W L Lingle

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Centrosome amplification drives chromosomal instability in breast tumor development
    Wilma L Lingle
    Division of Experimental Pathology, Tumor Biology Program, Mayo Clinic, Rochester, MN 55905, USA
    Proc Natl Acad Sci U S A 99:1978-83. 2002
  2. doi request reprint Deregulation of the centrosome cycle and the origin of chromosomal instability in cancer
    Wilma L Lingle
    Mayo Clinic College of Medicine, Mayo Clinic Foundation, Mayo Clinic Cancer Center, Rochester, Minnesota 55905, USA
    Adv Exp Med Biol 570:393-421. 2005
  3. pmc Altered centrosome structure is associated with abnormal mitoses in human breast tumors
    W L Lingle
    Tumor Biology Program, Mayo Foundation, Rochester, Minnesota 55905, USA
    Am J Pathol 155:1941-51. 1999
  4. ncbi request reprint Microtubule nucleating capacity of centrosomes in tissue sections
    J L Salisbury
    Tumor Biology Program, Mayo Clinic, Rochester, Minnesota
    J Histochem Cytochem 47:1265-74. 1999
  5. ncbi request reprint Methods for the analysis of centrosome reproduction in cancer cells
    W L Lingle
    Experimental Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Methods Cell Biol 67:325-36. 2001
  6. pmc Phase I trial of autologous hematopoietic SCT with escalating doses of topotecan combined with CY and carboplatin in patients with relapsed or persistent ovarian or primary peritoneal carcinoma
    M R Litzow
    Division of Hematology, Mayo Clinic Cancer Center, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Bone Marrow Transplant 45:490-7. 2010
  7. ncbi request reprint The mitotic checkpoint protein hBUB3 and the mRNA export factor hRAE1 interact with GLE2p-binding sequence (GLEBS)-containing proteins
    X Wang
    Department of Pediatrics and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Biol Chem 276:26559-67. 2001
  8. ncbi request reprint Phosphorylation of centrin during the cell cycle and its role in centriole separation preceding centrosome duplication
    W Lutz
    Department of Biochemistry and Molecular Biology, Tumor Biology Program, Mayo Clinic Foundation, Rochester, Minnesota 55905, USA
    J Biol Chem 276:20774-80. 2001
  9. ncbi request reprint Chronic exposure to lead chromate causes centrosome abnormalities and aneuploidy in human lung cells
    Amie L Holmes
    Wise Laboratory of Environmental and Genetic Toxicology, University of Southern Maine, Portland, Maine, USA
    Cancer Res 66:4041-8. 2006
  10. ncbi request reprint The granulin-epithelin precursor is a steroid-regulated growth factor in endometrial cancer
    Monica Brown Jones
    Mayo Clinic, Gynecologic Surgery, Rochester, Minnesota 55905, USA
    J Soc Gynecol Investig 13:304-11. 2006

Collaborators

Detail Information

Publications33

  1. pmc Centrosome amplification drives chromosomal instability in breast tumor development
    Wilma L Lingle
    Division of Experimental Pathology, Tumor Biology Program, Mayo Clinic, Rochester, MN 55905, USA
    Proc Natl Acad Sci U S A 99:1978-83. 2002
    ..These results further suggest that aspects of centrosome amplification may have clinical diagnostic and/or prognostic value and that the centrosome may be a potential target for cancer therapy...
  2. doi request reprint Deregulation of the centrosome cycle and the origin of chromosomal instability in cancer
    Wilma L Lingle
    Mayo Clinic College of Medicine, Mayo Clinic Foundation, Mayo Clinic Cancer Center, Rochester, Minnesota 55905, USA
    Adv Exp Med Biol 570:393-421. 2005
    ..Centrosome amplification, therefore, can serve to exacerbate and/or generate genetic instabilities associated with cancers...
  3. pmc Altered centrosome structure is associated with abnormal mitoses in human breast tumors
    W L Lingle
    Tumor Biology Program, Mayo Foundation, Rochester, Minnesota 55905, USA
    Am J Pathol 155:1941-51. 1999
    ..Centrosome abnormalities may confer a mutator phenotype to tumors, occasionally yielding cells with a selective advantage that emerge and thrive, thus leading the tumor to a more aggressive state...
  4. ncbi request reprint Microtubule nucleating capacity of centrosomes in tissue sections
    J L Salisbury
    Tumor Biology Program, Mayo Clinic, Rochester, Minnesota
    J Histochem Cytochem 47:1265-74. 1999
    ..These methods can be utilized to characterize MTOC activity in normal and diseased tissues and in particular tissues at different stages of development. (J Histochem Cytochem 47:1265-1273, 1999)..
  5. ncbi request reprint Methods for the analysis of centrosome reproduction in cancer cells
    W L Lingle
    Experimental Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Methods Cell Biol 67:325-36. 2001
    ..This assay can also be used to characterize the microtubule nucleation capacity of normal tissues, during development and aging, and in disease states other than cancer where microtubule dynamics may play an important role...
  6. pmc Phase I trial of autologous hematopoietic SCT with escalating doses of topotecan combined with CY and carboplatin in patients with relapsed or persistent ovarian or primary peritoneal carcinoma
    M R Litzow
    Division of Hematology, Mayo Clinic Cancer Center, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Bone Marrow Transplant 45:490-7. 2010
    ..04). Topotecan can safely be dose escalated to 4.5 mg/m(2)/d in combination with CY, carboplatin and AHSCT. This trial is registered at ClinicalTrials.gov as NCT00652691...
  7. ncbi request reprint The mitotic checkpoint protein hBUB3 and the mRNA export factor hRAE1 interact with GLE2p-binding sequence (GLEBS)-containing proteins
    X Wang
    Department of Pediatrics and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Biol Chem 276:26559-67. 2001
    ..Our findings demonstrate that GLEBS motifs reside in mammalian nucleoporins and mitotic checkpoint proteins and apparently serve as specific binding sites for either BUB3, RAE1, or both...
  8. ncbi request reprint Phosphorylation of centrin during the cell cycle and its role in centriole separation preceding centrosome duplication
    W Lutz
    Department of Biochemistry and Molecular Biology, Tumor Biology Program, Mayo Clinic Foundation, Rochester, Minnesota 55905, USA
    J Biol Chem 276:20774-80. 2001
    ..Taken together, these results suggest that centrin phosphorylation signals the separation of centrosomes at prophase and implicates centrin phosphorylation in centriole separation that normally precedes centrosome duplication...
  9. ncbi request reprint Chronic exposure to lead chromate causes centrosome abnormalities and aneuploidy in human lung cells
    Amie L Holmes
    Wise Laboratory of Environmental and Genetic Toxicology, University of Southern Maine, Portland, Maine, USA
    Cancer Res 66:4041-8. 2006
    ..These data suggest that one possible mechanism for lead chromate-induced carcinogenesis is through centrosome dysfunction, leading to the induction of aneuploidy...
  10. ncbi request reprint The granulin-epithelin precursor is a steroid-regulated growth factor in endometrial cancer
    Monica Brown Jones
    Mayo Clinic, Gynecologic Surgery, Rochester, Minnesota 55905, USA
    J Soc Gynecol Investig 13:304-11. 2006
    ..Once we established the co-expression of GEP with the estrogen receptor we examined the potential estrogen regulation of GEP expression, as well as the functional significance of GEP expression in vitro...
  11. ncbi request reprint HER2 testing by local, central, and reference laboratories in specimens from the North Central Cancer Treatment Group N9831 intergroup adjuvant trial
    Edith A Perez
    Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224, USA
    J Clin Oncol 24:3032-8. 2006
    ..To evaluate concordance between local and central laboratory HER2 testing results in patients from the North Central Cancer Treatment Group (NCCTG) N9831 adjuvant trial of trastuzumab...
  12. ncbi request reprint The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen
    Matthew P Goetz
    Department of Oncology, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, MN, 55905, USA
    Breast Cancer Res Treat 101:113-21. 2007
    ....
  13. pmc Cytochrome P450 2D6 and homeobox 13/interleukin-17B receptor: combining inherited and tumor gene markers for prediction of tamoxifen resistance
    Matthew P Goetz
    Department of Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Clin Cancer Res 14:5864-8. 2008
    ..We sought to determine the combined effect of inherited (CYP2D6) and somatic (HOXB13/IL17BR) gene variation in tamoxifen-treated breast cancer...
  14. ncbi request reprint Aurora a and B overexpression and centrosome amplification in early estrogen-induced tumor foci in the Syrian hamster kidney: implications for chromosomal instability, aneuploidy, and neoplasia
    Adrianne E Hontz
    Hormonal Carcinogenesis Laboratory, Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, USA
    Cancer Res 67:2957-63. 2007
    ....
  15. doi request reprint Association between cyclooxygenase-2 expression in atypical hyperplasia and risk of breast cancer
    Daniel W Visscher
    Department of Surgical Pathology, University of Michigan, Ann Arbor, MI, USA
    J Natl Cancer Inst 100:421-7. 2008
    ..Atypical hyperplasia in breast tissue, although benign, is associated with a high risk of breast cancer. We investigated whether COX-2 overexpression in atypical hyperplasia is associated with the risk of subsequent breast cancer...
  16. pmc Molecular analysis of metaplastic breast carcinoma: high EGFR copy number via aneusomy
    Judith A Gilbert
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Mol Cancer Ther 7:944-51. 2008
    ....
  17. ncbi request reprint Loss of HSulf-1 expression enhances autocrine signaling mediated by amphiregulin in breast cancer
    Keishi Narita
    Department of Laboratory Medicine and Experimental Pathology, Mayo Clinic Cancer Center, Rochester, MN 55905, USA
    J Biol Chem 282:14413-20. 2007
    ..These data suggest a potential role of HSulf-1 down-regulation in mammary carcinogenesis...
  18. ncbi request reprint A two-gene expression ratio of homeobox 13 and interleukin-17B receptor for prediction of recurrence and survival in women receiving adjuvant tamoxifen
    Matthew P Goetz
    Department of Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Clin Cancer Res 12:2080-7. 2006
    ..In the adjuvant treatment of estrogen receptor (ER)-positive breast cancer, additional markers are needed to identify women at high risk for recurrence...
  19. ncbi request reprint Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
    Edward H Romond
    National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, USA
    N Engl J Med 353:1673-84. 2005
    ..We present the combined results of two trials that compared adjuvant chemotherapy with or without concurrent trastuzumab in women with surgically removed HER2-positive breast cancer...
  20. ncbi request reprint Centrosome amplification and the development of cancer
    Antonino B D'Assoro
    Tumor Biology Program, Mayo Clinic, Rochester, Minnesota, MN 55905, USA
    Oncogene 21:6146-53. 2002
  21. ncbi request reprint Amplified centrosomes in breast cancer: a potential indicator of tumor aggressiveness
    Antonino B D'Assoro
    Tumor Biology Program, Mayo Clinic Foundation, Rochester, MN 55905, USA
    Breast Cancer Res Treat 75:25-34. 2002
    ..Centrosome amplification is associated with mitotic spindle abnormalities in breast carcinomas and thus may contribute to genomic instability and the development of more aggressive phenotypes during tumor progression...
  22. ncbi request reprint The cytoskeleton differentially localizes the early growth response gene-1 protein in cancer and benign cells of the prostate
    Gloria R Mora
    Department of Urology Research, Mayo Clinic, Rochester, MN 55905, USA
    Mol Cancer Res 2:115-28. 2004
    ..Thus, we add the novel concept that microtubules regulate EGR-1 localization in benign prostate cells but not in malignant prostate cells...
  23. ncbi request reprint Utilizing Nottingham Prognostic Index in microarray gene expression profiling of breast carcinomas
    Dylan V Miller
    Department of Anatomic Pathology, Mayo Clinic, Rochester, MN 55906, USA
    Mod Pathol 17:756-64. 2004
    ..These data add support to the assertion that prognostic groups of breast carcinoma are reflected in distinguishable expression profiles of a limited set of genes...
  24. ncbi request reprint Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes
    Matthew P Goetz
    Department of Oncology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Clin Oncol 23:9312-8. 2005
    ..Polymorphisms in tamoxifen metabolizing genes affect the plasma concentration of tamoxifen metabolites, but their effect on clinical outcome is unknown...
  25. ncbi request reprint Centrosome amplification and the origin of chromosomal instability in breast cancer
    Jeffrey L Salisbury
    Tumor Biology Program, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Mammary Gland Biol Neoplasia 9:275-83. 2004
    ..This review focuses on the coordination of the centrosome, DNA, and cell cycles in normal cells and their deregulation resulting in centrosome amplification and chromosomal instability in the development and progression of breast cancer...
  26. pmc Estrogen mediates Aurora-A overexpression, centrosome amplification, chromosomal instability, and breast cancer in female ACI rats
    Jonathan J Li
    Hormonal Carcinogenesis Laboratory, Department of Pharmacology, Toxicology, and Experimental Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Proc Natl Acad Sci U S A 101:18123-8. 2004
    ..Thus, we report that estrogen is causally linked via estrogen receptor alpha to Aur-A overexpression, centrosome amplification, CIN, and aneuploidy leading to BC in susceptible mammary gland cells...
  27. ncbi request reprint Evaluation of a panel of tumor markers for molecular detection of circulating cancer cells in women with suspected breast cancer
    Monica M Reinholz
    Divisions of Experimental Pathology and Biostatistics, and Department of Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Clin Cancer Res 11:3722-32. 2005
    ..We examined the feasibility of using molecular characterization of circulating tumor cells as a method for early detection of breast cancer...
  28. ncbi request reprint Benign breast disease and the risk of breast cancer
    Lynn C Hartmann
    Division of Medical Oncology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    N Engl J Med 353:229-37. 2005
    ..Benign breast disease is an important risk factor for breast cancer. We studied a large group of women with benign breast disease to obtain reliable estimates of this risk...
  29. ncbi request reprint Folate receptor overexpression is associated with poor outcome in breast cancer
    Lynn C Hartmann
    Division of Medical Oncology, Mayo Clinic Cancer Center and Mayo Clinic College of Medicine, Rochester, MN
    Int J Cancer 121:938-42. 2007
    ..001. Our work requires validation in a larger cohort, but supports the possibility of using folate receptor-targeted approaches in the management of breast cancer...
  30. ncbi request reprint Short term cyclin D1 overexpression induces centrosome amplification, mitotic spindle abnormalities, and aneuploidy
    Christopher J Nelsen
    Division of Gastroenterology, Hennepin County Medical Center, Minneapolis, Minnesota 55415, USA
    J Biol Chem 280:768-76. 2005
    ..These results indicate that cyclin D1 can induce deregulation of the mitotic apparatus and aneuploidy, effects that could contribute to the role of this oncogene in malignancy...
  31. doi request reprint Expression of selected Aurora A kinase substrates in solely estrogen-induced ectopic uterine stem cell tumors in the Syrian hamster kidney
    Adrianne E Hontz
    Department of Pharmacology, University of Kansas University Medical Center, Kansas City, KS, USA
    Adv Exp Med Biol 617:411-8. 2008
    ..Collectively, these data indicate that over-expression of AurA/B is under estrogen control and that the deregulation of Aur kinase protein substrates is implicated in eliciting the alterations observed during oncogenesis...
  32. pmc Cisplatin abrogates the geldanamycin-induced heat shock response
    Andrea K McCollum
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Mol Cancer Ther 7:3256-64. 2008
    ..Clinical modulation of the HSF-1-mediated heat shock response may enhance the efficacy of Hsp90-directed therapy...
  33. ncbi request reprint Stratification of breast cancer risk in women with atypia: a Mayo cohort study
    Amy C Degnim
    Division of General Surgery, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Clin Oncol 25:2671-7. 2007
    ..Atypical hyperplasia is a well-recognized risk factor for breast cancer, conveying an approximately four-fold increased risk. Data regarding long-term absolute risk and factors for risk stratification are needed...