Andrew McKeon

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. doi request reprint Striational antibodies in a paraneoplastic context
    Andrew McKeon
    Department of Medicine and Pathology, Mayo Clinic, Hilton 3 78, 200 First Street SW, Rochester, Minnesota 55905, USA
    Muscle Nerve 47:585-7. 2013
  2. doi request reprint Stiff-man syndrome and variants: clinical course, treatments, and outcomes
    Andrew McKeon
    Department of Neurology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Arch Neurol 69:230-8. 2012
  3. ncbi request reprint Potassium channel antibody associated encephalopathy presenting with a frontotemporal dementia like syndrome
    Andrew McKeon
    Department of Neurology, Mater Misericordiae University Hospital, Dublin, Ireland
    Arch Neurol 64:1528-30. 2007
  4. doi request reprint Paraneoplastic encephalomyelopathies: pathology and mechanisms
    Andrew McKeon
    Department of Laboratory Medicine and Pathology, Mayo Clinic, College of Medicine, Rochester, MN, 55905, USA
    Acta Neuropathol 122:381-400. 2011
  5. doi request reprint Purkinje cell cytoplasmic autoantibody type 1 accompaniments: the cerebellum and beyond
    Andrew McKeon
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Arch Neurol 68:1282-9. 2011
  6. doi request reprint Psychogenic tremor: long-term prognosis in patients with electrophysiologically confirmed disease
    Andrew McKeon
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Mov Disord 24:72-6. 2009
  7. doi request reprint Psychogenic tremor occurring after deep brain stimulation surgery for essential tremor
    Andrew McKeon
    Department of Neurology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA
    Neurology 70:1498-9. 2008
  8. doi request reprint The spectrum of disorders presenting as adult-onset focal lower extremity dystonia
    Andrew McKeon
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Parkinsonism Relat Disord 14:613-9. 2008
  9. ncbi request reprint The alcohol withdrawal syndrome
    A McKeon
    Department of Neurology and Clinical Neurosciences, Beaumont Hospital, Dublin, and Royal College of Surgeons in Ireland, Dublin, Ireland
    J Neurol Neurosurg Psychiatry 79:854-62. 2008
  10. ncbi request reprint Whole-body tremulousness: isolated generalized polymyoclonus
    Andrew McKeon
    Department of Neurology, Gonda 8 South, Mayo Clinic, 200 First St SW, Rochester, MN 55902, USA
    Arch Neurol 64:1318-22. 2007

Collaborators

Detail Information

Publications42

  1. doi request reprint Striational antibodies in a paraneoplastic context
    Andrew McKeon
    Department of Medicine and Pathology, Mayo Clinic, Hilton 3 78, 200 First Street SW, Rochester, Minnesota 55905, USA
    Muscle Nerve 47:585-7. 2013
    ..The clinical significance of striational antibodies (StrAbs) detected in the course of paraneoplastic antibody testing is unknown...
  2. doi request reprint Stiff-man syndrome and variants: clinical course, treatments, and outcomes
    Andrew McKeon
    Department of Neurology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Arch Neurol 69:230-8. 2012
    ..Little information is available about the incidence of stiff-man syndrome (SMS) (the classic form or its variants) or about long-term treatment responses and outcomes...
  3. ncbi request reprint Potassium channel antibody associated encephalopathy presenting with a frontotemporal dementia like syndrome
    Andrew McKeon
    Department of Neurology, Mater Misericordiae University Hospital, Dublin, Ireland
    Arch Neurol 64:1528-30. 2007
    ..To describe a patient who presented with features suggestive of frontotemporal dementia (FTD) but with some atypical findings and antibodies to neuronal voltage-gated potassium channels (VGKC-Abs)...
  4. doi request reprint Paraneoplastic encephalomyelopathies: pathology and mechanisms
    Andrew McKeon
    Department of Laboratory Medicine and Pathology, Mayo Clinic, College of Medicine, Rochester, MN, 55905, USA
    Acta Neuropathol 122:381-400. 2011
    ..Here we describe in detail the neuropathological findings and pathophysiology of paraneoplastic CNS disorders with reference to antigen-specific serology and neurological and oncological contexts...
  5. doi request reprint Purkinje cell cytoplasmic autoantibody type 1 accompaniments: the cerebellum and beyond
    Andrew McKeon
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Arch Neurol 68:1282-9. 2011
    ..To investigate the full extent of Purkinje cell cytoplasmic autoantibody type 1 autoimmunity (classically associated with paraneoplastic cerebellar degeneration) from clinical, immunohistochemical, and neuropathological perspectives...
  6. doi request reprint Psychogenic tremor: long-term prognosis in patients with electrophysiologically confirmed disease
    Andrew McKeon
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Mov Disord 24:72-6. 2009
    ..037). Physiologically-confirmed psychogenic tremor carries a poor prognosis, with unremitting or worse tremor persisting 3-years after diagnosis in most...
  7. doi request reprint Psychogenic tremor occurring after deep brain stimulation surgery for essential tremor
    Andrew McKeon
    Department of Neurology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA
    Neurology 70:1498-9. 2008
  8. doi request reprint The spectrum of disorders presenting as adult-onset focal lower extremity dystonia
    Andrew McKeon
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Parkinsonism Relat Disord 14:613-9. 2008
    ..Uncommonly, adult-onset dystonia is confined to one lower extremity. We sought to characterize the clinical spectrum associated with the presenting phenotype of lower limb dystonia including foot torsion...
  9. ncbi request reprint The alcohol withdrawal syndrome
    A McKeon
    Department of Neurology and Clinical Neurosciences, Beaumont Hospital, Dublin, and Royal College of Surgeons in Ireland, Dublin, Ireland
    J Neurol Neurosurg Psychiatry 79:854-62. 2008
    ..Although AWS may be complex, careful evaluation and available treatments should ensure safe detoxification for most patients...
  10. ncbi request reprint Whole-body tremulousness: isolated generalized polymyoclonus
    Andrew McKeon
    Department of Neurology, Gonda 8 South, Mayo Clinic, 200 First St SW, Rochester, MN 55902, USA
    Arch Neurol 64:1318-22. 2007
    ..Acquired generalized repetitive myoclonus may be mistaken for tremor. Distinguishing myoclonus has etiologic and therapeutic implications...
  11. ncbi request reprint Unusual compulsive behaviors primarily related to dopamine agonist therapy in Parkinson's disease and multiple system atrophy
    Andrew McKeon
    Department of Neurology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA
    Parkinsonism Relat Disord 13:516-9. 2007
    ....
  12. pmc Updated estimate of AQP4-IgG serostatus and disability outcome in neuromyelitis optica
    Yujuan Jiao
    From the Departments of Laboratory Medicine and Pathology Y J, J P F, V A L, A M L Q, A M, R I, S J P, Neurology V A L, A M, C C, B G W, C F L, S J P, Immunology V A L, and Health Sciences Research S M J, C Y S, College of Medicine, Mayo Clinic, Rochester, MN Department of Neurology D M W, College of Medicine, Mayo Clinic, Scottsdale, AZ and Department of Neurology E A S, College of Medicine, Mayo Clinic, Jacksonville, FL
    Neurology 81:1197-204. 2013
    ....
  13. doi request reprint Neuronal voltage-gated potassium channel complex autoimmunity in children
    Radhika Dhamija
    Department of Neurology, Mayo Clinic, Rochester, MN, USA
    Pediatr Neurol 44:275-81. 2011
    ..Currently 2.7% of pediatric sera evaluated for neurologic autoimmunity are positive for neuronal potassium channel complex-reactive immunoglobulin G. The frequency and full spectrum of neurologic accompaniments remains to be determined...
  14. pmc Autoimmune dementia: clinical course and predictors of immunotherapy response
    Eoin P Flanagan
    Department of Neurology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Mayo Clin Proc 85:881-97. 2010
    ..To define the diagnostic characteristics and predictors of treatment response in patients with suspected autoimmune dementia...
  15. pmc Autoimmune chorea in adults
    Orna O'Toole
    Department of Neurology, Mayo Clinic, College of Medicine, Rochester, MN, USA
    Neurology 80:1133-44. 2013
    ..To determine the characteristics of adult-onset autoimmune chorea, and compare paraneoplastic and idiopathic subgroups...
  16. doi request reprint Insights from LGI1 and CASPR2 potassium channel complex autoantibody subtyping
    Christopher J Klein
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
    JAMA Neurol 70:229-34. 2013
    ....
  17. pmc Autoimmune epilepsy: clinical characteristics and response to immunotherapy
    Amy M L Quek
    Department of Laboratory Medicine and Pathology, Mayo Clinic, College of Medicine, Rochester, MN 55905, USA
    Arch Neurol 69:582-93. 2012
    ..To describe clinical characteristics and immunotherapy responses in patients with autoimmune epilepsy...
  18. doi request reprint Psychiatric manifestations of voltage-gated potassium-channel complex autoimmunity
    Kristin J Somers
    Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, MN, USA
    J Neuropsychiatry Clin Neurosci 23:425-33. 2011
    ..Neuropsychiatric presentations were significantly associated with higher autoantibody values. Improvements were most evident in patients treated early, which emphasizes the need for early diagnosis and immunotherapy initiation...
  19. doi request reprint Reversible extralimbic paraneoplastic encephalopathies with large abnormalities on magnetic resonance images
    Andrew McKeon
    Department of Neurology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Arch Neurol 66:268-71. 2009
    ..To describe reversible extralimbic paraneoplastic encephalopathies with large, lobar lesions on magnetic resonance imaging (MRI)...
  20. doi request reprint Prediction of neuromyelitis optica attack severity by quantitation of complement-mediated injury to aquaporin-4-expressing cells
    Shannon R Hinson
    Department of Laboratory Medicine and Pathology, Hilton 3 78D, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Arch Neurol 66:1164-7. 2009
    ..The NMO-IgG binds in vitro to the extracellular domain of AQP4, activates complement, and causes astrocyte lesioning...
  21. doi request reprint Eculizumab in AQP4-IgG-positive relapsing neuromyelitis optica spectrum disorders: an open-label pilot study
    Sean J Pittock
    Department of Laboratory Medicine and Pathology, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55902, USA
    Lancet Neurol 12:554-62. 2013
    ..The aim of this study was to investigate the use of eculizumab--a therapeutic monoclonal IgG that neutralises the complement protein C5--in neuromyelitis optica spectrum disorders...
  22. pmc Effects of age and sex on aquaporin-4 autoimmunity
    Amy M L Quek
    Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Arch Neurol 69:1039-43. 2012
    ..To determine the sex and age distribution of aquaporin-4 (AQP4) autoimmunity using data derived from clinical service laboratory testing of 56,464 patient samples...
  23. doi request reprint Eliminating false-positive results in serum tests for neuromuscular autoimmunity
    Metha Apiwattanakul
    Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Muscle Nerve 41:702-4. 2010
    ..05% and 1.7% for AchR and VGKC autoantibodies, respectively. Specificity assurance in radioimmunoprecipitation assays requires subtraction of values for 125I-ligand binding...
  24. pmc GABAB receptor autoantibody frequency in service serologic evaluation
    Oliver J Jeffery
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN, USA
    Neurology 81:882-7. 2013
    ..We sought to determine in a diagnostic serology laboratory the frequency and accompaniments (neurologic, oncologic, and serologic) of GABABR-immunoglobulin G (IgG)...
  25. pmc Ganglionic acetylcholine receptor autoantibody: oncological, neurological, and serological accompaniments
    Andrew McKeon
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Arch Neurol 66:735-41. 2009
    ..To describe the clinical utility of the nicotinic ganglionic acetylcholine receptor (alpha3-AChR) autoantibody as a marker of neurological autoimmunity and cancer...
  26. pmc Glycine receptor autoimmune spectrum with stiff-man syndrome phenotype
    Andrew McKeon
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
    JAMA Neurol 70:44-50. 2013
    ....
  27. pmc Chronic pain as a manifestation of potassium channel-complex autoimmunity
    Christopher J Klein
    Department of Neurology, Mayo Clinic, Rochester, MN, USA
    Neurology 79:1136-44. 2012
    ..Autoantibodies targeting voltage-gated potassium channel (VGKC) complexes cause a spectrum of neuronal hyperexcitability disorders. We investigated pain as a manifestation of VGKC-complex autoimmunity...
  28. doi request reprint Parkinsonism and dropped head: dystonia, myopathy or both?
    Rodolfo Savica
    Department of Neurology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Parkinsonism Relat Disord 18:30-4. 2012
    ..The substrate for DHS is controversial, with some concluding that the cause is myopathic and others, exclusively dystonic. We report our clinical series of DHS arising in the setting of parkinsonism...
  29. doi request reprint Diagnosis of neuromyelitis spectrum disorders: comparative sensitivities and specificities of immunohistochemical and immunoprecipitation assays
    Andrew McKeon
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Arch Neurol 66:1134-8. 2009
    ....
  30. doi request reprint Intractable vomiting as the initial presentation of neuromyelitis optica
    Metha Apiwattanakul
    Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Ann Neurol 68:757-61. 2010
    ..Our clinical, pathologic and neuroimaging observations suggest the aquaporin-4-rich area postrema may be a first point of attack in neuromyelitis optica...
  31. doi request reprint Positron emission tomography-computed tomography in paraneoplastic neurologic disorders: systematic analysis and review
    Andrew McKeon
    Department of Neurology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Arch Neurol 67:322-9. 2010
    ..To evaluate the cancer detection rate of whole-body positron emission tomography-computed tomography (PET-CT) in a paraneoplastic neurologic context...
  32. doi request reprint Coexistence of myasthenia gravis and serological markers of neurological autoimmunity in neuromyelitis optica
    Andrew McKeon
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Muscle Nerve 39:87-90. 2009
    ..0001. The coexistence of NMO and MG should be considered in atypical or refractory presentations of either disorder...
  33. doi request reprint Extratemporal EEG and MRI findings in ANNA-1 (anti-Hu) encephalitis
    Leslie A Rudzinski
    Department of Neurology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Epilepsy Res 95:255-62. 2011
    ..The study objectives were to measure the rate of extratemporal abnormalities, and to determine the relative value of MRI and EEG in an ANNA-1 encephalitis cohort...
  34. doi request reprint Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS)
    Sean J Pittock
    Department of Neurology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Brain 133:2626-34. 2010
    ..The T cell predominant inflammatory pathology in affected central nervous system lesions and the clinical and radiological response to immunosuppressive therapies is consistent with an immune-mediated process...
  35. doi request reprint Paraneoplastic jaw dystonia and laryngospasm with antineuronal nuclear autoantibody type 2 (anti-Ri)
    Sean J Pittock
    Mayo Medical School College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Arch Neurol 67:1109-15. 2010
    ..However, the neurologic spectrum of ANNA-2 autoimmunity is broader, includes a syndrome of jaw dystonia and laryngospasm, and can be accompanied by lung carcinoma...
  36. doi request reprint Sleep manifestations of voltage-gated potassium channel complex autoimmunity
    Jason R Cornelius
    Center for Sleep Medicine, College of Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Arch Neurol 68:733-8. 2011
    ..To identify the spectrum of sleep disorders associated with autoantibodies reactive with voltage-gated potassium channel (VGKC) complexes...
  37. ncbi request reprint Autoimmune encephalopathies and epilepsies in children and teenagers
    Lily C Wong-Kisiel
    Division of Child and Adolescent Neurology, Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Can J Neurol Sci 39:134-44. 2012
    ..This review summarizes the clinical presentations and recommended evaluations and treatment of pediatric epileptic encephalopathy suspected to be of autoimmune etiology...
  38. doi request reprint Teaching NeuroImages: PET-CT hypermetabolism paralleling muscle hyperactivity in stiff-person syndrome
    Orna O'Toole
    From the Departments of Neurology O O, J A T, A M, Laboratory Medicine and Pathology O O, A M, and Radiology R M, Mayo Clinic College of Medicine, Rochester, MN
    Neurology 80:e109. 2013
    ..No malignancy was detected...
  39. ncbi request reprint Seizure versus syncope
    Andrew McKeon
    Department of Neurology, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland
    Lancet Neurol 5:171-80. 2006
    ..Despite a careful and thorough approach to the patient with a "seizure versus syncope" problem, many will require repeated assessment before a diagnosis is made...
  40. ncbi request reprint Heterogeneity of presentation and outcome in the Irish rapid-onset dystonia-parkinsonism kindred
    Andrew McKeon
    Department of Neurology, Beaumont Hospital Dublin and Royal College of Surgeons in Ireland, Dublin, Ireland
    Mov Disord 22:1325-7. 2007
    ..The broad phenotypic spectrum of RDP described in the text and detailed in the video, should be considered when evaluating patients with dystonia...
  41. doi request reprint Azathioprine: tolerability, efficacy, and predictors of benefit in neuromyelitis optica
    C Costanzi
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Neurology 77:659-66. 2011
    ..To evaluate the efficacy, tolerability, optimal dosing, and monitoring of azathioprine in patients with neuromyelitis optica (NMO)...
  42. ncbi request reprint Postanoxic delayed-onset cerebellar syndrome
    Andrew McKeon
    J Neurol 254:1304-5. 2007