Paul Limburg

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Insulin, glucose, insulin resistance, and incident colorectal cancer in male smokers
    Paul J Limburg
    Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Clin Gastroenterol Hepatol 4:1514-21. 2006
  2. pmc Randomized phase II trial of sulindac for lung cancer chemoprevention
    Paul J Limburg
    Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States
    Lung Cancer 79:254-61. 2013
  3. pmc Postmenopausal hormone therapy and colorectal cancer risk by molecularly defined subtypes among older women
    David Limsui
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA
    Gut 61:1299-305. 2012
  4. pmc Postmenopausal hormone therapy and colorectal cancer risk in relation to somatic KRAS mutation status among older women
    Paul J Limburg
    Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 21:681-4. 2012
  5. ncbi request reprint Helicobacter pylori seropositivity and subsite-specific gastric cancer risks in Linxian, China
    P Limburg
    Cancer Prevention Studies Branch, Division of Clinical Sciences, National Cancer Institute, Bethesda, MD, USA
    J Natl Cancer Inst 93:226-33. 2001
  6. pmc Prospective evaluation of trans-fatty acid intake and colorectal cancer risk in the Iowa Women's Health Study
    Paul J Limburg
    Mayo Clinic Cancer Center, Rochester, MN 55905, USA
    Int J Cancer 123:2717-9. 2008
  7. ncbi request reprint Randomized, placebo-controlled, esophageal squamous cell cancer chemoprevention trial of selenomethionine and celecoxib
    Paul J Limburg
    Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Gastroenterology 129:863-73. 2005
  8. ncbi request reprint Diabetes mellitus and subsite-specific colorectal cancer risks in the Iowa Women's Health Study
    Paul J Limburg
    Division of Epidemiology, University of Minnesota, 1300 South Second Street, Suite 300, Minneapolis, MN 55454, USA
    Cancer Epidemiol Biomarkers Prev 14:133-7. 2005
  9. pmc Randomized phase II trial of sulindac, atorvastatin, and prebiotic dietary fiber for colorectal cancer chemoprevention
    Paul J Limburg
    Mayo Clinic Rochester, Rochester, MN 55905, USA
    Cancer Prev Res (Phila) 4:259-69. 2011
  10. pmc Prevalence of alterations in DNA mismatch repair genes in patients with young-onset colorectal cancer
    Paul J Limburg
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA
    Clin Gastroenterol Hepatol 9:497-502. 2011

Research Grants

Detail Information

Publications50

  1. pmc Insulin, glucose, insulin resistance, and incident colorectal cancer in male smokers
    Paul J Limburg
    Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Clin Gastroenterol Hepatol 4:1514-21. 2006
    ..To date, few studies have directly examined serum insulin as an indicator of CRC risk, and none have reported associations on the basis of HOMA-IR...
  2. pmc Randomized phase II trial of sulindac for lung cancer chemoprevention
    Paul J Limburg
    Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States
    Lung Cancer 79:254-61. 2013
    ..We conducted a randomized, phase II chemoprevention trial involving current or former cigarette smokers (≥30 pack-years) utilizing the multi-center, inter-disciplinary infrastructure of the Cancer Prevention Network (CPN)...
  3. pmc Postmenopausal hormone therapy and colorectal cancer risk by molecularly defined subtypes among older women
    David Limsui
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA
    Gut 61:1299-305. 2012
    ..Postmenopausal hormone (PMH) therapy may reduce colorectal cancer (CRC) risk, but existing data are inconclusive...
  4. pmc Postmenopausal hormone therapy and colorectal cancer risk in relation to somatic KRAS mutation status among older women
    Paul J Limburg
    Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 21:681-4. 2012
    ....
  5. ncbi request reprint Helicobacter pylori seropositivity and subsite-specific gastric cancer risks in Linxian, China
    P Limburg
    Cancer Prevention Studies Branch, Division of Clinical Sciences, National Cancer Institute, Bethesda, MD, USA
    J Natl Cancer Inst 93:226-33. 2001
    ..Consequently, we designed this prospective, nested case-control study to further explore the subsite-specific gastric cancer risks associated with H. pylori seropositivity (a surrogate marker for persistent exposure)...
  6. pmc Prospective evaluation of trans-fatty acid intake and colorectal cancer risk in the Iowa Women's Health Study
    Paul J Limburg
    Mayo Clinic Cancer Center, Rochester, MN 55905, USA
    Int J Cancer 123:2717-9. 2008
    ..Multivariable adjustment yielded slightly attenuated risk estimates, but the observed associations were not meaningfully altered. Given these findings, tFA intake does not appear to be a major CRC risk factor, at least among older women...
  7. ncbi request reprint Randomized, placebo-controlled, esophageal squamous cell cancer chemoprevention trial of selenomethionine and celecoxib
    Paul J Limburg
    Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Gastroenterology 129:863-73. 2005
    ..Squamous dysplasia, the accepted histological precursor for esophageal squamous cell carcinoma, represents a potentially modifiable intermediate end point for chemoprevention trials in high-risk populations...
  8. ncbi request reprint Diabetes mellitus and subsite-specific colorectal cancer risks in the Iowa Women's Health Study
    Paul J Limburg
    Division of Epidemiology, University of Minnesota, 1300 South Second Street, Suite 300, Minneapolis, MN 55454, USA
    Cancer Epidemiol Biomarkers Prev 14:133-7. 2005
    ....
  9. pmc Randomized phase II trial of sulindac, atorvastatin, and prebiotic dietary fiber for colorectal cancer chemoprevention
    Paul J Limburg
    Mayo Clinic Rochester, Rochester, MN 55905, USA
    Cancer Prev Res (Phila) 4:259-69. 2011
    ....
  10. pmc Prevalence of alterations in DNA mismatch repair genes in patients with young-onset colorectal cancer
    Paul J Limburg
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA
    Clin Gastroenterol Hepatol 9:497-502. 2011
    ..We examined the prevalence of mutations in MLH1, MSH2, and MSH6 in a population-based sample of patients with young-onset (age <50 years) colorectal cancer (CRC)...
  11. pmc Alcohol intake and colorectal cancer risk by molecularly defined subtypes in a prospective study of older women
    Anthony A Razzak
    Department of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Cancer Prev Res (Phila) 4:2035-43. 2011
    ..05 for each comparison). These data do not support an adverse effect from alcohol intake on CRC risk, overall or by specific molecularly defined subtypes, among older women...
  12. ncbi request reprint Insulin, glucose, insulin resistance, and pancreatic cancer in male smokers
    Rachael Z Stolzenberg-Solomon
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, MD 20852, USA
    JAMA 294:2872-8. 2005
    ..Obesity, diabetes mellitus, and glucose intolerance have been associated with increased pancreatic cancer risk; however, prediagnostic serum insulin concentration has not been evaluated as a predictor of this malignancy...
  13. ncbi request reprint A prospective study of anthropometric and clinical measurements associated with insulin resistance syndrome and colorectal cancer in male smokers
    Katherine Bowers
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
    Am J Epidemiol 164:652-64. 2006
    ..58, 95% CI: 1.18, 2.10), but not rectal cancer. These results support the hypothesis that the significant association observed between IRS-defining metabolic abnormalities and colorectal cancer is determined primarily by adiposity...
  14. ncbi request reprint Insulin-like growth factor (IGF)-1, IGF-binding protein-3, and pancreatic cancer in male smokers
    Rachael Z Stolzenberg-Solomon
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Cancer Epidemiol Biomarkers Prev 13:438-44. 2004
    ..Our results do not support the hypothesis that serum IGF-1 and IGFBP-3 concentrations are associated with pancreatic cancer risk among male smokers. Further studies are necessary to evaluate these associations in other populations...
  15. ncbi request reprint Nonsteroidal anti-inflammatory drugs and subsite-specific colorectal cancer incidence in the Iowa women's health study
    Amit Mahipal
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 South Second Street, Minneapolis, MN 55454, USA
    Cancer Epidemiol Biomarkers Prev 15:1785-90. 2006
    ....
  16. pmc Serum insulin, glucose, indices of insulin resistance, and risk of prostate cancer
    Demetrius Albanes
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rm 3044, Bethesda, MD 20892 7242, USA
    J Natl Cancer Inst 101:1272-9. 2009
    ..The mitogenic and growth-stimulatory effects of insulin-like growth factors appear to play a role in prostate carcinogenesis, yet any direct association of circulating insulin levels and risk of prostate cancer remains unclear...
  17. pmc Cigarette smoking and colorectal cancer risk by molecularly defined subtypes
    David Limsui
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Natl Cancer Inst 102:1012-22. 2010
    ..Because colorectal carcinogenesis is a heterogeneous process, we investigated whether cigarette smoking is differentially associated with molecularly defined subtypes of colorectal cancer...
  18. pmc Alpha-1-antitrypsin deficiency and smoking as risk factors for mismatch repair deficient colorectal cancer: a study from the colon cancer family registry
    Noralane M Lindor
    Department of Medical Genetics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Mol Genet Metab 99:157-9. 2010
    ..No difference in frequency of A1AT deficiency alleles was found between cases and controls, irrespective of the MSI subtype...
  19. ncbi request reprint Can complementary and alternative medicine clinical cancer research be successfully accomplished? The Mayo Clinic-North Central Cancer Treatment Group experience
    Debra L Barton
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Soc Integr Oncol 4:143-52. 2006
    ..Well-designed and adequately powered studies can be implemented, and large numbers of patients can be accrued. The resulting research evaluations can be published in peer-reviewed medical journals...
  20. ncbi request reprint Prospective study of bacteremia and complications With EUS FNA of rectal and perirectal lesions
    Michael J Levy
    Division of Gastroenterology and Hepatology, Mayo Clinic Foundation, Rochester, Minnesota 55905, USA
    Clin Gastroenterol Hepatol 5:684-9. 2007
    ..As a result, antibiotics are not recommended for prophylaxis against endocarditis. Our aim was to prospectively evaluate the risk of bacteremia and other infectious complications in patients undergoing EUS FNA of lower GI tract lesions...
  21. ncbi request reprint Cigarette smoking and colorectal cancer: long-term, subsite-specific risks in a cohort study of postmenopausal women
    Paul J Limburg
    Divisions of Gastroenterology and Hepatology and Epidemiology, Mayo Clinic Cancer Center, Rochester, Minnesota, USA
    Clin Gastroenterol Hepatol 1:202-10. 2003
    ..However, long-term CRC risk estimates among female smokers remain limited and inconsistent. The goal of this prospective study was to assess cigarette smoking and CRC risk, overall and by anatomic subsite, among postmenopausal women...
  22. ncbi request reprint Association of aspirin and nonaspirin nonsteroidal anti-inflammatory drugs with cancer incidence and mortality
    Aditya Bardia
    Department of Internal Medicine, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    J Natl Cancer Inst 99:881-9. 2007
    ..We evaluated associations between aspirin and nonaspirin NSAID use with cancer incidence and mortality stratified by smoking history in the Iowa Women's Health Study, a prospective cohort of postmenopausal women...
  23. doi request reprint Young-onset colorectal cancer in patients with no known genetic predisposition: can we increase early recognition and improve outcome?
    Eric J Dozois
    Division of Colon and Rectal Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Medicine (Baltimore) 87:259-63. 2008
    ..Our findings should promote increased awareness and the aggressive pursuit of symptoms in otherwise young, low-risk patients, as these symptoms may represent an underlying colorectal malignancy...
  24. pmc Parent of origin effects on age at colorectal cancer diagnosis
    Noralane M Lindor
    Department of Medical Genetics, Mayo Clinic, Rochester, MN, USA
    Int J Cancer 127:361-6. 2010
    ....
  25. ncbi request reprint Gene expression differences in normal esophageal mucosa associated with regression and progression of mild and moderate squamous dysplasia in a high-risk Chinese population
    Nina Joshi
    Genetics Branch, Center for Cancer Research, National Cancer Institute NIH, EPS, 6120 Executive Boulevard, Bethesda, MD 20892, USA
    Cancer Res 66:6851-60. 2006
    ..These data suggest that local and systemic immune responses may influence the natural history of esophageal squamous dysplasia...
  26. ncbi request reprint Prepregnancy exposure to cigarette smoking and subsequent risk of postmenopausal breast cancer
    Janet E Olson
    Division of Epidemiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Mayo Clin Proc 80:1423-8. 2005
    ..To examine the association of cigarette smoking before first pregnancy with risk of postmenopausal breast cancer in a large population-based cohort...
  27. pmc Coffee phenolic phytochemicals suppress colon cancer metastasis by targeting MEK and TOPK
    Nam Joo Kang
    The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Carcinogenesis 32:921-8. 2011
    ..These results suggest that coffee and CaA target MEK1 and TOPK to suppress colon cancer metastasis and neoplastic cell transformation...
  28. ncbi request reprint Incidence of colorectal cancer in relation to glycemic index and load in a cohort of women
    Mary McCarl
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Suite 300, 1300 South Second Street, Minneapolis, MN 55454 1015, USA
    Cancer Epidemiol Biomarkers Prev 15:892-6. 2006
    ..Elevated circulating insulin concentrations can increase insulin-like growth factor-1, and both of these hormones may have growth-promoting effects within the colorectum...
  29. ncbi request reprint Epidemiology and prevention of colorectal cancer
    Ernest T Hawk
    Gastrointestinal and Other Cancers Research Group, National Cancer Institute, Division of Cancer Prevention, EPN, Suite 2141, 6130 Executive Boulevard, Bethesda, MD 20892 7317, USA
    Surg Clin North Am 82:905-41. 2002
    ..The challenges and rewards of participation in chemoprevention research--both as patients and health care providers-have never been greater...
  30. pmc Serum cytokine analysis in a positive chemoprevention trial: selenium, interleukin-2, and an association with squamous preneoplastic disease
    Mark J Roth
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7232, USA
    Cancer Prev Res (Phila) 3:810-7. 2010
    ..The favorable effect of selenomethionine on esophageal dysplasia in the original trial may have been mediated in part by its effect in reducing the levels of IL-2...
  31. ncbi request reprint Clinically confirmed type 2 diabetes mellitus and colorectal cancer risk: a population-based, retrospective cohort study
    Paul J Limburg
    Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Am J Gastroenterol 101:1872-9. 2006
    ..However, existing data are inconsistent. We investigated CRC risks, overall and by anatomic subsite, within a population-based inception cohort of clinically confirmed type 2 DM subjects...
  32. ncbi request reprint Antibacterial properties and toxicity of Atuna racemosa extract depend on kernel maturity
    Eric J Buenz
    Complementary and Integrative Medicine Program, Mayo Clinic College of Medicine, Rochester, MN, USA
    J Ethnopharmacol 111:592-7. 2007
    ..These findings have implications for the use of this natural product as an antibiotic and chemotherapeutic agent...
  33. ncbi request reprint Helicobacter pylori seropositivity and colorectal cancer risk: a prospective study of male smokers
    Paul J Limburg
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer Epidemiol Biomarkers Prev 11:1095-9. 2002
    ..91 (0.53-1.55), respectively. Stratification by colorectal cancer subsite yielded similarly unremarkable results. On the basis of these data, H. pylori carriage does not appear to be an important risk factor for colorectal adenocarcinoma...
  34. ncbi request reprint Assessing attitudes toward laxative preparation in colorectal cancer screening and effects on future testing: potential receptivity to computed tomographic colonography
    Timothy J Beebe
    Department of Health Sciences Research, College of Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Mayo Clin Proc 82:666-71. 2007
    ..The overall response rate was 49%. Analysis focused on the 759 respondents who were 50 years or older...
  35. ncbi request reprint Colorectal cancer chemoprevention
    Paul J Limburg
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Chin J Dig Dis 5:7-11. 2004
  36. ncbi request reprint Colorectal cancer prognosis among patients with inflammatory bowel disease
    Thierry Delaunoit
    Department of Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Clin Gastroenterol Hepatol 4:335-42. 2006
    ..The objectives of this study were to describe the clinicopathologic features of IBD-associated CRC and to compare survival rates between patients with IBD-associated CRC and patients with sporadic CRC...
  37. pmc Body size and incident colorectal cancer: a prospective study of older women
    Amy S Oxentenko
    College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Cancer Prev Res (Phila) 3:1608-20. 2010
    ..e., early adulthood versus later adulthood) might also be informative, particularly with respect to defining subsite-specific pathways of colorectal carcinogenesis...
  38. doi request reprint Efficacy of antioxidant supplementation in reducing primary cancer incidence and mortality: systematic review and meta-analysis
    Aditya Bardia
    Department of Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Mayo Clin Proc 83:23-34. 2008
    ..To estimate the association between antioxidant use and primary cancer incidence and mortality and to evaluate these effects across specific antioxidant compounds, target organs, and participant subgroups...
  39. ncbi request reprint Prospective evaluation of fecal calprotectin as a screening biomarker for colorectal neoplasia
    Paul J Limburg
    Division of Gastroenterology and Hepatology and Department of Biostatistics, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Gastroenterol 98:2299-305. 2003
    ..Fecal calprotectin was directly compared to fecal hemoglobin (Hb) and colonoscopy as the existing criterion standards for stool screening and structural evaluation, respectively...
  40. ncbi request reprint Small bowel adenocarcinoma: a rare but aggressive disease
    Thierry Delaunoit
    Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA
    Clin Colorectal Cancer 4:241-8; discussion 249-51. 2004
    ..We reviewed the clinical aspects of this rare but aggressive disease, focusing on new diagnostic procedures as well as on recent advances in their therapeutic management...
  41. ncbi request reprint Pathogenesis and risk factors of small bowel adenocarcinoma: a colorectal cancer sibling?
    Thierry Delaunoit
    Department of Oncology, Molecular Medicine Program, and Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA
    Am J Gastroenterol 100:703-10. 2005
    ..Better understanding of sporadic and hereditary genetic pathways potentially involved will undoubtedly lead to better prevention and therapeutic management of this rare but aggressive disease...
  42. ncbi request reprint Effect of slice thickness and primary 2D versus 3D virtual dissection on colorectal lesion detection at CT colonography in 452 asymptomatic adults
    C Daniel Johnson
    Department of Radiology, Mayo Clinic, 200 First St, SW, Rochester, MN 55905, USA
    AJR Am J Roentgenol 189:672-80. 2007
    ..The objective of our study was to compare the performance of primary 3D search using 360 degree virtual dissection with primary 2D search using a 2.5- versus a 1.25-mm slice thickness...
  43. ncbi request reprint Colorectal cancer screening education, prioritization, and self-perceived preparedness among primary care residents: data from a national survey
    Amy S Oxentenko
    Mayo Clinic College of Medicine, Rochester, MN, USA
    J Cancer Educ 22:208-18. 2007
    ....
  44. doi request reprint Functional and clinical significance of variants localized to 8q24 in colon cancer
    Mine S Cicek
    Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street Southwest, 920 Hilton Building, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 18:2492-500. 2009
    ..Finally, these risk alleles do not seem to be associated with survival...
  45. ncbi request reprint Colorectal cancer screening perceptions and practices: results from a national survey of gastroenterology, surgery and radiology trainees
    Amy S Oxentenko
    Mayo Clinic College of Medicine, Rochester, MN, USA
    J Cancer Educ 22:219-26. 2007
    ....
  46. ncbi request reprint Selenomethionine treatment does not alter gene expression in normal squamous esophageal mucosa in a high-risk Chinese population
    Nina Joshi
    Amgen, 1201 Amgen Court West, AW1 J 4144, Seattle, WA 98119 3105, USA
    Cancer Epidemiol Biomarkers Prev 15:1046-7. 2006
    ....
  47. ncbi request reprint Accuracy of colorectal polyp self-reports: findings from the colon cancer family registry
    Lisa Madlensky
    Moores UCSD Cancer Center, 3855 Health Sciences Drive, MC0901, La Jolla, CA 92093 0901, USA
    Cancer Epidemiol Biomarkers Prev 16:1898-901. 2007
    ..However, it is not known how accurately patients are able to self-report the presence or absence of adenomas following colonoscopy...
  48. pmc Accuracy of CT colonography for detection of large adenomas and cancers
    C Daniel Johnson
    Mayo Clinic Arizona, Scottsdale, AZ, USA
    N Engl J Med 359:1207-17. 2008
    ..Computed tomographic (CT) colonography is a noninvasive option in screening for colorectal cancer. However, its accuracy as a screening tool in asymptomatic adults has not been well defined...
  49. ncbi request reprint Can selenium supplementation prevent colorectal cancer?
    Steven B Ingle
    Gastroenterology 131:1646-7. 2006
  50. ncbi request reprint Second primary colorectal cancer: the consequence of management failure at several potential levels
    Paul J Limburg
    Ann Intern Med 136:335-7. 2002

Research Grants7

  1. Insulin, the IGF Axis, and Colorectal Neoplasia
    Paul Limburg; Fiscal Year: 2005
    ..Following achievement of these goals, I am confident that I will be ready to continue my career as a successful independent investigator committed to academic research. ..
  2. Molecular Epidemiology of Colorectal Cancer Subtypes
    Paul Limburg; Fiscal Year: 2007
    ....
  3. Molecular Epidemiology of Colorectal Cancer Subtypes
    Paul J Limburg; Fiscal Year: 2010
    ....