Michael Joyner


Affiliation: Mayo Clinic
Country: USA


  1. Joyner M, Limberg J. Insulin and sympathoexcitation: it is not all in your head. Diabetes. 2013;62:2654-5 pubmed publisher
  2. Limberg J, Taylor J, Mozer M, Dube S, Basu A, Basu R, et al. Effect of bilateral carotid body resection on cardiac baroreflex control of blood pressure during hypoglycemia. Hypertension. 2015;65:1365-71 pubmed publisher
    ..These data support a contribution of the carotid chemoreceptors to blood pressure control and highlight the potential widespread effects of carotid body resection in humans. ..
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    Joyner M. Baroreceptor function during exercise: resetting the record. Exp Physiol. 2006;91:27-36 pubmed
    ..Additionally, the key contributions of John Shepherd and the late David Donald (along with their colleagues) on related issues are noted. ..
  4. Joyner M. Has Neo-Darwinism failed clinical medicine: does systems biology have to?. Prog Biophys Mol Biol. 2015;117:107-12 pubmed publisher
    ..one solely related to dysfunctional cardiomyocytes. I close by arguing that a physiological perspective is essential to reconcile reductionism with what is required to understand and treat disease. ..
  5. Limberg J, Johnson B, Holbein W, Ranadive S, Mozer M, Joyner M. Interindividual variability in the dose-specific effect of dopamine on carotid chemoreceptor sensitivity to hypoxia. J Appl Physiol (1985). 2016;120:138-47 pubmed publisher
    ..In conclusion, we did not find a single dose of dopamine that elicited a nadir HVR in all subjects. Additionally, potential confounding cardiovascular responses occur with dopamine infusion, which may limit its usage. ..
  6. Joyner M, Limberg J. Blood Pressure: Return of the Sympathetics?. Curr Hypertens Rep. 2016;18:7 pubmed publisher
  7. Joyner M. Giant sucking sound: can physiology fill the intellectual void left by the reductionists?. J Appl Physiol (1985). 2011;111:335-42 pubmed publisher
    ..Arguments relevant to this set of assertions are advanced and this paper, which was based on the 2011 Adolph Lecture, represents an effort to fill the intellectual void left by reductionism and improve scientific progress. ..
  8. Joyner M. Precision Medicine, Cardiovascular Disease and Hunting Elephants. Prog Cardiovasc Dis. 2016;58:651-60 pubmed publisher
    ..Failure to engage in such debate will lead to negative unintended consequences from a revolution that might never come. ..
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    Joyner M, Dietz N. Nitric oxide and vasodilation in human limbs. J Appl Physiol (1985). 1997;83:1785-96 pubmed
    ..Much work remains for those interested in the role of NO in the regulation of blood flow to the skin and skeletal muscle of humans...

More Information


  1. Baker S, Limberg J, Ranadive S, Joyner M. Neurovascular control of blood pressure is influenced by aging, sex, and sex hormones. Am J Physiol Regul Integr Comp Physiol. 2016;311:R1271-R1275 pubmed publisher
    ..It is likely that the β-adrenergic receptors and/or changes in baroreflex sensitivity play a large role in these sex differences and changes with alterations in sex hormones. ..
  2. Welch B, Petersen Jones H, Eugene A, Brinjikji W, Kallmes D, Curry T, et al. Impact of sleep disordered breathing on carotid body size. Respir Physiol Neurobiol. 2017;236:5-10 pubmed publisher
    ..45-0.59). We conclude carotid body size can be detected by CTA with high inter-observer agreement; however, carotid body size is not increased in patients with sleep apnea. ..
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    Joyner M, Dietz N, Shepherd J. From Belfast to Mayo and beyond: the use and future of plethysmography to study blood flow in human limbs. J Appl Physiol (1985). 2001;91:2431-41 pubmed