AMIR contact LERMAN

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Personalized medicine in cardiovascular diseases
    Moo Sik Lee
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA Department of Preventive Medicine, College of Medicine, Konyang University, Daejeon, Korea
    Korean Circ J 42:583-91. 2012
  2. pmc Humanin, a cytoprotective peptide, is expressed in carotid atherosclerotic [corrected] plaques in humans
    David G Zacharias
    Division of Cardiovascular Diseases, Department of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
    PLoS ONE 7:e31065. 2012
  3. pmc The importance of functional tests in personalized medicine
    R Jay Widmer
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic and College of Medicine, Rochester, MN, USA
    Rambam Maimonides Med J 4:e0014. 2013
  4. pmc Patients with an HbA1c in the prediabetic and diabetic range have higher numbers of circulating cells with osteogenic and endothelial progenitor cell markers
    Andreas J Flammer
    Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 97:4761-8. 2012
  5. pmc Vasoprotective effects of human CD34+ cells: towards clinical applications
    Thomas J Kiernan
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    J Transl Med 7:66. 2009
  6. doi request reprint Coronary endothelial dysfunction is associated with a reduction in coronary artery compliance and an increase in wall shear stress
    Takuro Takumi
    Division of Cardiovascular Disease, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    Heart 96:773-8. 2010
  7. ncbi request reprint Lipoprotein-associated phospholipase A2: a risk marker or a risk factor?
    Amir Lerman
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Am J Cardiol 101:11F-22F. 2008
  8. pmc The association between renal atherosclerotic plaque characteristics and renal function before and after renal artery intervention
    Takuro Takumi
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 86:1165-72. 2011
  9. ncbi request reprint Evaluation of microvascular anatomy by micro-CT
    A Lerman
    Department of Physiology and Biophysics, Mayo Clinic and Foundation, Rochester, Minnesota, USA
    Herz 24:531-3. 1999
  10. ncbi request reprint Endothelial function: cardiac events
    Amir Lerman
    Division of Cardiovascular Disease and Department of Internal Medicine, Mayo College of Medicine, 200 First St SW, Rochester, MN 55902, USA
    Circulation 111:363-8. 2005

Detail Information

Publications91

  1. pmc Personalized medicine in cardiovascular diseases
    Moo Sik Lee
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA Department of Preventive Medicine, College of Medicine, Konyang University, Daejeon, Korea
    Korean Circ J 42:583-91. 2012
    ..Ultimately, personalized medicine will affect the entire landscape of health care system in the near future...
  2. pmc Humanin, a cytoprotective peptide, is expressed in carotid atherosclerotic [corrected] plaques in humans
    David G Zacharias
    Division of Cardiovascular Diseases, Department of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
    PLoS ONE 7:e31065. 2012
    ..Humanin (HN) is a newly emerging endogenously expressed cytoprotective peptide. Our goal was to determine the presence and localization of HN in carotid atherosclerotic plaques...
  3. pmc The importance of functional tests in personalized medicine
    R Jay Widmer
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic and College of Medicine, Rochester, MN, USA
    Rambam Maimonides Med J 4:e0014. 2013
    ....
  4. pmc Patients with an HbA1c in the prediabetic and diabetic range have higher numbers of circulating cells with osteogenic and endothelial progenitor cell markers
    Andreas J Flammer
    Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 97:4761-8. 2012
    ..Vascular calcification, an important feature of diabetic vasculopathy, is an active process potentially mediated by endothelial progenitor cells (EPCs) coexpressing the osteoblastic marker osteocalcin (OCN)...
  5. pmc Vasoprotective effects of human CD34+ cells: towards clinical applications
    Thomas J Kiernan
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    J Transl Med 7:66. 2009
    ..We used a novel immunodeficient rat carotid injury model in order to determine whether human cells could improve vascular remodelling following acute injury...
  6. doi request reprint Coronary endothelial dysfunction is associated with a reduction in coronary artery compliance and an increase in wall shear stress
    Takuro Takumi
    Division of Cardiovascular Disease, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    Heart 96:773-8. 2010
    ..The purpose of this study was to investigate the association between coronary endothelial dysfunction, coronary artery compliance and wall shear stress in patients with early atherosclerosis...
  7. ncbi request reprint Lipoprotein-associated phospholipase A2: a risk marker or a risk factor?
    Amir Lerman
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Am J Cardiol 101:11F-22F. 2008
    ..The purpose of this article is to review the evidence for the clinical utility of Lp-PLA(2), both as a risk marker and as a risk factor involved in the causal pathway of plaque inflammation and the formation of rupture-prone plaque...
  8. pmc The association between renal atherosclerotic plaque characteristics and renal function before and after renal artery intervention
    Takuro Takumi
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 86:1165-72. 2011
    ..To evaluate the effect of plaque composition on renal function after renal artery intervention (RAI)...
  9. ncbi request reprint Evaluation of microvascular anatomy by micro-CT
    A Lerman
    Department of Physiology and Biophysics, Mayo Clinic and Foundation, Rochester, Minnesota, USA
    Herz 24:531-3. 1999
    ..The current review summarizes our current advances in using this technique in visualization of the coronary circulation...
  10. ncbi request reprint Endothelial function: cardiac events
    Amir Lerman
    Division of Cardiovascular Disease and Department of Internal Medicine, Mayo College of Medicine, 200 First St SW, Rochester, MN 55902, USA
    Circulation 111:363-8. 2005
  11. ncbi request reprint New insight and therapeutic strategies in cardiovascular disease and focus on endothelial target: endothelin-1 and angina
    A Lerman
    Department of Internal Medicine, Mayo Clinic Rochester, Minnesota 55905, USA
    J Cardiovasc Pharmacol 38:S27-30. 2001
    ....
  12. ncbi request reprint Microcirculatory dysfunction in ST-elevation myocardial infarction: cause, consequence, or both?
    Amir Lerman
    Division of Cardiovascular Disease, Department of Internal Medicine, Mayo Clinic and College of Medicine, 200 First Street SW, Rochester, MN 55902, USA
    Eur Heart J 28:788-97. 2007
    ..In the current work, we aimed at reviewing the role of the coronary microcirculation in the development and outcome of this acute coronary syndrome entity...
  13. ncbi request reprint Long-term L-arginine supplementation improves small-vessel coronary endothelial function in humans
    A Lerman
    Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minn 55905, USA
    Circulation 97:2123-8. 1998
    ....
  14. ncbi request reprint Relation of depression to coronary endothelial function
    Eric H Yang
    Center of Coronary Physiology and Imaging, Division of Cardiovascular Diseases, Mayo College of Medicine, Rochester, Minnesota, USA
    Am J Cardiol 99:1134-6. 2007
    ..It is, however, associated with a cluster of cardiac risk factors that are linked to the progression of atherosclerotic disease...
  15. ncbi request reprint Role of renal cortical neovascularization in experimental hypercholesterolemia
    Alejandro R Chade
    Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Hypertension 50:729-36. 2007
    ..This study, therefore, suggests that neovascularization in the hypercholesterolemic kidney is a compensatory mechanism that sustains basal renal vascular function...
  16. ncbi request reprint Early experimental obesity is associated with coronary endothelial dysfunction and oxidative stress
    Offer Galili
    Department of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Am J Physiol Heart Circ Physiol 292:H904-11. 2007
    ..Vascular dysfunction is therefore an early manifestation of obesity and might contribute to the increased cardiovascular risk, independently of insulin resistance...
  17. pmc Coronary artery endothelial dysfunction is positively correlated with low density lipoprotein and inversely correlated with high density lipoprotein subclass particles measured by nuclear magnetic resonance spectroscopy
    Monique A Ford
    Division of Cardiovascular Diseases, Mayo Clinic Rochester, United States
    Atherosclerosis 207:111-5. 2009
    ..The association between cholesterol and endothelial dysfunction remains controversial. We tested the hypothesis that lipoprotein subclasses are associated with coronary endothelial dysfunction...
  18. ncbi request reprint Simvastatin preserves myocardial perfusion and coronary microvascular permeability in experimental hypercholesterolemia independent of lipid lowering
    Piero O Bonetti
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 40:546-54. 2002
    ....
  19. ncbi request reprint Autologous culture-modified mononuclear cells confer vascular protection after arterial injury
    Rajiv Gulati
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minn 55905, USA
    Circulation 108:1520-6. 2003
    ..To test the hypothesis that delivery of autologous culture-modified mononuclear cells (CMMCs) to injured arteries could attenuate the vascular response to injury, a rabbit model was studied...
  20. ncbi request reprint Simvastatin preserves the structure of coronary adventitial vasa vasorum in experimental hypercholesterolemia independent of lipid lowering
    Stephanie H Wilson
    Divisions of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Circulation 105:415-8. 2002
    ..We aimed to determine the effect of simvastatin on coronary VV neovascularization, in the absence of cholesterol lowering...
  21. ncbi request reprint Increased ubiquitin immunoreactivity in unstable atherosclerotic plaques associated with acute coronary syndromes
    Joerg Herrmann
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 40:1919-27. 2002
    ..The current study was designed to examine whether ubiquitin expression is higher in unstable than in stable lesions of patients with acute coronary syndrome (ACS)...
  22. ncbi request reprint Local production of lipoprotein-associated phospholipase A2 and lysophosphatidylcholine in the coronary circulation: association with early coronary atherosclerosis and endothelial dysfunction in humans
    Shahar Lavi
    Division of Cardiovascular Diseases, Mayo Clinic, Mary Brigh 4 523, First ST SW, Rochester, MN 55905, USA
    Circulation 115:2715-21. 2007
    ..Inflammation also is associated with coronary atherosclerosis. We tested the hypothesis that local coronary production of Lp-PLA2 is enhanced in patients with early coronary atherosclerosis and associated with local endothelial function...
  23. ncbi request reprint Myocardial bridging is associated with alteration in coronary vasoreactivity
    Joerg Herrmann
    Division of Cardiovascular Diseases, Mayo Clinic Rochester, 200 First Street S W, Rochester, MN 55905, USA
    Eur Heart J 25:2134-42. 2004
    ..Myocardial bridging is a congenital condition associated with alteration in shear stress, however, its impact upon vasoreactivity remains undetermined...
  24. ncbi request reprint Chronic endothelin receptor antagonism prevents coronary vasa vasorum neovascularization in experimental hypercholesterolemia
    Joerg Herrmann
    Division of Cardiovascular Diseases, Mayo Clinic Rochester, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 39:1555-61. 2002
    ..The purpose of this study was to test the hypothesis that endothelin (ET) receptor antagonism reduces coronary vasa vasorum neovascularization in experimental hypercholesterolemia...
  25. ncbi request reprint Modulation of the vascular response to injury by autologous blood-derived outgrowth endothelial cells
    Rajiv Gulati
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic College of Medicine, ochester, MN 55905, USA
    Am J Physiol Heart Circ Physiol 287:H512-7. 2004
    ..Moreover, delivery of OECs confers greater vascular protection than PBMCs or saline controls and may thus offer a novel, autologous strategy to limit the response to mechanical injury...
  26. ncbi request reprint Impaired myocardial perfusion reserve in experimental hypercholesterolemia is independent of myocardial neovascularization
    Dallit Mannheim
    Division of Cardiovascular Diseases, Mayo Clinic Rochester, 200 First Street SW, Rochester, MN 55905, USA
    Am J Physiol Heart Circ Physiol 292:H2449-58. 2007
    ..This suggests that the myocardial neovascularization may not contribute to the attenuated myocardial perfusion response in hypercholesterolemia...
  27. ncbi request reprint Lipoprotein-associated phospholipase A2 is an independent marker for coronary endothelial dysfunction in humans
    Eric H Yang
    Division of Cardiovascular Diseases, Mayo College of Medicine, Rochester, MN 55905, USA
    Arterioscler Thromb Vasc Biol 26:106-11. 2006
    ..The purpose of the current study was to determine whether lipoprotein-associated phospholipase A2 (Lp-PLA2) is associated with coronary endothelial dysfunction and is a predictor of endothelial dysfunction in humans...
  28. ncbi request reprint Chronic proteasome inhibition contributes to coronary atherosclerosis
    Joerg Herrmann
    Division of Cardiovascular Diseases, Mayo Clinic and College of Medicine, Rochester, MN 55905, USA
    Circ Res 101:865-74. 2007
    ..These findings support the significance of the proteasome and related protein quality control for vascular biology and pathology...
  29. pmc The dynamic vasa vasorum
    Erik L Ritman
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Cardiovasc Res 75:649-58. 2007
    ..g., red blood cells, macrophages, inflammatory products) which attract monocytes, and response of vasa vasorum to pharmacological stimuli...
  30. ncbi request reprint Coronary endothelial dysfunction and hyperlipidemia are independently associated with diastolic dysfunction in humans
    Ahmad A Elesber
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Am Heart J 153:1081-7. 2007
    ..The objective of the this study was to determine if CED and CAD factors are associated with diastolic dysfunction before the development of occlusive CAD or clinical heart failure...
  31. pmc Myocardial microvascular function during acute coronary artery stenosis: effect of hypertension and hypercholesterolaemia
    Xiang Yang Zhu
    Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Cardiovasc Res 83:371-80. 2009
    ..We tested the hypothesis that new microvessels that proliferate in early atherosclerosis may be associated with myocardial protection during acute subtotal coronary artery obstruction (CAO)...
  32. ncbi request reprint Isolated elevation in troponin T after percutaneous coronary intervention is associated with higher long-term mortality
    Abhiram Prasad
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 48:1765-70. 2006
    ..The aim of this study was to evaluate whether, in patients with normal post-procedure CK-MB, an isolated elevation in cardiac troponin T (cTnT) predicts long-term survival...
  33. pmc Lack of correlation between noninvasive stress tests and invasive coronary vasomotor dysfunction in patients with nonobstructive coronary artery disease
    Andrew Cassar
    Department of Internal Medicine, Mayo College of Medicine, Rochester, MN 55905, USA
    Circ Cardiovasc Interv 2:237-44. 2009
    ..The ability of noninvasive stress tests to predict coronary vasomotor dysfunction in patients with nonobstructive coronary artery disease is unknown...
  34. doi request reprint Potential role of the ubiquitin-proteasome system in atherosclerosis: aspects of a protein quality disease
    Joerg Herrmann
    Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 51:2003-10. 2008
    ..This review summarizes these recent findings with a focus on atherosclerosis. In particular, this paper reflects on the viewpoint of atherosclerosis as a protein quality disease...
  35. ncbi request reprint Hypertension and hypercholesterolemia differentially affect the function and structure of pig carotid artery
    Daniele Versari
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Hypertension 50:1063-8. 2007
    ..Hypercholesterolemia is, in turn, associated with vasa vasorum neovascularization. These data suggest that carotid atherosclerosis can evolve through different mechanisms in relation to different risk factors...
  36. pmc Simvastatin decreases endothelial progenitor cell apoptosis in the kidney of hypertensive hypercholesterolemic pigs
    Ronit Lavi
    Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Arterioscler Thromb Vasc Biol 30:976-83. 2010
    ..We hypothesized that simvastatin improves the survival of endothelial progenitor cells (EPC) in the renal microenvironment imposed by concurrent renovascular hypertension and dietary hypercholesterolemia (HTC)...
  37. pmc Prevention of vasa vasorum neovascularization attenuates early neointima formation in experimental hypercholesterolemia
    Mario Gossl
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN, USA
    Basic Res Cardiol 104:695-706. 2009
    ..Serum levels of hs-CRP and TNF-alpha did not differ among the groups. Our study supports a role of VV neovascularization in the development of and a therapeutic potential for anti-angiogenic intervention in early atherosclerosis...
  38. pmc Phase-contrast MRI-based elastography technique detects early hypertensive changes in ex vivo porcine aortic wall
    David A Woodrum
    Radiology Department, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Magn Reson Imaging 29:583-7. 2009
    ..To measure the elastic properties of ex vivo porcine aortas in control and hypertensive groups using a phase contrast magnetic resonance imaging (MRI)-based elastography technique...
  39. pmc Osteocalcin expression by circulating endothelial progenitor cells in patients with coronary atherosclerosis
    Mario Gossl
    Division of Cardiology, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 52:1314-25. 2008
    ..This study was designed to test whether patients with coronary atherosclerosis have increases in circulating endothelial progenitor cells (EPCs) expressing an osteogenic phenotype...
  40. pmc Frailty and its potential relevance to cardiovascular care
    Mandeep Singh
    Division of Cardiovascular Diseases, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Mayo Clin Proc 83:1146-53. 2008
    ..We also elaborate on reasons to consider frailty in older adults with cardiovascular disease and focus on its early identification, on referral to specialists, and on care after serious cardiac events...
  41. pmc Mortality differences between men and women after percutaneous coronary interventions. A 25-year, single-center experience
    Mandeep Singh
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 51:2313-20. 2008
    ..Our aim was to examine whether gender-based differences in mortality after percutaneous coronary interventions (PCIs) have changed in the past 25 years...
  42. pmc Global cardiovascular reserve dysfunction in heart failure with preserved ejection fraction
    Barry A Borlaug
    Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 56:845-54. 2010
    ..The purpose of this study was to comprehensively examine cardiovascular reserve function with exercise in patients with heart failure and preserved ejection fraction (HFpEF)...
  43. doi request reprint Apical ballooning syndrome (Tako-Tsubo or stress cardiomyopathy): a mimic of acute myocardial infarction
    Abhiram Prasad
    The Division of Cardiovascular Diseases and Department of Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Am Heart J 155:408-17. 2008
    ....
  44. ncbi request reprint Smoking is associated with epicardial coronary endothelial dysfunction and elevated white blood cell count in patients with chest pain and early coronary artery disease
    Shahar Lavi
    Division of Cardiovascular Diseases, Mayo College of Medicine, Rochester, MN 55905, USA
    Circulation 115:2621-7. 2007
    ..The present study was designed to test the hypothesis that smoking is associated with epicardial coronary endothelial dysfunction and inflammation...
  45. ncbi request reprint Early changes in coronary artery wall structure detected by microcomputed tomography in experimental hypercholesterolemia
    Xiang Yang Zhu
    Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Am J Physiol Heart Circ Physiol 293:H1997-2003. 2007
    ..Therefore, this technique can be a useful tool in atherosclerosis research...
  46. ncbi request reprint Relation of preprocedural statin therapy to in-hospital procedural complications following percutaneous coronary interventions in patients with hyperlipidemia
    Mandeep Singh
    The Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Am J Cardiol 98:325-30. 2006
    ..In conclusion, hyperlipidemia per se is not associated with lower in-hospital complications after PCI. The benefit is largely limited to patients on statin treatment...
  47. ncbi request reprint Systematic review: transient left ventricular apical ballooning: a syndrome that mimics ST-segment elevation myocardial infarction
    Kevin A Bybee
    Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Ann Intern Med 141:858-65. 2004
    ..An episode of emotional or physiologic stress frequently precedes presentation with the syndrome. The in-hospital mortality rate seems to be low, as does the risk for recurrence...
  48. ncbi request reprint The ubiquitin-proteasome system in cardiovascular diseases-a hypothesis extended
    Joerg Herrmann
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Cardiovasc Res 61:11-21. 2004
    ..This review summarizes recent findings regarding the ubiquitin-proteasome system in cardiovascular diseases and discusses the potential use of proteasome inhibitors in cardiovascular therapy...
  49. ncbi request reprint Long-term antioxidant intervention improves myocardial microvascular function in experimental hypertension
    Martin Rodriguez-Porcel
    Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, 200 First St SW, Rochester, Minn 55905, USA
    Hypertension 43:493-8. 2004
    ..These results support the involvement of oxidative stress in myocardial vascular dysfunction in hypertension and suggest a role for antioxidant strategies to preserve the myocardial microvasculature...
  50. ncbi request reprint Clinical characteristics and thrombolysis in myocardial infarction frame counts in women with transient left ventricular apical ballooning syndrome
    Kevin A Bybee
    Division of Cardiovascular Diseases and Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Am J Cardiol 94:343-6. 2004
    ..TIMI frame counts were abnormal in all patients and often abnormal in all 3 major coronary vessels, suggesting that the diffuse impairment of coronary microcirculatory function may play a role in the pathogenesis of the syndrome...
  51. ncbi request reprint The ubiquitin-proteasome system--micro target for macro intervention?
    Joerg Herrmann
    Division of Cardiovascular Diseases Mayo Clinic, Rochester, MN 55905, USA
    Int J Cardiovasc Intervent 7:5-13. 2005
    ....
  52. ncbi request reprint Abnormal coronary microvascular endothelial function in humans with asymptomatic left ventricular dysfunction
    Abhiram Prasad
    Division of Cardiovascular Diseases and Department of Internal Medicine, Center for Coronary Physiology and Imaging, Mayo Clinic and Mayo Foundation, Rochester, Minn 55905, USA
    Am Heart J 146:549-54. 2003
    ..Thus, the current study was designed to test the hypothesis that coronary endothelial dysfunction is present in patients with asymptomatic left ventricular dysfunction...
  53. pmc Functional and structural remodeling of the myocardial microvasculature in early experimental hypertension
    Martin Rodriguez-Porcel
    Department of Internal Medicine, Division of Cardiovascular Disease, Mayo Clinic College of Medicine, 200 First St SW, Rochester, Minnesota 55905, USA
    Am J Physiol Heart Circ Physiol 290:H978-84. 2006
    ..These observations underscore the direct and early effects of HT on the myocardial vasculature...
  54. pmc Monocyte chemoattractant proteins mediate myocardial microvascular dysfunction in swine renovascular hypertension
    Jing Lin
    Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, USA
    Arterioscler Thromb Vasc Biol 29:1810-6. 2009
    ..This study tested the hypothesis that MCPs regulate cardiac microvascular function and structure in experimental HTN...
  55. ncbi request reprint Chronic antioxidant supplementation impairs coronary endothelial function and myocardial perfusion in normal pigs
    Daniele Versari
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN, USA
    Hypertension 47:475-81. 2006
    ....
  56. ncbi request reprint Antioxidant intervention prevents renal neovascularization in hypercholesterolemic pigs
    Alejandro R Chade
    Department of Internal Medicine Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Am Soc Nephrol 15:1816-25. 2004
    ..Chronic antioxidant supplementation may preserve the kidney in HC...
  57. pmc Disparate effects of simvastatin on angiogenesis during hypoxia and inflammation
    Xiang Yang Zhu
    Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, United States
    Life Sci 83:801-9. 2008
    ..This study tested the hypothesis that the angiogenic potential of simvastatin is related to the microenvironmental conditions...
  58. ncbi request reprint Bosentan preserves endothelial function in mice overexpressing APP
    Ahmad A Elesber
    Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Neurobiol Aging 27:446-50. 2006
    ..The current study demonstrates the presence of endothelial dysfunction in both carotid and aortic arteries in mice overexpressing APP and suggests a pathophysiological role for the endogenous endothelin system in AD...
  59. ncbi request reprint Differential effect of experimental hypertension and hypercholesterolemia on adventitial remodeling
    Joerg Herrmann
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic Rochester, MN 55905, USA
    Arterioscler Thromb Vasc Biol 25:447-53. 2005
    ..Intima-media remodeling, as frequently assessed by changes in the external elastic lamina-to-lumen area (EELLA), is well-described in coronary artery disease in contrast to adventitial remodeling, especially in the early disease stage...
  60. ncbi request reprint Antioxidant intervention attenuates myocardial neovascularization in hypercholesterolemia
    Xiang Yang Zhu
    Department of Internal Medicine, Division of Hypertension, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Circulation 109:2109-15. 2004
    ..We tested the hypothesis that chronic antioxidant intervention in HC would attenuate neovascularization and preserve the expression of hypoxia-inducible factor (HIF)-1alpha and vascular endothelial growth factor (VEGF)...
  61. ncbi request reprint Placenta growth factor expression in human atherosclerotic carotid plaques is related to plaque destabilization
    Kevin Pilarczyk
    Division of Cardiovascular Diseases, Mayo Clinic Rochester, 200 First Street SW, Rochester, MN, USA
    Atherosclerosis 196:333-40. 2008
    ..This study was designed to test the hypothesis that PlGF-expression in human atherosclerotic carotid plaques is related to inflammation, vascularization and clinical plaque instability...
  62. ncbi request reprint Relation of Thrombolysis in Myocardial Infarction (TIMI) frame count to coronary flow parameters
    Cem Barcin
    Division of Cardiovascular Disease, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Cardiol 91:466-9. 2003
  63. ncbi request reprint Pulse transmission coefficient: a nonhyperemic index for physiologic assessment of procedural success following percutaneous coronary interventions
    David Brosh
    Cardiovascular Division, Mayo Clinic Foundation, Rochester, Minnesota 55902, USA
    Catheter Cardiovasc Interv 61:95-102. 2004
    ..Similar to FFR, PTC is significantly increased following PCI. Thus, it may serve as an adjunct index for the functional assessment of procedural success following PCI...
  64. ncbi request reprint The interaction between coronary endothelial dysfunction, local oxidative stress, and endogenous nitric oxide in humans
    Shahar Lavi
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minn 55905, USA
    Hypertension 51:127-33. 2008
    ..This study supports the hypothesis that local oxidative stress has a role in reduction of NO bioavailability in humans with coronary endothelial dysfunction...
  65. ncbi request reprint Increased spatial vasa vasorum density in the proximal LAD in hypercholesterolemia--implications for vulnerable plaque-development
    Mario Gossl
    Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN 55905, United States
    Atherosclerosis 192:246-52. 2007
    ..To investigate further the possible role of VV spatial distribution in determining this predominantly proximal location of complex lesions we analyzed the changes in VV spatial densities along the LAD in early atherosclerosis...
  66. ncbi request reprint Ubiquitin and ubiquitin-like proteins in protein regulation
    Joerg Herrmann
    Division of Cardiovascular Diseases, Mayo Clinic Rochester, Rochester, MN 55905, USA
    Circ Res 100:1276-91. 2007
    ..This review provides an overview of this class of molecules and its implication for function, subcellular location, and half-life of proteins...
  67. ncbi request reprint Lipoprotein-associated phospholipase A(2) : review of its role as a marker and a potential participant in coronary endothelial dysfunction
    Shahar Lavi
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA
    Mol Diagn Ther 11:219-26. 2007
    ..This review provides an overview of these studies, suggests plausible mechanisms for the association between endothelial dysfunction and Lp-PLA(2), and highlights future potential therapies...
  68. ncbi request reprint Experimental hypercholesterolemia differentially affects adventitial vasa vasorum and vessel structure of the left internal thoracic and coronary arteries
    Offer Galili
    Division of Cardiovascular Diseases, Mayo College of Medicine, Rochester, MN 55905, USA
    J Thorac Cardiovasc Surg 129:767-72. 2005
    ..Hence the current study was designed to characterize and compare the structure of the adventitial vasa vasorum in the left internal thoracic and coronary arteries...
  69. ncbi request reprint Oxidative stress-related increase in ubiquitination in early coronary atherogenesis
    Joerg Hermann
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    FASEB J 17:1730-2. 2003
    ..These results demonstrate that the UPS is functionally active in early atherogenesis despite increase in oxidative stress with important repercussions in the pathophysiology and therapy of cardiovascular diseases...
  70. ncbi request reprint Hypercholesterolemia and hypertension have synergistic deleterious effects on coronary endothelial function
    Martin Rodriguez-Porcel
    Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic, 200 First St SW, Rochester, Minn 55905, USA
    Arterioscler Thromb Vasc Biol 23:885-91. 2003
    ..However, pathogenic mechanisms are poorly understood. Here we studied the effects of coexisting HC and HT on coronary endothelial function...
  71. ncbi request reprint Coronary endothelial dysfunction is associated with an increased risk of cerebrovascular events
    Paul V Targonski
    Division of Community Internal Medicine, Mayo Clinic and Foundation, Rochester, Minn 55905, USA
    Circulation 107:2805-9. 2003
    ..However, the magnitude of the association between coronary endothelial dysfunction (CED) and cerebrovascular events is unknown. This study was performed to investigate the association between CED and cerebrovascular events...
  72. ncbi request reprint Women's Ischemic Syndrome Evaluation: current status and future research directions: report of the National Heart, Lung and Blood Institute workshop: October 2-4, 2002: Section 2: stable ischemia: pathophysiology and gender differences
    Rita F Redberg
    Circulation 109:e47-9. 2004
  73. ncbi request reprint Endothelial dysfunction: a marker of atherosclerotic risk
    Piero O Bonetti
    Center for Coronary Physiology and Imaging, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Arterioscler Thromb Vasc Biol 23:168-75. 2003
    ....
  74. ncbi request reprint Preprocedural statin medication reduces the extent of periprocedural non-Q-wave myocardial infarction
    Joerg Herrmann
    Department of Cardiology, University Clinic Essen, Essen, Germany
    Circulation 106:2180-3. 2002
    ..Thus, we tested the hypothesis that preprocedural statin therapy is associated with a reduction in the extent of stenting-related myocardial injury...
  75. ncbi request reprint c-Myc oncoprotein: cell cycle-related events and new therapeutic challenges in cancer and cardiovascular diseases
    Filomena de Nigris
    Department of Pharmacological Sciences, University of Salerno, Salerno, Italy
    Cell Cycle 2:325-8. 2003
    ..In general, the increased biologic understanding of the participation of cell cycle events and targeting these events may enable to attenuate or prevent some of the complications of vascular and neoplastic diseases...
  76. ncbi request reprint Successful treatment of symptomatic coronary endothelial dysfunction with enhanced external counterpulsation
    Piero O Bonetti
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Mayo Clin Proc 79:690-2. 2004
    ....
  77. ncbi request reprint Consensus panel recommendation for incorporating lipoprotein-associated phospholipase A2 testing into cardiovascular disease risk assessment guidelines
    Michael H Davidson
    Preventive Cardiology Center, Pritzker School of Medicine, University of Chicago, 515 North State Street, Chicago, IL 60610, USA
    Am J Cardiol 101:51F-57F. 2008
    ..However, at this time Lp-PLA(2) cannot be recommended as a target of therapy...
  78. ncbi request reprint Myocardial perfusion in apical ballooning syndrome correlate of myocardial injury
    Ahmad Elesber
    Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Am Heart J 152:469.e9-13. 2006
    ..This study evaluated myocardial perfusion abnormalities at the time of presentation in patients with ABS and examined whether abnormal microvascular blood flow predicts the extent of myocardial injury...
  79. ncbi request reprint Pregnancy associated plasma protein-A and risk stratification of patients presenting with chest pain in the emergency department
    Ahmad A Elesber
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Int J Cardiol 117:365-9. 2007
    ....
  80. ncbi request reprint Plasma 8-iso-prostaglandin F2alpha, a marker of oxidative stress, is increased in patients with acute myocardial infarction
    Ahmad A Elesber
    The Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Free Radic Res 40:385-91. 2006
    ..The aim of our study is to examine whether the plasma 8-iso-prostaglandin F(2alpha) level, a marker of oxidative stress, is elevated in patients with acute myocardial infarction...
  81. ncbi request reprint Variable response of conductance and resistance coronary arteries to endothelial stimulation in patients with heart failure due to nonischemic dilated cardiomyopathy
    Fahed Bitar
    Heart Failure Program, Division of Cardiovascular Medicine, University of Southern California, Keck School of Medicine, Los Angeles, California, USA
    J Cardiovasc Pharmacol Ther 11:197-202. 2006
    ..Abnormal endothelial response of coronary blood flow to acetylcholine could not be predicted by demographic and hemodynamic data...
  82. ncbi request reprint Management of the patient with chest pain and a normal coronary angiogram
    Eric H Yang
    The Center of Coronary Physiology and Imaging, Division of Cardiovascular Diseases, Mayo College of Medicine, Rochester, MN 55905, USA
    Cardiol Clin 23:559-68, viii. 2005
  83. ncbi request reprint Systemic inflammation and metabolic syndrome in cardiac allograft vasculopathy
    Eugenia R Raichlin
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Heart Lung Transplant 26:826-33. 2007
    ..We investigated the role of insulin resistance and C-reactive protein (CRP) in predicting development of angiographic cardiac allograft vasculopathy (CAV)...
  84. ncbi request reprint The effect of drug eluting stents on cardiovascular events in patients with intermediate lesions and borderline fractional flow reserve
    Shahar Lavi
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Catheter Cardiovasc Interv 70:525-31. 2007
    ..To assess the role of fractional flow reserve (FFR) in guiding therapy in the drug eluting stent (DES) era...
  85. ncbi request reprint IAGS proceedings. The biology of plaque and patient vulnerability. Panel discussion
    Amir Lerman
    J Invasive Cardiol 17:239-42. 2005
  86. ncbi request reprint Lipoprotein-associated phospholipase A2 predicts progression of cardiac allograft vasculopathy and increased risk of cardiovascular events in heart transplant patients
    Eugenia Raichlin
    William J von Liebig Transplant Center, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Transplantation 85:963-8. 2008
    ..We evaluated the association between Lp-PLA2, cardiac allograft vasculopathy (CAV) assessed by 3D intravascular ultrasound, and incidence of cardiac adverse events in heart transplant recipients...
  87. ncbi request reprint Role of lipoprotein-associated phospholipase A2 in atherosclerosis
    Shahar Lavi
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Curr Atheroscler Rep 10:230-5. 2008
    ..In addition to being a useful marker of a risk factor, several studies suggest that Lp-PLA(2) has a pathophysiologic role in the atherosclerotic disease process. In this article, we review this aspect and its therapeutic implications...
  88. ncbi request reprint Physiological assessment of coronary artery disease in the cardiac catheterization laboratory: a scientific statement from the American Heart Association Committee on Diagnostic and Interventional Cardiac Catheterization, Council on Clinical Cardiology
    Morton J Kern
    University of California, Irvine, USA
    Circulation 114:1321-41. 2006
    ..The goal of this statement is to provide a logical approach to the use of coronary physiological measurements in the catheterization lab to assist both clinicians and investigators in improving patient care...
  89. ncbi request reprint Effect of long-term hormone replacement therapy on coronary endothelial function in postmenopausal women
    Sean C Halligan
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Mayo Clin Proc 79:1514-20. 2004
    ..To determine the difference in endothelial function between premenopausal and postmenopausal women and to determine whether hormone replacement therapy (HRT) is associated with an improvement in coronary endothelial function...
  90. ncbi request reprint Rethinking primary prevention of atherosclerosis-related diseases
    Claudio Napoli
    Department of General Pathology and Excellence Research Center on Cardiovascular Diseases, 1st School of Medicine, II University of Naples, Complesso S Andrea delle Dame, Naples 80134, Italy
    Circulation 114:2517-27. 2006

Research Grants8

  1. ENDOTHELIN IN HUMANS CORONARY IN EARLY ATHEROSCLEROSIS
    Amir Lerman; Fiscal Year: 2000
    ....
  2. ENDOTHELIN IN HUMANS CORONARY IN EARLY ATHEROSCLEROSIS
    Amir Lerman; Fiscal Year: 2001
    ....
  3. ENDOTHELIN IN HUMANS CORONARY IN EARLY ATHEROSCLEROSIS
    Amir Lerman; Fiscal Year: 2002
    ....
  4. ENDOTHELIN IN HUMANS CORONARY IN EARLY ATHEROSCLEROSIS
    Amir Lerman; Fiscal Year: 2003
    ....
  5. Coronary Endothelial Function in Humans
    Amir Lerman; Fiscal Year: 2006
    ..The success of this program has the potential to further both the research and mentoring endeavors of patient-oriented investigation and mentoring the next generation of patient-oriented researchers. ..
  6. Lp-PLA2 and Coronary Atherosclerosis in Humans
    Amir Lerman; Fiscal Year: 2009
    ..One of the reasons is the process of inflammation in the wall of the vessel. The current application is focused on new methods to identify and treat this early process and potential prevents heart attacks and sudden death. ..
  7. Role of Endothelial Progenitor Cells in vascular Aging and Calcification
    AMIR contact LERMAN; Fiscal Year: 2010
    ....
  8. Lp-PLA2 and Coronary Atherosclerosis in Humans
    Amir Lerman; Fiscal Year: 2010
    ..One of the reasons is the process of inflammation in the wall of the vessel. The current application is focused on new methods to identify and treat this early process and potential prevents heart attacks and sudden death. ..