Phillip Low

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. doi request reprint Efficacy and safety of rifampicin for multiple system atrophy: a randomised, double-blind, placebo-controlled trial
    Phillip A Low
    Mayo Clinic, Rochester, MN, USA Electronic address
    Lancet Neurol 13:268-75. 2014
  2. pmc Autonomic dysfunction in chronic inflammatory demyelinating polyradiculoneuropathy
    J J Figueroa
    Department of Neurology, Mayo Clinic, Rochester, MN, USA
    Neurology 78:702-8. 2012
  3. pmc Autopsy confirmed multiple system atrophy cases: Mayo experience and role of autonomic function tests
    Valeria Iodice
    Neurovascular and Autonomic Medicine Unit, Imperial College London, UK
    J Neurol Neurosurg Psychiatry 83:453-9. 2012
  4. ncbi request reprint Laboratory evaluation of autonomic function
    Phillip A Low
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Suppl Clin Neurophysiol 57:358-68. 2004
  5. ncbi request reprint Autonomic symptoms and diabetic neuropathy: a population-based study
    Phillip A Low
    Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Diabetes Care 27:2942-7. 2004
  6. ncbi request reprint Zonisamide and associated oligohidrosis and hyperthermia
    Phillip A Low
    Department of Neurology, Mayo Clinic College of Medicine, 811 Guggenheim Building, Rochester, MN 55905, USA
    Epilepsy Res 62:27-34. 2004
  7. doi request reprint Prevalence of orthostatic hypotension
    Phillip A Low
    Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Clin Auton Res 18:8-13. 2008
  8. pmc Management of neurogenic orthostatic hypotension: an update
    Phillip A Low
    Department of Neurology, Mayo Clinic Rochester, MN 55905, USA
    Lancet Neurol 7:451-8. 2008
  9. ncbi request reprint Evaluation of sudomotor function
    Phillip A Low
    Department of Neurology, Mayo Foundation, 811 Guggenheim, 200 First Street SW, Rochester, MN 55905, USA
    Clin Neurophysiol 115:1506-13. 2004
  10. ncbi request reprint Autonomic neuropathies
    Phillip A Low
    Department of Neurology, Mayo Medical School, Mayo Clinic, Rochester, Minnesota 55905, USA
    Curr Opin Neurol 15:605-9. 2002

Research Grants

  1. DIABETIC AUTONOMIC NEUROPATHY
    Phillip Low; Fiscal Year: 2001
  2. Peripheral Nerve Ischemia
    Phillip Low; Fiscal Year: 2004
  3. NERVE BLOOD FLOW IN NORMAL AND ISCHEMIC PERIPHERAL NERVE
    Phillip Low; Fiscal Year: 1993
  4. NERVE BLOOD FLOW IN NORMAL AND ISCHEMIC PERIPHERAL NERVE
    Phillip Low; Fiscal Year: 1999
  5. Autonomic Disorders Programs Project
    Phillip Low; Fiscal Year: 2007

Detail Information

Publications81

  1. doi request reprint Efficacy and safety of rifampicin for multiple system atrophy: a randomised, double-blind, placebo-controlled trial
    Phillip A Low
    Mayo Clinic, Rochester, MN, USA Electronic address
    Lancet Neurol 13:268-75. 2014
    ..We aimed to assess the safety and efficacy of rifampicin in patients with multiple system atrophy...
  2. pmc Autonomic dysfunction in chronic inflammatory demyelinating polyradiculoneuropathy
    J J Figueroa
    Department of Neurology, Mayo Clinic, Rochester, MN, USA
    Neurology 78:702-8. 2012
    ..The Composite Autonomic Severity Score (CASS) is a validated instrument for laboratory quantitation of autonomic failure derived from standard autonomic reflex tests. We characterized dysautonomia in CIDP using CASS...
  3. pmc Autopsy confirmed multiple system atrophy cases: Mayo experience and role of autonomic function tests
    Valeria Iodice
    Neurovascular and Autonomic Medicine Unit, Imperial College London, UK
    J Neurol Neurosurg Psychiatry 83:453-9. 2012
    ..Published autopsy confirmed cases have provided reasonable neurological characterisation but have lacked adequate autonomic function testing...
  4. ncbi request reprint Laboratory evaluation of autonomic function
    Phillip A Low
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Suppl Clin Neurophysiol 57:358-68. 2004
  5. ncbi request reprint Autonomic symptoms and diabetic neuropathy: a population-based study
    Phillip A Low
    Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Diabetes Care 27:2942-7. 2004
    ....
  6. ncbi request reprint Zonisamide and associated oligohidrosis and hyperthermia
    Phillip A Low
    Department of Neurology, Mayo Clinic College of Medicine, 811 Guggenheim Building, Rochester, MN 55905, USA
    Epilepsy Res 62:27-34. 2004
    ..In each case, oligohidrosis was reversible upon discontinuation of zonisamide. Ensuring that children remain cool and well hydrated during hot weather can minimize the potential for hyperthermia resulting from oligohidrosis...
  7. doi request reprint Prevalence of orthostatic hypotension
    Phillip A Low
    Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Clin Auton Res 18:8-13. 2008
    ..The development of OH in normal subjects is associated with an increased mortality rate. OH in diabetes is also associated with a significant increase in mortality rate...
  8. pmc Management of neurogenic orthostatic hypotension: an update
    Phillip A Low
    Department of Neurology, Mayo Clinic Rochester, MN 55905, USA
    Lancet Neurol 7:451-8. 2008
    ....
  9. ncbi request reprint Evaluation of sudomotor function
    Phillip A Low
    Department of Neurology, Mayo Foundation, 811 Guggenheim, 200 First Street SW, Rochester, MN 55905, USA
    Clin Neurophysiol 115:1506-13. 2004
  10. ncbi request reprint Autonomic neuropathies
    Phillip A Low
    Department of Neurology, Mayo Medical School, Mayo Clinic, Rochester, Minnesota 55905, USA
    Curr Opin Neurol 15:605-9. 2002
    ..To update recent advances in the pathogenesis, pathophysiology and treatment of some autonomic neuropathies...
  11. pmc Sudomotor dysfunction in autoimmune autonomic ganglionopathy
    K Kimpinski
    Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Neurology 73:1501-6. 2009
    ..Many patients with this disorder have difficulties with thermoregulation and anhidrosis. Our objective was to characterize the distribution and severity of sudomotor dysfunction in this disorder...
  12. pmc Patterns of neuropathy and autonomic failure in patients with amyloidosis
    Annabel K Wang
    Department of Neurology, University of California, Irvine, USA
    Mayo Clin Proc 83:1226-30. 2008
    ..To define the clinical patterns of peripheral neuropathy and autonomic testing abnormalities in patients with amyloidosis...
  13. pmc Prospective differentiation of multiple system atrophy from Parkinson disease, with and without autonomic failure
    Axel Lipp
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Arch Neurol 66:742-50. 2009
    ....
  14. ncbi request reprint Pyridostigmine treatment trial in neurogenic orthostatic hypotension
    Wolfgang Singer
    Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Arch Neurol 63:513-8. 2006
    ..By enhancing ganglionic transmission, pyridostigmine bromide can potentially ameliorate OH without worsening supine hypertension...
  15. ncbi request reprint Nitrergic contribution to gastric relaxation induced by glucagon-like peptide-1 (GLP-1) in healthy adults
    Christopher N Andrews
    Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Clinic, 200 First St S W, Rochester, MN 55905, USA
    Am J Physiol Gastrointest Liver Physiol 292:G1359-65. 2007
    ..01 vs. GLP-1 alone). These data are consistent with the hypothesis that nitric oxide partly mediates the effects of GLP-1 on postprandial but not fasting gastric volumes in humans...
  16. ncbi request reprint Acetylcholinesterase inhibition in patients with orthostatic intolerance
    Wolfgang Singer
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Neurophysiol 23:476-81. 2006
    ..Our findings support the suggested mechanisms of enhanced sympathetic ganglionic neurotransmission and a vagal shift in cardiac sympathovagal balance. Acetylcholinesterase inhibition could be a new useful concept in the treatment of OI...
  17. ncbi request reprint The spectrum of autoimmune autonomic neuropathies
    Caroline M Klein
    Department of Neurology, Medical University of South Carolina, Charleston, SC, USA
    Ann Neurol 53:752-8. 2003
    ....
  18. pmc Association of N-type calcium channel autoimmunity in patients with autoimmune autonomic ganglionopathy
    Kurt Kimpinski
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Auton Neurosci 150:136-9. 2009
    ..Autonomic testing revealed severe impairment of sudomotor, cardiovagal, and adrenergic domains. These findings raise the possibility that other autoantibodies may contribute to the pathogenesis of AAG...
  19. ncbi request reprint Evidence of an intrinsic sinus node abnormality in patients with postural tachycardia syndrome
    Wolfgang Singer
    Department of Neurology, Mayo Clinic, Rochester, Minn 55905, USA
    Mayo Clin Proc 77:246-52. 2002
    ....
  20. pmc Systemic postganglionic adrenergic studies do not distinguish Parkinson's disease from multiple system atrophy
    Axel Lipp
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    J Neurol Sci 281:15-9. 2009
    ..We examined if pharmacological dissection of the adrenergic neuron can distinguish between MSA and PD...
  21. ncbi request reprint Adrenergic and vagal baroreflex sensitivity in autonomic failure
    Christine Schrezenmaier
    Department of Neurology, Mayo Foundation, Rochester, MN 55905, USA
    Arch Neurol 64:381-6. 2007
    ..Baroreflex sensitivity is widely used to quantify the vagal component of the reflex, but the adrenergic component is not quantifiable in the autonomic laboratory...
  22. ncbi request reprint Blood pressure recovery from Valsalva maneuver in patients with autonomic failure
    Elizabeth R Vogel
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 65:1533-7. 2005
    ..Blood pressure (BP) changes in response to the Valsalva maneuver (VM) reflect the integrity of the baroreflex that regulates BP, and the phases of VM are widely used indices of adrenergic evaluation...
  23. ncbi request reprint Detection of small-fiber neuropathy by sudomotor testing
    Victoria A Low
    Department of Neurology, Mayo Clinic, Guggenheim 811, 200 First Street SW, Rochester, Minnesota 55905, USA
    Muscle Nerve 34:57-61. 2006
    ..Sudomotor examination is thus a highly sensitive detection tool in DSFN. Autonomic involvement is mainly distal, and additionally may involve adrenergic and the long cardiovagal fibers...
  24. ncbi request reprint Depressive symptoms and life satisfaction in patients with multiple system atrophy
    Lisa M Benrud-Larson
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55095, USA
    Mov Disord 20:951-7. 2005
    ..Adequate treatment of comorbid depression may improve quality of life in this population, despite the presence of other debilitating deficits...
  25. pmc Ventilatory and cardiovascular responses to hypercapnia and hypoxia in multiple-system atrophy
    Axel Lipp
    Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Arch Neurol 67:211-6. 2010
    ..The cardiovascular responses to chemoreflex activation in MSA have not been explored to date...
  26. pmc Signs and symptoms versus nerve conduction studies to diagnose diabetic sensorimotor polyneuropathy: Cl vs. NPhys trial
    Peter J Dyck
    Peripheral Neuropathy Research Laboratory, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    Muscle Nerve 42:157-64. 2010
    ..Study physician dx from signs and symptoms were excessively variable, often overestimating DSPN. Specific approaches to improving clinical proficiency should be tested...
  27. doi request reprint Syncope while driving: clinical characteristics, causes, and prognosis
    Dan Sorajja
    Division of Cardiovascular Diseases, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Circulation 120:928-34. 2009
    ..The risk of syncope occurring while driving has obvious implications for personal and public safety. We aimed to define the clinical characteristics, causes, and prognosis of syncope while driving...
  28. pmc Effects of glucagon-like peptide-1, yohimbine, and nitrergic modulation on sympathetic and parasympathetic activity in humans
    Adil E Bharucha
    Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Clinic, 200 First St S W, Rochester, MN 55905, USA
    Am J Physiol Regul Integr Comp Physiol 295:R874-80. 2008
    ..GLP-1 increases skeletal muscle sympathetic nerve activity but does not appear to affect cardiac sympathetic or parasympathetic activity in humans...
  29. pmc Other autonomic neuropathies associated with ganglionic antibody
    Paola Sandroni
    Mayo Clinic, Department of Neurology, 200 First Street SW, Rochester, MN 55905, USA
    Auton Neurosci 146:13-7. 2009
    ..Other antigens and antibodies yet to be identified are more likely to be responsible in these disorders...
  30. ncbi request reprint Involvement of hypocretin neurons in multiple system atrophy
    Eduardo E Benarroch
    Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Acta Neuropathol 113:75-80. 2007
    ..This is the first demonstration of loss of Hcrt/Orx neurons in MSA, which is consistent with a system degeneration of neurons involved in homeostatic function, including sleep and autonomic regulation, in this disorder...
  31. ncbi request reprint Depletion of putative chemosensitive respiratory neurons in the ventral medullary surface in multiple system atrophy
    Eduardo E Benarroch
    Department of Neurology, Rochester, MN, USA
    Brain 130:469-75. 2007
    ..This may provide a possible morphological basis for impaired respiratory chemosensitivity and central sleep apnoea in this disorder...
  32. pmc Pilot study of pyridostigmine in constipated patients with autonomic neuropathy
    Adil E Bharucha
    Clinical and Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Clinic, 200 First St S W, Rochester, MN 55905, USA
    Clin Auton Res 18:194-202. 2008
    ..Our aims were to evaluate the efficacy of cholinesterase inhibitors for dysautonomia and chronic constipation and to assess whether acute effects could predict the long term response...
  33. pmc Antibody-mediated impairment and homeostatic plasticity of autonomic ganglionic synaptic transmission
    Zhengbei Wang
    Department of Neurology, UT Southwestern Medical Center, Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9036, USA
    Exp Neurol 222:114-9. 2010
    ..Homeostatic plasticity in autonomic neurotransmission could help explain the spontaneous clinical recovery seen in some AAG patients and may also play an important role in regulating normal autonomic reflexes...
  34. pmc Invited Article: Autonomic ganglia: target and novel therapeutic tool
    Steven Vernino
    Department of Neurology, UT Southwestern Medical Center, Dallas, TX, USA
    Neurology 70:1926-32. 2008
    ..Recent evidence also suggests a potential role for acetylcholinesterase inhibitors in the treatment of postural tachycardia syndrome...
  35. ncbi request reprint Effect of age on adrenergic and vagal baroreflex sensitivity in normal subjects
    Chih Cheng Huang
    Mayo Clinic, Department of Neurology, 200 First Street SW, Rochester, Minnesota 55905, USA
    Muscle Nerve 36:637-42. 2007
    ..The adrenergic parameters correlated well with each other but not significantly with BRS-v. The results indicate that both BRS-a and BRS-v become blunted with increasing age and that these indices behave independently of each other...
  36. pmc Decreased peripheral nerve damage after ischemia-reperfusion injury in mice lacking TNF-alpha
    Yanping Wang
    Department of Neurology, Mayo Clinic, Rochester, MN, USA
    J Neurol Sci 267:107-11. 2008
    ..We conclude that TNF-alpha plays an essential role in the pathogenesis of peripheral nerve ischemia-reperfusion injury, possibly partly through the activation of NF-kappaB...
  37. pmc Differential involvement of the periaqueductal gray in multiple system atrophy
    Eduardo E Benarroch
    Department of Neurology, Mayo Clinic, Rochester, MN, United States
    Auton Neurosci 158:111-7. 2010
    ..There was accumulation of glial cytoplasmic inclusions in all PAG columns in MSA. Our findings indicate involvement of the PAG columns in MSA, which may contribute to autonomic disturbances in this disorder...
  38. pmc Loss of A5 noradrenergic neurons in multiple system atrophy
    Eduardo E Benarroch
    Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Acta Neuropathol 115:629-34. 2008
    ..The severity of cell loss was comparable to that of locus ceruleus neurons in these cases. Our results indicate that A5 neurons are severely affected in MSA and this may contribute to some of the manifestations of this synucleinopathy...
  39. ncbi request reprint Differential involvement of hypothalamic vasopressin neurons in multiple system atrophy
    Eduardo E Benarroch
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Brain 129:2688-96. 2006
    ..Loss of AVP neurons in the SCN may contribute to impaired circadian regulation of endocrine and autonomic functions...
  40. ncbi request reprint Involvement of medullary regions controlling sympathetic output in Lewy body disease
    Eduardo E Benarroch
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Brain 128:338-44. 2005
    ..In LBD, orthostatic hypotension may be due primarily to involvement of sympathetic ganglion neurons rather than ventrolateral medulla neurons...
  41. ncbi request reprint Orthostatic headaches without CSF leak in postural tachycardia syndrome
    Bahram Mokri
    Department of Neurology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Neurology 61:980-2. 2003
    ..Orthostatic headaches are not always caused by CSF leak or supine intracranial hypotension. Occasionally they may be the major clinical manifestation of postural tachycardia syndrome or orthostatic intolerance...
  42. ncbi request reprint Erythromelalgia: vasculopathy, neuropathy, or both? A prospective study of vascular and neurophysiologic studies in erythromelalgia
    Mark D P Davis
    Department of Dermatology, Mayo Clinic, Rochester, MN 55905, USA
    Arch Dermatol 139:1337-43. 2003
    ..To assess the frequency and type of vascular changes and neurologic abnormalities in patients with erythromelalgia...
  43. ncbi request reprint Ischemia-reperfusion injury of peripheral nerve in experimental diabetic neuropathy
    Yanping Wang
    Department of Neurology, Mayo Clinic, 811 Guggenheim, 200 First Street SW, Rochester, MN 55905, USA
    J Neurol Sci 227:101-7. 2004
    ..Reperfusion exaggerated morphological pathology in 1-month STZ-induced diabetic peripheral nerve...
  44. ncbi request reprint Correlates of functional disability in patients with postural tachycardia syndrome: preliminary cross-sectional findings
    Lisa M Benrud-Larson
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Health Psychol 22:643-8. 2003
    ..Results suggest that modifiable psychological factors play a role in the functional limitations experienced by patients with POTS. Longitudinal research is necessary to confirm these relationships...
  45. ncbi request reprint Myeloneuropathy and anemia due to copper malabsorption
    Neeraj Kumar
    Department of Neurology, E8A Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    J Neurol 251:747-9. 2004
    ..The limited literature on neurological manifestations of acquired copper deficiency suggests that the clinical presentation resembles the myeloneuropathy seen with vitamin B12 deficiency...
  46. pmc Passive transfer of autoimmune autonomic neuropathy to mice
    Steven Vernino
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Neurosci 24:7037-42. 2004
    ..The antibody effect is potentially reversible, justifying early use of immunomodulatory therapy directed at lowering IgG levels and abrogating IgG production in patients with AAN...
  47. ncbi request reprint Involvement of medullary serotonergic groups in multiple system atrophy
    Eduardo E Benarroch
    Department of Neurology, Mayo Clinic, 811 Guggenheim Building, 200 First Street SW, Rochester, MN 55905, USA
    Ann Neurol 55:418-22. 2004
    ..Depletion of serotonergic neurons may contribute to impaired control of sympathetic outflow and other abnormalities in MSA...
  48. ncbi request reprint Testing the autonomic nervous system
    Phillip A Low
    Department of Neurology, Mayo Foundation, Rochester, Minnesota 55905, USA
    Semin Neurol 23:407-21. 2003
    ....
  49. ncbi request reprint Depletion of ventromedullary NK-1 receptor-immunoreactive neurons in multiple system atrophy
    Eduardo E Benarroch
    Department of Neurology, Mayo Foundation, Rochester, MN 55904, USA
    Brain 126:2183-90. 2003
    ....
  50. ncbi request reprint Experimental autoimmune autonomic neuropathy
    Steven Vernino
    Department of Neurology, Mayo Graduate and Medical Schools, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Neurophysiol 90:2053-9. 2003
    ..These findings define the autonomic physiology and histopathology of this novel animal model and support the concept that AAN in humans is a disorder of ganglionic cholinergic synaptic transmission caused by ganglionic nAChR antibodies...
  51. ncbi request reprint Acute hemodynamic effects of abdominal exercise with and without breath holding
    Jonathan T Finnoff
    Sports Medicien Center, Mayo Clinic, Rochester, MN 55905, USA
    Arch Phys Med Rehabil 84:1017-22. 2003
    ....
  52. ncbi request reprint Quality of life in patients with postural tachycardia syndrome
    Lisa M Benrud-Larson
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 77:531-7. 2002
    ..To quantify quality of life and identify demographic and clinical correlates of functioning in a well-characterized sample of patients with postural tachycardia syndrome (POTS)...
  53. ncbi request reprint Heart rate-dependent electrocardiogram abnormalities in patients with postural tachycardia syndrome
    Wolfgang Singer
    Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Auton Neurosci 103:106-13. 2003
    ..These findings may reflect intrinsic cardiac electrophysiologic abnormalities or may be secondary due to abnormalities of cardiac autonomic innervation...
  54. ncbi request reprint Complex regional pain syndrome type I: incidence and prevalence in Olmsted county, a population-based study
    Paola Sandroni
    Mayo Clinic, Rochester, MN 55905, USA
    Pain 103:199-207. 2003
    ..These results suggest that invasive treatment of CRPS may not be warranted in the majority of cases...
  55. ncbi request reprint Spectral analysis of slow modulation of EEG amplitude and cardiovascular variables in subjects with postural tachycardia syndrome
    Terrence D Lagerlund
    Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States
    Auton Neurosci 117:132-42. 2005
    ....
  56. ncbi request reprint Effects of linearly polarized 0.6-1.6 microM irradiation on stellate ganglion function in normal subjects and people with complex regional pain (CRPS I)
    Jeffrey R Basford
    Department of Physical Medicine and Rehabilitation, Autonomic Disorder Center, Mayo Clinic and Foundation, 200 Southwest Second Street, Rochester, Minnesota 55905, USA
    Lasers Surg Med 32:417-23. 2003
    ..This study was designed to assess the physiological effects of this latter approach and to quantitate its benefits in people with upper extremity pain due to Complex Regional Pain Syndrome I (CRPS I, RSD)...
  57. ncbi request reprint What is the minimum duration of head-up tilt necessary to detect orthostatic hypotension?
    Jade A Gehrking
    Dept of Neurology, Mayo Clinic, Rochester MN 55905, USA
    Clin Auton Res 15:71-5. 2005
    ..The purpose of the current study was 1) to determine the minimum duration of HUT necessary to detect OH and 2) to identify different patterns of orthostatic blood pressure (BP) response in patients with OH...
  58. ncbi request reprint Pyridostigmine for treatment of neurogenic orthostatic hypotension [correction of hypertension]--a follow-up survey study
    Paola Sandroni
    Autonomic Disorders Center, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Clin Auton Res 15:51-3. 2005
    ..Aim of the study was to evaluate self-reported efficacy and patients' satisfaction with the medication. Most patients were very satisfied with the medication and chose to continue it...
  59. ncbi request reprint Autonomic dysfunction in peripheral nerve disease
    Phillip A Low
    Department of Neurology, Mayo Foundation, 811 Guggenheim, 200 First Street SW, Rochester, Minnesota 55905, USA
    Muscle Nerve 27:646-61. 2003
    ..Non-invasive autonomic testing complements clinical and electrophysiological characterization of the autonomic neuropathies...
  60. ncbi request reprint A randomized, controlled exploratory study of clonidine in diarrhea-predominant irritable bowel syndrome
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Gastroenterology Research Unit, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Clin Gastroenterol Hepatol 1:111-21. 2003
    ....
  61. pmc The effects of hypertonic dextrose injection on connective tissue and nerve conduction through the rabbit carpal tunnel
    Yuichi Yoshii
    Biomechanics Laboratory, Division of Orthopedic Research, Mayo Clinic, Rochester, MN 55905, USA
    Arch Phys Med Rehabil 90:333-9. 2009
    ..We hypothesized that dextrose injection would induce proliferation of the SSCT, hinder median nerve conduction, and alter SSCT mechanical properties, similar to what is observed in patients with carpal tunnel syndrome (CTS)...
  62. pmc Quantitative sensation and autonomic test abnormalities in transthyretin amyloidosis polyneuropathy
    Dong Hwee Kim
    Peripheral Neuropathy Research Laboratory, Mayo Clinic, Rochester, Minnesota, USA
    Muscle Nerve 40:363-70. 2009
    ..This study provides a rationale for the use of QAT, QST, and Sigma5 NC nds as standard, objective, and quantitative measures for assessing the severity of TTR-A-PN in epidemiologic surveys, therapeutic trials, and medical practice...
  63. pmc Effect of position on valsalva maneuver: supine versus 20 degree position
    Elizabeth R Vogel
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
    J Clin Neurophysiol 25:313-6. 2008
    ..We recommend this modification for laboratory evaluation of the VM, whenever a flat-top response is seen...
  64. doi request reprint Immunotherapy for autoimmune autonomic ganglionopathy
    Valeria Iodice
    Mayo Clinic, Department of Neurology, 200 First Street SW, Rochester, MN 55905, USA
    Auton Neurosci 146:22-5. 2009
    ..This review summarizes current treatment options including IVIG, PE, and immunosuppressants agents, alone or in combination...
  65. ncbi request reprint Excessive heart rate response to orthostatic stress in postural tachycardia syndrome is not caused by anxiety
    Shizue Masuki
    Dept of Anesthesiology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    J Appl Physiol 102:896-903. 2007
    ..1). These results suggest that the HR response to orthostatic stress in POTS patients is not caused by anxiety but that it is a physiological response that maintains arterial pressure during venous pooling...
  66. ncbi request reprint Postural orthostatic tachycardia syndrome: the Mayo clinic experience
    Mark J Thieben
    Autonomic Disorders Center, Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Mayo Clin Proc 82:308-13. 2007
    ..To evaluate the prevalence and pathogenetic mechanisms of postural orthostatic tachycardia syndrome (POTS)...
  67. pmc Preventing and treating orthostatic hypotension: As easy as A, B, C
    Juan J Figueroa
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Cleve Clin J Med 77:298-306. 2010
    ..We provide easy-to-remember management recommendations, using a combination of drug and nondrug treatments that have proven efficacious...
  68. ncbi request reprint Association between angiotensin-converting enzyme gene polymorphisms and QT duration in a multiethnic population in Hawaii
    Andrew Grandinetti
    University of Hawaii at Manoa, John A Burns School of Medicine, Department of Public Health and Epidemiology, Honolulu, Hawaii 96822, USA
    Auton Neurosci 130:51-6. 2006
    ..We report findings of a study of the relationship between QTc, increased QTc (> 440 ms) and angiotensin-converting enzyme (ACE) genotype in a multiethnic, population-based study completed in rural Hawaii...
  69. ncbi request reprint Inappropriate sinus tachycardia, postural orthostatic tachycardia syndrome, and overlapping syndromes
    Peter A Brady
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic College of Medicine and Mayo Foundation, Rochester, Minnesota 55905, USA
    Pacing Clin Electrophysiol 28:1112-21. 2005
    ..Pathogenesis of these overlapping syndromes is poorly understood. Diagnostic and therapeutic approaches have not been standardized...
  70. ncbi request reprint A screen of candidate genes and influence of beta2-adrenergic receptor genotypes in postural tachycardia syndrome
    Kim K Nickander
    Department of Neurology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, Minnesota 55905, USA
    Auton Neurosci 120:97-103. 2005
    ....
  71. ncbi request reprint Postural orthostatic tachycardia syndrome: anesthetic implications in the obstetric patient
    Matthew D McEvoy
    Department of Anesthesiology and Perioperative Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Anesth Analg 104:166-7. 2007
    ..We discuss anesthetic concerns with this disease in the parturient and suggest approaches for management of this disease...
  72. ncbi request reprint Reduced stroke volume during exercise in postural tachycardia syndrome
    Shizue Masuki
    Department of Anesthesiology, Mayo Clinic Foundation, Rochester, MN 55905, USA
    J Appl Physiol 103:1128-35. 2007
    ..60), and 75 W (R(2) = 0.32) (P < 0.01). These results suggest that greater elevation in HR in POTS patients during exercise, especially while upright, was secondary to reduced SV and associated with exercise intolerance...
  73. ncbi request reprint Arterial baroreflex control of heart rate during exercise in postural tachycardia syndrome
    Shizue Masuki
    Department of Anesthesiology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    J Appl Physiol 103:1136-42. 2007
    ..These results suggest that the tachycardia during exercise in POTS was not due to abnormal baroreflex control of HR...
  74. ncbi request reprint Impaired glucose tolerance is associated with postganglionic sudomotor impairment
    Andrew Grandinetti
    Clin Auton Res 17:231-3. 2007
    ..Responses were significantly impaired in those with IGT, which may be indicative of early distal small fiber neuropathy...
  75. ncbi request reprint Potential outcome measures and trial design issues for multiple system atrophy
    Susanne May
    Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, California 92093 0717, USA
    Mov Disord 22:2371-7. 2007
    ..The UMSARS Motor Examination score exhibited the most favorable characteristics as an outcome measure for a therapeutic trial in MSA with 1 year of follow-up...
  76. ncbi request reprint Pacing does not improve hypotension in patients with severe orthostatic hypotension--a prospective randomized cross-over pilot study
    Zakir H Sahul
    Dept of Internal Medicine, Mayo Clinic and Foundation, Rochester MN, USA
    Clin Auton Res 14:255-8. 2004
    ..To date, however, no randomized controlled studies have been performed to validate the approach...
  77. ncbi request reprint Use of lower abdominal compression to combat orthostatic hypotension in patients with autonomic dysfunction
    Adrianus A J Smit
    Dept of Internal Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Clin Auton Res 14:167-75. 2004
    ..05). We conclude that in patients with neurogenic orthostatic hypotension, abdominal compression increases standing blood pressure to a varying degree by increasing stroke volume...
  78. ncbi request reprint Idiopathic autonomic neuropathy: comparison of cases seropositive and seronegative for ganglionic acetylcholine receptor antibody
    Paola Sandroni
    Department of Neurology, Mayo Foundation, Guggenheim 811, 200 First Street SW, Rochester, MN 55905, USA
    Arch Neurol 61:44-8. 2004
    ....
  79. pmc Characterization of ganglionic acetylcholine receptor autoantibodies
    Steven Vernino
    Department of Neurology, UT Southwestern Medical Center, Dallas Texas 75390 9036, United States
    J Neuroimmunol 197:63-9. 2008
    ..Muscle and ganglionic AChR antibody specificities are distinct. Antibody crossreactivity between AChRs with different alpha subunits is uncommon but can occur...
  80. ncbi request reprint Morphometry of dorsal root ganglion in chronic experimental diabetic neuropathy
    Motoko Kishi
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Diabetes 51:819-24. 2002
    ....
  81. ncbi request reprint Vasovagal syncope in patients with reduced left ventricular function
    Christopher M Stanton
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Clin Auton Res 17:33-8. 2007
    ..Although this study had a small cohort size, the predominantly vasodepressor response without a cardioinhibitory component warrants further investigation into mechanisms of VVS in these patients...

Research Grants27

  1. DIABETIC AUTONOMIC NEUROPATHY
    Phillip Low; Fiscal Year: 2001
    ..abstract_text> ..
  2. Peripheral Nerve Ischemia
    Phillip Low; Fiscal Year: 2004
    ..We will then define the therapeutic windows and evaluate the mechanisms of production of hypothermic and antioxidant neuroprotection (Specific aim number 2) from reperfusion injury. ..
  3. NERVE BLOOD FLOW IN NORMAL AND ISCHEMIC PERIPHERAL NERVE
    Phillip Low; Fiscal Year: 1993
    ..Finally, nerve catecholamines, eicosanoids, MDA and SOD will be measured in sural nerve biopsied for reasons unrelated to this proposal to apply some of these techniques and strategies to humans...
  4. NERVE BLOOD FLOW IN NORMAL AND ISCHEMIC PERIPHERAL NERVE
    Phillip Low; Fiscal Year: 1999
    ..The fifth aim is to continue our studies of nerve vasoregulation. We will study vasopressin, neuropeptide Y, and cilostazol (vasodilator and phosphodiesterase inhibitor on nerve blood flow. ..
  5. Autonomic Disorders Programs Project
    Phillip Low; Fiscal Year: 2007
    ..PROJECT 1 P.I.: Phillip Low, MD Title: Autonomic Disorders Program Project Description (provided by applicant): In this competitive renewal,..