Carlos B Mantilla

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Targeted delivery of TrkB receptor to phrenic motoneurons enhances functional recovery of rhythmic phrenic activity after cervical spinal hemisection
    Heather M Gransee
    Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 8:e64755. 2013
  2. ncbi request reprint Convergence of pattern generator outputs on a common mechanism of diaphragm motor unit recruitment
    Carlos B Mantilla
    Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester MN, USA Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN, USA Electronic address
    Prog Brain Res 209:309-29. 2014
  3. pmc Impact of diaphragm muscle fiber atrophy on neuromotor control
    Carlos B Mantilla
    Department of Physiology and Biomedical Engineering, Mayo Clinic, College of Medicine, 200 First Street SW, Rochester, MN 55905, USA Department of Anesthesiology, Mayo Clinic, College of Medicine, 200 First Street SW, Rochester, MN 55905, USA Electronic address
    Respir Physiol Neurobiol 189:411-8. 2013
  4. pmc Motoneuron BDNF/TrkB signaling enhances functional recovery after cervical spinal cord injury
    Carlos B Mantilla
    Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA
    Exp Neurol 247:101-9. 2013
  5. pmc Prolonged C2 spinal hemisection-induced inactivity reduces diaphragm muscle specific force with modest, selective atrophy of type IIx and/or IIb fibers
    Carlos B Mantilla
    Department of Anesthesiology, Mayo Clinic, Collegeof Medicine, Rochester, MN, USA
    J Appl Physiol (1985) 114:380-6. 2013
  6. pmc Phrenic motoneuron expression of serotonergic and glutamatergic receptors following upper cervical spinal cord injury
    Carlos B Mantilla
    Department of Physiology and Biomedical Engineering, College of Medicine, Mayo Clinic, Rochester MN 55905, USA
    Exp Neurol 234:191-9. 2012
  7. doi request reprint Developmental effects on myonuclear domain size of rat diaphragm fibers
    Carlos B Mantilla
    Department of Physiology and Biomedical Engineering 4 184 W Joseph SMH, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    J Appl Physiol (1985) 104:787-94. 2008
  8. pmc Phrenic motor unit recruitment during ventilatory and non-ventilatory behaviors
    Carlos B Mantilla
    Department of Anesthesiology, College of Medicine, Mayo Clinic, Rochester, MN 55905, United States
    Respir Physiol Neurobiol 179:57-63. 2011
  9. ncbi request reprint Frequency of myocardial infarction, pulmonary embolism, deep venous thrombosis, and death following primary hip or knee arthroplasty
    Carlos B Mantilla
    Department of Anesthesiology, Health Sciences Research, and Orthopedic Surgery, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Anesthesiology 96:1140-6. 2002
  10. ncbi request reprint Key aspects of phrenic motoneuron and diaphragm muscle development during the perinatal period
    Carlos B Mantilla
    Dept of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA
    J Appl Physiol (1985) 104:1818-27. 2008

Collaborators

Detail Information

Publications67

  1. pmc Targeted delivery of TrkB receptor to phrenic motoneurons enhances functional recovery of rhythmic phrenic activity after cervical spinal hemisection
    Heather M Gransee
    Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 8:e64755. 2013
    ....
  2. ncbi request reprint Convergence of pattern generator outputs on a common mechanism of diaphragm motor unit recruitment
    Carlos B Mantilla
    Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester MN, USA Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN, USA Electronic address
    Prog Brain Res 209:309-29. 2014
    ..In contrast, widely distributed inputs to phrenic motoneurons from various pattern generators (e.g., for breathing, coughing, or vocalization) would dictate recruitment order based on intrinsic electrophysiological properties. ..
  3. pmc Impact of diaphragm muscle fiber atrophy on neuromotor control
    Carlos B Mantilla
    Department of Physiology and Biomedical Engineering, Mayo Clinic, College of Medicine, 200 First Street SW, Rochester, MN 55905, USA Department of Anesthesiology, Mayo Clinic, College of Medicine, 200 First Street SW, Rochester, MN 55905, USA Electronic address
    Respir Physiol Neurobiol 189:411-8. 2013
    ..This review will examine neuromotor control of respiratory muscles such as the diaphragm muscle and the impact of muscle fiber atrophy on motor performance. ..
  4. pmc Motoneuron BDNF/TrkB signaling enhances functional recovery after cervical spinal cord injury
    Carlos B Mantilla
    Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA
    Exp Neurol 247:101-9. 2013
    ..These results indicate that BDNF/TrkB signaling in phrenic motoneuron pool plays a critical role in functional recovery after cervical spinal cord injury. ..
  5. pmc Prolonged C2 spinal hemisection-induced inactivity reduces diaphragm muscle specific force with modest, selective atrophy of type IIx and/or IIb fibers
    Carlos B Mantilla
    Department of Anesthesiology, Mayo Clinic, Collegeof Medicine, Rochester, MN, USA
    J Appl Physiol (1985) 114:380-6. 2013
    ..These data indicate that reduced specific force following prolonged inactivity of the DIAm is associated with modest, fiber type selective adaptations in muscle fiber size and fiber type distribution...
  6. pmc Phrenic motoneuron expression of serotonergic and glutamatergic receptors following upper cervical spinal cord injury
    Carlos B Mantilla
    Department of Physiology and Biomedical Engineering, College of Medicine, Mayo Clinic, Rochester MN 55905, USA
    Exp Neurol 234:191-9. 2012
    ..By providing information on the neuroplasticity of receptors expressed in a motoneuron pool that is inactivated by a higher-level spinal cord injury, appropriate pharmacological targets can be identified to alter motoneuron excitability...
  7. doi request reprint Developmental effects on myonuclear domain size of rat diaphragm fibers
    Carlos B Mantilla
    Department of Physiology and Biomedical Engineering 4 184 W Joseph SMH, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    J Appl Physiol (1985) 104:787-94. 2008
    ..These results suggest that MND size is not maintained during the considerable fiber growth associated with postnatal development of the Diam...
  8. pmc Phrenic motor unit recruitment during ventilatory and non-ventilatory behaviors
    Carlos B Mantilla
    Department of Anesthesiology, College of Medicine, Mayo Clinic, Rochester, MN 55905, United States
    Respir Physiol Neurobiol 179:57-63. 2011
    ..Activation of fast-twitch fatigable motor units only becomes necessary when accomplishing tasks that require greater force generation by the diaphragm muscle, e.g., sneezing and coughing...
  9. ncbi request reprint Frequency of myocardial infarction, pulmonary embolism, deep venous thrombosis, and death following primary hip or knee arthroplasty
    Carlos B Mantilla
    Department of Anesthesiology, Health Sciences Research, and Orthopedic Surgery, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Anesthesiology 96:1140-6. 2002
    ....
  10. ncbi request reprint Key aspects of phrenic motoneuron and diaphragm muscle development during the perinatal period
    Carlos B Mantilla
    Dept of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA
    J Appl Physiol (1985) 104:1818-27. 2008
    ....
  11. pmc Neuromuscular adaptations to respiratory muscle inactivity
    Carlos B Mantilla
    Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, United States
    Respir Physiol Neurobiol 169:133-40. 2009
    ....
  12. ncbi request reprint Risk factors for clinically relevant pulmonary embolism and deep venous thrombosis in patients undergoing primary hip or knee arthroplasty
    Carlos B Mantilla
    Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA
    Anesthesiology 99:552-60; discussion 5A. 2003
    ..The aim of this study was to examine the risk factors for clinically relevant pulmonary embolism and deep venous thrombosis after elective primary hip or knee arthroplasty in a large patient population...
  13. pmc Retrograde labeling of phrenic motoneurons by intrapleural injection
    Carlos B Mantilla
    Department of Physiology and Biomedical Engineering, Mayo Clinic, USA
    J Neurosci Methods 182:244-9. 2009
    ..This novel method is ideally suited for morphological studies and analyses of mRNA expression in isolated phrenic motoneurons using techniques such as laser capture microdissection...
  14. pmc Trophic factor expression in phrenic motor neurons
    Carlos B Mantilla
    Department of Anesthesiology, Mayo Clinic, 4 184 W Joseph SMH, 200 First St SW, Rochester, MN 55905, USA
    Respir Physiol Neurobiol 164:252-62. 2008
    ..This review will focus on the contribution of trophic factors to the establishment and maintenance of motor unit diversity in the DIAm, during development and in response to injury or disease...
  15. pmc The novel TrkB receptor agonist 7,8-dihydroxyflavone enhances neuromuscular transmission
    Carlos B Mantilla
    Department of Anesthesiology, College of Medicine, Mayo Clinic, 200 First Street SW, Joseph 4W 184F, Rochester, Minnesota 55905, USA
    Muscle Nerve 45:274-6. 2012
    ..The small molecule 7,8-DHF may constitute a novel therapy to improve neuromuscular function...
  16. ncbi request reprint Denervation effects on myonuclear domain size of rat diaphragm fibers
    Bharathi Aravamudan
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Appl Physiol 100:1617-22. 2006
    ..These results suggest that MND is not maintained after DNV-induced DIAm fiber hypertrophy or atrophy. These results are interpreted with respect to consequent effects of DNV on myonuclear transcriptional activity and protein turnover...
  17. doi request reprint Perioperative nerve injury after total hip arthroplasty: regional anesthesia risk during a 20-year cohort study
    Adam K Jacob
    Department of Anesthesiology, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Anesthesiology 115:1172-8. 2011
    ..Regional anesthesia (RA) techniques may increase the risk of neurologic injury. Using a retrospective cohort study, the authors tested the hypothesis that use of RA increases the risk for PNI after elective THA...
  18. ncbi request reprint Safety factor for neuromuscular transmission at type-identified diaphragm fibers
    Leonid G Ermilov
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 First Street SW, Joseph 4 184W, Rochester, Minnesota 55905, USA
    Muscle Nerve 35:800-3. 2007
    ..Fiber-type differences in activation history or mechanical load may contribute to differences in SF and are important determinants of neuromuscular plasticity...
  19. ncbi request reprint Neurotrophins improve neuromuscular transmission in the adult rat diaphragm
    Carlos B Mantilla
    Department of Anesthesiology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    Muscle Nerve 29:381-6. 2004
    ..Neurotrophins may constitute a novel therapeutic target to improve neuromuscular function in the diaphragm...
  20. pmc Non-stationarity and power spectral shifts in EMG activity reflect motor unit recruitment in rat diaphragm muscle
    Yasin B Seven
    Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA
    Respir Physiol Neurobiol 185:400-9. 2013
    ..In conclusion, non-stationarity of DIAm EMG reflects the period of motor unit recruitment, while a shift in the PSD towards higher frequencies reflects recruitment of more fatigable fast-twitch motor units...
  21. ncbi request reprint Smoking and chronic pain: a real-but-puzzling relationship
    Toby N Weingarten
    Mayo Clinic, USA
    Minn Med 94:35-7. 2011
    ..This article describes some of what they and others have discovered in recent years about the interactions between smoking and chronic pain...
  22. pmc Diaphragm motor unit recruitment in rats
    Carlos B Mantilla
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Respir Physiol Neurobiol 173:101-6. 2010
    ..A model for DIAm motor unit recruitment predicted that ventilatory behaviors would require activation of only fatigue resistant units...
  23. pmc Chronic assessment of diaphragm muscle EMG activity across motor behaviors
    Carlos B Mantilla
    Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA
    Respir Physiol Neurobiol 177:176-82. 2011
    ..By quantitatively determining the reliability of longitudinal diaphragm EMG analyses, we provide an important tool for evaluating the progression of diseases or injuries that impair ventilation...
  24. pmc Chronic postthoracotomy pain and health-related quality of life
    Michelle A O Kinney
    Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann Thorac Surg 93:1242-7. 2012
    ..Pain after thoracotomy is common. The objective of this study was to assess whether pain 3 months postthoracotomy negatively impacts quality of life...
  25. pmc Diaphragm muscle sarcopenia in aging mice
    Sarah M Greising
    Department of Physiology and Biomedical Engineering, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Exp Gerontol 48:881-7. 2013
    ..Sarcopenia may limit the ability of the DIAm to accomplish expulsive, non-ventilatory behaviors essential for airway clearance. As a result, these changes in the DIAm may contribute to respiratory complications with aging...
  26. doi request reprint Respiratory muscle plasticity
    Heather M Gransee
    Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA
    Compr Physiol 2:1441-62. 2012
    ....
  27. pmc Role of neurotrophins in recovery of phrenic motor function following spinal cord injury
    Gary C Sieck
    Departments of Physiology and Biomedical Engineering and Anesthesiology, Mayo Clinic, Rochester, MN 55905, United States
    Respir Physiol Neurobiol 169:218-25. 2009
    ....
  28. ncbi request reprint Mechanisms underlying myosin heavy chain expression during development of the rat diaphragm muscle
    Paige C Geiger
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    J Appl Physiol 101:1546-55. 2006
    ..Knowledge of isoform-specific MHC mRNA expression only yields predictive information on MHC protein expression for the MHC(Neo) isoform...
  29. doi request reprint Associations between heat pain perception and pain severity among patients with chronic pain
    W Michael Hooten
    Department of Anesthesiology, Mayo Clinic College ofMedicine, Rochester, Minnesota 55902, USA
    Pain Med 11:1554-63. 2010
    ....
  30. ncbi request reprint Synaptic vesicle distribution and release at rat diaphragm neuromuscular junctions
    Katharine L Rowley
    Department of Physiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Neurophysiol 98:478-87. 2007
    ..Differences in QC decline likely reflect fiber-type specific differences in activation history and correspond with well-described differences in neuromuscular transmission across muscle fiber types...
  31. doi request reprint Perioperative nerve injury after total shoulder arthroplasty: assessment of risk after regional anesthesia
    Hans P Sviggum
    Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA
    Reg Anesth Pain Med 37:490-4. 2012
    ..The objective of this large-scale, single-institution cohort study was to test the hypothesis that the use of ISB increases the risk for PNI after elective TSA...
  32. pmc Structure-activity relationships in rodent diaphragm muscle fibers vs. neuromuscular junctions
    Dylan C Sieck
    Department of Anesthesiology, College of Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Respir Physiol Neurobiol 180:88-96. 2012
    ....
  33. pmc Intracellular signaling pathways regulating net protein balance following diaphragm muscle denervation
    Heather M Argadine
    Department of Physiology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Physiol Cell Physiol 300:C318-27. 2011
    ..No single trigger is responsible for protein balance following DNV. Protein balance in skeletal muscle depends on multiple synthetic/degradation pathways that should be studied in concert...
  34. ncbi request reprint EMG-based detection of inspiration in the rat diaphragm muscle
    Douglas E Dow
    Departmernt of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Conf Proc IEEE Eng Med Biol Soc 1:1204-7. 2006
    ....
  35. pmc Systems biology of skeletal muscle: fiber type as an organizing principle
    Sarah M Greising
    Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA
    Wiley Interdiscip Rev Syst Biol Med 4:457-73. 2012
    ..This review uses fiber type classification as an organizing and simplifying principle to explore the complex interactions between the major proteins involved in muscle force generation and contraction...
  36. ncbi request reprint Denervation-induced changes in myosin heavy chain expression in the rat diaphragm muscle
    Paige C Geiger
    Department of Physiology and Biophysics, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Appl Physiol 95:611-9. 2003
    ..The time course of the changes in MHC isoform mRNA and protein expression suggests a predominant effect of altered protein turnover rates on MHC protein expression instead of altered transcription after Dnv...
  37. ncbi request reprint Respiratory muscle plasticity
    Katharine L Rowley
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 First St SW, Joseph 4 184W, Rochester, MN 55905, USA
    Respir Physiol Neurobiol 147:235-51. 2005
    ....
  38. pmc The effect of denervation on protein synthesis and degradation in adult rat diaphragm muscle
    Heather M Argadine
    Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA
    J Appl Physiol (1985) 107:438-44. 2009
    ..Early loss of contractile proteins, such as myosin heavy chain, is likely the result of selective protein degradation rather than generalized protein breakdown. Future studies should evaluate this selective effect of DNV...
  39. pmc Impairment of diaphragm muscle force and neuromuscular transmission after normothermic cardiopulmonary bypass: effect of low-dose inhaled CO
    Leonid G Ermilov
    Department of Anesthesthesiology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Am J Physiol Regul Integr Comp Physiol 298:R784-9. 2010
    ..Further studies are needed to ascertain the underlying mechanisms of CPB-induced neuromuscular dysfunction and to establish the potential role of CO therapy...
  40. pmc Novel method for transdiaphragmatic pressure measurements in mice
    Sarah M Greising
    Department of Physiology and Biomedical Engineering, Mayo Clinic, College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Respir Physiol Neurobiol 188:56-9. 2013
    ..161). This study establishes a novel method to determine Pdi across a range of DIAm behaviors in mice that may be useful in evaluating conditions associated with reduced ability to perform expulsive, non-ventilatory behaviors. ..
  41. ncbi request reprint Regulation of neuromuscular transmission by neurotrophins
    Wen Zhi Zhan
    Department of Anesthesiology, Mayo Clinic and Foundation Rochester, MN 55905, USA
    Sheng Li Xue Bao 55:617-24. 2003
    ..We review recent studies on the regulation of neuromuscular transmission, the motor unit-specific properties of NMJs and the effects of neurotrophins on synaptic efficacy at the NMJ...
  42. pmc Reduced ribosomal protein s6 phosphorylation after progressive resistance exercise in growing adolescent rats
    Nathan J Hellyer
    Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, Minnesota, USA
    J Strength Cond Res 26:1657-66. 2012
    ..05). We conclude that moderate intensity PRE is sufficient to induce muscle hypertrophy in adolescent animals, whereas the signaling mechanisms associated with muscle hypertrophy may differ between growing adolescents and adults...
  43. pmc Preoperative gabapentin for acute post-thoracotomy analgesia: a randomized, double-blinded, active placebo-controlled study
    Michelle A O Kinney
    Department of Anesthesiology, College of Medicine Mayo Clinic, Rochester, Minnesota, USA
    Pain Pract 12:175-83. 2012
    ..Patients undergoing thoracotomy benefit from epidural analgesia but still may experience significant postoperative pain. We examined the effect of preoperative gabapentin in thoracotomy patients...
  44. doi request reprint Smoking and pain: pathophysiology and clinical implications
    Yu Shi
    Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota, USA
    Anesthesiology 113:977-92. 2010
    ....
  45. ncbi request reprint Invited review: Mechanisms underlying motor unit plasticity in the respiratory system
    Carlos B Mantilla
    Department of Anesthesiology, Mayo Medical School, Rochester Minnesota 55905, USA
    J Appl Physiol 94:1230-41. 2003
    ..The role of activity, neurotrophins, and other growth factors in modulating this adaptability is discussed...
  46. ncbi request reprint Synaptic vesicle cycling at type-identified diaphragm neuromuscular junctions
    Carlos B Mantilla
    Department of Anesthesiology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, Minnesota 55905, USA
    Muscle Nerve 30:774-83. 2004
    ..Muscle fiber type-specific adaptations should be considered when examining neuromuscular disorders...
  47. pmc Inhaled carbon monoxide attenuates myocardial inflammatory cytokine expression in a rat model of cardiopulmonary bypass
    Juan N Pulido
    Department of Anesthesiology, Mayo Clinic College of Medicine, Saint Mary s Hospital, Rochester, Minnesota 55905, USA
    J Extra Corpor Technol 43:137-43. 2011
    ..Further investigation in a survival model of CPB is warranted...
  48. pmc Neuregulin-1 at synapses on phrenic motoneurons
    Amine N Issa
    Department of Physiology and Biomedical Engineering, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Comp Neurol 518:4213-25. 2010
    ..Overall, 26% ± 6% of NRG1 synapses are VGLUT2 immunoreactive. These findings provide the first evidence suggesting that NRG1 may modulate synaptic activity in adult motor systems...
  49. ncbi request reprint Neuregulin-dependent protein synthesis in C2C12 myotubes and rat diaphragm muscle
    Nathan J Hellyer
    Department of Physiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Am J Physiol Cell Physiol 291:C1056-61. 2006
    ..The results of the present study support the hypothesis that nerve-derived NRG contributes to the regulation of skeletal muscle mass by increasing protein synthesis via activation of PI3K...
  50. doi request reprint Neuromotor control in chronic obstructive pulmonary disease
    Carlos B Mantilla
    Department of Physiology and Biomedical Engineering, Mayo Clinic, College of Medicine, Rochester, Minnesota 55905, USA
    J Appl Physiol (1985) 114:1246-52. 2013
    ..Future studies should address how plasticity in motor units can be harnessed to mitigate the functional impact of COPD-induced changes...
  51. pmc Have bilateral total knee arthroplasties become safer? A population-based trend analysis
    Stavros G Memtsoudis
    Department of Anesthesiology, Hospital for Special Surgery, Weill Medical College of Cornell University, 535 East 70th Street, New York, NY 10021, USA
    Clin Orthop Relat Res 471:17-25. 2013
    ..It remains unclear whether this development has reduced overall perioperative morbidity and mortality...
  52. doi request reprint Perioperative nerve injury after total knee arthroplasty: regional anesthesia risk during a 20-year cohort study
    Adam K Jacob
    Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Anesthesiology 114:311-7. 2011
    ..The objective of this study was to test the hypothesis that PNI risk differs among patients according to RA use during TKA...
  53. doi request reprint Risk for perioperative myocardial infarction and mortality in patients undergoing hip or knee arthroplasty: the role of anemia
    Carlos B Mantilla
    Department of Anesthesiology, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Transfusion 51:82-91. 2011
    ..This study was designed to determine whether preoperative anemia represents an independent risk factor for 30-day mortality and nonfatal myocardial infarction (death/MI) in patients undergoing major orthopedic arthroplasty surgery...
  54. ncbi request reprint Neurotrophin effects on intracellular Ca2+ and force in airway smooth muscle
    Y S Prakash
    Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Am J Physiol Lung Cell Mol Physiol 291:L447-56. 2006
    ..These novel data demonstrate that neurotrophins influence ASM [Ca(2+)](i) and force regulation and suggest a potential role for neurotrophins in airway diseases...
  55. doi request reprint Dual-epidural catheter technique and perioperative outcomes after Ivor-Lewis esophagectomy
    Michael J Brown
    Department of Anesthesiology and Division of Thoracic Surgery, Mayo Clinic, Rochester, MN 55905, USA
    Reg Anesth Pain Med 38:3-8. 2013
    ..Ivor-Lewis esophagectomy is associated with significant postoperative analgesic requirements and perioperative complications. A dual-epidural technique may improve perioperative outcomes compared with single thoracic epidural analgesia...
  56. doi request reprint Nonalcoholic steatohepatitis in bariatric patients with a diagnosis of obstructive sleep apnea
    Toby N Weingarten
    Department of Anesthesiology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Obes Facts 5:587-96. 2012
    ..To study a possible association between obstructive sleep apnea (OSA) severity, managed with noninvasive ventilation, and nonalcoholic steatohepatitis (NASH) in bariatric surgical patients...
  57. ncbi request reprint Determination of the particulate size and aggregation of clonidine and corticosteroids for epidural steroid injection
    Halena M Gazelka
    Mayo Clinic, Rochester, MN, USA
    Pain Physician 15:87-93. 2012
    ..The combination of corticosteroid and clonidine is an intriguing, yet unstudied, alternative to traditional treatment...
  58. ncbi request reprint Optimizing conditions and avoiding pitfalls for prolonged axonal tracing with carbocyanine dyes in fixed rat spinal cords
    Bingkun K Chen
    Neuroscience Research Program and Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Neurosci Methods 154:256-63. 2006
    ..Our data suggested that higher temperature facilitated dye diffusion along the axons, and demonstrated that with caution DiI and DiO could be used as specific tracers in the same spinal cords...
  59. doi request reprint Associations between heat pain perception and opioid dose among patients with chronic pain undergoing opioid tapering
    W Michael Hooten
    Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, Minnesota 55902, USA
    Pain Med 11:1587-98. 2010
    ....
  60. pmc Neurotrophins in lung health and disease
    Ys Prakash
    Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Expert Rev Respir Med 4:395-411. 2010
    ..In this review, we describe the current status of our understanding of NT signaling in the lung, with hopes of using aspects of the NT signaling pathway in the diagnosis and therapy of lung diseases...
  61. doi request reprint Mechanical properties of respiratory muscles
    Gary C Sieck
    Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota
    Compr Physiol 3:1553-67. 2013
    ..Conditions that affect respiratory muscle performance may have a range of underlying pathophysiological causes, but their manifestations will depend on their impact on these basic elemental structures...
  62. ncbi request reprint Differential inhibition of neuronal Na+-Ca2+ exchange versus store-operated Ca2+ channels by volatile anesthetics in pheochromocytoma (PC12) cells
    Binnaz Ay
    Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Anesthesiology 103:93-101. 2005
    ....
  63. ncbi request reprint Effect of neurolytic celiac plexus block on pain relief, quality of life, and survival in patients with unresectable pancreatic cancer: a randomized controlled trial
    Gilbert Y Wong
    Department of Anesthesiology and Division of Pain Medicine, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    JAMA 291:1092-9. 2004
    ..Pancreatic cancer is an aggressive tumor associated with high mortality. Optimal pain control may improve quality of life (QOL) for these patients...
  64. ncbi request reprint The role of cyclic-ADP-ribose-signaling pathway in oxytocin-induced Ca2+ transients in human myometrium cells
    Hosana Barata
    Signal Transduction Laboratory, Department of Anesthesiology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Endocrinology 145:881-9. 2004
    ....
  65. ncbi request reprint Influence of corticosteroids on myonuclear domain size in the rat diaphragm muscle
    A Jeroen Verheul
    Department of Pulmonary Diseases, University Medical Center Nijmegen, 6500 HB Nijmegen, The Netherlands
    J Appl Physiol 97:1715-22. 2004
    ..Thus little, if any, loss of myonuclei was associated with CoS-induced atrophy of MHC2X or MHC2B DIAm fibers. In summary, MND size does not appear to be regulated during CoS-induced DIAm atrophy...
  66. ncbi request reprint In response to Point:Counterpoint: "Satellite cell addition is/is not obligatory for skeletal muscle hypertrophy"
    Carlos B Mantilla
    J Appl Physiol 103:1104. 2007
  67. doi request reprint Effect of mechanical ventilation on the diaphragm
    Gary C Sieck
    N Engl J Med 358:1392-4. 2008