscience 139:791-4. 2006
  5. ncbi request reprint A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease
    H L Melrose
    Molecular Genetics Laboratory and Core, Morris K Udall Parkinson s Disease Research Center of Excellence, Mayo Clinic, Department of Neuroscience, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Neuroscience 147:1047-58. 2007
  6. pmc Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice
    H L Melrose
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
    Neurobiol Dis 40:503-17. 2010

Collaborators

  • J G Culvenor
  • M Boules
  • S Lincoln
  • Z K Wszolek
  • C Janus
  • DENNIS WILLIAM DICKSON
  • O A Ross
  • Matthew James Farrer
  • Kelly M Hinkle
  • Wen Lang Lin
  • Peizhou Jiang
  • Jada Lewis
  • Justus C Dachsel
  • Caroline B Kent
  • Mei Yue
  • Kenya Nishioka
  • Bahareh Behrouz
  • Joel E Beevers
  • Iryna Prots
  • Erin E Bowles
  • Brittany Dugger
  • Beate Winner
  • Abdul Shukkur Ebrahim
  • Shu Hui C Yen
  • Ming Gan
  • Ravi Braich
  • Zhen He
  • Demetrius M Maraganore
  • Kelly Hinkle
  • Sina Ogholikhan
  • Cynthia Zehr
  • Michael Heckman
  • David Bumcrot
  • Adam Braithwaite
  • Klaus Charisse
  • Rajendra K Pandey
  • Andrew Hope
  • Julia Crook
  • Ivanka Toudjarska
  • Caroline Kent

Detail Information

Publications6

  1. pmc LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors
    Kelly M Hinkle
    Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224, USA
    Mol Neurodegener 7:25. 2012
    ..Finally, we confirm that loss of LRRK2 caused degeneration in the kidney, accompanied by a progressive enhancement of autophagic activity and accumulation of autofluorescent material, but without evidence of biphasic changes...
  2. pmc ER stress response plays an important role in aggregation of α-synuclein
    Peizhou Jiang
    Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, Florida 32224, USA
    Mol Neurodegener 5:56. 2010
    ..These drugs have been demonstrated to protect cells transiently overexpressing α-synuclein from its toxicity...
  3. pmc In vivo silencing of alpha-synuclein using naked siRNA
    Jada Lewis
    Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Mol Neurodegener 3:19. 2008
    ..Genetic variability in SNCA contributes to risk of idiopathic Parkinson's disease (PD), possibly as a result of overexpression. SNCA downregulation is therefore a valid therapeutic target for PD...
  4. ncbi request reprint Anatomical localization of leucine-rich repeat kinase 2 in mouse brain
    H Melrose
    Department of Neuroscience, Genetics of Parkinsonism and Related Disorders, Morris K Udall Parkinson s Disease Research Center of Excellence, Birdsall Building, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Neuroscience 139:791-4. 2006
    ..Consistent with a role LRRK2 in Parkinson's disease, dysfunction of leucine-rich repeat kinase 2 protein in dopamine-innervated areas may to lead to altered dopaminergic neurotransmission and degeneration of the nigro-striatal pathway...
  5. ncbi request reprint A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease
    H L Melrose
    Molecular Genetics Laboratory and Core, Morris K Udall Parkinson s Disease Research Center of Excellence, Mayo Clinic, Department of Neuroscience, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Neuroscience 147:1047-58. 2007
    ..A role for Lrrk2 in neurogenesis might provide further insight into the aberrant role of mutant protein in age-associated neurodegeneration with pleomorphic pathology...
  6. pmc Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice
    H L Melrose
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
    Neurobiol Dis 40:503-17. 2010
    ..We hypothesize that Lrrk2 may impact on tau processing which subsequently leads to increased phosphorylation. Our models will be useful for further understanding of the mechanistic actions of LRRK2 and future therapeutic screening...