David Katzmann

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc ESCRT-independent budding of HIV-1 gag virus-like particles from Saccharomyces cerevisiae spheroplasts
    Andrew P Norgan
    Department of Biochemistry and Molecular Biology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    PLoS ONE 7:e52603. 2012
  2. pmc Coordination of substrate binding and ATP hydrolysis in Vps4-mediated ESCRT-III disassembly
    Brian A Davies
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Mol Biol Cell 21:3396-408. 2010
  3. pmc ESCRT ubiquitin-binding domains function cooperatively during MVB cargo sorting
    S Brookhart Shields
    Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA 52240, USA
    J Cell Biol 185:213-24. 2009
  4. pmc Multilevel Parallelization of AutoDock 4.2
    Andrew P Norgan
    IBM, Rochester, MN, USA
    J Cheminform 3:12. 2011
  5. ncbi request reprint Receptor downregulation and multivesicular-body sorting
    David J Katzmann
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Nat Rev Mol Cell Biol 3:893-905. 2002
  6. pmc Mvb12 is a novel member of ESCRT-I involved in cargo selection by the multivesicular body pathway
    Andrea J Oestreich
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Mol Biol Cell 18:646-57. 2007
  7. ncbi request reprint No ESCRT to the melanosome: MVB sorting without ubiquitin
    David J Katzmann
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, 1607 Guggenheim, Rochester, Minnesota 55905, USA
    Dev Cell 10:278-80. 2006
  8. pmc Recycling of ESCRTs by the AAA-ATPase Vps4 is regulated by a conserved VSL region in Vta1
    Ishara Azmi
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Cell Biol 172:705-17. 2006
  9. ncbi request reprint Vps9p CUE domain ubiquitin binding is required for efficient endocytic protein traffic
    Brian A Davies
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Biol Chem 278:19826-33. 2003
  10. pmc The HECT domain of the ubiquitin ligase Rsp5 contributes to substrate recognition
    Jacqueline R E Lee
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Biol Chem 284:32126-37. 2009

Research Grants

  1. Mechanisms of Endosomal Sorting
    David Katzmann; Fiscal Year: 2006
  2. Mechanisms of Endosomal Sorting
    David Katzmann; Fiscal Year: 2007
  3. Mechanisms of Endosomal Sorting
    David Katzmann; Fiscal Year: 2009
  4. Mechanisms of Endosomal Sorting
    David J Katzmann; Fiscal Year: 2010

Collaborators

  • Markus Babst
  • Zhiguo Zhang
  • Scott D Emr
  • Greg Odorizzi
  • Zhaohui Xu
  • Zhijian Chen
  • BEVERLY R WENDLAND
  • Robert C Piper
  • LINDA A HICKE
  • Anjon Audhya
  • Brian A Davies
  • Andrea J Oestreich
  • Andrew P Norgan
  • Ishara F Azmi
  • Johanna A Payne
  • Jacqueline R E Lee
  • Junyu Xiao
  • Johanna Payne
  • Ishara Azmi
  • S Brookhart Shields
  • Bruce F Horazdovsky
  • Shengbing Huang
  • Susan C Shih
  • Eugene W Krueger
  • Jean Pierre A Kocher
  • Carlos P Sosa
  • Paul K Coffman
  • Anna Shestakova
  • Mia S Gunawan
  • Stanley Winistorfer
  • Doris Nguyen
  • Hengchuan Xia
  • Jiahai Zhou
  • Mariam Aboian
  • Jacqueline Lee
  • Rachel Issaka
  • Christian Dimaano
  • Brian Davies
  • Debra Eckert
  • Hui Zhou
  • Mark Hochstrasser
  • Elena Atanasova
  • Gregory G Tall
  • Andrew S Friedberg
  • Li Deng
  • Agnel J Sfeir
  • Darren S Carney
  • Justin D Topp
  • Joshua D Schnell
  • Myra Sutanto

Detail Information

Publications23

  1. pmc ESCRT-independent budding of HIV-1 gag virus-like particles from Saccharomyces cerevisiae spheroplasts
    Andrew P Norgan
    Department of Biochemistry and Molecular Biology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    PLoS ONE 7:e52603. 2012
    ..Thus the myriad of genetic and biochemical tools available in the yeast system may be of utility in the study of this aspect of viral budding...
  2. pmc Coordination of substrate binding and ATP hydrolysis in Vps4-mediated ESCRT-III disassembly
    Brian A Davies
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Mol Biol Cell 21:3396-408. 2010
    ..These results suggest that Vps4 functions as a stable oligomer that acts upon individual ESCRT-III subunits to facilitate ESCRT-III disassembly...
  3. pmc ESCRT ubiquitin-binding domains function cooperatively during MVB cargo sorting
    S Brookhart Shields
    Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA 52240, USA
    J Cell Biol 185:213-24. 2009
    ..These experiments reveal an unexpected level of coordination among the ESCRT UBDs, suggesting that they collectively recognize a diverse set of cargo rather than act sequentially at discrete steps...
  4. pmc Multilevel Parallelization of AutoDock 4.2
    Andrew P Norgan
    IBM, Rochester, MN, USA
    J Cheminform 3:12. 2011
    ..abstract:..
  5. ncbi request reprint Receptor downregulation and multivesicular-body sorting
    David J Katzmann
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Nat Rev Mol Cell Biol 3:893-905. 2002
    ....
  6. pmc Mvb12 is a novel member of ESCRT-I involved in cargo selection by the multivesicular body pathway
    Andrea J Oestreich
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Mol Biol Cell 18:646-57. 2007
    ..These data support a model in which Mvb12 impacts the selection of MVB cargoes by modulating the cargo recognition capabilities of ESCRT-I...
  7. ncbi request reprint No ESCRT to the melanosome: MVB sorting without ubiquitin
    David J Katzmann
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, 1607 Guggenheim, Rochester, Minnesota 55905, USA
    Dev Cell 10:278-80. 2006
    ..To date, delivery into MVBs has been dependent on the ESCRT machinery. However, analysis of a melanosomal protein has uncovered an alternative pathway for MVB sorting...
  8. pmc Recycling of ESCRTs by the AAA-ATPase Vps4 is regulated by a conserved VSL region in Vta1
    Ishara Azmi
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Cell Biol 172:705-17. 2006
    ..These results suggest an evolutionarily conserved mechanism through which the disassembly of the ESCRT proteins, and thereby MVB sorting, is regulated by the Vta1/SBP1/LIP5 proteins...
  9. ncbi request reprint Vps9p CUE domain ubiquitin binding is required for efficient endocytic protein traffic
    Brian A Davies
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Biol Chem 278:19826-33. 2003
    ..These findings define a new ubiquitin binding domain and implicate ubiquitin as a modulator of Vps9p function in the endocytic pathway...
  10. pmc The HECT domain of the ubiquitin ligase Rsp5 contributes to substrate recognition
    Jacqueline R E Lee
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Biol Chem 284:32126-37. 2009
    ..These results highlight the ability of Rsp5 to interact with substrates via multiple modalities, suggesting additional mechanisms of regulating this interaction and relevant outcomes...
  11. pmc Characterization of multiple multivesicular body sorting determinants within Sna3: a role for the ubiquitin ligase Rsp5
    Andrea J Oestreich
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Mol Biol Cell 18:707-20. 2007
    ..These data indicate that Rsp5 function is required for MVB targeting of Sna3 in a capacity beyond cargo ubiquitination. These results uncover a series of determinants impacting Sna3 MVB sorting, including unexpected roles for Rsp5...
  12. pmc Rtt106p is a histone chaperone involved in heterochromatin-mediated silencing
    Shengbing Huang
    Department of Biochemistry and Molecular Biology, Mayo Clinic, College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Proc Natl Acad Sci U S A 102:13410-5. 2005
    ..Furthermore, Rtt106p interacts with CAF-1 physically through Cac1p. These biochemical and genetic data indicate that Rtt106p is a previously uncharacterized histone chaperone connecting S phase to epigenetic inheritance...
  13. ncbi request reprint Analysis of ubiquitin-dependent protein sorting within the endocytic pathway in Saccharomyces cerevisiae
    David J Katzmann
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Methods Enzymol 399:192-211. 2005
    ..Here we provide detailed protocols for studying the fate of cargo proteins within the endosomal system, as well as the role of putative ubiquitin-binding proteins...
  14. pmc Regulation of Vps4 ATPase activity by ESCRT-III
    Brian A Davies
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, 200 First Street S W, Rochester, MN 55905, USA
    Biochem Soc Trans 37:143-5. 2009
    ..These studies support a model wherein Vps4 activity is subject to spatial and temporal regulation via distinct mechanisms during MVB sorting...
  15. doi request reprint ESCRT-III family members stimulate Vps4 ATPase activity directly or via Vta1
    Ishara F Azmi
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Dev Cell 14:50-61. 2008
    ..These data support a model wherein a network of MIT and MIT-like domain interactions with ESCRT-III subunits contributes to the regulation of Vps4 activity during MVB sorting...
  16. ncbi request reprint Escrt-III: an endosome-associated heterooligomeric protein complex required for mvb sorting
    Markus Babst
    Department of Cellular and Molecular Medicine and Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla 92093, USA
    Dev Cell 3:271-82. 2002
    ..The Vps2-Vps24 subcomplex binds to the Vps20-Snf7 complex and thereby serves to recruit additional cofactors to this site of protein sorting. We provide evidence for a role for ESCRT-III in sorting and/or concentration of MVB cargoes...
  17. ncbi request reprint Endosome-associated complex, ESCRT-II, recruits transport machinery for protein sorting at the multivesicular body
    Markus Babst
    Department of Cellular and Molecular Medicine and Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla 92093, USA
    Dev Cell 3:283-9. 2002
    ..We propose that the ESCRT complexes perform a coordinated cascade of events to select and sort MVB cargoes for delivery to the lumen of the vacuole/lysosome...
  18. ncbi request reprint Epsins and Vps27p/Hrs contain ubiquitin-binding domains that function in receptor endocytosis
    Susan C Shih
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL, 60208 3500, USA
    Nat Cell Biol 4:389-93. 2002
    ..UIM domains are found in a broad spectrum of proteins, consistent with the idea that mono-ubiquitin can function as a regulatory signal to control diverse biological activities...
  19. pmc Biogenesis and function of multivesicular bodies
    Robert C Piper
    Department of Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, USA
    Annu Rev Cell Dev Biol 23:519-47. 2007
    ..However, major questions remain as to exactly what these proteins do at the molecular level and how they may accomplish these tasks...
  20. ncbi request reprint Bro1 is an endosome-associated protein that functions in the MVB pathway in Saccharomyces cerevisiae
    Greg Odorizzi
    Department of Molecular, Cellular and Developmental Biology, University of Colorado, Campus Box 347, Boulder, CO 80309, USA
    J Cell Sci 116:1893-903. 2003
    ..Our data suggest that the function of Bro1 in the MVB pathway takes place on endosomal membranes and occurs in concert with or downstream of the function of the ESCRT-III complex...
  21. pmc Vps27 recruits ESCRT machinery to endosomes during MVB sorting
    David J Katzmann
    Department of Cellular and Molecular Medicine, and Howard Hughes Medical Institute, University of California, San Diego School of Medicine, La Jolla, CA 92093 0688, USA
    J Cell Biol 162:413-23. 2003
    ..Vps27 subsequently recruits/activates ESCRT-I on endosomes, thereby facilitating sorting of ubiquitinated MVB cargoes...
  22. pmc Multivesicular body sorting: ubiquitin ligase Rsp5 is required for the modification and sorting of carboxypeptidase S
    David J Katzmann
    Department of Cellular and Molecular Medicine, Howard Hughes Medical Institute, University of California, San Diego, School of Medicine, La Jolla, California 92093 0668, USA
    Mol Biol Cell 15:468-80. 2004
    ..Thus, both Rsp5 and Fab1 play distinct and essential roles in the targeting of biosynthetic MVB cargoes. However, whereas Rsp5 seems to be responsible for cargo ubiquitination, the precise role for Fab1 remains to be elucidated...
  23. pmc Structural basis of Vta1 function in the multivesicular body sorting pathway
    Junyu Xiao
    Life Sciences Institute and Department of Biological Chemistry, Medical School, University of Michigan, Ann Arbor, MI 48109, USA
    Dev Cell 14:37-49. 2008
    ..This provides an additional level of regulation and coordination for ESCRT-III assembly and disassembly...

Research Grants5

  1. Mechanisms of Endosomal Sorting
    David Katzmann; Fiscal Year: 2006
    ....
  2. Mechanisms of Endosomal Sorting
    David Katzmann; Fiscal Year: 2007
    ....
  3. Mechanisms of Endosomal Sorting
    David Katzmann; Fiscal Year: 2009
    ....
  4. Mechanisms of Endosomal Sorting
    David J Katzmann; Fiscal Year: 2010
    ..Understanding how this process takes place will lead to insights into the prevention of cancer, neurodegenerative diseases and hypertension as well as mechanisms of viral reproduction. ..