H L Melrose

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc LRRK2 and ubiquitination: implications for kinase inhibitor therapy
    Heather L Melrose
    Department of Neuroscience, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, U S A
    Biochem J 470:e21-4. 2015
  2. pmc Update on the functional biology of Lrrk2
    Heather Melrose
    Morris K Udall Parkinson s Disease Research Center of Excellence, Neurogenetics Laboratories, Birdsall Bldg, Mayo Clinic, Department of Neuroscience, 4500 San Pablo Road, Jacksonville, FL 32224, USA, Tel 1 904 953 0158
    Future Neurol 3:669-681. 2008
  3. pmc LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors
    Kelly M Hinkle
    Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224, USA
    Mol Neurodegener 7:25. 2012
  4. pmc ER stress response plays an important role in aggregation of α-synuclein
    Peizhou Jiang
    Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, Florida 32224, USA
    Mol Neurodegener 5:56. 2010
  5. pmc In vivo silencing of alpha-synuclein using naked siRNA
    Jada Lewis
    Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Mol Neurodegener 3:19. 2008
  6. ncbi Anatomical localization of leucine-rich repeat kinase 2 in mouse brain
    H Melrose
    Department of Neuroscience, Genetics of Parkinsonism and Related Disorders, Morris K Udall Parkinson s Disease Research Center of Excellence, Birdsall Building, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Neuroscience 139:791-4. 2006
  7. ncbi A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease
    H L Melrose
    Molecular Genetics Laboratory and Core, Morris K Udall Parkinson s Disease Research Center of Excellence, Mayo Clinic, Department of Neuroscience, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Neuroscience 147:1047-58. 2007
  8. pmc Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice
    H L Melrose
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
    Neurobiol Dis 40:503-17. 2010
  9. pmc Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice
    M Yue
    Dept of Neuroscience, Mayo Clinic Jacksonville, Jacksonville FL 32224, USA
    Neurobiol Dis 78:172-95. 2015

Collaborators

  • L Zhang
  • J G Culvenor
  • Z K Wszolek
  • S Lincoln
  • M Boules
  • DENNIS WILLIAM DICKSON
  • O A Ross
  • C Janus
  • Matthew James Farrer
  • M Yue
  • Kelly M Hinkle
  • Wen Lang Lin
  • Peizhou Jiang
  • Jada Lewis
  • F C Fiesel
  • W Springer
  • A S Schroeder
  • A Kurti
  • E Bowles
  • B Behrouz
  • J E Beevers
  • K M Hinkle
  • P J McLean
  • P Davies
  • T A Christenson
  • J D Fryer
  • E Trushina
  • A J Milnerwood
  • Mei Yue
  • Caroline B Kent
  • Iryna Prots
  • Brittany Dugger
  • Justus C Dachsel
  • Joel E Beevers
  • Beate Winner
  • Kenya Nishioka
  • Bahareh Behrouz
  • Erin E Bowles
  • Abdul Shukkur Ebrahim
  • Ming Gan
  • Shu Hui C Yen
  • Rajendra K Pandey
  • Klaus Charisse
  • David Bumcrot
  • Julia Crook
  • Zhen He
  • Sina Ogholikhan
  • Michael Heckman
  • Ivanka Toudjarska
  • Demetrius M Maraganore
  • Kelly Hinkle
  • Caroline Kent
  • Adam Braithwaite
  • Cynthia Zehr
  • Andrew Hope
  • Ravi Braich

Detail Information

Publications9

  1. pmc LRRK2 and ubiquitination: implications for kinase inhibitor therapy
    Heather L Melrose
    Department of Neuroscience, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, U S A
    Biochem J 470:e21-4. 2015
    ..Albeit negative from a kinase inhibitor standpoint, the data open new avenues for LRRK2 biology and therapeutic approaches to counteract LRRK2 toxicity. ..
  2. pmc Update on the functional biology of Lrrk2
    Heather Melrose
    Morris K Udall Parkinson s Disease Research Center of Excellence, Neurogenetics Laboratories, Birdsall Bldg, Mayo Clinic, Department of Neuroscience, 4500 San Pablo Road, Jacksonville, FL 32224, USA, Tel 1 904 953 0158
    Future Neurol 3:669-681. 2008
    ..This review aims to highlight the research effort concentrated on elucidating the functional biological role of Lrrk2, and to provide some future therapeutic perspectives...
  3. pmc LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors
    Kelly M Hinkle
    Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224, USA
    Mol Neurodegener 7:25. 2012
    ..Finally, we confirm that loss of LRRK2 caused degeneration in the kidney, accompanied by a progressive enhancement of autophagic activity and accumulation of autofluorescent material, but without evidence of biphasic changes...
  4. pmc ER stress response plays an important role in aggregation of α-synuclein
    Peizhou Jiang
    Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, Florida 32224, USA
    Mol Neurodegener 5:56. 2010
    ..These drugs have been demonstrated to protect cells transiently overexpressing α-synuclein from its toxicity...
  5. pmc In vivo silencing of alpha-synuclein using naked siRNA
    Jada Lewis
    Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Mol Neurodegener 3:19. 2008
    ..Genetic variability in SNCA contributes to risk of idiopathic Parkinson's disease (PD), possibly as a result of overexpression. SNCA downregulation is therefore a valid therapeutic target for PD...
  6. ncbi Anatomical localization of leucine-rich repeat kinase 2 in mouse brain
    H Melrose
    Department of Neuroscience, Genetics of Parkinsonism and Related Disorders, Morris K Udall Parkinson s Disease Research Center of Excellence, Birdsall Building, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Neuroscience 139:791-4. 2006
    ..Consistent with a role LRRK2 in Parkinson's disease, dysfunction of leucine-rich repeat kinase 2 protein in dopamine-innervated areas may to lead to altered dopaminergic neurotransmission and degeneration of the nigro-striatal pathway...
  7. ncbi A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease
    H L Melrose
    Molecular Genetics Laboratory and Core, Morris K Udall Parkinson s Disease Research Center of Excellence, Mayo Clinic, Department of Neuroscience, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Neuroscience 147:1047-58. 2007
    ..A role for Lrrk2 in neurogenesis might provide further insight into the aberrant role of mutant protein in age-associated neurodegeneration with pleomorphic pathology...
  8. pmc Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice
    H L Melrose
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
    Neurobiol Dis 40:503-17. 2010
    ..We hypothesize that Lrrk2 may impact on tau processing which subsequently leads to increased phosphorylation. Our models will be useful for further understanding of the mechanistic actions of LRRK2 and future therapeutic screening...
  9. pmc Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice
    M Yue
    Dept of Neuroscience, Mayo Clinic Jacksonville, Jacksonville FL 32224, USA
    Neurobiol Dis 78:172-95. 2015
    ..We anticipate that this G2019S mouse line will be a useful pre-clinical model for further evaluation of early mechanistic events in LRRK2 pathogenesis and for second-hit approaches to model disease progression...