M A McNiven

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. ncbi request reprint Focus on membrane dynamics
    Mark A McNiven
    Trends Cell Biol 16:485-6. 2006
  2. doi request reprint Breaking away: matrix remodeling from the leading edge
    Mark A McNiven
    Department of Biochemistry and Molecular Biology and Center for Basic Research in Digestive Diseases, Mayo Clinic and Graduate School, Rochester, MN 55905, USA
    Trends Cell Biol 23:16-21. 2013
  3. ncbi request reprint The dynamin family of mechanoenzymes: pinching in new places
    M A McNiven
    Dept of Biochemistry and Molecular Biology, The Center for Basic Research in Digestive Diseases, Mayo Foundation, Rochester, MN 55905, USA
    Trends Biochem Sci 25:115-20. 2000
  4. ncbi request reprint Vesicle formation at the plasma membrane and trans-Golgi network: the same but different
    Mark A McNiven
    Department of Biochemistry and Molecular Biology and the Miles and Shirley Fiterman Center for Digestive Diseases, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Science 313:1591-4. 2006
  5. ncbi request reprint Big gulps: specialized membrane domains for rapid receptor-mediated endocytosis
    Mark A McNiven
    Department of Biochemistry and Molecular Biology and the Miles and Shirley Fiterman Center for Digestive Diseases, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Trends Cell Biol 16:487-92. 2006
  6. pmc The dynamin-like protein DLP1 is essential for normal distribution and morphology of the endoplasmic reticulum and mitochondria in mammalian cells
    K R Pitts
    Department of Biochemistry and Molecular Biology and Center for Basic Research in Digestive Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA
    Mol Biol Cell 10:4403-17. 1999
  7. pmc Regulated interactions between dynamin and the actin-binding protein cortactin modulate cell shape
    M A McNiven
    Department of Biochemistry and Molecular Biology, Center for Basic Research in Digestive Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Cell Biol 151:187-98. 2000
  8. pmc Mammalian dynamin-like protein DLP1 tubulates membranes
    Y Yoon
    Center for Basic Research in Digestive Diseases, Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA
    Mol Biol Cell 12:2894-905. 2001
  9. pmc A novel dynamin-like protein associates with cytoplasmic vesicles and tubules of the endoplasmic reticulum in mammalian cells
    Y Yoon
    Center for Basic Research in Digestive Diseases and Department of Biochemistry and Molecular Biology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Cell Biol 140:779-93. 1998
  10. pmc Differential distribution of dynamin isoforms in mammalian cells
    H Cao
    Department of Biochemistry and Molecular Biology and Center for Basic Research in Digestive Diseases, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Mol Biol Cell 9:2595-609. 1998

Collaborators

  • Jing Chen
  • Xian Ming Chen
  • J M Larkin
  • L Zhang
  • S G Weller
  • RADU STAN
  • MARK A STAMNES
  • Alberto Luini
  • V H Shah
  • A Ridley
  • Hong Cao
  • James D Orth
  • Eugene W Krueger
  • Lidiya Orlichenko
  • Y Yoon
  • Pamela S Tietz
  • Bing Huang
  • Noah W Gray
  • Resham Bhattacharya
  • R D Eppinga
  • Heather M Thompson
  • Barbara Schroeder
  • Sanjib Bhattacharyya
  • H Cao
  • K R Pitts
  • Susan Chi
  • Vijay P Singh
  • Muyiwa Awoniyi
  • Priyabrata Mukherjee
  • Eugene Krueger
  • E W Krueger
  • Sophie Dahan
  • Qing Yao
  • Nicholas F Larusso
  • Victoria J Allan
  • N J Török
  • N Kang-Decker
  • DANIEL BILLADEAU
  • Steven Curley
  • Galina Beznoussenko
  • Roberto Buccione
  • R Urrutia
  • John R Henley
  • Patrick L Splinter
  • Bing Q Huang
  • Karen L Anderson
  • Ningling Kang-Decker
  • Anne E Kruchten
  • Deborah A Hughes
  • J Michael McCaffery
  • Debabrata Mukhopadhyay
  • Seth Alper
  • Lawrence Fourgeaud
  • Barbara J Oswald
  • Agnes Hemar
  • Jonathan Cohn
  • Raul A Marinelli
  • John E Heuser
  • Jolanta Kole
  • J M van Deursen
  • G T Mantchev
  • S C Juneja
  • E M Larusso
  • F Garcia
  • T A Cook
  • D L Marks
  • S Dahan
  • T Cook
  • J R Henley

Detail Information

Publications47

  1. ncbi request reprint Focus on membrane dynamics
    Mark A McNiven
    Trends Cell Biol 16:485-6. 2006
  2. doi request reprint Breaking away: matrix remodeling from the leading edge
    Mark A McNiven
    Department of Biochemistry and Molecular Biology and Center for Basic Research in Digestive Diseases, Mayo Clinic and Graduate School, Rochester, MN 55905, USA
    Trends Cell Biol 23:16-21. 2013
    ..From these approaches, it has become increasingly evident that the conventional definitions of these invasive structures may be less clear than was previously thought...
  3. ncbi request reprint The dynamin family of mechanoenzymes: pinching in new places
    M A McNiven
    Dept of Biochemistry and Molecular Biology, The Center for Basic Research in Digestive Diseases, Mayo Foundation, Rochester, MN 55905, USA
    Trends Biochem Sci 25:115-20. 2000
    ..The potential contributions by the dynamin family to these diverse but related functions are discussed...
  4. ncbi request reprint Vesicle formation at the plasma membrane and trans-Golgi network: the same but different
    Mark A McNiven
    Department of Biochemistry and Molecular Biology and the Miles and Shirley Fiterman Center for Digestive Diseases, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Science 313:1591-4. 2006
    ..Such similarity is found both at the level of the receptor-ligand sequestration process that uses clathrin and associated polymeric and monomeric adaptor proteins, and in the machinery used to deform and vesiculate lipid membranes...
  5. ncbi request reprint Big gulps: specialized membrane domains for rapid receptor-mediated endocytosis
    Mark A McNiven
    Department of Biochemistry and Molecular Biology and the Miles and Shirley Fiterman Center for Digestive Diseases, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Trends Cell Biol 16:487-92. 2006
    ..Here, some new insights into how cells cluster and organize the endocytic machinery at defined cytoplasmic domains to increase the speed and efficiency of ligand-receptor internalization are presented...
  6. pmc The dynamin-like protein DLP1 is essential for normal distribution and morphology of the endoplasmic reticulum and mitochondria in mammalian cells
    K R Pitts
    Department of Biochemistry and Molecular Biology and Center for Basic Research in Digestive Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA
    Mol Biol Cell 10:4403-17. 1999
    ..How DLP1 might participate in the biogenesis of two presumably distinct organelle systems is discussed...
  7. pmc Regulated interactions between dynamin and the actin-binding protein cortactin modulate cell shape
    M A McNiven
    Department of Biochemistry and Molecular Biology, Center for Basic Research in Digestive Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Cell Biol 151:187-98. 2000
    ..These findings provide the first demonstration that dynamin can interact with the actin cytoskeleton to regulate actin reorganization and subsequently cell shape...
  8. pmc Mammalian dynamin-like protein DLP1 tubulates membranes
    Y Yoon
    Center for Basic Research in Digestive Diseases, Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA
    Mol Biol Cell 12:2894-905. 2001
    ..Furthermore, these findings also indicate that despite the limited homology to conventional dynamins (35%) these proteins remodel membranes in a similar manner...
  9. pmc A novel dynamin-like protein associates with cytoplasmic vesicles and tubules of the endoplasmic reticulum in mammalian cells
    Y Yoon
    Center for Basic Research in Digestive Diseases and Department of Biochemistry and Molecular Biology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Cell Biol 140:779-93. 1998
    ..These observations provide the first evidence that a novel dynamin-like protein is expressed in mammalian cells where it associates with a secretory, rather than endocytic membrane compartment...
  10. pmc Differential distribution of dynamin isoforms in mammalian cells
    H Cao
    Department of Biochemistry and Molecular Biology and Center for Basic Research in Digestive Diseases, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Mol Biol Cell 9:2595-609. 1998
    ..These results indicate that the dynamin family is more extensive than was originally predicted and suggest that the different dynamin proteins are localized to distinct cytoplasmic or membrane compartments...
  11. pmc Ethanol-induced retention of nascent proteins in rat hepatocytes is accompanied by altered distribution of the small GTP-binding protein rab2
    J M Larkin
    Center for Basic Research in Digestive Diseases, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Clin Invest 98:2146-57. 1996
    ..The effects of ethanol exposure on rab proteins and Golgi function are discussed...
  12. pmc The dynamins: redundant or distinct functions for an expanding family of related GTPases?
    R Urrutia
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA
    Proc Natl Acad Sci U S A 94:377-84. 1997
    ..The purpose of this review is to enumerate on the expansive dynamin literature and to discuss the nomenclature, expression, and putative functions of this growing and interesting family of proteins...
  13. ncbi request reprint Association of kinesin with the Golgi apparatus in rat hepatocytes
    D L Marks
    Center for Basic Research in Digestive Diseases, Mayo Clinic, Rochester, MN 55905
    J Cell Sci 107:2417-26. 1994
    ..These results provide compelling evidence showing that kinesin is associated with the Golgi complex in cells and implicate this motor enzyme in Golgi structure, function and dynamics...
  14. ncbi request reprint Lack of acrosome formation in Hrb-deficient mice
    N Kang-Decker
    Department of Pediatrics and Adolescent Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Science 294:1531-3. 2001
    ..We conclude that Hrb is required for docking and/or fusion of proacrosomic vesicles during acrosome biogenesis...
  15. ncbi request reprint Dynamin: a molecular motor with pinchase action
    M A McNiven
    Department of Biochemistry and Molecular Biology, The Center for Basic Research in Digestive Diseases, Mayo Foundation, Rochester, Minnesota 55905, USA
    Cell 94:151-4. 1998
  16. ncbi request reprint Mitochondrial division: New partners in membrane pinching
    Y Yoon
    Center for Basic Research in Digestive Diseases and Department of Biochemistry and Molecular Biology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Curr Biol 11:R67-70. 2001
    ..Recent studies have identified a number of these factors and started to elucidate how they act together to bring about mitochondrial fission...
  17. pmc Increased expression of the large GTPase dynamin 2 potentiates metastatic migration and invasion of pancreatic ductal carcinoma
    R D Eppinga
    Department of Biochemistry and Molecular Biology, Center for Digestive Diseases, Rochester, MN, USA
    Oncogene 31:1228-41. 2012
    ..These findings are the first to implicate dynamin in any neoplastic condition and to directly demonstrate a role for this mechanoenzyme in invasive cell migration...
  18. pmc Eps15 mediates vesicle trafficking from the trans-Golgi network via an interaction with the clathrin adaptor AP-1
    Susan Chi
    Mayo Clinic College of Medicine, Department of Biochemistry and Molecular Biology, and the Miles and Shirley Fiterman Center for Digestive Diseases, Rochester, MN 55905, USA
    Mol Biol Cell 19:3564-75. 2008
    ..Together, these findings indicate that Eps15 plays an important role in clathrin-coated vesicle formation not only at the plasma membrane but also at the TGN during the secretory process...
  19. pmc Cortactin is a component of clathrin-coated pits and participates in receptor-mediated endocytosis
    Hong Cao
    Department of Biochemistry and Molecular Biology, Mayo Clinic, 1721 Guggenheim Building, Rochester, MN 55905, USA
    Mol Cell Biol 23:2162-70. 2003
    ..Thus, cortactin provides a direct link between the dynamic actin cytoskeleton and the membrane pinchase dynamin that supports vesicle formation during receptor-mediated endocytosis...
  20. ncbi request reprint Alterations in vesicle transport and cell polarity in rat hepatocytes subjected to mechanical or chemical cholestasis
    N J Török
    Center for Basic Research in Digestive Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA
    Gastroenterology 121:1176-84. 2001
    ..The molecular mechanisms that contribute to the cholestatic condition in hepatocytes are poorly defined. It has been postulated that a disruption of normal vesicle-based protein trafficking may lead to alterations in hepatocyte polarity...
  21. ncbi request reprint Cryptosporidium parvum invasion of biliary epithelia requires host cell tyrosine phosphorylation of cortactin via c-Src
    Xian Ming Chen
    Center for Basic Research in Digestive Diseases, Division of Gastroenterology and Hepatology, Mayo Medical School, Clinic and Foundation, Rochester, Minnesota 55905, USA
    Gastroenterology 125:216-28. 2003
    ..We analyzed the role of host cell c-Src, a cytoskeleton-associated protein tyrosine kinase, in C. parvum invasion of biliary epithelia...
  22. pmc Identification of dynamin 2, an isoform ubiquitously expressed in rat tissues
    T A Cook
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905
    Proc Natl Acad Sci U S A 91:644-8. 1994
    ....
  23. pmc SRC-mediated phosphorylation of dynamin and cortactin regulates the "constitutive" endocytosis of transferrin
    Hong Cao
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA
    Mol Cell Biol 30:781-92. 2010
    ..To our knowledge these findings are among the first to implicate an Src-mediated endocytic cascade in what was previously presumed to be a nonregulated internalization process...
  24. pmc A Dyn2-CIN85 complex mediates degradative traffic of the EGFR by regulation of late endosomal budding
    Barbara Schroeder
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA
    EMBO J 29:3039-53. 2010
    ..These findings provide novel insights into a previously unknown protein complex that can regulate EGFR traffic at very late stages of the endocytic pathway...
  25. ncbi request reprint Get off my back! Rapid receptor internalization through circular dorsal ruffles
    James D Orth
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Cancer Res 66:11094-6. 2006
    ..Most importantly, the formation of these structures may be less frequent in tumor cells and thereby have significant effects on receptor signaling and cell growth...
  26. ncbi request reprint Regulatory role of dynamin-2 in VEGFR-2/KDR-mediated endothelial signaling
    Resham Bhattacharya
    Department of Biochemistry and Molecular Biology, Mayo Clinic Cancer Center, Rochester, Minnesota 55905, USA
    FASEB J 19:1692-4. 2005
    ..Taken together, our findings suggest that dynamin-2 regulates KDR expression and function and hence plays an important role in VPF/VEGF mediated angiogenesis...
  27. ncbi request reprint Actin and Arf1-dependent recruitment of a cortactin-dynamin complex to the Golgi regulates post-Golgi transport
    Hong Cao
    Center for Basic Research in Digestive Diseases and Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Nat Cell Biol 7:483-92. 2005
    ..These findings support the idea of an Arf1-activated recruitment of an actin, cortactin and Dyn2 complex that is essential for Golgi function...
  28. ncbi request reprint Dynamin 3 is a component of the postsynapse, where it interacts with mGluR5 and Homer
    Noah W Gray
    Molecular Neuroscience Program and Graduate School, Mayo Clinic, 200 First Street, S W, Rochester, MN 55905, USA
    Curr Biol 13:510-5. 2003
    ..These data suggest that Dyn3 is a postsynaptic dynamin and, like its binding partner Homer, plays a significant role in dendritic spine morphogenesis and remodeling...
  29. ncbi request reprint Epithelial growth factor-induced phosphorylation of caveolin 1 at tyrosine 14 stimulates caveolae formation in epithelial cells
    Lidiya Orlichenko
    Center for Basic Research in Digestive Diseases and Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Biol Chem 281:4570-9. 2006
    ..This study provides novel insights into how cells regulate caveolae formation and implicates EGF-based signaling cascades in the phosphorylation of Cav1 as a stimulus for caveolae assembly...
  30. pmc Src-mediated cortactin phosphorylation regulates actin localization and injurious blebbing in acinar cells
    Vijay P Singh
    Department of Biochemistry and Molecular Biology and the Miles and Shirley Fiterman Center for Digestive Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Mol Biol Cell 19:2339-47. 2008
    ..In addition, they suggest a potential use for Src inhibitors as an approach to reduce cell injury...
  31. ncbi request reprint Agonist-induced coordinated trafficking of functionally related transport proteins for water and ions in cholangiocytes
    Pamela S Tietz
    Center for Basic Research in Digestive Diseases, Department of Internal Medicine, Mayo Medical School, Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Biol Chem 278:20413-9. 2003
    ....
  32. pmc Caveolae mediate growth factor-induced disassembly of adherens junctions to support tumor cell dissociation
    Lidiya Orlichenko
    Mayo Clinic, Department of Biochemistry and Molecular Biology and the Miles and Shirley Fiterman Center for Digestive Diseases, Rochester, MN 55905, USA
    Mol Biol Cell 20:4140-52. 2009
    ..Together, these findings provide new insights into how cells might disassemble cell-cell contacts to help mediate the remodeling of adherens junctions, and tumor cell metastasis and invasion...
  33. ncbi request reprint Caveolin-1 interacts directly with dynamin-2
    Qing Yao
    Center for Basic Research in Digestive Diseases, and Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA
    J Mol Biol 348:491-501. 2005
    ..These studies provide the first evidence for a direct interaction between dynamin and the caveolin coat, and demonstrate a selectivity of one Dyn2 form toward the caveolae-mediated endocytosis...
  34. pmc Src kinase regulates the integrity and function of the Golgi apparatus via activation of dynamin 2
    Shaun G Weller
    Department of Biochemistry and Molecular Biology and the Miles and Shirley Fiterman Center for Digestive Diseases, Mayo Clinic, Rochester, MN, 55905, USA
    Proc Natl Acad Sci U S A 107:5863-8. 2010
    ..These findings demonstrate that activation of Dyn2 by Src kinase regulates Golgi integrity and vesiculation during the secretory process...
  35. pmc Nanoconjugation modulates the trafficking and mechanism of antibody induced receptor endocytosis
    Sanjib Bhattacharyya
    Department of Biochemistry and Molecular Biology, Cancer Center Mayo Clinic, Rochester, MN 55905, USA
    Proc Natl Acad Sci U S A 107:14541-6. 2010
    ..This information is critical for successful design of a nanoparticle-based targeted drug delivery system for future clinical translation...
  36. pmc A dynamin-cortactin-Arp2/3 complex mediates actin reorganization in growth factor-stimulated cells
    Eugene W Krueger
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Mol Biol Cell 14:1085-96. 2003
    ....
  37. ncbi request reprint Dynamin at the actin-membrane interface
    James D Orth
    Department of Biochemistry and Molecular Biology and The Center for Basic Research in Digestive Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Curr Opin Cell Biol 15:31-9. 2003
    ..Recent data support the concept that the dynamin family might act as a 'polymeric contractile scaffold' at the interface between biological membranes and filamentous actin...
  38. ncbi request reprint Dynamin 2 mediates fluid-phase micropinocytosis in epithelial cells
    Hong Cao
    Mayo Clinic, Department of Biochemistry and Molecular Biology and the Miles and Shirley Fiterman Center for Digestive Diseases, Rochester, MN 55905, USA
    J Cell Sci 120:4167-77. 2007
    ....
  39. ncbi request reprint The role of dynamin in the assembly and function of podosomes and invadopodia
    Mark A McNiven
    Department of Biochemistry and Molecular Biology, Center for Basic Research in Digestive Diseases, Mayo Clinic, Rochester, MN, USA
    Front Biosci 9:1944-53. 2004
    ..Here, we specifically discuss the role played by dynamin in controlling the activities and function of these structures...
  40. ncbi request reprint A dynamin-3 spliced variant modulates the actin/cortactin-dependent morphogenesis of dendritic spines
    Noah W Gray
    Molecular Neuroscience Program and Graduate School, Mayo Clinic, Rochester, MN 55905, USA
    J Cell Sci 118:1279-90. 2005
    ....
  41. ncbi request reprint Agonist-induced vesiculation of the Golgi apparatus in pancreatic acinar cells
    Sophie Dahan
    Center for Basic Research in Digestive Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Gastroenterology 129:2032-46. 2005
    ..In this study, we determined whether agonist stimulation induces morphologic alterations in the acinar cell Golgi apparatus, and we evaluated the role of the vesicle severing protein dynamin...
  42. ncbi request reprint Cytoskeletal and motor proteins facilitate trafficking of AQP1-containing vesicles in cholangiocytes
    Pamela S Tietz
    Center for Basic Research in Digestive Diseases, Department of Internal Medicine, Mayo Medical School, Clinic and Foundation, Rochester, MN 55905, USA
    Biol Cell 98:43-52. 2006
    ..e. ductal bile secretion). The aim of the present study was to determine which proteins and mechanisms regulate AQP1 trafficking in cholangiocytes...
  43. ncbi request reprint A novel endocytic mechanism of epidermal growth factor receptor sequestration and internalization
    James D Orth
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Cancer Res 66:3603-10. 2006
    ..These findings characterize a structure that selectively sequesters large numbers of activated EGFR for their subsequent internalization, independent of traditional endocytic mechanisms such as clathrin pits or caveolae...
  44. pmc Cdc42 and the actin-related protein/neural Wiskott-Aldrich syndrome protein network mediate cellular invasion by Cryptosporidium parvum
    Xian Ming Chen
    The Center for Basic Research in Digestive Diseases, Division of Gastroenterology and Hepatology, Mayo Medical School, Clinic and Foundation, Rochester, Minnesota 55905, USA
    Infect Immun 72:3011-21. 2004
    ..parvum invasion. These data suggest that C. parvum invasion of target epithelia results from the organism's ability to activate a host cell Cdc42 GTPase signaling pathway to induce host cell actin remodeling at the attachment site...
  45. ncbi request reprint Discovery of a new 'dynasore'
    Heather M Thompson
    Nat Chem Biol 2:355-6. 2006
  46. ncbi request reprint Dynamin in disease
    Mark A McNiven
    Nat Genet 37:215-6. 2005
  47. ncbi request reprint Motoring around the Golgi
    Victoria J Allan
    School of Biological Sciences, University of Manchester, Manchester M13 9PT, UK
    Nat Cell Biol 4:E236-42. 2002
    ..Here, we review just some of the many functions performed by these mechanochemical enzymes - dyneins, kinesins, myosins and dynamin - in relation to the Golgi apparatus...