Gwen A Lomberk

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. Lomberk G, Urrutia R. The Triple-Code Model for Pancreatic Cancer: Cross Talk Among Genetics, Epigenetics, and Nuclear Structure. Surg Clin North Am. 2015;95:935-52 pubmed publisher
    ..Epigenetic alterations are amenable to pharmacologic manipulations, thus this new integrated paradigm will contribute to advance this field from a mechanistic and translational point of view. ..
  2. Grzenda A, Leonard P, Seo S, Mathison A, Urrutia G, Calvo E, et al. Functional impact of Aurora A-mediated phosphorylation of HP1? at serine 83 during cell cycle progression. Epigenetics Chromatin. 2013;6:21 pubmed publisher
  3. Velez G, Lin M, Christensen T, Faubion W, Lomberk G, Urrutia R. Evidence supporting a critical contribution of intrinsically disordered regions to the biochemical behavior of full-length human HP1γ. J Mol Model. 2016;22:12 pubmed publisher
    ..Combined, these data underscore the importance of IDRs 1, 2, and 3 in defining the structural and dynamic properties of HP1γ, discoveries that have both mechanistic and potentially biomedical relevance. ..
  4. Lomberk G, Mathison A, Grzenda A, Seo S, DeMars C, Rizvi S, et al. Sequence-specific recruitment of heterochromatin protein 1 via interaction with Krüppel-like factor 11, a human transcription factor involved in tumor suppression and metabolic diseases. J Biol Chem. 2012;287:13026-39 pubmed publisher
  5. Leonard P, Grzenda A, Mathison A, Morbeck D, Fredrickson J, de Assuncao T, et al. The Aurora A-HP1γ pathway regulates gene expression and mitosis in cells from the sperm lineage. BMC Dev Biol. 2015;15:23 pubmed publisher
    ..Combined, this data is relevant to better understanding the function of HP1γ in reproductive biology. ..
  6. Mathison A, Salmonson A, Missfeldt M, Bintz J, Williams M, Kossak S, et al. Combined AURKA and H3K9 Methyltransferase Targeting Inhibits Cell Growth By Inducing Mitotic Catastrophe. Mol Cancer Res. 2017;15:984-997 pubmed publisher
    ..i>Mol Cancer Res; 15(8); 984-97. ©2017 AACR. ..