J W McLaren

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. doi request reprint Modeling the effect of forward scatter and aberrations on visual acuity after endothelial keratoplasty
    Jay W McLaren
    Department of Ophthalmology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Invest Ophthalmol Vis Sci 53:5545-51. 2012
  2. pmc Standardization of corneal haze measurement in confocal microscopy
    Jay W McLaren
    Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA
    Invest Ophthalmol Vis Sci 51:5610-6. 2010
  3. ncbi request reprint Corneal thickness measurement by confocal microscopy, ultrasound, and scanning slit methods
    Jay W McLaren
    Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Am J Ophthalmol 137:1011-20. 2004
  4. ncbi request reprint Effect of ibopamine on aqueous humor production in normotensive humans
    Jay W McLaren
    Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Invest Ophthalmol Vis Sci 44:4853-8. 2003
  5. pmc Automated assessment of keratocyte density in clinical confocal microscopy of the corneal stroma
    J W McLaren
    Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Microsc 229:21-31. 2008
  6. pmc Automated assessment of keratocyte density in stromal images from the ConfoScan 4 confocal microscope
    Jay W McLaren
    Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA
    Invest Ophthalmol Vis Sci 51:1918-26. 2010
  7. ncbi request reprint Corneal reinnervation after LASIK: prospective 3-year longitudinal study
    Martha P Calvillo
    Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Invest Ophthalmol Vis Sci 45:3991-6. 2004
  8. ncbi request reprint Mechanism of ocular hypotensive action of bimatoprost (Lumigan) in patients with ocular hypertension or glaucoma
    Gregory A Christiansen
    Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA
    Ophthalmology 111:1658-62. 2004
  9. pmc Mechanism of action of bimatoprost, latanoprost, and travoprost in healthy subjects. A crossover study
    K Sheng Lim
    Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA
    Ophthalmology 115:790-795.e4. 2008
  10. doi request reprint Corneal wavefront errors 24 months after deep lamellar endothelial keratoplasty and penetrating keratoplasty
    Jay W McLaren
    Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Ophthalmol 147:959-65, 965.e1-2. 2009

Collaborators

Detail Information

Publications51

  1. doi request reprint Modeling the effect of forward scatter and aberrations on visual acuity after endothelial keratoplasty
    Jay W McLaren
    Department of Ophthalmology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Invest Ophthalmol Vis Sci 53:5545-51. 2012
    ..To evaluate the effects on visual acuity of forward scatter and aberrations typical of those after Descemet stripping endothelial keratoplasty (DSEK)...
  2. pmc Standardization of corneal haze measurement in confocal microscopy
    Jay W McLaren
    Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA
    Invest Ophthalmol Vis Sci 51:5610-6. 2010
    ..Corneal stromal haze cannot be compared in longitudinal studies or across laboratories without standardization. In this study, a method was devised of standardizing image brightness in confocal microscopy of the cornea...
  3. ncbi request reprint Corneal thickness measurement by confocal microscopy, ultrasound, and scanning slit methods
    Jay W McLaren
    Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Am J Ophthalmol 137:1011-20. 2004
    ..To measure corneal thickness by using a calibrated confocal microscope and to compare this measurement to thickness determined by ultrasonic and noncontact scanning slit pachymetry...
  4. ncbi request reprint Effect of ibopamine on aqueous humor production in normotensive humans
    Jay W McLaren
    Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Invest Ophthalmol Vis Sci 44:4853-8. 2003
    ..Mydriasis can interfere with the measurement of aqueous flow. In this study ibopamine's effect on aqueous humor production was measured while making allowance for the potential artifact caused by its mydriatic effect...
  5. pmc Automated assessment of keratocyte density in clinical confocal microscopy of the corneal stroma
    J W McLaren
    Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Microsc 229:21-31. 2008
    ..In these corneas, which showed a decrease in cell density after surgery, the program identified cells as well as human observers did...
  6. pmc Automated assessment of keratocyte density in stromal images from the ConfoScan 4 confocal microscope
    Jay W McLaren
    Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA
    Invest Ophthalmol Vis Sci 51:1918-26. 2010
    ..The adaptation of our earlier cell-counting program to the ConfoScan 4 provides a timesaving, objective, and reproducible means of determining stromal cell densities in images from the ConfoScan 4...
  7. ncbi request reprint Corneal reinnervation after LASIK: prospective 3-year longitudinal study
    Martha P Calvillo
    Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Invest Ophthalmol Vis Sci 45:3991-6. 2004
    ..To measure the return of innervation to the cornea during 3 years after LASIK...
  8. ncbi request reprint Mechanism of ocular hypotensive action of bimatoprost (Lumigan) in patients with ocular hypertension or glaucoma
    Gregory A Christiansen
    Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA
    Ophthalmology 111:1658-62. 2004
    ..To determine the mechanism of ocular hypotensive action of bimatoprost in patients with ocular hypertension or glaucoma...
  9. pmc Mechanism of action of bimatoprost, latanoprost, and travoprost in healthy subjects. A crossover study
    K Sheng Lim
    Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA
    Ophthalmology 115:790-795.e4. 2008
    ..To study the effects of 3 prostaglandin analogs, bimatoprost, latanoprost, and travoprost, on aqueous dynamics in the same subjects and to compare techniques of assessing outflow facility...
  10. doi request reprint Corneal wavefront errors 24 months after deep lamellar endothelial keratoplasty and penetrating keratoplasty
    Jay W McLaren
    Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Ophthalmol 147:959-65, 965.e1-2. 2009
    ..To evaluate high-order aberrations (HOA) induced by the anterior corneal surface after deep lamellar endothelial keratoplasty (DLEK) and penetrating keratoplasty (PK)...
  11. ncbi request reprint Keratocyte density of central human cornea after laser in situ keratomileusis
    Katsuya Mitooka
    Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Ophthalmol 133:307-14. 2002
    ..To determine changes in keratocyte density in the first year after laser in situ keratomileusis (LASIK)...
  12. pmc Keratocyte and subbasal nerve density after penetrating keratoplasty
    Sanjay V Patel
    Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Trans Am Ophthalmol Soc 105:180-9; discussion 189-90. 2007
    ..To determine central keratocyte and subbasal nerve densities after penetrating keratoplasty (PK) in clear grafts and in grafts with late endothelial failure (LEF)...
  13. ncbi request reprint Reinnervation in the cornea after LASIK
    Bong Hwan Lee
    Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA
    Invest Ophthalmol Vis Sci 43:3660-4. 2002
    ..In this study, the denervation and reinnervation of human central corneas were evaluated by sequential, quantitative measurements of nerves viewed by confocal microscopy in vivo during the first year after LASIK...
  14. ncbi request reprint Recovery of corneal subbasal nerve density after PRK and LASIK
    Jay C Erie
    Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, Minnesota
    Am J Ophthalmol 140:1059-1064. 2005
    ..To measure and compare the return of corneal innervation up to 5 years after photorefractive keratectomy (PRK) and laser in situ keratomileusis (LASIK)...
  15. ncbi request reprint Confocal microscopy in vivo in corneas of long-term contact lens wearers
    Sanjay V Patel
    Department of Ophthalmology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Invest Ophthalmol Vis Sci 43:995-1003. 2002
    ..To compare keratocyte density, stromal backscatter, epithelial thickness, and corneal sensitivity between corneas of long-term contact lens wearers and those of non-contact lens wearers...
  16. pmc Corneal aberrations and visual acuity after laser in situ keratomileusis: femtosecond laser versus mechanical microkeratome
    Ramón Calvo
    Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905, USA
    Am J Ophthalmol 149:785-93. 2010
    ..To compare corneal high-order aberrations and visual acuity after laser in situ keratomileusis (LASIK) with the flap created by a femtosecond laser (bladeless) to LASIK with the flap created by a mechanical microkeratome...
  17. pmc Long-term corneal keratoctye deficits after photorefractive keratectomy and laser in situ keratomileusis
    Jay C Erie
    Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Trans Am Ophthalmol Soc 103:56-66; discussion 67-8. 2005
    ..To measure changes in keratocyte density up to 5 years after photorefractive keratectomy (PRK) and laser in situ keratomileusis (LASIK)...
  18. ncbi request reprint Comparison of effects of topical ibopamine and epinephrine on the circadian rhythm of intraocular pressure of the rabbit eye as measured by telemetry
    J W McLaren
    Department of Ophthalmology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA
    J Ocul Pharmacol Ther 15:107-16. 1999
    ..Since ibopamine is a pro-drug of deoxyepinephrine (N-methyl dopamine, epinine), its effects are assumed to be due to this metabolite, a metabolite that is structurally similar to epinephrine...
  19. doi request reprint Host and graft thickness after Descemet stripping endothelial keratoplasty for Fuchs endothelial dystrophy
    Kamran A Ahmed
    Mayo Medical School, Mayo Clinic, Rochester, MN 55905, USA
    Am J Ophthalmol 150:490-497.e2. 2010
    ..To determine relationships between vision, forward scatter, and total corneal and graft thicknesses after Descemet stripping endothelial keratoplasty (DSEK)...
  20. ncbi request reprint Analysis of postoperative glare and intraocular lens design
    J C Erie
    Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Cataract Refract Surg 27:614-21. 2001
    ..To assess the potential for reflected glare images from commonly used intraocular lens (IOL) materials and designs...
  21. ncbi request reprint The effect of age on the corneal subbasal nerve plexus
    Jay C Erie
    Department of Ophthalmology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cornea 24:705-9. 2005
    ..To measure subbasal nerve density and orientation in normal human corneas across a broad age range...
  22. ncbi request reprint Clinical responses of the corneal endothelium
    William M Bourne
    Mayo Clinic, Department of Ophthalmology, 200 First Street SW, Rochester, MN 55905, USA
    Exp Eye Res 78:561-72. 2004
    ..We describe the clinical responses of the corneal endothelium to aging, drugs, glaucoma, contact lens wear, trauma, disease, and surgery...
  23. ncbi request reprint Keratocyte density in the human cornea after photorefractive keratectomy
    Jay C Erie
    Department of Ophthalmology, Mayo Clinic, Rochester, Minn 55905, USA
    Arch Ophthalmol 121:770-6. 2003
    ..To perform a quantitative analysis of keratocyte density in human corneas after photorefractive keratectomy (PRK)...
  24. pmc The effect of corneal light scatter on vision after penetrating keratoplasty
    Sanjay V Patel
    Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Ophthalmol 146:913-9. 2008
    ..To determine the effect of corneal light scatter on vision after penetrating keratoplasty (PK)...
  25. ncbi request reprint Effect of myopic laser in situ keratomileusis on epithelial and stromal thickness: a confocal microscopy study
    Jay C Erie
    Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA
    Ophthalmology 109:1447-52. 2002
    ..To determine changes in central epithelial and stromal thickness in human corneas in vivo after laser in situ keratomileusis (LASIK)...
  26. doi request reprint The effect of corneal light scatter on vision after descemet stripping with endothelial keratoplasty
    Sanjay V Patel
    Department of Ophthalmology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Arch Ophthalmol 127:153-60. 2009
    ..To establish an association between corneal light scatter and vision after Descemet stripping with endothelial keratoplasty (DSEK)...
  27. doi request reprint Confocal microscopy in ophthalmology
    Jay C Erie
    Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905, USA
    Am J Ophthalmol 148:639-46. 2009
    ..To describe the principles, capabilities, and applications of confocal microscopy in vivo in ophthalmology...
  28. ncbi request reprint Keratocyte density in keratoconus. A confocal microscopy study(a)
    Jay C Erie
    Departments of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA
    Am J Ophthalmol 134:689-95. 2002
    ..To estimate keratocyte density in human corneas with keratoconus by confocal microscopy...
  29. doi request reprint Comparison of flex-center, center, and corner methods of corneal endothelial cell analysis
    Sanjay V Patel
    Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905, USA
    Cornea 29:1042-7. 2010
    ..In this study, we examined agreement among the flex-center, center, and corner (standard) methods of endothelial analysis...
  30. doi request reprint Subbasal nerve density and corneal sensitivity after laser in situ keratomileusis: femtosecond laser vs mechanical microkeratome
    Sanjay V Patel
    Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905, USA
    Arch Ophthalmol 128:1413-9. 2010
    ..To compare changes in subbasal nerve density and corneal sensitivity after laser in situ keratomileusis (LASIK) with the flap created by a femtosecond laser (bladeless) vs a mechanical microkeratome...
  31. doi request reprint Anterior keratocyte depletion in fuchs endothelial dystrophy
    Laura A Hecker
    Department of Ophthalmology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Arch Ophthalmol 129:555-61. 2011
    ..To determine if keratocyte populations are different in corneas with Fuchs dystrophy compared with control corneas...
  32. pmc Circadian variation of aqueous dynamics in young healthy adults
    Arthur J Sit
    Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Invest Ophthalmol Vis Sci 49:1473-9. 2008
    ..This study was undertaken to investigate whether changes in outflow facility, episcleral venous pressure, or uveoscleral flow at night could account for the nocturnal IOP...
  33. ncbi request reprint Femtosecond laser versus mechanical microkeratome for LASIK: a randomized controlled study
    Sanjay V Patel
    Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Ophthalmology 114:1482-90. 2007
    ..To compare corneal haze (backscattered light) and visual outcomes between fellow eyes randomized to LASIK with the flap created by a femtosecond laser (bladeless) or with the flap created by a mechanical microkeratome...
  34. ncbi request reprint Corneal keratocyte deficits after photorefractive keratectomy and laser in situ keratomileusis
    Jay C Erie
    Department of Ophthalmology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Am J Ophthalmol 141:799-809. 2006
    ..To measure changes in keratocyte density up to five years after photorefractive keratectomy (PRK) and laser in situ keratomileusis (LASIK)...
  35. ncbi request reprint Effects of glaucoma medications on corneal endothelium, keratocytes, and subbasal nerves among participants in the ocular hypertension treatment study
    Keith H Baratz
    Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Cornea 25:1046-52. 2006
    ..To compare subbasal corneal nerve and keratocyte density and endothelial characteristics of ocular hypertensive patients treated with medications or observation...
  36. ncbi request reprint Objective measurement of backscattered light from the anterior and posterior cornea in vivo
    Sanjay V Patel
    Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Invest Ophthalmol Vis Sci 48:166-72. 2007
    ..To develop an objective and repeatable method of measuring corneal backscattered light from different depths of the cornea in vivo...
  37. ncbi request reprint Long-term keratocyte deficits in the corneal stroma after LASIK
    Jay C Erie
    Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Ophthalmology 111:1356-61. 2004
    ..To determine changes in keratocyte density up to 3 years after LASIK...
  38. ncbi request reprint Confocal microscopy changes in epithelial and stromal thickness up to 7 years after LASIK and photorefractive keratectomy for myopia
    Sanjay V Patel
    Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, Minn, USA
    J Refract Surg 23:385-92. 2007
    ..To determine the long-term changes in epithelial, stromal, and corneal thickness after LASIK and photorefractive keratectomy (PRK)...
  39. ncbi request reprint Retinal image stability in head tremor and nystagmus: counterintuitive observations
    Brian R Younge
    Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Neuroophthalmol 27:107-14. 2007
    ..Ophthalmoscopy of the fundus in a patient with head tremor is facilitated by image stability, whereas such observation of a patient with nystagmus is made difficult by image movement. Why does this occur?..
  40. doi request reprint Measurement of aqueous humor flow
    Jay W McLaren
    Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905, USA
    Exp Eye Res 88:641-7. 2009
    ..Studies of the production and circulation of aqueous humor have provided a basis for understanding the fundamental dynamics of the eye as well as understanding treatments for glaucoma...
  41. ncbi request reprint Keratocyte density and recovery of subbasal nerves after penetrating keratoplasty and in late endothelial failure
    Sanjay V Patel
    Department of Ophthalmology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Arch Ophthalmol 125:1693-8. 2007
    ..To determine central keratocyte and subbasal nerve densities in clear and failed grafts after penetrating keratoplasty...
  42. ncbi request reprint Scattered light and visual function in a randomized trial of deep lamellar endothelial keratoplasty and penetrating keratoplasty
    Sanjay V Patel
    Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Am J Ophthalmol 145:97-105. 2008
    ..To compare vision, intraocular forward light scatter and corneal backscatter between deep lamellar endothelial keratoplasty (DLEK) and penetrating keratoplasty (PK) for endothelial dysfunction...
  43. ncbi request reprint Comparison of corneal endothelial cell images from a noncontact specular microscope and a scanning confocal microscope
    Anna S Kitzmann
    Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Cornea 24:980-4. 2005
    ..We compared endothelial cell density (ECD) from images recorded by the ConfoScan 3 confocal microscope and a noncontact specular microscope...
  44. ncbi request reprint Keratocyte density: comparison of two confocal microscopes
    Jay W McLaren
    Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Eye Contact Lens 31:28-33. 2005
    ..In this study, we compared volumetric densities of stromal cells determined from images recorded by these two instruments...
  45. pmc Prostaglandin pathway gene therapy for sustained reduction of intraocular pressure
    Román A Barraza
    Department of Molecular Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Mol Ther 18:491-501. 2010
    ..This study provides the first gene therapy for correcting the main cause of glaucoma...
  46. ncbi request reprint Measuring corneal thickness with the ConfoScan 4 and z-ring adapter
    Jay W McLaren
    Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Eye Contact Lens 33:185-90. 2007
    ..To assess the precision and accuracy of the z-ring adapter with the ConfoScan 4 confocal microscope for measuring corneal thickness...
  47. pmc Long-term keratometric changes after penetrating keratoplasty for keratoconus and Fuchs Endothelial dystrophy
    Matthew E Raecker
    Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA
    Am J Ophthalmol 147:227-33. 2009
    ..To compare long-term keratometric changes after penetrating keratoplasty (PK) for keratoconus and Fuchs endothelial dystrophy...
  48. pmc Corneal subbasal nerve density: a comparison of two confocal microscopes
    Elizabeth A Erie
    Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905, USA
    Eye Contact Lens 34:322-5. 2008
    ..To compare subbasal nerve densities estimated from images recorded by the tandem scanning and the ConfoScan 4 confocal microscopes...
  49. ncbi request reprint Ascorbic acid content of human corneal epithelium
    R F Brubaker
    Department of Ophthalmology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Invest Ophthalmol Vis Sci 41:1681-3. 2000
    ..To measure the concentration of ascorbic acid in the human corneal epithelium...
  50. ncbi request reprint Prevalence of floppy eyelid syndrome in obstructive sleep apnea-hypopnea syndrome
    Randy A Karger
    Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Ophthalmology 113:1669-74. 2006
    ..To determine the prevalence of floppy eyelid syndrome (FES) in obstructive sleep apnea-hypopnea syndrome (OSAHS) and to develop a method to measure eyelid laxity...
  51. ncbi request reprint Retinopathy from a green laser pointer: a clinicopathologic study
    Dennis M Robertson
    Department of Ophthalmology, Mayo Clinic, Foundation and Medical School, 200 First Street SW, Rochester, MN 55905, USA
    Arch Ophthalmol 123:629-33. 2005
    ..To report retinopathy following exposure to light from a commercially available class 3A green laser pointer...