George G Klee

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. doi request reprint Mass Spectrometry Measurements of Prostate-Specific Antigen (PSA) Peptides Derived From Immune-Extracted PSA Provide a Potential Strategy for Harmonizing Immunoassay Differences
    Eric W Klee
    Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905
    Am J Clin Pathol 141:527-33. 2014
  2. ncbi request reprint Clinical usage recommendations and analytic performance goals for total and free triiodothyronine measurements
    G G Klee
    Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Clin Chem 42:155-9. 1996
  3. ncbi request reprint Clinical interpretation of reference intervals and reference limits. A plea for assay harmonization
    George G Klee
    Department of Laboratory Medicine and Pathology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Clin Chem Lab Med 42:752-7. 2004
  4. ncbi request reprint MUC1 gene-derived glycoprotein assays for monitoring breast cancer (CA 15-3, CA 27.29, BR): are they measuring the same antigen?
    George G Klee
    Department of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, Rochester, Minn 55905, USA
    Arch Pathol Lab Med 128:1131-5. 2004
  5. ncbi request reprint Effects of analytic variations in creatinine measurements on the classification of renal disease using estimated glomerular filtration rate (eGFR)
    George G Klee
    Department of Laboratory Medicine and Pathology, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Clin Chem Lab Med 45:737-41. 2007
  6. ncbi request reprint Cobalamin and folate evaluation: measurement of methylmalonic acid and homocysteine vs vitamin B(12) and folate
    G G Klee
    Department of Laboratory Medicine and Pathology, Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Clin Chem 46:1277-83. 2000
  7. ncbi request reprint Analytic bias specifications based on the analysis of effects on performance of medical guidelines
    G G Klee
    Department of Laboratory Medicine and Pathology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Scand J Clin Lab Invest 59:509-12. 1999
  8. ncbi request reprint Highly sensitive automated chemiluminometric assay for measuring free human glandular kallikrein-2
    G G Klee
    Departments of Laboratory Medicine and Pathology, Epidemiology, and Urology Research, Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Clin Chem 45:800-6. 1999
  9. doi request reprint Establishment of outcome-related analytic performance goals
    George G Klee
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Clin Chem 56:714-22. 2010
  10. ncbi request reprint Interferences in hormone immunoassays
    George G Klee
    Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, MN 55905, USA
    Clin Lab Med 24:1-18. 2004

Detail Information

Publications61

  1. doi request reprint Mass Spectrometry Measurements of Prostate-Specific Antigen (PSA) Peptides Derived From Immune-Extracted PSA Provide a Potential Strategy for Harmonizing Immunoassay Differences
    Eric W Klee
    Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905
    Am J Clin Pathol 141:527-33. 2014
    ..Conclusions: Mass spectrometry quantitation of peptides derived from trypsin digestion of immune-extracted PSA could be used to harmonize PSA immunoassays. ..
  2. ncbi request reprint Clinical usage recommendations and analytic performance goals for total and free triiodothyronine measurements
    G G Klee
    Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Clin Chem 42:155-9. 1996
    ..Analytic recommendations include CV < 5.2% for T3 and < 3.8% for FT3; < 0.2% cross-reactivity with L-T4; and < 1.0% cross-reactivity with D-T4, D-T3, and reverse T3...
  3. ncbi request reprint Clinical interpretation of reference intervals and reference limits. A plea for assay harmonization
    George G Klee
    Department of Laboratory Medicine and Pathology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Clin Chem Lab Med 42:752-7. 2004
    ..Both univariate and multivariate reference intervals are discussed. Model systems for using disease prevalence and cost utility functions are provided to illustrate optimization of medical decisions...
  4. ncbi request reprint MUC1 gene-derived glycoprotein assays for monitoring breast cancer (CA 15-3, CA 27.29, BR): are they measuring the same antigen?
    George G Klee
    Department of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, Rochester, Minn 55905, USA
    Arch Pathol Lab Med 128:1131-5. 2004
    ..These 2 types of assays measure slightly different parts of this tandem-repeat molecule. Across-method assay differences hinder the exchange of patient test values among integrated health care networks and among countries...
  5. ncbi request reprint Effects of analytic variations in creatinine measurements on the classification of renal disease using estimated glomerular filtration rate (eGFR)
    George G Klee
    Department of Laboratory Medicine and Pathology, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Clin Chem Lab Med 45:737-41. 2007
    ..The equation was inverted to provide critical creatinine levels corresponding to eGFRs equal to 15, 30, and 60 mL/min/1.73 m(2)...
  6. ncbi request reprint Cobalamin and folate evaluation: measurement of methylmalonic acid and homocysteine vs vitamin B(12) and folate
    G G Klee
    Department of Laboratory Medicine and Pathology, Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Clin Chem 46:1277-83. 2000
    ....
  7. ncbi request reprint Analytic bias specifications based on the analysis of effects on performance of medical guidelines
    G G Klee
    Department of Laboratory Medicine and Pathology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Scand J Clin Lab Invest 59:509-12. 1999
    ..The +/-10% bias ranges for PSA correspond to -19.9% to +20.4% variation in patient classification. The larger tolerance limits of the CLIA-88 standards for proficiency testing would cause even wider variations in patient classifications...
  8. ncbi request reprint Highly sensitive automated chemiluminometric assay for measuring free human glandular kallikrein-2
    G G Klee
    Departments of Laboratory Medicine and Pathology, Epidemiology, and Urology Research, Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Clin Chem 45:800-6. 1999
    ..Methods: We developed an automated assay for hK2 with use of a select pair of monoclonal antibodies. The prototype assay was implemented on a Beckman Coulter ACCESS(R) analyzer...
  9. doi request reprint Establishment of outcome-related analytic performance goals
    George G Klee
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Clin Chem 56:714-22. 2010
    ....
  10. ncbi request reprint Interferences in hormone immunoassays
    George G Klee
    Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, MN 55905, USA
    Clin Lab Med 24:1-18. 2004
    ..The simple steps to test for dilutional linearity, spiked recovery, heterophile antibody blocking,and testing with alternate technology can help in the evaluations of cases that are suspected to have assay interference...
  11. pmc Associations between longitudinal changes in serum estrogen, testosterone, and bioavailable testosterone and changes in benign urologic outcomes
    Jennifer L St Sauver
    Division of Epidemiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Am J Epidemiol 173:787-96. 2011
    ..These results suggest that both absolute sex steroid hormone levels and the rates at which the levels change may be important in the development of urologic conditions in aging men...
  12. pmc The associations between serum sex hormones, erectile function, and sex drive: the Olmsted County Study of Urinary Symptoms and Health Status among Men
    Naomi M Gades
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, USA
    J Sex Med 5:2209-20. 2008
    ..Testosterone replacement therapy has been used in the treatment of sexual dysfunction; however, its use remains controversial, and the effectiveness and long-term health implications are unknown...
  13. pmc Sex and ethnic differences in 47 candidate proteomic markers of cardiovascular disease: the Mayo Clinic proteomic markers of arteriosclerosis study
    Charles X Kim
    Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 5:e9065. 2010
    ..We examined differences in circulating levels of 47 novel protein markers of CVD in 2561 men and women of African-American (AA) and non-Hispanic White (NHW) ethnicity, enrolled at geographically distinct sites...
  14. pmc A tissue biomarker panel predicting systemic progression after PSA recurrence post-definitive prostate cancer therapy
    Tohru Nakagawa
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 3:e2318. 2008
    ..We hypothesized that an expression biomarker panel can predict which men with a rising PSA would benefit from further therapy...
  15. ncbi request reprint LC-MS/MS quantification of Zn-alpha2 glycoprotein: a potential serum biomarker for prostate cancer
    Olga P Bondar
    Department of Laboratory Medicine and Pathology, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Clin Chem 53:673-8. 2007
    ..We present a high-flow liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for measuring serum ZAG concentrations by proteolytic cleavage of the protein and quantification of a unique peptide...
  16. pmc Immunological and mass spectrometric assays of SHBG: consistent and inconsistent metabolic associations in healthy men
    Johannes D Veldhuis
    Endocrine Research Unit J D V, Mayo School of Graduate Medical Education Center for Translational Science Activities, Immunochemical Laboratory R B D, and Departments of Neurology S A T and Laboratory Medicine and Pathology J D V, O P B, E W K, R J S, G G K, Mayo Clinic, Rochester, Minnesota 55905
    J Clin Endocrinol Metab 99:184-93. 2014
    ..SHBG concentrations correlate inconsistently with metabolic parameters...
  17. pmc Associations of candidate biomarkers of vascular disease with the ankle-brachial index and peripheral arterial disease
    Zi Ye
    Division of Cardiovascular Diseases and the Gonda Vascular Center, Mayo Clinic, Rochester, MN, USA
    Am J Hypertens 26:495-502. 2013
    ..To this end, we investigated associations of 47 candidate biomarkers with the ABI and presence of peripheral arterial disease (PAD) in African-Americans (AAs) and non-Hispanic whites (NHWs)...
  18. ncbi request reprint Serum sex hormones and measures of benign prostatic hyperplasia
    Rosebud O Roberts
    Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Prostate 61:124-31. 2004
    ..Despite biologic plausibility, the associations between sex hormones and measures of benign prostatic hyperplasia (BPH) have not been consistently reported...
  19. pmc Antibody-based protein multiplex platforms: technical and operational challenges
    Allison A Ellington
    Division of Cardiovascular Diseases, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Clin Chem 56:186-93. 2010
    ..This concept has stimulated development of multiplexed immunoassay platforms that provide multiple, parallel protein measurements on the same specimen...
  20. ncbi request reprint Association of plasma resistin with glomerular filtration rate and albuminuria in hypertensive adults
    Allison A Ellington
    Division of Cardiovascular Diseases, Mayo Clinic, 200 First St Southwest, Rochester, MN 55905, USA
    Hypertension 50:708-14. 2007
    ..This association was independent of coronary heart disease risk factors and markers of insulin resistance and inflammation...
  21. doi request reprint Candidate serum biomarkers for prostate adenocarcinoma identified by mRNA differences in prostate tissue and verified with protein measurements in tissue and blood
    Eric W Klee
    Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA
    Clin Chem 58:599-609. 2012
    ....
  22. ncbi request reprint Bioinformatics methods for prioritizing serum biomarker candidates
    Eric W Klee
    Mayo Clinic, 315 Stabile Building, Rochester, MN 55904, USA
    Clin Chem 52:2162-4. 2006
  23. pmc Measurement and quality control issues in multiplex protein assays: a case study
    Allison A Ellington
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA
    Clin Chem 55:1092-9. 2009
    ..Here, we use measurements of 15 protein biomarkers from a large study to illustrate processing, analytic, and quality control issues with multiplexed immunoassays...
  24. ncbi request reprint Factors influencing clinical decisions to initiate thyroxine therapy for patients with mildly increased serum thyrotropin (5.1-10.0 mIU/L)
    Vahab Fatourechi
    Division of Endocrinology, Diabetes, Metabolism, Nutrition and Internal Medicine, Mayo Clinic, Rochester, Minn 55905, USA
    Mayo Clin Proc 78:554-60. 2003
    ..To determine factors that influence clinicians' decisions to treat subclinical hypothyroidism...
  25. doi request reprint Validation of a genomic classifier that predicts metastasis following radical prostatectomy in an at risk patient population
    R Jeffrey Karnes
    Department of Urology, Mayo Clinic, Rochester, Minnesota Electronic address
    J Urol 190:2047-53. 2013
    ..We report a validation study of a genomic classifier that predicts metastasis after radical prostatectomy in a high risk population...
  26. ncbi request reprint Phase 1 study of interleukin-12 in combination with rituximab in patients with B-cell non-Hodgkin lymphoma
    Stephen M Ansell
    Division of Hematology, Mayo Clinic, Rochester, MN 55905, USA
    Blood 99:67-74. 2002
    ..These data suggest that IL-12 and rituximab is an active combination and further studies of this combination in B-cell non-Hodgkin lymphoma are warranted...
  27. ncbi request reprint Investigating the utility of serum cytokine measurements in a multi-institutional cancer anorexia/weight loss trial
    Aminah Jatoi
    Mayo Clinic and Mayo Foundation, 200 First Street, SW, Rochester, MN 55905, USA
    Support Care Cancer 12:640-4. 2004
    ..As the translational component of a large multi-institutional trial, this study assessed the clinical value of serum concentrations of these cytokines in patients with this syndrome...
  28. ncbi request reprint Neuropeptide Y, leptin, and cholecystokinin 8 in patients with advanced cancer and anorexia: a North Central Cancer Treatment Group exploratory investigation
    A Jatoi
    Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Cancer 92:629-33. 2001
    ..Anorexia is a noxious symptom, and over half of patients with advanced cancer experience it. Neuropeptide Y (NPY), leptin, and cholecystokinin 8 (CCK8) have been implicated...
  29. ncbi request reprint Measurement of blood volume and red cell mass: re-examination of 51Cr and 125I methods
    V F Fairbanks
    Department of Laboratory Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Blood Cells Mol Dis 22:169-86; discussion 186a-186g. 1996
    ..No cases of "stress erythrocytosis" or Gaisbock Syndrome were encountered among the 119 cases reviewed...
  30. ncbi request reprint Islet amyloid polypeptide is not a satisfactory marker for detecting pancreatic cancer
    S T Chari
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Gastroenterology 121:640-5. 2001
    ....
  31. ncbi request reprint Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: a key role for bioavailable estrogen
    S Khosla
    Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 83:2266-74. 1998
    ..These studies suggest that in contrast to traditional belief, age-related bone loss may be the result of E deficiency not just in postmenopausal women, but also in men...
  32. ncbi request reprint Phase I study of the matrix metalloproteinase inhibitor, BAY 12-9566
    C Erlichman
    Mayo Clinic Cancer Center, Rochester, Minnesota, USA
    Ann Oncol 12:389-95. 2001
    ..We undertook a phase I study of BAY 12-9566, an inhibitor of MMP-2, MMP-9, and MMP-3, in patients with solid tumors to determine its safety, pharmacokinetics, and effects on potential surrogate markers of biologic activity...
  33. ncbi request reprint Effects of changing diagnostic criteria on the risk of developing diabetes
    S F Dinneen
    Division of Endocrinology and Metabolism, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Diabetes Care 21:1408-13. 1998
    ..8 mmol/l (the level recommended by the National Diabetes Data Group [NDDG] in 1979) to 7.0 mmol/l. We examined the impact of this change on rates of progression to overt diabetes from different levels of FPG...
  34. doi request reprint Analytical performance specifications: relating laboratory performance to quality required for intended clinical use
    Daniel A Dalenberg
    Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
    Clin Lab Med 33:55-73. 2013
    ..Goals for consistency are derived from the variability of distributions of patient test values. Data were collected and evaluated for each of these quality indicators for 46 chemistry tests measured on the Roche cobas 8000 analyzer...
  35. pmc Adrenomedullin is up-regulated in patients with pancreatic cancer and causes insulin resistance in β cells and mice
    Gaurav Aggarwal
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Gastroenterology 143:1510-1517.e1. 2012
    ..New-onset diabetes in patients with pancreatic cancer is likely to be a paraneoplastic phenomenon caused by tumor-secreted products. We aimed to identify the diabetogenic secretory product(s) of pancreatic cancer...
  36. doi request reprint Global methylation profiling for risk prediction of prostate cancer
    Saswati Mahapatra
    Department of Urology and Laboratory Medicine and Pathology, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota 55905, USA
    Clin Cancer Res 18:2882-95. 2012
    ..The aim of this study was to investigate the promoter hypermethylation as diagnostic markers to detect malignant prostate cells and as prognostic markers to predict the clinical recurrence of prostate cancer...
  37. ncbi request reprint Lack of association between plasma homocysteine and angiographic coronary artery disease in the era of fortification of cereal grain flour with folic acid
    Emmanouil S Brilakis
    Division of Cardiovascular Diseases W16, Department of Internal Medicine, Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Atherosclerosis 165:375-81. 2002
    ..The homocysteine-lowering effect of folate-fortified flour, or the inclusion of many traditional and emerging risk factors in multivariate analysis, are potential explanations...
  38. ncbi request reprint Cytokine production patterns and antibody response to measles vaccine
    Inna G Ovsyannikova
    Department of Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Vaccine 21:3946-53. 2003
    ..There was no correlation between cytokine production by PBMC supernatants after PHA stimulation and circulating levels of plasma cytokines. No relationship was found between any specific cytokine level and measles antibody level...
  39. ncbi request reprint Human glandular kallikrein 2 (hK2) expression in prostatic intraepithelial neoplasia and adenocarcinoma: a novel prostate cancer marker
    M F Darson
    Department of Urology, Mayo Clinic, Rochester, MN 35905, USA
    Urology 49:857-62. 1997
    ..We describe the expression of a potentially new tumor marker, human glandular kallikrein 2 (hK2), that may be useful as an adjunct to prostate-specific antigen (PSA) in the diagnosis and monitoring of prostate cancer...
  40. ncbi request reprint Absolute quantification of the model biomarker prostate-specific antigen in serum by LC-Ms/MS using protein cleavage and isotope dilution mass spectrometry
    David R Barnidge
    W M Keck FT ICR Mass Spectrometry Laboratory, Mayo Proteomics Research Center, Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Proteome Res 3:644-52. 2004
    ..However, concerns still exist regarding sensitivity compared to existing immunoassays as well as the reproducibility of PC-IDMS performed in different matrixes...
  41. ncbi request reprint DHEA in elderly women and DHEA or testosterone in elderly men
    K Sreekumaran Nair
    Division of Endocrinology, Mayo Clinic, Rochester, MN 55905, USA
    N Engl J Med 355:1647-59. 2006
    ..Dehydroepiandrosterone (DHEA) and testosterone are widely promoted as antiaging supplements, but the long-term benefits, as compared with potential harm, are unknown...
  42. ncbi request reprint Symptomatic hyperthyroidism in a patient taking the dietary supplement tiratricol
    Brent A Bauer
    Division of Area General Internal Medicine, Mayo Clinic, Rochester, Minn 55905, USA
    Mayo Clin Proc 77:587-90. 2002
    ..The availability of such products on the Internet increases the already complex task of monitoring patients' use of dietary supplements...
  43. ncbi request reprint Insulin-like growth factor I, insulin-like growth factor binding protein 3, and urologic measures of benign prostatic hyperplasia
    Rosebud O Roberts
    Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester, MN 55905, USA
    Am J Epidemiol 157:784-91. 2003
    ..72, 95% CI: 1.05, 2.82), after simultaneous adjustment for IGF-I and age, but not with other urologic measures. These data do not provide evidence for an association between benign prostatic hyperplasia and serum IGF-I...
  44. pmc Optimization of laser capture microdissection and RNA amplification for gene expression profiling of prostate cancer
    Dagmar M Kube
    Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    BMC Mol Biol 8:25. 2007
    ..Here we present methods developed, optimized, and validated to obtain high quality gene expression data...
  45. ncbi request reprint Lack of association between lipoprotein(a) and coronary artery calcification in the Genetic Epidemiology Network of Arteriopathy (GENOA) study
    Iftikhar J Kullo
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Mayo Clin Proc 79:1258-63. 2004
    ..To investigate the relationship between lipoprotein(a) [Lp(a)] levels and the extent of coronary atherosclerosis in a cohort that consisted predominantly of hypertensive patients...
  46. pmc FAVL elevation in human tumors disrupts Fanconi anemia pathway signaling and promotes genomic instability and tumor growth
    Jun Zhang
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Invest 120:1524-34. 2010
    ..We further believe that these data will prove useful for developing additional tools for fighting human cancer...
  47. ncbi request reprint Mechanisms of the age-associated deterioration in glucose tolerance: contribution of alterations in insulin secretion, action, and clearance
    Rita Basu
    Endocrine Research Unit, Mayo Medical School, Rochester, Minnesota, USA
    Diabetes 52:1738-48. 2003
    ....
  48. ncbi request reprint Considerations on development, validation, application, and quality control of immuno(metric) biomarker assays in clinical cancer research: an EORTC-NCI working group report
    Fred C G J Sweep
    Department of Chemical Endocrinology, University Medical Center Nijmegen, NL 6500 HB Nijmegen, The Netherlands
    Int J Oncol 23:1715-26. 2003
    ..Moreover, a model for an appropriate quality assurance program is presented...
  49. ncbi request reprint A systematic method for selection of promising serum protein biomarkers to improve prostate cancer (PCa1) detection
    Judith A Finlay
    Invitrogen Corporation, 5781 Van Allen Way, Carlsbad, CA 92008, USA
    Clin Chem 52:2159-62. 2006
  50. ncbi request reprint Sex-specific associations of lipoprotein(a) with presence and quantity of coronary artery calcification in an asymptomatic population
    Andrea E Cassidy
    Department of Epidemiology, University of Michigan, Ann Arbor, Michigan 47104 3028, USA
    Med Sci Monit 10:CR493-503. 2004
    ..The relationship between serum Lp(a) and coronary artery calcification (CAC), a measure of subclinical coronary artery atherosclerosis, has not been extensively explored...
  51. ncbi request reprint Comparison of fresh frozen serum to proficiency testing material in College of American Pathologists surveys: alpha-fetoprotein, carcinoembryonic antigen, human chorionic gonadotropin, and prostate-specific antigen
    William E Schreiber
    Department of Pathology, Vancouver General Hospital, Vancouver, British Columbia, Canada
    Arch Pathol Lab Med 129:331-7. 2005
    ..We hypothesized that matrix effects would be reduced by using fresh frozen serum (FFS)...
  52. ncbi request reprint Development and validation of an automated chemiluminometric immunoassay for human intrinsic factor antibodies in serum
    Elizabeth A Gomez
    Beckman Coulter Inc, Chaska, MN, USA
    Clin Chem 51:232-5. 2005
  53. ncbi request reprint Comparison of pooled fresh frozen serum to proficiency testing material in College of American Pathologists surveys: cortisol and immunoglobulin E
    Darryl Erik Palmer-Toy
    Department of Pathology, Massachusetts General Hospital and Harvard Partners Center for Genetics and Genomics, Boston, Mass, USA
    Arch Pathol Lab Med 129:305-9. 2005
    ..The College of American Pathologists (CAP) provides proficiency testing (PT) surveys to laboratories around the world...
  54. ncbi request reprint Analytic bias of thyroid function tests: analysis of a College of American Pathologists fresh frozen serum pool by 3900 clinical laboratories
    Bernard W Steele
    Department of Pathology, University of Miami School of Medicine, Miami, Fla, USA
    Arch Pathol Lab Med 129:310-7. 2005
    ..In proficiency testing surveys, there are differences in the values reported by users of various analytic methods. Two contributors to this variation are calibrator bias and matrix effects of proficiency testing materials...
  55. ncbi request reprint Total long-term within-laboratory precision of cortisol, ferritin, thyroxine, free thyroxine, and thyroid-stimulating hormone assays based on a College of American Pathologists fresh frozen serum study: do available methods meet medical needs for precisio
    Bernard W Steele
    Department of Pathology, University of Miami School of Medicine, Miami, Fla, USA
    Arch Pathol Lab Med 129:318-22. 2005
    ..It is important that the total long-term precision of laboratory methods meet the medical needs of the patients being served...
  56. ncbi request reprint Comparison of fresh frozen serum to traditional proficiency testing material in a College of American Pathologists survey for ferritin, folate, and vitamin B12
    Jay L Bock
    Department of Pathology, Stony Brook University, Stony Brook, NY 11794 7300, USA
    Arch Pathol Lab Med 129:323-7. 2005
    ..Comparison of different analytical methods in proficiency surveys may be affected by the artificial nature of the survey material...
  57. ncbi request reprint A comparison of human chorionic gonadotropin- related components in fresh frozen serum with the proficiency testing material used by the College of American Pathologists
    George J Knight
    Foundation for Blood Research, Scarborough, ME 04074, USA
    Arch Pathol Lab Med 129:328-30. 2005
    ..The goal is to gain insight into the possible source(s) of bias attributable to the proficiency testing material (PTM) with a view toward creating more appropriate survey materials...
  58. pmc Quantitation of circulating tumor cells in blood samples from ovarian and prostate cancer patients using tumor-specific fluorescent ligands
    Wei He
    Department of Chemistry, Purdue University, West Lafayette, IN 47906, USA
    Int J Cancer 123:1968-73. 2008
    ..Use of tumor-specific fluorescent ligands to label CTCs in peripheral blood can provide a simple, accurate and sensitive method for determining the number of cancer cells circulating in the bloodstream...
  59. ncbi request reprint College of American Pathologists 2003 fresh frozen serum proficiency testing studies
    George G Klee
    Arch Pathol Lab Med 129:292-3. 2005
  60. ncbi request reprint Effects of reducing the upper limit of normal TSH values
    Vahab Fatourechi
    JAMA 290:3195-6. 2003
  61. ncbi request reprint How sensitive is a prostate-specific antigen measurement? How sensitive does it need to be?
    Jay L Bock
    Department of Pathology, Stony Brook University, Stony Brook, NY, USA
    Arch Pathol Lab Med 128:341-3. 2004
    ..These level differences (if they are also seen in clinical samples) may cause clinical problems when fixed serum PSA thresholds (eg, 0.2 ng/mL) are used to make clinical decisions related to prostate tumor recurrence...