Gwen A Lomberk
Affiliation: Mayo Clinic
Lomberk G, Urrutia R. The Triple-Code Model for Pancreatic Cancer: Cross Talk Among Genetics, Epigenetics, and Nuclear Structure. Surg Clin North Am. 2015;95:935-52 pubmed publisher
..Epigenetic alterations are amenable to pharmacologic manipulations, thus this new integrated paradigm will contribute to advance this field from a mechanistic and translational point of view. ..
Grzenda A, Leonard P, Seo S, Mathison A, Urrutia G, Calvo E, et al
. Functional impact of Aurora A-mediated phosphorylation of HP1? at serine 83 during cell cycle progression. Epigenetics Chromatin. 2013;6:21 pubmed publisher
Velez G, Lin M, Christensen T, Faubion W, Lomberk G, Urrutia R. Evidence supporting a critical contribution of intrinsically disordered regions to the biochemical behavior of full-length human HP1Î³. J Mol Model. 2016;22:12 pubmed publisher
..Combined, these data underscore the importance of IDRs 1, 2, and 3 in defining the structural and dynamic properties of HP1Î³, discoveries that have both mechanistic and potentially biomedical relevance. ..
Lomberk G, Mathison A, Grzenda A, Seo S, DeMars C, Rizvi S, et al
. Sequence-specific recruitment of heterochromatin protein 1 via interaction with Krüppel-like factor 11, a human transcription factor involved in tumor suppression and metabolic diseases. J Biol Chem. 2012;287:13026-39 pubmed publisher
Leonard P, Grzenda A, Mathison A, Morbeck D, Fredrickson J, de Assuncao T, et al
. The Aurora A-HP1Î³ pathway regulates gene expression and mitosis in cells from the sperm lineage. BMC Dev Biol. 2015;15:23 pubmed publisher
..Combined, this data is relevant to better understanding the function of HP1Î³ in reproductive biology. ..
Mathison A, Salmonson A, Missfeldt M, Bintz J, Williams M, Kossak S, et al
. Combined AURKA and H3K9 Methyltransferase Targeting Inhibits Cell Growth By Inducing Mitotic Catastrophe. Mol Cancer Res. 2017;15:984-997 pubmed publisher
..i>Mol Cancer Res; 15(8); 984-97. ©2017 AACR. ..