Bradley C Leibovich

..We established long-term survival in patients following partial nephrectomy according to tumor size...

..Herein, we discuss the role of surgery for the management of localized and metastatic RCC...

..We evaluated the association of tumor thrombus level and fat invasion with outcome to determine if further subclassification would improve the prognostic accuracy of the current classification...

..We compared outcomes between patients treated with nephron sparing surgery (NSS) without imperative indications for renal preservation and radical nephrectomy (RN) for 4 to 7 cm renal cell carcinoma (RCC)...

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..We examined the significance of histological subtype on progression to distant metastasis and cancer specific death after nephrectomy...

..We developed a clinically useful scoring algorithm to predict cancer specific survival for patients with clear cell metastatic renal cell carcinoma (RCC)...

..The authors surmised that B7-H1 blockade may augment current immunotherapy, including patients treated for metastases after cytoreductive nephrectomy...

..The net result is a dynamic tool that renders clinically relevant predictions that change as the patient's clinical status changes throughout the postoperative course...

..The indications for the removal of the ipsilateral adrenal gland in patients with renal cell carcinoma (RCC) and the long-term outcomes have not been well studied...

..35-9.15; P = 0.010). Tumor-associated B7-H1 expression is significantly associated with poor prognosis among patients with clear-cell RCC. Manipulation of B7-H1 with therapeutic intent remains a realistic and viable therapeutic option...

..However, after prostatectomy, BMI does not appear to be an independent predictor of recurrence or survival...

..61 vs. 0.55, respectively). CONCLUSIONS: Direct adrenal invasion from RCC should be reclassified as pT4. In addition, the proposed reclassification for patients with pT3 RCC improved prognostic accuracy...

..As such, we evaluated the association of B7-H3 expression with clinicopathologic outcomes in patients treated for ccRCC...

..A chronological change in pathologic grading classification is suggested by evolving prognostic implications, which must be accounted for when comparing outcomes from different eras...

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..Herein, we examine the clinical effect of ccRCC combined expression of both survivin and B7-H1...

..The authors present a scoring algorithm based on these features that can be used to predict survival in patients who present with metastatic RCC and to stratify such patients for prospective clinical trials...

..To evaluate the effects of warm ischemia time (WIT) and quantity and quality of kidney preserved on renal functional recovery after partial nephrectomy (PN). The effect of WIT relative to these other parameters has recently been challenged...

..We attempted to validate the prognostic utility of CAIX expression using a large cohort of ccRCC patients with long-term follow-up...

..What remained in question was whether survivin expression at the protein level is an independent predictor of disease progression and cancer-specific survival...

..RCC patients with tumor B7-H1 are at significant risk of rapid cancer progression and accelerated rates of mortality. B7-H1 may function as a key determinant in RCC, abrogating immune responses directed against this immunogenic tumor...

..90; P < 0.001). CONCLUSIONS: Histologic coagulative tumor necrosis is an independent predictor of outcome for clear cell and chromophobe RCC, and it should be routinely reported and used in clinical assessment...

..In the current study, they described the creation of a scoring system based on this panel of biomarkers that can be used in tandem with existing clinicopathologic features and algorithms to improve ccRCC outcome prediction...

..61; P = .028). CONCLUSIONS: Mononuclear cell infiltration is associated with death from RCC even after multivariate adjustment. Routine documentation of mononuclear cell infiltration is recommended during the pathologic assessment of RCC...

..It was developed from patients who underwent radical retropubic prostatectomy from 1990 to 1993. We investigated the predictive ability of GPSM in the contemporary era...

..In the current study we evaluated the 2002 primary tumor classification and compared its predictive ability with that of the 1997 classification...

..To determine whether iatrogenic immunosuppression used after transplantation infers a poor prognosis of renal cell carcinoma (RCC) as natural negative immune regulators have been associated with decreased cancer-specific survival from RCC...

..Observational studies suggest a proportion of patients with lymph node metastases will benefit from lymph node dissection (LND) at the time of nephrectomy for clear cell renal cell carcinoma (RCC)...

..We investigated the prognostic significance of each of these pathological features using a cohort of pT3a patients...

..The authors evaluated the long-term outcomes of men with prostate cancer and very high (> or =50 ng/mL) preoperative serum prostate-specific antigen (PSA) values that were treated with radical prostatectomy...

..Last, we demonstrate that patients with RCC tumors expressing both B7-H4 and B7-H1 are at an even greater risk of death from RCC...

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..Thus, the goal was to directly test whether Ki-67 and necrosis convey similar or distinct information for the prognostic assessment of ccRCC...

..Appropriate assessment of nephrectomy specimens should include proper sampling of the renal sinus even for seemingly localized tumors...

..CONCLUSIONS: We present scoring algorithms based on multivariately significant predictors of site specific recurrence that can be used to tailor postoperative surveillance to the individual patient...

..We performed a systematic review and meta-analysis of partial vs radical nephrectomy for localized renal tumors, considering all cause and cancer specific mortality, and severe chronic kidney disease...

..Nodal status, cancer grade and PSADT are predictive of sRFS and CSS, and may be a useful means of selecting patients for future adjuvant therapy trials...

..We retrospectively determined the efficacy of percutaneous renal cryoablation based on a mean followup of more than 2 years...

..We surveyed American Urological Association members to determine factors that influence the treatment of patients with small renal masses...

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..To evaluate our single institution experience with percutaneous cryoablation of renal masses >or=3 cm in diameter for complications and short-term outcomes...

..In the current study we evaluated the association of direct ipsilateral adrenal invasion with outcome to determine if reclassification of these tumors as pT4 would improve the accuracy of the current tumor classification...

..For patients with clear cell RCC, the ESR provided useful information above and beyond traditional prognostic algorithms, and it may be valuable for preoperative prognostication...

..The objective of this study was to evaluate the accuracy of the pathologic inclusion criteria from all contemporary adjuvant trials in predicting disease progression (DP) for renal cell carcinoma (RCC)...

..To review complications related to percutaneous renal tumor ablation...

..To determine the metastatic potential of renal masses based on original tumour size...

..We describe the indications, technique, complications and outcomes of vena caval interruption during nephrectomy with tumor thrombectomy...

..The safe duration of warm ischemia during partial nephrectomy remains controversial...

..To determine whether preoperative laboratory values are independently associated with death from clinically confined clear cell renal cell carcinoma (RCC) after radical nephrectomy...

..The indications and results for venovenous bypass (VVB) versus cardiopulmonary bypass (CPB) were reviewed as well...

..As such, the authors review the current prognostic tools for predicting disease progression for localized RCC, and detail studies to date that have evaluated various biomarkers in this setting...

..Thus, visual assessment represents an economical, widely available, and reliable method to assess survivin as a predictor of clear cell renal cell carcinoma patient outcomes...

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..AML is a highly vascular tumor that most frequently emanates from the kidney. Events leading to its pathogenesis remain enigmatic and understudied...

..CONCLUSIONS: BMI offers little additional prognostic information beyond the accepted prognostic features; however, the association of an increased BMI with a less-aggressive disease profile at presentation warrants further exploration...

..We evaluated expression of the T-cell coregulators B7-H1, B7-H3, and PD-1 in urothelial cell carcinoma (UCC) of the bladder...

..Our data also indicate that the gene expression alterations that result in aggressive behavior and metastatic potential can be identified in the primary tumor...

..We reviewed our surgical experience with small renal tumors, comparing overall survival in patients treated with radical and partial nephrectomy...

..Levels of immune cells expressing PD-1 (PD-1(+)) in clinical RCC tumors have not been evaluated. Thus, we tested whether immune cell PD-1 expression is observed within aggressive RCC tumors...

..To characterize the incidence and clinicopathologic factors associated with late recurrence after surgical resection for renal cell carcinoma (RCC) because the recurrence patterns >5 years after nephrectomy have been poorly described...

..59; P = 0.010) and after adjusting for TNM stage, tumor size, and histologic tumor necrosis (risk ratio 1.46; P = 0.037)...

..We created a dynamic outcome prediction model for continual surveillance that accounts for the disease-free interval following surgery...

..We reviewed our experience with contemporary open NSS, comparing complication rates to those of historical controls and updating data for comparison with minimally invasive procedures...

..We investigated the association of perinephric and renal sinus fat invasion with death from renal cell carcinoma independent of tumor size...

..We tested for the presence of putative Tregs within renal cell carcinoma (RCC) tumors...

..To date, there are no molecular markers which can reliably predict RCC outcome. We investigated whether a novel kidney cancer marker, carbonic anhydrase IX (CAIX), is associated with progression and survival...

..This article examines the rationale for lymphadenectomy in the management of renal cell carcinoma and reviews the limited literature on the subject...

..Current data clearly support the use of elective NSS for localized solid renal masses under 4 cm in size...

..There was oncological success in a third of the patients. The treatment of these patients needs to be individualized, as alternatives to NSS (RN or observation) have obvious disadvantages...

..We examined the impact of seminomatous elements on the rate of complications and the need for additional intraoperative procedures in patients undergoing post-chemotherapy retroperitoneal lymph node dissection...

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..We reviewed our experience with radical retropubic prostatectomy in patients with solid organ transplants...

..To report the surgical management, complications and outcomes over three decades by tumour thrombus level for patients with renal cell carcinoma (RCC) and renal venous extension, as surgery is the most effective treatment...

..In this study we determined whether a size cutoff point exists within pT2 tumors and whether such subclassification would further improve the accuracy of the current tumor classification...

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..Results suggest a positive association of UTI history with RCC development, with elevated risks most notable for males with a history of smoking...

..Survival in patients with disease limited to the lung was similar to that of patients whose disease was limited to bone...

..The use of adjuvant radiation therapy following prostatectomy is commonplace. The purpose of this review is to summarize completed and ongoing clinical trials and to review recent relevant studies and debates related to this subject...

..The safe duration of warm ischemia during partial nephrectomy (PN) remains controversial...

..We retrospectively evaluated the accuracy of gadolinium enhanced magnetic resonance urography to detect upper urinary tract tumors...

..Sulfa therapy was begun. In previous case reports, this condition carried a 50% mortality rate. Patients who survive seemed to benefit from aggressive surgical debridement and long-term sulfa therapy...

..We determined technical feasibility, safety and short-term outcomes following percutaneous renal cryoablation...

..We report our experience with resection of isolated retroperitoneal lymph node recurrence...

..Studies have demonstrated increased time to progression when cytoreductive nephrectomy is performed for metastatic renal cell carcinoma. We evaluated the role of nephron sparing surgery in these patients...

..Controversy exists as to which form of therapy is most effective for high-grade prostate cancer (PCa)...

..In all, this article aims to give the reader a broad overview of the basic elements of prostate cancer diagnosis and surgical treatment in the modem era...

..Thus, it is possible that men with PD have been denied a potentially curative surgery only on the basis of long-standing assumptions. We addressed this issue by examining a cohort of men with PD who underwent RP at our institution...

..Recent data have suggested that somatic mutations of the VHL tumor suppressor gene are associated with better cancer-specific survival in patients with CC-RCC...

..Herein we review the relevance of these modalities to the follow-up of patients with renal cell carcinoma...

..To retrospectively determine the safety and effectiveness of percutaneous cryoablation, monitored with computed tomography (CT), for the treatment of solid renal masses...

..This retrospective study was performed to assess the feasibility, safety, and short-term outcome of percutaneous cryoablation of large solid renal tumors...

..While these data await external validation, consideration should be given to re-categorizing tumors with direct adrenal gland involvement as stage pT4 or in a subcategory such as pT4a...

..These factors likely contributed to improved cancer specific survival for younger patients...

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..However, long-term outcome data are lacking. We reviewed our experience with RCC and report on pathologic features and patient outcome associated with the cystic variant...