Research Topics
Species | W L LingleSummaryAffiliation: Mayo Clinic Country: USA Publications
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Publications
Centrosome amplification drives chromosomal instability in breast tumor developmentWilma L Lingle
Division of Experimental Pathology, Tumor Biology Program, Mayo Clinic, Rochester, MN 55905, USA
Proc Natl Acad Sci U S A 99:1978-83. 2002..These results further suggest that aspects of centrosome amplification may have clinical diagnostic and/or prognostic value and that the centrosome may be a potential target for cancer therapy...
Deregulation of the centrosome cycle and the origin of chromosomal instability in cancerWilma L Lingle
Mayo Clinic College of Medicine, Mayo Clinic Foundation, Mayo Clinic Cancer Center, Rochester, Minnesota 55905, USA
Adv Exp Med Biol 570:393-421. 2005..Centrosome amplification, therefore, can serve to exacerbate and/or generate genetic instabilities associated with cancers...- Altered centrosome structure is associated with abnormal mitoses in human breast tumorsW L Lingle
Tumor Biology Program, Mayo Foundation, Rochester, Minnesota 55905, USA
Am J Pathol 155:1941-51. 1999..Centrosome abnormalities may confer a mutator phenotype to tumors, occasionally yielding cells with a selective advantage that emerge and thrive, thus leading the tumor to a more aggressive state... - Microtubule nucleating capacity of centrosomes in tissue sectionsJ L Salisbury
Tumor Biology Program, Mayo Clinic, Rochester, Minnesota
J Histochem Cytochem 47:1265-74. 1999..These methods can be utilized to characterize MTOC activity in normal and diseased tissues and in particular tissues at different stages of development. (J Histochem Cytochem 47:1265-1273, 1999).. - Methods for the analysis of centrosome reproduction in cancer cellsW L Lingle
Experimental Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
Methods Cell Biol 67:325-36. 2001..This assay can also be used to characterize the microtubule nucleation capacity of normal tissues, during development and aging, and in disease states other than cancer where microtubule dynamics may play an important role... - Phase I trial of autologous hematopoietic SCT with escalating doses of topotecan combined with CY and carboplatin in patients with relapsed or persistent ovarian or primary peritoneal carcinomaM R Litzow
Division of Hematology, Mayo Clinic Cancer Center, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Bone Marrow Transplant 45:490-7. 2010..04). Topotecan can safely be dose escalated to 4.5 mg/m(2)/d in combination with CY, carboplatin and AHSCT. This trial is registered at ClinicalTrials.gov as NCT00652691... - The mitotic checkpoint protein hBUB3 and the mRNA export factor hRAE1 interact with GLE2p-binding sequence (GLEBS)-containing proteinsX Wang
Department of Pediatrics and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
J Biol Chem 276:26559-67. 2001..Our findings demonstrate that GLEBS motifs reside in mammalian nucleoporins and mitotic checkpoint proteins and apparently serve as specific binding sites for either BUB3, RAE1, or both... - Phosphorylation of centrin during the cell cycle and its role in centriole separation preceding centrosome duplicationW Lutz
Department of Biochemistry and Molecular Biology, Tumor Biology Program, Mayo Clinic Foundation, Rochester, Minnesota 55905, USA
J Biol Chem 276:20774-80. 2001..Taken together, these results suggest that centrin phosphorylation signals the separation of centrosomes at prophase and implicates centrin phosphorylation in centriole separation that normally precedes centrosome duplication... - Chronic exposure to lead chromate causes centrosome abnormalities and aneuploidy in human lung cellsAmie L Holmes
Wise Laboratory of Environmental and Genetic Toxicology, University of Southern Maine, Portland, Maine, USA
Cancer Res 66:4041-8. 2006..These data suggest that one possible mechanism for lead chromate-induced carcinogenesis is through centrosome dysfunction, leading to the induction of aneuploidy... - The granulin-epithelin precursor is a steroid-regulated growth factor in endometrial cancerMonica Brown Jones
Mayo Clinic, Gynecologic Surgery, Rochester, Minnesota 55905, USA
J Soc Gynecol Investig 13:304-11. 2006..Once we established the co-expression of GEP with the estrogen receptor we examined the potential estrogen regulation of GEP expression, as well as the functional significance of GEP expression in vitro... - HER2 testing by local, central, and reference laboratories in specimens from the North Central Cancer Treatment Group N9831 intergroup adjuvant trialEdith A Perez
Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224, USA
J Clin Oncol 24:3032-8. 2006..To evaluate concordance between local and central laboratory HER2 testing results in patients from the North Central Cancer Treatment Group (NCCTG) N9831 adjuvant trial of trastuzumab... - The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifenMatthew P Goetz
Department of Oncology, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, MN, 55905, USA
Breast Cancer Res Treat 101:113-21. 2007.... - Cytochrome P450 2D6 and homeobox 13/interleukin-17B receptor: combining inherited and tumor gene markers for prediction of tamoxifen resistanceMatthew P Goetz
Department of Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Clin Cancer Res 14:5864-8. 2008..We sought to determine the combined effect of inherited (CYP2D6) and somatic (HOXB13/IL17BR) gene variation in tamoxifen-treated breast cancer... - Aurora a and B overexpression and centrosome amplification in early estrogen-induced tumor foci in the Syrian hamster kidney: implications for chromosomal instability, aneuploidy, and neoplasiaAdrianne E Hontz
Hormonal Carcinogenesis Laboratory, Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, USA
Cancer Res 67:2957-63. 2007.... 
Association between cyclooxygenase-2 expression in atypical hyperplasia and risk of breast cancerDaniel W Visscher
Department of Surgical Pathology, University of Michigan, Ann Arbor, MI, USA
J Natl Cancer Inst 100:421-7. 2008..Atypical hyperplasia in breast tissue, although benign, is associated with a high risk of breast cancer. We investigated whether COX-2 overexpression in atypical hyperplasia is associated with the risk of subsequent breast cancer...- Molecular analysis of metaplastic breast carcinoma: high EGFR copy number via aneusomyJudith A Gilbert
Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Mol Cancer Ther 7:944-51. 2008.... - Loss of HSulf-1 expression enhances autocrine signaling mediated by amphiregulin in breast cancerKeishi Narita
Department of Laboratory Medicine and Experimental Pathology, Mayo Clinic Cancer Center, Rochester, MN 55905, USA
J Biol Chem 282:14413-20. 2007..These data suggest a potential role of HSulf-1 down-regulation in mammary carcinogenesis... - A two-gene expression ratio of homeobox 13 and interleukin-17B receptor for prediction of recurrence and survival in women receiving adjuvant tamoxifenMatthew P Goetz
Department of Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
Clin Cancer Res 12:2080-7. 2006..In the adjuvant treatment of estrogen receptor (ER)-positive breast cancer, additional markers are needed to identify women at high risk for recurrence... - Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancerEdward H Romond
National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, USA
N Engl J Med 353:1673-84. 2005..CONCLUSIONS: Trastuzumab combined with paclitaxel after doxorubicin and cyclophosphamide improves outcomes among women with surgically removed HER2-positive breast cancer. (ClinicalTrials.gov numbers, NCT00004067 and NCT00005970.).. - Centrosome amplification and the development of cancerWilma L Lingle
Tumor Biology Program, Mayo Clinic, Rochester, Minnesota, MN 55905, USA
Oncogene 21:6146-53. 2002 - Amplified centrosomes in breast cancer: a potential indicator of tumor aggressivenessSusan L Barrett
Tumor Biology Program, Mayo Clinic Foundation, Rochester, MN 55905, USA
Breast Cancer Res Treat 75:25-34. 2002..Centrosome amplification is associated with mitotic spindle abnormalities in breast carcinomas and thus may contribute to genomic instability and the development of more aggressive phenotypes during tumor progression... - The cytoskeleton differentially localizes the early growth response gene-1 protein in cancer and benign cells of the prostateGloria R Mora
Department of Urology Research, Mayo Clinic, Rochester, MN 55905, USA
Mol Cancer Res 2:115-28. 2004..Thus, we add the novel concept that microtubules regulate EGR-1 localization in benign prostate cells but not in malignant prostate cells... - Utilizing Nottingham Prognostic Index in microarray gene expression profiling of breast carcinomasDylan V Miller
Department of Anatomic Pathology, Mayo Clinic, Rochester, MN 55906, USA
Mod Pathol 17:756-64. 2004..These data add support to the assertion that prognostic groups of breast carcinoma are reflected in distinguishable expression profiles of a limited set of genes... - Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashesMatthew P Goetz
Department of Oncology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
J Clin Oncol 23:9312-8. 2005..Polymorphisms in tamoxifen metabolizing genes affect the plasma concentration of tamoxifen metabolites, but their effect on clinical outcome is unknown... - Centrosome amplification and the origin of chromosomal instability in breast cancerJeffrey L Salisbury
Tumor Biology Program, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
J Mammary Gland Biol Neoplasia 9:275-83. 2004..This review focuses on the coordination of the centrosome, DNA, and cell cycles in normal cells and their deregulation resulting in centrosome amplification and chromosomal instability in the development and progression of breast cancer... - Estrogen mediates Aurora-A overexpression, centrosome amplification, chromosomal instability, and breast cancer in female ACI ratsJonathan J Li
Hormonal Carcinogenesis Laboratory, Department of Pharmacology, Toxicology, and Experimental Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
Proc Natl Acad Sci U S A 101:18123-8. 2004..Thus, we report that estrogen is causally linked via estrogen receptor alpha to Aur-A overexpression, centrosome amplification, CIN, and aneuploidy leading to BC in susceptible mammary gland cells... - Evaluation of a panel of tumor markers for molecular detection of circulating cancer cells in women with suspected breast cancerMonica M Reinholz
Divisions of Experimental Pathology and Biostatistics, and Department of Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
Clin Cancer Res 11:3722-32. 2005..We examined the feasibility of using molecular characterization of circulating tumor cells as a method for early detection of breast cancer... - Benign breast disease and the risk of breast cancerLynn C Hartmann
Division of Medical Oncology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
N Engl J Med 353:229-37. 2005..CONCLUSIONS: Risk factors for breast cancer after the diagnosis of benign breast disease include the histologic classification of a benign breast lesion and a family history of breast cancer... - Folate receptor overexpression is associated with poor outcome in breast cancerLynn C Hartmann
Division of Medical Oncology, Mayo Clinic Cancer Center and Mayo Clinic College of Medicine, Rochester, MN
Int J Cancer 121:938-42. 2007..001. Our work requires validation in a larger cohort, but supports the possibility of using folate receptor-targeted approaches in the management of breast cancer... - Short term cyclin D1 overexpression induces centrosome amplification, mitotic spindle abnormalities, and aneuploidyChristopher J Nelsen
Division of Gastroenterology, Hennepin County Medical Center, Minneapolis, Minnesota 55415, USA
J Biol Chem 280:768-76. 2005..These results indicate that cyclin D1 can induce deregulation of the mitotic apparatus and aneuploidy, effects that could contribute to the role of this oncogene in malignancy... - Expression of selected Aurora A kinase substrates in solely estrogen-induced ectopic uterine stem cell tumors in the Syrian hamster kidneyAdrianne E Hontz
Department of Pharmacology, University of Kansas University Medical Center, Kansas City, KS, USA
Adv Exp Med Biol 617:411-8. 2008..Collectively, these data indicate that over-expression of AurA/B is under estrogen control and that the deregulation of Aur kinase protein substrates is implicated in eliciting the alterations observed during oncogenesis... - Cisplatin abrogates the geldanamycin-induced heat shock responseAndrea K McCollum
Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Mol Cancer Ther 7:3256-64. 2008..Clinical modulation of the HSF-1-mediated heat shock response may enhance the efficacy of Hsp90-directed therapy... - Stratification of breast cancer risk in women with atypia: a Mayo cohort studyAmy C Degnim
Division of General Surgery, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
J Clin Oncol 25:2671-7. 2007..Atypical hyperplasia is a well-recognized risk factor for breast cancer, conveying an approximately four-fold increased risk. Data regarding long-term absolute risk and factors for risk stratification are needed...