Richard W Joseph
Affiliation: Mayo Clinic
- Correlation of NRAS mutations with clinical response to high-dose IL-2 in patients with advanced melanomaRichard W Joseph
Department of Melanoma Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, TX, USA
J Immunother 35:66-72. 2012..56 vs. 1.97 y, P<0.0001), and trended toward a decreased response rate (7% vs. 21%, P=0.08). NRAS mutational status is a new candidate biomarkers for selecting patients with melanoma for HD IL-2 treatment...
- Therapy for metastatic melanoma: the past, present, and futureLaura Finn
Division of Hematology and Oncology, Mayo Clinic Florida, 4500 San Pablo Road, Jacksonville, FL 32224, USA
BMC Med 10:23. 2012..In this review we will discuss the advantages and limitations of the two new approved agents, current clinical trials designed to overcome these limitations, and future clinical trials that we feel hold the most promise...
- NRAS mutation status is an independent prognostic factor in metastatic melanomaJohn A Jakob
Department of Melanoma Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
Cancer 118:4014-23. 2012....
- A randomized phase II study of cilengitide (EMD 121974) in patients with metastatic melanomaKevin B Kim
Department of Melanoma Medical Oncology, MD Anderson Cancer Center, The University of Texas, Houston, Texas 77030, USA
Melanoma Res 22:294-301. 2012..05). Cilengitide was well tolerated by patients in both the treatment arms but had minimal clinical efficacy as a single-agent therapy for metastatic melanoma, and the efficacy was not related to baseline αvβ3 expression...
- Characterizing the clinical benefit of ipilimumab in patients who progressed on high-dose IL-2Richard W Joseph
Division of Hematology and Oncology, Mayo Clinic, Jacksonville, FL 32224, USA
J Immunother 35:711-5. 2012..Prospective trials of HD IL-2 followed by ipilimumab could potentially identify patients most likely to benefit from a sequential approach of HD IL-2 followed by ipilimumab...
- Impact of clinical and pathologic features on tumor-infiltrating lymphocyte expansion from surgically excised melanoma metastases for adoptive T-cell therapyRichard W Joseph
Department of Melanoma Medical Oncology, The University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 17:4882-91. 2011..However, little is known how clinical and pathologic features impact TIL outgrowth isolated from metastatic melanoma tumors...