Michael Joyner

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. ncbi request reprint Geldanamycin attenuates NO-mediated dilation in human skin
    Shubha Shastry
    Department of Anesthesiology and Physiology, Mayo Clinic and Foundation, 200 First St SW, Rochester, MN 55905, USA
    Am J Physiol Heart Circ Physiol 282:H232-6. 2002
  2. doi request reprint Role of the carotid body chemoreceptors in baroreflex control of blood pressure during hypoglycaemia in humans
    Jacqueline K Limberg
    Department of Anesthesiology, Mayo Clinic, 200 1st Street SW, SMH Joseph 4 184, Rochester, MN 55905, USA
    Exp Physiol 99:640-50. 2014
  3. doi request reprint Blood pressure regulation: every adaptation is an integration?
    Michael J Joyner
    Department of Anesthesiology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA
    Eur J Appl Physiol 114:445-50. 2014
  4. pmc Sex-specific risk of cardiovascular disease and cognitive decline: pregnancy and menopause
    Virginia M Miller
    Departments of Surgery and Physiology and Biomedical Engineering, 200 1st St SW, Rochester, MN 55905, USA
    Biol Sex Differ 4:6. 2013
  5. pmc Ten questions about systems biology
    Michael J Joyner
    Department of Anesthesiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Physiol 589:1017-30. 2011
  6. pmc Feeding the sleeping giant: muscle blood flow during whole body exercise
    Michael J Joyner
    Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Physiol 558:1. 2004
  7. pmc Exercise protects the cardiovascular system: effects beyond traditional risk factors
    Michael J Joyner
    Department of Anesthesiology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    J Physiol 587:5551-8. 2009
  8. doi request reprint The two-hour marathon: who and when?
    M J Joyner
    Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota, USA
    J Appl Physiol (1985) 110:275-7. 2011
  9. ncbi request reprint Skeletal and cardiac muscle blood flow
    Michael J Joyner
    Department of Anesthesiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Exerc Sport Sci Rev 33:1-2. 2005
  10. pmc The catecholamines strike back. What NO does not do
    Michael J Joyner
    Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA
    Circ J 73:1783-92. 2009

Detail Information

Publications103 found, 100 shown here

  1. ncbi request reprint Geldanamycin attenuates NO-mediated dilation in human skin
    Shubha Shastry
    Department of Anesthesiology and Physiology, Mayo Clinic and Foundation, 200 First St SW, Rochester, MN 55905, USA
    Am J Physiol Heart Circ Physiol 282:H232-6. 2002
    ..01). The results show that GA can attenuate NO-mediated dilation in human skin, suggesting a potential role for HSP90 in activation of eNOS in the microcirculation...
  2. doi request reprint Role of the carotid body chemoreceptors in baroreflex control of blood pressure during hypoglycaemia in humans
    Jacqueline K Limberg
    Department of Anesthesiology, Mayo Clinic, 200 1st Street SW, SMH Joseph 4 184, Rochester, MN 55905, USA
    Exp Physiol 99:640-50. 2014
    ....
  3. doi request reprint Blood pressure regulation: every adaptation is an integration?
    Michael J Joyner
    Department of Anesthesiology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA
    Eur J Appl Physiol 114:445-50. 2014
    ....
  4. pmc Sex-specific risk of cardiovascular disease and cognitive decline: pregnancy and menopause
    Virginia M Miller
    Departments of Surgery and Physiology and Biomedical Engineering, 200 1st St SW, Rochester, MN 55905, USA
    Biol Sex Differ 4:6. 2013
    ..Research into specific sex differences for these disease processes with attention to an individual's sex chromosomal complement and hormonal status is important and timely...
  5. pmc Ten questions about systems biology
    Michael J Joyner
    Department of Anesthesiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Physiol 589:1017-30. 2011
    ....
  6. pmc Feeding the sleeping giant: muscle blood flow during whole body exercise
    Michael J Joyner
    Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Physiol 558:1. 2004
  7. pmc Exercise protects the cardiovascular system: effects beyond traditional risk factors
    Michael J Joyner
    Department of Anesthesiology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    J Physiol 587:5551-8. 2009
    ..Our goal is to use selected data from our own work and that of others to stimulate debate on the nature and cause of the 'risk factor gap' associated with exercise and physical activity...
  8. doi request reprint The two-hour marathon: who and when?
    M J Joyner
    Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota, USA
    J Appl Physiol (1985) 110:275-7. 2011
    ..From a physiological perspective, more information is clearly needed on the relationship between VO(2max) and running economy and the influence of running economy and body size on thermoregulation and fuel use...
  9. ncbi request reprint Skeletal and cardiac muscle blood flow
    Michael J Joyner
    Department of Anesthesiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Exerc Sport Sci Rev 33:1-2. 2005
  10. pmc The catecholamines strike back. What NO does not do
    Michael J Joyner
    Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA
    Circ J 73:1783-92. 2009
    ..Thus the role of NO in two of the most extreme dilator responses seen in nature is limited and in muscle the sympathetic nerves can restrain the dilation to defend arterial blood pressure...
  11. pmc Exercise hyperaemia: is anything obligatory but the hyperaemia?
    Michael J Joyner
    Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    J Physiol 583:855-60. 2007
    ....
  12. pmc Found in translation: neural feedback from exercising muscles
    Michael J Joyner
    Department of Anaesthesiology and General Clinical Research Center, Mayo Clinic, Rochester, MN, USA
    J Physiol 567:362-3. 2005
  13. pmc POTS versus deconditioning: the same or different?
    Michael J Joyner
    Dept of Anesthesiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Clin Auton Res 18:300-7. 2008
    ..As always, we must also ask what do the ideas about physical activity and inactivity and the conditions mentioned above not explain?..
  14. pmc A sympathetic view of the sympathetic nervous system and human blood pressure regulation
    Michael J Joyner
    Departments of Anesthesiology and Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Exp Physiol 93:715-24. 2008
    ....
  15. ncbi request reprint Baroreceptor function during exercise: resetting the record
    Michael J Joyner
    Department of Anaesthesiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Exp Physiol 91:27-36. 2006
    ..Additionally, the key contributions of John Shepherd and the late David Donald (along with their colleagues) on related issues are noted...
  16. pmc Endurance exercise performance: the physiology of champions
    Michael J Joyner
    Departments of Anaesthesiology and Physiology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    J Physiol 586:35-44. 2008
    ..Therefore, the performance of elite athletes is likely to defy the types of easy explanations sought by scientific reductionism and remain an important puzzle for those interested in physiological integration well into the future...
  17. doi request reprint What we talk about when we talk with medical students
    Michael J Joyner
    Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Adv Physiol Educ 35:16-21. 2011
    ..In this article, we discuss the philosophy behind the themes outlined above and argue that questions, and not answers, are where the action is for both research and education...
  18. pmc Giant sucking sound: can physiology fill the intellectual void left by the reductionists?
    Michael J Joyner
    Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA
    J Appl Physiol (1985) 111:335-42. 2011
    ..Arguments relevant to this set of assertions are advanced and this paper, which was based on the 2011 Adolph Lecture, represents an effort to fill the intellectual void left by reductionism and improve scientific progress...
  19. ncbi request reprint Counterpoint: the muscle metaboreflex does restore blood flow to contracting muscles
    Michael J Joyner
    Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    J Appl Physiol 100:358-60; discussion 360. 2006
  20. ncbi request reprint Nitric oxide and vasodilation in human limbs
    M J Joyner
    Department of Anesthesiology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Appl Physiol (1985) 83:1785-96. 1997
    ..Much work remains for those interested in the role of NO in the regulation of blood flow to the skin and skeletal muscle of humans...
  21. pmc VO2MAX, blood doping, and erythropoietin
    M J Joyner
    Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA
    Br J Sports Med 37:190-1. 2003
  22. ncbi request reprint Muscle blood flow during exercise: the limits of reductionism
    M J Joyner
    Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA
    Med Sci Sports Exerc 31:1036-40. 1999
    ..We propose that understanding the mechanisms responsible for the "delinking" of flow and metabolism, along with a more synergistic view of current concepts, can provide new insight into the mechanisms which govern exercise hyperemia...
  23. pmc Having it both ways? Vasoconstriction in contracting muscles
    Michael J Joyner
    Department of Anesthesiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Physiol 550:333. 2003
  24. ncbi request reprint From Belfast to Mayo and beyond: the use and future of plethysmography to study blood flow in human limbs
    M J Joyner
    Department of Physiology, Mayo Clinic and Foundation, 200 First St SW, Rochester, MN 55905, USA
    J Appl Physiol (1985) 91:2431-41. 2001
    ....
  25. pmc Ageing reduces nitric-oxide- and prostaglandin-mediated vasodilatation in exercising humans
    William G Schrage
    Department of Kinesiology, 1149A Natatorium, University of Wisconsin, Madison, WI 53706, USA
    J Physiol 579:227-36. 2007
    ..Lower exercise hyperaemia in older humans may be mediated in part by less NO- and PG-mediated vasodilatation during exercise...
  26. ncbi request reprint Vascular response to angiotensin II in upper body obesity
    Søren Nielsen
    Endocrine Research Unit, Mayo Clinic, Rochester, Minn 55905, USA
    Hypertension 44:435-41. 2004
    ..Angiotensin II-stimulated forearm vasoconstriction is increased in viscerally obese normotensive men...
  27. pmc Blunted sympathetic vasoconstriction in contracting skeletal muscle of healthy humans: is nitric oxide obligatory?
    Frank A Dinenno
    Department of Anesthesiology and General Clinical Research Center, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    J Physiol 553:281-92. 2003
    ..Taken together, our results demonstrate that NO is not obligatory for functional sympatholysis in contracting skeletal muscles of healthy men...
  28. ncbi request reprint Exogenous NO administration and alpha-adrenergic vasoconstriction in human limbs
    Jaya B Rosenmeier
    Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA
    J Appl Physiol 95:2370-4. 2003
    ..In conclusion, these results indicate that exogenous NO sufficient to raise blood flow to levels simulating those seen during exercise does not blunt alpha-adrenergic vasoconstriction in the resting human forearm...
  29. ncbi request reprint Combined NO and PG inhibition augments alpha-adrenergic vasoconstriction in contracting human skeletal muscle
    Frank A Dinenno
    Dept of Health and Exercise Science, Colorado State Univ, 220 Moby B Complex, Fort Collins, CO 80523 1582, USA
    Am J Physiol Heart Circ Physiol 287:H2576-84. 2004
    ....
  30. ncbi request reprint The Arg16/Gly beta2-adrenergic receptor polymorphism is associated with altered cardiovascular responses to isometric exercise
    John H Eisenach
    Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Physiol Genomics 16:323-8. 2004
    ....
  31. ncbi request reprint Effects of chronic sympathectomy on vascular function in the human forearm
    John H Eisenach
    Department of Anesthesiology, General Clinical Research Center, Mayo Clinic and Mayo Medical School, Rochester, Minnesota 55905, USA
    J Appl Physiol 92:2019-25. 2002
    ..The normal vasoconstrictor responses to tyramine indicate that there were viable sympathetic nerves in the forearm that were not engaged by LBNP...
  32. pmc Exercise intensity-dependent contribution of beta-adrenergic receptor-mediated vasodilatation in hypoxic humans
    Brad W Wilkins
    Department of Human Physiology, 122 Esslinger Hall, 1240 University of Oregon, Eugene, OR 97403 1240, USA
    J Physiol 586:1195-205. 2008
    ..Thus, in the absence of overlying vasoconstriction, the contribution of beta-adrenergic mechanisms to the augmented hypoxic vasodilatation is dependent on exercise intensity...
  33. pmc Is sympathetic neural vasoconstriction blunted in the vascular bed of exercising human muscle?
    Michael E Tschakovsky
    School of Physical and Health Education, Queen s University, Kingston, ON, Canada K7L 3N6
    J Physiol 541:623-35. 2002
    ..This blunting appears to be exercise intensity-dependent...
  34. pmc Beta(2)-adrenergic receptor polymorphism and nitric oxide-dependent forearm blood flow responses to isoproterenol in humans
    Vesna D Garovic
    Division of Hypertension, Department of Internal Medicine, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA
    J Physiol 546:583-9. 2003
    ..In contrast to previous reports based on systemic infusions of beta(2)-agonists, our findings indicate that regional blood flow responses to locally infused isoproterenol are significantly greater in Gly16 than in Arg16 homozygotes...
  35. pmc Failure of systemic hypoxia to blunt alpha-adrenergic vasoconstriction in the human forearm
    Frank A Dinenno
    Department of Anesthesiology and General Clinical Research Center, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    J Physiol 549:985-94. 2003
    ..Our results demonstrate that post-junctional alpha-adrenergic receptor vasoconstrictor responsiveness to endogenous noradrenaline release is not blunted during mild-to-moderate systemic hypoxia in healthy humans...
  36. ncbi request reprint Nitric oxide and physiologic vasodilation in human limbs: where do we go from here?
    Michael J Joyner
    Dept of Anesthesiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905 USA
    Can J Appl Physiol 28:475-90. 2003
    ..Our findings are placed in context with data from others, and possible future areas of study are identified...
  37. pmc Post-junctional alpha-adrenoceptors and basal limb vascular tone in healthy men
    Frank A Dinenno
    Department of Anesthesiology and General Clinical Research Center, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    J Physiol 540:1103-10. 2002
    ..The potential physiological and pathophysiological implications of these findings are discussed...
  38. ncbi request reprint Central chemoreflex sensitivity and sympathetic neural outflow in elite breath-hold divers
    Zeljko Dujic
    Dept of Physiology, Univ of Split School of Medicine, Soltanska 2, 21000 Split, Croatia
    J Appl Physiol (1985) 104:205-11. 2008
    ..Repeated episodes of hypoxemia may not be sufficient to drive an increase in resting sympathetic activity in the absence of additional comorbidities...
  39. pmc Impaired modulation of sympathetic alpha-adrenergic vasoconstriction in contracting forearm muscle of ageing men
    Frank A Dinenno
    Department of Health and Exercise Science, Colorado State University, 220 Moby B Complex, Fort Collins, CO 80523 1582, USA
    J Physiol 567:311-21. 2005
    ..These findings might help explain the greater skeletal muscle vasoconstrictor tone and reduced blood flow during large muscle dynamic exercise in older adults...
  40. pmc beta2-Adrenoceptor gene variation and systemic vasodilatation during ganglionic blockade
    Christiane Hesse
    Department of Anaesthesiology, Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Physiol 588:2669-78. 2010
    ....
  41. pmc alpha1- and alpha2-adrenergic vasoconstriction is blunted in contracting human muscle
    Jaya B Rosenmeier
    Department of Anesthesiology and General Clinical Research Center, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    J Physiol 547:971-6. 2003
    ..We conclude that vasoconstrictor responses mediated via both post-junctional alpha1- and alpha2-adrenergic receptors are blunted in contracting human skeletal muscles...
  42. ncbi request reprint Reduced forearm alpha1-adrenergic vasoconstriction is associated with enhanced heart rate fluctuations in humans
    Shizue Masuki
    Dept of Anesthesiology, Mayo Clinic and Foundation, 200 First St SW, Rochester, MN 55905, and Department of Health and Exercise Science, Colorado State University, Fort Collins, CO, USA
    J Appl Physiol 100:792-9. 2006
    ..These results suggest that, in healthy young subjects, the enhanced HR response to changes in systolic pressure helps maintain the stability of arterial blood pressure when alpha1-adrenergic responsiveness is reduced...
  43. ncbi request reprint Forearm vascular control during acute hyperglycemia in healthy humans
    Ann S Reed
    Department of Endocrinology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Physiol Endocrinol Metab 286:E472-80. 2004
    ..46). Peak endothelium-independent responses to NTP infusion were also unaffected. We conclude that acute, moderate hyperglycemia does not cause short-term impairment of endothelial function in the healthy human forearm...
  44. ncbi request reprint Influence of beta2-adrenergic receptor genotype on airway function during exercise in healthy adults
    Eric M Snyder
    Gonda 5 369, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Chest 129:762-70. 2006
    ..There are known functional polymorphisms of the beta(2)AR, such as substitution of glycine for arginine at codon 16. We sought to determine if this variation in genotype differentially influences airway function during exercise...
  45. ncbi request reprint Go with the flow: sympathetic control of blood flow during recovery from heart failure
    Michael J Joyner
    J Appl Physiol 101:3-4. 2006
  46. pmc Cardiac baroreflex sensitivity is not correlated to sympathetic baroreflex sensitivity within healthy, young humans
    Andrea P Dutoit
    Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA
    Hypertension 56:1118-23. 2010
    ..However, sex-stratified data indicate that sex-based differential correlations might exist...
  47. pmc Effects of respiratory muscle work on blood flow distribution during exercise in heart failure
    Thomas P Olson
    Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    J Physiol 588:2487-501. 2010
    ..Further, HF patients are unable to vasoconstrict locomotor vascular beds beyond NB when presented with a respiratory load...
  48. ncbi request reprint Arterial baroreflex control of heart rate during exercise in postural tachycardia syndrome
    Shizue Masuki
    Department of Anesthesiology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    J Appl Physiol 103:1136-42. 2007
    ..These results suggest that the tachycardia during exercise in POTS was not due to abnormal baroreflex control of HR...
  49. ncbi request reprint Blood pressure variation in healthy humans: a possible interaction with beta-2 adrenergic receptor genotype and renal epithelial sodium channels
    Eric M Snyder
    Division of Cardiovascular Diseases, Department of Internal Medicine, Gonda 5 369, Mayo Clinic and Foundation, 200 1st Street, SW, Rochester, MN 55905, USA
    Med Hypotheses 65:296-9. 2005
    ....
  50. ncbi request reprint Effects of chronic sympathectomy on locally mediated cutaneous vasodilation in humans
    Nisha Charkoudian
    Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Appl Physiol 92:685-90. 2002
    ..These data indicate that endothelial function in human skin is largely preserved after sympathectomy. The altered pattern of the response suggests that the nitric oxide-dependent portion may be accelerated in sympathectomized limbs...
  51. ncbi request reprint Aging and forearm postjunctional alpha-adrenergic vasoconstriction in healthy men
    Frank A Dinenno
    Department of Anesthesiology and General Clinical Research Center, Mayo Clinic and Foundation, Rochester, Minn 55905, USA
    Circulation 106:1349-54. 2002
    ..We tested the hypothesis that this is due to a reduction in postjunctional alpha-adrenergic responsiveness to endogenous norepinephrine (NE) release and determined whether this was specific to alpha1- or alpha2-adrenergic receptors...
  52. pmc Influence of locomotor muscle metaboreceptor stimulation on the ventilatory response to exercise in heart failure
    Thomas P Olson
    Department of Internal Medicine and Anesthesiology, Mayo Clinic, Rochester, Minn 55905, USA
    Circ Heart Fail 3:212-9. 2010
    ..We examined the influence of metaboreceptor stimulation on ventilation with and without maintaining end-exercise end-tidal CO(2) levels...
  53. ncbi request reprint Exercise hyperemia: waiting for the reductionists?
    Michael J Joyner
    Am J Physiol Heart Circ Physiol 291:H1032-3. 2006
  54. ncbi request reprint Angiotensin-converting enzyme genotype modulates pulmonary function and exercise capacity in treated patients with congestive stable heart failure
    M Roselle Abraham
    Division of Cardiovascular, Mayo Clinic and Foundation, Rochester, Minn 55905, USA
    Circulation 106:1794-9. 2002
    ..The aim of the current study was to determine if ACE genotype is associated with altered pulmonary function and exercise intolerance in patients with treated CHF...
  55. ncbi request reprint Alpha-adrenergic control of skeletal muscle circulation at rest and during exercise in aging humans
    Frank A Dinenno
    Department of Health and Exercise Science, Colorado State University, Fort Collins, Colorado 80522 1582, USA
    Microcirculation 13:329-41. 2006
    ..Further, they discuss how these changes in sympathetic a-adrenergic control of skeletal muscle blood vessels have important physiological and clinical implications for the aging human...
  56. ncbi request reprint Arg16/Gly beta2-adrenergic receptor polymorphism alters the cardiac output response to isometric exercise
    John H Eisenach
    Dept of Anesthesiology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    J Appl Physiol (1985) 99:1776-81. 2005
    ..The influence of polymorphic variants in the beta2-adrenergic receptor gene on the cardiovascular response to sympathoexcitation may have important implications in the development of hypertension and heart failure...
  57. pmc Measuring muscle blood flow: a key link between systemic and regional metabolism
    Darren P Casey
    Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Curr Opin Clin Nutr Metab Care 11:580-6. 2008
    ..To provide a brief overview of the main techniques to measure muscle blood flow in humans and highlight some of the strengths and weaknesses associated with each technique...
  58. ncbi request reprint Beta-2 adrenergic receptor polymorphisms and the forearm blood flow response to mental stress
    Zhong Liu
    Dept of Anesthesiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Clin Auton Res 16:105-12. 2006
    ..Furthermore, the Arg16/Gly beta2-receptor polymorphism has no significant influence on the FBF or cardiovascular responses to mental stress...
  59. ncbi request reprint Agonist-dependent variablity of contributions of nitric oxide and prostaglandins in human skeletal muscle
    William G Schrage
    Dept of Anesthesiology, Joseph 4 184W, Mayo Clinic, Rochester, MN 55905, USA
    J Appl Physiol (1985) 98:1251-7. 2005
    ..The NOS + COX-independent dilation does not appear sensitive to feedback inhibition from NO in the human forearm...
  60. doi request reprint Human phenylethanolamine N-methyltransferase genetic polymorphisms and exercise-induced epinephrine release
    Yuan Ji
    Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Mayo Foundation, Rochester, Minnesota 55905, USA
    Physiol Genomics 33:323-32. 2008
    ..Our studies suggest that functionally significant variant sequence in the human PNMT gene might contribute to individual variation in levels of circulating epinephrine during exercise...
  61. pmc Cardiovascular dynamics in healthy subjects with differing heart rate responses to tilt
    Farah A Ramirez-Marrero
    Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Appl Physiol (1985) 105:1448-53. 2008
    ..Although interindividual variability appears to be a fundamental part of cardiovascular regulation, the mechanisms of these differences and the sex discrepancy requires further investigation...
  62. pmc Sex differences in sympathetic neural-hemodynamic balance: implications for human blood pressure regulation
    Emma C Hart
    Department of Anesthesiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Hypertension 53:571-6. 2009
    ..These findings may have important implications for understanding how hypertension and other disorders of blood pressure regulation occur in men and women...
  63. pmc Age-related differences in the sympathetic-hemodynamic balance in men
    Emma C Hart
    Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA
    Hypertension 54:127-33. 2009
    ....
  64. pmc Skeletal muscle blood flow responses to hypoperfusion at rest and during rhythmic exercise in humans
    Darren P Casey
    Department of Anesthesiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    J Appl Physiol (1985) 107:429-37. 2009
    ....
  65. pmc Blood pressure regulation in humans: calculation of an "error signal" in control of sympathetic nerve activity
    Erica A Wehrwein
    Departments of Anesthesiology, Mayo Clinic, Rochester, Minn 55904, USA
    Hypertension 55:264-9. 2010
    ..The relationship between error signal and burst incidence may provide important insight into the control of muscle sympathetic nerve activity across sexes and in various populations...
  66. ncbi request reprint Selective alpha2-adrenergic properties of dexmedetomidine over clonidine in the human forearm
    Shizue Masuki
    Department of Anesthesiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Appl Physiol 99:587-92. 2005
    ..The similar vasoconstrictor responses to both drugs after prazosin might be explained by the presynaptic effects on norepinephrine release...
  67. pmc Gastric bypass surgery is associated with near-normal insulin suppression of lipolysis in nondiabetic individuals
    Timothy B Curry
    Depts of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA
    Am J Physiol Endocrinol Metab 300:E746-51. 2011
    ..However, some differences in insulin sensitivity in GB remain compared with L. Residual insulin resistance may be related to excess total body fat or abnormal lipolysis and requires further study...
  68. pmc Nitric oxide-mediated vasodilation becomes independent of beta-adrenergic receptor activation with increased intensity of hypoxic exercise
    Darren P Casey
    Dept of Anesthesiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    J Appl Physiol (1985) 110:687-94. 2011
    ..However, the source of the NO becomes less dependent on β-adrenergic mechanisms as exercise intensity increases...
  69. pmc Arg16Gly polymorphism of the beta2-adrenergic receptor is associated with differences in cardiovascular function at rest and during exercise in humans
    Eric M Snyder
    Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic and Foundation, 200 1st Street, SW, Rochester, MN 55905, USA
    J Physiol 571:121-30. 2006
    ..This may suggest possible genotype-related differences in baseline receptor function or density which causes phenotypic differences at rest that are sustained during short-term exercise...
  70. pmc The Arg16Gly polymorphism of the beta2-adrenergic receptor and the natriuretic response to rapid saline infusion in humans
    Eric M Snyder
    Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Physiol 574:947-54. 2006
    ..28 +/- 0.03; P < 0.01). These results suggest that the Arg16Gly polymorphism of the beta2AR is associated with differences in natriuretic response to rapid saline infusion, which may influence long-term regulation of blood pressure...
  71. pmc Systemic hypoxia and vasoconstrictor responsiveness in exercising human muscle
    Brad W Wilkins
    Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA
    J Appl Physiol (1985) 101:1343-50. 2006
    ..22 +/- 4%), and at 20% exercise (-22 +/- 5 vs. -14 +/- 4%) between hypoxia and normoxia, respectively. Thus sympatholysis is not augmented by moderate hypoxia nor does it contribute to the increased blood flow during hypoxic exercise...
  72. ncbi request reprint Influences of adenosine receptor antagonism on vasodilator responses to adenosine and exercise in adenosine responders and nonresponders
    Elizabeth A Martin
    Department of Anesthesiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    J Appl Physiol (1985) 101:1678-84. 2006
    ..05 before vs. after Aph). We conclude that there may be reduced Ado receptor responsiveness or sensitivity in nonresponders. Furthermore, Ado may play a limited role exercise hyperemia in both subgroups...
  73. pmc Adenosine transporter antagonism in humans augments vasodilator responsiveness to adenosine, but not exercise, in both adenosine responders and non-responders
    Elizabeth A Martin
    Department of Anesthesiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Physiol 579:237-45. 2007
    ..The failure of DIP to augment exercise hyperemia under these conditions suggests that ADO concentrations may not rise enough during rhythmic handgripping to have a major impact on these responses...
  74. ncbi request reprint Genetic variation of the beta2-adrenergic receptor is associated with differences in lung fluid accumulation in humans
    Eric M Snyder
    Department of Internal Medicine, Mayo Clinic College of Medicine, 200 1st St, SW, Rochester, MN 55905, USA
    J Appl Physiol (1985) 102:2172-8. 2007
    ..Gly16, respectively, means+/-SD). These data suggest that subjects homozygous for Arg at amino acid 16 of the beta2AR have a greater susceptibility for lung fluid accumulation relative to subjects homozygous for Gly at this position...
  75. ncbi request reprint Preserved reflex cutaneous vasodilation in cystic fibrosis does not include an enhanced nitric oxide-dependent mechanism
    Brad W Wilkins
    Department of Anesthesiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    J Appl Physiol (1985) 102:2301-6. 2007
    ..8) to a similar degree. Thus the preservation of cutaneous active vasodilation in subjects with CF is not associated with an enhanced NO-dependent vasodilation...
  76. pmc Hyperbaric hyperoxia reduces exercising forearm blood flow in humans
    Darren P Casey
    Dept of Anesthesiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905
    Am J Physiol Heart Circ Physiol 300:H1892-7. 2011
    ..01). Our data suggest that exercise hyperemia in skeletal muscle is highly dependent on oxygen availability during hyperoxia...
  77. pmc Influences of hydration on post-exercise cardiovascular control in humans
    Nisha Charkoudian
    Department of Anaesthesiology, Mayo Clinic and Foundation, Rochester, MN, USA
    J Physiol 552:635-44. 2003
    ..We conclude that exercise-induced dehydration causes post-exercise changes in the baroreflex control of blood pressure that may contribute to, rather than offset, orthostatic intolerance...
  78. pmc Contribution of adenosine to compensatory dilation in hypoperfused contracting human muscles is independent of nitric oxide
    Darren P Casey
    Department of Anesthesiology, Mayo Clinic Rochester, MN 55905, USA
    J Appl Physiol (1985) 110:1181-9. 2011
    ..05 vs. aminophylline). Our data indicate that adenosine contributes to compensatory vasodilation in an NO-independent manner during exercise with acute hypoperfusion...
  79. pmc Dietary sodium restriction and beta2-adrenergic receptor polymorphism modulate cardiovascular function in humans
    John H Eisenach
    Department of Anaesthesiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Physiol 574:955-65. 2006
    ..This study provides evidence that dietary Na+ modulates effects of the Arg16Gly polymorphism on cardiovascular function...
  80. pmc Ageing reduces the compensatory vasodilatation during hypoxic exercise: the role of nitric oxide
    Darren P Casey
    Department of Anesthesiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    J Physiol 589:1477-88. 2011
    ..L-NMMA during hypoxic exercise only blunted the compensatory vasodilator response in the young group (P <0.05). Our data suggest that ageing reduces the compensatory vasodilator response to hypoxic exercise via blunted NO signalling...
  81. pmc Relationship between muscle sympathetic nerve activity and aortic wave reflection characteristics in young men and women
    Darren P Casey
    Department of Anesthesiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Hypertension 57:421-7. 2011
    ..59), and wasted left ventricular energy (r = -0.58; P<0.01 for all). Our results suggest another possible mechanism by which young women are protected against the development of cardiovascular disease...
  82. pmc Nitric oxide contributes to the augmented vasodilatation during hypoxic exercise
    Darren P Casey
    Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA
    J Physiol 588:373-85. 2010
    ..7 vs. -21.4 +/- 5.2%; P = 0.28) and 20% (-13.4 +/- 3.5 vs. -18.8 +/- 4.5%; P = 0.18) hypoxic exercise. These findings suggest that NO contributes to the augmented vasodilatation observed during hypoxic exercise independent of adenosine...
  83. pmc Aging decreases expression and activity of glutathione peroxidase-1 in human endothelial progenitor cells
    Tongrong He
    Department of Anesthesiology and Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Microvasc Res 78:447-52. 2009
    ..The results indicate that GPX1 may represent a potential therapeutic target for enhancement of regenerative capacity of EPCs in old subjects...
  84. pmc Energy expenditure and activity of transfemoral amputees using mechanical and microprocessor-controlled prosthetic knees
    Kenton R Kaufman
    Motion Analysis Laboratory, Mayo Clinic, Rochester, MN 55905, USA
    Arch Phys Med Rehabil 89:1380-5. 2008
    ..To quantify the energy efficiency of locomotion and free-living physical activity energy expenditure of transfemoral amputees using a mechanical and microprocessor-controlled prosthetic knee...
  85. ncbi request reprint Changes in red blood cell transfusion practice during the past two decades: a retrospective analysis, with the Mayo database, of adult patients undergoing major spine surgery
    C Thomas Wass
    Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Transfusion 47:1022-7. 2007
    ..Similar data for patients undergoing major spine surgery, however, are not available...
  86. pmc Exercise hyperemia and vasoconstrictor responses in humans with cystic fibrosis
    William G Schrage
    Department of Anesthesiology and General Clinical Research Center, Mayo Clinic, Rochester, MN 55905, USA
    J Appl Physiol (1985) 99:1866-71. 2005
    ..22). Our results suggest that ATP released from the deformation of erythrocytes is not an obligatory signal for exercise hyperemia in human skeletal muscle...
  87. ncbi request reprint Reduced stroke volume during exercise in postural tachycardia syndrome
    Shizue Masuki
    Department of Anesthesiology, Mayo Clinic Foundation, Rochester, MN 55905, USA
    J Appl Physiol 103:1128-35. 2007
    ..60), and 75 W (R(2) = 0.32) (P < 0.01). These results suggest that greater elevation in HR in POTS patients during exercise, especially while upright, was secondary to reduced SV and associated with exercise intolerance...
  88. ncbi request reprint Genotype related differences in beta2 adrenergic receptor density and cardiac function
    Eric M Snyder
    Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Med Sci Sports Exerc 38:882-6. 2006
    ..We sought to determine whether genetic variation of the ADRB2 influenced ADRB2 density and, consequently, resting cardiovascular function...
  89. pmc Adenosine receptor antagonist and augmented vasodilation during hypoxic exercise
    Darren P Casey
    Department of Anesthesiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    J Appl Physiol (1985) 107:1128-37. 2009
    ..05 for both). These observations suggest that adenosine receptor activation is not obligatory for the augmented hyperemia during hypoxic exercise in humans...
  90. ncbi request reprint Effects of pioglitazone versus glipizide on body fat distribution, body water content, and hemodynamics in type 2 diabetes
    Ananda Basu
    Division of Endocrinology and Metabolism, 200 First Street SW, Rochester, MN 55905, USA
    Diabetes Care 29:510-4. 2006
    ..Our study was designed to examine the effects of pioglitazone versus glipizide on body water, body composition, and hemodynamic parameters in the presence of comparable glycemic control between groups...
  91. ncbi request reprint Physiologic considerations for exercise performance in women
    Nisha Charkoudian
    Department of Physiology, Mayo Clinic Rochester, 200 First Street Southwest, Rochester, MN 55905, USA
    Clin Chest Med 25:247-55. 2004
    ..It is important for women to include regular exercise in their daily routines, particularly because regular physical activity has been implicated in the prevention of osteoporosis, breast cancer, heart disease, and depression...
  92. ncbi request reprint Bimodal distribution of vasodilator responsiveness to adenosine due to difference in nitric oxide contribution: implications for exercise hyperemia
    Elizabeth A Martin
    Dept of Anesthesiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    J Appl Physiol (1985) 101:492-9. 2006
    ..Finally, our data support the concept that neither Ado nor nitric oxide is obligatory for exercise hyperemia...
  93. ncbi request reprint Beneficial effects of GLP-1 on endothelial function in humans: dampening by glyburide but not by glimepiride
    Ananda Basu
    Division of Endocrinology and Metabolism, 5 193 Joseph, Saint Mary s Hospital, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Am J Physiol Endocrinol Metab 293:E1289-95. 2007
    ..04). Neither GLP-1 nor SU altered NTP-induced vasodilatation. These data demonstrate that GLP-1 per se has direct beneficial effects on endothelium-dependent vasodilatation in humans that are differentially modulated by SU...
  94. ncbi request reprint Effects of combined inhibition of ATP-sensitive potassium channels, nitric oxide, and prostaglandins on hyperemia during moderate exercise
    William G Schrage
    Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA
    J Appl Physiol (1985) 100:1506-12. 2006
    ..However, some subjects are sensitive to triple blockade, but they are able to restore FBF acutely during exercise. Future studies are required to determine the nature of these compensatory mechanisms in the affected individuals...
  95. pmc Local inhibition of nitric oxide and prostaglandins independently reduces forearm exercise hyperaemia in humans
    William G Schrage
    Department Anaesthesiology, Mayo Clinic, Rochester, MN 55905, USA
    J Physiol 557:599-611. 2004
    ..PGs contribute modestly and transiently, suggesting a redundant signal compensates for the loss of vasodilating PGs, and (3). NO and PG signals appear to contribute independently to forearm exercise hyperaemia...
  96. pmc Nicotine increases initial blood flow responses to local heating of human non-glabrous skin
    David O Warner
    Department of Anaesthesiology, Mayo Clinic College of Medicine, Rochester, MN, USA
    J Physiol 559:975-84. 2004
    ..In contrast, nicotine decreases SkBF responses to prolonged heating by activating noradrenergic nerves...
  97. ncbi request reprint Effects of midodrine on exercise-induced hypotension and blood pressure recovery in autonomic failure
    William G Schrage
    Department of Anesthesia Research, Joseph 4 184W, Mayo Clinic, Rochester, MN 55905, USA
    J Appl Physiol (1985) 97:1978-84. 2004
    ..02). We conclude midodrine improves blood pressure and TPR during exercise and dramatically improves the recovery of MAP after exercise...
  98. pmc NOS inhibition blunts and delays the compensatory dilation in hypoperfused contracting human muscles
    Darren P Casey
    Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Appl Physiol (1985) 107:1685-92. 2009
    ..These observations suggest that NO is released by contracting muscles or that a portion of the dilation caused by ischemic metabolites is NO dependent...
  99. pmc Baroreflex control of muscle sympathetic nerve activity: a nonpharmacological measure of baroreflex sensitivity
    Emma C Hart
    Dept of Anesthesiology, Mayo Clinic, Rochester, MN 59906, USA
    Am J Physiol Heart Circ Physiol 298:H816-22. 2010
    ..Furthermore, the modified Oxford method does not appear to alter the properties of the baroreflex...
  100. pmc Aging is associated with reduced prostacyclin-mediated dilation in the human forearm
    Wayne T Nicholson
    Department of Anesthesiology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Hypertension 53:973-8. 2009
    ..Our data suggest that the reduced dilator effects of PGI(2) in older individuals are attributable to a reduction in the contribution of endothelial-derived NO versus alterations in the direct effects of PGI(2) on vascular smooth muscle...
  101. ncbi request reprint Comment on Point:Counterpoint "Flow-mediated dilation does/does not reflect nitric oxide-mediated endothelial function"
    Michael J Joyner
    J Appl Physiol 99:2452. 2005

Research Grants25

  1. Perfusion of Active Muscles: Metabolites and Nerves
    Michael Joyner; Fiscal Year: 2009
    ..We propose novel and innovative strategies to address a number of currently unresolved issues and controversies related to these topics in humans. ..
  2. Perfusion of Active Muscles: Metabolites and Nerves
    Michael J Joyner; Fiscal Year: 2010
    ..We propose novel and innovative strategies to address a number of currently unresolved issues and controversies related to these topics in humans. ..
  3. Perfusion of Active Muscles: Metabolites and Nerves
    Michael Joyner; Fiscal Year: 2009
    ..We propose novel and innovative strategies to address a number of currently unresolved issues and controversies related to these topics in humans. ..
  4. Neurovascular Control and Blood Pressure Regulation in Humans
    Michael J Joyner; Fiscal Year: 2010
    ..In summary, this overall approach will permit us to understand how normotensive is maintained in humans with high baseline sympathetic activity and set the stage for understanding how these mechanisms might fail in hypertension. ..
  5. Perfusion of Active Muscles: Metabolites and Nerves
    Michael Joyner; Fiscal Year: 2005
    ..abstract_text> ..
  6. NO AND EXERCISE VASODILATION IN HUMAN HYPERLIPIDEMIA
    Michael Joyner; Fiscal Year: 2004
    ..Data from these patient- oriented studies have implications related to understanding the contribution of endothelial function in a variety of common diseases. ..
  7. PERFUSION OF ACTIVE MUSCLES--METABOLITES AND NERVES
    Michael Joyner; Fiscal Year: 2001
    ..These vasodilating mechanisms may have significance in a variety of disease states associated with endothelial and autonomic dysfunction. ..
  8. Neurovascular Control and Blood Pressure Regulation in Humans
    Michael J Joyner; Fiscal Year: 2010
    ..In summary, this overall approach will permit us to understand how normotensive is maintained in humans with high baseline sympathetic activity and set the stage for understanding how these mechanisms might fail in hypertension. ..