Affiliation: Mayo Clinic
Liu X, Yaszemski M, Lu L. Expansile crosslinked polymersomes for pH sensitive delivery of doxorubicin. Biomater Sci. 2016;4:245-9 pubmed publisher
..Its unique stability under physiological conditions and large swelling capability under low pH conditions give this polymersome promising potential for anticancer drug delivery. ..
Olthof M, Kempen D, Liu X, Dadsetan M, Tryfonidou M, Yaszemski M, et al
. Effect of biomaterial electrical charge on in vivo bone formation. Tissue Eng Part A. 2019;: pubmed publisher
..Overall, this study clearly shows that negative charge enhances bone formation compared to neutral and positive charge in OPF composites. ..
Zhou Z, Liu X, Wu W, Park S, Miller Ii A, Terzic A, et al
. Effective nerve cell modulation by electrical stimulation of carbon nanotube embedded conductive polymeric scaffolds. Biomater Sci. 2018;6:2375-2385 pubmed publisher
..Overall, this study provides a new promising strategy for using electrically conductive PCLF-CNT nerve scaffolds in regenerative medicine. ..
Olthof M, Lu L, Tryfonidou M, Loozen L, Pouran B, Yaszemski M, et al
. The osteoinductive effect of controlled BMP-2 release is location-dependent. Tissue Eng Part A. 2018;: pubmed publisher
..Additionally, more bone formation in OPF-BP compared to ACS at both application sites emphasizes the role of biomaterials as a scaffold to achieve proper bone tissue formation. ..
Oppenheimer Velez M, Giambini H, Rezaei A, Camp J, Khosla S, Lu L. The trabecular effect: A population-based longitudinal study on age and sex differences in bone mineral density and vertebral load bearing capacity. Clin Biomech (Bristol, Avon). 2018;55:73-78 pubmed publisher
..This might lead to a higher incidence of fragility fractures in osteoporotic women. Our non-invasive, quantitative computed tomography image-based approach may improve prevention, monitoring, and management of fractures. ..
Lu L, Arbit H, Herrick J, Segovis S, Maran A, Yaszemski M. Tissue engineered constructs: perspectives on clinical translation. Ann Biomed Eng. 2015;43:796-804 pubmed publisher
..A case study on nerve cuffs is presented to illustrate the regulatory process. Finally, perspectives on commercialization such as finding a company partner and funding issues, as well as physician culture change, are presented. ..
Wu S, Liu X, Miller A, Cheng Y, Yeh M, Lu L. Strengthening injectable thermo-sensitive NIPAAm-g-chitosan hydrogels using chemical cross-linking of disulfide bonds as scaffolds for tissue engineering. Carbohydr Polym. 2018;192:308-316 pubmed publisher
..We suggested that the thiol-modified thermo-sensitive polysaccharide hydrogels are promising to be a cell-laden biomaterial for tissue regeneration. ..
Olthof M, Tryfonidou M, Dadsetan M, Dhert W, Yaszemski M, Kempen D, et al
. In Vitro and In Vivo Correlation of BMP-2 Release Profiles from Complex Delivery Vehicles. Tissue Eng Part C Methods. 2018;: pubmed publisher
..Altogether, these results imply that more sophisticated in vitro systems should be used in bone regeneration to accurately discriminate and predict in vivo BMP-2 release from different complex delivery vehicles. ..
Liu X, Gong P, Song P, Xie F, Miller Ii A, Chen S, et al
. Fast functionalization of ultrasound microbubbles using strain promoted click chemistry. Biomater Sci. 2018;6:623-632 pubmed publisher
..This fast ligation shortens the microbubble reaction time and preserves essential amounts of microbubbles for further in situ imaging and delivery of therapeutics. ..