David KatzmannSummaryAffiliation: Mayo Clinic Country: USA Publications
Research Grants
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Detail Information
Publications
Multilevel Parallelization of AutoDock 4.2Andrew P Norgan
IBM, Rochester, MN, USA
J Cheminform 3:12. 2011..abstract:..
Receptor downregulation and multivesicular-body sortingDavid J Katzmann
Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA
Nat Rev Mol Cell Biol 3:893-905. 2002....- Mvb12 is a novel member of ESCRT-I involved in cargo selection by the multivesicular body pathwayAndrea J Oestreich
Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Mol Biol Cell 18:646-57. 2007..These data support a model in which Mvb12 impacts the selection of MVB cargoes by modulating the cargo recognition capabilities of ESCRT-I... - No ESCRT to the melanosome: MVB sorting without ubiquitinDavid J Katzmann
Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, 1607 Guggenheim, Rochester, Minnesota 55905, USA
Dev Cell 10:278-80. 2006..To date, delivery into MVBs has been dependent on the ESCRT machinery. However, analysis of a melanosomal protein has uncovered an alternative pathway for MVB sorting... 
Recycling of ESCRTs by the AAA-ATPase Vps4 is regulated by a conserved VSL region in Vta1Ishara Azmi
Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
J Cell Biol 172:705-17. 2006..These results suggest an evolutionarily conserved mechanism through which the disassembly of the ESCRT proteins, and thereby MVB sorting, is regulated by the Vta1/SBP1/LIP5 proteins...- Vps9p CUE domain ubiquitin binding is required for efficient endocytic protein trafficBrian A Davies
Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA
J Biol Chem 278:19826-33. 2003..These findings define a new ubiquitin binding domain and implicate ubiquitin as a modulator of Vps9p function in the endocytic pathway... - Characterization of multiple multivesicular body sorting determinants within Sna3: a role for the ubiquitin ligase Rsp5Andrea J Oestreich
Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Mol Biol Cell 18:707-20. 2007..These data indicate that Rsp5 function is required for MVB targeting of Sna3 in a capacity beyond cargo ubiquitination. These results uncover a series of determinants impacting Sna3 MVB sorting, including unexpected roles for Rsp5... - The HECT domain of the ubiquitin ligase Rsp5 contributes to substrate recognitionJacqueline R E Lee
Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
J Biol Chem 284:32126-37. 2009..These results highlight the ability of Rsp5 to interact with substrates via multiple modalities, suggesting additional mechanisms of regulating this interaction and relevant outcomes... 
Regulation of Vps4 ATPase activity by ESCRT-IIIBrian A Davies
Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, 200 First Street S W, Rochester, MN 55905, USA
Biochem Soc Trans 37:143-5. 2009..These studies support a model wherein Vps4 activity is subject to spatial and temporal regulation via distinct mechanisms during MVB sorting...- Analysis of ubiquitin-dependent protein sorting within the endocytic pathway in Saccharomyces cerevisiaeDavid J Katzmann
Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
Methods Enzymol 399:192-211. 2005..Here we provide detailed protocols for studying the fate of cargo proteins within the endosomal system, as well as the role of putative ubiquitin-binding proteins... - ESCRT-III family members stimulate Vps4 ATPase activity directly or via Vta1Ishara F Azmi
Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Dev Cell 14:50-61. 2008..These data support a model wherein a network of MIT and MIT-like domain interactions with ESCRT-III subunits contributes to the regulation of Vps4 activity during MVB sorting... - Biogenesis and function of multivesicular bodiesRobert C Piper
Department of Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, USA
Annu Rev Cell Dev Biol 23:519-47. 2007..However, major questions remain as to exactly what these proteins do at the molecular level and how they may accomplish these tasks... - Bro1 is an endosome-associated protein that functions in the MVB pathway in Saccharomyces cerevisiaeGreg Odorizzi
Department of Molecular, Cellular and Developmental Biology, University of Colorado, Campus Box 347, Boulder, CO 80309, USA
J Cell Sci 116:1893-903. 2003..Our data suggest that the function of Bro1 in the MVB pathway takes place on endosomal membranes and occurs in concert with or downstream of the function of the ESCRT-III complex... - Escrt-III: an endosome-associated heterooligomeric protein complex required for mvb sortingMarkus Babst
Department of Cellular and Molecular Medicine and Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla 92093, USA
Dev Cell 3:271-82. 2002..The Vps2-Vps24 subcomplex binds to the Vps20-Snf7 complex and thereby serves to recruit additional cofactors to this site of protein sorting. We provide evidence for a role for ESCRT-III in sorting and/or concentration of MVB cargoes... - Endosome-associated complex, ESCRT-II, recruits transport machinery for protein sorting at the multivesicular bodyMarkus Babst
Department of Cellular and Molecular Medicine and Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla 92093, USA
Dev Cell 3:283-9. 2002..We propose that the ESCRT complexes perform a coordinated cascade of events to select and sort MVB cargoes for delivery to the lumen of the vacuole/lysosome... - Multivesicular body sorting: ubiquitin ligase Rsp5 is required for the modification and sorting of carboxypeptidase SDavid J Katzmann
Department of Cellular and Molecular Medicine, Howard Hughes Medical Institute, University of California, San Diego, School of Medicine, La Jolla, California 92093 0668, USA
Mol Biol Cell 15:468-80. 2004..Thus, both Rsp5 and Fab1 play distinct and essential roles in the targeting of biosynthetic MVB cargoes. However, whereas Rsp5 seems to be responsible for cargo ubiquitination, the precise role for Fab1 remains to be elucidated... - Vps27 recruits ESCRT machinery to endosomes during MVB sortingDavid J Katzmann
Department of Cellular and Molecular Medicine, and Howard Hughes Medical Institute, University of California, San Diego School of Medicine, La Jolla, CA 92093-0688, USA
J Cell Biol 162:413-23. 2003..Vps27 subsequently recruits/activates ESCRT-I on endosomes, thereby facilitating sorting of ubiquitinated MVB cargoes... - Epsins and Vps27p/Hrs contain ubiquitin-binding domains that function in receptor endocytosisSusan C Shih
Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL, 60208 3500, USA
Nat Cell Biol 4:389-93. 2002..UIM domains are found in a broad spectrum of proteins, consistent with the idea that mono-ubiquitin can function as a regulatory signal to control diverse biological activities... - Structural basis of Vta1 function in the multivesicular body sorting pathwayJunyu Xiao
Life Sciences Institute and Department of Biological Chemistry, Medical School, University of Michigan, Ann Arbor, MI 48109, USA
Dev Cell 14:37-49. 2008..This provides an additional level of regulation and coordination for ESCRT-III assembly and disassembly...
Research Grants
- Mechanisms of Endosomal SortingDavid Katzmann; Fiscal Year: 2007....
- Mechanisms of Endosomal SortingDavid Katzmann; Fiscal Year: 2009....
- Mechanisms of Endosomal SortingDavid J Katzmann; Fiscal Year: 2010..Understanding how this process takes place will lead to insights into the prevention of cancer, neurodegenerative diseases and hypertension as well as mechanisms of viral reproduction. ..