Research Topics
Species | Paul LimburgSummaryAffiliation: Mayo Clinic Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Insulin, glucose, insulin resistance, and incident colorectal cancer in male smokersPaul J Limburg
Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Clin Gastroenterol Hepatol 4:1514-21. 2006..To date, few studies have directly examined serum insulin as an indicator of CRC risk, and none have reported associations on the basis of HOMA-IR...- Randomized phase II trial of sulindac for lung cancer chemopreventionPaul J Limburg
Mayo Clinic, Rochester, MN, United States Electronic address
Lung Cancer 79:254-61. 2013..We conducted a randomized, phase II chemoprevention trial involving current or former cigarette smokers (≥30 pack-years) utilizing the multi-center, inter-disciplinary infrastructure of the Cancer Prevention Network (CPN)... - Postmenopausal hormone therapy and colorectal cancer risk by molecularly defined subtypes among older womenDavid Limsui
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA
Gut 61:1299-305. 2012..Postmenopausal hormone (PMH) therapy may reduce colorectal cancer (CRC) risk, but existing data are inconclusive... - Postmenopausal hormone therapy and colorectal cancer risk in relation to somatic KRAS mutation status among older womenPaul J Limburg
Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Cancer Epidemiol Biomarkers Prev 21:681-4. 2012.... 
Helicobacter pylori seropositivity and subsite-specific gastric cancer risks in Linxian, ChinaP Limburg
Cancer Prevention Studies Branch, Division of Clinical Sciences, National Cancer Institute, Bethesda, MD, USA
J Natl Cancer Inst 93:226-33. 2001..Consequently, we designed this prospective, nested case-control study to further explore the subsite-specific gastric cancer risks associated with H. pylori seropositivity (a surrogate marker for persistent exposure)...- Prospective evaluation of trans-fatty acid intake and colorectal cancer risk in the Iowa Women's Health StudyPaul J Limburg
Mayo Clinic Cancer Center, Rochester, MN 55905, USA
Int J Cancer 123:2717-9. 2008..Multivariable adjustment yielded slightly attenuated risk estimates, but the observed associations were not meaningfully altered. Given these findings, tFA intake does not appear to be a major CRC risk factor, at least among older women... - Randomized, placebo-controlled, esophageal squamous cell cancer chemoprevention trial of selenomethionine and celecoxibPaul J Limburg
Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Gastroenterology 129:863-73. 2005..Squamous dysplasia, the accepted histological precursor for esophageal squamous cell carcinoma, represents a potentially modifiable intermediate end point for chemoprevention trials in high-risk populations... - Diabetes mellitus and subsite-specific colorectal cancer risks in the Iowa Women's Health StudyPaul J Limburg
Division of Epidemiology, University of Minnesota, 1300 South Second Street, Suite 300, Minneapolis, MN 55454, USA
Cancer Epidemiol Biomarkers Prev 14:133-7. 2005.... - Randomized phase II trial of sulindac, atorvastatin, and prebiotic dietary fiber for colorectal cancer chemopreventionPaul J Limburg
Mayo Clinic Rochester, Rochester, MN 55905, USA
Cancer Prev Res (Phila) 4:259-69. 2011.... - Prevalence of alterations in DNA mismatch repair genes in patients with young-onset colorectal cancerPaul J Limburg
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA
Clin Gastroenterol Hepatol 9:497-502. 2011..We examined the prevalence of mutations in MLH1, MSH2, and MSH6 in a population-based sample of patients with young-onset (age <50 years) colorectal cancer (CRC)... - Alcohol intake and colorectal cancer risk by molecularly defined subtypes in a prospective study of older womenAnthony A Razzak
Department of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Cancer Prev Res (Phila) 4:2035-43. 2011..05 for each comparison). These data do not support an adverse effect from alcohol intake on CRC risk, overall or by specific molecularly defined subtypes, among older women... - Insulin, glucose, insulin resistance, and pancreatic cancer in male smokersRachael Z Stolzenberg-Solomon
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, MD 20852, USA
JAMA 294:2872-8. 2005..Obesity, diabetes mellitus, and glucose intolerance have been associated with increased pancreatic cancer risk; however, prediagnostic serum insulin concentration has not been evaluated as a predictor of this malignancy... - A prospective study of anthropometric and clinical measurements associated with insulin resistance syndrome and colorectal cancer in male smokersKatherine Bowers
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
Am J Epidemiol 164:652-64. 2006..58, 95% CI: 1.18, 2.10), but not rectal cancer. These results support the hypothesis that the significant association observed between IRS-defining metabolic abnormalities and colorectal cancer is determined primarily by adiposity... - Insulin-like growth factor (IGF)-1, IGF-binding protein-3, and pancreatic cancer in male smokersRachael Z Stolzenberg-Solomon
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
Cancer Epidemiol Biomarkers Prev 13:438-44. 2004..Our results do not support the hypothesis that serum IGF-1 and IGFBP-3 concentrations are associated with pancreatic cancer risk among male smokers. Further studies are necessary to evaluate these associations in other populations... - Nonsteroidal anti-inflammatory drugs and subsite-specific colorectal cancer incidence in the Iowa women's health studyAmit Mahipal
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 South Second Street, Minneapolis, MN 55454, USA
Cancer Epidemiol Biomarkers Prev 15:1785-90. 2006..DISCUSSION: Our study is consistent with a limited number of prior reports that have observed stronger associations between NSAID use and proximal versus distal colorectal cancer... - Serum insulin, glucose, indices of insulin resistance, and risk of prostate cancerDemetrius Albanes
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rm 3044, Bethesda, MD 20892 7242, USA
J Natl Cancer Inst 101:1272-9. 2009..The mitogenic and growth-stimulatory effects of insulin-like growth factors appear to play a role in prostate carcinogenesis, yet any direct association of circulating insulin levels and risk of prostate cancer remains unclear... - Cigarette smoking and colorectal cancer risk by molecularly defined subtypesDavid Limsui
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
J Natl Cancer Inst 102:1012-22. 2010..Because colorectal carcinogenesis is a heterogeneous process, we investigated whether cigarette smoking is differentially associated with molecularly defined subtypes of colorectal cancer... - Alpha-1-antitrypsin deficiency and smoking as risk factors for mismatch repair deficient colorectal cancer: a study from the colon cancer family registryNoralane M Lindor
Department of Medical Genetics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Mol Genet Metab 99:157-9. 2010..No difference in frequency of A1AT deficiency alleles was found between cases and controls, irrespective of the MSI subtype... - Can complementary and alternative medicine clinical cancer research be successfully accomplished? The Mayo Clinic-North Central Cancer Treatment Group experienceDebra L Barton
Mayo Clinic College of Medicine, Rochester, MN 55905, USA
J Soc Integr Oncol 4:143-52. 2006..Well-designed and adequately powered studies can be implemented, and large numbers of patients can be accrued. The resulting research evaluations can be published in peer-reviewed medical journals... - Prospective study of bacteremia and complications With EUS FNA of rectal and perirectal lesionsMichael J Levy
Division of Gastroenterology and Hepatology, Mayo Clinic Foundation, Rochester, Minnesota 55905, USA
Clin Gastroenterol Hepatol 5:684-9. 2007..As a result, antibiotics are not recommended for prophylaxis against endocarditis. Our aim was to prospectively evaluate the risk of bacteremia and other infectious complications in patients undergoing EUS FNA of lower GI tract lesions... - Cigarette smoking and colorectal cancer: long-term, subsite-specific risks in a cohort study of postmenopausal womenPaul J Limburg
Divisions of Gastroenterology and Hepatology and Epidemiology, Mayo Clinic Cancer Center, Rochester, Minnesota, USA
Clin Gastroenterol Hepatol 1:202-10. 2003..These data support a potential subsite-specific role for cigarette smoking in colorectal carcinogenesis, at least among women. Based on emerging data, an epigenetic pathway for smoking-induced CRC is proposed... - Association of aspirin and nonaspirin nonsteroidal anti-inflammatory drugs with cancer incidence and mortalityAditya Bardia
Department of Internal Medicine, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
J Natl Cancer Inst 99:881-9. 2007..We evaluated associations between aspirin and nonaspirin NSAID use with cancer incidence and mortality stratified by smoking history in the Iowa Women's Health Study, a prospective cohort of postmenopausal women... 
Young-onset colorectal cancer in patients with no known genetic predisposition: can we increase early recognition and improve outcome?Eric J Dozois
Division of Colon and Rectal Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
Medicine (Baltimore) 87:259-63. 2008..Our findings should promote increased awareness and the aggressive pursuit of symptoms in otherwise young, low-risk patients, as these symptoms may represent an underlying colorectal malignancy...- Parent of origin effects on age at colorectal cancer diagnosisNoralane M Lindor
Department of Medical Genetics, Mayo Clinic, Rochester, MN, USA
Int J Cancer 127:361-6. 2010.... - Gene expression differences in normal esophageal mucosa associated with regression and progression of mild and moderate squamous dysplasia in a high-risk Chinese populationNina Joshi
Genetics Branch, Center for Cancer Research, National Cancer Institute/NIH, EPS, 6120 Executive Boulevard, Bethesda, MD 20892, USA
Cancer Res 66:6851-60. 2006..These data suggest that local and systemic immune responses may influence the natural history of esophageal squamous dysplasia... - Prepregnancy exposure to cigarette smoking and subsequent risk of postmenopausal breast cancerJanet E Olson
Division of Epidemiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Mayo Clin Proc 80:1423-8. 2005..To examine the association of cigarette smoking before first pregnancy with risk of postmenopausal breast cancer in a large population-based cohort... - Incidence of colorectal cancer in relation to glycemic index and load in a cohort of womenMary McCarl
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Suite 300, 1300 South Second Street, Minneapolis, MN 55454-1015, USA
Cancer Epidemiol Biomarkers Prev 15:892-6. 2006..CONCLUSION: Our findings suggest that high GI or GL are not major CRC risk factors among older women in general, but may increase CRC risk among women who are obese... - Epidemiology and prevention of colorectal cancerErnest T Hawk
Gastrointestinal and Other Cancers Research Group, National Cancer Institute, Division of Cancer Prevention, EPN, Suite 2141, 6130 Executive Boulevard, Bethesda, MD 20892 7317, USA
Surg Clin North Am 82:905-41. 2002..The challenges and rewards of participation in chemoprevention research--both as patients and health care providers-have never been greater... - Serum cytokine analysis in a positive chemoprevention trial: selenium, interleukin-2, and an association with squamous preneoplastic diseaseMark J Roth
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7232, USA
Cancer Prev Res (Phila) 3:810-7. 2010..The favorable effect of selenomethionine on esophageal dysplasia in the original trial may have been mediated in part by its effect in reducing the levels of IL-2... - Clinically confirmed type 2 diabetes mellitus and colorectal cancer risk: a population-based, retrospective cohort studyPaul J Limburg
Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Am J Gastroenterol 101:1872-9. 2006.... - Coffee phenolic phytochemicals suppress colon cancer metastasis by targeting MEK and TOPKNam Joo Kang
The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
Carcinogenesis 32:921-8. 2011..These results suggest that coffee and CaA target MEK1 and TOPK to suppress colon cancer metastasis and neoplastic cell transformation... - Antibacterial properties and toxicity of Atuna racemosa extract depend on kernel maturityEric J Buenz
Complementary and Integrative Medicine Program, Mayo Clinic College of Medicine, Rochester, MN, USA
J Ethnopharmacol 111:592-7. 2007..These findings have implications for the use of this natural product as an antibiotic and chemotherapeutic agent... - Helicobacter pylori seropositivity and colorectal cancer risk: a prospective study of male smokersPaul J Limburg
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA
Cancer Epidemiol Biomarkers Prev 11:1095-9. 2002..91 (0.53-1.55), respectively. Stratification by colorectal cancer subsite yielded similarly unremarkable results. On the basis of these data, H. pylori carriage does not appear to be an important risk factor for colorectal adenocarcinoma... - Assessing attitudes toward laxative preparation in colorectal cancer screening and effects on future testing: potential receptivity to computed tomographic colonographyTimothy J Beebe
Department of Health Sciences Research, College of Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
Mayo Clin Proc 82:666-71. 2007..The overall response rate was 49%. Analysis focused on the 759 respondents who were 50 years or older... - Colorectal cancer chemopreventionPaul J Limburg
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA
Chin J Dig Dis 5:7-11. 2004 - Colorectal cancer prognosis among patients with inflammatory bowel diseaseThierry Delaunoit
Department of Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Clin Gastroenterol Hepatol 4:335-42. 2006..The survival rates for IBD-associated and sporadic CRC were similar... - Body size and incident colorectal cancer: a prospective study of older womenAmy S Oxentenko
College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
Cancer Prev Res (Phila) 3:1608-20. 2010..e., early adulthood versus later adulthood) might also be informative, particularly with respect to defining subsite-specific pathways of colorectal carcinogenesis... - Efficacy of antioxidant supplementation in reducing primary cancer incidence and mortality: systematic review and meta-analysisAditya Bardia
Department of Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
Mayo Clin Proc 83:23-34. 2008..To estimate the association between antioxidant use and primary cancer incidence and mortality and to evaluate these effects across specific antioxidant compounds, target organs, and participant subgroups... - Prospective evaluation of fecal calprotectin as a screening biomarker for colorectal neoplasiaPaul J Limburg
Division of Gastroenterology and Hepatology and Department of Biostatistics, Mayo Clinic, Rochester, Minnesota 55905, USA
Am J Gastroenterol 98:2299-305. 2003..Further investigation of tumor-derived, rather than blood-based, biomarkers may be a more rewarding approach to stool screening for colorectal neoplasia... - Small bowel adenocarcinoma: a rare but aggressive diseaseThierry Delaunoit
Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA
Clin Colorectal Cancer 4:241-8; discussion 249-51. 2004..We reviewed the clinical aspects of this rare but aggressive disease, focusing on new diagnostic procedures as well as on recent advances in their therapeutic management... - Pathogenesis and risk factors of small bowel adenocarcinoma: a colorectal cancer sibling?Thierry Delaunoit
Department of Oncology, Molecular Medicine Program, and Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA
Am J Gastroenterol 100:703-10. 2005..Better understanding of sporadic and hereditary genetic pathways potentially involved will undoubtedly lead to better prevention and therapeutic management of this rare but aggressive disease... - Effect of slice thickness and primary 2D versus 3D virtual dissection on colorectal lesion detection at CT colonography in 452 asymptomatic adultsC Daniel Johnson
Department of Radiology, Mayo Clinic, 200 First St, SW, Rochester, MN 55905, USA
AJR Am J Roentgenol 189:672-80. 2007..The objective of our study was to compare the performance of primary 3D search using 360 degree virtual dissection with primary 2D search using a 2.5- versus a 1.25-mm slice thickness... - Colorectal cancer screening education, prioritization, and self-perceived preparedness among primary care residents: data from a national surveyAmy S Oxentenko
Mayo Clinic College of Medicine, Rochester, MN, USA
J Cancer Educ 22:208-18. 2007.... - Functional and clinical significance of variants localized to 8q24 in colon cancerMine S Cicek
Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street Southwest, 920 Hilton Building, Rochester, MN 55905, USA
Cancer Epidemiol Biomarkers Prev 18:2492-500. 2009..Finally, these risk alleles do not seem to be associated with survival... - Colorectal cancer screening perceptions and practices: results from a national survey of gastroenterology, surgery and radiology traineesAmy S Oxentenko
Mayo Clinic College of Medicine, Rochester, MN, USA
J Cancer Educ 22:219-26. 2007.... - Selenomethionine treatment does not alter gene expression in normal squamous esophageal mucosa in a high-risk Chinese populationNina Joshi
Amgen, 1201 Amgen Court West, AW1-J 4144, Seattle, WA 98119-3105, USA
Cancer Epidemiol Biomarkers Prev 15:1046-7. 2006.... - Accuracy of colorectal polyp self-reports: findings from the colon cancer family registryLisa Madlensky
Moores UCSD Cancer Center, 3855 Health Sciences Drive, MC0901, La Jolla, CA 92093 0901, USA
Cancer Epidemiol Biomarkers Prev 16:1898-901. 2007..However, it is not known how accurately patients are able to self-report the presence or absence of adenomas following colonoscopy... - Accuracy of CT colonography for detection of large adenomas and cancersC Daniel Johnson
Mayo Clinic Arizona, Scottsdale, AZ, USA
N Engl J Med 359:1207-17. 2008..Computed tomographic (CT) colonography is a noninvasive option in screening for colorectal cancer. However, its accuracy as a screening tool in asymptomatic adults has not been well defined... - Can selenium supplementation prevent colorectal cancer?Steven B Ingle
Gastroenterology 131:1646-7. 2006 - Second primary colorectal cancer: the consequence of management failure at several potential levelsPaul J Limburg
Ann Intern Med 136:335-7. 2002
Research Grants
- Insulin, the IGF Axis, and Colorectal NeoplasiaPaul Limburg; Fiscal Year: 2005..Following achievement of these goals, I am confident that I will be ready to continue my career as a successful independent investigator committed to academic research. ..
- Molecular Epidemiology of Colorectal Cancer SubtypesPaul Limburg; Fiscal Year: 2007....
- Molecular Epidemiology of Colorectal Cancer SubtypesPaul J Limburg; Fiscal Year: 2010....