JAMES JOSEPH LEE

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells
    Elizabeth A Jacobsen
    Division of Pulmonary Medicine, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA
    J Exp Med 205:699-710. 2008
  2. pmc Homologous recombination into the eosinophil peroxidase locus generates a strain of mice expressing Cre recombinase exclusively in eosinophils
    Alfred D Doyle
    Division of Pulmonary Medicine, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, Arizona, USA
    J Leukoc Biol 94:17-24. 2013
  3. pmc Human versus mouse eosinophils: "that which we call an eosinophil, by any other name would stain as red"
    James J Lee
    Division of Pulmonary Medicine, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, AZ, USA
    J Allergy Clin Immunol 130:572-84. 2012
  4. pmc Immunodetection of occult eosinophils in lung tissue biopsies may help predict survival in acute lung injury
    Lian Willetts
    Division of Pulmonary Medicine, Department of Internal Medicine, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA
    Respir Res 12:116. 2011
  5. pmc Regulatory role of CD8+ T lymphocytes in bone marrow eosinophilopoiesis
    Madeleine Radinger
    Lung Pharmacology Group, Department of Internal Medicine Respiratory Medicine and Allergology, Goteborg University, Goteborg, Sweden
    Respir Res 7:83. 2006
  6. pmc The identification of eosinophilic gastroenteritis in prednisone-dependent eosinophilic bronchitis and asthma
    Parameswaran Nair
    Firestone Institute for Respiratory Health, St, Joseph s Healthcare and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Allergy Asthma Clin Immunol 7:4. 2011
  7. ncbi request reprint Defining a link with asthma in mice congenitally deficient in eosinophils
    James J Lee
    Division of Pulmonary Medicine, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA
    Science 305:1773-6. 2004
  8. pmc When is a mouse basophil not a basophil?
    James J Lee
    Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale 85259, and Animal Care and Technologies, Arizona State University, Tempe, USA
    Blood 109:859-61. 2007
  9. pmc Eosinophils in health and disease: the LIAR hypothesis
    J J Lee
    Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, 85259, USA
    Clin Exp Allergy 40:563-75. 2010
  10. ncbi request reprint A causative relationship exists between eosinophils and the development of allergic pulmonary pathologies in the mouse
    HuaHao H Shen
    Division of Hematology Oncology, Department of Biochemistry and Molecular Biology, Mayo Clinic Scottsdale, S C Johnson Medical Research Center, Scottsdale, AZ 85259, USA
    J Immunol 170:3296-305. 2003

Collaborators

  • Stephania A Cormier
  • Michael T Borchers
  • Jeffrey R Crosby
  • Michael R Blackburn
  • Lian Willetts
  • Paige Lacy
  • Charles Irvin
  • Steven Ackerman
  • Nancy A Lee
  • Sergei I Ochkur
  • Elizabeth A Jacobsen
  • Ralph S Pero
  • Michael P McGarry
  • Anna G Taranova
  • Cheryl A Protheroe
  • Dana C Colbert
  • Katie R O'Neill
  • Alfred D Doyle
  • Parameswaran Nair
  • J Paul Justice
  • HuaHao H Shen
  • Eva Morschl
  • Hiam Abdala-Valencia
  • Lutz Birnbaumer
  • Huahao Shen
  • Jose G Molina
  • Madeleine Radinger
  • Huiying Wang
  • Hays W J Young
  • Jake Kloeber
  • Joseph Neely
  • Kelly Shim
  • Redwan Moqbel
  • Will E Lesuer
  • Elizabeth Simms
  • Cheryl Protheroe
  • Farrah Kheradmand
  • Joan Cook-Mills
  • Clive S Grant
  • Alfred Doyle
  • Jeong Soo Hong
  • Jonathan B Volmer
  • Amir Mohsenin
  • Celine M Vachon
  • David Maldonado
  • Karsten Spicher
  • Travis L Biechele
  • Joan M Cook-Mills
  • P Sriramarao
  • Lyudmila Sikora
  • Savita P Rao
  • Melvin I Simon
  • Thomas V Colby
  • Margareta Sjöstrand
  • Jan Lotvall
  • Apostolos Bossios
  • Anna Karin Johansson
  • Carina Malmhäll
  • Svetlana Sergejeva
  • Dawn Dimina
  • Lee Nien L Chan
  • Marlene Jacobson
  • Hongyan Zhong
  • Teh Sheng Chan
  • Edie M Hines
  • Travis L Biechelle
  • Tracy L Ansay
  • Edith M Hines
  • Patricia J Ohtake
  • Edward K Novak
  • Richard T Swank

Detail Information

Publications24

  1. pmc Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells
    Elizabeth A Jacobsen
    Division of Pulmonary Medicine, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA
    J Exp Med 205:699-710. 2008
    ..In summary, the data suggest that pulmonary eosinophils are required for the localized recruitment of effector T cells...
  2. pmc Homologous recombination into the eosinophil peroxidase locus generates a strain of mice expressing Cre recombinase exclusively in eosinophils
    Alfred D Doyle
    Division of Pulmonary Medicine, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, Arizona, USA
    J Leukoc Biol 94:17-24. 2013
    ....
  3. pmc Human versus mouse eosinophils: "that which we call an eosinophil, by any other name would stain as red"
    James J Lee
    Division of Pulmonary Medicine, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, AZ, USA
    J Allergy Clin Immunol 130:572-84. 2012
    ....
  4. pmc Immunodetection of occult eosinophils in lung tissue biopsies may help predict survival in acute lung injury
    Lian Willetts
    Division of Pulmonary Medicine, Department of Internal Medicine, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA
    Respir Res 12:116. 2011
    ..We hypothesized that occult eosinophilic pneumonia may explain better outcomes for some patients with ALI...
  5. pmc Regulatory role of CD8+ T lymphocytes in bone marrow eosinophilopoiesis
    Madeleine Radinger
    Lung Pharmacology Group, Department of Internal Medicine Respiratory Medicine and Allergology, Goteborg University, Goteborg, Sweden
    Respir Res 7:83. 2006
    ..Since bone marrow (BM) responses are intricately involved in the induction of airway eosinophilia, we hypothesized that CD8+ T lymphocytes, as well as CD4+ T lymphocytes, may be involved in this process...
  6. pmc The identification of eosinophilic gastroenteritis in prednisone-dependent eosinophilic bronchitis and asthma
    Parameswaran Nair
    Firestone Institute for Respiratory Health, St, Joseph s Healthcare and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Allergy Asthma Clin Immunol 7:4. 2011
    ....
  7. ncbi request reprint Defining a link with asthma in mice congenitally deficient in eosinophils
    James J Lee
    Division of Pulmonary Medicine, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA
    Science 305:1773-6. 2004
    ..The development of an eosinophil-less mouse now permits an unambiguous assessment of a number of human diseases that have been linked to this granulocyte, including allergic diseases, parasite infections, and tumorigenesis...
  8. pmc When is a mouse basophil not a basophil?
    James J Lee
    Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale 85259, and Animal Care and Technologies, Arizona State University, Tempe, USA
    Blood 109:859-61. 2007
    ....
  9. pmc Eosinophils in health and disease: the LIAR hypothesis
    J J Lee
    Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, 85259, USA
    Clin Exp Allergy 40:563-75. 2010
    ..Our hope is to create more questions than we answer and provoke everyone to spend countless hours simply to prove us wrong!..
  10. ncbi request reprint A causative relationship exists between eosinophils and the development of allergic pulmonary pathologies in the mouse
    HuaHao H Shen
    Division of Hematology Oncology, Department of Biochemistry and Molecular Biology, Mayo Clinic Scottsdale, S C Johnson Medical Research Center, Scottsdale, AZ 85259, USA
    J Immunol 170:3296-305. 2003
    ..These data support an expanded view of T cell and eosinophil activities and suggest that eosinophil effector functions impinge directly on lung function...
  11. ncbi request reprint Coexpression of IL-5 and eotaxin-2 in mice creates an eosinophil-dependent model of respiratory inflammation with characteristics of severe asthma
    Sergei I Ochkur
    Division of Pulmonary Medicine, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA
    J Immunol 178:7879-89. 2007
    ..Genetic ablation of all eosinophils from this double transgenic model abolished the induced pulmonary pathologies, demonstrating that these pathologies are a consequence of one or more eosinophil effector functions...
  12. ncbi request reprint Ablation of eosinophils leads to a reduction of allergen-induced pulmonary pathology
    J Paul Justice
    Division of Hematology Oncology and Pulmonary Medicine, Department of Biochemistry and Molecular Biology, S C Johnson Medical Research Building, Mayo Clinic Scottsdale, 13400 E Shea Boulevard, Scottsdale, AZ 85259, USA
    Am J Physiol Lung Cell Mol Physiol 284:L169-78. 2003
    ..These data demonstrate a direct causative relationship between allergen-mediated pulmonary pathologies and eosinophils...
  13. pmc Galphai2-mediated signaling events in the endothelium are involved in controlling leukocyte extravasation
    Ralph S Pero
    Division of Hematology Oncology, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA
    Proc Natl Acad Sci U S A 104:4371-6. 2007
    ..Collectively, these data suggest that specific Galpha(i2)-mediated signaling between endothelial cells and leukocytes is required for the extravasation of leukocytes and for tissue-specific accumulation...
  14. ncbi request reprint Gq signaling is required for allergen-induced pulmonary eosinophilia
    Michael T Borchers
    Division of Pulmonary Medicine, Mayo Clinic, Scottsdale AZ 85259, USA
    J Immunol 168:3543-9. 2002
    ....
  15. ncbi request reprint T(H)2-mediated pulmonary inflammation leads to the differential expression of ribonuclease genes by alveolar macrophages
    Stephania A Cormier
    Divisions of Hematology Oncology and Pulmonary Medicine, Department of Biochemistry and Molecular Biology, Mayo Clinic Scottsdale, S C Johnson Medical Research Center, Scottsdale, Arizona 85259, USA
    Am J Respir Cell Mol Biol 27:678-87. 2002
    ....
  16. ncbi request reprint Early phase bronchoconstriction in the mouse requires allergen-specific IgG
    Jeffrey R Crosby
    Divisions of Hematology Oncology and Pulmonary Medicine, Department of Biochemistry and Molecular Biology, Mayo Clinic Scottsdale, Scottsdale, AZ 85259, USA
    J Immunol 168:4050-4. 2002
    ..Thus, in the mouse the initial period of bronchoconstriction following allergen exposure may involve neither mast cells nor IgE-mediated events...
  17. pmc Allergic pulmonary inflammation promotes the recruitment of circulating tumor cells to the lung
    Anna G Taranova
    Department of Biochemistry and Molecular Biology, Divisions of Pulmonary Medicine, Mayo Clinic Arizona, Scottsdale, Arizona 85259, USA
    Cancer Res 68:8582-9. 2008
    ....
  18. pmc A3 adenosine receptor signaling influences pulmonary inflammation and fibrosis
    Eva Morschl
    Department of Biochemistry and Molecular Biology, University of Texas Health Science Center at Houston, Medical School, Houston, Texas77030, USA
    Am J Respir Cell Mol Biol 39:697-705. 2008
    ..Together, these results suggest that the A(3)R serves antiinflammatory functions in the bleomycin model, and is also involved in regulating the production of mediators that can impact fibrosis...
  19. ncbi request reprint A3 adenosine receptor signaling contributes to airway inflammation and mucus production in adenosine deaminase-deficient mice
    Hays W J Young
    Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, Houston, TX 77030, USA
    J Immunol 173:1380-9. 2004
    ..These findings identify an important role for the A(3)R in regulating lung eosinophilia and mucus production in an environment of elevated adenosine...
  20. pmc Pivotal Advance: eosinophil infiltration of solid tumors is an early and persistent inflammatory host response
    Stephania A Cormier
    Division of Hematology and Oncology, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA
    J Leukoc Biol 79:1131-9. 2006
    ....
  21. ncbi request reprint Eosinophils and asthma
    Elizabeth A Jacobsen
    Division of Pulmonary Medicine, SCJMRB RESEARCH, Mayo Clinic Arizona, 13400 E Shea Boulevard, Scottsdale, AZ 85259, USA
    Curr Allergy Asthma Rep 7:18-26. 2007
    ..This review highlights the roles of eosinophils in asthma...
  22. ncbi request reprint In vitro assessment of chemokine receptor-ligand interactions mediating mouse eosinophil migration
    Michael T Borchers
    Mayo Clinic Scottsdale, Scottsdale, Arizona 85259, USA
    J Leukoc Biol 71:1033-41. 2002
    ..Collectively, these observations reveal physiologically relevant distinctions in mechanisms mediating human and mouse eosinophil migration that potentially reflect evolutionary disparities between these species...
  23. ncbi request reprint Pulmonary pathologies in pallid mice result from nonhematopoietic defects
    Michael P McGarry
    Department of Biochemistry and Molecular Biology, S C Johnson Research Building, Scottsdale, Arizona 85259, USA
    Exp Mol Pathol 72:213-20. 2002
    ....
  24. ncbi request reprint Eosinophils: singularly destructive effector cells or purveyors of immunoregulation?
    Elizabeth A Jacobsen
    Division of Pulmonary Medicine, Department of Biocheistry and Molecular Biology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA
    J Allergy Clin Immunol 119:1313-20. 2007
    ....

Research Grants19

  1. Eosinophil Recruitment and Activation in Solid Tumors
    James Lee; Fiscal Year: 2009
    ..e., the release of toxic cationic secondary granule proteins) has direct effects on mammary gland tumors. ..
  2. Eosinophil Activities in Murine Models of Lung Diesease
    JAMES JOSEPH LEE; Fiscal Year: 2010
    ..Indeed, our use of eosinophil-less mice and adoptive cell transfer has led us to suggest that eosinophils are required for the activation/recruitment of allergen-specific T cells that, in turn, promote respiratory inflammation. ..
  3. Mechanisms of Eosinophil Effector Functions in the Lung
    James Lee; Fiscal Year: 2007
    ..abstract_text> ..
  4. Mechanisms of Eosinophil Effector Functions in the Lung
    James Lee; Fiscal Year: 2006
    ..abstract_text> ..
  5. EOSINOPHIL ACTIVITIES IN MURINE MODELS OF LUNG DISEASE
    James Lee; Fiscal Year: 2003
    ..End of Abstract.) ..
  6. Mechanisms of Eosinophil Effector Functions in the Lung
    James Lee; Fiscal Year: 2009
    ..abstract_text> ..
  7. Eosinophil Recruitment and Activation in Solid Tumors
    James Lee; Fiscal Year: 2009
    ..e., the release of toxic cationic secondary granule proteins) has direct effects on mammary gland tumors. ..
  8. EOSINOPHIL ACTIVITIES IN MURINE MODELS OF LUNG DISEASE
    James Lee; Fiscal Year: 2007
    ..abstract_text> ..
  9. Mechanisms of Eosinophil Effector Functions in the Lung
    James Lee; Fiscal Year: 2005
    ....
  10. Eosinophil Activities in Murine Models of Lung Diesease
    James Lee; Fiscal Year: 2009
    ..Indeed, our use of eosinophil-less mice and adoptive cell transfer has led us to suggest that eosinophils are required for the activation/recruitment of allergen-specific T cells that, in turn, promote respiratory inflammation. ..