SUNDEEP contact KHOSLA

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Relationship of sympathetic activity to bone microstructure, turnover, and plasma osteopontin levels in women
    Joshua N Farr
    College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 97:4219-27. 2012
  2. pmc Estrogen and the skeleton
    Sundeep Khosla
    Endocrine Research Unit and Kogod Center on Aging, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Trends Endocrinol Metab 23:576-81. 2012
  3. doi request reprint Benefits and risks of bisphosphonate therapy for osteoporosis
    Sundeep Khosla
    College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 97:2272-82. 2012
  4. ncbi request reprint Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: a key role for bioavailable estrogen
    S Khosla
    Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 83:2266-74. 1998
  5. pmc Osteoporosis in men
    Sundeep Khosla
    Endocrine Research Unit, Guggenheim 7, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    Endocr Rev 29:441-64. 2008
  6. ncbi request reprint Insulin-like growth factor binding protein-2: a novel regulator of skeletal gender differences?
    Sundeep Khosla
    Endocrine Research Unit, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    Endocrinology 149:2048-50. 2008
  7. ncbi request reprint Clinical practice. Osteopenia
    Sundeep Khosla
    Endocrine Research Unit, Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    N Engl J Med 356:2293-300. 2007
  8. ncbi request reprint Circulating cells with osteogenic potential
    Sundeep Khosla
    Endocrine Research Unit, Mayo Clinic, 200 First Street SW, 5 194 Joseph, Rochester, MN 55905, USA
    Ann N Y Acad Sci 1068:489-97. 2006
  9. ncbi request reprint Hormonal and biochemical determinants of trabecular microstructure at the ultradistal radius in women and men
    Sundeep Khosla
    Mayo Clinic, Endocrine Research Unit, 200 First Street SW, 5 194 Joseph, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 91:885-91. 2006
  10. pmc Effects of sex and age on bone microstructure at the ultradistal radius: a population-based noninvasive in vivo assessment
    Sundeep Khosla
    Endocrine Research Unit, Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Bone Miner Res 21:124-31. 2006

Research Grants

  1. Estrogen Regulation of the Bone Marrrow Adipocyte
    Sundeep Khosla; Fiscal Year: 2010
  2. EPIDEMIOLOGY OF AGE-RELATED BONE LOSS AND FRACTURES
    SUNDEEP contact KHOSLA; Fiscal Year: 2010
  3. Estrogen Regulation of the Bone Marrrow Adipocyte
    Sundeep Khosla; Fiscal Year: 2009
  4. Estrogen Regulation of the Bone Marrrow Adipocyte
    Sundeep Khosla; Fiscal Year: 2007
  5. Circulating Osteoblast Lineage Cells in Humans
    Sundeep Khosla; Fiscal Year: 2005
  6. EPIDEMIOLOGY OF AGE RELATED BONE LOSS AND FRACTURES
    Sundeep Khosla; Fiscal Year: 2004
  7. EPIDEMIOLOGY OF AGE-RELATED BONE LOSS AND FRACTURES
    Sundeep Khosla; Fiscal Year: 2009

Detail Information

Publications82

  1. pmc Relationship of sympathetic activity to bone microstructure, turnover, and plasma osteopontin levels in women
    Joshua N Farr
    College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 97:4219-27. 2012
    ..Studies in rodents have demonstrated that sympathetic activity reduces bone formation and bone mass; these effects are mediated by the noncollagenous matrix protein, osteopontin...
  2. pmc Estrogen and the skeleton
    Sundeep Khosla
    Endocrine Research Unit and Kogod Center on Aging, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Trends Endocrinol Metab 23:576-81. 2012
    ..Estrogen also modulates osteoblast/osteocyte and T-cell regulation of osteoclasts. Unraveling these pleiotropic effects of estrogen may lead to new approaches to prevent and treat osteoporosis...
  3. doi request reprint Benefits and risks of bisphosphonate therapy for osteoporosis
    Sundeep Khosla
    College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 97:2272-82. 2012
    ..In this perspective, we review the use of bisphosphonates for the treatment of osteoporosis, including an objective assessment of the risks vs. the benefits of these drugs...
  4. ncbi request reprint Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: a key role for bioavailable estrogen
    S Khosla
    Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 83:2266-74. 1998
    ..These studies suggest that in contrast to traditional belief, age-related bone loss may be the result of E deficiency not just in postmenopausal women, but also in men...
  5. pmc Osteoporosis in men
    Sundeep Khosla
    Endocrine Research Unit, Guggenheim 7, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    Endocr Rev 29:441-64. 2008
    ..Increasing awareness of osteoporosis in men among physicians and the lay public is critical for the prevention of fractures in our aging male population...
  6. ncbi request reprint Insulin-like growth factor binding protein-2: a novel regulator of skeletal gender differences?
    Sundeep Khosla
    Endocrine Research Unit, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    Endocrinology 149:2048-50. 2008
  7. ncbi request reprint Clinical practice. Osteopenia
    Sundeep Khosla
    Endocrine Research Unit, Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    N Engl J Med 356:2293-300. 2007
  8. ncbi request reprint Circulating cells with osteogenic potential
    Sundeep Khosla
    Endocrine Research Unit, Mayo Clinic, 200 First Street SW, 5 194 Joseph, Rochester, MN 55905, USA
    Ann N Y Acad Sci 1068:489-97. 2006
    ..The identification of these osteogenic cells in peripheral blood opens up new questions regarding the possible role of these cells in bone remodeling, in fracture repair, and possibly in vascular calcification...
  9. ncbi request reprint Hormonal and biochemical determinants of trabecular microstructure at the ultradistal radius in women and men
    Sundeep Khosla
    Mayo Clinic, Endocrine Research Unit, 200 First Street SW, 5 194 Joseph, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 91:885-91. 2006
    ....
  10. pmc Effects of sex and age on bone microstructure at the ultradistal radius: a population-based noninvasive in vivo assessment
    Sundeep Khosla
    Endocrine Research Unit, Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Bone Miner Res 21:124-31. 2006
    ..Compared with women, men had thicker trabeculae in young adulthood and had less microstructural damage with aging. These findings may contribute to the virtual immunity of men to age-related increases in wrist fractures...
  11. ncbi request reprint Relationship of estrogen receptor genotypes to bone mineral density and to rates of bone loss in men
    Sundeep Khosla
    Endocrine Research Unit, Division of Endocrinology, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 89:1808-16. 2004
    ....
  12. ncbi request reprint Role of hormonal changes in the pathogenesis of osteoporosis in men
    S Khosla
    Endocrine Research Unit, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Calcif Tissue Int 75:110-3. 2004
  13. ncbi request reprint Pathophysiology of age-related bone loss and osteoporosis
    Sundeep Khosla
    Division of Endocrinology, Metabolism, and Nutrition, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Endocrinol Metab Clin North Am 34:1015-30, xi. 2005
  14. ncbi request reprint Magic bullets to kill nasty osteoclasts
    Sundeep Khosla
    Endocrine Research Unit, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Endocrinology 146:3233-4. 2005
  15. pmc Relationship of volumetric bone density and structural parameters at different skeletal sites to sex steroid levels in women
    Sundeep Khosla
    Mayo Clinic, Endocrine Research Unit, 200 First Street SW, 5 194 Joseph, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 90:5096-103. 2005
    ..There are no data testing this in women...
  16. ncbi request reprint Estrogen, selective estrogen receptor modulators and now mechanism-specific ligands of the estrogen or androgen receptor?
    Sundeep Khosla
    Endocrine Research Unit, Division of Endocrinology, Metabolism, and Nutrition, Mayo Clinic and Foundation, 200 First Street SW, 5 194 Joseph, Rochester, MN 55905, USA
    Trends Pharmacol Sci 24:261-3. 2003
    ..These so-called mechanism-specific ligands of estrogen or androgen receptors hold considerable promise as novel approaches to treat (or at least ameliorate) the consequences of estrogen deficiency...
  17. ncbi request reprint Surrogates for fracture endpoints in clinical trials
    Sundeep Khosla
    Endocrine Research Unit, Division of Endocrinology, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Bone Miner Res 18:1146-9. 2003
  18. ncbi request reprint Relationship of serum sex steroid levels to longitudinal changes in bone density in young versus elderly men
    S Khosla
    Endocrine Research Unit, Division of Endocrinology, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 86:3555-61. 2001
    ..This subset of men is perhaps most likely to benefit from preventive therapy...
  19. ncbi request reprint Minireview: the OPG/RANKL/RANK system
    S Khosla
    Endocrine Research Unit, Division of Endocrinology, Metabolism, and Nutrition, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Endocrinology 142:5050-5. 2001
    ..e. postmenopausal osteoporosis) to the rare (i.e. familial expansile osteolysis)...
  20. ncbi request reprint Clinical review 144: Estrogen and the male skeleton
    Sundeep Khosla
    Endocrine Research Unit, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 87:1443-50. 2002
    ....
  21. ncbi request reprint Effect of estrogen versus testosterone on circulating osteoprotegerin and other cytokine levels in normal elderly men
    Sundeep Khosla
    Endocrine Research Unit, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    J Clin Endocrinol Metab 87:1550-4. 2002
    ..These differential effects of E vs. T on OPG production may explain, at least in part, why T has weaker effects than E on inhibiting bone resorption in vivo in humans...
  22. pmc Forum on aging and skeletal health: summary of the proceedings of an ASBMR workshop
    Sundeep Khosla
    College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Bone Miner Res 26:2565-78. 2011
    ..This report summarizes the major concepts presented at that meeting and in each area identifies key questions to help set the agenda for future research in skeletal aging...
  23. ncbi request reprint Relationship of volumetric BMD and structural parameters at different skeletal sites to sex steroid levels in men
    Sundeep Khosla
    Endocrine Research Unit, Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Bone Miner Res 20:730-40. 2005
    ..Associations between these bone mass/structural parameters and sex steroid levels were progressively stronger with age. Our previously postulated "threshold" for skeletal estrogen deficiency was most evident at cortical sites...
  24. ncbi request reprint Correlates of osteoprotegerin levels in women and men
    S Khosla
    Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Osteoporos Int 13:394-9. 2002
    ..Further studies directly testing these hypotheses should provide additional insights into the potential role of OPG in bone loss related to aging and sex steroid deficiency...
  25. pmc Concise review: Insights from normal bone remodeling and stem cell-based therapies for bone repair
    Sundeep Khosla
    Endocrine Research Unit, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Stem Cells 28:2124-8. 2010
    ..It is possible that they contribute directly to bone repair, but it is also likely that they express paracrine factors in the appropriate amounts and combinations that promote and sustain the healing process...
  26. pmc Comparison of sex steroid measurements in men by immunoassay versus mass spectroscopy and relationships with cortical and trabecular volumetric bone mineral density
    S Khosla
    Endocrine Research Unit, Division of Rheumatology, Department of Laboratory Medicine, and Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Osteoporos Int 19:1465-71. 2008
    ..In men, measurement of serum testosterone and estradiol levels with immunoassays correlated with mass spectroscopic measurements, and correlations of sex steroids with volumetric bone mineral density were similar...
  27. pmc The unitary model for estrogen deficiency and the pathogenesis of osteoporosis: is a revision needed?
    Sundeep Khosla
    Endocrine Research Unit, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Bone Miner Res 26:441-51. 2011
    ..In this perspective, we critically review these and other findings, leading us to conclude that our original model requires modification but not revision...
  28. pmc Update on estrogens and the skeleton
    Sundeep Khosla
    Endocrine Research Unit, Guggenheim 7, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 95:3569-77. 2010
    ..Given the diminishing clinical use of estrogen, it is logical to question whether estrogen regulation of bone remains a relevant issue at a clinical or basic research level...
  29. pmc Update in male osteoporosis
    Sundeep Khosla
    College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 95:3-10. 2010
    ..One in five men over the age of 50 yr will suffer an osteoporotic fracture during their lifetime, and men who sustain fractures have an increased mortality risk...
  30. ncbi request reprint The role of estrogens in men and androgens in women
    Sundeep Khosla
    Division of Endocrinology, Metabolism, and Nutrition, Department of Medicine, Mayo Clinic and Foundation, 200 First Street SW, 5 194 Joseph, Rochester, MN 55905, USA
    Endocrinol Metab Clin North Am 32:195-218. 2003
    ....
  31. ncbi request reprint A randomized placebo-controlled trial of short-term graded transdermal estradiol in healthy gonadotropin-releasing hormone agonist-suppressed pre- and postmenopausal women: effects on serum markers of bone turnover, insulin-like growth factor-I, and osteo
    Peter Y Liu
    Endocrine Research Unit, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 90:1953-60. 2005
    ..The effect of estradiol on bone formation does not appear to be mediated by IGF-I. In contrast, RANKL is likely to mediate the effect of estradiol on osteoclastogenesis...
  32. ncbi request reprint Effects of loss of steroid receptor coactivator-1 on the skeletal response to estrogen in mice
    Ulrike I L Modder
    Mayo Clinic, 200 First Street SW, 5 194 Joseph, Rochester, MN 55905, USA
    Endocrinology 145:913-21. 2004
    ..These findings establish that, in mice, loss of SRC-1 leads to skeletal resistance to E predominantly in cancellous bone...
  33. ncbi request reprint Estrogen receptor isoform-specific regulation of endogenous gene expression in human osteoblastic cell lines expressing either ERalpha or ERbeta
    David G Monroe
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Cell Biochem 90:315-26. 2003
    ....
  34. ncbi request reprint Mediators of the biphasic responses of bone to intermittent and continuously administered parathyroid hormone
    Rachel M Locklin
    Division of Endocrinology, Metabolism and Nutrition, Endocrine Research Unit, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    J Cell Biochem 89:180-90. 2003
    ....
  35. pmc Use of renal function measurements for assessing fracture risk in postmenopausal women
    James T McCarthy
    Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 83:1231-9. 2008
    ....
  36. pmc Skeletal effects of estrogen are mediated by opposing actions of classical and nonclassical estrogen receptor pathways
    Farhan A Syed
    Endocrine Research Unit, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Bone Miner Res 20:1992-2001. 2005
    ..This study defines the skeletal phenotype and responses to ovariectomy and estrogen replacement in these mice...
  37. ncbi request reprint Loss of ERE binding activity by estrogen receptor-alpha alters basal and estrogen-stimulated bone-related gene expression by osteoblastic cells
    Volha Rudnik
    Endocrine Research Unit, Rochester, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    J Cell Biochem 103:896-907. 2008
    ..Collectively, these findings indicate that ERE signaling plays a significant role in mediating effects of estrogen on osteoblastic differentiation markers and on IGF-I mRNA levels...
  38. ncbi request reprint Estrogen receptor isoform-specific induction of progesterone receptors in human osteoblasts
    David J Rickard
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Bone Miner Res 17:580-92. 2002
    ..Together, these results show that although estrogen can up-regulate endogenous PR gene expression in osteoblasts via both ER isoforms, ER-alpha is the predominant inducer...
  39. ncbi request reprint Two years of treatment with dehydroepiandrosterone does not improve insulin secretion, insulin action, or postprandial glucose turnover in elderly men or women
    Rita Basu
    Mayo Clinic College of Medicine, 200 1st Street SW, Rochester, MN 55905, USA
    Diabetes 56:753-66. 2007
    ..We conclude that 2 years of replacement of DHEA in elderly men and women does not improve insulin secretion, insulin action, or the pattern of postprandial glucose metabolism...
  40. ncbi request reprint Circulating osteoblast-lineage cells in humans
    Guiti Z Eghbali-Fatourechi
    Endocrine Research Unit, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    N Engl J Med 352:1959-66. 2005
    ..We further reasoned that the concentration of these cells is elevated during times of increased bone formation, such as during pubertal growth...
  41. ncbi request reprint Fracture risk in primary hyperparathyroidism
    Sundeep Khosla
    Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Bone Miner Res 17:N103-7. 2002
    ....
  42. ncbi request reprint Role of low levels of endogenous estrogen in regulation of bone resorption in late postmenopausal women
    Hassan M Heshmati
    Division of Endocrinology and Metabolism, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    J Bone Miner Res 17:172-8. 2002
    ....
  43. ncbi request reprint Changes in Runx2/Cbfa1 expression and activity during osteoblastic differentiation of human bone marrow stromal cells
    Chaoxiang Shui
    Endocrine Research Unit, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    J Bone Miner Res 18:213-21. 2003
    ..Our findings also show that the increase in Runx2/Cbfa1 activity occurs through a posttranslational mechanism involving phosphorylation of key residues...
  44. ncbi request reprint Evaluation of a prediction model for long-term fracture risk
    L Joseph Melton
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Bone Miner Res 20:551-6. 2005
    ..The NOF cost-effectiveness model, based on clinical risk factors and femoral neck aBMD, predicted overall fracture risk in a cohort of postmenopausal women followed for up to 22 years...
  45. pmc A population-based assessment of rates of bone loss at multiple skeletal sites: evidence for substantial trabecular bone loss in young adult women and men
    B Lawrence Riggs
    Endocrine Research Unit, Division of Endocrinology and Metabolism, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    J Bone Miner Res 23:205-14. 2008
    ..Cortical bone loss began in perimenopause in women and later in life in men. In contrast, trabecular bone loss began in young adulthood in both sexes...
  46. pmc Role of RANK ligand in mediating increased bone resorption in early postmenopausal women
    Guitty Eghbali-Fatourechi
    Endocrine Research Unit, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    J Clin Invest 111:1221-30. 2003
    ..The data suggest that upregulation of RANKL on bone marrow cells is an important determinant of increased bone resorption induced by estrogen deficiency...
  47. pmc Bone growth and turnover in progesterone receptor knockout mice
    David J Rickard
    Mayo Clinic, Rochester, Minnesota 55905, USA
    Endocrinology 149:2383-90. 2008
    ..However, at some skeletal sites, PR signaling attenuates the accumulation of cortical and cancellous bone mass during adolescence...
  48. ncbi request reprint Role of parathyroid hormone in mediating age-related changes in bone resorption in men
    Kurt A Kennel
    Endocrine Research Unit, Division of Endocrinology, Metabolism and Nutrition, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minn 55905, USA
    Osteoporos Int 14:631-6. 2003
    ..Since both estrogen and testosterone can attenuate the bone resorbing effects of PTH, it is possible that this difference may be due to the much milder degree of sex steroid deficiency in elderly men as compared to postmenopausal women...
  49. ncbi request reprint Fracture risk in monoclonal gammopathy of undetermined significance
    L Joseph Melton
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    J Bone Miner Res 19:25-30. 2004
    ..There was a 2.7-fold increase in the risk of axial fractures but no increase in limb fractures. The pathophysiologic basis for the increased axial fractures should be determined...
  50. ncbi request reprint Effect of 2 years of testosterone replacement on insulin secretion, insulin action, glucose effectiveness, hepatic insulin clearance, and postprandial glucose turnover in elderly men
    Rita Basu
    Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Diabetes Care 30:1972-8. 2007
    ..We sought to determine whether, and if so the mechanism by which, testosterone replacement improves carbohydrate tolerance...
  51. pmc Osteocalcin expression by circulating endothelial progenitor cells in patients with coronary atherosclerosis
    Mario Gossl
    Division of Cardiology, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 52:1314-25. 2008
    ..This study was designed to test whether patients with coronary atherosclerosis have increases in circulating endothelial progenitor cells (EPCs) expressing an osteogenic phenotype...
  52. ncbi request reprint Native osteoprotegerin gene transfer inhibits the development of murine osteolytic bone disease induced by tumor xenografts
    Patrick M Doran
    Molecular Medicine Program, Endocrine Research Unit, Mayo Clinic and Mayo Foundation, Rochester, Minn 55905, USA
    Exp Hematol 32:351-9. 2004
    ..In order to overcome these limitations, the therapeutic effects of native OPG gene transfer are examined...
  53. pmc New selective estrogen and androgen receptor modulators
    Bart L Clarke
    Mayo Clinic W18 A, Rochester, Minnesota 55905, USA
    Curr Opin Rheumatol 21:374-9. 2009
    ..Both types of compounds hold great promise for therapeutic use in multiple hormonal disorders involving tissue-specific effects mediated by estrogen or androgen receptors...
  54. pmc Skeletal consequences of deletion of steroid receptor coactivator-2/transcription intermediary factor-2
    Ulrike I Mödder
    Endocrine Research Unit, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Biol Chem 284:18767-77. 2009
    ..Modulating SRC-2 action may, thus, represent a novel therapeutic target for osteoporosis...
  55. pmc Fatty acid metabolism in the elderly: effects of dehydroepiandrosterone and testosterone replacement in hormonally deficient men and women
    Christina Koutsari
    Endocrine Research, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 94:3414-23. 2009
    ..Aging, low dehydroepiandrosterone (DHEA), and testosterone are associated with increased adiposity and metabolic risk. Treatment with these hormones may improve these abnormalities...
  56. pmc Relation of vertebral deformities to bone density, structure, and strength
    L Joseph Melton
    Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Bone Miner Res 25:1922-30. 2010
    ..Thus significantly impaired bone density, structure, and strength compared with controls indicate that many grade 1 deformities do represent early osteoporotic fractures, with corresponding implications for clinical decision making...
  57. ncbi request reprint Evidence that type I osteoporosis results from enhanced responsiveness of bone to estrogen deficiency
    B Lawrence Riggs
    Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, 200 First Street SW, MN 55905, Rochester, USA
    Osteoporos Int 14:728-33. 2003
    ..This is consistent with the hypothesis that the greater bone loss in type I osteoporosis is the result of impaired responsiveness of bone to low postmenopausal levels of sex steroids...
  58. pmc Nonoxidative free fatty acid disposal is greater in young women than men
    Christina Koutsari
    Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 96:541-7. 2011
    ....
  59. ncbi request reprint Sex steroids and the construction and conservation of the adult skeleton
    B Lawrence Riggs
    Division of Endocrinology and Metabolism, Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, Minnesota 55905, USA
    Endocr Rev 23:279-302. 2002
    ..Thus, both sex steroids are important for developing peak bone mass, but E deficiency is the major determinant of age-related bone loss in both sexes...
  60. pmc Physiology of bone loss
    Bart L Clarke
    Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic College of Medicine, 200 1st Street Southwest, Rochester, MN 55905, USA
    Radiol Clin North Am 48:483-95. 2010
    ..Further elucidation of the relative importance of each of these factors will lead to improved preventive and therapeutic approaches for osteoporosis...
  61. pmc Building bone to reverse osteoporosis and repair fractures
    Sundeep Khosla
    Endocrine Research Unit, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA
    J Clin Invest 118:421-8. 2008
    ..As we discuss here, the tremendous explosion over the last two decades in our fundamental understanding of the mechanisms of bone remodeling has led to the prospect of mechanism-based anabolic therapies for bone disorders...
  62. ncbi request reprint Role of extracellular matrix in insulin-like growth factor (IGF) binding protein-2 regulation of IGF-II action in normal human osteoblasts
    Cheryl A Conover
    Endocrine Research Unit, Division of Endocrinology, Metabolism and Nutrition, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Growth Horm IGF Res 13:328-35. 2003
    ..There was no difference between soluble and ECM-associated IGFBP-2 in affinity for IGF-I and IGF-II. These data suggest a unique mechanism for targeting an anabolic IGFBP-2/IGF-II complex in bone...
  63. ncbi request reprint Contributions of bone density and structure to fracture risk assessment in men and women
    L Joseph Melton
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Osteoporos Int 16:460-7. 2005
    ..Because of the strong correlations, however, some judgment can be used in selecting the variables easiest to measure...
  64. ncbi request reprint Population-based analysis of the relationship of whole bone strength indices and fall-related loads to age- and sex-specific patterns of hip and wrist fractures
    B Lawrence Riggs
    Endocrine Research Unit, Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Bone Miner Res 21:315-23. 2006
    ..These load/strength ratios more closely simulated patterns of wrist and hip fractures occurring in the same population than did measurement of vBMD...
  65. ncbi request reprint DHEA in elderly women and DHEA or testosterone in elderly men
    K Sreekumaran Nair
    Division of Endocrinology, Mayo Clinic, Rochester, MN 55905, USA
    N Engl J Med 355:1647-59. 2006
    ..Dehydroepiandrosterone (DHEA) and testosterone are widely promoted as antiaging supplements, but the long-term benefits, as compared with potential harm, are unknown...
  66. ncbi request reprint Effects of loss of classical estrogen response element signaling on bone in male mice
    Farhan A Syed
    Endocrine Research Unit, Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, Minnesota 55905, USA
    Endocrinology 148:1902-10. 2007
    ..Collectively, these data demonstrate that classical ERalpha signaling is crucial for the development of the murine male skeleton...
  67. ncbi request reprint Mechanisms of sex steroid effects on bone
    Farhan Syed
    Mayo Clinic College of Medicine, Rochester, MN, USA
    Biochem Biophys Res Commun 328:688-96. 2005
    ....
  68. ncbi request reprint Potential anabolic effects of androgens on bone
    Ann E Kearns
    Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Mayo Clin Proc 79:S14-8. 2004
    ..Androgens also appear to be important for bone health in pre-menopausal women. Evidence from human, animal, and laboratory studies is leading to a better understanding of the effects of androgens on bone in women...
  69. ncbi request reprint Estrogen receptor alpha and beta heterodimers exert unique effects on estrogen- and tamoxifen-dependent gene expression in human U2OS osteosarcoma cells
    David G Monroe
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, 1601C Guggenheim, 200 1st Street Southwest, Rochester, Minnesota 55905, USA
    Mol Endocrinol 19:1555-68. 2005
    ..These results suggest that the expression of both ER isoforms, forming functional ERalpha/beta heterodimers, result in unique patterns of gene regulation, many of which are distinct from the genes regulated by the ER homodimers...
  70. ncbi request reprint Skeletal stem/osteoprogenitor cells: current concepts, alternate hypotheses, and relationship to the bone remodeling compartment
    Ulrike I Mödder
    Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    J Cell Biochem 103:393-400. 2008
    ....
  71. ncbi request reprint Potential role of pancreatic and enteric hormones in regulating bone turnover
    Jackie A Clowes
    Mayo Clinic College of Medicine, Endocrine Research Unit, St Mary s Hospital, Rochester, Minnesota 55905, USA
    J Bone Miner Res 20:1497-506. 2005
  72. ncbi request reprint Population-based study of age and sex differences in bone volumetric density, size, geometry, and structure at different skeletal sites
    B Lawrence Riggs
    Endocrine Research Unit, Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Clinic College of Medicine, 200 First Street SW, 5 194 Joseph, Rochester, MN 55905, USA
    J Bone Miner Res 19:1945-54. 2004
    ..Over life, the cross-sectional area of the vertebrae and proximal femur increased by approximately 15% in both sexes, whereas vBMD at these sites decreased by 39-55% and 34-46%, respectively, with greater decreases in women than in men...
  73. ncbi request reprint Does reduced skeletal loading account for age-related bone loss?
    L Joseph Melton
    Division of Epidemiology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Bone Miner Res 21:1847-55. 2006
    ..However, in a population-based study of 375 women and 325 men (age, 21-97 years), we failed to find a close correspondence between these variables and changes in bone strength with aging...
  74. pmc Estrogen receptor beta isoform-specific induction of transforming growth factor beta-inducible early gene-1 in human osteoblast cells: an essential role for the activation function 1 domain
    John R Hawse
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Mol Endocrinol 22:1579-95. 2008
    ....
  75. ncbi request reprint A potentially deleterious role of IGFBP-2 on bone density in aging men and women
    Shreyasee Amin
    Division of Rheumatology, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Bone Miner Res 19:1075-83. 2004
    ..IGFBP-2, which increases with age in both men and women, was the strongest, most consistent predictor of BMD among the IGF/IGFBPs studied...
  76. pmc Effects of physiological variations in circulating insulin levels on bone turnover in humans
    Rita Basu
    Endocrine Research Unit, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 96:1450-5. 2011
    ..Undercarboxylated osteocalcin, in turn, enhances insulin sensitivity...
  77. ncbi request reprint Bone turnover across the menopause transition: correlations with inhibins and follicle-stimulating hormone
    Daniel S Perrien
    Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Clin Endocrinol Metab 91:1848-54. 2006
    ....
  78. ncbi request reprint The role of the immune system in the pathophysiology of osteoporosis
    Jackie A Clowes
    Mayo Clinic College of Medicine, Endocrine Research Unit, St Mary s Hospital, Rochester, MN 55905, USA
    Immunol Rev 208:207-27. 2005
    ..Although significant progress has been made, there remains much to be done in unraveling this complex interaction between the immune system and bone...
  79. ncbi request reprint Estrogen receptor isoform-specific regulation of the retinoblastoma-binding protein 1 (RBBP1) gene: roles of AF1 and enhancer elements
    David G Monroe
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Biol Chem 281:28596-604. 2006
    ..These results describe an E2-dependent, ER isoform-specific transcriptional activation of the RBBP1 gene, which in part, is explained by the differential activity of ER AF1 and enhancer element binding...
  80. ncbi request reprint High serum IGFBP-2 is predictive of increased bone turnover in aging men and women
    Shreyasee Amin
    Division of Rheumatology, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Bone Miner Res 22:799-807. 2007
    ..Studying an age-stratified community-based sample of 344 men and 276 women, IGFBP-2 was the strongest predictor of increased bone resorption among the IGF/IGFBPs studied...
  81. ncbi request reprint Effect of blockade of TNF-alpha and interleukin-1 action on bone resorption in early postmenopausal women
    Natthinee Charatcharoenwitthaya
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Bone Miner Res 22:724-9. 2007
    ..This is consistent with an important role for these immune cytokines in mediating the effect of estrogen deficiency on bone...
  82. ncbi request reprint Regulation of osteoprotegerin production by androgens and anti-androgens in human osteoblastic lineage cells
    Lorenz C Hofbauer
    Division of Endocrinology, Philipps University, Marburg, Germany
    Eur J Endocrinol 147:269-73. 2002
    ..While estrogen has been shown to induce osteoblastic OPG production, the effects of androgens on OPG production have not been defined...

Research Grants17

  1. Estrogen Regulation of the Bone Marrrow Adipocyte
    Sundeep Khosla; Fiscal Year: 2010
    ....
  2. EPIDEMIOLOGY OF AGE-RELATED BONE LOSS AND FRACTURES
    SUNDEEP contact KHOSLA; Fiscal Year: 2010
    ..A better understanding of the structural basis and risk factors for fractures should help identify the individuals who might benefit most from interventions. ..
  3. Estrogen Regulation of the Bone Marrrow Adipocyte
    Sundeep Khosla; Fiscal Year: 2009
    ....
  4. Estrogen Regulation of the Bone Marrrow Adipocyte
    Sundeep Khosla; Fiscal Year: 2007
    ....
  5. Circulating Osteoblast Lineage Cells in Humans
    Sundeep Khosla; Fiscal Year: 2005
    ..abstract_text> ..
  6. EPIDEMIOLOGY OF AGE RELATED BONE LOSS AND FRACTURES
    Sundeep Khosla; Fiscal Year: 2004
    ..The new bone structure measurements should take us to a new level of understanding of the causes of age-related bone loss and fractures and improve substantially the assessment of risk for osteoporosis. ..
  7. EPIDEMIOLOGY OF AGE-RELATED BONE LOSS AND FRACTURES
    Sundeep Khosla; Fiscal Year: 2009
    ....