Keith Knutson

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Functional folate receptor alpha is elevated in the blood of ovarian cancer patients
    Eati Basal
    Department of Immunology, Mayo Clinic, Rochester, MN, USA
    PLoS ONE 4:e6292. 2009
  2. pmc Optimizing patient derived mesenchymal stem cells as virus carriers for a phase I clinical trial in ovarian cancer
    Emily K Mader
    Department of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Transl Med 11:20. 2013
  3. pmc A profile of immune response to herpesvirus is associated with radiographic joint damage in rheumatoid arthritis
    John M Davis
    Division of Rheumatology, Department of Medicine, College of Medicine, Mayo Clinic 200 First Street SW, Rochester, MN 55905, USA
    Arthritis Res Ther 14:R24. 2012
  4. pmc Vaccination with a plasmid DNA encoding HER-2/neu together with low doses of GM-CSF and IL-2 in patients with metastatic breast carcinoma: a pilot clinical trial
    Håkan Norell
    Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institutet, Stockholm, Sweden
    J Transl Med 8:53. 2010
  5. pmc Polymorphisms in NF-kappaB inhibitors and risk of epithelial ovarian cancer
    Kristin L White
    Mayo Clinic College of Medicine, Rochester, MN, USA
    BMC Cancer 9:170. 2009
  6. ncbi request reprint Tumor antigen-specific T helper cells in cancer immunity and immunotherapy
    K L Knutson
    Department of Immunology, Mayo Clinic College of Medicine, 342C Guggenheim Bldg, 200 First St SW, Rochester, MN 55906, USA
    Cancer Immunol Immunother 54:721-8. 2005
  7. ncbi request reprint IL-2 immunotoxin therapy modulates tumor-associated regulatory T cells and leads to lasting immune-mediated rejection of breast cancers in neu-transgenic mice
    Keith L Knutson
    Department of Immunology, Mayo Clinic College of Medicine, 342C Guggenheim, 200 First Street SW, Rochester, MN 55905, USA
    J Immunol 177:84-91. 2006
  8. ncbi request reprint Strong-arming immune regulation: suppressing regulatory T-cell function to treat cancers
    Keith L Knutson
    Department of Immunology, Mayo Clinic College of Medicine, 342C Guggenheim, 200 First St SW, Mayo Clinic, Rochester, MN 55905, USA
    Future Oncol 2:379-89. 2006
  9. ncbi request reprint Immunoediting of cancers may lead to epithelial to mesenchymal transition
    Keith L Knutson
    Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 177:1526-33. 2006
  10. ncbi request reprint Augmenting T helper cell immunity in cancer
    K L Knutson
    Department of Immunology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55906, USA
    Curr Drug Targets Immune Endocr Metabol Disord 5:365-71. 2005

Detail Information

Publications57

  1. pmc Functional folate receptor alpha is elevated in the blood of ovarian cancer patients
    Eati Basal
    Department of Immunology, Mayo Clinic, Rochester, MN, USA
    PLoS ONE 4:e6292. 2009
    ..In the current study, the goal was to determine whether ovarian cancer patients (n = 30) had elevated serum levels of a fully functional intact FRalpha compared to matched healthy controls (n = 30)...
  2. pmc Optimizing patient derived mesenchymal stem cells as virus carriers for a phase I clinical trial in ovarian cancer
    Emily K Mader
    Department of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Transl Med 11:20. 2013
    ..In preparation for a clinical trial to use MSC as MV carriers, we obtained cells from ovarian cancer patients and evaluated feasibility and safety of this approach...
  3. pmc A profile of immune response to herpesvirus is associated with radiographic joint damage in rheumatoid arthritis
    John M Davis
    Division of Rheumatology, Department of Medicine, College of Medicine, Mayo Clinic 200 First Street SW, Rochester, MN 55905, USA
    Arthritis Res Ther 14:R24. 2012
    ..This study was undertaken to identify profiles of immune response that correlate with radiographic joint damage as a first step toward the discovery of new pathogenic mechanisms of joint destruction in RA...
  4. pmc Vaccination with a plasmid DNA encoding HER-2/neu together with low doses of GM-CSF and IL-2 in patients with metastatic breast carcinoma: a pilot clinical trial
    Håkan Norell
    Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institutet, Stockholm, Sweden
    J Transl Med 8:53. 2010
    ..Here we report the first administration of a Her2-plasmid DNA (pDNA) vaccine in humans...
  5. pmc Polymorphisms in NF-kappaB inhibitors and risk of epithelial ovarian cancer
    Kristin L White
    Mayo Clinic College of Medicine, Rochester, MN, USA
    BMC Cancer 9:170. 2009
    ..Inhibitors of kappaB (IkappaB) prevent NF-kappaB activation by sequestering NF-kappaB proteins in the cytoplasm until IkappaB proteins are phosphorylated and degraded...
  6. ncbi request reprint Tumor antigen-specific T helper cells in cancer immunity and immunotherapy
    K L Knutson
    Department of Immunology, Mayo Clinic College of Medicine, 342C Guggenheim Bldg, 200 First St SW, Rochester, MN 55906, USA
    Cancer Immunol Immunother 54:721-8. 2005
    ....
  7. ncbi request reprint IL-2 immunotoxin therapy modulates tumor-associated regulatory T cells and leads to lasting immune-mediated rejection of breast cancers in neu-transgenic mice
    Keith L Knutson
    Department of Immunology, Mayo Clinic College of Medicine, 342C Guggenheim, 200 First Street SW, Rochester, MN 55905, USA
    J Immunol 177:84-91. 2006
    ....
  8. ncbi request reprint Strong-arming immune regulation: suppressing regulatory T-cell function to treat cancers
    Keith L Knutson
    Department of Immunology, Mayo Clinic College of Medicine, 342C Guggenheim, 200 First St SW, Mayo Clinic, Rochester, MN 55905, USA
    Future Oncol 2:379-89. 2006
    ..e., autoimmune disease). In this review, the biology of Tregs is discussed along with their involvement in malignancies and emerging strategies to block their function...
  9. ncbi request reprint Immunoediting of cancers may lead to epithelial to mesenchymal transition
    Keith L Knutson
    Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 177:1526-33. 2006
    ..Understanding the mechanisms by which tumors are immunoedited will likely lead to a better understanding of how tumors evade immune detection...
  10. ncbi request reprint Augmenting T helper cell immunity in cancer
    K L Knutson
    Department of Immunology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55906, USA
    Curr Drug Targets Immune Endocr Metabol Disord 5:365-71. 2005
    ..Over the next decade, studies should begin to further define how we can manipulate the Th immune effector arm to achieve effective antitumor immunity...
  11. ncbi request reprint T-cell immunity to the folate receptor alpha is prevalent in women with breast or ovarian cancer
    Keith L Knutson
    Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Clin Oncol 24:4254-61. 2006
    ..A candidate antigen is the folate receptor alpha (FRalpha), which is overexpressed in breast and ovarian cancers. Our goal in this study was to attain a better understanding of the extent of endogenous FRalpha immunity...
  12. ncbi request reprint Laboratory analysis of T-cell immunity
    Keith L Knutson
    Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Front Biosci 11:1932-44. 2006
    ..Informative immunologic monitoring of T cells will be one of the driving forces in advancing the field of tumor immunology...
  13. ncbi request reprint CD4 regulatory T cells in human cancer pathogenesis
    Keith L Knutson
    Department of Immunology, Mayo Clinic College of Medicine, Mayo Clinic, 342C Guggenheim, 200 First Street SW, Rochester, MN 55905, USA
    Cancer Immunol Immunother 56:271-85. 2007
    ..e., autoimmune disease). In this review, the biology of human CD4(+) Tregs is discussed along with their involvement in malignancies and emerging strategies to block their function...
  14. pmc Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cells
    Marta Santisteban
    Department of Oncology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer Res 69:2887-95. 2009
    ..These findings have several important implications related to disease progression and relapse...
  15. pmc An HLA-DR-degenerate epitope pool detects insulin-like growth factor binding protein 2-specific immunity in patients with cancer
    Kimberly R Kalli
    Departments of Oncology, Immunology, and Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA
    Cancer Res 68:4893-901. 2008
    ..All four peptides are naturally processed and presented to CD4 T-cells. The degenerate pool of peptides covers nearly 80% of patients and may be useful for augmenting CD4 T-cell immunity in patients undergoing immunization...
  16. pmc Intraepithelial effector (CD3+)/regulatory (FoxP3+) T-cell ratio predicts a clinical outcome of human colon carcinoma
    Frank A Sinicrope
    Miles and Shirley Fiterman Digestive Disease Center, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Gastroenterology 137:1270-9. 2009
    ..We investigated whether the intratumoral densities of FoxP3(+) and effector CD3(+) lymphocytes are associated with prognosis of patients with colon cancer...
  17. pmc A degenerate HLA-DR epitope pool of HER-2/neu reveals a novel in vivo immunodominant epitope, HER-2/neu88-102
    Lavakumar Karyampudi
    Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA
    Clin Cancer Res 16:825-34. 2010
    ..Our goal in this study was to identify broad coverage HLA-DR epitopes of HER-2/neu, an antigen that is highly expressed in a variety of carcinomas...
  18. pmc Immune promotion of epithelial-mesenchymal transition and generation of breast cancer stem cells
    Jennifer M Reiman
    Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA
    Cancer Res 70:3005-8. 2010
    ..These studies provide a window to understanding how BCSC arise and are maintained within tumors, and how to best target these processes for therapeutic benefit...
  19. pmc Analysis of complex biomarkers for human immune-mediated disorders based on cytokine responsiveness of peripheral blood cells
    John M Davis
    Division of Rheumatology, Department of Medicine, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 184:7297-304. 2010
    ..Thus, our approach lays the foundation for the development of immunologic "signatures" that could be useful in predicting disease course and monitoring the outcomes of therapy among patients with immune-mediated diseases...
  20. pmc Peptide vaccine given with a Toll-like receptor agonist is effective for the treatment and prevention of spontaneous breast tumors
    Pilar Nava-Parada
    Department of Immunology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Cancer Res 67:1326-34. 2007
    ..e., epitope spreading). These results suggest that similar strategies should be followed for conducting clinical studies in patients...
  21. pmc Casp8p41 expression in primary T cells induces a proinflammatory response
    Julie A Taylor
    Division of Infectious Diseases, Rochester, Minnesota, USA
    AIDS 24:1251-8. 2010
    ..Herein, we questioned whether Casp8p41-induced NFkappaB activation impacts the cytokine profile of cells expressing Casp8p41...
  22. pmc Identification of a broad coverage HLA-DR degenerate epitope pool derived from carcinoembryonic antigen
    Lavakumar Karyampudi
    Department of Immunology, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Cancer Immunol Immunother 59:161-71. 2010
    ..Patients with breast or ovarian cancer demonstrate pre-existent immune responses to the tumor antigen CEA. The degenerate pool of CEA peptides may be useful for augmenting CD4 T cell immunity...
  23. pmc Folate receptor alpha as a tumor target in epithelial ovarian cancer
    Kimberly R Kalli
    Division of Medical Oncology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Gynecol Oncol 108:619-26. 2008
    ..The goal of this study is to improve historical data that lack specific information about FRalpha expression in rare histological subtypes, primary disease versus metastatic foci, and recurrent disease...
  24. pmc Beneficial effect of TRAIL on HIV burden, without detectable immune consequences
    Brett D Shepard
    Mayo Clinic, Rochester, Minnesota, USA
    PLoS ONE 3:e3096. 2008
    ....
  25. ncbi request reprint Adoptive T cell therapy of solid cancers
    Keith L Knutson
    Mayo Clinic College of Medicine, 342D Guggenheim, 200 First St SW, Mayo Clinic, Rochester, MN 55905, USA
    Cancer Immunol Immunother 55:96-103. 2006
    ..Some of the major problems are sources of tumor-specific T cells, ex vivo expansion, persistence, and anti-tumor activity. This review overviews the nature of these problems and some of the emerging solutions...
  26. ncbi request reprint Tumor-infiltrating Foxp3-CD4+CD25+ T cells predict poor survival in renal cell carcinoma
    Sameer A Siddiqui
    Department of Urology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Clin Cancer Res 13:2075-81. 2007
    ..We tested for the presence of putative Tregs within renal cell carcinoma (RCC) tumors...
  27. pmc The endogenous danger signal, crystalline uric acid, signals for enhanced antibody immunity
    Marshall D Behrens
    Department of Immunology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Blood 111:1472-9. 2008
    ..Understanding the nature of endogenous danger signals released from dying cells may aid in a better understanding of mechanisms of immune recognition of self...
  28. pmc Tumor immunoediting and immunosculpting pathways to cancer progression
    Jennifer M Reiman
    Department of Immunology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, United States
    Semin Cancer Biol 17:275-87. 2007
    ..Regardless, these immune-induced alterations could contribute to cancer pathogenesis. Understanding the mechanisms by which tumors evade immunity will be important for disease prevention and therapeutics...
  29. ncbi request reprint Induction of a Th1 response from Th2-polarized T cells by activated dendritic cells: dependence on TCR:peptide-MHC interaction, ICAM-1, IL-12, and IFN-gamma
    Suresh Radhakrishnan
    Department of Immunology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    J Immunol 178:3583-92. 2007
    ..Because the regulation of mouse and human DC by B7-DC XAb overlaps in several significant ways, immune modulation with B7-DC XAb is a potential strategy for treating Th2-mediated diseases...
  30. pmc Renal hemodynamic, inflammatory, and apoptotic responses to lipopolysaccharide in HO-1-/- mice
    Michal J Tracz
    Division of Nephrology and Hypertension, Department of Pathology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Am J Pathol 170:1820-30. 2007
    ..Because polymorphisms in the HO-1 gene with diminished HO activity predispose to human disease, we speculate that our findings may be relevant to the clinical outcome in patients with sepsis syndromes...
  31. ncbi request reprint Immunotherapy for breast cancer
    Keith L Knutson
    Tumor Vaccine Group, University of Washington, Seattle, WA, USA
    Cancer Chemother Biol Response Modif 20:351-69. 2002
  32. ncbi request reprint Tumor antigen-specific T-cell expansion is greatly facilitated by in vivo priming
    Yushe Dang
    Tumor Vaccine Group, Center for Translational Medicine in Women s Health, University of Washington, Seattle, WA 98109, USA
    Clin Cancer Res 13:1883-91. 2007
    ..In this study, we evaluated the feasibility of expanding HER-2/neu-specific T cells derived from peripheral blood ex vivo following in vivo priming with a HER-2/neu peptide vaccine...
  33. pmc Signatures associated with rejection or recurrence in HER-2/neu-positive mammary tumors
    Andrea Worschech
    Department of Microbiology and Immunology, Virginia Commonwealth University School of Medicine, Massey Cancer Center, Richmond, VA 23298, USA
    Cancer Res 68:2436-46. 2008
    ..These data provide a road map for the identification of novel biomarkers of immune responsiveness in clinical trials...
  34. pmc HER-2/neu antigen loss and relapse of mammary carcinoma are actively induced by T cell-mediated anti-tumor immune responses
    Maciej Kmieciak
    Department of Microbiology and Immunology, VCU School of Medicine, Massey Cancer Center, Richmond, VA 23298, USA
    Eur J Immunol 37:675-85. 2007
    ..This appears to be due to methylation of the neu promoter. Together, these data suggest that neu antigen loss is an active process that occurs in primary tumors due to the neu-targeted anti-tumor immune responses...
  35. ncbi request reprint The tumor antigen repertoire identified in tumor-bearing neu transgenic mice predicts human tumor antigens
    Hailing Lu
    Tumor Vaccine Group, Center for Translational Medicine in Women s Health, University of Washington, Seattle, WA 98195, USA
    Cancer Res 66:9754-61. 2006
    ..Our results indicate that neu-tg mice bearing spontaneous tumors develop humoral immunity to their tumors similar to cancer patients and that tumor antigens identified in transgenic mouse may predict immunogenic human homologues...
  36. ncbi request reprint Plasmid-based vaccines encoding rat neu and immune stimulatory molecules can elicit rat neu-specific immunity
    Mary L Disis
    Tumor Vaccine Group, Division of Oncology, University of Washington, Seattle, WA 98195 6527, USA
    Mol Cancer Ther 2:995-1002. 2003
    ..DNA vaccines encoding neu, when given in combination with both CD137L and either CD80 or CD86, can induce cellular and humoral immunity and result in an antitumor effect...
  37. ncbi request reprint Immunologic principles and immunotherapeutic approaches in ovarian cancer
    Keith L Knutson
    Tumor Vaccine Group, 1959 Northeast Pacific Street, Box 356527, HSB BB1321, University of Washington, Seattle, WA 98195, USA
    Hematol Oncol Clin North Am 17:1051-73. 2003
    ..It is hoped that discoveries at the bench along with lessons learned in prior clinical trials soon will allow clinicians to develop rationally based immunologic strategies to treat and prevent ovarian cancer...
  38. ncbi request reprint Soluble cytokines can act as effective adjuvants in plasmid DNA vaccines targeting self tumor antigens
    Mary L Disis
    Division of Oncology, University of Washington, Seattle, Washington 98195 6527, USA
    Immunobiology 207:179-86. 2003
    ..Antibodies directed against rat neu were not elicited with this approach, indicating that the neu specific T cell immune response elicited with plasmid DNA was skewed towards cell-mediated rather than humoral immunity...
  39. ncbi request reprint Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity
    Tyler J Curiel
    Tulane University Health Science Center, New Orleans, Louisiana, USA
    Nat Med 9:562-7. 2003
    ..Therefore, upregulation of B7-H1 on MDCs in the tumor microenvironment downregulates T-cell immunity. Blockade of B7-H1 represents one approach for cancer immunotherapy...
  40. ncbi request reprint Clonal diversity of the T-cell population responding to a dominant HLA-A2 epitope of HER-2/neu after active immunization in an ovarian cancer patient
    Keith L Knutson
    Division of Oncology, Department of Medicine, University of Washington, Seattle, WA 98195 6527, USA
    Hum Immunol 63:547-57. 2002
    ..These results suggest that a tumor antigen TCR, directed against a specific epitope, can be markedly polyclonal at multiple levels including CD4/CD8 and TCR...
  41. ncbi request reprint Generation of T-cell immunity to the HER-2/neu protein after active immunization with HER-2/neu peptide-based vaccines
    Mary L Disis
    Division of Oncology and Department of Dermatology, University of Washington, Seattle 98195 6527, USA
    J Clin Oncol 20:2624-32. 2002
    ....
  42. ncbi request reprint Immunization of cancer patients with a HER-2/neu, HLA-A2 peptide, p369-377, results in short-lived peptide-specific immunity
    Keith L Knutson
    Division of Oncology, University of Washington, Seattle 98195 6527, USA
    Clin Cancer Res 8:1014-8. 2002
    ..However, the magnitude of the responses were low, as well as short-lived, suggesting that CD4+ T-cell help is required for lasting immunity to this epitope...
  43. ncbi request reprint Flt3 ligand as a vaccine adjuvant in association with HER-2/neu peptide-based vaccines in patients with HER-2/neu-overexpressing cancers
    Mary L Disis
    Division of Oncology, University of Washington, Seattle, WA 98195 6527, USA
    Blood 99:2845-50. 2002
    ..Finally, vaccine regimens including FL as a vaccine adjuvant were associated with the development of apparent autoimmune phenomena in some patients...
  44. ncbi request reprint Immunization of cancer patients with HER-2/neu-derived peptides demonstrating high-affinity binding to multiple class II alleles
    Lupe G Salazar
    Tumor Vaccine Group, Division of Oncology, University of Washington, Seattle, Washington, USA
    Clin Cancer Res 9:5559-65. 2003
    ..Furthermore, we questioned whether MHC binding affinity could predict the in vivo immunogenicity of the HER-2/neu helper peptides...
  45. ncbi request reprint Neu antigen-negative variants can be generated after neu-specific antibody therapy in neu transgenic mice
    Keith L Knutson
    University of Washington, Tumor Vaccine Group, Department of Oncology, Seattle, Washington, USA
    Cancer Res 64:1146-51. 2004
    ....
  46. ncbi request reprint Effect of dose on immune response in patients vaccinated with an her-2/neu intracellular domain protein--based vaccine
    Mary L Disis
    Tumor Vaccine Group, Oncology, University of Washington, Seattle, WA 98195 6527, USA
    J Clin Oncol 22:1916-25. 2004
    ..To evaluate the safety of an HER-2/neu intracellular domain (ICD) protein vaccine and to estimate whether vaccine dose impacts immunogenicity...
  47. ncbi request reprint Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    Tyler J Curiel
    Tulane University Health Science Center, New Orleans, Louisiana 70112, USA
    Nat Med 10:942-9. 2004
    ..This specific recruitment of T(reg) cells represents a mechanism by which tumors may foster immune privilege. Thus, blocking T(reg) cell migration or function may help to defeat human cancer...
  48. ncbi request reprint HER-2/neu vaccines
    Mary L Disis
    University of Washington, Seattle 98195 6527, USA
    Cancer Chemother Biol Response Modif 21:275-85. 2003
  49. ncbi request reprint Humoral epitope-spreading following immunization with a HER-2/neu peptide based vaccine in cancer patients
    Mary L Disis
    Tumor Vaccine Group, Division of Oncology, University of Washington, Seattle, Washington 98195 6527, USA
    J Clin Immunol 24:571-8. 2004
    ..Intermolecular epitope-spreading to p53 was evident in 20% of vaccinated patients. Of those patients who developed new immunity to p53, 71% had demonstrated antibody epitope-spreading within HER-2/neu...
  50. ncbi request reprint Emergence of immune escape variant of mammary tumors that has distinct proteomic profile and a reduced ability to induce "danger signals"
    Masoud H Manjili
    Department of Microbiology and Immunology, Virginia Commonwealth University, Massey Cancer Center, Richmond, VA, 23298, USA
    Breast Cancer Res Treat 96:233-41. 2006
    ..Based on these findings, we propose to target novel antigens over-expressed in the escape variant of breast tumors to treat primary tumor and to prevent tumor relapse...
  51. ncbi request reprint Antitumor efficacy of CD137 ligation is maximized by the use of a CD137 single-chain Fv-expressing whole-cell tumor vaccine compared with CD137-specific monoclonal antibody infusion
    Hongtao Zhang
    Department of Pathology, Center for Translational Medicine in Women s Health, University of Washington, Seattle, USA
    Mol Cancer Ther 5:149-55. 2006
    ..In contrast, repeated administration of either of two different anti-CD137 monoclonal antibodies did not induce complete tumor regression, although tumor growth was delayed...
  52. ncbi request reprint Tumor cells transduced with the MHC class II Transactivator and CD80 activate tumor-specific CD4+ T cells whether or not they are silenced for invariant chain
    James A Thompson
    Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD 21250, USA
    Cancer Res 66:1147-54. 2006
    ..Therefore, tumor cells transduced with the CIITA, CD80, and with or without Ii siRNA present endogenously synthesized tumor antigens and are potential vaccines for activating tumor-specific CD4+ T cells...
  53. ncbi request reprint GMK (Progenics Pharmaceuticals)
    Keith L Knutson
    University of Washington, Tumor Vaccine Group, Seattle, 98195, USA
    Curr Opin Investig Drugs 3:159-64. 2002
    ..In July 2001, Ladenburg Thalmann predicted a $257 million market potential for GMK in the US, with the non-US market equivalent to the US market. A launch date of 2005 in the US, with a worldwide launch in 2006, was estimated [433347]...
  54. ncbi request reprint Peptide-based vaccines in breast cancer
    Mary L Disis
    Tumor Vaccine Group, Oncology, University of Washington, Seattle, WA 98195 6527, USA
    Breast Dis 20:3-11. 2004
    ..Peptide based vaccines are one of the most commonly studied vaccine strategies targeting breast cancer...
  55. ncbi request reprint Technology evaluation: DCVax, Northwest Biotherapeutics
    Keith L Knutson
    University of Washington, Tumor Vaccine Group, Seattle 98195, USA
    Curr Opin Mol Ther 4:403-7. 2002
    ..DCVax-Brain is currently undergoing phase II clinical trials, and DCVax-Lung recently received approval from the US FDA for phase I clinical trials...
  56. ncbi request reprint Augmented HER-2 specific immunity during treatment with trastuzumab and chemotherapy
    Clare Taylor
    Department of Microbiology, College of Physicians and Surgeons, Columbia University, New York, NY 10027 6902, USA
    Clin Cancer Res 13:5133-43. 2007
    ..We have assessed whether immune sensitization to the HER-2/neu tumor antigen occurs during treatment with the anti-HER-2/neu monoclonal antibody trastuzumab...
  57. ncbi request reprint Adoptive T-cell therapy for the treatment of solid tumours
    Keith L Knutson
    Division of Oncology, University of Washington, 1959 NE Pacific Street, HSB BB1321, Box 356527, Seattle, WA 98195 6527, USA
    Expert Opin Biol Ther 2:55-66. 2002
    ..In addition, advanced imaging techniques, such as positron emission tomography (PET), are being implemented in order to better define the in vivo function of ex vivo expanded tumour-specific T-cells...

Research Grants9

  1. HLA classl complex expression in breast cancer immunity
    Keith Knutson; Fiscal Year: 2006
    ..The results will likely lead to the identification of specific molecule associated with antigen presentation that could be either a novel therapeutic target or biomarker of disease outcome. ..
  2. HLA class l complex expression in breast cancer immunity
    Keith Knutson; Fiscal Year: 2005
    ..The results will likely lead to the identification of specific molecule associated with antigen presentation that could be either a novel therapeutic target or biomarker of disease outcome. ..
  3. Tumor rejection antigens induced via epitope spreading
    Keith Knutson; Fiscal Year: 2004
    ..Our goal is to develop immune-based strategies (e.g. vaccines) that would be associated with tumor destruction and survival benefit. ..
  4. HLA class l complex expression in breast cancer immunity
    Keith Knutson; Fiscal Year: 2007
    ..The results will likely lead to the identification of specific molecule associated with antigen presentation that could be either a novel therapeutic target or biomarker of disease outcome. ..
  5. Ex vivo expansion of HER-2/neu specific T helper cells
    Keith Knutson; Fiscal Year: 2007
    ..abstract_text> ..
  6. Analysis of serum folate receptor and antibody level for ovarian cancer detection
    Keith Knutson; Fiscal Year: 2007
    ....
  7. HLA classl complex expression in breast cancer immunity
    Keith Knutson; Fiscal Year: 2009
    ..The results will likely lead to the identification of specific molecule associated with antigen presentation that could be either a novel therapeutic target or biomarker of disease outcome. ..