Mary M Machulda

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. ncbi request reprint Mayo's Older Americans Normative Studies: Visual Form Discrimination and copy trial of the Rey-Osterrieth Complex Figure
    M M Machulda
    Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA
    J Clin Exp Neuropsychol 29:377-84. 2007
  2. pmc Identification of an atypical variant of logopenic progressive aphasia
    Mary M Machulda
    Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, United States Electronic address
    Brain Lang 127:139-44. 2013
  3. pmc Functional magnetic resonance imaging changes in amnestic and nonamnestic mild cognitive impairment during encoding and recognition tasks
    Mary M Machulda
    Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Int Neuropsychol Soc 15:372-82. 2009
  4. pmc Effect of APOE ε4 status on intrinsic network connectivity in cognitively normal elderly subjects
    Mary M Machulda
    Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA
    Arch Neurol 68:1131-6. 2011
  5. pmc Elevated occipital β-amyloid deposition is associated with widespread cognitive impairment in logopenic progressive aphasia
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA
    J Neurol Neurosurg Psychiatry 84:1357-64. 2013
  6. pmc Practice effects and longitudinal cognitive change in normal aging vs. incident mild cognitive impairment and dementia in the Mayo Clinic Study of Aging
    Mary M Machulda
    a Department of Psychiatry and Psychology, College of Medicine, Mayo Clinic, Rochester, MN, USA
    Clin Neuropsychol 27:1247-64. 2013
  7. pmc Microbleeds in the logopenic variant of primary progressive aphasia
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, MN, USA Electronic address
    Alzheimers Dement 10:62-6. 2014
  8. pmc Distinct regional anatomic and functional correlates of neurodegenerative apraxia of speech and aphasia: an MRI and FDG-PET study
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
    Brain Lang 125:245-52. 2013
  9. pmc Syndromes dominated by apraxia of speech show distinct characteristics from agrammatic PPA
    Keith A Josephs
    Department of Neurology Behavioral Neurology, Mayo Clinic, Rochester, MN, USA
    Neurology 81:337-45. 2013
  10. pmc Head trauma and in vivo measures of amyloid and neurodegeneration in a population-based study
    Michelle M Mielke
    From the Divisions of Epidemiology M M Mielke, R O R, R C P, Y E G and Biomedical Statistics and Informatics H J W, S D W, Department of Health Sciences Research Departments of Neurology R S, D S K, R O R, R C P, Psychiatry and Psychology M M Machulda, and Radiology P V, V J L, C R J, Mayo Clinic, Rochester, MN and Departments of Psychiatry, Psychology, and Neurology Y E G, Mayo Clinic, Scottsdale, AZ
    Neurology 82:70-6. 2014

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Mayo's Older Americans Normative Studies: Visual Form Discrimination and copy trial of the Rey-Osterrieth Complex Figure
    M M Machulda
    Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA
    J Clin Exp Neuropsychol 29:377-84. 2007
    ..Limitations and unique features of the MOANS normative data are also discussed...
  2. pmc Identification of an atypical variant of logopenic progressive aphasia
    Mary M Machulda
    Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, United States Electronic address
    Brain Lang 127:139-44. 2013
    ..The mild atypical group also showed mild neuropsychological impairment. The subjects with mild aphasia and neuropsychological impairment despite long disease duration may represent a slowly progressive variant of lvPPA. ..
  3. pmc Functional magnetic resonance imaging changes in amnestic and nonamnestic mild cognitive impairment during encoding and recognition tasks
    Mary M Machulda
    Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Int Neuropsychol Soc 15:372-82. 2009
    ..The diminished parietal and frontal activation in naMCI may reflect compromised ability to perform nonmemory (i.e., attention/executive, visuospatial function) components of the task...
  4. pmc Effect of APOE ε4 status on intrinsic network connectivity in cognitively normal elderly subjects
    Mary M Machulda
    Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA
    Arch Neurol 68:1131-6. 2011
    ..To examine default mode and salience network functional connectivity as a function of APOE ε4 status in a group of cognitively normal age-, sex-, and education-matched older adults...
  5. pmc Elevated occipital β-amyloid deposition is associated with widespread cognitive impairment in logopenic progressive aphasia
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA
    J Neurol Neurosurg Psychiatry 84:1357-64. 2013
    ....
  6. pmc Practice effects and longitudinal cognitive change in normal aging vs. incident mild cognitive impairment and dementia in the Mayo Clinic Study of Aging
    Mary M Machulda
    a Department of Psychiatry and Psychology, College of Medicine, Mayo Clinic, Rochester, MN, USA
    Clin Neuropsychol 27:1247-64. 2013
    ..Modeling cognitive change in an epidemiologic sample may serve as a useful benchmark for evaluating cognitive change in future intervention studies. ..
  7. pmc Microbleeds in the logopenic variant of primary progressive aphasia
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, MN, USA Electronic address
    Alzheimers Dement 10:62-6. 2014
    ..We aimed to assess the presence and clinical correlates of microbleeds in lvPPA...
  8. pmc Distinct regional anatomic and functional correlates of neurodegenerative apraxia of speech and aphasia: an MRI and FDG-PET study
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
    Brain Lang 125:245-52. 2013
    ..Progressive agrammatic aphasia and AOS have non-overlapping regional correlations, suggesting that these are dissociable clinical features that have different neuroanatomical underpinnings...
  9. pmc Syndromes dominated by apraxia of speech show distinct characteristics from agrammatic PPA
    Keith A Josephs
    Department of Neurology Behavioral Neurology, Mayo Clinic, Rochester, MN, USA
    Neurology 81:337-45. 2013
    ..We assessed whether clinical and imaging features of subjects with apraxia of speech (AOS) more severe than aphasia (dominant AOS) are more similar to agrammatic primary progressive aphasia (agPPA) or to primary progressive AOS (PPAOS)...
  10. pmc Head trauma and in vivo measures of amyloid and neurodegeneration in a population-based study
    Michelle M Mielke
    From the Divisions of Epidemiology M M Mielke, R O R, R C P, Y E G and Biomedical Statistics and Informatics H J W, S D W, Department of Health Sciences Research Departments of Neurology R S, D S K, R O R, R C P, Psychiatry and Psychology M M Machulda, and Radiology P V, V J L, C R J, Mayo Clinic, Rochester, MN and Departments of Psychiatry, Psychology, and Neurology Y E G, Mayo Clinic, Scottsdale, AZ
    Neurology 82:70-6. 2014
    ..We determined whether head trauma was associated with amyloid deposition and neurodegeneration among individuals who were cognitively normal (CN) or had mild cognitive impairment (MCI)...
  11. doi request reprint Working memory and language network dysfunctions in logopenic aphasia: a task-free fMRI comparison with Alzheimer's dementia
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, MN, USA Electronic address
    Neurobiol Aging 36:1245-52. 2015
    ..Patterns of network dysfunction differ across these 2 clinical variants of Alzheimer's disease, with lvPPA particularly associated with disruptions in the language and left working memory networks. ..
  12. pmc FDG PET and MRI in logopenic primary progressive aphasia versus dementia of the Alzheimer's type
    Ajay Madhavan
    Department of Radiology, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 8:e62471. 2013
    ....
  13. doi request reprint Microbleeds in atypical presentations of Alzheimer's disease: a comparison to dementia of the Alzheimer's type
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, MN, USA
    J Alzheimers Dis 45:1109-17. 2015
    ..However, little is known about the frequency or distribution of microbleeds in subjects with AD that present with atypical clinical presentations...
  14. doi request reprint Clinical and neuroimaging biomarkers of amyloid-negative logopenic primary progressive aphasia
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, MN, United States Electronic address
    Brain Lang 142:45-53. 2015
    ..There was very little evidence for clinical differences between the groups. Strikingly asymmetric neuroimaging findings with relatively preserved right hemisphere may provide clues that AD pathology is absent in lvPPA. ..
  15. pmc MRI and MRS predictors of mild cognitive impairment in a population-based sample
    Kejal Kantarci
    Department of Radiology, Mayo Clinic, Rochester, MN, USA
    Neurology 81:126-33. 2013
    ..To investigate MRI and proton magnetic resonance spectroscopy (MRS) predictors of mild cognitive impairment (MCI) in cognitively normal older adults...
  16. pmc Independent comparison of CogState computerized testing and a standard cognitive battery with neuroimaging
    Michelle M Mielke
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA Department of Neurology, Mayo Clinic, Rochester, MN, USA Electronic address
    Alzheimers Dement 10:779-89. 2014
    ..Inexpensive, non-invasive tools for assessing Alzheimer-type pathophysiologies are needed. Computerized cognitive assessments are prime candidates...
  17. doi request reprint Vascular and amyloid pathologies are independent predictors of cognitive decline in normal elderly
    Prashanthi Vemuri
    1 Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN, USA
    Brain 138:761-71. 2015
    ....
  18. pmc APOE ε4 influences β-amyloid deposition in primary progressive aphasia and speech apraxia
    Keith A Josephs
    Division of Behavioral Neurology, Department of Neurology, Mayo Clinic, Rochester, MN, USA Division of Movement Disorders, Department of Neurology, Mayo Clinic, Rochester, MN, USA Electronic address
    Alzheimers Dement 10:630-6. 2014
    ..Apolipoprotein E ε4 (APOE ε4) is a risk factor for β-amyloid deposition in Alzheimer's disease dementia. Its influence on β-amyloid deposition in speech and language disorders, including primary progressive aphasia (PPA), is unclear...
  19. doi request reprint White matter integrity determined with diffusion tensor imaging in older adults without dementia: influence of amyloid load and neurodegeneration
    Kejal Kantarci
    Department of Radiology, Mayo Clinic, Rochester, Minnesota
    JAMA Neurol 71:1547-54. 2014
    ....
  20. pmc Quantitative application of the primary progressive aphasia consensus criteria
    Meredith R Wicklund
    From the Division of Behavioral Neurology M R W, K A J, Speech Pathology, Department of Neurology J R D, E A S, Division of Neurocognitive Disorders, Department of Psychiatry and Psychology M M M, and Division of Radiology Research, Department of Radiology J L W, Mayo Clinic, Rochester, MN
    Neurology 82:1119-26. 2014
    ..To determine how well the consensus criteria could classify subjects with primary progressive aphasia (PPA) using a quantitative speech and language battery that matches the test descriptions provided by the consensus criteria...
  21. pmc Occupational differences between Alzheimer's and aphasic dementias: implication for teachers
    Keith A Josephs
    Department of Neurology Behavioral Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Am J Alzheimers Dis Other Demen 28:612-6. 2013
    ..We identified an association between progressive SLDs and the occupation of teaching. Since teaching is a communication demanding occupation, teachers may be more sensitive to the development of speech and language impairments. ..
  22. pmc Progranulin-associated PiB-negative logopenic primary progressive aphasia
    Keith A Josephs
    Department of Neurology Division of Behavioral Neurology, Mayo Clinic, Rochester, MN, USA
    J Neurol 261:604-14. 2014
    ..Identification of such patients, however, should prompt testing for GRN mutations, since GRN-positive patients do not have distinctive features, yet account for 50 % of this patient population...
  23. pmc The evolution of primary progressive apraxia of speech
    Keith A Josephs
    1 Department of Neurology Behavioural Neurology, Mayo Clinic, Rochester, MN 55905, USA 2 Department of Neurology Movement Disorders, Mayo Clinic, Rochester, MN 55905, USA
    Brain 137:2783-95. 2014
    ..These findings help improve our understanding of primary progressive apraxia of speech and provide some important prognostic guidelines...
  24. pmc Nonverbal oral apraxia in primary progressive aphasia and apraxia of speech
    Hugo Botha
    From the Departments of Neurology H B, J R D, E A S, K A J, Psychology and Psychiatry M M M, and Radiology J L W, Mayo Clinic, Rochester, MN
    Neurology 82:1729-35. 2014
    ....
  25. pmc Aphasia with left occipitotemporal hypometabolism: a novel presentation of posterior cortical atrophy?
    Meredith R Wicklund
    Division of Behavioral Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Clin Neurosci 20:1237-40. 2013
    ..Posterior cortical atrophy may present focally with left occipitotemporal metabolism characterized clinically with a progressive fluent aphasia and prominent ventral visuospatial deficits with loss of insight. ..
  26. pmc Characterizing a neurodegenerative syndrome: primary progressive apraxia of speech
    Keith A Josephs
    Behavioural Neurology and Movement Disorders, Mayo Clinic, 200 1st Street S W, Rochester, MN 55905, USA
    Brain 135:1522-36. 2012
    ..A syndrome characterized by progressive pure apraxia of speech clearly exists, with a neuroanatomic correlate of superior lateral premotor and supplementary motor atrophy, making this syndrome distinct from primary progressive aphasia...
  27. pmc Non-stationarity in the "resting brain's" modular architecture
    David T Jones
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 7:e39731. 2012
    ..DMN dwell time in specific modular configurations may also underlie the TF-fMRI findings that have been described in mild cognitive impairment and cognitively normal subjects who are at risk for Alzheimer's dementia...
  28. doi request reprint Neuropsychiatric symptoms in primary progressive aphasia and apraxia of speech
    Tarun D Singh
    Department of Neurology, Mayo Clinic, Rochester, Minn, USA
    Dement Geriatr Cogn Disord 39:228-38. 2015
    ....
  29. pmc Assessing the temporal relationship between cognition and gait: slow gait predicts cognitive decline in the Mayo Clinic Study of Aging
    Michelle M Mielke
    Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, 200 First Street S W, Rochester, MN 55905, USA
    J Gerontol A Biol Sci Med Sci 68:929-37. 2013
    ..The association between gait speed and cognition has been reported; however, there is limited knowledge about the temporal associations between gait slowing and cognitive decline among cognitively normal individuals...
  30. ncbi request reprint Alzheimer's disease patients' cognitive status and course years prior to symptom recognition
    Jane H Cerhan
    Mayo Clinic College of Medicine Rochester, Minnesota, USA
    Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 14:227-35. 2007
    ..A significant interaction (but no group effect) was seen for verbal comprehension...
  31. doi request reprint Neuropsychiatric symptoms, APOE ε4, and the risk of incident dementia: a population-based study
    Anna Pink
    From Mayo Clinic Translational Neuroscience and Aging Program A P, J K R, J I A, Y E G, and Departments of Psychiatry and Psychology Y E G and Neurology Y E G, Mayo Clinic, Scottsdale, AZ Departments of Neurology M M B, D S K, R C P and Psychiatry and Psychology M M Machulda, Divisions of Epidemiology R O R, M M Mielke, R C P, Y E G and Biomedical Statistics and Informatics T J C, V S P, Department of Health Sciences Research, Mayo Clinic, Rochester, MN International Clinical Research Center A P, G B S, O S, J K R, Y E G, Brno, Czech Republic and Paracelsus Medical University A P, Salzburg, Austria
    Neurology 84:935-43. 2015
    ..To investigate the population-based interaction between a biological variable (APOE ε4), neuropsychiatric symptoms, and the risk of incident dementia among subjects with prevalent mild cognitive impairment (MCI)...
  32. doi request reprint Resolution of neuropsychological and FDG-PET abnormalities in a patient with neuropsychiatric systemic lupus erythematosus
    Anahita Adeli
    Departments of Neurology Psychiatry and Psychology, Mayo Clinic, Rochester, MN
    Cogn Behav Neurol 26:161-6. 2013
    ..F-18 fluorodeoxyglucose positron emission tomography shows promise in the diagnosis and treatment monitoring of patients who have lupus with neuropsychiatric involvement. ..
  33. ncbi request reprint Altered functional MR imaging language activation in elderly individuals with cerebral leukoaraiosis
    Kirk M Welker
    Department of Radiology, Division of Neuroradiology, Mayo Clinic, 200 First St SW, Charlton 2 X ray, Rochester, MN 55902, USA
    Radiology 265:222-32. 2012
    ..To test the hypothesis that leukoaraiosis alters functional activation during a semantic decision language task...
  34. pmc Characterization of frontotemporal dementia and/or amyotrophic lateral sclerosis associated with the GGGGCC repeat expansion in C9ORF72
    Bradley F Boeve
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Brain 135:765-83. 2012
    ..While variability exists, most cases with this mutation have a characteristic spectrum of demographic, clinical, neuropsychological, neuroimaging and especially neuropathological findings...
  35. pmc Late-onset Alzheimer's risk variants in memory decline, incident mild cognitive impairment, and Alzheimer's disease
    Minerva M Carrasquillo
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA
    Neurobiol Aging 36:60-7. 2015
    ..Discovery of biologically functional variants at these loci may uncover stronger effects on memory and incident disease. ..
  36. ncbi request reprint A plateau in pre-Alzheimer memory decline: evidence for compensatory mechanisms?
    G E Smith
    Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 69:133-9. 2007
    ..To compare logistic and bilogistic models to describe the pattern of cognitive decline in the preclinical phase of Alzheimer disease (AD)...
  37. pmc Comparison of memory fMRI response among normal, MCI, and Alzheimer's patients
    M M Machulda
    Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 61:500-6. 2003
    ..To determine whether an fMRI memory encoding task distinguishes among cognitively normal elderly individuals, patients with mild cognitive impairment (MCI), and patients with early Alzheimer's disease (AD)...
  38. pmc Functional inferences vary with the method of analysis in fMRI
    M M Machulda
    Department of Radiology, Magnetic Resonance Research, Mayo Clinic, Rochester, Minnesota 55905, USA
    Neuroimage 14:1122-7. 2001
    ..Using data processing methods that are independent of the arbitrary selection of cutoff values for thresholding activation maps may reduce the likelihood of obtaining spurious results...