Aaron J Johnson

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Quantitative trait loci analysis reveals candidate genes implicated in regulating functional deficit and CNS vascular permeability in CD8 T cell-initiated blood-brain barrier disruption
    Holly L Johnson
    Department of Neurology, Mayo Clinic, Rochester, MN, USA
    BMC Genomics 14:678. 2013
  2. pmc Preserved vascular integrity and enhanced survival following neuropilin-1 inhibition in a mouse model of CD8 T cell-initiated CNS vascular permeability
    Georgette L Suidan
    Neuroscience Graduate Program, University of Cincinnati, Cincinnati, OH 45267, USA
    J Neuroinflammation 9:218. 2012
  3. pmc A hematopoietic contribution to microhemorrhage formation during antiviral CD8 T cell-initiated blood-brain barrier disruption
    Holly L Johnson
    Department of Neurology, Mayo Clinic, Rochester, MN, USA
    J Neuroinflammation 9:60. 2012
  4. pmc CD8 T cell-initiated blood-brain barrier disruption is independent of neutrophil support
    Holly L Johnson
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 189:1937-45. 2012
  5. pmc CD8 T cell-initiated vascular endothelial growth factor expression promotes central nervous system vascular permeability under neuroinflammatory conditions
    Georgette L Suidan
    Neuroscience Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 184:1031-40. 2010
  6. pmc CMV infection attenuates the disease course in a murine model of multiple sclerosis
    Istvan Pirko
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 7:e32767. 2012
  7. pmc Deep gray matter T2 hypointensity correlates with disability in a murine model of MS
    Istvan Pirko
    Department of Neurology, University of Cincinnati, Cincinnati, OH 45267, USA
    J Neurol Sci 282:34-8. 2009
  8. pmc Contrasting roles for CD4 vs. CD8 T-cells in a murine model of virally induced "T1 black hole" formation
    Istvan Pirko
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 7:e31459. 2012
  9. pmc Rapid formation of extended processes and engagement of Theiler's virus-infected neurons by CNS-infiltrating CD8 T cells
    Jeremiah R McDole
    Departments of Neurology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Am J Pathol 177:1823-33. 2010
  10. pmc Acute hemorrhagic demyelination in a murine model of multiple sclerosis
    Istvan Pirko
    Department of Neurology and Neuroscience, University of Cincinnati, Cincinnati, Ohio, USA
    J Neuroinflammation 5:31. 2008

Collaborators

Detail Information

Publications22

  1. pmc Quantitative trait loci analysis reveals candidate genes implicated in regulating functional deficit and CNS vascular permeability in CD8 T cell-initiated blood-brain barrier disruption
    Holly L Johnson
    Department of Neurology, Mayo Clinic, Rochester, MN, USA
    BMC Genomics 14:678. 2013
    ....
  2. pmc Preserved vascular integrity and enhanced survival following neuropilin-1 inhibition in a mouse model of CD8 T cell-initiated CNS vascular permeability
    Georgette L Suidan
    Neuroscience Graduate Program, University of Cincinnati, Cincinnati, OH 45267, USA
    J Neuroinflammation 9:218. 2012
    ..Our laboratory has developed a murine model of CD8 T cell-initiated central nervous system (CNS) vascular permeability in which vascular endothelial growth factor (VEGF) signaling plays a prominent role in BBB disruption...
  3. pmc A hematopoietic contribution to microhemorrhage formation during antiviral CD8 T cell-initiated blood-brain barrier disruption
    Holly L Johnson
    Department of Neurology, Mayo Clinic, Rochester, MN, USA
    J Neuroinflammation 9:60. 2012
    ..Therefore, we hypothesize that hematopoietic factors contribute to susceptibility to brain hemorrhage, CNS vascular permeability and death following induction of PIFS...
  4. pmc CD8 T cell-initiated blood-brain barrier disruption is independent of neutrophil support
    Holly L Johnson
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 189:1937-45. 2012
    ..Our data also provide evidence that CD8 T cells initiate disruption of BBB tight junction proteins and CNS vascular permeability in the absence of neutrophil support...
  5. pmc CD8 T cell-initiated vascular endothelial growth factor expression promotes central nervous system vascular permeability under neuroinflammatory conditions
    Georgette L Suidan
    Neuroscience Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 184:1031-40. 2010
    ....
  6. pmc CMV infection attenuates the disease course in a murine model of multiple sclerosis
    Istvan Pirko
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 7:e32767. 2012
    ..Future studies in this co-infection model will provide insight into mechanisms which modulate the development of demyelination and may be utilized for the development of novel therapeutic strategies...
  7. pmc Deep gray matter T2 hypointensity correlates with disability in a murine model of MS
    Istvan Pirko
    Department of Neurology, University of Cincinnati, Cincinnati, OH 45267, USA
    J Neurol Sci 282:34-8. 2009
    ..We propose that this model will allow mechanistic studies investigating the pathogenesis and significance of deep gray matter T2 hypointensity in MS...
  8. pmc Contrasting roles for CD4 vs. CD8 T-cells in a murine model of virally induced "T1 black hole" formation
    Istvan Pirko
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 7:e31459. 2012
    ..These findings demonstrate contrasting roles for these cell types, with additional evidence for a direct pathogenic role of CD8 T-cells in our model of T1 black hole formation...
  9. pmc Rapid formation of extended processes and engagement of Theiler's virus-infected neurons by CNS-infiltrating CD8 T cells
    Jeremiah R McDole
    Departments of Neurology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Am J Pathol 177:1823-33. 2010
    ....
  10. pmc Acute hemorrhagic demyelination in a murine model of multiple sclerosis
    Istvan Pirko
    Department of Neurology and Neuroscience, University of Cincinnati, Cincinnati, Ohio, USA
    J Neuroinflammation 5:31. 2008
    ..This study is also the first demonstration of rapid demyelination in a TMEV resistant non-demyelinating strain without transgenic alterations or pharmacologically induced immunosuppression...
  11. ncbi request reprint Antigen-specific CD8+ T cells mediate a peptide-induced fatal syndrome
    Aaron J Johnson
    Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Immunol 174:6854-62. 2005
    ..Susceptibility to the syndrome is genetically determined, is mediated by CD8(+) T cells, and requires expression of perforin. These findings raise concerns about the use of peptides and MHC tetramers in therapeutic schemes...
  12. doi request reprint Multiple sclerosis: pathogenesis and MR imaging features of T1 hypointensities in a [corrected] murine model
    Istvan Pirko
    Department of Neurology, University of Cincinnati, 260 Stetson St Suite 2300, PO Box 670525, Cincinnati, OH 45267 0525, USA
    Radiology 246:790-5. 2008
    ....
  13. pmc The relevance of animal models in multiple sclerosis research
    Aleksandar Denic
    Molecular Neuroscience Program, Mayo Clinic, Rochester, MN, USA
    Pathophysiology 18:21-9. 2011
    ..Despite their limitations, the rational utilization and application of these models to address specific research questions will remain one of the most useful tools in studies of human demyelinating diseases...
  14. pmc Unconjugated bilirubin contributes to early inflammation and edema after intracerebral hemorrhage
    Matthew C Loftspring
    Department of Neurology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Cereb Blood Flow Metab 31:1133-42. 2011
    ..Finally, we found that UBR was associated with an increased expression of the leukocyte adhesion molecule intercellular adhesion molecule-1. Our results suggest that UBR possesses complex immune-modulatory and antioxidant effects...
  15. pmc Nonequivalence of classical MHC class I loci in ability to direct effective antiviral immunity
    Kevin D Pavelko
    Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA
    PLoS Pathog 8:e1002541. 2012
    ..This finding provides a basis for understanding locus-specific differences in MHC polymorphism, characterized best in human populations...
  16. pmc Magnetic resonance imaging, microscopy, and spectroscopy of the central nervous system in experimental animals
    Istvan Pirko
    University of Cincinnati, Department of Neurology, Cincinnati, Ohio 45267, USA
    NeuroRx 2:250-64. 2005
    ..Finally, typical findings in the most common neurological disease categories and novel MRI/magnetic resonance spectroscopy methods used in their study are also described...
  17. ncbi request reprint Theiler's murine encephalomyelitis virus as an experimental model system to study the mechanism of blood-brain barrier disruption
    Holly L Johnson
    Department of Neurology, Mayo Clinic, Rochester, MN, USA
    J Neurovirol 20:107-12. 2014
    ....
  18. ncbi request reprint The CD8 T cell in multiple sclerosis: suppressor cell or mediator of neuropathology?
    Aaron J Johnson
    Department of Neurology, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Int Rev Neurobiol 79:73-97. 2007
    ..We also highlight important new avenues for future research...
  19. ncbi request reprint An elite controller of picornavirus infection targets an epitope that is resistant to immune escape
    Michael P Bell
    Department of Immunology, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 9:e94332. 2014
    ..Furthermore, the immutable nature of the viral antigen highlights the importance of choosing appropriate vaccine antigens and has implications for the development of agents that are able to generate protective CD8 T-cell responses. ..
  20. ncbi request reprint Positivity of cytomegalovirus antibodies predicts a better clinical and radiological outcome in multiple sclerosis patients
    Robert Zivadinov
    Buffalo Neuroimaging Analysis Center, Department of Neurology, The Jacobs Neurological Institute, University at Buffalo, State University of New York, 14203, USA
    Neurol Res 28:262-9. 2006
    ....
  21. pmc Intracerebral hemorrhage leads to infiltration of several leukocyte populations with concomitant pathophysiological changes
    Matthew C Loftspring
    Department of Neurology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0536, USA
    J Cereb Blood Flow Metab 29:137-43. 2009
    ..Thus, we have shown the first use of flow cytometry to analyze leukocyte infiltration in response to ICH. Our finding of a CD4 T-cell infiltrate is novel and suggests a role for the adaptive immune system in the response to ICH...
  22. ncbi request reprint A human antibody that promotes remyelination enters the CNS and decreases lesion load as detected by T2-weighted spinal cord MRI in a virus-induced murine model of MS
    Istvan Pirko
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
    FASEB J 18:1577-9. 2004
    ..The reduction in high signal T2-weighted lesion volume may be an important outcome measure in future clinical trials in humans...