Nathan K Lebrasseur

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Postnatal PPARdelta activation and myostatin inhibition exert distinct yet complimentary effects on the metabolic profile of obese insulin-resistant mice
    Barbara L Bernardo
    Cardiovascular, Metabolic and Endocrine Diseases, Pfizer Global Research and Development, Groton, Connecticut, United States of America
    PLoS ONE 5:e11307. 2010
  2. pmc Skeletal muscle mass is associated with bone geometry and microstructure and serum insulin-like growth factor binding protein-2 levels in adult women and men
    Nathan K Lebrasseur
    College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Bone Miner Res 27:2159-69. 2012
  3. pmc Metabolic benefits of resistance training and fast glycolytic skeletal muscle
    Nathan K Lebrasseur
    Robert and Arlene Kogod Center on Aging, Department of Physical Medicine and Rehabilitation, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Am J Physiol Endocrinol Metab 300:E3-10. 2011
  4. doi request reprint Building muscle, browning fat and preventing obesity by inhibiting myostatin
    N K Lebrasseur
    Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Diabetologia 55:13-7. 2012
  5. ncbi request reprint Myostatin inhibition enhances the effects of exercise on performance and metabolic outcomes in aged mice
    Nathan K Lebrasseur
    Cardiovascular, Metabolic and Endocrine Diseases, Pfizer Global Research and Development, Eastern Point Road, MS 8220 3001, Groton, CT 06340, USA
    J Gerontol A Biol Sci Med Sci 64:940-8. 2009
  6. pmc Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
    Darren J Baker
    Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Nature 479:232-6. 2011
  7. ncbi request reprint Myostatin and sarcopenia: opportunities and challenges - a mini-review
    Thomas A White
    Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minn, USA
    Gerontology 60:289-93. 2014
  8. pmc Liver-specific GH receptor gene-disrupted (LiGHRKO) mice have decreased endocrine IGF-I, increased local IGF-I, and altered body size, body composition, and adipokine profiles
    Edward O List
    Edison Biotechnology Institute E O L, D E B, K F, A J, B K, E A J, W Z, J J K, Department of Specialty Medicine, Heritage College of Osteopathic Medicine E O L, School of Applied Health Sciences and Wellness D E B, Department of Biomedical Sciences, Heritage College of Osteopathic Medicine D E B, A J, J J K, Ohio University, Athens, Ohio 45701 2942 Department of Internal Medicine F W, A B, Geriatrics Research, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9628 Robert and Arlene Kogod Center on Aging M B S, T A W, N K L, T P, T T, J L K, Mayo Clinic, Rochester, Minnesota 55905 0002 College of Medicine, Burnett School of Biomedical Sciences X Z, M M M, University of Central Florida, Orlando, Division of Respiratory Medicine
    Endocrinology 155:1793-805. 2014
  9. pmc Physiologic and metabolic safety of butyrylcholinesterase gene therapy in mice
    Vishakantha Murthy
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN 55905, USA Electronic address
    Vaccine 32:4155-62. 2014

Collaborators

Detail Information

Publications9

  1. pmc Postnatal PPARdelta activation and myostatin inhibition exert distinct yet complimentary effects on the metabolic profile of obese insulin-resistant mice
    Barbara L Bernardo
    Cardiovascular, Metabolic and Endocrine Diseases, Pfizer Global Research and Development, Groton, Connecticut, United States of America
    PLoS ONE 5:e11307. 2010
    ....
  2. pmc Skeletal muscle mass is associated with bone geometry and microstructure and serum insulin-like growth factor binding protein-2 levels in adult women and men
    Nathan K Lebrasseur
    College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Bone Miner Res 27:2159-69. 2012
    ..Collectively, these data add to the growing body of evidence supporting the highly-integrated nature of skeletal muscle and bone, and provide new insights into potential biomarkers that reflect the health of the musculoskeletal system...
  3. pmc Metabolic benefits of resistance training and fast glycolytic skeletal muscle
    Nathan K Lebrasseur
    Robert and Arlene Kogod Center on Aging, Department of Physical Medicine and Rehabilitation, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Am J Physiol Endocrinol Metab 300:E3-10. 2011
    ....
  4. doi request reprint Building muscle, browning fat and preventing obesity by inhibiting myostatin
    N K Lebrasseur
    Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Diabetologia 55:13-7. 2012
    ..Herein, these data, areas in need of further investigation and the evidence that implicates myostatin as a target for obesity and type 2 diabetes mellitus are discussed...
  5. ncbi request reprint Myostatin inhibition enhances the effects of exercise on performance and metabolic outcomes in aged mice
    Nathan K Lebrasseur
    Cardiovascular, Metabolic and Endocrine Diseases, Pfizer Global Research and Development, Eastern Point Road, MS 8220 3001, Groton, CT 06340, USA
    J Gerontol A Biol Sci Med Sci 64:940-8. 2009
    ..The data suggest that the combination of exercise training and myostatin blockade may significantly improve physical function and whole-body metabolism in older individuals...
  6. pmc Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
    Darren J Baker
    Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Nature 479:232-6. 2011
    ..These data indicate that cellular senescence is causally implicated in generating age-related phenotypes and that removal of senescent cells can prevent or delay tissue dysfunction and extend healthspan...
  7. ncbi request reprint Myostatin and sarcopenia: opportunities and challenges - a mini-review
    Thomas A White
    Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minn, USA
    Gerontology 60:289-93. 2014
    ..The complex biology of myostatin, the promise of myostatin inhibition as an effective means to counter sarcopenia, and the challenges facing its clinical translation are reviewed herein. © 2014 S. Karger AG, Basel. ..
  8. pmc Liver-specific GH receptor gene-disrupted (LiGHRKO) mice have decreased endocrine IGF-I, increased local IGF-I, and altered body size, body composition, and adipokine profiles
    Edward O List
    Edison Biotechnology Institute E O L, D E B, K F, A J, B K, E A J, W Z, J J K, Department of Specialty Medicine, Heritage College of Osteopathic Medicine E O L, School of Applied Health Sciences and Wellness D E B, Department of Biomedical Sciences, Heritage College of Osteopathic Medicine D E B, A J, J J K, Ohio University, Athens, Ohio 45701 2942 Department of Internal Medicine F W, A B, Geriatrics Research, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9628 Robert and Arlene Kogod Center on Aging M B S, T A W, N K L, T P, T T, J L K, Mayo Clinic, Rochester, Minnesota 55905 0002 College of Medicine, Burnett School of Biomedical Sciences X Z, M M M, University of Central Florida, Orlando, Division of Respiratory Medicine
    Endocrinology 155:1793-805. 2014
    ..Furthermore, our data suggest that novel GH-dependent cross talk between liver and adipose is important for regulation of adipokines in vivo. ..
  9. pmc Physiologic and metabolic safety of butyrylcholinesterase gene therapy in mice
    Vishakantha Murthy
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN 55905, USA Electronic address
    Vaccine 32:4155-62. 2014
    ..Hence, viral gene transfer of BChE appears benign and worth exploring as a therapy for cocaine abuse and possibly other disorders as well. ..