Thomas L Kukar

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice
    Thomas Kukar
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    BMC Neurosci 8:54. 2007
  2. pmc Possible mechanisms of action of NSAIDs and related compounds that modulate gamma-secretase cleavage
    Thomas Kukar
    Department of Neuroscience, Mayo Clinic, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, Florida 32224, USA
    Curr Top Med Chem 8:47-53. 2008
  3. pmc Substrate-targeting gamma-secretase modulators
    Thomas L Kukar
    Department of Neuroscience, Mayo Clinic, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, Florida 32224, USA
    Nature 453:925-9. 2008
  4. ncbi request reprint Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production
    Thomas Kukar
    Department of Neuroscience, Mayo Clinic, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, Florida 32224, USA
    Nat Med 11:545-50. 2005
  5. ncbi request reprint Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase
    Andrew C Nyborg
    Department of Neuroscience, Mayo Clinic Jacksonville, Mayo Clinic College of Medicine, 4500 San Pablo Rd, Jacksonville, Florida 32224, USA
    FASEB J 20:1671-9. 2006

Detail Information

Publications5

  1. pmc Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice
    Thomas Kukar
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    BMC Neurosci 8:54. 2007
    ..In this study we report the effect of chronic R-flurbiprofen treatment on cognition and Abeta loads in Tg2576 APP mice...
  2. pmc Possible mechanisms of action of NSAIDs and related compounds that modulate gamma-secretase cleavage
    Thomas Kukar
    Department of Neuroscience, Mayo Clinic, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, Florida 32224, USA
    Curr Top Med Chem 8:47-53. 2008
    ..The evidence indicating that these chemicals modulate the production of Abeta peptides by directly interacting with the gamma-secretase complex is summarized...
  3. pmc Substrate-targeting gamma-secretase modulators
    Thomas L Kukar
    Department of Neuroscience, Mayo Clinic, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, Florida 32224, USA
    Nature 453:925-9. 2008
    ..These data also demonstrate the existence and feasibility of 'substrate targeting' by small-molecule effectors of proteolytic enzymes, which if generally applicable may significantly broaden the current notion of 'druggable' targets...
  4. ncbi request reprint Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production
    Thomas Kukar
    Department of Neuroscience, Mayo Clinic, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, Florida 32224, USA
    Nat Med 11:545-50. 2005
    ....
  5. ncbi request reprint Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase
    Andrew C Nyborg
    Department of Neuroscience, Mayo Clinic Jacksonville, Mayo Clinic College of Medicine, 4500 San Pablo Rd, Jacksonville, Florida 32224, USA
    FASEB J 20:1671-9. 2006
    ..Based on these data, we hypothesize that mSPP is a potential a novel therapeutic target for malaria...