Iftikhar Kullo

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Gene expression profiling of peripheral blood mononuclear cells in the setting of peripheral arterial disease
    Rizwan Masud
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester MN 55905, USA
    J Clin Bioinforma 2:6. 2012
  2. pmc Complexity in the genetic architecture of leukoaraiosis in hypertensive sibships from the GENOA Study
    Jennifer A Smith
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA
    BMC Med Genomics 2:16. 2009
  3. pmc Geographic differences in allele frequencies of susceptibility SNPs for cardiovascular disease
    Keyue Ding
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    BMC Med Genet 12:55. 2011
  4. pmc Complement receptor 1 gene variants are associated with erythrocyte sedimentation rate
    Iftikhar J Kullo
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Am J Hum Genet 89:131-8. 2011
  5. ncbi request reprint Markers of inflammation are inversely associated with VO2 max in asymptomatic men
    Iftikhar J Kullo
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo College of Medicine, Rochester, Minnesota, USA
    J Appl Physiol 102:1374-9. 2007
  6. ncbi request reprint Brachial artery diameter and vasodilator response to nitroglycerine, but not flow-mediated dilatation, are associated with the presence and quantity of coronary artery calcium in asymptomatic adults
    Iftikhar J Kullo
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Clin Sci (Lond) 112:175-82. 2007
  7. ncbi request reprint Novel genomic loci influencing plasma homocysteine levels
    Iftikhar J Kullo
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minn 55905, USA
    Stroke 37:1703-9. 2006
  8. ncbi request reprint Quantitative trait loci influencing low density lipoprotein particle size in African Americans
    Iftikhar J Kullo
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    J Lipid Res 47:1457-62. 2006
  9. ncbi request reprint Association of plasma homocysteine with coronary artery calcification in different categories of coronary heart disease risk
    Ifirkhar J Kullo
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Mayo Clin Proc 81:177-82. 2006
  10. pmc Association of polymorphisms in NOS3 with the ankle-brachial index in hypertensive adults
    Iftikhar J Kullo
    Divisions of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Atherosclerosis 196:905-12. 2008

Research Grants

  1. Functional Arterial Changes in Atherogenesis
    Iftikhar Kullo; Fiscal Year: 2003
  2. Determinants of arterial function in hypertension
    Iftikhar J Kullo; Fiscal Year: 2010
  3. Determinants of arterial function in hypertension
    Iftikhar Kullo; Fiscal Year: 2009
  4. Biomarkers of Peripheral Arterial Disease
    Iftikhar Kullo; Fiscal Year: 2007
  5. Proteomic Markers of Arteriosclerosis
    Iftikhar Kullo; Fiscal Year: 2007
  6. Functional Arterial Changes in Atherogenesis
    Iftikhar Kullo; Fiscal Year: 2007
  7. Functional Arterial Changes in Atherogenesis
    Iftikhar Kullo; Fiscal Year: 2006

Collaborators

Detail Information

Publications71

  1. pmc Gene expression profiling of peripheral blood mononuclear cells in the setting of peripheral arterial disease
    Rizwan Masud
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester MN 55905, USA
    J Clin Bioinforma 2:6. 2012
    ..abstract:..
  2. pmc Complexity in the genetic architecture of leukoaraiosis in hypertensive sibships from the GENOA Study
    Jennifer A Smith
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA
    BMC Med Genomics 2:16. 2009
    ....
  3. pmc Geographic differences in allele frequencies of susceptibility SNPs for cardiovascular disease
    Keyue Ding
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    BMC Med Genet 12:55. 2011
    ....
  4. pmc Complement receptor 1 gene variants are associated with erythrocyte sedimentation rate
    Iftikhar J Kullo
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Am J Hum Genet 89:131-8. 2011
    ....
  5. ncbi request reprint Markers of inflammation are inversely associated with VO2 max in asymptomatic men
    Iftikhar J Kullo
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo College of Medicine, Rochester, Minnesota, USA
    J Appl Physiol 102:1374-9. 2007
    ..52 +/- 0.30 (SE), P = 0.088] were each inversely associated with Vo(2 max). In conclusion, higher circulating levels of IL-6, CRP, and fibrinogen are independently associated with lower Vo(2 max) in asymptomatic men...
  6. ncbi request reprint Brachial artery diameter and vasodilator response to nitroglycerine, but not flow-mediated dilatation, are associated with the presence and quantity of coronary artery calcium in asymptomatic adults
    Iftikhar J Kullo
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Clin Sci (Lond) 112:175-82. 2007
    ..We conclude that greater diameter of the brachial artery and lower vasodilator response to nitroglycerine, but not FMD, are associated with subclinical coronary atherosclerosis...
  7. ncbi request reprint Novel genomic loci influencing plasma homocysteine levels
    Iftikhar J Kullo
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minn 55905, USA
    Stroke 37:1703-9. 2006
    ..We performed linkage analyses to identify genomic regions that influence homocysteine levels in blacks and non-Hispanic whites...
  8. ncbi request reprint Quantitative trait loci influencing low density lipoprotein particle size in African Americans
    Iftikhar J Kullo
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    J Lipid Res 47:1457-62. 2006
    ..9 cM, LOD = 2.06, P = 0.0069). These genomic regions may contain genes that influence interindividual variation in LDL particle size and potentially coronary heart disease susceptibility in African Americans...
  9. ncbi request reprint Association of plasma homocysteine with coronary artery calcification in different categories of coronary heart disease risk
    Ifirkhar J Kullo
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Mayo Clin Proc 81:177-82. 2006
    ..To Investigate the association of plasma homocystelne with coronary artery calcification (CAC) in strata based on 10-year risk of coronary heart disease (CHD) in a cohort enriched in persons with hypertension...
  10. pmc Association of polymorphisms in NOS3 with the ankle-brachial index in hypertensive adults
    Iftikhar J Kullo
    Divisions of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Atherosclerosis 196:905-12. 2008
    ..These findings motivate further investigation of the role of NOS3 variants in determining susceptibility to peripheral arterial disease...
  11. ncbi request reprint Arterial ultrasonography and tonometry as adjuncts to cardiovascular risk stratification
    Iftikhar J Kullo
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 49:1413-26. 2007
    ....
  12. pmc Early identification of cardiovascular risk using genomics and proteomics
    Iftikhar J Kullo
    Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Nat Rev Cardiol 7:309-17. 2010
    ..In this article, we use the specific example of atherosclerosis to discuss the role of genomics and proteomics in cardiovascular risk assessment...
  13. ncbi request reprint Association of cardiovascular risk factors with microvascular and conduit artery function in hypertensive subjects
    Iftikhar J Kullo
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Am J Hypertens 20:735-42. 2007
    ..We investigated the association of cardiovascular (CV) risk factors with microvascular and conduit artery function in hypertensive subjects...
  14. pmc Patterns of population differentiation of candidate genes for cardiovascular disease
    Iftikhar J Kullo
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA
    BMC Genet 8:48. 2007
    ..Genotype data were obtained from the HapMap database...
  15. ncbi request reprint Mechanisms of disease: The genetic basis of coronary heart disease
    Iftikhar J Kullo
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Nat Clin Pract Cardiovasc Med 4:558-69. 2007
    ..Such knowledge could refine cardiovascular risk stratification and facilitate the development of new therapies...
  16. pmc Leveraging informatics for genetic studies: use of the electronic medical record to enable a genome-wide association study of peripheral arterial disease
    Iftikhar J Kullo
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA
    J Am Med Inform Assoc 17:568-74. 2010
    ..There is significant interest in leveraging the electronic medical record (EMR) to conduct genome-wide association studies (GWAS)...
  17. ncbi request reprint Aortic pulse wave velocity is associated with the presence and quantity of coronary artery calcium: a community-based study
    Iftikhar J Kullo
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Hypertension 47:174-9. 2006
    ..We conclude that aPWV is related to subclinical coronary atherosclerosis independent of conventional risk factors (including indices of blood pressure) and may be a biomarker of cardiovascular risk in asymptomatic individuals...
  18. ncbi request reprint A genome-wide linkage scan for ankle-brachial index in African American and non-Hispanic white subjects participating in the GENOA study
    Iftikhar J Kullo
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, 200 First Street Southwest, Rochester, MN 55905, USA
    Atherosclerosis 187:433-8. 2006
    ..In conclusion, ABI is a modestly heritable trait in AA and NHW hypertensive sibships. Quantitative trait linkage analyses identified several chromosomal regions that may harbor genes influencing ABI...
  19. ncbi request reprint C-reactive protein is related to arterial wave reflection and stiffness in asymptomatic subjects from the community
    Iftikhar J Kullo
    Divisions of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Am J Hypertens 18:1123-9. 2005
    ....
  20. ncbi request reprint Low-density lipoprotein particle size and coronary atherosclerosis in subjects belonging to hypertensive sibships
    Iftikhar J Kullo
    Divisions of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Am J Hypertens 17:845-51. 2004
    ..Whether LDL particle size is associated with the extent of coronary atherosclerosis in hypertensive sibships is unknown...
  21. ncbi request reprint Ethnic differences in peripheral arterial disease in the NHLBI Genetic Epidemiology Network of Arteriopathy (GENOA) study
    Iftikhar J Kullo
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, 200 First Street Southwest, Rochester, MN 55905, USA
    Vasc Med 8:237-42. 2003
    ..Identifying additional 'novel' risk factors that account for the ethnic differences in PAD is an important next step towards understanding why such differences exist and developing more effective strategies to reduce the burden of PAD...
  22. ncbi request reprint Relation of C-reactive protein and fibrinogen to coronary artery calcium in subjects with systemic hypertension
    Iftikhar J Kullo
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Am J Cardiol 92:56-8. 2003
  23. ncbi request reprint Relation of low cardiorespiratory fitness to the metabolic syndrome in middle-aged men
    Iftikhar J Kullo
    Division of Cardiovascular Disease, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Am J Cardiol 90:795-7. 2002
  24. ncbi request reprint Pleiotropic genetic effects contribute to the correlation between HDL cholesterol, triglycerides, and LDL particle size in hypertensive sibships
    Iftikhar J Kullo
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, Minnesota, USA
    Am J Hypertens 18:99-103. 2005
    ..We investigated heritability of these three lipid traits and the extent to which shared effects of genes (pleiotropy) contribute to the additive genetic variation in each trait in hypertensive sibships...
  25. ncbi request reprint Conditional risk factors for atherosclerosis
    Iftikhar J Kullo
    Department of Internal Medicine and Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Mayo Clin Proc 80:219-30. 2005
    ..The putative mechanisms of risk, available assays, evidence for association with CHD, and the clinical implications thereof are discussed for each of the risk factors...
  26. ncbi request reprint Comparison of numbers of circulating blood monocytes in men grouped by body mass index (<25, 25 to <30, > or =30)
    Iftikhar J Kullo
    Division of Cardiovascular Disease, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Am J Cardiol 89:1441-3. 2002
  27. ncbi request reprint A novel quantitative trait locus on chromosome 1 with pleiotropic effects on HDL-cholesterol and LDL particle size in hypertensive sibships
    Iftikhar J Kullo
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Am J Hypertens 18:1084-90. 2005
    ..We performed univariate and bivariate linkage analyses to identify genomic regions that influence levels of these traits and exert pleiotropic effects on the traits in hypertensive sibships...
  28. ncbi request reprint Lack of association between lipoprotein(a) and coronary artery calcification in the Genetic Epidemiology Network of Arteriopathy (GENOA) study
    Iftikhar J Kullo
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Mayo Clin Proc 79:1258-63. 2004
    ..To investigate the relationship between lipoprotein(a) [Lp(a)] levels and the extent of coronary atherosclerosis in a cohort that consisted predominantly of hypertensive patients...
  29. pmc Genotype-informed estimation of risk of coronary heart disease based on genome-wide association data linked to the electronic medical record
    Keyue Ding
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    BMC Cardiovasc Disord 11:66. 2011
    ..We investigated whether measured and imputed genotypes from a GWAS dataset linked to the electronic medical record alter estimates of coronary heart disease (CHD) risk...
  30. pmc Forearm vascular reactivity and arterial stiffness in asymptomatic adults from the community
    A Rauoof Malik
    Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
    Hypertension 51:1512-8. 2008
    ....
  31. pmc Association of serum myeloperoxidase with the ankle-brachial index and peripheral arterial disease
    Zeenat Ali
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Vasc Med 14:215-20. 2009
    ..001 and p = 0.018, respectively). We conclude that higher MPO levels are associated with lower ABI and the presence of PAD in African-Americans and non-Hispanic white individuals...
  32. pmc Relation of plasma midregional proatrial natriuretic peptide to target organ damage in adults with systemic hypertension
    Mahyar Khaleghi
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA
    Am J Cardiol 103:1255-60. 2009
    ..002) and greater UACR (p = 0.001), but not after adjustment for the covariates listed earlier. In conclusion, plasma MR-proANP may be a marker of target organ damage in the setting of hypertension, especially in African-Americans...
  33. ncbi request reprint Relation of markers of inflammation (C-reactive protein, white blood cell count, and lipoprotein-associated phospholipase A2) to the ankle-brachial index
    Simone Santos
    Divisions of Cardiovascular Disease, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Vasc Med 9:171-6. 2004
    ..The association of Lp-PLA2 with ABI merits further study...
  34. ncbi request reprint Association of novel risk factors with the ankle brachial index in African American and non-Hispanic white populations
    Farhan J Khawaja
    Department of Internal Medicine, College of Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Mayo Clin Proc 82:709-16. 2007
    ....
  35. ncbi request reprint Association of plasma resistin with glomerular filtration rate and albuminuria in hypertensive adults
    Allison A Ellington
    Division of Cardiovascular Diseases, Mayo Clinic, 200 First St Southwest, Rochester, MN 55905, USA
    Hypertension 50:708-14. 2007
    ..This association was independent of coronary heart disease risk factors and markers of insulin resistance and inflammation...
  36. ncbi request reprint Associations of serum uric acid with markers of inflammation, metabolic syndrome, and subclinical coronary atherosclerosis
    Thais de A Coutinho
    Department of Internal Medicine, Mayo College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Am J Hypertens 20:83-9. 2007
    ....
  37. pmc Aortic augmentation index is associated with the ankle-brachial index: a community-based study
    Mahyar Khaleghi
    Division of Cardiovascular Diseases, Gonda Vascular Center, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
    Atherosclerosis 195:248-53. 2007
    ..We investigated whether aortic augmentation index (AIx), a measure of arterial stiffness and wave reflection, was associated with the ankle-brachial index (ABI), a measure of peripheral arterial disease (PAD)...
  38. pmc Sex and ethnic differences in 47 candidate proteomic markers of cardiovascular disease: the Mayo Clinic proteomic markers of arteriosclerosis study
    Charles X Kim
    Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 5:e9065. 2010
    ..We examined differences in circulating levels of 47 novel protein markers of CVD in 2561 men and women of African-American (AA) and non-Hispanic White (NHW) ethnicity, enrolled at geographically distinct sites...
  39. ncbi request reprint Aortic augmentation index is inversely associated with cardiorespiratory fitness in men without known coronary heart disease
    Josepha Binder
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Am J Hypertens 19:1019-24. 2006
    ..We investigated whether the aortic augmentation index (AIx), a measure of arterial wave reflection and stiffness, is associated with cardiorespiratory fitness in men without known coronary heart disease (CHD)...
  40. pmc Serum osteocalcin is associated with measures of insulin resistance, adipokine levels, and the presence of metabolic syndrome
    Umer Saleem
    Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Arterioscler Thromb Vasc Biol 30:1474-8. 2010
    ..We investigated whether serum osteocalcin was associated with measures of insulin resistance, circulating adipokine levels, and the presence of metabolic syndrome (MetSyn)...
  41. pmc Association of serum osteoprotegerin with ankle-brachial index and urine albumin: creatinine ratio in African-Americans and non-Hispanic whites
    Zeenat Ali
    Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, United States
    Atherosclerosis 206:575-80. 2009
    ..106). We conclude that higher OPG levels are associated with lower ABI and higher UACR, independent of conventional risk factors and plasma CRP...
  42. pmc Association of soluble cell adhesion molecules with ankle-brachial index in a biethnic cohort of predominantly hypertensive individuals
    Mahyar Khaleghi
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Clin Chem 54:1788-95. 2008
    ....
  43. ncbi request reprint Genetic markers of vascular aging
    Mahyar Khaleghi
    Mayo Clinic, Division of Cardiovascular Diseases, 200 First Street Southwest, Rochester, MN 55905, USA
    Biomark Med 1:453-65. 2007
    ..Such findings will facilitate the development of novel therapies to retard vascular aging...
  44. pmc Plasma carboxy-terminal provasopressin (copeptin): a novel marker of insulin resistance and metabolic syndrome
    Umer Saleem
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 94:2558-64. 2009
    ..Stress-mediated hypothalamic-pituitary-adrenal axis activation, regulated by arginine vasopressin (AVP), may have a role in the pathophysiology of metabolic syndrome (MetSyn)...
  45. ncbi request reprint Methods for the selection of tagging SNPs: a comparison of tagging efficiency and performance
    Keyue Ding
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Eur J Hum Genet 15:228-36. 2007
    ..Tagging consistency between different methods of tSNPs selection was poor. This work demonstrates that when tSNPs-based association studies are undertaken, the choice of method for selecting tSNPs requires careful consideration...
  46. pmc White blood cell count predicts all-cause mortality in patients with suspected peripheral arterial disease
    Faisal A Arain
    The Gonda Vascular Center and Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minn 55905, USA
    Am J Med 122:874.e1-7. 2009
    ....
  47. pmc Plasma midregional pro-atrial natriuretic peptide is associated with blood pressure indices and hypertension severity in adults with hypertension
    Mahyar Khaleghi
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA
    Am J Hypertens 22:425-31. 2009
    ..We tested the hypothesis that in adults with essential hypertension, plasma levels of MR-proANP would be associated with systolic blood pressure (SBP), pulse pressure, and hypertension severity...
  48. pmc Molecular population genetics of PCSK9: a signature of recent positive selection
    Keyue Ding
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Pharmacogenet Genomics 18:169-79. 2008
    ..Both rare mutations and common variants in the coding regions of PCSK9 affect LDL cholesterol levels and coronary heart disease risk, as well as response to lipid-lowering therapy...
  49. pmc Association of C-reactive protein with mild cognitive impairment
    Rosebud O Roberts
    Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, MN, USA
    Alzheimers Dement 5:398-405. 2009
    ..This study examined the association of inflammatory markers in serum or plasma with prevalent MCI and MCI subtypes in a population-based sample...
  50. ncbi request reprint Molecular evolution of 5' flanking regions of 87 candidate genes for atherosclerotic cardiovascular disease
    Keyue Ding
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Genet Epidemiol 30:557-69. 2006
    ....
  51. pmc Novel markers of peripheral arterial disease
    Farhan J Khawaja
    Department of Medicine, Division of Cardiovascular Diseases and the Gonda Vascular Center, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Vasc Med 14:381-92. 2009
    ..In this review, we discuss available evidence for associations between novel circulating markers and several aspects of PAD including disease susceptibility, progression, functional limitation, and adverse outcomes...
  52. ncbi request reprint Association between metabolic syndrome and subclinical coronary atherosclerosis in asymptomatic adults
    Iftikhar J Kullo
    Division of Cardiovascular Disease, Mayo Clinic and Foundation, Rochester, Minnesota, USA
    Am J Cardiol 94:1554-8. 2004
    ..The association was independent of 10-year risk of coronary heart disease based on the Framingham risk score...
  53. ncbi request reprint Association between lipoprotein-associated phospholipase A2 and cardiovascular disease: a systematic review
    Carolina A Garza
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Mayo Clin Proc 82:159-65. 2007
    ..To estimate the association between plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) levels and cardiovascular disease (CVD)...
  54. ncbi request reprint Early-onset peripheral arterial occlusive disease: clinical features and determinants of disease severity and location
    Simone Barretto
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Vasc Med 8:95-100. 2003
    ..Low HDL-cholesterol and female sex were associated with disease severity. An aggressive approach to diagnosis and treatment may be warranted as atherosclerosis in other arterial beds was prevalent in half of the patients...
  55. pmc Mid-regional pro-adrenomedullin is associated with pulse pressure, left ventricular mass, and albuminuria in African Americans with hypertension
    Malik A Al-Omari
    Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Am J Hypertens 22:860-6. 2009
    ..Adrenomedullin (ADM) is a circulating vasoactive peptide with vasodilatory and antiproliferative effects that has been reported to be elevated in adults with hypertension...
  56. pmc Association of serum osteoprotegerin with left ventricular mass in African American adults with hypertension
    Amit Noheria
    Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Am J Hypertens 23:767-74. 2010
    ..Serum osteoprotegerin level has been reported to be associated with LVH. We investigated the association of osteoprotegerin with LV mass (LVM) in 898 African-Americans with hypertension (mean age 65 years, 71% women)...
  57. ncbi request reprint Atherogenic lipoprotein subprofiling
    Allison A Ellington
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Adv Clin Chem 46:295-317. 2008
    ..This chapter includes a brief review of lipoprotein biology and presents an overview of the association between novel lipoprotein markers and CHD risk. We also discuss methodologies currently available for atherogenic lipid subprofiling...
  58. pmc Biomarkers of left ventricular hypertrophy and remodeling in blacks
    Thais Coutinho
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Hypertension 58:920-5. 2011
    ..Higher circulating levels of natriuretic peptides, adrenomedullin, endothelin, and osteoprotegerin were associated with increased LV mass index, providing insights into the pathophysiology of LV hypertrophy in blacks...
  59. pmc Increased serum N-terminal pro-B-type natriuretic peptide levels in patients with medial arterial calcification and poorly compressible leg arteries
    Hayan Jouni
    Mayo Clinic, Rochester, MN 55905, USA
    Arterioscler Thromb Vasc Biol 31:197-202. 2011
    ....
  60. pmc Measurement and quality control issues in multiplex protein assays: a case study
    Allison A Ellington
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA
    Clin Chem 55:1092-9. 2009
    ..Here, we use measurements of 15 protein biomarkers from a large study to illustrate processing, analytic, and quality control issues with multiplexed immunoassays...
  61. ncbi request reprint Multiple cardiovascular complications in a patient with relapsing polychondritis
    Simone N Barretto
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minn 55905, USA
    Mayo Clin Proc 77:971-4. 2002
    ..This case illustrates the multiple, varied, and potentially fatal cardiovascular complications that can occur with this disorder. Patients with relapsing polychondritis should be monitored closely for development of such complications...
  62. pmc Antibody-based protein multiplex platforms: technical and operational challenges
    Allison A Ellington
    Division of Cardiovascular Diseases, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Clin Chem 56:186-93. 2010
    ..This concept has stimulated development of multiplexed immunoassay platforms that provide multiple, parallel protein measurements on the same specimen...
  63. pmc Evidence for positive selection in the C-terminal domain of the cholesterol metabolism gene PCSK9 based on phylogenetic analysis in 14 primate species
    Keyue Ding
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, Minnesota, United States of America
    PLoS ONE 2:e1098. 2007
    ..Whether PCSK9 experienced significant selective pressure to maintain a functional relationship with its target protein, LDL-R, is unknown...
  64. pmc Impact of ezetimibe on atherosclerosis: is the jury still out?
    Firas J Al Badarin
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 84:353-61. 2009
    ..Use of ezetimibe as a second- or third-line agent to achieve low-density lipoprotein cholesterol treatment goals seems appropriate on the basis of the available evidence...
  65. ncbi request reprint Sex-specific associations of lipoprotein(a) with presence and quantity of coronary artery calcification in an asymptomatic population
    Andrea E Cassidy
    Department of Epidemiology, University of Michigan, Ann Arbor, Michigan 47104 3028, USA
    Med Sci Monit 10:CR493-503. 2004
    ..The relationship between serum Lp(a) and coronary artery calcification (CAC), a measure of subclinical coronary artery atherosclerosis, has not been extensively explored...
  66. ncbi request reprint Coronary artery calcification progression is heritable
    Andrea E Cassidy-Bushrow
    Department of Epidemiology, University of Michigan, 611 Church St, Ann Arbor, MI 48104 3028, USA
    Circulation 116:25-31. 2007
    ..Serial measures of CAC quantify progression of calcified coronary artery plaque. Little is known about the role of genetic factors in progression of CAC quantity...
  67. ncbi request reprint Measures of arterial stiffness and wave reflection are associated with walking distance in patients with peripheral arterial disease
    LaPrincess C Brewer
    George Washington University School of Medicine, Washington, DC, USA
    Atherosclerosis 191:384-90. 2007
    ..9 at rest or post-exercise, n=82). In conclusion, measures of arterial stiffness and wave reflection are associated with walking distance in patients with PAD and may be a target of therapy in such patients...
  68. ncbi request reprint Markers of inflammation and thrombosis: clues to plaque instability?
    Iftikhar J Kullo
    Am Heart J 145:941-2. 2003
  69. ncbi request reprint Progression of subclinical coronary atherosclerosis: does obesity make a difference?
    Andrea E Cassidy
    Department of Epidemiology, University of Michigan, 611 Church St, Ann Arbor, MI 48104 3028, USA
    Circulation 111:1877-82. 2005
    ..The present study examined associations between obesity measures and progression of CAC in those at higher (> or =10%) and lower (<10%) 10-year coronary heart disease risk according to the Framingham risk equation...
  70. ncbi request reprint Genetic determinants of HDL: monogenic disorders and contributions to variation
    Kathy L E Klos
    aHuman Genetics Center, University of Texas Health Science Center, Houston, Texas 77225, USA
    Curr Opin Cardiol 22:344-51. 2007
    ..This review focuses on recent progress towards the characterization of genetic variations that contribute to interindividual variation in plasma high-density lipoprotein cholesterol levels in the general population...
  71. ncbi request reprint Comparative and evolutionary pharmacogenetics of ABCB1: complex signatures of positive selection on coding and regulatory regions
    Haijian Wang
    MOE Key Laboratory of Contemporary Anthropology, Center for Evolutionary Biology, State Key Laboratory of Genetic Engineering, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, PR China
    Pharmacogenet Genomics 17:667-78. 2007
    ..Fully profiling the alletic architecture and explicitly interrogating the natural selection at ABCBI are needed to understand its evolutionary population genetics...

Research Grants14

  1. Functional Arterial Changes in Atherogenesis
    Iftikhar Kullo; Fiscal Year: 2003
    ....
  2. Determinants of arterial function in hypertension
    Iftikhar J Kullo; Fiscal Year: 2010
    ..The aim of our investigation is to identify novel proteins and genes that influence arterial function. Such work will help in identifying those at risk of developing arterial disease and facilitate development of new therapies. ..
  3. Determinants of arterial function in hypertension
    Iftikhar Kullo; Fiscal Year: 2009
    ..The aim of our investigation is to identify novel proteins and genes that influence arterial function. Such work will help in identifying those at risk of developing arterial disease and facilitate development of new therapies. ..
  4. Biomarkers of Peripheral Arterial Disease
    Iftikhar Kullo; Fiscal Year: 2007
    ..abstract_text> ..
  5. Proteomic Markers of Arteriosclerosis
    Iftikhar Kullo; Fiscal Year: 2007
    ....
  6. Functional Arterial Changes in Atherogenesis
    Iftikhar Kullo; Fiscal Year: 2007
    ..abstract_text> ..
  7. Functional Arterial Changes in Atherogenesis
    Iftikhar Kullo; Fiscal Year: 2006
    ..abstract_text> ..