Joseph Lustgarten

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Foxp3-positive macrophages display immunosuppressive properties and promote tumor growth
    Soraya Zorro Manrique
    Department of Immunology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA
    J Exp Med 208:1485-99. 2011
  2. doi request reprint Cancer, aging and immunotherapy: lessons learned from animal models
    Joseph Lustgarten
    Department of Immunology, Mayo Clinic Arizona, Mayo Clinic College of Medicine, Scottsdale, AZ 85259, USA
    Cancer Immunol Immunother 58:1979-89. 2009
  3. doi request reprint Blockade of CCL1 inhibits T regulatory cell suppressive function enhancing tumor immunity without affecting T effector responses
    Dominique B Hoelzinger
    Department of Immunology, Mayo Clinic College of Medicine, Scottsdale, AZ 85259, USA
    J Immunol 184:6833-42. 2010
  4. doi request reprint B7-H1 expression on old CD8+ T cells negatively regulates the activation of immune responses in aged animals
    Noweeda Mirza
    Department of Immunology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA
    J Immunol 184:5466-74. 2010
  5. pmc Systemic targeting of CpG-ODN to the tumor microenvironment with anti-neu-CpG hybrid molecule and T regulatory cell depletion induces memory responses in BALB-neuT tolerant mice
    Sanjay Sharma
    Mayo Clinic College of Medicine, Department of Immunology, Mayo Clinic Arizona, Scottsdale, Arizona 85259, USA
    Cancer Res 68:7530-40. 2008
  6. doi request reprint Comparative kinetic analyses of gene profiles of naïve CD4+ and CD8+ T cells from young and old animals reveal novel age-related alterations
    Noweeda Mirza
    Department of Immunology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA
    Aging Cell 10:853-67. 2011
  7. doi request reprint Signals through 4-1BB inhibit T regulatory cells by blocking IL-9 production enhancing antitumor responses
    Shannon E Smith
    Department of Immunology, Cancer Center Scottsdale, Mayo Clinic Arizona, Mayo Clinic College of Medicine, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA
    Cancer Immunol Immunother 60:1775-87. 2011
  8. pmc Targeting the tumor microenvironment with anti-neu/anti-CD40 conjugated nanoparticles for the induction of antitumor immune responses
    Ana Lucia Dominguez
    Mayo Clinic College of Medicine, Department of Immunology, Mayo Clinic Arizona, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA
    Vaccine 28:1383-90. 2010
  9. doi request reprint Implications of aging and self-tolerance on the generation of immune and antitumor immune responses
    Ana Lucia Dominguez
    Department of Immunology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona 85259, USA
    Cancer Res 68:5423-31. 2008
  10. ncbi request reprint CpG-ODN but not other TLR-ligands restore the antitumor responses in old mice: the implications for vaccinations in the aged
    Sanjay Sharma
    Cancer Center Scottsdale, Mayo Clinic Arizona, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA
    Cancer Immunol Immunother 57:549-61. 2008

Research Grants

Collaborators

Detail Information

Publications11

  1. pmc Foxp3-positive macrophages display immunosuppressive properties and promote tumor growth
    Soraya Zorro Manrique
    Department of Immunology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA
    J Exp Med 208:1485-99. 2011
    ..For the first time, these studies demonstrate the existence of a distinct subpopulation of naturally occurring macrophage regulatory cells in which expression of Foxp3 correlates with suppressive function...
  2. doi request reprint Cancer, aging and immunotherapy: lessons learned from animal models
    Joseph Lustgarten
    Department of Immunology, Mayo Clinic Arizona, Mayo Clinic College of Medicine, Scottsdale, AZ 85259, USA
    Cancer Immunol Immunother 58:1979-89. 2009
    ....
  3. doi request reprint Blockade of CCL1 inhibits T regulatory cell suppressive function enhancing tumor immunity without affecting T effector responses
    Dominique B Hoelzinger
    Department of Immunology, Mayo Clinic College of Medicine, Scottsdale, AZ 85259, USA
    J Immunol 184:6833-42. 2010
    ..These studies demonstrate that neutralization of CCL1 can be used as an adjuvant to antitumor immunotherapy, as a means of reversing the immunosuppressive function of Tregs without compromising T cell effector function...
  4. doi request reprint B7-H1 expression on old CD8+ T cells negatively regulates the activation of immune responses in aged animals
    Noweeda Mirza
    Department of Immunology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA
    J Immunol 184:5466-74. 2010
    ..These studies demonstrated that expression of B7-H1 in old CD8(+) T cells impairs the proper activation of these cells and that blockade of B7-H1 could be critical to optimally stimulate a CD8 T cell response in the old...
  5. pmc Systemic targeting of CpG-ODN to the tumor microenvironment with anti-neu-CpG hybrid molecule and T regulatory cell depletion induces memory responses in BALB-neuT tolerant mice
    Sanjay Sharma
    Mayo Clinic College of Medicine, Department of Immunology, Mayo Clinic Arizona, Scottsdale, Arizona 85259, USA
    Cancer Res 68:7530-40. 2008
    ..Taken together, these results indicate that CpG-ODN-targeted therapy and depletion of T-regs optimally activate a primary response and generate a protective memory response against self-tumor antigens...
  6. doi request reprint Comparative kinetic analyses of gene profiles of naïve CD4+ and CD8+ T cells from young and old animals reveal novel age-related alterations
    Noweeda Mirza
    Department of Immunology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA
    Aging Cell 10:853-67. 2011
    ..Evaluation of these differences provides in-depth insight into potential functional and phenotypical differences among these populations...
  7. doi request reprint Signals through 4-1BB inhibit T regulatory cells by blocking IL-9 production enhancing antitumor responses
    Shannon E Smith
    Department of Immunology, Cancer Center Scottsdale, Mayo Clinic Arizona, Mayo Clinic College of Medicine, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA
    Cancer Immunol Immunother 60:1775-87. 2011
    ....
  8. pmc Targeting the tumor microenvironment with anti-neu/anti-CD40 conjugated nanoparticles for the induction of antitumor immune responses
    Ana Lucia Dominguez
    Mayo Clinic College of Medicine, Department of Immunology, Mayo Clinic Arizona, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA
    Vaccine 28:1383-90. 2010
    ..These results indicate that anti-neu/anti-CD40-NP with immunomodulatory properties are safe and can be used effectively as cancer vaccines strategy for the specific induction of antitumor immune responses...
  9. doi request reprint Implications of aging and self-tolerance on the generation of immune and antitumor immune responses
    Ana Lucia Dominguez
    Department of Immunology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona 85259, USA
    Cancer Res 68:5423-31. 2008
    ....
  10. ncbi request reprint CpG-ODN but not other TLR-ligands restore the antitumor responses in old mice: the implications for vaccinations in the aged
    Sanjay Sharma
    Cancer Center Scottsdale, Mayo Clinic Arizona, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA
    Cancer Immunol Immunother 57:549-61. 2008
    ..We evaluated whether targeting APCs following injection with Poly I:C, LPS, flagellin, imiquimod and CpG-ODN would induce an antitumor response in the old...
  11. pmc Malignant melanoma in the 21st century: the emerging molecular landscape
    Aleksandar Sekulic
    Department of Dermatology, Mayo Clinic, Scottsdale, AZ 85259, USA
    Mayo Clin Proc 83:825-46. 2008
    ..We review the emerging molecular landscape of melanoma and its implications for better management of patients with melanoma...

Research Grants11

  1. Mechanism of Action of CpG-ODN in Generating Tumor Immunity in the Aged
    Joseph Lustgarten; Fiscal Year: 2010
    ..Overall, the information gained from these studies will reveal strategies for controlling and manipulating the immune system to develop more effective immunotherapies in young and old tolerant hosts. ..
  2. Optimization of Tumor Vaccines for the Aged
    Joseph Lustgarten; Fiscal Year: 2011
    ..The information of these studies will reveal new strategies for controlling and manipulating the immune system to develop more effective cancer-immunotherapies in old tolerant hosts. ..
  3. Optimization of Tumor Vaccines for the Aged
    Joseph Lustgarten; Fiscal Year: 2006
    ..The information gained from these studies could have important clinical implications for the development of vaccination strategies in the elderly. ..
  4. ANTIBODY MEDIATED T CELL RECOGNITION FOR CANCER THERAPY
    Joseph Lustgarten; Fiscal Year: 2003
    ....
  5. Mechanism of Action of CpG-ODN in Generating Tumor Immunity in the Aged
    Joseph Lustgarten; Fiscal Year: 2009
    ..Overall, the information gained from these studies will reveal strategies for controlling and manipulating the immune system to develop more effective immunotherapies in young and old tolerant hosts. ..