Research Topics
| J W McLarenSummaryAffiliation: Mayo Clinic Country: USA Publications
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Publications
Modeling the effect of forward scatter and aberrations on visual acuity after endothelial keratoplastyJay W McLaren
Department of Ophthalmology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Invest Ophthalmol Vis Sci 53:5545-51. 2012..To evaluate the effects on visual acuity of forward scatter and aberrations typical of those after Descemet stripping endothelial keratoplasty (DSEK)...
Standardization of corneal haze measurement in confocal microscopyJay W McLaren
Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA
Invest Ophthalmol Vis Sci 51:5610-6. 2010..Corneal stromal haze cannot be compared in longitudinal studies or across laboratories without standardization. In this study, a method was devised of standardizing image brightness in confocal microscopy of the cornea...
Corneal thickness measurement by confocal microscopy, ultrasound, and scanning slit methodsJay W McLaren
Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Am J Ophthalmol 137:1011-20. 2004..To measure corneal thickness by using a calibrated confocal microscope and to compare this measurement to thickness determined by ultrasonic and noncontact scanning slit pachymetry...- Effect of ibopamine on aqueous humor production in normotensive humansJay W McLaren
Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905, USA
Invest Ophthalmol Vis Sci 44:4853-8. 2003..Mydriasis can interfere with the measurement of aqueous flow. In this study ibopamine's effect on aqueous humor production was measured while making allowance for the potential artifact caused by its mydriatic effect... - Automated assessment of keratocyte density in clinical confocal microscopy of the corneal stromaJ W McLaren
Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
J Microsc 229:21-31. 2008..In these corneas, which showed a decrease in cell density after surgery, the program identified cells as well as human observers did... - Automated assessment of keratocyte density in stromal images from the ConfoScan 4 confocal microscopeJay W McLaren
Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA
Invest Ophthalmol Vis Sci 51:1918-26. 2010..The adaptation of our earlier cell-counting program to the ConfoScan 4 provides a timesaving, objective, and reproducible means of determining stromal cell densities in images from the ConfoScan 4... - Corneal reinnervation after LASIK: prospective 3-year longitudinal studyMartha P Calvillo
Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Invest Ophthalmol Vis Sci 45:3991-6. 2004..The numbers of subbasal nerves appear to decrease between 2 and 3 years after LASIK. The orientation of the regenerated subbasal nerves remains predominantly vertical... - Mechanism of ocular hypotensive action of bimatoprost (Lumigan) in patients with ocular hypertension or glaucomaGregory A Christiansen
Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA
Ophthalmology 111:1658-62. 2004..Bimatoprost had no significant effect on aqueous humor formation... - Mechanism of action of bimatoprost, latanoprost, and travoprost in healthy subjects. A crossover studyK Sheng Lim
Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA
Ophthalmology 115:790-795.e4. 2008..To study the effects of 3 prostaglandin analogs, bimatoprost, latanoprost, and travoprost, on aqueous dynamics in the same subjects and to compare techniques of assessing outflow facility... - Corneal wavefront errors 24 months after deep lamellar endothelial keratoplasty and penetrating keratoplastyJay W McLaren
Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905, USA
Am J Ophthalmol 147:959-65, 965.e1-2. 2009..To evaluate high-order aberrations (HOA) induced by the anterior corneal surface after deep lamellar endothelial keratoplasty (DLEK) and penetrating keratoplasty (PK)... - Keratocyte density of central human cornea after laser in situ keratomileusisKatsuya Mitooka
Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905, USA
Am J Ophthalmol 133:307-14. 2002..In the anterior flap, keratocyte density decreases 1 year after LASIK. The long-term effects of these cellular deficits, if any, require further study... - Keratocyte and subbasal nerve density after penetrating keratoplastySanjay V Patel
Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
Trans Am Ophthalmol Soc 105:180-9; discussion 189-90. 2007..To determine central keratocyte and subbasal nerve densities after penetrating keratoplasty (PK) in clear grafts and in grafts with late endothelial failure (LEF)... - Reinnervation in the cornea after LASIKBong Hwan Lee
Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA
Invest Ophthalmol Vis Sci 43:3660-4. 2002..During the first year after LASIK, subbasal nerve fiber bundles gradually return, although by 1 year their number remains less than half of that before LASIK... - Recovery of corneal subbasal nerve density after PRK and LASIKJay C Erie
Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, Minnesota
Am J Ophthalmol 140:1059-1064. 2005..CONCLUSION: Corneal subbasal nerve density does not recover to near preoperative densities until 5 years after LASIK, as compared with 2 years after PRK... - Confocal microscopy in vivo in corneas of long-term contact lens wearersSanjay V Patel
Department of Ophthalmology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
Invest Ophthalmol Vis Sci 43:995-1003. 2002..The temporal epithelium is thinner in corneas of long-term contact lens wearers than in control subjects. Decreased corneal sensitivity in contact lens wearers is not accompanied by decreased nerve fiber bundle density... - Corneal aberrations and visual acuity after laser in situ keratomileusis: femtosecond laser versus mechanical microkeratomeRamón Calvo
Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905, USA
Am J Ophthalmol 149:785-93. 2010..To compare corneal high-order aberrations and visual acuity after laser in situ keratomileusis (LASIK) with the flap created by a femtosecond laser (bladeless) to LASIK with the flap created by a mechanical microkeratome... - Long-term corneal keratoctye deficits after photorefractive keratectomy and laser in situ keratomileusisJay C Erie
Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
Trans Am Ophthalmol Soc 103:56-66; discussion 67-8. 2005..CONCLUSIONS: Keratocyte density is decreased in the anterior stroma after PRK and in the stromal flap and the retroablation zone after LASIK for up to 5 years. Posterior stromal keratocyte deficits are first noted at 5 years... - Comparison of effects of topical ibopamine and epinephrine on the circadian rhythm of intraocular pressure of the rabbit eye as measured by telemetryJ W McLaren
Department of Ophthalmology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA
J Ocul Pharmacol Ther 15:107-16. 1999..Since ibopamine is a pro-drug of deoxyepinephrine (N-methyl dopamine, epinine), its effects are assumed to be due to this metabolite, a metabolite that is structurally similar to epinephrine... - Host and graft thickness after Descemet stripping endothelial keratoplasty for Fuchs endothelial dystrophyKamran A Ahmed
Mayo Medical School, Mayo Clinic, Rochester, MN 55905, USA
Am J Ophthalmol 150:490-497.e2. 2010..To determine relationships between vision, forward scatter, and total corneal and graft thicknesses after Descemet stripping endothelial keratoplasty (DSEK)... - Analysis of postoperative glare and intraocular lens designJ C Erie
Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905, USA
J Cataract Refract Surg 27:614-21. 2001..To assess the potential for reflected glare images from commonly used intraocular lens (IOL) materials and designs... - The effect of age on the corneal subbasal nerve plexusJay C Erie
Department of Ophthalmology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
Cornea 24:705-9. 2005..To measure subbasal nerve density and orientation in normal human corneas across a broad age range... - Clinical responses of the corneal endotheliumWilliam M Bourne
Mayo Clinic, Department of Ophthalmology, 200 First Street SW, Rochester, MN 55905, USA
Exp Eye Res 78:561-72. 2004..We describe the clinical responses of the corneal endothelium to aging, drugs, glaucoma, contact lens wear, trauma, disease, and surgery... - Keratocyte density in the human cornea after photorefractive keratectomyJay C Erie
Department of Ophthalmology, Mayo Clinic, Rochester, Minn 55905, USA
Arch Ophthalmol 121:770-6. 2003..To perform a quantitative analysis of keratocyte density in human corneas after photorefractive keratectomy (PRK)... - The effect of corneal light scatter on vision after penetrating keratoplastySanjay V Patel
Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905, USA
Am J Ophthalmol 146:913-9. 2008..To determine the effect of corneal light scatter on vision after penetrating keratoplasty (PK)... - Effect of myopic laser in situ keratomileusis on epithelial and stromal thickness: a confocal microscopy studyJay C Erie
Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA
Ophthalmology 109:1447-52. 2002..To determine changes in central epithelial and stromal thickness in human corneas in vivo after laser in situ keratomileusis (LASIK)... - The effect of corneal light scatter on vision after descemet stripping with endothelial keratoplastySanjay V Patel
Department of Ophthalmology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
Arch Ophthalmol 127:153-60. 2009..To establish an association between corneal light scatter and vision after Descemet stripping with endothelial keratoplasty (DSEK)... - Confocal microscopy in ophthalmologyJay C Erie
Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905, USA
Am J Ophthalmol 148:639-46. 2009..To describe the principles, capabilities, and applications of confocal microscopy in vivo in ophthalmology... - Keratocyte density in keratoconus. A confocal microscopy study(a)Jay C Erie
Departments of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA
Am J Ophthalmol 134:689-95. 2002..41). CONCLUSION: Keratocyte density is decreased in the anterior and posterior stroma of keratoconus patients who wear contact lenses... - Comparison of flex-center, center, and corner methods of corneal endothelial cell analysisSanjay V Patel
Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905, USA
Cornea 29:1042-7. 2010..In this study, we examined agreement among the flex-center, center, and corner (standard) methods of endothelial analysis... - Subbasal nerve density and corneal sensitivity after laser in situ keratomileusis: femtosecond laser vs mechanical microkeratomeSanjay V Patel
Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905, USA
Arch Ophthalmol 128:1413-9. 2010..To compare changes in subbasal nerve density and corneal sensitivity after laser in situ keratomileusis (LASIK) with the flap created by a femtosecond laser (bladeless) vs a mechanical microkeratome... - Anterior keratocyte depletion in fuchs endothelial dystrophyLaura A Hecker
Department of Ophthalmology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
Arch Ophthalmol 129:555-61. 2011..To determine if keratocyte populations are different in corneas with Fuchs dystrophy compared with control corneas... - Circadian variation of aqueous dynamics in young healthy adultsArthur J Sit
Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905, USA
Invest Ophthalmol Vis Sci 49:1473-9. 2008..This study was undertaken to investigate whether changes in outflow facility, episcleral venous pressure, or uveoscleral flow at night could account for the nocturnal IOP... - Femtosecond laser versus mechanical microkeratome for LASIK: a randomized controlled studySanjay V Patel
Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
Ophthalmology 114:1482-90. 2007..To compare corneal haze (backscattered light) and visual outcomes between fellow eyes randomized to LASIK with the flap created by a femtosecond laser (bladeless) or with the flap created by a mechanical microkeratome... - Corneal keratocyte deficits after photorefractive keratectomy and laser in situ keratomileusisJay C Erie
Department of Ophthalmology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
Am J Ophthalmol 141:799-809. 2006..To measure changes in keratocyte density up to five years after photorefractive keratectomy (PRK) and laser in situ keratomileusis (LASIK)... - Effects of glaucoma medications on corneal endothelium, keratocytes, and subbasal nerves among participants in the ocular hypertension treatment studyKeith H Baratz
Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Cornea 25:1046-52. 2006..To compare subbasal corneal nerve and keratocyte density and endothelial characteristics of ocular hypertensive patients treated with medications or observation... - Objective measurement of backscattered light from the anterior and posterior cornea in vivoSanjay V Patel
Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Invest Ophthalmol Vis Sci 48:166-72. 2007..To develop an objective and repeatable method of measuring corneal backscattered light from different depths of the cornea in vivo... - Long-term keratocyte deficits in the corneal stroma after LASIKJay C Erie
Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905, USA
Ophthalmology 111:1356-61. 2004..To determine changes in keratocyte density up to 3 years after LASIK... - Confocal microscopy changes in epithelial and stromal thickness up to 7 years after LASIK and photorefractive keratectomy for myopiaSanjay V Patel
Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, Minn, USA
J Refract Surg 23:385-92. 2007..To determine the long-term changes in epithelial, stromal, and corneal thickness after LASIK and photorefractive keratectomy (PRK)... - Retinal image stability in head tremor and nystagmus: counterintuitive observationsBrian R Younge
Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905, USA
J Neuroophthalmol 27:107-14. 2007..Ophthalmoscopy of the fundus in a patient with head tremor is facilitated by image stability, whereas such observation of a patient with nystagmus is made difficult by image movement. Why does this occur?.. - Measurement of aqueous humor flowJay W McLaren
Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905, USA
Exp Eye Res 88:641-7. 2009..Studies of the production and circulation of aqueous humor have provided a basis for understanding the fundamental dynamics of the eye as well as understanding treatments for glaucoma... - Keratocyte density and recovery of subbasal nerves after penetrating keratoplasty and in late endothelial failureSanjay V Patel
Department of Ophthalmology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
Arch Ophthalmol 125:1693-8. 2007..To determine central keratocyte and subbasal nerve densities in clear and failed grafts after penetrating keratoplasty... - Scattered light and visual function in a randomized trial of deep lamellar endothelial keratoplasty and penetrating keratoplastySanjay V Patel
Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Am J Ophthalmol 145:97-105. 2008..To compare vision, intraocular forward light scatter and corneal backscatter between deep lamellar endothelial keratoplasty (DLEK) and penetrating keratoplasty (PK) for endothelial dysfunction... - Comparison of corneal endothelial cell images from a noncontact specular microscope and a scanning confocal microscopeAnna S Kitzmann
Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Cornea 24:980-4. 2005..If the proprietary software provided with the ConfoScan 3 is used, it should be manually corrected... - Keratocyte density: comparison of two confocal microscopesJay W McLaren
Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Eye Contact Lens 31:28-33. 2005..2 times greater with the ConfoScan 3. This difference must be considered when comparing results from studies that use one instrument with results from studies that use the other... - Prostaglandin pathway gene therapy for sustained reduction of intraocular pressureRomán A Barraza
Department of Molecular Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
Mol Ther 18:491-501. 2010..This study provides the first gene therapy for correcting the main cause of glaucoma... - Measuring corneal thickness with the ConfoScan 4 and z-ring adapterJay W McLaren
Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Eye Contact Lens 33:185-90. 2007..To assess the precision and accuracy of the z-ring adapter with the ConfoScan 4 confocal microscope for measuring corneal thickness... - Long-term keratometric changes after penetrating keratoplasty for keratoconus and Fuchs Endothelial dystrophyMatthew E Raecker
Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA
Am J Ophthalmol 147:227-33. 2009..To compare long-term keratometric changes after penetrating keratoplasty (PK) for keratoconus and Fuchs endothelial dystrophy... - Corneal subbasal nerve density: a comparison of two confocal microscopesElizabeth A Erie
Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905, USA
Eye Contact Lens 34:322-5. 2008..To compare subbasal nerve densities estimated from images recorded by the tandem scanning and the ConfoScan 4 confocal microscopes... - Ascorbic acid content of human corneal epitheliumR F Brubaker
Department of Ophthalmology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
Invest Ophthalmol Vis Sci 41:1681-3. 2000..To measure the concentration of ascorbic acid in the human corneal epithelium... - Prevalence of floppy eyelid syndrome in obstructive sleep apnea-hypopnea syndromeRandy A Karger
Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Ophthalmology 113:1669-74. 2006..Patients with subjectively easy upper lid eversion are at risk for OSAHS. By recognizing the potential for OSAHS in these patients, the ophthalmologist may play an important role in initiating their evaluation and treatment... - Retinopathy from a green laser pointer: a clinicopathologic studyDennis M Robertson
Department of Ophthalmology, Mayo Clinic, Foundation and Medical School, 200 First Street SW, Rochester, MN 55905, USA
Arch Ophthalmol 123:629-33. 2005..Histologic study showed RPE damage in the exposed subfoveal and parafoveal regions. CONCLUSION: A class 3A green laser pointer caused visible retinopathy in the human eye with exposures as short as 60 seconds...