Research Topics
| Vanda LennonSummaryAffiliation: Mayo Clinic Country: USA Publications
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Detail Information
Publications
IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channelVanda A Lennon
Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
J Exp Med 202:473-7. 2005..NMO may represent the first example of a novel class of autoimmune channelopathy...
A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosisVanda A Lennon
Department of Neurology, Mayo Clinic Rochester, Rochester, MN 55905, USA
Lancet 364:2106-12. 2004..We assessed the capacity of a putative marker for neuromyelitis optica (NMO-IgG) to distinguish neuromyelitis optica and related disorders from multiple sclerosis...- Immunization with neuronal nicotinic acetylcholine receptor induces neurological autoimmune diseaseVanda A Lennon
Department of Immunology, Mayo Graduate and Medical Schools and Mayo Clinic, Rochester, Minnesota 55905, USA
J Clin Invest 111:907-13. 2003.... - Paraneoplastic autoimmune optic neuritis with retinitis defined by CRMP-5-IgGShelley A Cross
Department of Neurology, Mayo Graduate and Medical Schools, Mayo Clinic, Rochester, MN 55905, USA
Ann Neurol 54:38-50. 2003..Positive serology obviates the need for vitreous biopsy and expedites the search for cancer... 
Aquaporin-4 autoantibodies in a paraneoplastic contextSean J Pittock
Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Arch Neurol 65:629-32. 2008..Its antigen is the astrocytic water channel aquaporin-4; NMO-IgG has not been described in a cancer context...- Paraneoplastic antibodies coexist and predict cancer, not neurological syndromeSean J Pittock
Neurology, Mayo Clinic, Rochester, MN 55905, USA
Ann Neurol 56:715-9. 2004..The autoantibody profiles observed in patients with paraneoplastic disorders imply the targeting of multiple onconeural antigens and predict the patient's neoplasm, but not a specific neurological syndrome... - Pattern-specific loss of aquaporin-4 immunoreactivity distinguishes neuromyelitis optica from multiple sclerosisShanu F Roemer
Department of Neurology, Mayo Clinic, College of Medicine, 200 First St SW, Rochester, MN 55905, USA
Brain 130:1194-205. 2007..These findings strongly support a role for a complement activating AQP4-specific autoantibody as the initiator of the NMO lesion, and further distinguish NMO from MS... - Neuromyelitis optica and non organ-specific autoimmunitySean J Pittock
Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
Arch Neurol 65:78-83. 2008..Neuromyelitis optica (NMO) is often associated with other clinical or serological markers of non-organ-specific autoimmunity... - Autoantibody profiles and neurological correlations of thymomaSteven Vernino
Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
Clin Cancer Res 10:7270-5. 2004..Serological evaluation of a patient's profile of neuronal and muscle autoantibodies may aid in preoperative identification of an indeterminate mediastinal mass... - Ganglionic acetylcholine receptor autoantibody: oncological, neurological, and serological accompanimentsAndrew McKeon
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
Arch Neurol 66:735-41. 2009..To describe the clinical utility of the nicotinic ganglionic acetylcholine receptor (alpha3-AChR) autoantibody as a marker of neurological autoimmunity and cancer... - Coexistence of myasthenia gravis and serological markers of neurological autoimmunity in neuromyelitis opticaAndrew McKeon
Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
Muscle Nerve 39:87-90. 2009..0001. The coexistence of NMO and MG should be considered in atypical or refractory presentations of either disorder... - Serologic profiles aiding the diagnosis of autoimmune gastrointestinal dysmotilityRadhika Dhamija
Department of Immunology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Clin Gastroenterol Hepatol 6:988-92. 2008..Here we report 24 Mayo Clinic patients in whom the profile of serum autoantibodies aided this diagnosis... - Amphiphysin autoimmunity: paraneoplastic accompanimentsSean J Pittock
Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Ann Neurol 58:96-107. 2005..01). Overall, a minority of women (39%) and men (12%) had stiff-man phenomena. Only 10% of women (some with lung carcinoma) and 4% of men fulfilled diagnostic criteria for stiff-man syndrome... - Voltage-gated potassium channel autoimmunity mimicking creutzfeldt-jakob diseaseMichael D Geschwind
Neuroimmunology Laboratory, Hilton 3 78F, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
Arch Neurol 65:1341-6. 2008..Rapidly progressive dementia has a variety of causes, including Creutzfeldt-Jakob disease (CJD) and neuronal voltage-gated potassium channel (VGKC) autoantibody-associated encephalopathy... - Eliminating false-positive results in serum tests for neuromuscular autoimmunityMetha Apiwattanakul
Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
Muscle Nerve 41:702-4. 2010..05% and 1.7% for AchR and VGKC autoantibodies, respectively. Specificity assurance in radioimmunoprecipitation assays requires subtraction of values for 125I-ligand binding... - Frequency of seronegativity in adult-acquired generalized myasthenia gravisKoon Ho Chan
Department of Laboratory Medicine and Pathology, Mayo Clinic, College of Medicine, 200 First Street S W, Rochester, Minnesota 55905, USA
Muscle Nerve 36:651-8. 2007..Classification as seronegative MG should be reserved for nonimmunosuppressed patients with generalized MG who lack muscle AChR binding, AChR modulating, or MuSK antibodies at presentation and at follow-up of at least 12 months... - Neuromyelitis optica IgG serostatus in fulminant central nervous system inflammatory demyelinating diseaseSetty M Magaña
Department of Neurology, Mayo Clinic College of Medicine, 200 First Ave SW, Rochester, MN 55902, USA
Arch Neurol 66:964-6. 2009..To our knowledge, this study is the first to compare NMO IgG serostatus among patients with fulminant central nervous system inflammatory demyelinating disease (CNS IDD)... - Metastatic chondroblastoma with elevated creatine kinase and paraneoplastic neurologic autoimmunityDivya-Devi Joshi
Division of Pediatric Hematology/Oncology, Mayo Clinic Rochester, Minnesota 55905, USA
J Pediatr Hematol Oncol 25:900-4. 2003..The association of metastatic chondroblastoma, elevated CK, and an evolving profile of paraneoplastic autoantibodies reveals a previously unrecognized immunobiologic dimension of chondroblastoma... - Reversible extralimbic paraneoplastic encephalopathies with large abnormalities on magnetic resonance imagesAndrew McKeon
Department of Neurology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
Arch Neurol 66:268-71. 2009..To describe reversible extralimbic paraneoplastic encephalopathies with large, lobar lesions on magnetic resonance imaging (MRI)... - The spectrum of autoimmune autonomic neuropathiesCaroline M Klein
Department of Neurology, Medical University of South Carolina, Charleston, SC, USA
Ann Neurol 53:752-8. 2003.... - The spectrum of neuromyelitis opticaDean M Wingerchuk
Department of Neurology, Mayo Clinic College of Medicine, Scottsdale, AZ 85259, USA
Lancet Neurol 6:805-15. 2007..The knowledge gained from further assessment of the exact role of NMO-IgG in the pathogenesis of neuromyelitis optica will provide a foundation for rational therapeutic trials for this rapidly disabling disease... - Whole-body tremulousness: isolated generalized polymyoclonusAndrew McKeon
Department of Neurology, Gonda 8 South, Mayo Clinic, 200 First St SW, Rochester, MN 55902, USA
Arch Neurol 64:1318-22. 2007..Acquired generalized repetitive myoclonus may be mistaken for tremor. Distinguishing myoclonus has etiologic and therapeutic implications... - Autoimmune myelopathy associated with collapsin response-mediator protein-5 immunoglobulin GB Mark Keegan
Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Ann Neurol 63:531-4. 2008..Collapsin response-mediator protein-5 autoimmune myelopathy and occult neoplasia are important considerations in patients with insidiously progressive myelopathy, especially with known cancer risk... - Paraneoplastic jaw dystonia and laryngospasm with antineuronal nuclear autoantibody type 2 (anti-Ri)Sean J Pittock
Mayo Medical School College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
Arch Neurol 67:1109-15. 2010..However, the neurologic spectrum of ANNA-2 autoimmunity is broader, includes a syndrome of jaw dystonia and laryngospasm, and can be accompanied by lung carcinoma... - Aquaporin-4-binding autoantibodies in patients with neuromyelitis optica impair glutamate transport by down-regulating EAAT2Shannon R Hinson
Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
J Exp Med 205:2473-81. 2008..Thus, binding of NMO-IgG to astrocytic AQP4 initiates several potentially neuropathogenic mechanisms: complement activation, AQP4 and EAAT2 down-regulation, and disruption of glutamate homeostasis... - Diagnosis of neuromyelitis spectrum disorders: comparative sensitivities and specificities of immunohistochemical and immunoprecipitation assaysAndrew McKeon
Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Arch Neurol 66:1134-8. 2009.... - Peripherin-IgG association with neurologic and endocrine autoimmunityJayne L Chamberlain
Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
J Autoimmun 34:469-77. 2010..It remains to be determined whether or not peripherin-IgG is predictive for development of small fiber neuropathy (autonomic or somatic)... - NMO-IgG: a specific biomarker for neuromyelitis opticaBrian G Weinshenker
Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Dis Markers 22:197-206. 2006.... - Glutamic acid decarboxylase autoimmunity with brainstem, extrapyramidal, and spinal cord dysfunctionSean J Pittock
Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Mayo Clin Proc 81:1207-14. 2006..To describe novel neurological manifestations associated with glutamic acid decarboxylase (GAD65) autoimmunity... - Prediction of neuromyelitis optica attack severity by quantitation of complement-mediated injury to aquaporin-4-expressing cellsShannon R Hinson
Department of Laboratory Medicine and Pathology, Hilton 3 78D, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Arch Neurol 66:1164-7. 2009..The NMO-IgG binds in vitro to the extracellular domain of AQP4, activates complement, and causes astrocyte lesioning... - Ion channel and striational antibodies define a continuum of autoimmune neuromuscular hyperexcitabilitySteven Vernino
Department of Neurology, Mayo Clinic and Mayo Foundation, 200 First Street S W, Rochester, Minnesota 55905, USA
Muscle Nerve 26:702-7. 2002..We conclude that acquired neuromuscular hyperexcitability consists of a continuum of clinical disorders with a common autoimmune pathogenesis... - Neuronal ganglionic acetylcholine receptor autoimmunitySteven Vernino
Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
Ann N Y Acad Sci 998:211-4. 2003..These patients often have a high antibody value (>0.2 nmol/L). Lower values (0.05-0.20 nmol/L) are found in approximately 10% of patients with limited AAN... - ACh receptor protein drives primary and memory autoantibody responses in chimeric human-SCID miceHiroaki Yoshikawa
Department of Immunology, Mayo Graduate School and Medical School, Mayo Clinic, Rochester, MN 55905, USA
Clin Immunol 104:128-37. 2002..In healthy subjects, AChR-specific lymphocytes are infrequent and exhibit naive response characteristics, including apparent affinity maturation of Ig specificity... - Passive transfer of autoimmune autonomic neuropathy to miceSteven Vernino
Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
J Neurosci 24:7037-42. 2004..The antibody effect is potentially reversible, justifying early use of immunomodulatory therapy directed at lowering IgG levels and abrogating IgG production in patients with AAN... - Neuromyelitis optica IgG predicts relapse after longitudinally extensive transverse myelitisBrian G Weinshenker
Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Ann Neurol 59:566-9. 2006..We investigated whether neuromyelitis optica (NMO) IgG seropositivity at the initial presentation of longitudinally extensive transverse myelitis (LETM) predicts relapse of myelitis or development of optic neuritis... - Paraneoplastic chorea associated with CRMP-5 neuronal antibody and lung carcinomaSteven Vernino
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
Ann Neurol 51:625-30. 2002..Four patients improved with chemotherapy, and 2 improved with intravenous methylprednisolone... - Muscle and neuronal autoantibody markers of thymoma: neurological correlationsSteven Vernino
Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
Ann N Y Acad Sci 998:359-61. 2003 - Neuromyelitis optica brain lesions localized at sites of high aquaporin 4 expressionSean J Pittock
Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905 0001, USA
Arch Neurol 63:964-8. 2006..Although it is conventionally believed that the brain is spared, brain imaging abnormalities are not uncommon in patients with NMO... - Anti-neuronal nuclear autoantibody type 2: paraneoplastic accompanimentsSean J Pittock
Department of Neurology, Mayo Graduate and Medical Schools, Mayo Clinic, Rochester, MN 55905, USA
Ann Neurol 53:580-7. 2003.... - Paraneoplastic dysmotility: loss of interstitial cells of CajalDarrell S Pardi
Department of Physiology and Biophysics, Mayo Clinic, Rochester, Minnesota 55905, USA
Am J Gastroenterol 97:1828-33. 2002..The histopathology of this case suggests that interstitial cells of Cajal may be a target in the pathogenesis of paraneoplastic motility disorders... - Paraneoplastic neurological autoimmunity associated with ANNA-1 autoantibody and thymomaSteven Vernino
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
Neurology 59:929-32. 2002..Retrospective testing of stored serum from 172 patients with thymoma revealed ANNA-1 in 3%. This report extends the oncologic implications of ANNA-1 seropositivity... - Neural autoantibody profile of primary achalasiaRobert E Kraichely
Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Dig Dis Sci 55:307-11. 2010..5% in control subjects), in the absence of diabetes or companion antibodies predictive of type 1 diabetes. This profile of autoantibodies suggests an autoimmune basis for a subset of primary achalasia... - Autoimmune gastrointestinal dysmotility treated successfully with pyridostigmineShabana F Pasha
Department of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Scottsdale, Arizona, USA
Gastroenterology 131:1592-6. 2006..Certain neuronal nuclear and cytoplasmic autoantibodies are highly predictive of an underlying malignancy... - Experimental autoimmune autonomic neuropathySteven Vernino
Department of Neurology, Mayo Graduate and Medical Schools, Mayo Clinic, Rochester, Minnesota 55905, USA
J Neurophysiol 90:2053-9. 2003..These findings define the autonomic physiology and histopathology of this novel animal model and support the concept that AAN in humans is a disorder of ganglionic cholinergic synaptic transmission caused by ganglionic nAChR antibodies... - Brain abnormalities in neuromyelitis opticaSean J Pittock
Department of Neurology, Laboratory Medicine and Pathology, Radiology, and Immunology, Mayo Clinic College of Medicine, Rochester, Minn, USA
Arch Neurol 63:390-6. 2006..CONCLUSIONS: Asymptomatic brain lesions are common in NMO, and symptomatic brain lesions do not exclude the diagnosis of NMO. These observations justify revision of diagnostic criteria for NMO to allow for brain involvement... - Idiopathic autonomic neuropathy: comparison of cases seropositive and seronegative for ganglionic acetylcholine receptor antibodyPaola Sandroni
Department of Neurology, Mayo Foundation, Guggenheim 811, 200 First Street SW, Rochester, MN 55905, USA
Arch Neurol 61:44-8. 2004..Patients with orthostatic hypotension and prominent cholinergic dysautonomia are most likely to be seropositive for ganglionic AChR antibody... - Paraneoplastic movement disorder in a patient with non-Hodgkin's lymphoma and CRMP-5 autoantibodyAli Samii
Department of Neurology, University of Washington School of Medicine, Seattle, Washington, USA
Mov Disord 18:1556-8. 2003..We report on details of a movement disorder that followed anti-B-cell therapy in a patient with lymphoma, and was accompanied by CRMP-5 IgG... - Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasionHaidong Dong
Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA
Nat Med 8:793-800. 2002..These findings have implications for the design of T cell-based cancer immunotherapy... - Postural orthostatic tachycardia syndrome: the Mayo clinic experienceMark J Thieben
Autonomic Disorders Center, Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
Mayo Clin Proc 82:308-13. 2007..To evaluate the prevalence and pathogenetic mechanisms of postural orthostatic tachycardia syndrome (POTS)... - Positron emission tomography-computed tomography in paraneoplastic neurologic disorders: systematic analysis and reviewAndrew McKeon
Department of Neurology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
Arch Neurol 67:322-9. 2010..To evaluate the cancer detection rate of whole-body positron emission tomography-computed tomography (PET-CT) in a paraneoplastic neurologic context... - An outbreak of neurological autoimmunity with polyradiculoneuropathy in workers exposed to aerosolised porcine neural tissue: a descriptive studyDaniel H LaChance
Department of Neurology, Mayo Clinic, Rochester, MN, USA Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
Lancet Neurol 9:55-66. 2010..We aimed to describe the pathogenic and immunological characteristics of this illness... - Intractable vomiting as the initial presentation of neuromyelitis opticaMetha Apiwattanakul
Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Ann Neurol 68:757-61. 2010..Our clinical, pathologic and neuroimaging observations suggest the aquaporin-4-rich area postrema may be a first point of attack in neuromyelitis optica... - Autoimmune dementia: clinical course and predictors of immunotherapy responseEoin P Flanagan
Department of Neurology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
Mayo Clin Proc 85:881-97. 2010..To define the diagnostic characteristics and predictors of treatment response in patients with suspected autoimmune dementia... - OSMS is NMO, but not MS: proven clinically and pathologicallyBrian G Weinshenker
Lancet Neurol 5:110-1. 2006 - Autoimmune autonomic neuropathy. An immunopharmacological diseaseVanda A Lennon
Clin Auton Res 12:225-7. 2002 - Do calcium channel autoantibodies cause cerebellar ataxia with Lambert-Eaton syndrome?Colin F Fletcher
Ann Neurol 53:5-7. 2003
Research Grants
- Spectrum of Autoimmune Gastrointestinal DysmotilityVanda Lennon; Fiscal Year: 2009..l.dysmotilities, and justify early consideration of immunomodulatory therapies. The proposed research also has high clinical relevance to cancer immunity. ..