Aaron J Johnson
Affiliation: Mayo Clinic
Johnson H, Hanson L, Chen Y, Bieber A, Buono R, Ferraro T, et al
. Quantitative trait loci analysis reveals candidate genes implicated in regulating functional deficit and CNS vascular permeability in CD8 T cell-initiated blood-brain barrier disruption. BMC Genomics. 2013;14:678 pubmed publisher
..These genes encode for factors that may be potential targets for therapeutic approaches to treat disorders characterized by CD8 T cell-mediated BBB disruption. ..
Renner D, Malo C, Jin F, Parney I, Pavelko K, Johnson A. Improved Treatment Efficacy of Antiangiogenic Therapy when Combined with Picornavirus Vaccination in the GL261 Glioma Model. Neurotherapeutics. 2016;13:226-36 pubmed publisher
Willenbring R, Jin F, Hinton D, Hansen M, Choi D, Pavelko K, et al
. Modulatory effects of perforin gene dosage on pathogen-associated blood-brain barrier (BBB) disruption. J Neuroinflammation. 2016;13:222 pubmed publisher
..This study also provides insight into the effect SNVs in a single perforin allele could have on functional deficit in neurological disease. ..
Malo C, Huggins M, Goddery E, Tolcher H, Renner D, Jin F, et al
. Non-equivalent antigen presenting capabilities of dendritic cells and macrophages in generating brain-infiltrating CD8 + T cell responses. Nat Commun. 2018;9:633 pubmed publisher
..These findings reveal distinct functions for dendritic cells and macrophages in generating CD8+ T cell responses to neurological disease. ..
Cumba Garcia L, Huseby Kelcher A, Malo C, Johnson A. Superior isolation of antigen-specific brain infiltrating T cells using manual homogenization technique. J Immunol Methods. 2016;439:23-28 pubmed publisher
..A greater percentage of viable cells was also achieved through dounce homogenization. Therefore, we conclude that manual homogenization is a superior approach to isolate activated T cells from the mouse brain. ..
Huseby Kelcher A, Atanga P, Gamez J, Cumba Garcia L, Teclaw S, Pavelko K, et al
. Brain atrophy in picornavirus-infected FVB mice is dependent on the H-2Db class I molecule. FASEB J. 2017;31:2267-2275 pubmed publisher
..Huseby Kelcher, A. M., Atanga, P. A., Gamez, J. D., Cumba Garcia, L. M., Teclaw, S. J., Pavelko, K. D., Macura, S. I., Johnson. A. J. Brain atrophy in picornavirus-infected FVB mice is dependent on the H-2Db class I molecule. ..
Huggins M, Johnson H, Jin F, N Songo A, Hanson L, Lafrance S, et al
. Perforin Expression by CD8 T Cells Is Sufficient To Cause Fatal Brain Edema during Experimental Cerebral Malaria. Infect Immun. 2017;85: pubmed publisher
..In turn, leakage from the vasculature into the parenchyma causes brain swelling and edema. This results in a breakdown of homeostatic maintenance that likely contributes to ECM pathology. ..
Willenbring R, Johnson A. Finding a Balance between Protection and Pathology: The Dual Role of Perforin in Human Disease. Int J Mol Sci. 2017;18: pubmed publisher
..It concludes with a novel hypothesis that diversity observed in the PRF1 gene may be an example of selective advantage that protects an individual from perforin-mediated pathology, such as BBB disruption. ..