Research Topics
Genomes and GenesSpecies | Joseph LustgartenSummaryAffiliation: Mayo Clinic Country: USA Publications
Research Grants
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Detail Information
Publications
Cancer, aging and immunotherapy: lessons learned from animal modelsJoseph Lustgarten
Department of Immunology, Mayo Clinic Arizona, Mayo Clinic College of Medicine, Scottsdale, AZ 85259, USA
Cancer Immunol Immunother 58:1979-89. 2009....
Foxp3-positive macrophages display immunosuppressive properties and promote tumor growthSoraya Zorro Manrique
Department of Immunology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA
J Exp Med 208:1485-99. 2011..For the first time, these studies demonstrate the existence of a distinct subpopulation of naturally occurring macrophage regulatory cells in which expression of Foxp3 correlates with suppressive function...- Blockade of CCL1 inhibits T regulatory cell suppressive function enhancing tumor immunity without affecting T effector responsesDominique B Hoelzinger
Department of Immunology, Mayo Clinic College of Medicine, Scottsdale, AZ 85259, USA
J Immunol 184:6833-42. 2010..These studies demonstrate that neutralization of CCL1 can be used as an adjuvant to antitumor immunotherapy, as a means of reversing the immunosuppressive function of Tregs without compromising T cell effector function... - Comparative kinetic analyses of gene profiles of naïve CD4+ and CD8+ T cells from young and old animals reveal novel age-related alterationsNoweeda Mirza
Department of Immunology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA
Aging Cell 10:853-67. 2011..Evaluation of these differences provides in-depth insight into potential functional and phenotypical differences among these populations... - Signals through 4-1BB inhibit T regulatory cells by blocking IL-9 production enhancing antitumor responsesShannon E Smith
Department of Immunology, Cancer Center Scottsdale, Mayo Clinic Arizona, Mayo Clinic College of Medicine, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA
Cancer Immunol Immunother 60:1775-87. 2011.... - B7-H1 expression on old CD8+ T cells negatively regulates the activation of immune responses in aged animalsNoweeda Mirza
Department of Immunology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA
J Immunol 184:5466-74. 2010..These studies demonstrated that expression of B7-H1 in old CD8(+) T cells impairs the proper activation of these cells and that blockade of B7-H1 could be critical to optimally stimulate a CD8 T cell response in the old... - Targeting the tumor microenvironment with anti-neu/anti-CD40 conjugated nanoparticles for the induction of antitumor immune responsesAna Lucia Dominguez
Mayo Clinic College of Medicine, Department of Immunology, Mayo Clinic Arizona, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA
Vaccine 28:1383-90. 2010..These results indicate that anti-neu/anti-CD40-NP with immunomodulatory properties are safe and can be used effectively as cancer vaccines strategy for the specific induction of antitumor immune responses... - Systemic targeting of CpG-ODN to the tumor microenvironment with anti-neu-CpG hybrid molecule and T regulatory cell depletion induces memory responses in BALB-neuT tolerant miceSanjay Sharma
Mayo Clinic College of Medicine, Department of Immunology, Mayo Clinic Arizona, Scottsdale, Arizona 85259, USA
Cancer Res 68:7530-40. 2008..Taken together, these results indicate that CpG-ODN-targeted therapy and depletion of T-regs optimally activate a primary response and generate a protective memory response against self-tumor antigens... - Malignant melanoma in the 21st century: the emerging molecular landscapeAleksandar Sekulic
Department of Dermatology, Mayo Clinic, Scottsdale, AZ 85259, USA
Mayo Clin Proc 83:825-46. 2008..We review the emerging molecular landscape of melanoma and its implications for better management of patients with melanoma... - Implications of aging and self-tolerance on the generation of immune and antitumor immune responsesAna Lucia Dominguez
Department of Immunology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona 85259, USA
Cancer Res 68:5423-31. 2008.... 
CpG-ODN but not other TLR-ligands restore the antitumor responses in old mice: the implications for vaccinations in the agedSanjay Sharma
Cancer Center Scottsdale, Mayo Clinic Arizona, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA
Cancer Immunol Immunother 57:549-61. 2008..We evaluated whether targeting APCs following injection with Poly I:C, LPS, flagellin, imiquimod and CpG-ODN would induce an antitumor response in the old...
Research Grants
- Mechanism of Action of CpG-ODN in Generating Tumor Immunity in the AgedJoseph Lustgarten; Fiscal Year: 2010..Overall, the information gained from these studies will reveal strategies for controlling and manipulating the immune system to develop more effective immunotherapies in young and old tolerant hosts. ..
- Optimization of Tumor Vaccines for the AgedJoseph Lustgarten; Fiscal Year: 2011..The information of these studies will reveal new strategies for controlling and manipulating the immune system to develop more effective cancer-immunotherapies in old tolerant hosts. ..
- Mechanism of Action of CpG-ODN in Generating Tumor Immunity in the AgedJoseph Lustgarten; Fiscal Year: 2009..Overall, the information gained from these studies will reveal strategies for controlling and manipulating the immune system to develop more effective immunotherapies in young and old tolerant hosts. ..
- Optimization of Tumor Vaccines for the AgedJoseph Lustgarten; Fiscal Year: 2006..The information gained from these studies could have important clinical implications for the development of vaccination strategies in the elderly. ..
- ANTIBODY MEDIATED T CELL RECOGNITION FOR CANCER THERAPYJoseph Lustgarten; Fiscal Year: 2003....