H L Melrose

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Update on the functional biology of Lrrk2
    Heather Melrose
    Morris K Udall Parkinson s Disease Research Center of Excellence, Neurogenetics Laboratories, Birdsall Bldg, Mayo Clinic, Department of Neuroscience, 4500 San Pablo Road, Jacksonville, FL 32224, USA, Tel 1 904 953 0158
    Future Neurol 3:669-681. 2008
  2. pmc LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors
    Kelly M Hinkle
    Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224, USA
    Mol Neurodegener 7:25. 2012
  3. pmc ER stress response plays an important role in aggregation of α-synuclein
    Peizhou Jiang
    Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, Florida 32224, USA
    Mol Neurodegener 5:56. 2010
  4. pmc In vivo silencing of alpha-synuclein using naked siRNA
    Jada Lewis
    Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Mol Neurodegener 3:19. 2008
  5. ncbi Anatomical localization of leucine-rich repeat kinase 2 in mouse brain
    H Melrose
    Department of Neuroscience, Genetics of Parkinsonism and Related Disorders, Morris K Udall Parkinson s Disease Research Center of Excellence, Birdsall Building, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Neuroscience 139:791-4. 2006
  6. ncbi A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease
    H L Melrose
    Molecular Genetics Laboratory and Core, Morris K Udall Parkinson s Disease Research Center of Excellence, Mayo Clinic, Department of Neuroscience, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Neuroscience 147:1047-58. 2007
  7. pmc Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice
    H L Melrose
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
    Neurobiol Dis 40:503-17. 2010

Collaborators

  • J G Culvenor
  • M Boules
  • S Lincoln
  • Z K Wszolek
  • DENNIS WILLIAM DICKSON
  • O A Ross
  • C Janus
  • Matthew James Farrer
  • Kelly M Hinkle
  • Wen Lang Lin
  • Peizhou Jiang
  • Jada Lewis
  • Beate Winner
  • Brittany Dugger
  • Caroline B Kent
  • Erin E Bowles
  • Bahareh Behrouz
  • Joel E Beevers
  • Iryna Prots
  • Mei Yue
  • Kenya Nishioka
  • Justus C Dachsel
  • Shu Hui C Yen
  • Abdul Shukkur Ebrahim
  • Ming Gan
  • Kelly Hinkle
  • Ravi Braich
  • Klaus Charisse
  • Ivanka Toudjarska
  • Zhen He
  • Cynthia Zehr
  • Julia Crook
  • Michael Heckman
  • David Bumcrot
  • Adam Braithwaite
  • Demetrius M Maraganore
  • Caroline Kent
  • Rajendra K Pandey
  • Sina Ogholikhan
  • Andrew Hope

Detail Information

Publications7

  1. pmc Update on the functional biology of Lrrk2
    Heather Melrose
    Morris K Udall Parkinson s Disease Research Center of Excellence, Neurogenetics Laboratories, Birdsall Bldg, Mayo Clinic, Department of Neuroscience, 4500 San Pablo Road, Jacksonville, FL 32224, USA, Tel 1 904 953 0158
    Future Neurol 3:669-681. 2008
    ..This review aims to highlight the research effort concentrated on elucidating the functional biological role of Lrrk2, and to provide some future therapeutic perspectives...
  2. pmc LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors
    Kelly M Hinkle
    Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224, USA
    Mol Neurodegener 7:25. 2012
    ..Finally, we confirm that loss of LRRK2 caused degeneration in the kidney, accompanied by a progressive enhancement of autophagic activity and accumulation of autofluorescent material, but without evidence of biphasic changes...
  3. pmc ER stress response plays an important role in aggregation of α-synuclein
    Peizhou Jiang
    Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, Florida 32224, USA
    Mol Neurodegener 5:56. 2010
    ..These drugs have been demonstrated to protect cells transiently overexpressing α-synuclein from its toxicity...
  4. pmc In vivo silencing of alpha-synuclein using naked siRNA
    Jada Lewis
    Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Mol Neurodegener 3:19. 2008
    ..Genetic variability in SNCA contributes to risk of idiopathic Parkinson's disease (PD), possibly as a result of overexpression. SNCA downregulation is therefore a valid therapeutic target for PD...
  5. ncbi Anatomical localization of leucine-rich repeat kinase 2 in mouse brain
    H Melrose
    Department of Neuroscience, Genetics of Parkinsonism and Related Disorders, Morris K Udall Parkinson s Disease Research Center of Excellence, Birdsall Building, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Neuroscience 139:791-4. 2006
    ..Consistent with a role LRRK2 in Parkinson's disease, dysfunction of leucine-rich repeat kinase 2 protein in dopamine-innervated areas may to lead to altered dopaminergic neurotransmission and degeneration of the nigro-striatal pathway...
  6. ncbi A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease
    H L Melrose
    Molecular Genetics Laboratory and Core, Morris K Udall Parkinson s Disease Research Center of Excellence, Mayo Clinic, Department of Neuroscience, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Neuroscience 147:1047-58. 2007
    ..A role for Lrrk2 in neurogenesis might provide further insight into the aberrant role of mutant protein in age-associated neurodegeneration with pleomorphic pathology...
  7. pmc Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice
    H L Melrose
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
    Neurobiol Dis 40:503-17. 2010
    ..We hypothesize that Lrrk2 may impact on tau processing which subsequently leads to increased phosphorylation. Our models will be useful for further understanding of the mechanistic actions of LRRK2 and future therapeutic screening...