Gwen A Lomberk

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Functional characterization of EZH2β reveals the increased complexity of EZH2 isoforms involved in the regulation of mammalian gene expression
    Adrienne Grzenda
    Laboratory of Epigenetics and Chromatin Dynamics, Mayo Clinic, Rochester, MN, 55905, USA
    Epigenetics Chromatin 6:3. 2013
  2. pmc Sequence-specific recruitment of heterochromatin protein 1 via interaction with Krüppel-like factor 11, a human transcription factor involved in tumor suppression and metabolic diseases
    Gwen Lomberk
    Department of Biochemistry and Molecular Biology, Laboratory of Epigenetics and Chromatin Dynamics, GIH Division, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Biol Chem 287:13026-39. 2012
  3. doi request reprint Educational websites--Bioinformatics Tools II
    Gwen Lomberk
    Gastroenterology Research Unit, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Pancreatology 9:4-5. 2009
  4. doi request reprint Primers on molecular pathways--caspase pathway
    Gwen Lomberk
    Division of Gastroenterology, Mayo Clinic, Rochester, MN 55905, USA
    Pancreatology 9:6-8. 2009
  5. doi request reprint Diabetes
    Gwen Lomberk
    Gastroenterology Research Unit, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Pancreatology 9:200-2. 2009
  6. doi request reprint Primers on molecular pathways--the insulin pathway
    Gwen Lomberk
    GI Research Unit, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA
    Pancreatology 9:203-5. 2009
  7. doi request reprint Funding opportunities for rare pancreatic diseases
    Gwen Lomberk
    Gastroenterology Research Unit, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Pancreatology 9:327-8. 2009
  8. doi request reprint Microscopy
    Gwen Lomberk
    Gastroenterology Research Unit, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Pancreatology 9:554-5. 2009
  9. doi request reprint Angiogenesis
    Gwen Lomberk
    Gastroenterology Research Unit, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Pancreatology 10:112-3. 2010
  10. ncbi request reprint 2010-2011 meetings and conferences
    Gwen Lomberk
    Gastroenterology Research Unit, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Pancreatology 10:413-5. 2010

Collaborators

Detail Information

Publications41

  1. pmc Functional characterization of EZH2β reveals the increased complexity of EZH2 isoforms involved in the regulation of mammalian gene expression
    Adrienne Grzenda
    Laboratory of Epigenetics and Chromatin Dynamics, Mayo Clinic, Rochester, MN, 55905, USA
    Epigenetics Chromatin 6:3. 2013
    ..Deregulation of EZH2 expression is implicated in numerous complex human diseases. To date, most EZH2-mediated function has been primarily ascribed to a single protein product of the EZH2 locus...
  2. pmc Sequence-specific recruitment of heterochromatin protein 1 via interaction with Krüppel-like factor 11, a human transcription factor involved in tumor suppression and metabolic diseases
    Gwen Lomberk
    Department of Biochemistry and Molecular Biology, Laboratory of Epigenetics and Chromatin Dynamics, GIH Division, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Biol Chem 287:13026-39. 2012
    ....
  3. doi request reprint Educational websites--Bioinformatics Tools II
    Gwen Lomberk
    Gastroenterology Research Unit, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Pancreatology 9:4-5. 2009
    ....
  4. doi request reprint Primers on molecular pathways--caspase pathway
    Gwen Lomberk
    Division of Gastroenterology, Mayo Clinic, Rochester, MN 55905, USA
    Pancreatology 9:6-8. 2009
    ..Thus, it is for these reasons that in the current 'Primers on Molecular Pathways,' we take a closer look at the pathway cascade that is triggered during apoptosis...
  5. doi request reprint Diabetes
    Gwen Lomberk
    Gastroenterology Research Unit, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Pancreatology 9:200-2. 2009
    ..Therefore, in this issue of Pancreatology and the Web, we explore the topic of diabetes to keep us alert to this very important association, even if we study diseases of the exocrine pancreas...
  6. doi request reprint Primers on molecular pathways--the insulin pathway
    Gwen Lomberk
    GI Research Unit, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA
    Pancreatology 9:203-5. 2009
    ..In this 'Primers on Molecular Pathways', we discuss this important signaling pathway, which is central to pancreas biology...
  7. doi request reprint Funding opportunities for rare pancreatic diseases
    Gwen Lomberk
    Gastroenterology Research Unit, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Pancreatology 9:327-8. 2009
    ..For these reasons, we provide the following websites that deal with funding sources to hopefully serve as a useful place to request funding for rare pancreatic diseases. and IAP...
  8. doi request reprint Microscopy
    Gwen Lomberk
    Gastroenterology Research Unit, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Pancreatology 9:554-5. 2009
    ..The development of microscopy revolutionized biology and, to this day, remains an essential tool in science...
  9. doi request reprint Angiogenesis
    Gwen Lomberk
    Gastroenterology Research Unit, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Pancreatology 10:112-3. 2010
    ..Therefore, to extend our knowledge of the tumor microenvironment from our previous issue on the extracellular matrix, this Pancreatology and the Web article focuses on angiogenesis. and IAP...
  10. ncbi request reprint 2010-2011 meetings and conferences
    Gwen Lomberk
    Gastroenterology Research Unit, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Pancreatology 10:413-5. 2010
    ..and IAP...
  11. doi request reprint Epigenetic silencing of tumor suppressor genes in pancreatic cancer
    Gwen A Lomberk
    Laboratory of Epigenetics and Chromatin Dynamics, Gastroenterology Research Unit, 10 24C Guggenheim Building, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Gastrointest Cancer 42:93-9. 2011
    ..In fact, chromatin dynamics and small RNAs are altered far more prevalently in cancer than genetic alterations and most important, can be reversible, lending themselves as attractive therapeutic targets...
  12. doi request reprint Pain management
    Gwen Lomberk
    Gastroenterology Research Unit, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Pancreatology 8:542-3. 2008
    ..In patients with unresectable pancreatic cancer, severe abdominal and back pain is a significant complication due to the spread of the disease to nerves in the surrounding area or pressure on nearby organs...
  13. doi request reprint Patient advocacy
    Gwen Lomberk
    Gastroenterology Research Unit, Saint Mary s Hospital, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Pancreatology 8:420-1. 2008
    ..The human factor should never be erased from our thoughts...
  14. doi request reprint Societies
    Gwen Lomberk
    Gastroenterology Research Unit, Saint Mary s Hospital, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Pancreatology 8:225-6. 2008
    ..and IAP...
  15. ncbi request reprint Laboratory skills
    Gwen Lomberk
    Gastroenterology Research Unit, Saint Mary s Hospital, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Pancreatology 7:7-8. 2007
    ....
  16. ncbi request reprint Animal models
    Gwen Lomberk
    Gastroenterology Research Unit, Saint Mary s Hospital, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Pancreatology 6:427-8. 2006
    ..In particular, websites containing information on mouse, rat, swine, zebra fish and xenopus models will be discussed due to their direct utility in pancreatic research...
  17. ncbi request reprint Alcohol and pancreas
    Gwen Lomberk
    Gastroenterology Research Unit, Saint Mary s Hospital, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Pancreatology 7:96-7. 2007
    ....
  18. ncbi request reprint Stem cells
    Gwen Lomberk
    Gastroenterology Research Unit, Saint Mary s Hospital, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Pancreatology 7:314-6. 2007
    ....
  19. ncbi request reprint Epigenetics
    Gwen Lomberk
    Gastroenterology Research Unit, Saint Mary s Hospital, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Pancreatology 7:396-7. 2007
    ....
  20. doi request reprint Pharmacogenomics
    Gwen Lomberk
    Gastroenterology Research Unit, Saint Mary s Hospital, Mayo Clinic College of Medicine, Rochester, Minn, USA
    Pancreatology 8:4-5. 2008
    ..This field has the potential to significantly impact on the way the MD prescribes medicines to patients in the future, improving upon the quality of care that we can provide. and IAP...
  21. doi request reprint Primers on molecular pathways--notch
    Gwen Lomberk
    Gastroenterology Research Unit, Saint Mary s Hospital, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Pancreatology 8:103-4. 2008
    ....
  22. pmc A novel role of the Sp/KLF transcription factor KLF11 in arresting progression of endometriosis
    Gaurang S Daftary
    Laboratory of Translational Epigenetics in Reproduction, Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, USA
    PLoS ONE 8:e60165. 2013
    ....
  23. pmc Detailed structural-functional analysis of the Krüppel-like factor 16 (KLF16) transcription factor reveals novel mechanisms for silencing Sp/KLF sites involved in metabolism and endocrinology
    Gaurang S Daftary
    Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Biol Chem 287:7010-25. 2012
    ..These data also contribute to the new functional information that is applicable to understanding KLF16 and other highly related KLF proteins...
  24. doi request reprint Lipid biology
    Gwen Lomberk
    Gastroenterology Research Unit, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA lomberk gwen mayo edu
    Pancreatology 9:722-3. 2009
    ..Therefore, lipid biology is important in the context of the pancreas, both during our normal digestive process and its impact on diseases affecting the pancreas, such as diabetes, pancreatitis, and cancer...
  25. pmc The sunset of somatic genetics and the dawn of epigenetics: a new frontier in pancreatic cancer research
    Gwen Lomberk
    Laboratory of Chromatin Dynamics and Epigenetics, Gastroenterology Research Unit, Departments of Biochemistry and Molecular Biology, Biophysics and Medicine, Mayo Clinic, Rochester, MN 55901, USA
    Curr Opin Gastroenterol 24:597-602. 2008
    ..Therefore, epigenetics with its molecular basis (DNA methylation and chromatin modification) is among the most promising areas of cancer research and is a nascent field in pancreatic cancer research...
  26. pmc Distinct role of Kruppel-like factor 11 in the regulation of prostaglandin E2 biosynthesis
    Navtej S Buttar
    Division of Gastroenterology, Mayo Clinic, Rochester, Minnesota 55902, USA
    J Biol Chem 285:11433-44. 2010
    ....
  27. pmc Insights into the epigenetic mechanisms controlling pancreatic carcinogenesis
    Angela L McCleary-Wheeler
    Schulze Center for Novel Therapeutics, Division of Oncology Research, Department of Oncology, Rochester, MN, USA
    Cancer Lett 328:212-21. 2013
    ..Given this nature of epigenetic alterations, it becomes imperative that our understanding of epigenetic-based events promoting and maintaining PDAC continues to grow...
  28. ncbi request reprint Evidence for the existence of an HP1-mediated subcode within the histone code
    Gwen Lomberk
    Gastroenterology Research Unit, Department of Medicine, and Mayo Clinic Cancer Center, Rochester, MN 55605, USA
    Nat Cell Biol 8:407-15. 2006
    ....
  29. pmc Membrane-to-nucleus signaling links insulin-like growth factor-1- and stem cell factor-activated pathways
    Yujiro Hayashi
    Enteric Neuroscience Program, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America Gastroenterology Research Unit, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 8:e76822. 2013
    ....
  30. pmc Polycomb antagonizes p300/CREB-binding protein-associated factor to silence FOXP3 in a Kruppel-like factor-dependent manner
    Yuning Xiong
    Chromatin Dynamics and Epigenetics Laboratory, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Biol Chem 287:34372-85. 2012
    ..These results provide insight into chromatin remodeling events key to phenotypic features of distinct T cell populations...
  31. pmc A functional family-wide screening of SP/KLF proteins identifies a subset of suppressors of KRAS-mediated cell growth
    Martin E Fernandez-Zapico
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55901, USA
    Biochem J 435:529-37. 2011
    ....
  32. pmc Inhibition of histone deacetylation potentiates the evolution of acquired temozolomide resistance linked to MGMT upregulation in glioblastoma xenografts
    Gaspar J Kitange
    Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Clin Cancer Res 18:4070-9. 2012
    ..The therapeutic benefit of temozolomide in glioblastoma multiforme (GBM) is limited by resistance. The goal of this study was to elucidate mechanisms of temozolomide resistance in GBM...
  33. pmc Conservation of the TGFbeta/Labial homeobox signaling loop in endoderm-derived cells between Drosophila and mammals
    Gwen A Lomberk
    Department of Medicine, Mayo Clinic, Rochester, Minn, USA
    Pancreatology 10:74-84. 2010
    ..Interestingly, although Labial-like homeobox genes are present in mammals, their participation in endoderm morphogenesis is not clearly understood...
  34. doi request reprint Primers on molecular pathways--pain and opioid receptors, I
    Gwen Lomberk
    GI Research Unit, Division of Gastroenterology, Mayo Clinic, Rochester, MN 55905, USA
    Pancreatology 8:544-5. 2008
    ....
  35. pmc Combinatorial chemoprevention reveals a novel smoothened-independent role of GLI1 in esophageal carcinogenesis
    Sumera Rizvi
    Division of Gastroenterology and Hepatology, Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, MN, USA
    Cancer Res 70:6787-96. 2010
    ..Collectively, these results identify a novel GLI1-to-CDK2 pathway in esophageal carcinogenesis, which is a bona fide target for effective combinatorial chemoprevention with Urso and Aspirin...
  36. doi request reprint The extracellular matrix and cell migration
    Gwen Lomberk
    Gastroenterology Research Unit, Mayo Clinic College of Medicine, Rochester, Minn, USA lomberk gwen mayo edu
    Pancreatology 10:4-5. 2010
    ..Therefore, this 'Pancreatology and the Web' focuses on websites that provide information on the ECM and cell migration. and IAP...
  37. pmc The family feud: turning off Sp1 by Sp1-like KLF proteins
    Gwen Lomberk
    Gastroenterology Research Unit, Mayo Clinic, Rochester, MN 55901, USA
    Biochem J 392:1-11. 2005
    ..The existence of these transcriptional repressors provides a tightly regulated mechanism for silencing a large number of genes that are already known to be activated by Sp1...
  38. pmc Silencing of the transforming growth factor-beta (TGFbeta) receptor II by Kruppel-like factor 14 underscores the importance of a negative feedback mechanism in TGFbeta signaling
    Mark J Truty
    Department of Biochemistry and Molecular Biology, Gastroenterology Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    J Biol Chem 284:6291-300. 2009
    ....
  39. ncbi request reprint When developmental signaling pathways go wrong and their impact on pancreatic cancer development
    Gwen Lomberk
    Gastroenterology Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
    Curr Opin Gastroenterol 21:555-60. 2005
    ..To describe recent studies of developmental signal pathways and their relation to the development of pancreatic cancer...
  40. pmc The Heterochromatin Protein 1 family
    Gwen Lomberk
    Gastroenterology Research Unit, Saint Mary s Hospital, Mayo Clinic, Rochester, MN 55905, USA
    Genome Biol 7:228. 2006
    ..HP1 proteins are amenable to posttranslational modifications that probably regulate these distinct functions, thereby creating a subcode within the context of the 'histone code' of histone posttranslational modifications...
  41. pmc Sin3: master scaffold and transcriptional corepressor
    Adrienne Grzenda
    Department of Biochemistry, Mayo Clinic, Rochester, MN 55905, USA
    Biochim Biophys Acta 1789:443-50. 2009
    ..Abnormal recruitment of this complex or alteration of its enzymatic activity has been implicated in neoplastic transformation...