S Khosla

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Insulin-like growth factor system abnormalities in hepatitis C-associated osteosclerosis. Potential insights into increasing bone mass in adults
    S Khosla
    Endocrine Research Unit, Division of Endocrinology and Metabolism, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    J Clin Invest 101:2165-73. 1998
  2. pmc Determinants of forearm strength in postmenopausal women
    L J Melton
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
    Osteoporos Int 22:3047-54. 2011
  3. ncbi request reprint Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: a key role for bioavailable estrogen
    S Khosla
    Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 83:2266-74. 1998
  4. pmc Trabecular bone deficits among Vietnamese immigrants
    L J Melton
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
    Osteoporos Int 22:1627-31. 2011
  5. pmc Estrogen action on bone marrow osteoclast lineage cells of postmenopausal women in vivo
    J A Clowes
    Division of Rheumatology and Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Osteoporos Int 20:761-9. 2009
  6. pmc Sclerostin levels during growth in children
    S Kirmani
    Endocrine Research Unit, Guggenheim 7 11, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Osteoporos Int 23:1123-30. 2012
  7. ncbi request reprint Estrogen regulation of human osteoblast function is determined by the stage of differentiation and the estrogen receptor isoform
    K M Waters
    Department of Biochemistry and Molecular Biology, Division of Endocrinology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    J Cell Biochem 83:448-62. 2001
  8. pmc Assessing forearm fracture risk in postmenopausal women
    L J Melton
    Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
    Osteoporos Int 21:1161-9. 2010
  9. ncbi request reprint Relationship of serum sex steroid levels to longitudinal changes in bone density in young versus elderly men
    S Khosla
    Endocrine Research Unit, Division of Endocrinology, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 86:3555-61. 2001
  10. pmc Relationship of femoral neck areal bone mineral density to volumetric bone mineral density, bone size, and femoral strength in men and women
    B Srinivasan
    Endocrine Research Unit, Mayo Clinic, Guggenheim 7, 200 First Street SW, Rochester, MN 55905, USA
    Osteoporos Int 23:155-62. 2012

Collaborators

Detail Information

Publications32

  1. pmc Insulin-like growth factor system abnormalities in hepatitis C-associated osteosclerosis. Potential insights into increasing bone mass in adults
    S Khosla
    Endocrine Research Unit, Division of Endocrinology and Metabolism, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    J Clin Invest 101:2165-73. 1998
    ..Our findings in HCAO suggest a possible means to increase bone mass in patients with osteoporosis...
  2. pmc Determinants of forearm strength in postmenopausal women
    L J Melton
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
    Osteoporos Int 22:3047-54. 2011
    ..The specific formula for this bone strength surrogate (-555.2 + 8.1 × [trabecular vBMD] + 19.6 × [cortical area] + 4.2 × [total cross-sectional area]) should be validated and tested in fracture risk assessment...
  3. ncbi request reprint Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: a key role for bioavailable estrogen
    S Khosla
    Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 83:2266-74. 1998
    ..These studies suggest that in contrast to traditional belief, age-related bone loss may be the result of E deficiency not just in postmenopausal women, but also in men...
  4. pmc Trabecular bone deficits among Vietnamese immigrants
    L J Melton
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
    Osteoporos Int 22:1627-31. 2011
    ....
  5. pmc Estrogen action on bone marrow osteoclast lineage cells of postmenopausal women in vivo
    J A Clowes
    Division of Rheumatology and Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Osteoporos Int 20:761-9. 2009
    ..This was not associated with changes in surface receptor for proresorptive cytokines...
  6. pmc Sclerostin levels during growth in children
    S Kirmani
    Endocrine Research Unit, Guggenheim 7 11, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Osteoporos Int 23:1123-30. 2012
    ..Serum sclerostin levels are associated with cortical porosity, suggesting that changes in sclerostin production during growth may play a role in defining cortical structure...
  7. ncbi request reprint Estrogen regulation of human osteoblast function is determined by the stage of differentiation and the estrogen receptor isoform
    K M Waters
    Department of Biochemistry and Molecular Biology, Division of Endocrinology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    J Cell Biochem 83:448-62. 2001
    ..Thus, both the ER isoform and the stage of differentiation appear to influence the response of osteoblast cells to E and TAM...
  8. pmc Assessing forearm fracture risk in postmenopausal women
    L J Melton
    Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
    Osteoporos Int 21:1161-9. 2010
    ....
  9. ncbi request reprint Relationship of serum sex steroid levels to longitudinal changes in bone density in young versus elderly men
    S Khosla
    Endocrine Research Unit, Division of Endocrinology, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 86:3555-61. 2001
    ..This subset of men is perhaps most likely to benefit from preventive therapy...
  10. pmc Relationship of femoral neck areal bone mineral density to volumetric bone mineral density, bone size, and femoral strength in men and women
    B Srinivasan
    Endocrine Research Unit, Mayo Clinic, Guggenheim 7, 200 First Street SW, Rochester, MN 55905, USA
    Osteoporos Int 23:155-62. 2012
    ....
  11. ncbi request reprint Effects of body size and skeletal site on the estimated prevalence of osteoporosis in women and men
    L J Melton
    Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Osteoporos Int 11:977-83. 2000
    ..These observations emphasize the difficulties involved in attempts to standardize BMD scores and definitions of osteoporosis for clinical use...
  12. pmc Effects of estrogen therapy on bone marrow adipocytes in postmenopausal osteoporotic women
    F A Syed
    Endocrine Research Unit and Department of Orthopedic Surgery, Mayo Clinic College of Medicine, Rochester, MN, USA
    Osteoporos Int 19:1323-30. 2008
    ..Estrogen treatment also prevented increases in mean adipocyte size over 1 year...
  13. ncbi request reprint Cytokine-specific induction of the TGF-beta inducible early gene (TIEG): regulation by specific members of the TGF-beta family
    T E Hefferan
    Department of Biochemistry and Molecular Biology, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    J Cell Biochem 78:380-90. 2000
    ....
  14. ncbi request reprint Minireview: the OPG/RANKL/RANK system
    S Khosla
    Endocrine Research Unit, Division of Endocrinology, Metabolism, and Nutrition, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Endocrinology 142:5050-5. 2001
    ..e. postmenopausal osteoporosis) to the rare (i.e. familial expansile osteolysis)...
  15. pmc Comparison of sex steroid measurements in men by immunoassay versus mass spectroscopy and relationships with cortical and trabecular volumetric bone mineral density
    S Khosla
    Endocrine Research Unit, Division of Rheumatology, Department of Laboratory Medicine, and Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Osteoporos Int 19:1465-71. 2008
    ..In men, measurement of serum testosterone and estradiol levels with immunoassays correlated with mass spectroscopic measurements, and correlations of sex steroids with volumetric bone mineral density were similar...
  16. ncbi request reprint Effects of raloxifene, a selective estrogen receptor modulator, on bone turnover markers and serum sex steroid and lipid levels in elderly men
    P M Doran
    Endocrine Research Unit, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    J Bone Miner Res 16:2118-25. 2001
    ....
  17. ncbi request reprint Regulation of osteoclastogenesis and RANK expression by TGF-beta1
    T Yan
    Endocrine Research Unit, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    J Cell Biochem 83:320-5. 2001
    ..These data thus indicate that TGF-beta directly stimulates osteoclastic differentiation, and this is accompanied by increased RANK mRNA and protein expression...
  18. ncbi request reprint Role of serum leptin, insulin, and estrogen levels as potential mediators of the relationship between fat mass and bone mineral density in men versus women
    T Thomas
    Endocrine Research Unit, Division of Endocrinology, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Bone 29:114-20. 2001
    ..In women, leptin may also mediate at least part of the protective effect of fat mass on the skeleton...
  19. ncbi request reprint Estrogens and bone health in men
    S Khosla
    Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Calcif Tissue Int 69:189-92. 2001
    ..Collectively then, these findings indicate that estrogen plays a dominant role in regulating the male skeleton...
  20. pmc The skeletal response to estrogen is impaired in female but not in male steroid receptor coactivator (SRC)-1 knock out mice
    U I Modder
    Endocrine Research Unit, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Bone 42:414-21. 2008
    ....
  21. ncbi request reprint Bone marrow stromal cells express two distinct splice variants of ER-alpha that are regulated by estrogen
    A Sanyal
    Endocrine Research Unit, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Cell Biochem 94:88-97. 2005
    ..These data thus indicate that: (1) bone marrow stromal cells express at least two variants of ER-alpha and (2) estrogen down regulates the ER-alpha mRNA and protein in these cells...
  22. ncbi request reprint A fragment of the hypophosphatemic factor, MEPE, requires inducible cyclooxygenase-2 to exert potent anabolic effects on normal human marrow osteoblast precursors
    D E Nagel
    Endocrine Research Unit, Division of Endocrinology, Metabolism and Nutrition, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Cell Biochem 93:1107-14. 2004
    ..Thus, AC-100 has potent anabolic activity on osteoblast precursor cells in vitro and these effects require the induction of COX-2...
  23. ncbi request reprint Prospective randomized study of effects of unopposed estrogen replacement therapy on markers of coagulation and inflammation in postmenopausal women
    M D Luyer
    Department of Surgery, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 86:3629-34. 2001
    ..Concomitant changes in these parameters may reduce the risk for arterial disease while altering the threshold for thrombotic events...
  24. ncbi request reprint Role of hormonal changes in the pathogenesis of osteoporosis in men
    S Khosla
    Endocrine Research Unit, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Calcif Tissue Int 75:110-3. 2004
  25. ncbi request reprint Correlates of osteoprotegerin levels in women and men
    S Khosla
    Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Osteoporos Int 13:394-9. 2002
    ..Further studies directly testing these hypotheses should provide additional insights into the potential role of OPG in bone loss related to aging and sex steroid deficiency...
  26. ncbi request reprint Mutual antagonism of estrogen receptors alpha and beta and their preferred interactions with steroid receptor coactivators in human osteoblastic cell lines
    D G Monroe
    Department of Molecular Biology and Biochemistry, Mayo Clinic and Mayo Foundation, 200 1st Avenue SW, Rochester, Minnesota 55905, USA
    J Endocrinol 176:349-57. 2003
    ..These data suggest that the transactivation capacity of various ER isoforms is both SRC species and cell type dependent...
  27. ncbi request reprint Phytoestrogen genistein acts as an estrogen agonist on human osteoblastic cells through estrogen receptors alpha and beta
    D J Rickard
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Cell Biochem 89:633-46. 2003
    ..Together, these findings demonstrate that genistein behaves as a weak E(2) agonist in osteoblasts and can utilize both ERalpha and ERbeta...
  28. ncbi request reprint Osteoporosis in men--consensus is premature
    E Seeman
    Austin Hospital, Heidelberg, 3084, Melbourne, Victoria, Australia
    Calcif Tissue Int 75:120-2. 2004
  29. pmc Cost-effective osteoporosis treatment thresholds: the United States perspective
    A N A Tosteson
    Multidisciplinary Clinical Research Center in Musculoskeletal Diseases and The Dartmouth Institute for Health Policy and Clinical Practice, Dartmouth Medical School, Lebanon, NH 03756, USA
    Osteoporos Int 19:437-47. 2008
    ..A 3% 10-year risk of hip fracture was generally required for osteoporosis treatment to cost less than $60,000 per QALY gained...
  30. ncbi request reprint Secondary osteoporosis and the risk of distal forearm fractures in men and women
    L J Melton
    Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Bone 31:119-25. 2002
    ..These factors do not appear to account for the discrepancy in forearm fracture incidence in women when compared with men...
  31. doi request reprint Implications of absolute fracture risk assessment for osteoporosis practice guidelines in the USA
    B Dawson-Hughes
    Bone Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Osteoporos Int 19:449-58. 2008
    ....
  32. ncbi request reprint Bone fragility in men--where are we?
    E Seeman
    Austin Health, Centaur Building, Repatriation Campus, Heidelberg, 3082, Melbourne, Australia
    Osteoporos Int 17:1577-83. 2006
    ..Advances in the study of bone fragility in men have taken place, but many challenges remain...