P A Low

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. ncbi request reprint Autonomic dysfunction in peripheral nerve disease
    Phillip A Low
    Department of Neurology, Mayo Foundation, 811 Guggenheim, 200 First Street SW, Rochester, Minnesota 55905, USA
    Muscle Nerve 27:646-61. 2003
  2. ncbi request reprint Efficacy of midodrine vs placebo in neurogenic orthostatic hypotension. A randomized, double-blind multicenter study. Midodrine Study Group
    P A Low
    Department of Neurology, Mayo Clinic, Rochester, Minn 55905, USA
    JAMA 277:1046-51. 1997
  3. ncbi request reprint Sensitivity to vasovagal maneuvers in normal children and adults
    R W Arnold
    Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905
    Mayo Clin Proc 66:797-804. 1991
  4. ncbi request reprint Consensus statement on the diagnosis of multiple system atrophy
    S Gilman
    Department of Neurology, University of Michigan Medical Center, Ann Arbor 48109 0316, USA
    J Auton Nerv Syst 74:189-92. 1998
  5. pmc Dopamine cell loss in the periaqueductal gray in multiple system atrophy and Lewy body dementia
    E E Benarroch
    Mayo Clinic, Department of Neurology, 811 Guggenheim Bldg, 200 First Street SW, Rochester, MN 55905, USA
    Neurology 73:106-12. 2009
  6. pmc Sudomotor dysfunction in autoimmune autonomic ganglionopathy
    K Kimpinski
    Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Neurology 73:1501-6. 2009
  7. ncbi request reprint The effect of aging on cardiac autonomic and postganglionic sudomotor function
    P A Low
    Department of Neurology, Mayo Foundation, Rochester 55905
    Muscle Nerve 13:152-7. 1990
  8. ncbi request reprint Autoantibodies to ganglionic acetylcholine receptors in autoimmune autonomic neuropathies
    S Vernino
    Department of Neurology, Mayo Clinic, Rochester, Minn 55905, USA
    N Engl J Med 343:847-55. 2000
  9. pmc Autonomic dysfunction in chronic inflammatory demyelinating polyradiculoneuropathy
    J J Figueroa
    Department of Neurology, Mayo Clinic, Rochester, MN, USA
    Neurology 78:702-8. 2012
  10. ncbi request reprint Sensitivity to orthostatic stress and beta-receptor activation in patients with isoproterenol-induced vasovagal syncope: a case controlled study
    W K Shen
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Pacing Clin Electrophysiol 22:615-25. 1999

Collaborators

Detail Information

Publications101 found, 100 shown here

  1. ncbi request reprint Autonomic dysfunction in peripheral nerve disease
    Phillip A Low
    Department of Neurology, Mayo Foundation, 811 Guggenheim, 200 First Street SW, Rochester, Minnesota 55905, USA
    Muscle Nerve 27:646-61. 2003
    ..Non-invasive autonomic testing complements clinical and electrophysiological characterization of the autonomic neuropathies...
  2. ncbi request reprint Efficacy of midodrine vs placebo in neurogenic orthostatic hypotension. A randomized, double-blind multicenter study. Midodrine Study Group
    P A Low
    Department of Neurology, Mayo Clinic, Rochester, Minn 55905, USA
    JAMA 277:1046-51. 1997
    ..Midodrine hydrochloride, an alpha-agonist, could improve orthostatic BP by increasing vasomotor and venomotor tone...
  3. ncbi request reprint Sensitivity to vasovagal maneuvers in normal children and adults
    R W Arnold
    Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905
    Mayo Clin Proc 66:797-804. 1991
    ..Changes in finger blood flow did not correlate with changes in heart rate for any maneuver. This study provides a response profile of relative sensitivities to strong vasovagal maneuvers in normal children and adults...
  4. ncbi request reprint Consensus statement on the diagnosis of multiple system atrophy
    S Gilman
    Department of Neurology, University of Michigan Medical Center, Ann Arbor 48109 0316, USA
    J Auton Nerv Syst 74:189-92. 1998
    ..The diagnosis of probable MSA requires the criterion for autonomic failure/urinary dysfunction plus poorly levodopa responsive parkinsonism or cerebellar ataxia. The diagnosis of definite MSA requires pathological confirmation...
  5. pmc Dopamine cell loss in the periaqueductal gray in multiple system atrophy and Lewy body dementia
    E E Benarroch
    Mayo Clinic, Department of Neurology, 811 Guggenheim Bldg, 200 First Street SW, Rochester, MN 55905, USA
    Neurology 73:106-12. 2009
    ..Excessive daytime sleepiness (EDS) is a common manifestation of multiple system atrophy (MSA) and dementia with Lewy bodies (DLB) but involvement of these neurons has not yet been explored...
  6. pmc Sudomotor dysfunction in autoimmune autonomic ganglionopathy
    K Kimpinski
    Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Neurology 73:1501-6. 2009
    ..Many patients with this disorder have difficulties with thermoregulation and anhidrosis. Our objective was to characterize the distribution and severity of sudomotor dysfunction in this disorder...
  7. ncbi request reprint The effect of aging on cardiac autonomic and postganglionic sudomotor function
    P A Low
    Department of Neurology, Mayo Foundation, Rochester 55905
    Muscle Nerve 13:152-7. 1990
    ..Cardiac vagal function is impaired with age, but postganglionic sympathetic function is little affected by age, suggesting selectivity of effects of aging on autonomic function...
  8. ncbi request reprint Autoantibodies to ganglionic acetylcholine receptors in autoimmune autonomic neuropathies
    S Vernino
    Department of Neurology, Mayo Clinic, Rochester, Minn 55905, USA
    N Engl J Med 343:847-55. 2000
    ..Autoantibodies specific for nicotinic acetylcholine receptors in the autonomic ganglia are potentially pathogenic and may serve as serologic markers of various forms of autoimmune autonomic neuropathy...
  9. pmc Autonomic dysfunction in chronic inflammatory demyelinating polyradiculoneuropathy
    J J Figueroa
    Department of Neurology, Mayo Clinic, Rochester, MN, USA
    Neurology 78:702-8. 2012
    ..The Composite Autonomic Severity Score (CASS) is a validated instrument for laboratory quantitation of autonomic failure derived from standard autonomic reflex tests. We characterized dysautonomia in CIDP using CASS...
  10. ncbi request reprint Sensitivity to orthostatic stress and beta-receptor activation in patients with isoproterenol-induced vasovagal syncope: a case controlled study
    W K Shen
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Pacing Clin Electrophysiol 22:615-25. 1999
    ..These observations hold the key to early detection of hemodynamic changes and potential therapeutic interventions before patients become symptomatic...
  11. ncbi request reprint Rostral raphe involvement in Lewy body dementia and multiple system atrophy
    E E Benarroch
    Department of Neurology, Mayo Clinic, 811 Guggenheim Building, 200 First Street SW, Rochester, MN 55905, USA
    Acta Neuropathol 114:213-20. 2007
    ..Although loss of rostral raphe neurons may contribute to depression in DLB, this appears to be less likely in MSA. Factors other than the neurochemical phenotype determine neuronal vulnerability in MSA...
  12. doi request reprint Mesopontine cholinergic neuron involvement in Lewy body dementia and multiple system atrophy
    A M Schmeichel
    Mayo Clinic, Department of Neurology, 811 Guggenheim Building, 200 First Street SW, Rochester, MN 55905, USA
    Neurology 70:368-73. 2008
    ..We sought to determine the degree of PPT/LDT involvement in DLB compared to MSA...
  13. ncbi request reprint Consensus statement on the diagnosis of multiple system atrophy
    S Gilman
    Department of Neurology, University of Michigan Medical Center, Ann Arbor 48109 0316, USA
    J Neurol Sci 163:94-8. 1999
    ..The diagnosis of probable MSA requires the criterion for autonomic failure/urinary dysfunction plus poorly levodopa responsive parkinsonism or cerebellar ataxia. The diagnosis of definite MSA requires pathological confirmation...
  14. ncbi request reprint The acetylcholine-induced flare response in evaluation of small fiber dysfunction
    E E Benarroch
    Department of Neurology, Mayo Clinic, Rochester, MN 55905
    Ann Neurol 29:590-5. 1991
    ..abstract truncated at 250 words)..
  15. ncbi request reprint Influence of posture on the Valsalva manoeuvre
    W Singer
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Clin Sci (Lond) 100:433-40. 2001
    ..Sympathetic activation in the upright position seems to blunt baroreflexes, leading to similar HR responses in spite of larger changes in BP...
  16. ncbi request reprint Involvement of vagal autonomic nuclei in multiple system atrophy and Lewy body disease
    E E Benarroch
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 66:378-83. 2006
    ..The relationship between DMV and NAmb involvement and the gastrointestinal or cardiovagal manifestations in MSA and LBD is unclear...
  17. pmc Efficacy of immunotherapy in seropositive and seronegative putative autoimmune autonomic ganglionopathy
    V Iodice
    Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Neurology 72:2002-8. 2009
    ..To evaluate the efficacy of immunotherapy in the treatment of patients with seropositive and seronegative putative autoimmune autonomic ganglionopathy (AAG) using validated autonomic function tests and instruments...
  18. ncbi request reprint Baroreflex control of muscle sympathetic nerve activity in postural orthostatic tachycardia syndrome
    N Muenter Swift
    Department of Neurology Autonomic Disorders Center, Mayo Clinic, 200 First St SW, Charlton 7 271A, Rochester, MN 55905, USA
    Am J Physiol Heart Circ Physiol 289:H1226-33. 2005
    ..0001). Our results suggest that POTS patients have exaggerated MSNA responses to baroreflex challenges compared with healthy control subjects, although resting supine MSNA values did not differ between the groups...
  19. ncbi request reprint Lack of global vagal propensity in patients with oculocardiac reflex
    R W Arnold
    Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota
    Ophthalmology 101:1347-52. 1994
    ..Carotid sinus massage may help predict low heart rates during eye surgery...
  20. pmc Parabrachial nucleus involvement in multiple system atrophy
    E E Benarroch
    Department of Neurology, Mayo Clinic, Rochester, MN, USA Electronic address
    Auton Neurosci 177:170-4. 2013
    ..Neurons of the parabrachial nucleus (PBN) control respiratory rhythmogenesis and airway resistance...
  21. ncbi request reprint Splanchnic-mesenteric capacitance bed in the postural tachycardia syndrome (POTS)
    H Tani
    Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Auton Neurosci 86:107-13. 2000
    ..CONCLUSION: The main novel observations of increased resting SMA-BF, SMA-TAV supine, and reduced SMA-VR when compared with controls support the notion that there is excessive splanchnic capacity (pooling) at rest in POTS...
  22. pmc Second consensus statement on the diagnosis of multiple system atrophy
    S Gilman
    Department of Neurology, University of Michigan, 300 N Ingalls St, 3D15, Ann Arbor, MI 48109 5489, USA
    Neurology 71:670-6. 2008
    ..Since then, clinical, laboratory, neuropathologic, and imaging studies have advanced the field, requiring a fresh evaluation of diagnostic criteria. We held a second consensus conference in 2007 and present the results here...
  23. pmc Effects of glucagon-like peptide-1 and sympathetic stimulation on gastric accommodation in humans
    C N Andrews
    Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Clinic, Rochester, MN 55905, USA
    Neurogastroenterol Motil 19:716-23. 2007
    ..Yohimbine stimulates central sympathetic activity and in combination with GLP-1, augments postprandial accommodation in humans...
  24. ncbi request reprint Autonomic dysfunction in dementia with Lewy bodies
    P Thaisetthawatkul
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 62:1804-9. 2004
    ..To assess autonomic function in patients with dementia with Lewy bodies (DLB)...
  25. pmc Autoimmune autonomic ganglionopathy: IgG effects on ganglionic acetylcholine receptor current
    Z Wang
    Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9036, USA
    Neurology 68:1917-21. 2007
    ..Previous clinical studies and observations in animal models suggest that AAG is an antibody-mediated neurologic disorder...
  26. ncbi request reprint Levodopa and deprenyl treatment effects on peripheral indices of oxidant stress in Parkinson's disease
    J E Ahlskog
    Division of Movement Disorders, Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 46:796-801. 1996
    ..Thus, in contrast to in vitro studies, we did not detect evidence of oxidative damage in the circulation following levodopa administration, despite marked increase in the products of dopamine oxidative metabolism...
  27. ncbi request reprint Basal forebrain malformation with hyperhidrosis and hypothermia: variant of Shapiro's syndrome
    C J Klein
    Department of Neurology, Mayo Clinic, Rochester, MN, USA
    Neurology 56:254-6. 2001
    ..These findings expand the structural abnormalities and treatment options within the temperature dysregulating conditions of Shapiro's syndrome and "diencephalic epilepsy."..
  28. ncbi request reprint Renal concentration of alpha-tocopherol: dependence on gender and lack of effect on polycystic kidney disease in Han:SPRD rats
    V E Torres
    Department of Nephrology, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Am J Kidney Dis 31:687-93. 1998
    ..Although these results do not support the use of vitamin E in the treatment of polycystic kidney disease, observations in the Han:SPRD rat may or may not be relevant to human polycystic kidney disease...
  29. ncbi request reprint Effect of hyperbaric oxygenation on normal and chronic streptozotocin diabetic peripheral nerves
    P A Low
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905
    Exp Neurol 99:201-12. 1988
    ..The biochemical changes are suggestive of enhanced nerve energy metabolism induced by hyperbaric oxygenation. The altered albumin blood-nerve barrier index presumably results from the action of free radicals on endothelial cells...
  30. ncbi request reprint Time-frequency mapping of R-R interval during complex partial seizures of temporal lobe origin
    V Novak
    Department of Neurology, The Ohio State University, Columbus 43210, USA
    J Auton Nerv Syst 77:195-202. 1999
    ..Activation of autonomic nervous system is common with seizures. No reliable biological markers of impending seizures have been found. Evaluation of autonomic changes might help elucidate the transition from interictal to ictal states...
  31. ncbi request reprint IV immunoglobulin does not reverse established weakness in MS
    J H Noseworthy
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 55:1135-43. 2000
    ..Immunoglobulin (Ig) administration induces remyelination in the Theiler's virus model of MS...
  32. ncbi request reprint Calf venous compliance in multiple system atrophy
    A Lipp
    Autonomic Reflex Laboratory, Department of Neurology, Mayo Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Am J Physiol Heart Circ Physiol 293:H260-5. 2007
    ..We postulate that chronic venous distension that is associated with OH results in structural remodeling of veins, leading to reduced compliance, a change which may protect patients against orthostatic stress...
  33. ncbi request reprint Is sinus node modification appropriate for inappropriate sinus tachycardia with features of postural orthostatic tachycardia syndrome?
    W K Shen
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Pacing Clin Electrophysiol 24:217-30. 2001
    ..A primary subtle autonomic disregulation is frequently present in this population. Sinus node modification is not recommended in this patient population...
  34. ncbi request reprint Adynamic ileus in severe Guillain-Barré syndrome
    T M Burns
    Department of Neurology, Lahey Clinic, Burlington, Massachusetts, USA
    Muscle Nerve 24:963-5. 2001
    ..Medical management was successful in all patients. Patients with GBS infrequently develop ileus as a manifestation of dysautonomia...
  35. ncbi request reprint In vivo studies on receptor pharmacology of the human eccrine sweat gland
    P A Low
    Department of Neurology, Mayo Foundation, Rochester, MN 55905
    Clin Auton Res 2:29-34. 1992
    ..The inhibition of the nicotinic response may be secondary to M1 antagonism since pilocarpine is an M2 agonist and M1 antagonist and pirenzepine, a specific M1 antagonist, caused similar effects as pilocarpine...
  36. pmc Sudden cardiac death in diabetes mellitus: risk factors in the Rochester diabetic neuropathy study
    G A Suarez
    Neuropathy Research Laboratory, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    J Neurol Neurosurg Psychiatry 76:240-5. 2005
    ..To determine risk factors for sudden cardiac death and the role of diabetic autonomic neuropathy (DAN) in the Rochester diabetic neuropathy study (RDNS)...
  37. ncbi request reprint Prospective evaluation of somatic and autonomic small fibers in selected autonomic neuropathies
    W Singer
    Mayo Foundation, Rochester, MN, USA
    Neurology 62:612-8. 2004
    ..There are a number of distal and generalized small-fiber neuropathies. The neuropathologic basis is poorly understood as somatic and autonomic C fibers are not usually studied in the same region of the body...
  38. ncbi request reprint Distal symmetrical polyneuropathy: definition for clinical research
    J D England
    American Association of Electrodiagnostic Medicine, 421 First Avenue SW, Suite 300E, Rochester, MN 55902, USA
    Muscle Nerve 31:113-23. 2005
    ..The inclusion of this formalized case definition in clinical and epidemiological research studies will ensure greater consistency of case selection...
  39. pmc Acetylcholinesterase inhibition: a novel approach in the treatment of neurogenic orthostatic hypotension
    W Singer
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Neurol Neurosurg Psychiatry 74:1294-8. 2003
    ..Pharmacological treatment of orthostatic hypotension is often limited because of troublesome supine hypertension...
  40. ncbi request reprint Effects of glucagon-like peptide-1 and feeding on gastric volumes in diabetes mellitus with cardio-vagal dysfunction
    S Delgado-Aros
    Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Clinic, Rochester, MN 55905, USA
    Neurogastroenterol Motil 15:435-43. 2003
    ..Normal gastric volume response to feeding in diabetics with vagal neuropathy suggests that other mechanisms compensate for vagal denervation...
  41. ncbi request reprint Excessive heart rate response to orthostatic stress in postural tachycardia syndrome is not caused by anxiety
    Shizue Masuki
    Dept of Anesthesiology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    J Appl Physiol 102:896-903. 2007
    ..1). These results suggest that the HR response to orthostatic stress in POTS patients is not caused by anxiety but that it is a physiological response that maintains arterial pressure during venous pooling...
  42. ncbi request reprint Differential involvement of hypothalamic vasopressin neurons in multiple system atrophy
    Eduardo E Benarroch
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Brain 129:2688-96. 2006
    ..Loss of AVP neurons in the SCN may contribute to impaired circadian regulation of endocrine and autonomic functions...
  43. ncbi request reprint Detection of small-fiber neuropathy by sudomotor testing
    Victoria A Low
    Department of Neurology, Mayo Clinic, Guggenheim 811, 200 First Street SW, Rochester, Minnesota 55905, USA
    Muscle Nerve 34:57-61. 2006
    ..Sudomotor examination is thus a highly sensitive detection tool in DSFN. Autonomic involvement is mainly distal, and additionally may involve adrenergic and the long cardiovagal fibers...
  44. ncbi request reprint Association between angiotensin-converting enzyme gene polymorphisms and QT duration in a multiethnic population in Hawaii
    Andrew Grandinetti
    University of Hawaii at Manoa, John A Burns School of Medicine, Department of Public Health and Epidemiology, Honolulu, Hawaii 96822, USA
    Auton Neurosci 130:51-6. 2006
    ..We report findings of a study of the relationship between QTc, increased QTc (> 440 ms) and angiotensin-converting enzyme (ACE) genotype in a multiethnic, population-based study completed in rural Hawaii...
  45. ncbi request reprint Nitrergic contribution to gastric relaxation induced by glucagon-like peptide-1 (GLP-1) in healthy adults
    Christopher N Andrews
    Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Clinic, 200 First St S W, Rochester, MN 55905, USA
    Am J Physiol Gastrointest Liver Physiol 292:G1359-65. 2007
    ..01 vs. GLP-1 alone). These data are consistent with the hypothesis that nitric oxide partly mediates the effects of GLP-1 on postprandial but not fasting gastric volumes in humans...
  46. ncbi request reprint Acetylcholinesterase inhibition in patients with orthostatic intolerance
    Wolfgang Singer
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Neurophysiol 23:476-81. 2006
    ..Our findings support the suggested mechanisms of enhanced sympathetic ganglionic neurotransmission and a vagal shift in cardiac sympathovagal balance. Acetylcholinesterase inhibition could be a new useful concept in the treatment of OI...
  47. ncbi request reprint Depletion of putative chemosensitive respiratory neurons in the ventral medullary surface in multiple system atrophy
    Eduardo E Benarroch
    Department of Neurology, Rochester, MN, USA
    Brain 130:469-75. 2007
    ..This may provide a possible morphological basis for impaired respiratory chemosensitivity and central sleep apnoea in this disorder...
  48. ncbi request reprint Involvement of hypocretin neurons in multiple system atrophy
    Eduardo E Benarroch
    Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Acta Neuropathol 113:75-80. 2007
    ..This is the first demonstration of loss of Hcrt/Orx neurons in MSA, which is consistent with a system degeneration of neurons involved in homeostatic function, including sleep and autonomic regulation, in this disorder...
  49. ncbi request reprint Postural orthostatic tachycardia syndrome: the Mayo clinic experience
    Mark J Thieben
    Autonomic Disorders Center, Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Mayo Clin Proc 82:308-13. 2007
    ..To evaluate the prevalence and pathogenetic mechanisms of postural orthostatic tachycardia syndrome (POTS)...
  50. ncbi request reprint Adrenergic and vagal baroreflex sensitivity in autonomic failure
    Christine Schrezenmaier
    Department of Neurology, Mayo Foundation, Rochester, MN 55905, USA
    Arch Neurol 64:381-6. 2007
    ..Baroreflex sensitivity is widely used to quantify the vagal component of the reflex, but the adrenergic component is not quantifiable in the autonomic laboratory...
  51. pmc Pilot study of pyridostigmine in constipated patients with autonomic neuropathy
    Adil E Bharucha
    Clinical and Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Clinic, 200 First St S W, Rochester, MN 55905, USA
    Clin Auton Res 18:194-202. 2008
    ..Our aims were to evaluate the efficacy of cholinesterase inhibitors for dysautonomia and chronic constipation and to assess whether acute effects could predict the long term response...
  52. pmc Effects of glucagon-like peptide-1, yohimbine, and nitrergic modulation on sympathetic and parasympathetic activity in humans
    Adil E Bharucha
    Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Clinic, 200 First St S W, Rochester, MN 55905, USA
    Am J Physiol Regul Integr Comp Physiol 295:R874-80. 2008
    ..GLP-1 increases skeletal muscle sympathetic nerve activity but does not appear to affect cardiac sympathetic or parasympathetic activity in humans...
  53. pmc Characterization of ganglionic acetylcholine receptor autoantibodies
    Steven Vernino
    Department of Neurology, UT Southwestern Medical Center, Dallas Texas 75390 9036, United States
    J Neuroimmunol 197:63-9. 2008
    ..Muscle and ganglionic AChR antibody specificities are distinct. Antibody crossreactivity between AChRs with different alpha subunits is uncommon but can occur...
  54. pmc Invited Article: Autonomic ganglia: target and novel therapeutic tool
    Steven Vernino
    Department of Neurology, UT Southwestern Medical Center, Dallas, TX, USA
    Neurology 70:1926-32. 2008
    ..Recent evidence also suggests a potential role for acetylcholinesterase inhibitors in the treatment of postural tachycardia syndrome...
  55. doi request reprint Prevalence of orthostatic hypotension
    Phillip A Low
    Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Clin Auton Res 18:8-13. 2008
    ..The development of OH in normal subjects is associated with an increased mortality rate. OH in diabetes is also associated with a significant increase in mortality rate...
  56. pmc Loss of A5 noradrenergic neurons in multiple system atrophy
    Eduardo E Benarroch
    Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Acta Neuropathol 115:629-34. 2008
    ..The severity of cell loss was comparable to that of locus ceruleus neurons in these cases. Our results indicate that A5 neurons are severely affected in MSA and this may contribute to some of the manifestations of this synucleinopathy...
  57. pmc Decreased peripheral nerve damage after ischemia-reperfusion injury in mice lacking TNF-alpha
    Yanping Wang
    Department of Neurology, Mayo Clinic, Rochester, MN, USA
    J Neurol Sci 267:107-11. 2008
    ..We conclude that TNF-alpha plays an essential role in the pathogenesis of peripheral nerve ischemia-reperfusion injury, possibly partly through the activation of NF-kappaB...
  58. ncbi request reprint Potential outcome measures and trial design issues for multiple system atrophy
    Susanne May
    Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, California 92093 0717, USA
    Mov Disord 22:2371-7. 2007
    ..The UMSARS Motor Examination score exhibited the most favorable characteristics as an outcome measure for a therapeutic trial in MSA with 1 year of follow-up...
  59. pmc Management of neurogenic orthostatic hypotension: an update
    Phillip A Low
    Department of Neurology, Mayo Clinic Rochester, MN 55905, USA
    Lancet Neurol 7:451-8. 2008
    ....
  60. ncbi request reprint Impaired glucose tolerance is associated with postganglionic sudomotor impairment
    Andrew Grandinetti
    Clin Auton Res 17:231-3. 2007
    ..Responses were significantly impaired in those with IGT, which may be indicative of early distal small fiber neuropathy...
  61. ncbi request reprint Arterial baroreflex control of heart rate during exercise in postural tachycardia syndrome
    Shizue Masuki
    Department of Anesthesiology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    J Appl Physiol 103:1136-42. 2007
    ..These results suggest that the tachycardia during exercise in POTS was not due to abnormal baroreflex control of HR...
  62. ncbi request reprint Effect of age on adrenergic and vagal baroreflex sensitivity in normal subjects
    Chih Cheng Huang
    Mayo Clinic, Department of Neurology, 200 First Street SW, Rochester, Minnesota 55905, USA
    Muscle Nerve 36:637-42. 2007
    ..The adrenergic parameters correlated well with each other but not significantly with BRS-v. The results indicate that both BRS-a and BRS-v become blunted with increasing age and that these indices behave independently of each other...
  63. ncbi request reprint Reduced stroke volume during exercise in postural tachycardia syndrome
    Shizue Masuki
    Department of Anesthesiology, Mayo Clinic Foundation, Rochester, MN 55905, USA
    J Appl Physiol 103:1128-35. 2007
    ..60), and 75 W (R(2) = 0.32) (P < 0.01). These results suggest that greater elevation in HR in POTS patients during exercise, especially while upright, was secondary to reduced SV and associated with exercise intolerance...
  64. ncbi request reprint Postural orthostatic tachycardia syndrome: anesthetic implications in the obstetric patient
    Matthew D McEvoy
    Department of Anesthesiology and Perioperative Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Anesth Analg 104:166-7. 2007
    ..We discuss anesthetic concerns with this disease in the parturient and suggest approaches for management of this disease...
  65. ncbi request reprint Pyridostigmine treatment trial in neurogenic orthostatic hypotension
    Wolfgang Singer
    Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Arch Neurol 63:513-8. 2006
    ..By enhancing ganglionic transmission, pyridostigmine bromide can potentially ameliorate OH without worsening supine hypertension...
  66. ncbi request reprint A randomized, controlled exploratory study of clonidine in diarrhea-predominant irritable bowel syndrome
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Gastroenterology Research Unit, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Clin Gastroenterol Hepatol 1:111-21. 2003
    ....
  67. ncbi request reprint Involvement of medullary serotonergic groups in multiple system atrophy
    Eduardo E Benarroch
    Department of Neurology, Mayo Clinic, 811 Guggenheim Building, 200 First Street SW, Rochester, MN 55905, USA
    Ann Neurol 55:418-22. 2004
    ..Depletion of serotonergic neurons may contribute to impaired control of sympathetic outflow and other abnormalities in MSA...
  68. ncbi request reprint Idiopathic autonomic neuropathy: comparison of cases seropositive and seronegative for ganglionic acetylcholine receptor antibody
    Paola Sandroni
    Department of Neurology, Mayo Foundation, Guggenheim 811, 200 First Street SW, Rochester, MN 55905, USA
    Arch Neurol 61:44-8. 2004
    ....
  69. ncbi request reprint Correlates of functional disability in patients with postural tachycardia syndrome: preliminary cross-sectional findings
    Lisa M Benrud-Larson
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Health Psychol 22:643-8. 2003
    ..Results suggest that modifiable psychological factors play a role in the functional limitations experienced by patients with POTS. Longitudinal research is necessary to confirm these relationships...
  70. ncbi request reprint Erythromelalgia: vasculopathy, neuropathy, or both? A prospective study of vascular and neurophysiologic studies in erythromelalgia
    Mark D P Davis
    Department of Dermatology, Mayo Clinic, Rochester, MN 55905, USA
    Arch Dermatol 139:1337-43. 2003
    ..To assess the frequency and type of vascular changes and neurologic abnormalities in patients with erythromelalgia...
  71. ncbi request reprint Orthostatic headaches without CSF leak in postural tachycardia syndrome
    Bahram Mokri
    Department of Neurology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Neurology 61:980-2. 2003
    ..Orthostatic headaches are not always caused by CSF leak or supine intracranial hypotension. Occasionally they may be the major clinical manifestation of postural tachycardia syndrome or orthostatic intolerance...
  72. ncbi request reprint Depletion of ventromedullary NK-1 receptor-immunoreactive neurons in multiple system atrophy
    Eduardo E Benarroch
    Department of Neurology, Mayo Foundation, Rochester, MN 55904, USA
    Brain 126:2183-90. 2003
    ....
  73. ncbi request reprint Acute hemodynamic effects of abdominal exercise with and without breath holding
    Jonathan T Finnoff
    Sports Medicien Center, Mayo Clinic, Rochester, MN 55905, USA
    Arch Phys Med Rehabil 84:1017-22. 2003
    ....
  74. ncbi request reprint The spectrum of autoimmune autonomic neuropathies
    Caroline M Klein
    Department of Neurology, Medical University of South Carolina, Charleston, SC, USA
    Ann Neurol 53:752-8. 2003
    ....
  75. ncbi request reprint Experimental autoimmune autonomic neuropathy
    Steven Vernino
    Department of Neurology, Mayo Graduate and Medical Schools, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Neurophysiol 90:2053-9. 2003
    ..These findings define the autonomic physiology and histopathology of this novel animal model and support the concept that AAN in humans is a disorder of ganglionic cholinergic synaptic transmission caused by ganglionic nAChR antibodies...
  76. ncbi request reprint Effects of linearly polarized 0.6-1.6 microM irradiation on stellate ganglion function in normal subjects and people with complex regional pain (CRPS I)
    Jeffrey R Basford
    Department of Physical Medicine and Rehabilitation, Autonomic Disorder Center, Mayo Clinic and Foundation, 200 Southwest Second Street, Rochester, Minnesota 55905, USA
    Lasers Surg Med 32:417-23. 2003
    ..This study was designed to assess the physiological effects of this latter approach and to quantitate its benefits in people with upper extremity pain due to Complex Regional Pain Syndrome I (CRPS I, RSD)...
  77. ncbi request reprint Complex regional pain syndrome type I: incidence and prevalence in Olmsted county, a population-based study
    Paola Sandroni
    Mayo Clinic, Rochester, MN 55905, USA
    Pain 103:199-207. 2003
    ..These results suggest that invasive treatment of CRPS may not be warranted in the majority of cases...
  78. ncbi request reprint Heart rate-dependent electrocardiogram abnormalities in patients with postural tachycardia syndrome
    Wolfgang Singer
    Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Auton Neurosci 103:106-13. 2003
    ..These findings may reflect intrinsic cardiac electrophysiologic abnormalities or may be secondary due to abnormalities of cardiac autonomic innervation...
  79. ncbi request reprint Autonomic neuropathies
    Phillip A Low
    Department of Neurology, Mayo Medical School, Mayo Clinic, Rochester, Minnesota 55905, USA
    Curr Opin Neurol 15:605-9. 2002
    ..To update recent advances in the pathogenesis, pathophysiology and treatment of some autonomic neuropathies...
  80. ncbi request reprint Quality of life in patients with postural tachycardia syndrome
    Lisa M Benrud-Larson
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 77:531-7. 2002
    ..To quantify quality of life and identify demographic and clinical correlates of functioning in a well-characterized sample of patients with postural tachycardia syndrome (POTS)...
  81. ncbi request reprint Evidence of an intrinsic sinus node abnormality in patients with postural tachycardia syndrome
    Wolfgang Singer
    Department of Neurology, Mayo Clinic, Rochester, Minn 55905, USA
    Mayo Clin Proc 77:246-52. 2002
    ....
  82. ncbi request reprint Testing the autonomic nervous system
    Phillip A Low
    Department of Neurology, Mayo Foundation, Rochester, Minnesota 55905, USA
    Semin Neurol 23:407-21. 2003
    ....
  83. ncbi request reprint Evaluation of sudomotor function
    Phillip A Low
    Department of Neurology, Mayo Foundation, 811 Guggenheim, 200 First Street SW, Rochester, MN 55905, USA
    Clin Neurophysiol 115:1506-13. 2004
  84. ncbi request reprint Use of lower abdominal compression to combat orthostatic hypotension in patients with autonomic dysfunction
    Adrianus A J Smit
    Dept of Internal Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Clin Auton Res 14:167-75. 2004
    ..05). We conclude that in patients with neurogenic orthostatic hypotension, abdominal compression increases standing blood pressure to a varying degree by increasing stroke volume...
  85. ncbi request reprint Blood pressure recovery from Valsalva maneuver in patients with autonomic failure
    Elizabeth R Vogel
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 65:1533-7. 2005
    ..Blood pressure (BP) changes in response to the Valsalva maneuver (VM) reflect the integrity of the baroreflex that regulates BP, and the phases of VM are widely used indices of adrenergic evaluation...
  86. ncbi request reprint Inappropriate sinus tachycardia, postural orthostatic tachycardia syndrome, and overlapping syndromes
    Peter A Brady
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic College of Medicine and Mayo Foundation, Rochester, Minnesota 55905, USA
    Pacing Clin Electrophysiol 28:1112-21. 2005
    ..Pathogenesis of these overlapping syndromes is poorly understood. Diagnostic and therapeutic approaches have not been standardized...
  87. ncbi request reprint Laboratory evaluation of autonomic function
    Phillip A Low
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Suppl Clin Neurophysiol 57:358-68. 2004
  88. ncbi request reprint A screen of candidate genes and influence of beta2-adrenergic receptor genotypes in postural tachycardia syndrome
    Kim K Nickander
    Department of Neurology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, Minnesota 55905, USA
    Auton Neurosci 120:97-103. 2005
    ....
  89. ncbi request reprint What is the minimum duration of head-up tilt necessary to detect orthostatic hypotension?
    Jade A Gehrking
    Dept of Neurology, Mayo Clinic, Rochester MN 55905, USA
    Clin Auton Res 15:71-5. 2005
    ..The purpose of the current study was 1) to determine the minimum duration of HUT necessary to detect OH and 2) to identify different patterns of orthostatic blood pressure (BP) response in patients with OH...
  90. ncbi request reprint Depressive symptoms and life satisfaction in patients with multiple system atrophy
    Lisa M Benrud-Larson
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55095, USA
    Mov Disord 20:951-7. 2005
    ..Adequate treatment of comorbid depression may improve quality of life in this population, despite the presence of other debilitating deficits...
  91. ncbi request reprint Pyridostigmine for treatment of neurogenic orthostatic hypotension [correction of hypertension]--a follow-up survey study
    Paola Sandroni
    Autonomic Disorders Center, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Clin Auton Res 15:51-3. 2005
    ..Aim of the study was to evaluate self-reported efficacy and patients' satisfaction with the medication. Most patients were very satisfied with the medication and chose to continue it...
  92. ncbi request reprint Morphometry of dorsal root ganglion in chronic experimental diabetic neuropathy
    Motoko Kishi
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Diabetes 51:819-24. 2002
    ....
  93. ncbi request reprint Spectral analysis of slow modulation of EEG amplitude and cardiovascular variables in subjects with postural tachycardia syndrome
    Terrence D Lagerlund
    Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States
    Auton Neurosci 117:132-42. 2005
    ....
  94. ncbi request reprint Involvement of medullary regions controlling sympathetic output in Lewy body disease
    Eduardo E Benarroch
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Brain 128:338-44. 2005
    ..In LBD, orthostatic hypotension may be due primarily to involvement of sympathetic ganglion neurons rather than ventrolateral medulla neurons...
  95. ncbi request reprint Autonomic symptoms and diabetic neuropathy: a population-based study
    Phillip A Low
    Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Diabetes Care 27:2942-7. 2004
    ....
  96. ncbi request reprint Ischemia-reperfusion injury of peripheral nerve in experimental diabetic neuropathy
    Yanping Wang
    Department of Neurology, Mayo Clinic, 811 Guggenheim, 200 First Street SW, Rochester, MN 55905, USA
    J Neurol Sci 227:101-7. 2004
    ..Reperfusion exaggerated morphological pathology in 1-month STZ-induced diabetic peripheral nerve...
  97. ncbi request reprint Zonisamide and associated oligohidrosis and hyperthermia
    Phillip A Low
    Department of Neurology, Mayo Clinic College of Medicine, 811 Guggenheim Building, Rochester, MN 55905, USA
    Epilepsy Res 62:27-34. 2004
    ..In each case, oligohidrosis was reversible upon discontinuation of zonisamide. Ensuring that children remain cool and well hydrated during hot weather can minimize the potential for hyperthermia resulting from oligohidrosis...
  98. ncbi request reprint Pacing does not improve hypotension in patients with severe orthostatic hypotension--a prospective randomized cross-over pilot study
    Zakir H Sahul
    Dept of Internal Medicine, Mayo Clinic and Foundation, Rochester MN, USA
    Clin Auton Res 14:255-8. 2004
    ..To date, however, no randomized controlled studies have been performed to validate the approach...
  99. ncbi request reprint Myeloneuropathy and anemia due to copper malabsorption
    Neeraj Kumar
    Department of Neurology, E8A Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    J Neurol 251:747-9. 2004
    ..The limited literature on neurological manifestations of acquired copper deficiency suggests that the clinical presentation resembles the myeloneuropathy seen with vitamin B12 deficiency...
  100. pmc Passive transfer of autoimmune autonomic neuropathy to mice
    Steven Vernino
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Neurosci 24:7037-42. 2004
    ..The antibody effect is potentially reversible, justifying early use of immunomodulatory therapy directed at lowering IgG levels and abrogating IgG production in patients with AAN...
  101. ncbi request reprint Vasovagal syncope in patients with reduced left ventricular function
    Christopher M Stanton
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Clin Auton Res 17:33-8. 2007
    ..Although this study had a small cohort size, the predominantly vasodepressor response without a cardioinhibitory component warrants further investigation into mechanisms of VVS in these patients...