J A Levine

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc New fat free mass - fat mass model for use in physiological energy balance equations
    Diana Thomas
    Department of Mathematical Sciences, Montclair State University, Montclair, NJ, USA
    Nutr Metab (Lond) 7:39. 2010
  2. pmc Adipocyte macrophage colony-stimulating factor is a mediator of adipose tissue growth
    J A Levine
    Department of Medicine, Endocrine Research Unit, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    J Clin Invest 101:1557-64. 1998
  3. pmc The energy expenditure of using a "walk-and-work" desk for office workers with obesity
    James A Levine
    Endocrine Research Unit, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Br J Sports Med 41:558-61. 2007
  4. ncbi request reprint Tracmor system for measuring walking energy expenditure
    J Levine
    Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    Eur J Clin Nutr 57:1176-80. 2003
  5. ncbi request reprint Labor saved, calories lost: the energetic impact of domestic labor-saving devices
    Lorraine Lanningham-Foster
    Endocrine Research Unit, 5 194 Joseph, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905, USA
    Obes Res 11:1178-81. 2003
  6. ncbi request reprint Aging on the job
    James Levine
    Mayo Clinic, Rochester, MN 55905, USA
    Sci Aging Knowledge Environ 2006:pe16. 2006
  7. ncbi request reprint Non-exercise activity thermogenesis
    James A Levine
    Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    Proc Nutr Soc 62:667-79. 2003
  8. ncbi request reprint Nonexercise activity thermogenesis (NEAT): environment and biology
    James A Levine
    Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    Am J Physiol Endocrinol Metab 286:E675-85. 2004
  9. ncbi request reprint Measurement of energy expenditure
    James A Levine
    Mayo Clinic, Endocrine Research Unit, Rochester, MN 55902, USA
    Public Health Nutr 8:1123-32. 2005
  10. ncbi request reprint NEAT--non-exercise activity thermogenesis--egocentric & geocentric environmental factors vs. biological regulation
    J A Levine
    Endocrine Research Unit, Mayo Clinic and Mayo Foundation, Rochester, MN, USA
    Acta Physiol Scand 184:309-18. 2005

Research Grants

  1. Instruments for measuring physical activity
    James Levine; Fiscal Year: 2007
  2. Non-exercise Activity Thermogenesis (NEAT)
    James Levine; Fiscal Year: 2005
  3. NEAT & Physical Activity Assessment in the Elderly
    James Levine; Fiscal Year: 2006
  4. Nutritional Restriction and Activity Thermogenesis
    James Levine; Fiscal Year: 2007
  5. Energy Expenditure and Gastric-Bypass Surgery
    James Levine; Fiscal Year: 2007

Collaborators

Detail Information

Publications62

  1. pmc New fat free mass - fat mass model for use in physiological energy balance equations
    Diana Thomas
    Department of Mathematical Sciences, Montclair State University, Montclair, NJ, USA
    Nutr Metab (Lond) 7:39. 2010
    ..Comparison of translates to a representative sample of the US population indicate that this parameter is a reflection of age, height, race and gender effects...
  2. pmc Adipocyte macrophage colony-stimulating factor is a mediator of adipose tissue growth
    J A Levine
    Department of Medicine, Endocrine Research Unit, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    J Clin Invest 101:1557-64. 1998
    ..We conclude that MCSF participates in adipocyte hyperplasia and the physiological regulation of adipose tissue growth...
  3. pmc The energy expenditure of using a "walk-and-work" desk for office workers with obesity
    James A Levine
    Endocrine Research Unit, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Br J Sports Med 41:558-61. 2007
    ..Our hypothesis was that a vertical workstation that allows an obese individual to work while walking would be associated with significant and substantial increases in energy expenditure over seated work...
  4. ncbi request reprint Tracmor system for measuring walking energy expenditure
    J Levine
    Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    Eur J Clin Nutr 57:1176-80. 2003
    ..The triaxial accelerometer for movement registration (Tracmor) is a valid measure of body displacement and so we wanted to evaluate this tool for quantifying walking-EE...
  5. ncbi request reprint Labor saved, calories lost: the energetic impact of domestic labor-saving devices
    Lorraine Lanningham-Foster
    Endocrine Research Unit, 5 194 Joseph, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905, USA
    Obes Res 11:1178-81. 2003
    ..However, there is a paucity of data to support this conclusion. In this study, we address the hypothesis that domestic mechanization of daily tasks has resulted in less energy expenditure compared with performing the same tasks manually...
  6. ncbi request reprint Aging on the job
    James Levine
    Mayo Clinic, Rochester, MN 55905, USA
    Sci Aging Knowledge Environ 2006:pe16. 2006
    ..Although the problem might be averted or at least minimized by implementing different employment policies, biological factors could overlay and supervene any economic planning...
  7. ncbi request reprint Non-exercise activity thermogenesis
    James A Levine
    Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    Proc Nutr Soc 62:667-79. 2003
    ..It then becomes intriguing to dissect mechanistic studies that delineate how NEAT is regulated by neural, peripheral and humoral factors. NEAT may be a carefully-regulated 'tank' of physical activity that is crucial for weight control...
  8. ncbi request reprint Nonexercise activity thermogenesis (NEAT): environment and biology
    James A Levine
    Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    Am J Physiol Endocrinol Metab 286:E675-85. 2004
    ..A scheme is described in this review in which NEAT corresponds to a carefully regulated "tank" of physical activity that is crucial for weight control...
  9. ncbi request reprint Measurement of energy expenditure
    James A Levine
    Mayo Clinic, Endocrine Research Unit, Rochester, MN 55902, USA
    Public Health Nutr 8:1123-32. 2005
    ..The factorial method for combining activity logs and data on the energy costs of activities can also provide detailed information on free-living subjects...
  10. ncbi request reprint NEAT--non-exercise activity thermogenesis--egocentric & geocentric environmental factors vs. biological regulation
    J A Levine
    Endocrine Research Unit, Mayo Clinic and Mayo Foundation, Rochester, MN, USA
    Acta Physiol Scand 184:309-18. 2005
    ..Deciphering the role of NEAT may lead to a better understanding of the pathogenesis, prevention and treatment of obesity...
  11. ncbi request reprint Nonexercise activity thermogenesis--liberating the life-force
    J A Levine
    Endocrine Research Unit, Mayo Clinic, Rochester, MN 5590, USA
    J Intern Med 262:273-87. 2007
    ..Data support the central hypothesis that NEAT is pivotal in the regulation of human energy expenditure and body weight regulation and that NEAT is important for understanding the cause and effective treatment for obesity...
  12. ncbi request reprint Effect of hyperthyroidism on spontaneous physical activity and energy expenditure in rats
    James A Levine
    Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Appl Physiol (1985) 94:165-70. 2003
    ..8 to 19.7 +/- 5.0 kcal/day (P < 0.001) but did not increase in the controls (8.7 +/- 3.5 cf 9.4 +/- 1.7 kcal/day; not significant). In conclusion, hyperthyroidism is associated with increased spontaneous physical activity and NEAT...
  13. ncbi request reprint Adenoviral-mediated gene transfer to human adipocytes in vitro, and human adipose tissue ex vivo and rabbit femoral adipose tissue in vivo
    J A Levine
    Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Nutr Sci Vitaminol (Tokyo) 44:569-72. 1998
    ..Adenoviral-mediated gene transfer may facilitate studies on understanding the biology of adipocytes and provide a potential tool for the modulation of adipocyte function in vivo and thereby for the treatment of obesity...
  14. ncbi request reprint Energy expenditure in chronic alcohol abuse
    J A Levine
    Mayo Clinic, Rochester, MN 55905, USA
    Eur J Clin Invest 30:779-86. 2000
    ..However, individuals who chronically abuse alcohol are not obese. To investigate this paradox, we measured energy expenditure (EE) and fuel utilization in chronic alcohol abusers in relation to their drinking behaviour...
  15. ncbi request reprint Energy expenditure of nonexercise activity
    J A Levine
    Endocrine Research Unit, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Am J Clin Nutr 72:1451-4. 2000
    ..A potentially important, yet seldom investigated, component of NEAT is the energy expenditure of fidgeting-like activities...
  16. doi request reprint Description and clinical studies of a device for the instantaneous detection of office-place stress
    James A Levine
    Experimental Office Facility, Centre on NEAT, Mayo Clinic, Rochester, MN 55905, USA
    Work 34:359-64. 2009
    ..96, P< 0.001). High-definition thermal imaging can be used for real-time detection of stress provocation. This technology may prove to be of help in ameliorating office-place stress...
  17. ncbi request reprint Measurement of the components of nonexercise activity thermogenesis
    J Levine
    Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Physiol Endocrinol Metab 281:E670-5. 2001
    ..This novel technology has potential application for not only assessing NEAT but also tracking physical activity in free-living humans...
  18. ncbi request reprint Obesity in China: causes and solutions
    James A Levine
    Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    Chin Med J (Engl) 121:1043-50. 2008
  19. pmc The Pol-e-pill finally arrives
    James A Levine
    Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Diabetes 57:1784-5. 2008
  20. ncbi request reprint Non-exercise activity thermogenesis: the crouching tiger hidden dragon of societal weight gain
    James A Levine
    Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    Arterioscler Thromb Vasc Biol 26:729-36. 2006
    ..To reverse obesity, we need to develop individual strategies to promote standing and ambulating time by 2.5 hours per day and also re-engineer our work, school, and home environments to render active living the option of choice...
  21. ncbi request reprint Central neural and endocrine mechanisms of non-exercise activity thermogenesis and their potential impact on obesity
    C M Novak
    Mayo Clinic, Endocrine Research Unit, Rochester, MN, USA
    J Neuroendocrinol 19:923-40. 2007
    ..The neural and endocrine systems that control NEAT are potential targets for the treatment of obesity...
  22. ncbi request reprint Feasibility of a walking workstation to increase daily walking
    W G Thompson
    Occupational and Aerospace Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Br J Sports Med 42:225-8; discussion 228. 2008
    ..A walking workstation that allows workers to walk while they work has the potential to increase caloric expenditure. We evaluated whether employees can and will use walking workstations while performing their jobs...
  23. ncbi request reprint Validation of the Tracmor triaxial accelerometer system for walking
    J A Levine
    Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    Med Sci Sports Exerc 33:1593-7. 2001
    ..The aim of this study was to validate the Tracmor triaxial accelerometer system for estimating the energy expenditure of walking...
  24. ncbi request reprint Is there a role for gastric accommodation and satiety in asymptomatic obese people?
    D Y Kim
    Enteric Neuroscience Program, Gastroenterology Research Unit, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Obes Res 9:655-61. 2001
    ..We hypothesized that obese people had increased gastric accommodation and reduced postprandial satiety. The objective of this study was to compare gastric accommodation and satiety between obese and non-obese asymptomatic subjects...
  25. ncbi request reprint Neuromedin U in the paraventricular and arcuate hypothalamic nuclei increases non-exercise activity thermogenesis
    C M Novak
    Endocrine Research Unit, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    J Neuroendocrinol 18:594-601. 2006
    ..In co-ordination with its suppressive effects on feeding, the NEAT-activating effects of NMU make it a potential candidate in the combat of obesity...
  26. pmc Preservation of macronutrient preferences in cancer anorexia
    J A Levine
    Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    Br J Cancer 78:579-81. 1998
    ..0 +/- 0.9 MJ vs 9.5 +/- 0.5 MJ, P < 0.001). However, macronutrient composition was consistently maintained in the patients with cancer anorexia. These data argue against cancer anorexia representing a state of macronutrient aversion...
  27. ncbi request reprint Gait and balance of transfemoral amputees using passive mechanical and microprocessor-controlled prosthetic knees
    K R Kaufman
    Motion Analysis Laboratory, Mayo Clinic, Rochester, MN 55905, USA
    Gait Posture 26:489-93. 2007
    ..These joints are more sophisticated and more expensive than mechanical ones. The literature is contradictory regarding changes in gait and balance when using these sophisticated devices...
  28. ncbi request reprint Differential effects of adrenocorticotropic hormone on human and mouse adipose tissue
    K Kiwaki
    Endocrine Research Unit, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    J Comp Physiol B 173:675-8. 2003
    ..ACTH receptor mRNA was present in mouse adipose tissue, but undetectable in human adipose tissue. These results suggest lipolysis regulation differs between human and mouse adipose tissue in response to ACTH...
  29. ncbi request reprint Adipose tissue metabolism in benign symmetric lipomatosis
    S Nielsen
    Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 86:2717-20. 2001
    ..The pathophysiology appears similar to what has been termed hyperplastic obesity. A better understanding of this condition could lead to insights into the mechanisms of hyperplastic obesity...
  30. ncbi request reprint Regional uptake of meal fatty acids in humans
    Michael D Jensen
    1Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Am J Physiol Endocrinol Metab 285:E1282-8. 2003
    ..Using [3H]triolein, we were able to account for virtually 100% of meal fatty acids 24 h after meal ingestion. These results support the meal fatty acid tracer model as a way to study the metabolic fate of dietary fat...
  31. pmc Sensitivity of the hypothalamic paraventricular nucleus to the locomotor-activating effects of neuromedin U in obesity
    Colleen M Novak
    Mayo Clinic, Endocrine Research Unit, St Marys Hospital, Joseph 5 194, 200 1st St SW, Rochester, MN 55905, USA
    Brain Res 1169:57-68. 2007
    ..Taken together with previous studies, these results suggest that obesity may represent a state associated with decreased central sensitivity to neuropeptides such as NMU that increase physical activity and therefore energy expenditure...
  32. ncbi request reprint Non-exercise activity thermogenesis (NEAT)
    James A Levine
    Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    Best Pract Res Clin Endocrinol Metab 16:679-702. 2002
    ..By understanding how NEAT is regulated we may come to appreciate that spontaneous physical activity is not spontaneous at all but carefully programmed...
  33. ncbi request reprint Looking at child labor
    James A Levine
    Science 296:1025-6. 2002
  34. ncbi request reprint Variability in energy expenditure and its components
    William T Donahoo
    Department of Medicine, Section of Endocrinology, Diabetes, and Metabolism, University of Vermont, Burlington, Vermont, USA
    Curr Opin Clin Nutr Metab Care 7:599-605. 2004
    ..For each component, the expected magnitude of intra-individual variability is also considered. We also reviewed studies that quantified the variability in 24 h energy expenditure...
  35. ncbi request reprint Design of posture and activity detector (PAD)
    Kara E Bliley
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Conf Proc IEEE Eng Med Biol Soc 2007:2659-63. 2007
    ..In this paper, the specifications for PAD will be outlined including its hardware and software components, and clinical research applications...
  36. ncbi request reprint The role of free-living daily walking in human weight gain and obesity
    James A Levine
    Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    Diabetes 57:548-54. 2008
    ..5 h/day more than lean counterparts. Here, we address the hypotheses that free-living daily walking distance is decreased in obesity compared with lean subjects and that experimental weight gain precipitates decreased daily walking...
  37. pmc Measurement of daily activity in restrictive type anorexia nervosa
    Ann M Harris
    Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
    Int J Eat Disord 41:280-3. 2008
    ..We wanted to test a daily activity detecting device named, the physical activity monitoring system (PAMS)...
  38. ncbi request reprint Obesity in neurobiology
    Stefan Knecht
    Department of Neurology, University of Munster, A Schweitzer Str 33, 48129 Munster, Germany
    Prog Neurobiol 84:85-103. 2008
    ..Changing the net balance of this system to prevent or reduce obesity requires multimodal and long-term interventions...
  39. ncbi request reprint Interindividual variation in posture allocation: possible role in human obesity
    James A Levine
    Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    Science 307:584-6. 2005
    ..If obese individuals adopted the NEAT-enhanced behaviors of their lean counterparts, they might expend an additional 350 calories (kcal) per day...
  40. pmc Energy expenditure and activity of transfemoral amputees using mechanical and microprocessor-controlled prosthetic knees
    Kenton R Kaufman
    Motion Analysis Laboratory, Mayo Clinic, Rochester, MN 55905, USA
    Arch Phys Med Rehabil 89:1380-5. 2008
    ..To quantify the energy efficiency of locomotion and free-living physical activity energy expenditure of transfemoral amputees using a mechanical and microprocessor-controlled prosthetic knee...
  41. ncbi request reprint Feeding and activity induced by orexin A in the lateral hypothalamus in rats
    Catherine M Kotz
    Veterans Affairs Medical Center, One Veterans Drive, Research Service 151, Minneapolis, MN 55417, USA
    Regul Pept 104:27-32. 2002
    ..These data show that LH orexin A stimulation of feeding is not always coincident with increased activity, suggesting that feeding induced by LH-injected orexin A is not consequent to enhanced arousal...
  42. ncbi request reprint Exercise: a walk in the park?
    James A Levine
    Mayo Clin Proc 82:797-8. 2007
  43. pmc Changing the school environment to increase physical activity in children
    Lorraine Lanningham-Foster
    Endocrine Research Unit, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Obesity (Silver Spring) 16:1849-53. 2008
    ..Children will move more in an activity-permissive environment. Strategies to increase the activity of school children may involve re-designing the school itself...
  44. ncbi request reprint Caloric restriction and physical activity in zebrafish (Danio rerio)
    Colleen M Novak
    Endocrine Research Unit, Mayo Clinic and Mayo Foundation, St Mary s Hospital, Rochester, MN 55905, USA
    Neurosci Lett 383:99-104. 2005
    ..Thus, the association between negative energy balance and reductions in PA occurs across genera in biology and is associated with predictable neurological changes in brain gene expression...
  45. ncbi request reprint Non-exercise activity thermogenesis (NEAT)
    James A Levine
    Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    Nutr Rev 62:S82-97. 2004
    ..It appears that changes in NEAT accompany experimentally induced changes in energy balance and may be important in the physiology of weight change. NEAT and a sedentary lifestyle may thus be of profound importance in obesity...
  46. ncbi request reprint Precision and accuracy of an ankle-worn accelerometer-based pedometer in step counting and energy expenditure
    Randal C Foster
    Endocrine Research Unit, Division of Endocrinology, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Prev Med 41:778-83. 2005
    ..In this paper, we investigate the precision and accuracy of an ankle-worn dual-axis accelerometer (Stepwatch) and investigate its potential application as a predictor of energy expenditure...
  47. ncbi request reprint Central orexin sensitivity, physical activity, and obesity in diet-induced obese and diet-resistant rats
    Colleen M Novak
    Endocrine Research Unit, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA
    Am J Physiol Endocrinol Metab 290:E396-403. 2006
    ..A putative mechanism for changes in NEAT that accompany obesity is a decreased sensitivity to the NEAT-activating effects of neuropeptides such as orexin...
  48. ncbi request reprint Laboratory measurement of posture allocation and physical activity in children
    Lorraine M Lanningham-Foster
    Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    Med Sci Sports Exerc 37:1800-5. 2005
    ..The purpose of this study was to validate the combined use of inclinometers and accelerometers to measure body posture and movement in children in a laboratory setting...
  49. ncbi request reprint Commercially available pedometers: considerations for accurate step counting
    Edward L Melanson
    Center for Human Nutrition, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Prev Med 39:361-8. 2004
    ..We examined the effects of age, obesity, and self-selected walking speed on pedometer accuracy. We also compared the accuracy of piezoelectric and spring-levered pedometers at slow walking speeds...
  50. ncbi request reprint Role of nonexercise activity thermogenesis (NEAT) in obesity
    Catherine M Kotz
    Veterans Affairs Medical Center, Minneapolis, Minnesota, USA
    Minn Med 88:54-7. 2005
    ..This article reviews the evidence for NEAT and the impact of NEAT on obesity...
  51. ncbi request reprint Weekly changes in basal metabolic rate with eight weeks of overfeeding
    Ann M Harris
    Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    Obesity (Silver Spring) 14:690-5. 2006
    ..Our hypothesis was that BMR does not increase linearly with 1000-kcal/d overfeeding in lean healthy subjects over 8 weeks. The null hypothesis states that BMR increases linearly with 1000-kcal/d overfeeding in lean healthy subjects...
  52. ncbi request reprint Orexin A (hypocretin 1) injected into hypothalamic paraventricular nucleus and spontaneous physical activity in rats
    Kohji Kiwaki
    Endocrine Research Unit, Joseph 5 194, Mayo Clinic Rochester, 200 First Street SW, Rochester, MN 55905, USA
    Am J Physiol Endocrinol Metab 286:E551-9. 2004
    ..Thus orexin A can act in PVN to increase nonfeeding-associated physical activity, suggesting that this neuropeptide might be a mediator of NEAT...
  53. ncbi request reprint Impact of endurance training on murine spontaneous activity, muscle mitochondrial DNA abundance, gene transcripts, and function
    Lisa S Chow
    Division of Endocrinology, Nutrition and Metabolism, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Appl Physiol 102:1078-89. 2007
    ....
  54. ncbi request reprint Treatment of obesity
    Warren G Thompson
    Division of Preventive, Occupational and Aerospace Medicine, Mayo Clinic College of Medicne, 200 First St SW, Rochester, MN 55905, USA
    Mayo Clin Proc 82:93-101; quiz 101-2. 2007
    ..Medication and surgical approaches may be appropriate as well. This review outlines the evidence for each approach, suggests how primary care physicians can best help obese patients, and provides practical tips for weight loss...
  55. ncbi request reprint Nonexercise movement in elderly compared with young people
    Ann M Harris
    Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    Am J Physiol Endocrinol Metab 292:E1207-12. 2007
    ..Thus, the energetic cost of walking in the elderly may be greater than in the young. Lean, healthy elderly individuals may have a biological drive to be less active than the young...
  56. pmc An office-place stepping device to promote workplace physical activity
    David A McAlpine
    Mayo Clinic, 200 First St SW, Rochester 55905, USA
    Br J Sports Med 41:903-7. 2007
    ..The objective was to assess the effect of using an office-place stepping device on the energy expenditure of lean and obese office workers...
  57. ncbi request reprint Body composition profiles derived from dual-energy X-ray absorptiometry, total body scan, and mortality
    Jesse C Krakauer
    Northpointe Health Center, Berkley, MI 48072 1853, USA
    Prev Cardiol 7:109-15. 2004
    ..02). The authors propose that DXA-body composition profiles can identify increased mortality risk of magnitude similar to major cardiovascular risk factors and may prove useful in health assessment...
  58. ncbi request reprint Energy expenditure of sedentary screen time compared with active screen time for children
    Lorraine Lanningham-Foster
    Endocrine Research Unit, Mayo Clinic, 200 First St, SW, Rochester, MN 55905, USA
    Pediatrics 118:e1831-5. 2006
    ..Our hypothesis was that energy expenditure would be significantly greater when children played activity-promoting video games, compared with sedentary video games...
  59. ncbi request reprint Galectin-3 stimulates preadipocyte proliferation and is up-regulated in growing adipose tissue
    Kohji Kiwaki
    Endocrine Research Unit, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Obesity (Silver Spring) 15:32-9. 2007
    ..To probe the molecular basis of obesity, this study determined whether galectin-3 was present in adipose tissue and investigated its effects on fat cell number...
  60. ncbi request reprint The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet-induced obesity
    Maria Thereza P Barbosa
    Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    FASEB J 21:3629-39. 2007
    ..Thus, together these results identify a novel pathway regulating body weight and clearly show that CD38 is a nearly obligatory component of the cellular cascade that led to diet-induced obesity...

Research Grants7

  1. Instruments for measuring physical activity
    James Levine; Fiscal Year: 2007
    ..This should allow us to better define the role of physical activity in health and disease. ..
  2. Non-exercise Activity Thermogenesis (NEAT)
    James Levine; Fiscal Year: 2005
    ..In addition, these studies may provide information regarding the pathogenesis of obesity and potentially into novel modalities for preventing and treating obesity. ..
  3. NEAT & Physical Activity Assessment in the Elderly
    James Levine; Fiscal Year: 2006
    ..These studies may potentially guide us to devise novel strategies to prevent sarcopenia and promote physical activity in the elderly. ..
  4. Nutritional Restriction and Activity Thermogenesis
    James Levine; Fiscal Year: 2007
    ..1 2 Description, ..
  5. Energy Expenditure and Gastric-Bypass Surgery
    James Levine; Fiscal Year: 2007
    ..This may have dramatic implications for bariatric surgery and obesity management in general. ..