K Kantarci


Affiliation: Mayo Clinic
Country: USA


  1. Nedelska Z, Senjem M, Przybelski S, Lesnick T, Lowe V, Boeve B, et al. Regional cortical perfusion on arterial spin labeling MRI in dementia with Lewy bodies: Associations with clinical severity, glucose metabolism and tau PET. Neuroimage Clin. 2018;19:939-947 pubmed publisher
    ..Non-invasive and radiotracer-free ASL-MRI may be further developed as a tool for the screening and diagnostic evaluation of DLB patients in a variety of clinical settings where FDG-PET is not accessible. ..
  2. Kantarci K, Knopman D, Dickson D, Parisi J, Whitwell J, Weigand S, et al. Alzheimer disease: postmortem neuropathologic correlates of antemortem 1H MR spectroscopy metabolite measurements. Radiology. 2008;248:210-20 pubmed publisher
  3. Murray M, Przybelski S, Lesnick T, Liesinger A, Spychalla A, Zhang B, et al. Early Alzheimer's disease neuropathology detected by proton MR spectroscopy. J Neurosci. 2014;34:16247-55 pubmed publisher
    ..In addition, elevation of mI/Cr is associated with the occurrence of amyloid-β plaques in AD. ..
  4. Kantarci K. Proton MRS in mild cognitive impairment. J Magn Reson Imaging. 2013;37:770-7 pubmed publisher
    ..The role of proton MRS will be critical for pathophysiological processes for which a reliable biomarker does not exist such as neuronal dysfunction, glial and microglial activation in MCI. ..
  5. Nedelska Z, Schwarz C, Boeve B, Lowe V, Reid R, Przybelski S, et al. White matter integrity in dementia with Lewy bodies: a voxel-based analysis of diffusion tensor imaging. Neurobiol Aging. 2015;36:2010-7 pubmed publisher
    ..Cortical glucose hypometabolism accompanies WM FA alterations with a concordant pattern of gray and WM involvement in the parietooccipital lobes in DLB. ..
  6. Kantarci K. 1H magnetic resonance spectroscopy in dementia. Br J Radiol. 2007;80 Spec No 2:S146-52 pubmed publisher
    ..Overall, MRS is a promising investigational technique in ageing and dementia at this time. The potential clinical application of MRS in ageing and dementia, however, is growing with technical advances in the field. ..
  7. Kantarci K, Tosakulwong N, Lesnick T, Zuk S, Lowe V, Fields J, et al. Brain structure and cognition 3 years after the end of an early menopausal hormone therapy trial. Neurology. 2018;90:e1404-e1412 pubmed publisher
  8. Gungor I, Sarro L, Graff Radford J, Zuk S, Tosakulwong N, Przybelski S, et al. Frequency and topography of cerebral microbleeds in dementia with Lewy bodies compared to Alzheimer's disease. Parkinsonism Relat Disord. 2015;21:1101-4 pubmed publisher
    ..05). CMBs are as common in patients with DLB as in patients with AD, with highest densities observed in the occipital lobes, suggesting common pathophysiologic mechanisms underlying CMBs in both diseases. ..
  9. Kantarci K. Magnetic resonance spectroscopy in common dementias. Neuroimaging Clin N Am. 2013;23:393-406 pubmed publisher

More Information


  1. Barnes J, Harvey R, Zuk S, Lundt E, Lesnick T, Gunter J, et al. Aortic hemodynamics and white matter hyperintensities in normotensive postmenopausal women. J Neurol. 2017;264:938-945 pubmed publisher
    ..Our results suggest that assessing aortic hemodynamics may identify individuals at risk for accelerated development of WMH and guide early treatment to reduce WMH burden and cognitive impairment in the future. ..
  2. Kantarci K, Weigand S, Przybelski S, Shiung M, Whitwell J, Negash S, et al. Risk of dementia in MCI: combined effect of cerebrovascular disease, volumetric MRI, and 1H MRS. Neurology. 2009;72:1519-25 pubmed publisher
  3. Sarro L, Senjem M, Lundt E, Przybelski S, Lesnick T, Graff Radford J, et al. Amyloid-β deposition and regional grey matter atrophy rates in dementia with Lewy bodies. Brain. 2016;139:2740-2750 pubmed
    ..Furthermore, higher amyloid-β deposition at baseline predicts a faster clinical decline over time in patients with probable dementia with Lewy bodies. ..
  4. Sarro L, Tosakulwong N, Schwarz C, Graff Radford J, Przybelski S, Lesnick T, et al. An investigation of cerebrovascular lesions in dementia with Lewy bodies compared to Alzheimer's disease. Alzheimers Dement. 2017;13:257-266 pubmed publisher
    ..Frequency of infarcts in DLB was not different from CN and AD dementia. In DLB, WMH volume is higher than AD and CN and appears to be primarily associated with history of vascular disease. ..
  5. Kantarci K, Lesnick T, Ferman T, Przybelski S, Boeve B, Smith G, et al. Hippocampal volumes predict risk of dementia with Lewy bodies in mild cognitive impairment. Neurology. 2016;87:2317-2323 pubmed
    ..Preservation of HV may support prodromal DLB over AD, particularly in patients with MCI with nonamnestic features. ..
  6. Graff Radford J, Murray M, Lowe V, Boeve B, Ferman T, Przybelski S, et al. Dementia with Lewy bodies: basis of cingulate island sign. Neurology. 2014;83:801-9 pubmed publisher
    ..Identifying biomarkers that measure relative contributions of underlying pathologies to dementia is critical as neurotherapeutics move toward targeted treatments. ..
  7. Kantarci K, Tosakulwong N, Lesnick T, Zuk S, Gunter J, Gleason C, et al. Effects of hormone therapy on brain structure: A randomized controlled trial. Neurology. 2016;87:887-96 pubmed publisher
    ..This study provides Class I evidence that brain ventricular volume increased to a greater extent in recently menopausal women who received oral CEE compared to placebo. ..
  8. Kantarci K, Ferman T, Boeve B, Weigand S, Przybelski S, Vemuri P, et al. Focal atrophy on MRI and neuropathologic classification of dementia with Lewy bodies. Neurology. 2012;79:553-60 pubmed publisher
    ..To determine the association between the focal atrophy measures on antemortem MRI and postmortem neuropathologic classification of dementia with Lewy bodies (DLB) using the Third Report of the DLB Consortium criteria...
  9. Nedelska Z, Przybelski S, Lesnick T, Schwarz C, Lowe V, Machulda M, et al. 1H-MRS metabolites and rate of ?-amyloid accumulation on serial PET in clinically normal adults. Neurology. 2017;89:1391-1399 pubmed publisher
  10. Kantarci K, Lowe V, Boeve B, Weigand S, Senjem M, Przybelski S, et al. Multimodality imaging characteristics of dementia with Lewy bodies. Neurobiol Aging. 2012;33:2091-105 pubmed publisher
    ..Occipital and posterior parietotemporal lobe hypometabolism is a distinguishing feature of DLB and this regional hypometabolic pattern is independent of the amyloid pathology...
  11. Kantarci K, Lowe V, Przybelski S, Weigand S, Senjem M, Ivnik R, et al. APOE modifies the association between A? load and cognition in cognitively normal older adults. Neurology. 2012;78:232-40 pubmed publisher
  12. Kantarci K, Lowe V, Przybelski S, Senjem M, Weigand S, Ivnik R, et al. Magnetic resonance spectroscopy, ?-amyloid load, and cognition in a population-based sample of cognitively normal older adults. Neurology. 2011;77:951-8 pubmed publisher
  13. Kantarci K, Murray M, Schwarz C, Reid R, Przybelski S, Lesnick T, et al. White-matter integrity on DTI and the pathologic staging of Alzheimer's disease. Neurobiol Aging. 2017;56:172-179 pubmed publisher
    ..The NFT pathology of AD is associated with DTI alterations involving the medial temporal limbic connections and medial parietal white matter. This pattern of diffusion abnormalities is also associated with clinical disease severity. ..
  14. Kantarci K, Yang C, Schneider J, Senjem M, Reyes D, Lowe V, et al. Antemortem amyloid imaging and ?-amyloid pathology in a case with dementia with Lewy bodies. Neurobiol Aging. 2012;33:878-85 pubmed publisher
    ..36; p = 0.17). The ROI-based analysis of imaging and histopathological data confirms that PiB uptake on PET is a specific marker for A? density, but cannot differentiate neuritic from diffuse amyloid plaques in this case with DLB. ..