Research Topics
Genomes and Genes | Gwen A LomberkSummaryAffiliation: Mayo Clinic Country: USA Publications
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Publications
Sequence-specific recruitment of heterochromatin protein 1 via interaction with Krüppel-like factor 11, a human transcription factor involved in tumor suppression and metabolic diseasesGwen Lomberk
Department of Biochemistry and Molecular Biology, Laboratory of Epigenetics and Chromatin Dynamics, GIH Division, Mayo Clinic, Rochester, Minnesota 55905, USA
J Biol Chem 287:13026-39. 2012....
DiabetesGwen Lomberk
Gastroenterology Research Unit, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Pancreatology 9:200-2. 2009..Therefore, in this issue of Pancreatology and the Web, we explore the topic of diabetes to keep us alert to this very important association, even if we study diseases of the exocrine pancreas...- Patient advocacyGwen Lomberk
Gastroenterology Research Unit, Saint Mary s Hospital, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Pancreatology 8:420-1. 2008..The human factor should never be erased from our thoughts... - Pain managementGwen Lomberk
Gastroenterology Research Unit, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Pancreatology 8:542-3. 2008..In patients with unresectable pancreatic cancer, severe abdominal and back pain is a significant complication due to the spread of the disease to nerves in the surrounding area or pressure on nearby organs... 
2010-2011 meetings and conferencesGwen Lomberk
Gastroenterology Research Unit, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
Pancreatology 10:413-5. 2010..and IAP...- Educational websites--Bioinformatics Tools IIGwen Lomberk
Gastroenterology Research Unit, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Pancreatology 9:4-5. 2009.... - Primers on molecular pathways--caspase pathwayGwen Lomberk
Division of Gastroenterology, Mayo Clinic, Rochester, MN 55905, USA
Pancreatology 9:6-8. 2009..Thus, it is for these reasons that in the current 'Primers on Molecular Pathways,' we take a closer look at the pathway cascade that is triggered during apoptosis... - AngiogenesisGwen Lomberk
Gastroenterology Research Unit, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Pancreatology 10:112-3. 2010..Therefore, to extend our knowledge of the tumor microenvironment from our previous issue on the extracellular matrix, this Pancreatology and the Web article focuses on angiogenesis. and IAP... - MicroscopyGwen Lomberk
Gastroenterology Research Unit, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Pancreatology 9:554-5. 2009..The development of microscopy revolutionized biology and, to this day, remains an essential tool in science... - Funding opportunities for rare pancreatic diseasesGwen Lomberk
Gastroenterology Research Unit, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
Pancreatology 9:327-8. 2009..For these reasons, we provide the following websites that deal with funding sources to hopefully serve as a useful place to request funding for rare pancreatic diseases. and IAP... - SocietiesGwen Lomberk
Gastroenterology Research Unit, Saint Mary s Hospital, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Pancreatology 8:225-6. 2008..and IAP... - Primers on molecular pathways--notchGwen Lomberk
Gastroenterology Research Unit, Saint Mary s Hospital, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Pancreatology 8:103-4. 2008.... - Animal modelsGwen Lomberk
Gastroenterology Research Unit, Saint Mary s Hospital, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Pancreatology 6:427-8. 2006..In particular, websites containing information on mouse, rat, swine, zebra fish and xenopus models will be discussed due to their direct utility in pancreatic research... - Epigenetic silencing of tumor suppressor genes in pancreatic cancerGwen A Lomberk
Laboratory of Epigenetics and Chromatin Dynamics, Gastroenterology Research Unit, 10 24C Guggenheim Building, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
J Gastrointest Cancer 42:93-9. 2011..This knowledge will help the reader in determining the breadth and depth of this field of study with potentially high impact to oncology... - Laboratory skillsGwen Lomberk
Gastroenterology Research Unit, Saint Mary s Hospital, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Pancreatology 7:7-8. 2007.... - Alcohol and pancreasGwen Lomberk
Gastroenterology Research Unit, Saint Mary s Hospital, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Pancreatology 7:96-7. 2007.... - Stem cellsGwen Lomberk
Gastroenterology Research Unit, Saint Mary s Hospital, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
Pancreatology 7:314-6. 2007.... - EpigeneticsGwen Lomberk
Gastroenterology Research Unit, Saint Mary s Hospital, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Pancreatology 7:396-7. 2007.... - PharmacogenomicsGwen Lomberk
Gastroenterology Research Unit, Saint Mary s Hospital, Mayo Clinic College of Medicine, Rochester, Minn, USA
Pancreatology 8:4-5. 2008..This field has the potential to significantly impact on the way the MD prescribes medicines to patients in the future, improving upon the quality of care that we can provide. and IAP... - Primers on molecular pathways--the insulin pathwayGwen Lomberk
GI Research Unit, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA
Pancreatology 9:203-5. 2009..In this 'Primers on Molecular Pathways', we discuss this important signaling pathway, which is central to pancreas biology... - Detailed structural-functional analysis of the Krüppel-like factor 16 (KLF16) transcription factor reveals novel mechanisms for silencing Sp/KLF sites involved in metabolism and endocrinologyGaurang S Daftary
Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota 55905, USA
J Biol Chem 287:7010-25. 2012..These data also contribute to the new functional information that is applicable to understanding KLF16 and other highly related KLF proteins... - A Novel Role of the Sp/KLF Transcription Factor KLF11 in Arresting Progression of EndometriosisGaurang S Daftary
Laboratory of Translational Epigenetics in Reproduction, Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota, United States of America
PLoS ONE 8:e60165. 2013.... - Lipid biologyGwen Lomberk
Gastroenterology Research Unit, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA lomberk gwen mayo edu
Pancreatology 9:722-3. 2009..Therefore, lipid biology is important in the context of the pancreas, both during our normal digestive process and its impact on diseases affecting the pancreas, such as diabetes, pancreatitis, and cancer... - The sunset of somatic genetics and the dawn of epigenetics: a new frontier in pancreatic cancer researchGwen Lomberk
Laboratory of Chromatin Dynamics and Epigenetics, Gastroenterology Research Unit, Departments of Biochemistry and Molecular Biology, Biophysics and Medicine, Mayo Clinic, Rochester, MN 55901, USA
Curr Opin Gastroenterol 24:597-602. 2008..Therefore, epigenetics with its molecular basis (DNA methylation and chromatin modification) is among the most promising areas of cancer research and is a nascent field in pancreatic cancer research... - Distinct role of Kruppel-like factor 11 in the regulation of prostaglandin E2 biosynthesisNavtej S Buttar
Division of Gastroenterology, Mayo Clinic, Rochester, Minnesota 55902, USA
J Biol Chem 285:11433-44. 2010.... - Insights into the epigenetic mechanisms controlling pancreatic carcinogenesisAngela L McCleary-Wheeler
Schulze Center for Novel Therapeutics, Division of Oncology Research, Department of Oncology, Rochester, MN, USA
Cancer Lett 328:212-21. 2013..Given this nature of epigenetic alterations, it becomes imperative that our understanding of epigenetic-based events promoting and maintaining PDAC continues to grow... - Evidence for the existence of an HP1-mediated subcode within the histone codeGwen Lomberk
Gastroenterology Research Unit, Department of Medicine, and Mayo Clinic Cancer Center, Rochester, MN 55605, USA
Nat Cell Biol 8:407-15. 2006.... - Polycomb antagonizes p300/CREB-binding protein-associated factor to silence FOXP3 in a Kruppel-like factor-dependent mannerYuning Xiong
Chromatin Dynamics and Epigenetics Laboratory, Mayo Clinic, Rochester, Minnesota 55905, USA
J Biol Chem 287:34372-85. 2012..These results provide insight into chromatin remodeling events key to phenotypic features of distinct T cell populations... - A functional family-wide screening of SP/KLF proteins identifies a subset of suppressors of KRAS-mediated cell growthMartin E Fernandez-Zapico
Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55901, USA
Biochem J 435:529-37. 2011.... - Inhibition of histone deacetylation potentiates the evolution of acquired temozolomide resistance linked to MGMT upregulation in glioblastoma xenograftsGaspar J Kitange
Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota 55905, USA
Clin Cancer Res 18:4070-9. 2012..The therapeutic benefit of temozolomide in glioblastoma multiforme (GBM) is limited by resistance. The goal of this study was to elucidate mechanisms of temozolomide resistance in GBM... - Conservation of the TGFbeta/Labial homeobox signaling loop in endoderm-derived cells between Drosophila and mammalsGwen A Lomberk
Department of Medicine, Mayo Clinic, Rochester, Minn, USA
Pancreatology 10:74-84. 2010..Interestingly, although Labial-like homeobox genes are present in mammals, their participation in endoderm morphogenesis is not clearly understood... - Primers on molecular pathways--pain and opioid receptors, IGwen Lomberk
GI Research Unit, Division of Gastroenterology, Mayo Clinic, Rochester, MN 55905, USA
Pancreatology 8:544-5. 2008.... - Combinatorial chemoprevention reveals a novel smoothened-independent role of GLI1 in esophageal carcinogenesisSumera Rizvi
Division of Gastroenterology and Hepatology, Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, MN, USA
Cancer Res 70:6787-96. 2010..Collectively, these results identify a novel GLI1-to-CDK2 pathway in esophageal carcinogenesis, which is a bona fide target for effective combinatorial chemoprevention with Urso and Aspirin... - The extracellular matrix and cell migrationGwen Lomberk
Gastroenterology Research Unit, Mayo Clinic College of Medicine, Rochester, Minn, USA lomberk gwen mayo edu
Pancreatology 10:4-5. 2010..Therefore, this 'Pancreatology and the Web' focuses on websites that provide information on the ECM and cell migration. and IAP... - The Heterochromatin Protein 1 familyGwen Lomberk
Gastroenterology Research Unit, Saint Mary's Hospital, Mayo Clinic, Rochester, MN 55905, USA
Genome Biol 7:228. 2006..HP1 proteins are amenable to posttranslational modifications that probably regulate these distinct functions, thereby creating a subcode within the context of the 'histone code' of histone posttranslational modifications... - The family feud: turning off Sp1 by Sp1-like KLF proteinsGwen Lomberk
Gastroenterology Research Unit, Mayo Clinic, Rochester, MN 55901, USA
Biochem J 392:1-11. 2005..The existence of these transcriptional repressors provides a tightly regulated mechanism for silencing a large number of genes that are already known to be activated by Sp1... - Silencing of the transforming growth factor-beta (TGFbeta) receptor II by Kruppel-like factor 14 underscores the importance of a negative feedback mechanism in TGFbeta signalingMark J Truty
Department of Biochemistry and Molecular Biology, Gastroenterology Research Unit, Mayo Clinic, Rochester, MN 55905, USA
J Biol Chem 284:6291-300. 2009.... - Sin3: master scaffold and transcriptional corepressorAdrienne Grzenda
Department of Biochemistry, Mayo Clinic, Rochester, MN 55905, USA
Biochim Biophys Acta 1789:443-50. 2009..Abnormal recruitment of this complex or alteration of its enzymatic activity has been implicated in neoplastic transformation... - When developmental signaling pathways go wrong and their impact on pancreatic cancer developmentGwen Lomberk
Gastroenterology Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
Curr Opin Gastroenterol 21:555-60. 2005..SUMMARY: This conceptual validation of previous experiments has fuelled new studies, the results of which will be the focus of this review...